1,396 results match your criteria Bacterial Overgrowth Syndrome


Fecal microbiome alterations in pediatric patients with short bowel syndrome receiving a rotating cycle of gastrointestinal prophylactic antibiotics.

Pediatr Surg Int 2021 Jun 22. Epub 2021 Jun 22.

Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, 90110, Songkhla, Thailand.

Background: Pediatric patients with short bowel syndrome (SBS) are at risk of developing small intestinal bacterial overgrowth (SIBO). Prevention of SIBO using cyclic enteric antibiotics has been implemented to control the balance in microbial ecosystems, although its effectiveness has not been well studied.

Purpose: This study aimed to explore the change in the gut microbial composition in SBS patients during cyclic antibiotic phases and antibiotic-free period, and to compare the microbiota composition between healthy controls and SBS patients. Read More

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Perforated Blind Pouch: An Unusual Late Complication Following Lateral Anastomosis After a Right Hemicolectomy.

Cureus 2021 May 15;13(5):e15044. Epub 2021 May 15.

Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Blind loop syndrome (BLS) is a well-recognized delayed complication in small bowel strictures, stenosis, fistulas, diverticula, or post-gastrectomy afferent loop syndrome. However, due to its delayed presentation, BLS after side-to-side bowel anastomosis is inadequately reported. The vicious cycle of the blind loop is due to bacterial overgrowth, resulting in diarrhea, weight loss, malnutrition, and rarely mucosal erosion, bleeding, and perforation peritonitis. Read More

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Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis.

Gastroenterology 2021 Jun 16. Epub 2021 Jun 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria. Electronic address:

Background & Aims: Irritable bowel syndrome (IBS) and inflammatory bowel diseases result in a substantial reduction in quality of life and a considerable socio-economic impact. In IBS, diagnosis and treatment options are limited, but evidence for an involvement of the gut microbiome in disease pathophysiology is emerging. Here we analyzed the prevalence of endoscopically visible mucosal biofilms in gastrointestinal disease and associated changes in microbiome composition and metabolism. Read More

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Agrobacterium rhizogenes rolB oncogene: An intriguing player for many roles.

Plant Physiol Biochem 2021 Aug 14;165:10-18. Epub 2021 May 14.

Dipartimento di Biologia, Università degli Studi di Firenze, via Madonna del Piano 6, 50019, Sesto f.no, FI, Italy. Electronic address:

The rolB oncogene is one of the so-called rol genes found in the T-DNA region of the Agrobacterium rhizogenes Ri plasmid and involved in the hairy root syndrome, a tumour characterized by adventitious root overgrowth on plant stem. rolB produces in plants a peculiar phenotype that, together with its root-inducing capacity, has been connected to auxin sensitivity. The gene is able to modify the plant genetic programme to induce meristem cells and direct them to differentiate not only roots, but also other cells, tissues or organs. Read More

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Small Intestinal Bacterial Overgrowth.

Gastroenterol Clin North Am 2021 Jun 23;50(2):463-474. Epub 2021 Apr 23.

Division of Gastroenterology and Hepatology, Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital, 6550 Fannin Street Suite 1201, Houston, TX 77030, USA.

The term "small intestinal bacterial overgrowth" (SIBO) has been used to refer to a disorder resulting from the colonization of the small bowel by an increased number of microorganisms or by the presence of bacteria that are not usual constituents of this part of the gastrointestinal tract. Clinical presentations, often in patients with certain risk factors, can range from a full-blown malabsorption syndrome to such "functional" complaints as bloating and flatulence. SIBO is diagnosed by either culture of a small bowel aspirate or one of several breath tests. Read More

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D-lactic acidosis presenting as metabolic encephalopathy in a patient with short bowel syndrome.

BMJ Case Rep 2021 May 13;14(5). Epub 2021 May 13.

Department of Gastroenterology, Galway University Hospital, Galway, Ireland.

We present a case of D-lactic acidosis presenting as a metabolic encephalopathy secondary to small intestinal bacterial overgrowth. This patient had a known history of short bowel syndrome. Of note, this case required the alteration of treatment to promote a sustained clinical and biochemical improvement. Read More

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Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome.

World J Gastroenterol 2021 Apr;27(15):1643-1654

Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: In the early stage of acute pancreatitis (AP), a large number of cytokines induced by local pancreatic inflammation seriously damage the intestinal barrier function, and intestinal bacteria and endotoxins enter the blood, causing inflammatory storm, resulting in multiple organ failure, infectious complications, and other disorders, eventually leading to death. Intestinal failure occurs early in the course of AP, accelerating its development. As an alternative method to detect small intestinal bacterial overgrowth, the hydrogen breath test is safe, noninvasive, and convenient, reflecting the number of intestinal bacteria in AP indirectly. Read More

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Antibiotic treatment for small intestinal bacterial overgrowth: Is a cocktail better than a single?

Authors:
Uday C Ghoshal

United European Gastroenterol J 2021 May 5. Epub 2021 May 5.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, India.

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Proteomic biomarkers in short bowel syndrome : are we ready to use them in clinical activity?

Expert Rev Proteomics 2021 Apr 16;18(4):285-293. Epub 2021 May 16.

Department of Surgical Sciences, La Sapienza University, Rome, Italy.

: Short bowel syndrome (SBS) is a clinical condition that can affect childhood and adult patients. Biomarker research is expected to be a new frontier in the clinical application, helpful for patients and health-care systems.: SBS is usually a consequence of a massive intestinal resection that leads to an intestinal failure because of the reduction of absorptive surface, bacterial overgrowth, and faster intestinal transit. Read More

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One dog's waste is another dog's wealth: A pilot study of fecal microbiota transplantation in dogs with acute hemorrhagic diarrhea syndrome.

PLoS One 2021 19;16(4):e0250344. Epub 2021 Apr 19.

Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.

Canine acute hemorrhagic diarrhea syndrome (AHDS) has been associated in some studies with Clostridioides perfringens overgrowth and toxin-mediated necrosis of the intestinal mucosa. We aimed to determine the effect of a single fecal microbiota transplantation (FMT) on clinical scores and fecal microbiomes of 1 and 7 dogs with AHDS from New Zealand and South Africa. We hypothesized that FMT would improve AHDS clinical scores and increase microbiota alpha-diversity and short-chain fatty acid (SCFA)-producing microbial communities' abundances in dogs with AHDS after FMT. Read More

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Correlation between small intestinal bacterial overgrowth and irritable bowel syndrome and the prognosis of treatment.

Ann Palliat Med 2021 Mar;10(3):3364-3370

Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China; Department of Anorectal Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Background: The aim of the present study was to analyze the relationship between small intestinal bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS) and the prognosis of treatment.

Methods: A total of127 IBS patients (IBS group) were selected, and based on the results of the methane/hydrogen breath test, they were divided into SIBO-positive group (subdivided into the antibiotic group, microecological group, and placebo group according to difference in treatment methods) and the SIBO-negative group. The incidence of SIBO and inflammatory factors in different populations were compared. Read More

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Effects of Bovine Colostrum with or without Egg on In Vitro Bacterial-Induced Intestinal Damage with Relevance for SIBO and Infectious Diarrhea.

Nutrients 2021 Mar 22;13(3). Epub 2021 Mar 22.

Centre of Immunobiology, Blizard Institute, Barts and The London School of Medicine, Queen Mary, University of London, London E1 2AT, UK.

Small intestinal bacterial overgrowth (SIBO) occurs commonly, is difficult to treat, and frequently recurs. Bovine colostrum (BC) and chicken eggs contain immunoglobulins and other components that possess antimicrobial, immunoregulatory, and growth factor activities; however, it is not known if they have the ability to reduce injury caused by the presence of bacteria associated with SIBO (, , , , , , and ) and infectious diarrhea (enteropathogenic , ). We examined the effects of BC, egg, or the combination, on bacterial growth and bacteria-induced changes in transepithelial electrical resistance (TEER) and bacterial translocation across confluent Caco-2 monolayers. Read More

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Understanding the Effects of Gut Microbiota Dysbiosis on Nonalcoholic Fatty Liver Disease and the Possible Probiotics Role: Recent Updates.

Int J Biol Sci 2021 8;17(3):818-833. Epub 2021 Feb 8.

School of Life Sciences, Probiotics and Biological Feed Research Centre, Lanzhou University, Lanzhou 730000, PR China.

Nonalcoholic fatty liver disease (NAFLD) is leading chronic liver syndrome worldwide. Gut microbiota dysbiosis significantly contributes to the pathogenesis and severity of NAFLD. However, its role is complex and even unclear. Read More

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February 2021

[Prevalence of small bowel bacterial overgrowth in patients with functional dyspepsia: a meta-analysis].

Ter Arkh 2020 Dec 15;92(12):53-58. Epub 2020 Dec 15.

Yevdokimov Moscow State University of Medicine and Dentistry.

Aim: Systematization of data on the frequency of detection of the syndrome of bacterial overgrowth in the small intestine (SIBO) in patients with functional dyspepsia (FD).

Materials And Methods: MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar, the Russian Science Citation Index (RSCI) through July 2020 were searched to identify studies evaluating the prevalence of SIBO in FD. In addition, a search for relevant abstracts was carried out in the electronic databases of the United European Gastroenterology Week (UEG), American College of Gastroenterology (ACG), International Conference on Nutrition and Food (ICNF). Read More

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December 2020

The Roles of Lactobacillus Acidophilus and Pectin in Preventing Postoperative Sepsis and Intestinal Adaptation in a Rat Model of Short Bowel Syndrome.

Probiotics Antimicrob Proteins 2021 Mar 14. Epub 2021 Mar 14.

Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

One of the primary causes of morbidity and mortality in those with short bowel syndrome (SBS) is sepsis, caused by bacterial translocation (BT). Since synbiotics can cease gut-related bacterial overgrowth, they may serve as a supportive dietary supplement-based strategy after gastrointestinal surgery. This study was conducted to determine the effects of Lactobacillus acidophilus and pectin on BT and gut adaptation after extensive small bowel resection in the rat. Read More

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[The role of intraepithelial lymphocytes in pathogenesis of small intestinal bacterial overgrowth syndrome].

Pol Merkur Lekarski 2021 Feb;49(289):23-27

Medical University of Lodz, Poland: Department of Clinical Nutrition and Gastroenterological Diagnostics.

Small intestinal bacterial overgrowth (SIBO) is a frequent cause of chronic abdominal complaints. So far, a lot information has been gathered on its pathogenesis but are still doubts that raise question why its causes chronic diarrhea in some and constipation in other patients.

Aim: The aim of the study was to assess the number of endothelial lymphocytes (IELs) in the duodenal and ileum mucosa in patients with SIBO with dominant diarrhea (SIBO-D) and dominant constipation (SIBO-C). Read More

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February 2021

Revision of a Previous Capella Bypass due to dysphagia, GERD and Candy Cane Syndrome.

Obes Surg 2021 May 18;31(5):2348-2349. Epub 2021 Feb 18.

Department of General and Digestive Surgery, Fuenlabrada University Hospital, Camino del Molino, 2, Fuenlabrada, 28942, Spain.

Background: Capella ringed gastric bypass is a technical variant of gastric bypass which seeks to improve long-term outcomes with a greater restriction. Frequent complications are due to the band, due to its inclusion or slippage, without being able to reject others. Our purpose is to present the video of a revisional bariatric surgery made by laparoscopic approach in a patient with a previous open retrogastric retrocolic Capella gastric bypass. Read More

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The trimebutine effect on Helicobacter pylori-related gastrointestinal tract and brain disorders: A hypothesis.

Neurochem Int 2021 03 31;144:104938. Epub 2021 Jan 31.

Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, 546 42, Macedonia, Greece. Electronic address:

The localization of bacterial components and/or metabolites in the central nervous system may elicit neuroinflammation and/or neurodegeneration. Helicobacter pylori (a non-commensal symbiotic gastrointestinal pathogen) infection and its related metabolic syndrome have been implicated in the pathogenesis of gastrointestinal tract and central nervous system disorders, thus medications affecting the nervous system - gastrointestinal tract may shape the potential of Helicobacter pylori infection to trigger these pathologies. Helicobacter pylori associated metabolic syndrome, by impairing gut motility and promoting bacterial overgrowth and translocation, might lead to brain pathologies. Read More

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Rosacea, Germs, and Bowels: A Review on Gastrointestinal Comorbidities and Gut-Skin Axis of Rosacea.

Adv Ther 2021 03 28;38(3):1415-1424. Epub 2021 Jan 28.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Rosacea is a chronic inflammatory disease with complicated pathophysiology that involves genetic and environmental elements and dysregulation of innate and adaptive immunity, neurovascular responses, microbiome colonization or infection, resulting in recurrent inflammation. Rosacea has been reported associated with various gastrointestinal diseases including inflammatory bowel disease, celiac disease, irritable bowel syndrome, gastroesophageal reflux disease, Helicobacter pylori (HP) infection, and small intestine bacterial overgrowth (SIBO). The link may involve common predisposing genetic, microbiota, and immunological factors, comprising the theory of the gut-skin axis. Read More

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An overview of the current management of short-bowel syndrome in pediatric patients.

Surg Today 2021 Jan 19. Epub 2021 Jan 19.

Department of Pediatric Surgery, Research Field Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Kagoshima, Japan.

Short-bowel syndrome (SBS) is defined as a state of malabsorption after resection or loss of a major portion of the bowel due to congenital or acquired factors. This article presents an overview on the recent management of pediatric SBS. The pediatric SBS population is very heterogeneous. Read More

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January 2021

[Mechanism of gut-microbiota-liver axis in the pathogenesis of intestinal failure-associated liver disease].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Jan;24(1):94-100

Department of General Surgery, Nanjing Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210002, China.

Intestinal failure (IF) is defined as the critical reduction of functional intestines below the minimum needed to absorb nutrients and fluids, so that intravenous supplementation with parenteral nutrition (PN) is required to maintain health and/or growth. Although the benefits are evident, patients receiving PN can suffer from serious cholestasis due to lack of enteral feeding and small intestinal bacterial overgrowth (SIBO). One such complication that may arise is intestinal failure-associated liver disease (IFALD). Read More

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January 2021

Impact of the Synbiotics and Urate-Lowering Therapy on Gut Microbiota and Cytokine Profile in Patients with Chronic Gouty Arthritis.

J Med Life 2020 Oct-Dec;13(4):490-498

Department of Internal Medicine No.1, Bogomolets National Medical University.

The main goal of our study is the impact evaluation of complex urate-lowering therapy with the synbiotic addition on fecal microbiota and cytokine profile in patients with primary gout. During our study, 130 men (mean age 55.5 ± 9. Read More

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January 2021

Every Breath Test You Take: Practical Advice on Breath Testing Used to Detect Small Intestinal Bacterial Overgrowth.

Dig Dis Sci 2021 02 11;66(2):331-333. Epub 2021 Jan 11.

Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. S.W., Charlton Building, Rm. 8-110, Rochester, MN, 55905, USA.

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February 2021

Chinese herbal medicine for the treatment of small intestinal bacterial overgrowth (SIBO): A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Dec;99(51):e23737

The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang City, Hebei, China.

Background: Chinese medicine has a unique theory and the Chinese herbal medicine treatment is based on the integral concepts and syndrome differentiation of the Traditional Chinese Medicine system. Although antibiotics remain the mainstay of SIBO treatment, various alternative or adjunctive therapies are available, including prokinetic agents, dietary interventions, probiotics, and herbal combinations. There is accumulating evidence demonstrating the antimicrobial properties of a growing number of herbs including garlic, black cumin, cloves, cinnamon, thyme, all-spices, bay leaves, mustard, and rosemary. Read More

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December 2020

Lactose Sensitivity and Lactose Malabsorption: The 2 Faces of Lactose Intolerance.

J Neurogastroenterol Motil 2021 Apr;27(2):257-264

Department of Gastroenterology, Avicenne Hospital, Bobigny, France.

Background/aims: Self-reported lactose intolerance (LI) is frequent in patients with functional bowel disorders (FBD) that could be interpreted as irritable bowel syndrome (IBS). The present study aims to characterize the responses of patients with FBD, without small intestinal bacterial overgrowth (SIBO), and LI, in terms of lactose malabsorption (LM) and lactose sensitivity (LS) according to psychological and clinical features.

Methods: One hundred and fifty-eight consecutive FBD outpatients with LI, and no SIBO, were classified according to the Rome III questionnaire and filled Beck Depression Inventory, and State and Trait Anxiety questionnaires. Read More

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Antibiotic Stewardship Through Standardized Diagnosis and Treatment of Small Bowel Bacterial Overgrowth in Pediatric Patients With Short Bowel Syndrome Reduces Antibiotic Exposure and Improves Cost of Health Care.

J Dr Nurs Pract 2020 11;13(3):187-194

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Background: Small bowel bacterial overgrowth (SBBO) is difficult to diagnose in pediatric patients with short bowel syndrome due to the invasive nature of the gold standard testing. Alternative testing methods also have barriers leaving providers to diagnose clinically. This has led to antibiotic overprescribing in this population. Read More

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November 2020

The association between non-alcoholic fatty liver disease (with or without metabolic syndrome) and extrahepatic cancer development.

J Gastroenterol Hepatol 2020 Nov 17. Epub 2020 Nov 17.

Department of Medicine, St. Luke's International Hospital, Tokyo, Japan.

Background And Aim: This study was designed to determine whether non-alcoholic fatty liver disease (NAFLD), with or without metabolic syndrome (MetS), is a risk factor for cancer development.

Methods: We conducted a retrospective longitudinal study at the Center for Preventive Medicine, St. Luke's International Hospital. Read More

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November 2020

The overlap between irritable bowel syndrome and organic gastrointestinal diseases.

Lancet Gastroenterol Hepatol 2021 02 13;6(2):139-148. Epub 2020 Nov 13.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, NC, USA.

Irritable bowel syndrome (IBS) is a common functional bowel disorder characterised by symptoms of recurrent abdominal pain associated with a change in bowel habit. This condition is one of the most frequent reasons to seek a gastroenterology consultation in primary and secondary care. The diagnosis of IBS is made by identifying characteristic symptoms, as defined by the Rome criteria, and excluding organic gastrointestinal diseases that might otherwise explain these symptoms. Read More

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February 2021

Hydrogen and methane breath test results are negatively associated with IBS and may reflect transit time in post-surgical patients.

Neurogastroenterol Motil 2021 Jun 12;33(6):e14033. Epub 2020 Nov 12.

Department of Gastroenterology, Salford Royal Hospital, Salford, UK.

Background: Contention surrounds hydrogen and methane breath tests as putative measures of small intestinal bacterial overgrowth. We aimed to explore the clinical characteristics associated with positive and negative results to help clarify their role.

Methods: 525 glucose hydrogen/methane breath tests completed over 3 years were analyzed to look for positively and negatively associated predictive factors. Read More

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Rosacea and the Microbiome: A Systematic Review.

Dermatol Ther (Heidelb) 2021 Feb 10;11(1):1-12. Epub 2020 Nov 10.

Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, FL, USA.

Rosacea, a chronic inflammatory skin disease characterized by recurrent episodes of facial flushing, erythema, pustules, and telangiectasia, largely affects fair-skinned women over 30 years of age. Although a long-recognized entity, the exact pathophysiology of this disease is still debated. Current theories highlight the role of the cutaneous microbiome and its associated inflammatory effects in rosacea's pathogenesis. Read More

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February 2021