1,104,462 results match your criteria Bacterial Overgrowth Syndrome


Insular Resting State Functional Connectivity is Associated with Gut Microbiota Diversity.

Eur J Neurosci 2018 Dec 16. Epub 2018 Dec 16.

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, 77030, USA.

The gut microbiota has recently gained attention as a possible modulator of brain activity. A number of reports suggest that the microbiota may be associated with neuropsychiatric conditions such as major depressive disorder, autism, and anxiety. The gut microbiota is thought to influence the brain via vagus nerve signaling, among other possible mechanisms. Read More

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December 2018
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Quorum sensing between Gram-negative bacteria responsible for methane production in a complex waste sewage sludge consortium.

Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.

Department of Biological Functions Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu, 808-0196, Japan.

Quorum sensing (QS) plays a key role in activating bacterial functions through small molecules called autoinducers. In this study, the QS of Gram-negative bacteria in waste sewage sludge (WSS) was downregulated by adding the quorum quenching enzyme, AiiM lactonase, which cleaved the acyl-homoserine lactone (AHL) autoinducer signals from Gram-negative bacteria, and subsequently methane production was inhibited by over 400%. The pH was lowered after 2 days in the anaerobic fermentation whereas protease activity at the hydrolysis step was almost the same with or without AiiM. Read More

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December 2018

Induction of apoptosis-like death by periplanetasin-2 in Escherichia coli and contribution of SOS genes.

Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.

School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Korea.

Periplanetasin-2 is a 15-mer antimicrobial peptide (AMP), derived from the American cockroach Periplaneta americana. This novel AMP exhibits potent antibacterial effect against several pathogenic bacteria including Escherichia coli. Distinct from the targeting cell membrane, which is the general antibacterial mechanism of AMP, periplanetasin-2 exerts its antibacterial activity via apoptosis-like death, which is physiologically and mechanistically similar to eukaryotic apoptosis. Read More

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December 2018

Oceanobacillus timonensis sp. nov. and Oceanobacillus senegalensis sp. nov., two new moderately halophilic, Gram-stain positive bacteria isolated from stools sample of healthy young Senegalese.

Antonie Van Leeuwenhoek 2018 Dec 15. Epub 2018 Dec 15.

Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.

Oceanobacillus timonensis Marseille-P3532 (CSUR P3532, CCUG 70981) and Oceanobacillus senegalensis Marseille-P3587 (CSUR P3587, CCUG 70613), are the type strains of O. timonensis sp. nov. Read More

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December 2018
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Melanoma-related changes in skin microbiome.

Folia Microbiol (Praha) 2018 Dec 15. Epub 2018 Dec 15.

Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague, Czech Republic.

Melanoma is the least common form of skin tumor, but it is potentially the most dangerous and responsible for the majority of skin cancer deaths. We suggest that the skin microbiome might be changed during the progression of melanoma. The aim of this study is to compare the composition of the skin microbiota between different locations (skin and melanoma) of a MeLiM (Melanoma-bearing Libechov Minipig) pig model (exophytic melanoma). Read More

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December 2018
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Illumina MiSeq Sequencing Investigation of Microbiota in Bronchoalveolar Lavage Fluid and Cecum of the Swine Infected with PRRSV.

Curr Microbiol 2018 Dec 15. Epub 2018 Dec 15.

Institute of Immunology, College of Life Science and Technology, Dalian University, Dalian, 116622, Liaoning, China.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant animal morbidity and mortality and economic losses worldwide. In this study, we analyzed the microbiota in bronchoalveolar lavage fluid (BAL), mucosa, and feces in cecum of the PRRSV-challenged pigs using the Illumina MiSeq sequencing platform, to investigate the role of microbiota in the pathogenesis and development of porcine reproductive and respiratory syndrome (PRRS). Quantitative insights into microbial ecology analyses indicated that the dominant bacterial groups in the lung from the PRRSV-challenged pigs were Haemophilus parasuis and Mycoplasma hyorhinis, with a relative abundance of 35-48% and 27-41%, respectively. Read More

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December 2018
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Bacterial community activity and dynamics in the biofilm of an experimental hybrid wetland system treating greywater.

Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.

Faculty of Science and Technology, University of Tartu, Vanemuise 46, 51014, Tartu, Estonia.

The objectives of this study were to determine the biofilm microbial activity and bacterial community structure and successions in greywater treatment filters and to relate the treatment efficiency to the bacterial community parameters. This 10-month study was performed in a newly established experimental system for domestic greywater treatment that consisted of three parallel vertical flow filters (VFs) followed by a horizontal flow filter (HF). A rapid increase in the bacterial community abundance occurred during the first 85 days of filter operations, followed by a short-term decrease and the stabilization of the 16S rRNA gene copy numbers at average levels of 1. Read More

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December 2018

Bacterial exopolysaccharide promotes acid tolerance in Bacillus amyloliquefaciens and improves soil aggregation.

Mol Biol Rep 2018 Dec 15. Epub 2018 Dec 15.

Department of Agricultural Biotechnology, Assam Agricultural University, Jorhat, Assam, India.

In this paper we report the isolation and taxonomic characterization of exopolysaccharide (EPS) producing bacteria followed by the role of EPS in conferring acid tolerance to the soil bacteria Bacillus amyloliquefaciens p16. The role of EPS in promoting soil aggregation is also presented. A total of 75 isolates were tested for acid tolerance and biofilm production under acid stress of which, 54 isolates were further tested for EPS production. Read More

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December 2018

Pore-forming bacteriocins: structural-functional relationships.

Arch Microbiol 2018 Dec 15. Epub 2018 Dec 15.

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences, Orenburg, Russian Federation.

Peptides and proteins are important bioorganic compounds in nature, among which a special place is occupied by antimicrobial substances. There are more than 2000 different antimicrobial peptides (AMPs) produced by a variety of living organisms. Bacteriocins produced by bacteria are the minor group, whose chemical structures are most complicated among all AMPs. Read More

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December 2018
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First prevalence of metallo beta-lactamases producing Enterobacteriacea in Iranian cancer patients.

Authors:
D Zare H Fazeli

Ann Ig 2019 Jan-Feb;31(1):62-68

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Hospital-associated infections, recently renamed Healthcare-associated infections, are among the most common life-threatening complications of hospitalized patients, especially the immunocompromised patients. Regarding the significant role of Enterobacteriaceae in nosocomial infections and also the increasing trends of carbapenem-resistant strains, the present study aimed to evaluate the antibiotic resistance pattern and the occurrence of metallo-beta-lactamases (MBLs) in Enterobacteriaceae strains from Iranian cancer patients.

Methods: This hospital-based cross-sectional study was conducted in teaching hospitals of two cities in the central parts of Iran during the 6 months period from December 2015 to May 2016. Read More

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December 2018
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Strategies to control antibiotic resistance: results from a survey in Italian children's hospitals.

Ann Ig 2019 Jan-Feb;31(1):3-12

Medical Direction, Bambino Gesù Children's Hospital, Rome, Italy.

Background: Antimicrobial stewardship programs and comprehensive infection control programs represent the main strategies to limit the emergence and transmission of multi-drug resistant bacteria in hospital settings. The purpose of this study was to describe strategies implemented in Italian children's hospitals for controlling antibiotic resistance.

Study Design: Cross sectional multicenter study. Read More

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December 2018

Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice.

Gut 2018 Dec 15. Epub 2018 Dec 15.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Objective: Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we propose that toll-like receptor 4 (TLR4)-mediated intestinal dysfunction could contribute to intestinal and central inflammation in PD-related neurodegeneration.

Design: To test this hypothesis we performed studies in both human tissue and a murine model of PD. Read More

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December 2018

Chlamydia trachomatis ct143 stimulates secretion of proinflammatory cytokines via activating the p38/MAPK signal pathway in THP-1 cells.

Mol Immunol 2018 Dec 13;105:233-239. Epub 2018 Dec 13.

Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, 410078, China.

Chlamydia trachomatis (Ct) infections can cause bacterial sexually-transmitted and preventable blindness. The Ct infections induced excessive cytokines generation which attributed to pathologic changes in host cells. However, the precise mechanisms of Ct-induced cytokines production are still unclear. Read More

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December 2018

N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines.

Bioorg Chem 2018 Dec 4;84:418-433. Epub 2018 Dec 4.

School of Chemistry, National University of Ireland Galway, University Road, Galway H91 TK33, Ireland. Electronic address:

1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the α-fucosidases of T. maritima (bacterial origin) and B. Read More

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December 2018

Non canonical genetic material.

Curr Opin Biotechnol 2018 Dec 13;57:25-33. Epub 2018 Dec 13.

KU Leuven, Rega Institute for Medical Research, Medicinal Chemistry, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

To increase the scope of natural biosystem, nucleic acids have been intensively modified. One direction includes the development of a synthetic alternative to the native DNA and RNA, denoted Xenobiotic nucleic acids (XNAs) that are able to store and transfer genetic information either by base-modification or backbone-modification. Another line of research aims to develop alternative third base pair additional to natural A:T and G:C. Read More

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December 2018

Distribution of antibiotic resistance genes in soils and crops. A field study in legume plants (Vicia faba L.) grown under different watering regimes.

Environ Res 2018 Dec 6;170:16-25. Epub 2018 Dec 6.

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, 08034 Barcelona, Spain. Electronic address:

Social concern has raised during the last years due to the development of antibiotic resistance hotspots in different environmental compartments, including the edible parts of crops. To assess the influence of the water quality used for watering, we collected samples from soil, roots, leaves and beans from the legume plant Vicia faba (broad beans) in three agricultural peri-urban plots (Barcelona, NE Spain), irrigated with either groundwater, river water, or reclaimed water. Antibiotic resistance genes (ARGs) sul1, tetM, qnrS1, blabla, mecA, and bla were quantified by real-time PCR, along with 16S rDNA and intl1 sequences, as proxies for bacterial abundance and integron prevalence, respectively. Read More

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December 2018
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Bacterial cellulose production by Acetobacter xylinum ATCC 23767 using tobacco waste extract as culture medium.

Bioresour Technol 2018 Dec 10;274:518-524. Epub 2018 Dec 10.

School of Food and Biological Engineering, Henan Provincial Collaborative Innovation Center for Food Production and Safety, Zhengzhou University of Light Industry, Dongfeng Road 5#, Zhengzhou 450002, Henan Province, China. Electronic address:

In this study, bacterial cellulose (BC) was synthesized by Acetobacter xylinum ATCC 23767 using tobacco waste extract (TWE) as a carbon source. Nicotine was found to be an inhibitory factor for BC synthesis, but it can be removed at pH 9.0 by steam distillation. Read More

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December 2018
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Frequency of superantigen encoding genes of Staphylococcus aureus isolates collected from multiple sclerosis (MS) patients and nasal carriers.

Microb Pathog 2018 Dec 13. Epub 2018 Dec 13.

Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Bacterial superantigens are potent T cell activators that can have acute or chronic effects on the central nervous system.

Objectives: In this study, the role of enterotoxins, exfoliative toxins and toxic shock syndrome toxin of Staphylococcus aureus was investigated in MS patients and healthy nasal carriers.

Methods: Three-hundred fifty nasal swabs were collected from healthy nasal carriers (n = 210) and MS (n = 140) patients. Read More

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December 2018

Reduction of stool bacterial counts and prevention of diarrhea using an oral homeopathic product in newborn lambs.

Microb Pathog 2018 Dec 13. Epub 2018 Dec 13.

Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Brazil; Graduate Program in Animal Science, UDESC, Brazil. Electronic address:

Lamb farming is generally a secondary activity for farmers, and many breeding systems suffer from management failures that impair production. One reason for decline in performance is enteritis, usually affecting newborn lambs. Enteritis can be fatal, especially in dairy herds. Read More

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December 2018
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Effect of dietary supplementation with apple cider vinegar and propionic acid on hemolymph chemistry, intestinal microbiota and histological structure of hepatopancreas in white shrimp, Litopenaeus vannamei.

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Iranian Fisheries Science Research Institute. Persian Gulf and Oman Sea Ecology Research Center, Persian Gulf Mollusks Research Station, Bandar-e- Lengeh, Iran.

This experiment was conducted to evaluate the effects of dietary supplementation of Apple cider vinegar (ACV) and propionic acid (PA) on biochemical parameters of hemolymph, intestinal microbiota and histology of hepatopancreas in white shrimp (Litopenaeus vannamei). Five experimental diets were evaluated in this study including diets supplemented with 1.0, 2. Read More

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December 2018

Food restriction, but not seasonality, modulates the acute phase response of a neotropical bat.

Comp Biochem Physiol A Mol Integr Physiol 2018 Dec 13. Epub 2018 Dec 13.

Departamento de Zoologia, Instituto de Biociências Universidade Estadual Paulista Julho de Mesquita Filho, Rio Claro, São Paulo, Brazil.

Season and food intake are known to affect immune response of vertebrates yet their effects on metabolic rate have been rarely explored. We tested the effect of season and acute food restriction and their interaction on the energetic cost of immune response activation of a tropical vertebrate, the Seba's short-tailed fruit bat (Carollia perspicillata). We specifically stimulated the acute phase response (APR) with bacterial lipopolysaccharide (LPS) to measure metabolic changes along with changes in body temperature (T), body mass (M), white blood cell counts and the Neutrophil/Lymphocyte ratio (N/L). Read More

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December 2018

Structural and functional characterization of a family GH53 β-1,4-galactanase from Bacteroides thetaiotaomicron that facilitates degradation of prebiotic galactooligosaccharides.

J Struct Biol 2018 Dec 13. Epub 2018 Dec 13.

Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Nijenborgh 7, 9747AG Groningen, The Netherlands. Electronic address:

Galactooligosaccharides (GOS) are prebiotic compounds synthesized from lactose using bacterial enzymes and are known to stimulate growth of beneficial bifidobacteria in the human colon. Bacteroides thetaiotaomicron is a prominent human colon commensal bacterial species that hydrolyzes GOS using an extracellular Glycosyl Hydrolase (GH) family GH53 endo-galactanase enzyme (BTGH53), releasing galactose-based products for growth. Here we dissect the molecular basis for GOS activity of this B. Read More

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December 2018

Virulence and resistance determinants of Klebsiella pneumoniae isolated from a Portuguese tertiary university hospital centre over a 31-year period.

Enferm Infecc Microbiol Clin 2018 Dec 12. Epub 2018 Dec 12.

Microbiology and Immunology Department, Interdisciplinary Research Centre Egas Moniz (CiiEM), Faculty of Pharmacy, University of Lisbon, 1649-003, Lisbon, Portugal.

Introduction: The rapid and complex evolution of bacterial resistance mechanisms in Klebsiella pneumoniae producing extended-spectrum β-lactamases and carbapenemases in Klebsiella pneumoniae is one of the most significant threats to public health. However, questions and controversies regarding the interactions between resistance and virulence in multidrug-resistant K. pneumoniae isolates remain unclear. Read More

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December 2018
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The group I GH3 family genes encoding JA-Ile synthetase act as positive regulator in the resistance of rice to Xanthomonas oryzae pv. oryzae.

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan 430070, China. Electronic address:

Plant GH3 genes are key components of the hormonal mechanism regulating growth and development, responding to biotic and abiotic stress. GH3 proteins are involved in hormonal homeostasis through conjugation to amino acids of the free form of salicylic acid, jasmonic acid (JA) or indole-3-acetic acid (IAA). Our previous work has uncovered that two GH3 genes encoding IAA-amido synthetase play important roles in the resistance to bacterial blight caused by Xanthomonas oryzae pv. Read More

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December 2018

Physicochemical surface properties of bacterial cellulose/polymethacrylate nanocomposites: an approach by inverse gas chromatography.

Carbohydr Polym 2019 Feb 31;206:86-93. Epub 2018 Oct 31.

LB3, Faculty of Exact Science and Engineering, University of Madeira, 9000-390 Funchal, Portugal; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, University of Porto, 4450-208, Porto, Portugal. Electronic address:

Nanocomposites of poly(glycidyl methacrylate) and bacterial cellulose (BC), or poly(poly(ethylene glycol) methacrylate) and BC were produced via the in-situ polymerization of methacrylic monomers, inside the BC 3D network. The nanocomposites surface properties were evaluated by inverse gas chromatography (IGC). The dispersive component of surface energy (γ) varied between 35. Read More

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February 2019

Microwave assisted κ-carrageenan capped silver nanocomposites for eradication of bacterial biofilms.

Carbohydr Polym 2019 Feb 14;206:854-862. Epub 2018 Nov 14.

Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India. Electronic address:

Maturation of bacterial biofilms and their resistance to recurrent antimicrobial agents results in convoluted infectious diseases. In the current study, kappa-Carrageenan (κ-Carrageenan/CRG), was used to formulate CRG-silver nanocomposites through a facile microwave green synthesis approach. CRG-Ag nanoparticles of size 50 ± 10 nm were obtained by using CRG as a reducing and stabilizing agent. Read More

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February 2019

Synthesis of highly stable bacterial cellulosic pocket for drug storage.

Carbohydr Polym 2019 Feb 17;206:625-632. Epub 2018 Nov 17.

Key Laboratory of Eco-Textiles, Ministry of Education, Jiangnan University, Wuxi 214122, China. Electronic address:

Inulin was introduced to the fructose permeates of Gluconacetobacter xylinus (ATCC 10,245) bacterial strain to successfully synthesize empty cellulosic pockets for possible drug storage. FTIR Spectroscopy analysis confirmed a slight variation in the hydrogen bonds at 2893 cm due to CH and CH stretching whiles Conformational analysis revealed that inulobiose extending all-trans conformation corresponded to φ = Ψ = ω  = 180°. Fructofuranose moiety, the anomeric carbon was defined as C2. Read More

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February 2019

Characterization of PVA/cassava starch biocomposites fabricated with and without sonication using bacterial cellulose fiber loadings.

Carbohydr Polym 2019 Feb 19;206:593-601. Epub 2018 Nov 19.

Laboratory of Focused Ion Beam, Research Center for Physics Indonesian Institute of Sciences (LIPI) Serpong, Indonesia.

This paper reports the characterization of polyvinyl alcohol (PVA)/cassava starch biocomposites. The cassava starch gel with or without ultrasonic probe treatment was mixed with PVA gel then short bacterial cellulose fibers were added. The presence of the sonicated starch gel in the PVA resulted in low thermal and moisture resistance, and low transparency of the blend film. Read More

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February 2019

Development of modified montmorillonite-bacterial cellulose nanocomposites as a novel substitute for burn skin and tissue regeneration.

Carbohydr Polym 2019 Feb 13;206:548-556. Epub 2018 Nov 13.

Biotechnology Program, Department of Environmental Sciences, COMSATS University Islamabad, Abbottabad Campus 22060, Pakistan. Electronic address:

Bacterial cellulose (BC) is a promising biopolymer with wound healing and tissue regenerative properties but lack of antimicrobial property limits its biomedical applications. Therefore, current study was proposed to combine wound healing property of BC with antimicrobial activity of montmorillonite (MMT) and modified montmorillonites (Cu-MMT, Na-MMT and Ca-MMT) to design novel artificial substitute for burns. Designed nanocomposites were characterized through Fe-SEM, FTIR and XRD. Read More

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February 2019
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Inhibition of bacterial adhesion and biofilm formation of sulfonated chitosan against Pseudomonas aeruginosa.

Carbohydr Polym 2019 Feb 10;206:412-419. Epub 2018 Nov 10.

Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huaian 223003, PR China.

The exploitation of chitosan derivatives as safe and natural polymers against microorganisms has been reconsidered as an alternative to antibiotics and chemical preservatives. Herein, inhibition of bacterial adhesion and biofilm formation by anionic chitosan (sulfonated chitosan, SCS) and cationic chitosan (chitosan hydrochloride, WCS) against P. aeruginosa were investigated. Read More

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February 2019

Soluble xyloglucan generates bigger bacterial community shifts than pectic polymers during in vitro fecal fermentation.

Carbohydr Polym 2019 Feb 10;206:389-395. Epub 2018 Nov 10.

Whistler Center for Carbohydrate Research and Department of Food Science, Purdue University, West Lafayette, USA. Electronic address:

Xyloglucans and pectic polymers can be obtained from a variety of plants ubiquitous in the human diet, however, their fermentability in the colon and consequent nutritional benefits are poorly understood. Here, we evaluated metabolite profiles and bacterial shifts during in vitro fecal fermentations of two isolated pectic polymers and a xyloglucan. Depending on their chemical structure, pectic polymers were more acetogenic or propiogenic. Read More

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February 2019

Influence of acid depolymerization parameters on levan molar mass distribution and its utilization by bacteria.

Carbohydr Polym 2019 Feb 13;206:371-379. Epub 2018 Nov 13.

Department of Fermentation and Biosynthesis, Institute of Food Technology of Plant Origin, Poznań University of Life Sciences, ul. Wojska Polskiego 31, 60-624 Poznań, Poland. Electronic address:

Levan is a fructan composed of β -(2, 6) linkages in its main chain. Its health properties, especially its prebiotic potential can be partially modified by changing its molar mass distribution. Given that native levan is rarely fermented by probiotic bacteria, especially lactic acid bacteria (LAB), levanoligosaccharides (LOS) were produced by mild acid hydrolysis. Read More

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February 2019

Smart wound dressing based on κ-carrageenan/locust bean gum/cranberry extract for monitoring bacterial infections.

Carbohydr Polym 2019 Feb 12;206:362-370. Epub 2018 Nov 12.

Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, 88701-000, Tubarão, SC, Brazil.

A smart wound dressing based on carrageenan (κC), locust bean gum (LBG), and cranberry extract (CB) for monitoring bacterial wound infections was developed and characterized using UV-vis spectroscopy, FT-IR, and SEM. The mechanical, swelling, cytotoxic and pH sensor properties were also investigated. UV-vis spectra demonstrated that the obtained κC:LBG:CB hydrogel film exhibited a visible change of colors as it was immersed in PBS solution pH 5. Read More

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February 2019

Effects of nanocellulose on sodium alginate/polyacrylamide hydrogel: Mechanical properties and adsorption-desorption capacities.

Carbohydr Polym 2019 Feb 30;206:289-301. Epub 2018 Oct 30.

College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China; Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing 210042, Jiangsu, China.

In this study, interpenetrating polymer network (IPN)-structured hydrogels were fabricated through the crosslinking of neutral polyacrylamide (PAM, the first flexible network) and the polyelectrolyte sodium alginate (SA, the second rigid network). Three types of nanocellulose, including cellulose nanocrystals (CNCs), bacterial cellulose fibers (BCs) and 2,2,6,6-tetramethylpiperidine-1-oxy radical (TEMPO)-oxidized cellulose nanofibers (TOCNs), were well-dispersed in the SA-PAM gel matrix. The hydrogels, obtained with a high water content (∼83%), exhibit a macroporous structure with a mean pore size of 60 ± 51 μm and high transparency. Read More

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February 2019

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application.

Carbohydr Polym 2019 Feb 25;206:187-197. Epub 2018 Oct 25.

CICECO, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. Read More

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February 2019
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Mucoadhesive guargum hydrogel inter-connected chitosan-g-polycaprolactone micelles for rifampicin delivery.

Carbohydr Polym 2019 Feb 29;206:1-10. Epub 2018 Oct 29.

Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, 625021, India. Electronic address:

Natural polymer guar gum has one of the highest viscosities in water solution and hence, these are significantly used in pharmaceutical applications. Guar gum inter-connected micelles as a new carrier has been developed for poor water soluble rifampicin drug. The hydrogel inter-connected micelle core was formulated as a hydrophilic inner and hydrophobic outer core by using guar gum/chitosan/polycaprolactone and the carrier interaction with rifampicin was confirmed by FT-IR. Read More

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February 2019

Molecular characterization and antimicrobial susceptibility of Staphylococcus aureus isolated from children with acute otitis media in Liuzhou, China.

BMC Pediatr 2018 Dec 15;18(1):388. Epub 2018 Dec 15.

Children's Hospital of Michigan, Detroit, MI, USA.

Background: There have been few studies focused on the prevalence, bacterial etiology, antibiotic resistance, and genetic background of Staphylococcus aureus (S. aureus) in children with acute otitis media (AOM) in China.

Methods: A retrospective study was conducted in Liuzhou Maternity and Child Healthcare Hospital. Read More

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December 2018

Functionalized rifampicin-loaded nanostructured lipid carriers enhance macrophages uptake and antimycobacterial activity.

Colloids Surf B Biointerfaces 2018 Dec 4;175:306-313. Epub 2018 Dec 4.

Laboratório de Fitotecnologia, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil. Electronic address:

Tuberculosis is an infectious bacterial disease that causes millions of deaths worldwide. Current treatment recommended by WHO is effective, however it is an extensive and arduous process associated to severe adverse effects, which induces a low patient compliance and the emerging of multidrug resistant tuberculosis. Thus, as a main goal of this study, rifampicin nanoparticles were surface functionalized with a tuftsin-modifed peptide to selectively recognize receptors located on infected alveolar macrophages, enhancing nanoparticles uptake by these cells and improving antimycobacterial activity. Read More

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December 2018
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Influence of the T to S mutation at the STMK motif on antibiotic resistance of penicillin binding protein 1A: A comprehensive computational study.

J Mol Graph Model 2018 Dec 7;87:185-191. Epub 2018 Dec 7.

Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

The emergence of antibiotic resistance has attracted the attention of scientists and scientific circles over the decades. β-Lactam antibiotics resistance is a worldwide therapeutic challenge in bacterial infections, mediated through several mechanisms of which mutations in Penicillin Binding Proteins (PBPs) are an important issue, making critical therapeutic problems in the human population. Accordingly, investigating the dynamic structures of mutant variants could result in a profound understanding of such a specific resistance. Read More

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December 2018

Housefly larvae (Musca domestica) significantly accelerates degradation of monensin by altering the structure and abundance of the associated bacterial community.

Ecotoxicol Environ Saf 2018 Dec 12;170:418-426. Epub 2018 Dec 12.

College of Veterinary Medicine, China Agricultural University, No. 2 Yuan Ming Yuan West Road, Hai Dian District, Beijing 100193, China. Electronic address:

Vermicomposting of livestock manure using housefly larvae is a promising biotechnology for waste reduction and control of antibiotic pollution. Monensin (MON), an ionophore polyether antibiotic (IPA), is widely used in broiler feed to control coccidiosis. However, MON residues in litter have become a major source of pollution in the environment. Read More

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December 2018
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Efficacy and safety of partial splenic embolization for hypersplenism in pre- and post-liver transplant patients: A 16-year comparative analysis.

Clin Imaging 2018 Nov 27;54:71-77. Epub 2018 Nov 27.

Department of Radiology, Division of Vascular and Interventional Radiology, Columbia University Medical Center, 177 Fort Washington Ave, Milstein Hospital - 4 Hudson North, New York, NY 10032, United States of America.

Purpose: To report the effect of partial splenic embolization (PSE) on hematological indices and the procedure's safety in pre- and post-liver transplant (LT) patients.

Materials And Methods: A single-center retrospective study evaluating all patients who underwent PSE over a 16-year period was performed. Inclusion criteria were splenomegaly confirmed by imaging and at least one of the following cytopenias: hemoglobin ≤10 g/dL, WBC count ≤1500 μL, or platelet count ≤100,000 μL. Read More

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November 2018
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Draft genome sequence of human-associated streptogramin resistant Staphylococcus aureus.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Bacterial Epidemiology and Antimicrobial Resistance Research Unit, USDA-ARS, Athens, Georgia, USA. Electronic address:

Objectives: Staphylococcus aureus is one of the leading causes of nosocomial and community-acquired infections. Treatment of those infections with macrolide-lincosamide-streptogramin (MLS) antibiotics has led to resistance to those antibiotics through various mechanisms. S. Read More

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December 2018
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Establishing a decision-support system for eco-design of biological wastewater treatment: A case study of bioaugmented constructed wetland.

Bioresour Technol 2018 Dec 7;274:425-429. Epub 2018 Dec 7.

Section of Sanitary Engineering, Department of Water Management, Delft University of Technology, Delft 2628CN, The Netherlands; Veolia Water Technologies Techno Center Netherlands B.V., Tanthofdreef 21, 2623 EW Delft, The Netherlands.

Deep treatment is a common approach to enhance pollutant removal for biological wastewater treatment technologies (BWTTs), and life cycle assessment (LCA) holds substantial advantages to support process optimization. However, there lacks of LCA-based benchmarks that cover human-nature nexuses and stakeholder involvement, which limits the guidance and eco-design of BWTTs. This study proposed a decision-support system (DSS) by linking LCA with Water Quality Model and Conjoint Analysis. Read More

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December 2018
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Key role of cyromazine in the distribution of antibiotic resistance genes and bacterial community variation in aerobic composting.

Bioresour Technol 2018 Dec 3;274:418-424. Epub 2018 Dec 3.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, China.

The risks that have not been noted so far have come from the use of non-antibiotics. In this study, non-antibiotic drug (cyromazine) was used in composting to investigate its possible effects on the distribution of ARGs and changes of bacterial community. Results showed that cyromazine increased the abundances of highly-risky ARGs (bla and bla), and heavy metal resistance genes (MRGs). Read More

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December 2018
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4.494 Impact Factor

Improved SILAC method for double labeling of bacterial proteome.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address:

Stable isotope labeling with amino acids in cell culture (SILAC) is a robust proteomics method with advantages such as reproducibility and easy handling. This method is popular for the analysis of mammalian cells. However, amino acid conversion in bacteria decreases the labeling efficiency and quantification accuracy, limiting the application of SILAC in bacterial proteomics to auxotrophic bacteria or to single labeling with lysine. Read More

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December 2018
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Epidemiology and etiology of diarrhea in UK military personnel serving on the United Nations Mission in South Sudan in 2017: A prospective cohort study.

Travel Med Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Academic Department of Military Medicine, Medical Directorate, Defence Medical Services, Birmingham, UK.

Background: . Diarrhea is a well-established problem in travellers, with military personnel at especially high risk. This study aimed to characterise the spectrum of pathogens causing diarrhea in UK military personnel in South Sudan, and assess the utility of culture-independent testing for etiology and antimicrobial resistance in a logistically challenging and austere environment. Read More

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December 2018
1.538 Impact Factor

Variety matters: Diverse functions of monocyte subtypes in vascular inflammation and atherogenesis.

Vascul Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Cardiology and Angiology, Philipps-University Marburg, Marburg, Germany. Electronic address:

Monocytes are important mediators of the innate immunity by recognizing and attacking especially bacterial pathogens but also play crucial roles in various inflammatory diseases, including vascular inflammation and atherosclerosis. Maturation, differentiation and function of monocytes have been intensively explored for a long time in innumerable experimental and clinical studies. Monocytes do not represent a uniform cell type but could be further subdivided into subpopulations with distinct features and functions. Read More

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December 2018

The role of the wzy gene in lipopolysaccharide biosynthesis and pathogenesis of avian pathogenic Escherichia coli.

Microb Pathog 2018 Dec 12. Epub 2018 Dec 12.

Shanghai Veterinary Research Institute, The Chinese Academy of Agricultural Sciences (CAAS), 518 Ziyue Road, Shanghai, 200241, PR China. Electronic address:

Avian pathogenic Escherichia coli (APEC) causes severe respiratory and systemic diseases in poultry. The wzy gene encodes the O-antigen polymerase (Wzy), which plays an important role in the synthesis of the lipopolysaccharide (LPS) of bacteria. However, the function of the wzy gene in APEC remains unclear. Read More

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December 2018

Evaluation of antioxidant and antimicrobial potential of a novel Himalayan plant Reinwardtia indica dumort: Scientifically unexplored.

Microb Pathog 2018 Dec 12. Epub 2018 Dec 12.

Department of Kriyasharir Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.

Reinwardtia indica (Lineceae) is a medicinal plant cultivated in the Himalayan region. It is effectively used in folk medicines for the treatment of various health complications. In the present study, the shade dried leaves and stem were extracted in three different solvents such as ethyl acetate, ethanol, and hydro-alcoholic. Read More

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December 2018

Chitosan-hydroxypropyl methylcellulose tioconazole films: A promising alternative dosage form for the treatment of vaginal candidiasis.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Instituto de Química Rosario (IQUIR, CONICET-UNR), Suipacha 531, Rosario S2002LRK, Argentina; Área Técnica Farmacéutica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario S2002LRK, Argentina. Electronic address:

Vaginal candidiasis is considered a frequent opportunistic mucosal infection and the second most common cause of vaginitis after bacterial vaginosis. In this work, different vaginal films based on chitosan, hydroxypropyl methylcellulose and blends of these polymers containing tioconazole, were developed and thoroughly characterized to improve the conventional therapeutics of vaginal candidiasis. Mechanical properties, swelling, adhesiveness, morphology, antifungal activity, hemocompatibility and cytotoxicity were evaluated. Read More

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December 2018
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