4,819 results match your criteria Bacterial Mouth Infections


Effects of a Chimeric Lysin against Planktonic and Sessile Hint at Potential Application in Endodontic Therapy.

Viruses 2018 05 29;10(6). Epub 2018 May 29.

Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

is a commensal opportunistic pathogen found in the intestine, mouth, and vaginal tract of humans. As an invasive pathogen in the oral cavity, is one of the leading causes of periapical endodontic lesions. However, due to the strong biofilm-forming capacity and tolerance of to conventional antibiotics and treatments, limited therapeutic options are available. Read More

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Design and Efficacy of Nanogels Formulations for Intranasal Administration.

Molecules 2018 May 23;23(6). Epub 2018 May 23.

Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa.

Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease. Read More

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Association of oral Helicobacter pylori with gastric complications.

Life Sci 2018 Jul 12;205:125-130. Epub 2018 May 12.

Immunology and Infectious Diseases Research Laboratory, Department of Microbiology, University of Karachi, Karachi, Pakistan.

Aim: This study was aimed to identify the presence of Helicobacter pylori (H. pylori) genes in oral mucosa and find out their relationship between oral H. pylori infection and gastric complications. Read More

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Domestic water buffaloes: Access to surface water, disease prevalence and associated economic losses.

Prev Vet Med 2018 Jun 27;154:102-112. Epub 2018 Mar 27.

CEN, Centre for Earth System Research and Sustainability Institute for Geography, University of Hamburg Bundesstraße 5520146 Hamburg, Germany; Department of Space Sciences, Institute of Space Technology, Islamabad, 44000, Pakistan.

Given the shortage and non-availability of freshwater in Pakistan, wastewater is being used for bathing water buffaloes; however, this has a negative impact on animal welfare. Although there is a vast literature on indirect linkages between wastewater and animal productivity, studies focusing on the direct impacts of water buffaloes bathing in wastewater on animal productivity and economic losses are rare. Therefore, using 360 domestic water buffalo farms, this study examines the expenditure and production losses associated with bathing (in wastewater and freshwater) and non-bathing water buffaloes by employing partial budgeting and resource adjustment component techniques. Read More

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ON THE COMPLEXITY OF SHARK BITE WOUNDS: FROM ASSOCIATED BACTERIA TO TRAUMA MANAGEMENT AND WOUND REPAIR.

J Trauma Acute Care Surg 2018 Mar 22. Epub 2018 Mar 22.

Researcher, University of West Florida, Department of Mathematics and Statistics, Pensacola, FL, USA, Shark Behaviorist, Shark Research Institute, Global Shark Attack File, Princeton, NJ, USA.

The mouth of a shark is a breeding ground for a large variety of bacteria which can easily get transferred onto a human body in the event of a shark bite. Here, we review infections originating from shark oral bacterial flora, which originate from the microbiome of its prey, as well as from the surroundings where an incident takes place. We use the example of an incident which occurred in an aquarium involving a sandtiger shark, Carcharias taurus. Read More

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March 2018
1 Read

Focus on periodontal disease and development of endocarditis.

J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):143-147

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Infective endocarditis is a devastating disease with high morbidity and mortality. The link to oral bacteria has been known for many decades and has caused ongoing concern for dentists, patients and cardiologists. The microbiota of the mouth is extremely diverse and more than 700 bacterial species have been detected. Read More

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February 2018

Genomewide Identification of Essential Genes and Fitness Determinants of UA159.

mSphere 2018 Jan-Feb;3(1). Epub 2018 Feb 7.

Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA.

Transposon mutagenesis coupled with next-generation DNA sequencing (Tn-seq) is a powerful tool for discovering regions of the genome that are required for the survival of bacteria in different environments. We adapted this technique to the dental caries pathogen UA159 and identified 11% of the genome as essential, with many genes encoding products required for replication, translation, lipid metabolism, and cell wall biogenesis. Comparison of the essential genome of UA159 with those of selected other streptococci for which such information is available revealed several metabolic pathways and genes that are required in , but not in some spp. Read More

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February 2018

Establishment of mouse gingival junctional epithelial cell line using a bioengineered tooth system.

Biochem Biophys Res Commun 2018 02 8;497(1):167-172. Epub 2018 Feb 8.

Department of Periodontology, School of Dentistry, Showa University, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan. Electronic address:

Junctional epithelium (JE), one of the constituents of periodontal tissue, has several unique features to prevent bacterial infection. However, the molecular mechanisms of these cells remain to be completely elucidated because there has been no JE cell line to date. We have succeeded in isolating JE cells expressing green fluorescent protein (GFP) by using a bioengineered tooth technique in mice. Read More

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February 2018
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Bronchoalveolar lavage for diagnosis of tuberculosis infection in elephants.

Epidemiol Infect 2018 Mar 5;146(4):481-488. Epub 2018 Feb 5.

Department of Reproduction Management,Leibniz Institute for Zoo and Wildlife Research,Alfred-Kowalke-Straße 17,Berlin 10315,Germany.

Tuberculosis (TB) has been known to affect elephants for thousands of years. It was put into spotlight when few circus elephants were diagnosed carrying Mycobacterium (M.) tuberculosis. Read More

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March 2018
1 Read

Detection of Pathogen Exposure in African Buffalo Using Non-Specific Markers of Inflammation.

Front Immunol 2017 11;8:1944. Epub 2018 Jan 11.

Department of Integrative Biology, Oregon State University, Corvallis, OR, United States.

Detecting exposure to new or emerging pathogens is a critical challenge to protecting human, domestic animal, and wildlife health. Yet, current techniques to detect infections typically target known pathogens of humans or economically important animals. In the face of the current surge in infectious disease emergence, non-specific disease surveillance tools are urgently needed. Read More

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January 2018
6 Reads

Quantification of hygiene indicators and Salmonella in the tonsils, oral cavity and rectal content samples of pigs during slaughter.

Food Microbiol 2018 May 15;71:120-128. Epub 2017 Mar 15.

Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820, Merelbeke, Belgium.

The tonsils, oral cavity and faeces of 94 pigs at slaughter were sampled to assess the numbers of total aerobic bacteria, Enterobacteriaceae and Escherichia coli in the rectal content, tonsils and oral cavity of pigs at time of evisceration. Moreover, the prevalence, numbers and types of Salmonella spp. were determined. Read More

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May 2018
2 Reads

Application of Metagenomic Analyses in Dentistry as a Novel Strategy Enabling Complex Insight into Microbial Diversity of the Oral Cavity.

Pol J Microbiol 2017 Mar;66(1):9-15

Department of Dental Microbiology, Medical University of Warsaw, Poland; Department of Microbiology, Central Clinical Hospital in Warsaw, Poland.

The composition of the oral microbiome in healthy individuals is complex and dynamic, and depends on many factors, such as anatomical location in the oral cavity, diet, oral hygiene habits or host immune responses. It is estimated at present that worldwide about 2 billion people suffer from diseases of the oral cavity, mainly periodontal disease and dental caries. Importantly, the oral microflora involved in local infections may spread and cause systemic, even life-threatening infections. Read More

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March 2017
1 Read

Sialolith removal in the submandibular region using surgical diode laser: report of two cases and literature review.

Oral Maxillofac Surg 2018 Mar 22;22(1):105-111. Epub 2018 Jan 22.

Department of Oral and Maxillofacial Surgery, Pontificial Catholic University of Rio Grande do Sul, PUC/RS, Av. Ipiranga, n.6681, Building 6, Porto Alegre, Rio Grande do Sul, 91530-001, Brazil.

Purpose: Sialolithiasis is defined as the presence of one or more calcified structures within the duct of a major or minor salivary gland. It occurs as a result of deposition of calcium salts around an accumulation of organic debris in the duct lumen. The main signs and symptoms are edema and bacterial infection with abscess formation. Read More

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March 2018
1 Read

Is the routine practice of antibiotic prescription and microbial culture and antibiotic sensitivity testing justified in primary maxillofacial space infection patients? A prospective, randomized clinical study.

J Craniomaxillofac Surg 2018 Mar 20;46(3):446-452. Epub 2017 Dec 20.

Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, MAMC Complex, Bahadur Shah Zafar Marg, New Delhi, 110002, India. Electronic address:

Purpose: The purpose of this prospective, randomized, comparative clinical study was to compare treatment outcome of removal of foci and incision and drainage, with or without oral antibiotic therapy, in the management of single primary maxillofacial space infection with a known focus.

Materials And Methods: A total of 40 patients with single primary maxillofacial space infection with a known infectious focus were divided into two groups, one treated with incision and drainage only, and the other with incision and drainage along with oral antibiotics. The focus of infection was addressed in both groups. Read More

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March 2018
3 Reads

Prevention of surgical site infection after oral cancer surgery by topical tetracycline: Results of a multicenter randomized control trial.

Medicine (Baltimore) 2017 Dec;96(48):e8891

Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki.

Background: In a pilot study, we showed that topical administration of a tetracycline could decrease oral bacteria levels for 6 hours in patients who underwent oral cancer surgery combined with tracheotomy and flap reconstruction. This multicenter, randomized control trial aimed to investigate the effectiveness of topical application of tetracycline ointment for prevention of surgical site infection (SSI) associated with major oral cancer surgery.

Methods: One hundred seventeen patients who underwent oral cancer resection combined with neck dissection, flap reconstruction, and tracheotomy were divided randomly into an intervention group (n = 56) and a control group (n = 61). Read More

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December 2017
3 Reads

Frequency and levels of candidate endodontic pathogens in acute apical abscesses as compared to asymptomatic apical periodontitis.

PLoS One 2018 2;13(1):e0190469. Epub 2018 Jan 2.

Department of Endodontics and Molecular Microbiology Laboratory, Estácio de Sá University, Rio de Janeiro, RJ, Brazil.

Introduction: Acute apical abscess is caused by bacteria that leave the infected dental root canal to invade the periodontal tissues. Most species occurring in abscesses are also found in asymptomatic infections; therefore, the possibility exists that not only the presence of certain species but also their specific counts influence the appearance of symptoms. This molecular study compared the frequency and levels of several candidate endodontic pathogens in teeth with acute apical abscesses and asymptomatic apical periodontitis. Read More

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February 2018
15 Reads

Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis.

Cochrane Database Syst Rev 2018 01 1;1:CD009376. Epub 2018 Jan 1.

Adult Comprehensive Dentistry, Dental School, University of Barcelona, Feixa LLarga s/n, Hospitalet de Llobregat, Barcelona, Spain, 08907.

Background: Periodontitis is a bacterially-induced, chronic inflammatory disease that destroys the connective tissues and bone that support teeth. Active periodontal treatment aims to reduce the inflammatory response, primarily through eradication of bacterial deposits. Following completion of treatment and arrest of inflammation, supportive periodontal therapy (SPT) is employed to reduce the probability of re-infection and progression of the disease; to maintain teeth without pain, excessive mobility or persistent infection in the long term, and to prevent related oral diseases. Read More

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January 2018
6 Reads

Culture-dependent approaches to explore the prevalence of root canal pathogens from endodontic infections.

Braz Oral Res 2017 Dec 18;31:e108. Epub 2017 Dec 18.

Tehran University of Medical Sciences, Department of Microbiology, School of Medicine, Tehran, Iran.

Endodontic infections are considered to be caused by the presence of various microorganisms within the root canal system. Recognition of this microbiota contributes to the successful treatment of infected root canals. This study investigated the microorganisms associated with primary and secondary endodontic infections via culture methods, biochemical tests, and molecular approaches in an Iranian population. Read More

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December 2017
9 Reads

Foot-and-mouth disease virus infection stimulates innate immune signaling in the mouse macrophage RAW 264.7 cells.

Can J Microbiol 2018 Feb 18;64(2):155-166. Epub 2017 Dec 18.

a College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070 Gansu, People's Republic of China.

The innate immune system acts as the first line of defense against invasion by bacterial and viral pathogens. The role of macrophages in innate immune responses to foot-and-mouth disease virus (FMDV) is poorly understood. To determine the mechanism underlying activation of innate immunity after FMDV infection in macrophages, we performed FMDV infection in mouse macrophage RAW 264. Read More

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February 2018
3 Reads

Elizabethkingia miricola as an opportunistic oral pathogen associated with superinfectious complications in humoral immunodeficiency: a case report.

BMC Infect Dis 2017 12 12;17(1):763. Epub 2017 Dec 12.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.

Background: Elizabethkingia miricola is a rare Gram-negative bacterium found in water and clinical specimens. Typical culturing methods often misidentify Elizabethkingia spp. as Flavobacterium or Chryseobacterium. Read More

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December 2017
5 Reads

Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial.

J Appl Oral Sci 2017 Nov-Dec;25(6):586-595

Universidade de Taubaté, Departamento de Odontologia, Núcleo de Pesquisa Periodontal, Taubaté, SP, Brasil.

Objective: Single dose of systemic antibiotics and short-term use of mouthwashes reduce bacteremia. However, the effects of a single dose of preprocedural rinse are still controversial. This study evaluated, in periodontally diseased patients, the effects of a pre-procedural mouth rinse on induced bacteremia. Read More

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February 2018
1 Read

[Actinomycosis revealed by ulceration of the palate and gingiva].

Ann Dermatol Venereol 2018 Mar 28;145(3):173-177. Epub 2017 Nov 28.

Service de dermatologie, CHU d'Amiens, 1, place Victor-Pauchet, 80000 Amiens, France; Université de Picardie-Jules-Verne, 80000 Amiens, France.

Background: Actinomycosis is a chronic and extensive granulomatous, bacterial infection. Revelation by oral ulceration is rare.

Patients And Methods: A 76-year-old patient with diabetes was treated with dabrafenib for stage IV melanoma. Read More

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March 2018
2 Reads

Transcriptome profiling analysis of senescent gingival fibroblasts in response to Fusobacterium nucleatum infection.

PLoS One 2017 30;12(11):e0188755. Epub 2017 Nov 30.

Department of Oral Biochemistry, Dental Science Research Institute, Medical Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea.

Periodontal disease is caused by dental plaque biofilms. Fusobacterium nucleatum is an important periodontal pathogen involved in the development of bacterial complexity in dental plaque biofilms. Human gingival fibroblasts (GFs) act as the first line of defense against oral microorganisms and locally orchestrate immune responses by triggering the production of reactive oxygen species and pro-inflammatory cytokines (IL-6 and IL-8). Read More

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December 2017
79 Reads

Age-related differences in the respiratory microbiota of chickens.

PLoS One 2017 22;12(11):e0188455. Epub 2017 Nov 22.

Infection and Immunity, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Midlothian, United Kingdom.

In this era of next generation sequencing technologies it is now possible to characterise the chicken respiratory microbiota without the biases inherent to traditional culturing techniques. However, little research has been performed in this area. In this study we characterise and compare buccal, nasal and lung microbiota samples from chickens in three different age groups using 16S rRNA gene analysis. Read More

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December 2017
1 Read

Potential Role of the Lung Microbiome in Shaping Asthma Phenotypes.

Authors:
Kian Fan Chung

Ann Am Thorac Soc 2017 Nov;14(Supplement_5):S326-S331

1 National Heart and Lung Institute, Imperial College London, London, United Kingdom; and.

The introduction of 16s ribosomal RNA sequencing as a nonculture technique has led to the discovery of the presence of microbiota in the lower airways of healthy individuals. These bacterial communities may originate from the mouth and nasopharynx or from the environment by inhalation. The microbial composition of the lower airways may be modulated by dietary factors, antibiotic therapy, and microbial infections, particularly in early life. Read More

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November 2017
3 Reads

Characteristic Comparison of Meningitis and Non-meningitis of Streptococcus suis in an Experimentally Infected Porcine Model.

Inflammation 2018 Mar;41(2):368-377

College of Veterinary Medicine, Jilin University, Xi'an Road 5333, Changchun, 130062, People's Republic of China.

This study tested the differences of meningitis and non-meningitis of Streptococcus suis (SS). In this study, an infected pig model of streptococcal meningitis was established. Compared with the non-meningitis Streptococcus suis group (JZLQ001 group), the meningitis Streptococcus suis group (JZLQ022) exhibited neurological symptoms, such as ataxia and foaming at the mouth, and the brain showed a large area of congestion at 5 days post-infection (p. Read More

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March 2018
4 Reads

Influence of Oral Anaerobic Bacteria on Hematopoietic Stem Cell Transplantation Patients: Oral Mucositis and General Condition.

Transplant Proc 2017 Nov;49(9):2176-2182

Department of Special Needs Dentistry, Division of Hygiene and Oral Health, Showa University School of Dentistry, Tokyo, Japan.

Objective: Oral mucositis (OM) caused by infection facilitated by myelosuppression and immunosuppression can be controlled through oral care. We investigated changes in oral anaerobic bacterial flora during the onset of OM with hematopoietic stem cell transplantation (HSCT).

Methods: This study included 19 patients who underwent HSCT. Read More

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November 2017
2 Reads

Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2.

Infect Immun 2018 01 19;86(1). Epub 2017 Dec 19.

Department of Pediatric Dentistry, School of Dentistry, The University of Alabama at Birmingham, Birmingham, Alabama, USA

is an indigenous oral spirochete that inhabits the gingival sulcus or periodontal pocket. Increased numbers of oral treponemes within this environment are associated with localized periodontal inflammation, and they are also part of an anaerobic polymicrobial consortium responsible for endodontic infections. Previous studies have indicated that stimulates the innate immune system through Toll-like receptor 2 (TLR2); however, the pathogen-associated molecular patterns (PAMPs) responsible for activation of the innate immune system are currently not well defined. Read More

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January 2018
3 Reads

Type-III secretion pore formed by flagellar protein FliP.

Mol Microbiol 2018 Jan 28;107(1):94-103. Epub 2017 Nov 28.

Department of Biology, University of Utah, Salt Lake City, UT, 84112, USA.

During assembly of the bacterial flagellum, protein subunits that form the exterior structures are exported through a specialized secretion apparatus energized by the proton gradient. This category of protein transport, together with the similar process that occurs in the injectisomes of gram-negative pathogens, is termed type-III secretion. The membrane-embedded part of the flagellar export apparatus contains five essential proteins: FlhA, FlhB, FliP, FliQ and FliR. Read More

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January 2018
5 Reads

Impact of oral antibiotics on health-related quality of life after mandibular third molar surgery: An observational study.

Niger J Clin Pract 2017 Sep;20(9):1189-1194

Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.

Aim: To compare the impact of antibiotics on health-related quality of life (QoL) outcomes following third molar surgery.

Materials And Methods: The study population consisted of 135 subjects that required surgical extraction of mandibular third molar under local anesthesia and met the inclusion criteria. The subjects were randomized into three study groups of 45 subjects each: Group A - extended amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England), 1 gram pre-operatively and then 625 mg BD for 5 days Group B - prophylactic amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England) 1 gram pre-operatively only, and Group C - prophylactic levofloxacin 1 gram pre-operatively only. Read More

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September 2017
1 Read

Bacterium 'Lasso' From Mouth to Heart Can Cause Disease.

Authors:

J Calif Dent Assoc 2017 04;45(4):175

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April 2017
1 Read

The Management of Infections and the Use of Antibiotic Prophylaxis by Dentists: A Review of the Evidence.

Authors:
George Maranon

J Calif Dent Assoc 2017 03;45(3):123-32

Dentistry plays an important role in managing the antibiotic resistance problem. Guidelines for the use of antibiotics for prevention of endocarditis, prosthetic joint infections and other medical conditions have changed frequently. Unfortunately, the original guidelines and subsequent changes were often made through consensus opinions and not evidence based. Read More

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March 2017
1 Read

Dental Implant Coatings Help Prevent Infection.

Authors:

J Calif Dent Assoc 2017 03;45(3):121

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March 2017
1 Read

Layer chicken embryo survival to hatch when administered an in ovo vaccination of strain F Mycoplasma gallisepticum and locations of bacteria prevalence in the newly hatched chick.

Poult Sci 2017 Sep;96(11):3879-3884

Poultry Science Department, Mississippi State University, Mississippi State, MS.

Mycoplasma gallisepticum (MG) is a bacterial pathogen that causes production losses in layer chickens. To combat MG, multiage layer facilities vaccinate pullets by either spray or eye-drop vaccination. The objective in this study was to evaluate the use of in ovo vaccination as a potential alternative for MG vaccination. Read More

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September 2017

Case report: Features of hand, foot and mouth disease in neonates.

Medicine (Baltimore) 2017 Oct;96(42):e8307

aDepartment of Neonatology bInternal Medicine Intensive Care Unit, Zhangzhou Municipal Hospital affiliated to Fujian Medical School, Zhangzhou, China.

Rationale: Hand, foot and mouth disease (HFMD) is caused by enterovirus. The virus may exist in secretions.

Patient Concerns: Five neonates had symptoms of fever and maculopapular rashes involving face, trunk, breech, arms, and legs, especially scattering on palms and feet. Read More

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October 2017
2 Reads

Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion.

PLoS One 2017 12;12(10):e0184438. Epub 2017 Oct 12.

Department of Dermatology, University Hospital Tübingen, Germany.

Candida albicans is an inhabitant of mucosal surfaces in healthy individuals but also the most common cause of fungal nosocomial blood stream infections, associated with high morbidity and mortality. As such life-threatening infections often disseminate from superficial mucosal infections we aimed to study the use of probiotic Lactobacillus rhamnosus GG (LGG) in prevention of mucosal C. albicans infections. Read More

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October 2017
13 Reads

KR-12-a5 is a non-cytotoxic agent with potent antimicrobial effects against oral pathogens.

Biofouling 2017 11 12;33(10):807-818. Epub 2017 Oct 12.

b São Paulo State University (UNESP), Department of Pediatric Dentistry and Public Health, School of Dentistry , Araçatuba , Brazil.

This study evaluated the cytotoxicity and antimicrobial activity of analogs of cationic peptides against microorganisms associated with endodontic infections. L-929 fibroblasts were exposed to LL-37, KR-12-a5 and hBD-3-1C and chlorhexidine (CHX, control), and cell metabolism was evaluated with MTT. The minimal inhibitory concentration (MIC) and the minimal bactericidal/fungicidal concentration (MBC/MFC) of the peptides and CHX were determined against oral pathogens associated with endodontic infections. Read More

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November 2017

Straight from the Horse's "Mouth": Genomic Epidemiology of an Icelandic Equine Epidemic.

Authors:
Mark R Davies

MBio 2017 Oct 10;8(5). Epub 2017 Oct 10.

Department of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

Despite tight biosecurity measures, an outbreak of respiratory disease rapidly spread across the Icelandic equine population in 2010. Horse transportation was brought to a halt in order to contain the spread of the infectious agent. In a recent article, Björnsdóttir and colleagues (S. Read More

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October 2017
15 Reads

Oral manifestations of inflammatory bowel disease.

J Biol Regul Homeost Agents 2017 Jul-Sep;31(3):817-821

Department of Experimental Biomedicine and Clinical Neuroscience, Section of Histology, (BIONEC), University of Palermo, Italy

Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, have important extraintestinal manifestations, notably in the oral cavity. These oral manifestations can constitute important clinical clues in the diagnosis and management of IBD, and include changes at the immune and bacterial levels. Aphthous ulcers, pyostomatitis vegetans, cobblestoning and gingivitis are important oral findings frequently observed in IBD patients. Read More

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December 2017
1 Read

The synthetic human beta-defensin-3 C15 peptide exhibits antimicrobial activity against Streptococcus mutans, both alone and in combination with dental disinfectants.

J Microbiol 2017 Oct 28;55(10):830-836. Epub 2017 Sep 28.

Department of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University, Seoul, 08826, Republic of Korea.

Streptococcus mutans is a major etiologic agent of human dental caries that forms biofilms on hard tissues in the human oral cavity, such as tooth and dentinal surfaces. Human β-defensin-3 (HBD3) is a 45-amino-acid natural antimicrobial peptide that has broad spectrum antimicrobial activity against bacteria and fungi. A synthetic peptide consisting of the C-terminal 15 amino acids of HBD3 (HBD3-C15) was recently shown to be sufficient for its antimicrobial activity. Read More

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October 2017
2 Reads

Lamina propria group 2 innate lymphoid cells impair the antibacterial defense of burned mice to enterococcal translocation.

J Leukoc Biol 2017 Dec 26;102(6):1451-1460. Epub 2017 Sep 26.

Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, USA;

Gut microbiota that invades to the defective mucosal barrier is one of the major sources of infectious complications in severely burned hosts. In this study, a role of group 2 innate lymphoid cells (ILC2) and effects of -{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-2-thiophenesulfonamide (SR3335) on the host antibacterial resistance against infectious complications caused by oral infection were investigated in burned mice. Retinoic acid receptor-related orphan receptor α (RORα) is a transcription factor required for the development of ILC2, and SR3335 is an RORα-selective inverse agonist. Read More

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December 2017
6 Reads

Gut biofilm forming bacteria in inflammatory bowel disease.

Microb Pathog 2017 Nov 20;112:5-14. Epub 2017 Sep 20.

Department of Biotechnology, National Institute of Technology, Raipur 492010, Chhattisgarh, India. Electronic address:

Inflammatory bowel disease (IBD) symbolizes a group of intestinal disorders in which prolonged inflammation occur in the digestive tract (esophagus, large intestine, small intestine mouth, stomach). Both genetic and environmental factors (infections, stress, diet) are involved in the development of IBD. As we know that bacteria are found in the intestinal mucosa of human and clinical observations revealed bacterial biofilms associated with patients of IBD. Read More

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November 2017
6 Reads

[Real world analysis to explore Xiyanping injection combined with other drugs for hand-foot-mouth disease].

Zhongguo Zhong Yao Za Zhi 2016 Dec;41(24):4510-4515

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Integrated network analysis was used in this paper to analyze Xiyanping injection combined therapy for hand-foot-mouth disease based on the registered research data of 3 204 cases. It was found that the drug combination therapy was almost consistent with the guidelines for the diagnosis and treatment of hand foot mouth disease, but there were some problems to be noticed: there were too many applications of antibiotics, more than the need in preventing secondary infection; and ribavirin was not necessary for use. This article showed that the clinical antibacterial and antiviral values of Xiyanping injection has not been well recognized for hand-foot-mouth disease. Read More

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December 2016
4 Reads

[Targeting the skin - erythema multiforme in dogs and cats].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2017 Oct 20;45(5):352-356. Epub 2017 Sep 20.

Teresa Böhm, Medizinische Kleintierklinik, Ludwig-Maximilians-Universität München, Veterinärstraße 13, 80539 München, E-Mail:

This review article will describe the complex nature of erythema multiforme in dogs and cats. The disease pattern will be illustrated in terms of etiology, pathogenesis, clinical signs, diagnostics and therapy. Erythema multiforme is a rare, immune-mediated skin disorder with an acute specific reaction pattern of skin and mucous membranes against different underlying causes. Read More

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October 2017
8 Reads

Face Masks and Cough Etiquette Reduce the Cough Aerosol Concentration of Pseudomonas aeruginosa in People with Cystic Fibrosis.

Am J Respir Crit Care Med 2018 Feb;197(3):348-355

1 Lung Bacteria Group and.

Rationale: People with cystic fibrosis (CF) generate Pseudomonas aeruginosa in droplet nuclei during coughing. The use of surgical masks has been recommended in healthcare settings to minimize pathogen transmission between patients with CF.

Objectives: To determine if face masks and cough etiquette reduce viable P. Read More

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February 2018
13 Reads

[Acute skin infections and their imitators in children : A photo quiz].

Hautarzt 2017 Oct;68(10):774-783

Abteilung pädiatrische Dermatologie, Universitäts-Kinderspital Zürich, Steinwiesstrasse 75, 8032, Zürich, Schweiz.

Background: Skin infections account for 40% of emergency visits in pediatric dermatology. It is important to promptly recognize skin infections with potential complications and initiate treatment. However some characteristic skin findings may imitate skin infections and are often misdiagnosed. Read More

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October 2017
4 Reads

Euflammation Attenuates Central and Peripheral Inflammation and Cognitive Consequences of an Immune Challenge after Tumor Development.

Neuroimmunomodulation 2017 13;24(2):74-86. Epub 2017 Sep 13.

Institute for Behavioral Medicine Research, Ohio State University Wexner Medical Center, Columbus, OH, USA.

Objective: Repeated subthreshold bacterial exposures in rodents cause novel euflammation that attenuates neuroinflammation and sickness behaviors upon subsequent infectious challenges to the host without eliciting illness behavior. The investigation of bacterial exposure effects on brain and behavior is clinically relevant because bacterial-based antitumor treatments are used successfully, but are suboptimal due to their illness side effects. In addition, behavioral consequences (depression, cognitive impairments) to homeostatic challenges that are associated with inflammation are prevalent and reduce the quality of life in cancer patients and survivors. Read More

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June 2018
3 Reads

Occurrence of vancomycin-resistant Staphylococcus aureus in the oral cavity of patients with dental caries.

Acta Microbiol Immunol Hung 2017 Sep 11;64(3):343-351. Epub 2017 Sep 11.

6 Visiting Professor, College of Applied Medical Sciences, King Saud University , Riyadh, Saudi Arabia.

Oral streptococci are the major group of microbes isolated from oral microflora. They represent frequent pathogens of infective endocarditis (IE), and it is assumed that in most of the cases oral streptococci are acquired via mucosa layer of oral cavity. Staphylococcus aureus is also frequently isolated from IE as it accounts for 20%-30% of all cases. Read More

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September 2017
6 Reads

Probing the potential of mucus permeability to signify preterm birth risk.

Sci Rep 2017 Sep 4;7(1):10302. Epub 2017 Sep 4.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Preterm birth is the leading cause of neonatal mortality, and is frequently associated with intra-amniotic infection hypothesized to arise from bacterial ascension across a dysfunctional cervical mucus plug. To study this dysfunction, we assessed the permeability of cervical mucus from non-pregnant ovulating (n = 20) and high- (n = 9) and low-risk (n = 16) pregnant women to probes of varying sizes and surface chemistries. We found that the motion of negatively charged, carboxylated microspheres in mucus from pregnant patients was significantly restricted compared to ovulating patients, but not significantly different between high- and low-risk pregnant women. Read More

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September 2017
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Enhancing antibacterial effect of sodium hypochlorite by low electric current-assisted sonic agitation.

PLoS One 2017 30;12(8):e0183895. Epub 2017 Aug 30.

Department of Electronics and Communication, Faculty of Engineering & Architect, Süleyman Demirel University, Isparta, Turkey.

Background: This research focused on the effects of low electric current (μE)-assisted sonic agitation of sodium hypochlorite on Enterococcus faecalis infected human root dentin.

Methods: Extracted human canine roots were instrumented, sterilized, and experimentally contaminated with E. faecalis. Read More

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October 2017
4 Reads