Search Our Scientific Publications & Authors

Biosens Bioelectron 2019 Mar 22;129:198-207. Epub 2019 Jan 22.

University Hospital Tübingen, Section Medical Materials Science & Technology, Osianderstr. 2-8, D-72076 Tübingen, Germany. Electronic address:

Bacteria adhering to implanted medical devices can cause invasive microbial infections, of e.g. skin, lung or blood. Read More

Clin Pract 2018 Oct 4;8(4):1102. Epub 2018 Dec 4.

Department of Dermatology, King Fahad Central Hospital, Jazan, Saudi Arabia.

Actinomycosis is a subacute or chronic suppurative bacterial infection which caused because of filamentous gram-positive, anaerobic to microaerophilic nonacid fast bacilli primarily of the genus that normally colonize the mouth, colon, and vagina. Primary cutaneous actinomycosis is a rare entity and is generally associated with trauma. A 61- year-old Yemeni male firstly presented to the surgical department in King Fahd Central Hospital with multiple swelling, petted lesions and boring of sensation in the right foot. Read More

Rev Chil Pediatr 2018 Oct;89(5):644-649

Unidad ECMO, Clínica Las Condes, Chile.

Introduction: Endocarditis is a rare disease in children, especially in those without previous heart disease, and Kingella Kingae (KK) is rarely identified as the cause. Extracorporeal membrane oxyge nation (ECMO) is a support for both heart and respiratory failure.

Objective: To report the first case of infectious endocarditis (IE) due to KK which required ECMO support secondary to refractory cardiogenic shock. Read More

Int J Gen Med 2018 28;11:451-456. Epub 2018 Nov 28.

Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK,

Purpose: Pharyngitis is commonly caused by a self-limiting upper respiratory tract infection (URTI) and symptoms typically include sore throat. Antibiotics are often inappropriately used for the treatment of pharyngitis, which can contribute to antimicrobial resistance, therefore non-antibiotic treatments which have broad antiseptic effects may be more appropriate. Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) are present in some antiseptic lozenges and have established benefits in providing symptomatic relief and some in vitro antiviral action. Read More

J Microbiol 2019 Jan 2;57(1):64-73. Epub 2018 Oct 2.

Radiation Biotechnology Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea.

Salmonella enterica is a major human pathogen that causes invasive non-typhoidal Salmonellosis (iNTS), resulting in significant morbidity and mortality. Although a number of pre-clinical and clinical studies have reported on the feasibility of developing a safe and effective vaccine against iNTS, there have been no licensed Salmonella vaccines available to protect against NTS strains. Vaccine formulations of highest priority for NTS are live attenuated vaccines, which can elicit effective induction of intestinal mucosal and intracellular bacteria-specific cell mediated immune responses. Read More

Braz Oral Res 2018 Nov 29;32:e120. Epub 2018 Nov 29.

Universidade Federal de Minas Gerais - UFMG, Faculty of Dentistry, Department of Restorative Dentistry, Belo Horizonte, MG, Brazil.

The present study aims to evaluate the longitudinal effects of induced experimental infections in gnotoxenic animals on the expression of inflammatory chemokines and their receptors in periradicular tissues. The null hypothesis tested was that Enterococcus faecalis and Fusobacterium nucleatum had no effect on CCR5, CCL5, CXCL10, CCL2/MCP-1, CXCR2 and CCR1 expression. Two groups of five animals (n = 5) aged between 8 and 12 weeks were used in this study. Read More

Rev Assoc Med Bras (1992) 2018 Oct;64(10):928-935

Universidad de Concepción, Víctor Lamas 1290, casilla 160 C, Concepción, Región del Biobío, Chile.

Background: There is evidence of detection of Helicobacter pylori (H. pylori) in the stool of newborns and in the yeast that colonizes the oral cavity of this age group. However, there is a lack of research to confirm it. Read More

J Innate Immun 2018 Nov 28:1-12. Epub 2018 Nov 28.

Swedish Dental Service of Skåne, Lund,

Antimicrobial peptides (AMPs) are a diverse family of peptides that defend the mucosal surfaces of the oral cavity and other locations. Many AMPs have multiple functions and properties that influence aspects of innate defense and colonization by microorganisms. The human oral cavity is home to the second-most diverse microbiome, and the health of the mouth is influenced by the presence of these bacteria as well as by extrinsic factors such as periodontitis and smoking. Read More

Emerg Med Clin North Am 2019 Feb;37(1):69-80

Department of Emergency Medicine, Northwestern University, 211 East Ontario - Suite 300, Chicago, IL 60611, USA. Electronic address:

This article reviews the presentation, diagnosis, and management of common and "can't miss" infections of the oropharynx, including streptococcal pharyngitis, infectious mononucleosis, peritonsillar abscess, retropharyngeal abscess, and epiglottitis. Read More

Cell Mol Biol (Noisy-le-grand) 2018 Oct 30;64(13):1-5. Epub 2018 Oct 30.

Immunology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Enterococcus faecalis is an important opportunistic infectious agent involving the oral cavity and endodontics. The aim of this study was to evaluate the expression ratio of efaA gene in biofilm producer E. faecalis before and after receiving acidic and alkali shocks. Read More

PLoS One 2018 5;13(11):e0207016. Epub 2018 Nov 5.

Department of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.

Objective: We investigated the association between bacterial microbiota in breast milk and the infant mouth. The influence of human papilloma virus (HPV) infection on infant oral microbiota was also assessed.

Material And Methods: Altogether 35 breast milk and 35 infant oral samples with known HPV status were selected from the Finnish Family HPV Study cohort. Read More

Int J Biol Macromol 2019 Feb 25;122:224-227. Epub 2018 Oct 25.

Graduate School of Medicine, Wakayama Medical University, Wakayama 641-0011, Wakayama, Japan.

We have tested here whether or not arginine, a well-known aggregation suppressor, is effective in removing bacterial cells, which may present a potential risk of accidental pneumonia infection in aged individuals, from the oral mucosal membranes. This is based on the ability of arginine to suppress protein-protein interaction and surface adsorption and increase the solubility of organic compounds. Twelve student volunteers were subjected to mouthwashes with saline, citrate buffer (pH 3. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Oct;53(10):681-687

Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

To evaluate the antimicrobial activity of nonequilibrium plasma against (Ef) biofilms and to obtain novel evidence of root canal disinfection with nonequilibrium plasma. Sterile cover slips and single-rooted canals were filled with Ef and incubated to form 1-week-old and 3-week-old biofilms, respectively. The infected samples were subjected to nonequilibrium plasma, 2% chlorhexidine digluconate (CHX) and saline for 3, 10 and 30 minutes, respectively. Read More

J Invasive Cardiol 2018 Nov;30(11):416-420

UC San Diego Sulpizio Cardiovascular Center, 9434 Medical Center Drive #7844, La Jolla, CA 92037 USA.

Objectives: Quantify and characterize bacterial contamination of lead aprons in a high-volume catheterization laboratory and evaluate the efficacy of decontamination using an ultraviolet-C (UV-C) radiation system.

Background: Bacterial contamination and ineffective disinfection of personal protective equipment in medical centers pose potential health risks to patients and medical staff. The contamination burden of lead aprons and a reliable disinfection strategy are unknown. Read More

Braz Oral Res 2018 Oct 18;32(suppl 1):e69. Epub 2018 Oct 18.

Universidade Estadual de Campinas -Unicamp, Piracicaba Dental School, Department of Restorative Dentistry, Piracicaba, SP, Brazil.

Evidence shows the polymicrobial etiology of endodontic infections, in which bacteria and their products are the main agents for the development, progression, and dissemination of apical periodontitis. Microbial factors in necrotic root canals (e.g. Read More

Braz Oral Res 2018 Oct 18;32(suppl 1):e65. Epub 2018 Oct 18.

Private practice, Cetraro, Italy.

Chemomechanical preparation is intended to clean, disinfect, and shape the root canal. This step is of utmost importance during treatment of infected teeth with apical periodontitis, because treatment outcome depends on how effectively the clinician eliminates bacteria, their products, and necrotic tissue that would serve as substrate for bacterial regrowth. Nonetheless, curvatures and complex internal anatomical variations of the root canal system can pose a high degree of difficulty in reaching these goals. Read More

NPJ Biofilms Microbiomes 2018 10;4:23. Epub 2018 Oct 10.

1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA.

Mucus is a biological gel that lines all wet epithelia in the body, including the mouth, lungs, and digestive tract, and has evolved to protect the body from pathogenic infection. However, microbial pathogenesis is often studied in mucus-free environments that lack the geometric constraints and microbial interactions in physiological three-dimensional mucus gels. We developed fluid-flow and static test systems based on purified mucin polymers, the major gel-forming constituents of the mucus barrier, to understand how the mucus barrier influences bacterial virulence, particularly the integrity of biofilms, which can become resistant to immune clearance and antimicrobial agents. Read More

Arch Craniofac Surg 2018 Sep 20;19(3):222-226. Epub 2018 Sep 20.

Department of Plastic and Reconstructive Surgery, Myongji Hospital, Goyang, Korea.

A 70-year-old male with a history of diabetes mellitus, hypertension, and coronary stent insertion visited our hospital 7 days after biting his lower lip. Swelling and inflammation had worsened despite debridement and antibiotic treatment. On the 8th hospital day, fungal infection with Candida albicans and superimposed bacterial infection with Klebsiella pneumoniae were found on tissue culture. Read More

Proc Natl Acad Sci U S A 2018 10 2;115(42):10738-10743. Epub 2018 Oct 2.

The Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, M13 9PT Manchester, United Kingdom;

γδ T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how these cells contribute to homeostasis at the gingiva, a key oral barrier and site of the common chronic inflammatory disease periodontitis, has not been explored. Here we demonstrate that the gingiva is policed by γδ T cells with a T cell receptor (TCR) repertoire that diversifies during development. Read More

Int J Pharm 2018 Dec 29;552(1-2):206-216. Epub 2018 Sep 29.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, People's Republic of China. Electronic address:

Eliminating the infection from root canals and periodontal tissues of human teeth as well as the repair of infected periodontal bone has been a great challenge. Poly(lactide-co-glycolide) (PLGA) particles have been used for drug delivery due to their biodegradability, sustained drug release and nontoxic properties. As silver ions (Ag) exhibit strong antibacterial ability and calcium ions (Ca) are essential for hard tissue regeneration, the Ag and Ca were encapsulated into the PLGA particles to form AgCa-PLGA submicron particles. Read More

Front Immunol 2018 13;9:2003. Epub 2018 Sep 13.

Department of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.

Outer membrane porins, as the major components of Gram-negative bacterial membrane proteins, have been proven to be involved in interactions with the host immune system and potent protective antigen candidates against bacterial infection in fish. Outer membrane porin F (OmpF) is one of the major porins of (), the causative agent of enteric red mouth disease of salmonid and non-salmonid fish. In the present study, the molecular characterization and phylogenetic analysis of OmpF gene was studied, heterogenous expression, immunogenicity and protective immunity of OmpF were systemically evaluated as a subunit vaccine for channel catfish against infection. Read More

Int J Environ Res Public Health 2018 09 27;15(10). Epub 2018 Sep 27.

Intensive Care Unit, University Hospital of Martinique, Fort-de-France, 97200 Martinique, France.

In Martinique, snakebite, although relatively uncommon (~30 cases/year), may result in serious complications such as systemic thrombosis and local infections. Infections have been hypothesized to be related to bacteria present in the snake's oral cavity. In this investigation, we isolated, identified, and studied the susceptibility to beta-lactams of bacteria sampled from the oral cavity of twenty-six specimens collected from various areas in Martinique. Read More

Acta Clin Croat 2018 Mar;57(1):91-95

Department of ENT and Head and Neck Surgery, Vukovar General Hospital, Vukovar, Croatia.

Helicobacter (H.) pylori is the cause of one of the most common chronic bacterial infections in humans. Risk factors for the development of laryngeal cancer are cigarette smoke, alcohol, and human papillomavirus. Read More

Otolaryngol Pol 2018 Aug;72(4):42-50

Studenckie Koło Naukowe przy Klinice Otolaryngologii i Laryngologii Onkologicznej, Uniwersytet Medyczny w Łodzi.

Acute infections of the upper respiratory tract and upper gastrointestinal tract (mouth and throat) are still the most common reason for reporting to the general practitioner or ENT specialist. Despite the fact that the most common causative agent of these diseases is a virus, antibiotics are still flavored in about 60-80% of patients who report to the doctor. In consensuses such as EPOS, WHO reports and other local/ / national reports, there is a need to limit antibacterial treatment for and to replace it with symptomatic and anti-inflammatory drugs. Read More

Nat Commun 2018 09 13;9(1):3713. Epub 2018 Sep 13.

Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, China.

The use of natural substance to ward off microbial infections has a long history. However, the large-scale production of natural extracts often reduces antibacterial potency, thus limiting practical applications. Here we present a strategy for converting natural organosulfur compounds into nano-iron sulfides that exhibit enhanced antibacterial activity. Read More

Cell Physiol Biochem 2018 5;49(3):884-898. Epub 2018 Sep 5.

College of Basic Medical Sciences, Dalian Medical University, Dalian, China.

Background/aims: Periapical periodontitis is caused by bacterial infection and results in both one destruction and tooth loss. Osteopontin (OPN) is a secreted phosphorylated glycoprotein that participates in bone metabolism.

Methods: Thirty-three patients with chronic periapical periodontitis and 10 patients who had undergone the orthodontic removal of healthy tooth tissue (control) at the periodontal ligament were investigated, and an animal model of mouse periapical periodontitis was established for an in vivo analysis. Read More

J Endod 2018 Oct 31;44(10):1583-1592. Epub 2018 Aug 31.

Department of Endodontics, Faculty of Dentistry, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil; Post-Graduate Program in Dentistry, School of Dentistry, Federal University of Maranhão, São Luís, Maranhão, Brazil.

This article describes 2 unusual cases of mucosal fenestration associated with necrotic infected teeth, resulting in exposure of the root apex to the oral cavity. Both cases consisted of maxillary incisors with pulp necrosis and radiographic/tomographic evidence of apical periodontitis. Clinically, the root apex was exposed to the oral cavity through a fenestration in both bone and mucosa and covered with bacterial plaque and calculus. Read More

PLoS One 2018 28;13(8):e0202791. Epub 2018 Aug 28.

Department of Oral Microbiology, Division of Oral Infections and Health Sciences, Asahi University School of Dentistry, Hozumi, Mizuho, Gifu, Japan.

Porphyromonas gingivalis possesses various abilities to evade and disrupt host immune responses, by which it acts as an important periodontal pathogen. P. gingivalis produces outer membrane protein A (OmpA)-like proteins (OmpALPs), Pgm6 and Pgm7, as major O-linked glycoproteins, but their pathological roles in P. Read More

Int J Oral Maxillofac Surg 2019 Feb 23;48(2):263-273. Epub 2018 Aug 23.

Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China. Electronic address:

The objectives of this systematic review were to investigate the efficacy of amoxicillin/amoxicillin-clavulanic acid for reducing the risk of postoperative infection after third molar surgery and to evaluate the adverse outcomes in these patients, as well as in healthy volunteers. A systematic search of four databases was performed on May 26, 2017. Eleven studies qualified for the qualitative analysis and eight were found suitable for meta-analysis. Read More

Int J Mol Sci 2018 Aug 23;19(9). Epub 2018 Aug 23.

Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.

Periodontal disease, a chronic disease caused by bacterial infection, eventually progresses to severe inflammation and bone loss. Regulating excessive inflammation of inflamed periodontal tissues is critical in treating periodontal diseases. The periodontal ligament (PDL) is primarily a connective tissue attachment between the root and alveolar bone. Read More

J Microbiol 2018 Sep 23;56(9):673-682. Epub 2018 Aug 23.

Department of Medicine and Nutrition, Division of Health Sciences, Campus León, University of Guanajuato, Guanajuato, 37670, Mexico.

Obesity is a chronic disease associated with different metabolic diseases as well as alterations in immune cell function. It is characterized by a chronic systemic low grade inflammation. There are several studies demonstrating the influence of obesity on the impaired immune response to infection. Read More

ScientificWorldJournal 2018 4;2018:4757458. Epub 2018 Jul 4.

GI Microbiology and Biotechnology Unit, Agricultural Research Council, Animal Production Institute, Irene, Pretoria 0062, South Africa.

Oral and skin infections contribute significantly to the global health challenges responsible for the current trend of increased morbidity and premature death. The purpose of this study was to document medicinal plants used in the management of oral and skin infections in Ebem-Ohafia Local Government Area (LGA), Abia State, and to characterize the antioxidant and antibacterial activity. The thin layer chromatography (TLC) profiling of ten of the selected folklore medicine was carried out using a various solvent system of different polarity index. Read More

Microb Pathog 2018 Oct 8;123:473-477. Epub 2018 Aug 8.

Department of Endodontics and Periodontics, College of Stomatology, Dalian Medical University, Dalian, China. Electronic address:

Orthodontic treatments often include dental displacement using a fixed retainer such as braces, which may result in the accumulation of plaque that provides a suitable environment for microorganisms to cause oral infection. So, this study was designed to investigate the microbial diversity among orthodontic patients and healthy individuals.

Methods: Fifty individuals i. Read More

PLoS One 2018 9;13(8):e0201888. Epub 2018 Aug 9.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Periodontal disease is common in dogs and is initiated by gingival plaque composed of several hundred bacterial species. Some of these species have specifically been pointed out as potential periodontal pathogens, such as Treponema spp. Treponema spp. Read More

Photodiagnosis Photodyn Ther 2018 Sep 2;23:331-338. Epub 2018 Aug 2.

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Antimicrobial photodynamic therapy (aPDT) has emerged as one of the promising non-invasive adjuvant treatments of endodontic infections. The key part of this technique is application of an optimized nontoxic photosensitizer (PS), like indocyanine green (ICG) which when activated by light can destroy bacterial contaminants. Notwithstanding all featured properties of ICG, this PS mainly suffers from the lack of stability and concentration-dependent aggregation. Read More

Med Microbiol Immunol 2018 Nov 28;207(5-6):329-338. Epub 2018 Jul 28.

Oral Microbiology, Institute of Dentistry, Umeå University, Umeå, Sweden.

Phosphorylcholine (ChoP) is covalently incorporated into bacterial surface structures, contributing to host mimicry and promoting adhesion to surfaces. Our aims were to determine the frequency of ChoP display among Aggregatibacter actinomycetemcomitans strains, to clarify which surface structures bear ChoP, and whether ChoP-positivity relates to serum killing. The tested oral (N = 67) and blood isolates (N = 27) represented 6 serotypes. Read More

J Endod 2018 Aug;44(8):1308-1316

Department of Endodontics, Faculty of Dentistry, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil.

This article describes a case of large persistent posttreatment apical periodontitis associated with 2 maxillary incisors, which was successfully managed by periradicular surgery. Histobacteriologic analysis revealed that the lesion was a granuloma that contained in its body a very large actinomycoticlike colony surrounded by accumulations of polymorphonuclear leukocytes and showing no direct communication with the root canal systems from both teeth. One incisor had no evidence of persistent intraradicular infection, whereas the other exhibited some residual dentinal tubule infection in the apical canal, which may have not significantly contributed to persistent inflammation given the organization and agglomeration of inflammatory cells around the large extraradicular bacterial colony. Read More

J Orthop Translat 2018 Jul 27;14:57-62. Epub 2018 Jun 27.

Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People's Republic of China.

Background: Surgical masks (SMs) are used to reduce bacterial shedding from the mouth, nose and face. This study aimed to investigate whether SMs may be a potential source of bacterial shedding leading to an increased risk of surgical site infection.

Methods: Bacterial contamination of the SMs was tested by making an impression of the external surface of the mask on sterile culture media immediately. Read More

Microbiol Immunol 2018 Sep 4;62(9):554-566. Epub 2018 Sep 4.

Department of Microbiology and Oral Infection, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.

Prevotella melaninogenica is a gram-negative anaerobic commensal bacterium that resides in the human oral cavity and is isolated as a pathogen of suppurative diseases both inside and outside the mouth. However, little is known about the pathogenic factors of P. melaninogenica. Read More

Int J Oral Maxillofac Implants 2018 Jul/Aug;33(4):853-862

Purpose: The objective of this investigation was to assess the microbiologic contamination in the inner surface of titanium implants prior to prosthetic abutment placement.

Materials And Methods: The study population consisted of partially edentulous individuals who had previously received at least one internal hexagon titanium dental implant. A bacterial sample of the inner surface of the individual dental implant was taken after surgical reopening for healing abutment placement. Read More

Arch Oral Biol 2018 Oct 7;94:93-98. Epub 2018 Jul 7.

Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad, Telangana, 500007, India.

Objectives: Acinetobacter baumannii is an opportunistic pathogen which has recently been categorized as a high risk pathogen by World Health Organisation (WHO). The microbe has stealthily entered the oral cavity and has established itself as a potential pathogen by acquiring drug resistance and expression of several virulence genes. Surveillance on the type of virulence factors harboured by the organism will enable us to comprehend the mechanism of pathogenesis. Read More

Sci Rep 2018 Jul 16;8(1):10713. Epub 2018 Jul 16.

Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.

Enterovirus 71 (EV71) is an aetiological agent responsible for seasonal epidemics of hand-foot-and-mouth disease, which causes considerable mortality among young children. Mucosal vaccines can efficiently induce secretory IgA at mucosal surfaces and thereby prevent or limit infection at the site of virus entry. CpG oligodeoxynucleotides (ODNs), which resemble bacterial DNA, can induce the innate immune response through activation of Toll-like receptor 9. Read More

PLoS One 2018 11;13(7):e0200285. Epub 2018 Jul 11.

Infectious Diseases, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, United States of America.

Background: The effect of smoking on microbial dysbiosis and the potential consequence of such shift on markers of HIV disease is unknown. Here we assessed the relationship of microbial dysbiosis with smoking and markers of HIV disease.

Methods: Oral wash was collected from: (1) HIV-infected smokers (HIV-SM, n = 48), (2) HIV-infected non-smokers (HIV-NS, n = 24), or (3) HIV-uninfected smokers (UI-SM, n = 24). Read More

J Laryngol Otol 2018 Jul 10;132(7):611-614. Epub 2018 Jul 10.

Department of Otorhinolaryngology and Maxillofacial Surgery,Zealand University Hospital,Køge,Denmark.

Objective: Bacterial infection is a common finding in acute sialadenitis and may play a role in the chronicity of the condition. This study investigated if bacterial biofilm is present in submandibular chronic obstructive sialadenitis.

Methods: A descriptive case-control study was conducted that compared 10 histological sections of submandibular glands with chronic obstructive sialadenitis, to 10 histological sections of the healthy part of submandibular glands with pleomorphic adenoma. Read More

Int J Mol Sci 2018 Jul 6;19(7). Epub 2018 Jul 6.

Department of Prosthetic Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

Oral infections occur frequently in humans and often lead to chronic inflammations affecting the teeth (i.e., caries), the gingival tissues surrounding the teeth (i. Read More

Medicine (Baltimore) 2018 Jul;97(27):e11260

Lucian Blaga University of Sibiu, Faculty of Medicine Sibiu.

Rationale: Streptococcus viridans, a heterogeneous group of alpha-hemolytic streptococci, is part of the normal flora of the mouth, usually responsible for dental caries (Streptococcus mutans, Streptococcus sanguinis), and pericoronitis, as well as for subacute infective endocarditis. They are responsible for 40-60% of the endocarditis cases occurring on the normal valves, especially in male patients and over 45 years of age. A change in the bacterial flora of the oral cavity is taking part after orthodontic fixed appliances are introduced into the oral cavity, change that is associated with an increased concentration of the acidogenic bacteria. Read More

J Indian Soc Pedod Prev Dent 2018 Apr-Jun;36(2):191-197

Department of Pedodontics and Preventive Dentistry, Rishiraj College of Dental Sciences, Bhopal, Madhya Pradesh, India.

Objectives: To evaluate the aerobic and anaerobic antimicrobial efficacy of Ocimum Sanctum (Tulsi) essential oil and compare it with that of triple antibiotic paste (TAP) by collecting microbiological samples from the root canals of primary molars.

Study Design: Forty children were selected for the study and were randomly divided into two groups of twenty each, namely, TAP group and O. sanctum group (basil). Read More

Drug Deliv 2018 Nov;25(1):1504-1515

a Department of Otolaryngology and Ophtalmology , Prof. Stanislaw Popowski Voivoid Children Hospital Department of Head and Neck Surgery - Maxillofacial Surgery , Zołnierska , Olsztyn , Poland.

Along with the development of nanotechnological strategies for biomaterials associated with the prevention of infections, a myriad of clinically unproven techniques have been described to date. In this work, the aim was to perform a critical analysis of the literature available concerning antibacterial biomaterials for oral implantology and to provide a practical derivation for such a purpose. As anti-adhesive strategies may affect osseointegration, they should no longer be recommended for inclusion in this class of biomaterials, despite promising results in biomedical engineering for other, non-bone load bearing organs. Read More

Sci Rep 2018 Jun 28;8(1):9787. Epub 2018 Jun 28.

Department of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.

We investigated the association between HPV infection and bacterial microbiota composition in the placenta, uterine cervix and mouth in thirty-nine women. HPV DNA genotyping of 24 types was conducted using Multimetrix. Microbiota composition was characterized by 16S rRNA gene sequencing. Read More

PLoS One 2018 25;13(6):e0199676. Epub 2018 Jun 25.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

Periodontal disease is one of the most commonly diagnosed oral diseases in dogs and can result from undisturbed dental plaque. Dental prophylaxis is a routinely practiced veterinary procedure, but its effects on both the plaque and oral microbiota is not fully understood. The objectives of this study were to evaluate the impact of dental prophylaxis on the composition of the supragingival plaque and composite oral microbiota in clinically healthy dogs and to determine if composite sampling could be used in lieu of sampling the plaque microbiota directly. Read More