26,664 results match your criteria Bacterial Infections and Pregnancy


Iron deficiency anaemia: experiences and challenges.

Proc Nutr Soc 2018 Jul 10:1-8. Epub 2018 Jul 10.

Department of Pathology,University of Cambridge,Cambridge CB2 1QP,UK.

Iron deficiency remains the largest nutritional deficiency worldwide and the main cause of anaemia. Severe iron deficiency leads to anaemia known as iron deficiency anaemia (IDA), which affects a total of 1·24 billion people, the majority of whom are children and women from resource-poor countries. In sub-Saharan Africa, iron deficiency is frequently exacerbated by concomitant parasitic and bacterial infections and contributes to over 120 000 maternal deaths a year, while it irreparably limits the cognitive development of children and leads to poor outcomes in pregnancy. Read More

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HIV-Infected Pregnant Women: A Microbial Translocation and Inflammatory Status Discussion.

AIDS Res Hum Retroviruses 2018 Jul 6. Epub 2018 Jul 6.

Botucatu School of Medicine - Sao Paulo State University, Tropical Diseases and Imaging Diagnosis, Botucatu, Sao Paulo, Brazil ;

Background: HIV infection is characterized by impairment of various epithelial protective mechanisms, factors that contribute to intestinal barrier damages and result in microbial translocation, leading to increased immune activation and inflammation. However, microbial translocation and inflammatory status in HIV infection has been poorly investigated during pregnancy, period that the women are susceptible to bacterial infections.

Objectives: We aimed to evaluate microbial translocation and the inflammatory status in HIV-infected pregnant women. Read More

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The Vaginal Microenvironment: The Physiologic Role of .

Front Med (Lausanne) 2018 13;5:181. Epub 2018 Jun 13.

Academic Unit of Reproductive and Developmental Medicine, University of Sheffield, Sheffield, United Kingdom.

In addition to being a passage for sperm, menstruum, and the baby, the human vagina and its microbiota can influence conception, pregnancy, the mode and timing of delivery, and the risk of acquiring sexually transmitted infections. The physiological status of the vaginal milieu is important for the wellbeing of the host as well as for successful reproduction. High estrogen states, as seen during puberty and pregnancy, promote the preservation of a homeostatic (eubiotic) vaginal microenvironment by stimulating the maturation and proliferation of vaginal epithelial cells and the accumulation of glycogen. Read More

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Glycosylation-dependent galectin-receptor interactions promote infection.

Proc Natl Acad Sci U S A 2018 Jun 11;115(26):E6000-E6009. Epub 2018 Jun 11.

Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, C1428ADN Buenos Aires, Argentina;

() constitutes the most prevalent sexually transmitted bacterium worldwide. Chlamydial infections can lead to severe clinical sequelae including pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. As an obligate intracellular pathogen, has evolved multiple strategies to promote adhesion and invasion of host cells, including those involving both bacterial and host glycans. Read More

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June 2018
2 Reads

Equine disease surveillance: quarterly summary.

Authors:

Vet Rec 2018 06;182(23):655-658

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Procalcitonin-guided antibiotic therapy in patients with fever in a general emergency department population: a multicenter noninferiority randomized clinical trial (HiTEMP study).

Clin Microbiol Infect 2018 Jun 2. Epub 2018 Jun 2.

Department of Emergency Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.

Objectives: Overuse of broad-spectrum antibiotics in emergency departments(EDs) results in antibiotic resistance. We determined if procalcitonin(PCT)-guided therapy can be used to reduce antibiotic regimens in EDs by investigating efficacy, safety and accuracy.

Methods: This was a noninferiority multicenter randomized clinical trial, performed in two Dutch hospitals. Read More

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Granulocytic Myeloid-Derived Suppressor Cells (GR-MDSC) in Breast Milk (BM); GR-MDSC Accumulate in Human BM and Modulate T-Cell and Monocyte Function.

Front Immunol 2018 17;9:1098. Epub 2018 May 17.

Department of Neonatology, Tuebingen University Children's Hospital, Tuebingen, Germany.

Nosocomial bacterial infections (NBI) and necrotizing enterocolitis (NEC) are among the main reasons for death in preterm infants. Both are often caused by bacteria coming from the infected infant's gut and feeding with breast milk (BM) seems beneficial in their pathogenesis. However, mechanisms causing the protective effect of BM are only incompletely understood. Read More

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May 2018
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A randomised trial of a contraceptive vaginal ring in women at risk of HIV infection in Rwanda: Safety of intermittent and continuous use.

PLoS One 2018 1;13(6):e0197572. Epub 2018 Jun 1.

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.

Background: Contraceptive vaginal rings could play a role in expanding the contraceptive method mix and in preparing communities for the introduction of HIV prevention and multipurpose rings.

Methods: We conducted an open label single-centre randomised clinical trial of intermittent versus continuous use of NuvaRing® in Kigali, Rwanda, in 2013-2014. We randomised 120 HIV-negative women 1:1 to intermittent use (three rings with a ring-free week in between rings) or continuous use (four rings without ring-free weeks). Read More

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Left lung hypoplasia with a right tuberculous pleural effusion after childbirth: A case report.

Medicine (Baltimore) 2018 May;97(21):e10868

Department of Respiratory Medicine, Qinghai University Affiliated Hospital, Xining, China.

Rationale: Unilateral hypoplasia of the lung is a rare congenital condition, the mechanism of which is poorly understood. Primary pulmonary hypoplasia occurring in an adult is extremely rare and we present what is probably the first case of a link to a tuberculous pleural effusion in a young woman after childbirth.

Patient Concerns: Herein, we describe a 31-year-old woman with left lung hypoplasia, and she not only survived to adulthood without problems, but was able to deliver a baby in natural labor. Read More

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May 2018
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Relation between mycoplasma infection and recurrent spontaneous abortion.

Eur Rev Med Pharmacol Sci 2018 Apr;22(8):2207-2211

Department of Gynecology, Maternal and Child Health Care Hospital, Laiwu City, Shandong Province, China.

Objective: This study explores the possible relation between cervical infections with Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) and the occurrence of recurrent spontaneous abortion (RSA).

Patients And Methods: 132 patients with RSA (observation group) and 96 normal pregnancy volunteers undergoing planned abortions (control group) were selected successively and enrolled in the investigation. Cervical secretion samples were obtained for each subject. Read More

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[Effect of maternal age on pregnancy outcome in patients with structural heart disease].

Authors:
Q Fu J H Lin

Zhonghua Fu Chan Ke Za Zhi 2018 Apr;53(4):221-226

Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.

To analyze the effect of maternal age on pregnancy outcome in patients with structural heart disease. Totally 986 patients diagnosed with structural heart disease who had their delivery at Renji Hospital from January 1st, 2003 to December 31st, 2016 were divided into 5 groups according to maternal age. Sixteen (1. Read More

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April 2018
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Complement C3 opsonization of Chlamydia trachomatis facilitates uptake in human monocytes.

Microbes Infect 2018 Jun - Jul;20(6):328-336. Epub 2018 May 3.

Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 3b, 9220, Aalborg Ø, Denmark. Electronic address:

Chlamydia trachomatis is an obligate intracellular bacterium that causes severe infections, which can lead to infertility and ectopic pregnancy. Although both innate and adaptive immune responses are elicited during chlamydial infection the bacterium succeeds to evade host defense mechanisms establishing chronic infections. Thus, studying the host-pathogen interaction during chlamydial infection is of importance to understand how C. Read More

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Development of a melting-curve based multiplex real-time PCR assay for simultaneous detection of Streptococcus agalactiae and genes encoding resistance to macrolides and lincosamides.

BMC Pregnancy Childbirth 2018 May 3;18(1):126. Epub 2018 May 3.

Departamento de Microbiologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.

Background: Streptococcus agalactiae or Group B Streptococcus (GBS) remains the leading cause of infections in newborns worldwilde. Prenatal GBS screening of pregnant women for vaginal-rectal colonization is recommended in many countries to manage appropriate intrapartum antimicrobial prophylaxis for those identified as carriers. In this study, a novel melting-curve based multiplex real-time PCR assay for the simultaneous detection of GBS and macrolide and lincosamide resistance markers was developed. Read More

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Rheumatic heart disease in pregnancy: a report of 2 cases.

Pan Afr Med J 2017 8;28:298. Epub 2017 Dec 8.

Department of Obstetrics and Gynaecology, University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe.

Pregnant women with severe mitral stenosis tend to experience clinical decompensation with approximately 50% mortality and they may experience adverse effects of the medication they are taking, notably congenital malformations from warfarin exposure. Corrective heart surgery may increase the risk of pregnancy loss. We present 2 cases of RHD in pregnancy. Read More

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May 2018
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Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP).

MMWR Recomm Rep 2018 04 27;67(2):1-44. Epub 2018 Apr 27.

Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, CDC.

This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of tetanus, diphtheria, and pertussis in the United States. As a comprehensive summary of previously published recommendations, this report does not contain any new recommendations and replaces all previously published reports and policy notes; it is intended for use by clinicians and public health providers as a resource. ACIP recommends routine vaccination for tetanus, diphtheria, and pertussis. Read More

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April 2018
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Association between Prior Infection and Ectopic Pregnancy at a Tertiary Care Hospital in South Western Uganda.

Obstet Gynecol Int 2018 1;2018:4827353. Epub 2018 Mar 1.

Mbarara University of Science and Technology, Mbarara, Uganda.

Background: Increase in the number of ectopic pregnancy is attributed to increase in the incidence of pelvic infections. is responsible for most of the sexually transmitted bacterial infections. If undetected and untreated, the infection can ascend to the upper genital tract and cause pelvic inflammatory disease (PID) and related sequelae (ectopic pregnancy and tubal factor infertility). Read More

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March 2018
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A PRISMA systematic review and meta-analysis on Chlamydia trachomatis infections in Iranian women (1986-2015).

Medicine (Baltimore) 2018 Apr;97(16):e0335

Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences.

Background: Chlamydia trachomatis (CT) is the cause of genital tract infections in women. Some evidence has shown the role of this infection with CT in spontaneous abortions. The purpose of this study is to study the frequency of CT infection in Iranian women. Read More

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April 2018
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Adverse effects of maternal enterovirus infection on the pregnancy outcome: a prospective and retrospective pilot study.

Virol J 2018 04 16;15(1):70. Epub 2018 Apr 16.

Service de gynécologie et obstétrique and Risk in pregnancy university department, Hôpital Louis-Mourier, Assistance publique-Hôpitaux de Paris, 178, rue des Renouillers, 92700, Colombes, France.

Background: Enteroviruses account for about one billion infections worldwide each year, the majority remain asymptomatic. Data on enterovirus infections during pregnancy appear to be very rare. Several cases have been reported in the literature of fetal and neonatal complications attributed to these viruses, but prospective data on these infections during pregnancy are not available. Read More

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April 2018
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Honey Bee as Alternative Medicine to Treat Eleven Multidrug-Resistant Bacteria Causing Urinary Tract Infection during Pregnancy.

Sci Pharm 2018 Apr 13;86(2). Epub 2018 Apr 13.

Department of Biology, Faculty of Biology, University 8 May 1945, 24000 Guelma, Algeria.

Medicinal benefits of honey bee have been recognized in the medical community since ancient times as a remedy for many diseases and infections. This study aimed to investigate the susceptibility of 11 multidrug-resistant bacterial strains, isolated from urinary tract infections of pregnant women, to six honey samples collected from different localities in the east of Algeria. The evaluation of the antibacterial activity was performed by the well method followed by the broth dilution method using two-fold dilutions of each honey sample ranging from 2. Read More

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April 2018
2 Reads

Secnidazole (Solosec) for bacterial vaginosis.

Authors:

Med Lett Drugs Ther 2018 Mar;60(1543):52-53

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Group B streptococcus exploits vaginal epithelial exfoliation for ascending infection.

J Clin Invest 2018 May 9;128(5):1985-1999. Epub 2018 Apr 9.

Department of Global Health, University of Washington, Seattle, Washington, USA.

Thirteen percent of pregnancies result in preterm birth or stillbirth, accounting for fifteen million preterm births and three and a half million deaths annually. A significant cause of these adverse pregnancy outcomes is in utero infection by vaginal microorganisms. To establish an in utero infection, vaginal microbes enter the uterus by ascending infection; however, the mechanisms by which this occurs are unknown. Read More

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The Threat of Aerobic Vaginitis to Pregnancy and Neonatal Morbidity.

Afr J Reprod Health 2017 Jun;21(2):108-118

Microbial Endogenous Infections Studies, Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa.

Aerobic vaginitis (AV) is an endogenous opportunistic infection brought about by the disruption of the normal vaginal microbiota. Its early diagnosis and treatment during pregnancy may reduce the risk of negative pregnancy outcomes. The aim of this review was to report on the aerobic bacteria most prevalent in AV and to provide evidence of the threat of untreated AV on pregnancy outcomes. Read More

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June 2017
2 Reads

Performance of QuantiFERON-TB Gold Plus for detection of latent tuberculosis infection in pregnant women living in a tuberculosis- and HIV-endemic setting.

PLoS One 2018 4;13(4):e0193589. Epub 2018 Apr 4.

Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden.

We evaluated the performance of QuantiFERON-TB Gold Plus (QFT-Plus), which includes two Mycobacterium tuberculosis antigen formulations (TB1 and TB2), for detection of latent tuberculosis infection during pregnancy. Eight-hundred-twenty-nine Ethiopian pregnant women (5.9% HIV-positive) were tested with QFT-Plus, with bacteriological sputum analysis performed for women with clinically suspected tuberculosis and HIV-positive women irrespective of clinical presentation. Read More

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July 2018
2 Reads

[Features of local immunity in local inflammatory reactions in pregnant, depending on the implementation of intrauterine infection].

Wiad Lek 2018;71(1 pt 2):168-172

Kharkiv National Medical University, Kharkiv, Ukraine.

Objective: Introduction: Vaginal protective systems function independently of other systemic mechanisms and impairments of local immune mechanisms of the vaginal mucosa are the cause of infectious disorders of the reproductive system The aim: To assess characteristics of local immunity in local inflammatory reactions in pregnant, depending on the implementation of intrauterine infection.

Patients And Methods: Materials and methods: The study comprised Group 1 of pregnant women with the presence of bacterial infections with and without implementation of IUI, Group 2 with the presence of viral infections with and without implementation of IUI, Group 3 with the presence of infections of combined polyetiological structure with and without implementation of IUI and control group included pregnant women with physiological pregnancy. The study implied evaluation of the number of leukocytes in vaginal contents, concentration of IgA, IgM, IgG, sIgA, concentration of cytokines-IL-1 β , IL-6, IL-10, TNF- α in vaginal swabs. Read More

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January 2018

Influenza Vaccination during Pregnancy and Protection against Pertussis.

N Engl J Med 2018 03;378(13):1257-1258

Medical Research Council, Johannesburg, South Africa.

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March 2018
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Motivations of women in Uganda living with rheumatic heart disease: A mixed methods study of experiences in stigma, childbearing, anticoagulation, and contraception.

PLoS One 2018 28;13(3):e0194030. Epub 2018 Mar 28.

Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, United States of America.

Background: Rheumatic heart disease (RHD) is a leading cause of premature mortality in low- and middle-income countries (LMICs). Women of reproductive age are a unique and vulnerable group of RHD patients, due to increased risk of cardiovascular complications and death during pregnancy. Yet, less than 5% of women of childbearing age with RHD in LMICs use contraceptives, and one in five pregnant women with RHD take warfarin despite known teratogenicity. Read More

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Antepartum urinary tract infection and postpartum depression in Taiwan - a nationwide population-based study.

BMC Pregnancy Childbirth 2018 Mar 27;18(1):79. Epub 2018 Mar 27.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

Background: Urinary tract infections (UTIs) are among the most common bacterial infections in pregnant women due to anatomic and physiologic changes in the female urinary tract during pregnancy, and antepartum UTIs can cause adverse pregnancy outcomes that may induce mental stress. There have only been a few studies, however, investigating antepartum UTIs and mental stress. As such, the present study was conducted in order to investigate the association between antepartum UTIs and postpartum depression (PPD). Read More

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March 2018
4 Reads

Tuberculosis during pregnancy in the United States: Racial/ethnic disparities in pregnancy complications and in-hospital death.

PLoS One 2018 26;13(3):e0194836. Epub 2018 Mar 26.

Department of Family and Community Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

Background: Despite decades of efforts to eliminate tuberculosis (TB) in the United States (US), TB still contributes to adverse ill health, especially among racial/ethnic minorities. According to the Centers for Disease Control and Prevention, in 2016, about 87% of the TB cases reported in the US were among racial and ethnic minorities. The objective of this study is to explore the risks for pregnancy complications and in-hospital death among mothers diagnosed with TB across racial/ethnic groups in the US. Read More

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July 2018
4 Reads

Management of herpes zoster (shingles) during pregnancy.

J Obstet Gynaecol 2018 Mar 22:1-8. Epub 2018 Mar 22.

a Medical College of Georgia , Augusta University , Augusta , GA , USA.

An infection with the varicella-zoster virus (VZV) causes both varicella and herpes zoster (HZ). Although rare, the development of HZ does occur during pregnancy. Maternal HZ does not result in increased foetal mortality, and the passage of VZV to the foetus rarely occurs. Read More

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March 2018
1 Read

[Treatment of perineal wounds during the post partum period: evaluation of whether or not antibiotic should be systematically prescribed].

Pan Afr Med J 2017 16;28:144. Epub 2017 Oct 16.

Département de Gynécologie et Obstétriques de la Faculté de Médecine et des Sciences Biomédicales de l'Université de Yaoundé I, Unité de Gynécologie et d'Obstétrique de l'Hôpital Central de Yaoundé, Cameroun.

Introduction: Genital tract integrity is not always mantained during childbirth. No treatment protocol for post-partum perineal wounds (tears and episiotomies) existed in our Department, thus their management depends upon clinician. This study aimed to establish the role of antibiotic in the treatment of post-partum perineal wounds as well as the impact of antibioprophylaxis on wound healing and on prevention of infectious complications after repair. Read More

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April 2018
3 Reads

Effect of maternal infection on gestational weight gain in an urban community of Uganda.

Pan Afr Med J 2017 16;28:145. Epub 2017 Oct 16.

Department of Biochemistry and Sports Science, School of Biolsciences, Makerere University, Kampala, Uganda.

Introduction: Maternal infection has been associated with undesirable effects during pregnancy such as; hyperemesis gravidarum, anemia, intrauterine fetal growth restriction and miscarriage. Our aim was to document the effect of infection on gestational weight gain (GWG) in a low-income urban setting in Uganda.

Methods: This was a prospective cohort study conducted in Kampala between May 2012 and May 2013. Read More

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March 2018
1 Read

[Causes of abortion in horses - overview of the literature and own evaluations].

Tierarztl Prax Ausg G Grosstiere Nutztiere 2018 Feb 21;46(1):35-42. Epub 2018 Feb 21.

The aim of this study was to summarize the current status of the possible causes, clinical symptoms and pathogenesis of abortion in the mare and to evaluate the frequency of varying causes of abortion in German thoroughbred breeding. An analysis of the literature using electronic libraries, journals and textbooks was performed. In addition, the results of examinations of 123 abortions of thoroughbred breeding in central Germany were evaluated. Read More

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February 2018
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[Second Austrian consensus on the safe use of anti-TNFα-antibodies in patients with inflammatory bowel diseases].

Z Gastroenterol 2018 03 12;56(3):275-302. Epub 2018 Mar 12.

Universitätsklinik für Innere Medizin III, Klinische Abteilung für Gastroenterologie und Hepatologie, Medizinische Universität Wien, Wien.

Anti-TNFα-antibodies have revolutionized the therapy of inflammatory bowel diseases and other immune-mediated inflammatory diseases. Due to the increasing application of these substances, the Working Group of Inflammatory Bowel Diseases of the Austrian Association of Gastroenterology and Hepatology intended to update their consensus report on the safe use of Infliximab (published in 2010) and to enlarge its scope to cover all anti-TNFα-antibodies. The present consensus report summarizes the current evidence on the safe use of anti-TNFα-antibodies and covers the following topics: general risk of infection, bacterial infections (i. Read More

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March 2018
4 Reads

[Odontogenic foci and systemic diseases. A review].

Orv Hetil 2018 Mar;159(11):415-422

Konzerváló és Esztétikai Fogászati Tanszék, Szegedi Tudományegyetem, Fogorvostudományi Kar Szeged.

The aim of the present review is to provide an up-to-date picture of what we know about the connection between odontogenic foci and non-oral diseases. After a brief historical summary, we give an overview on how the odontogenic focus causes disease in distant areas of the body in general, and then we start the discussion of the particular conditions, such as cardiovascular diseases, pneumonia, diabetes mellitus, metabolic syndrome, rheumatoid arthritis and adverse pregnancy outcomes. The review is centered around the two main odontogenic foci: periodontitis and periapical periodontitis, the latter being a widely recognized but rarely discussed oral focus. Read More

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March 2018
2 Reads

Equine disease surveillance: quarterly summary.

Authors:

Vet Rec 2018 03;182(10):282-286

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A care bundle including antenatal corticosteroids reduces preterm infant mortality in Tanzania a low resource country.

PLoS One 2018 7;13(3):e0193146. Epub 2018 Mar 7.

Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States of America.

Background: Preterm neonatal mortality (NM) has remained high and unchanged for many years in Tanzania, a resource-limited country. Major causes of mortality include birth asphyxia, respiratory insufficiency and infections. Antenatal corticosteroids (ACS) have been shown to significantly reduce mortality in developed countries. Read More

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[Progress on influencing factors regarding the neonatal group B streptococcal infectious diseases].

Authors:
X Hong H Yu B Wang

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Feb;39(2):249-252

Department of Epidemiology and Health Statistics, School of Public Health, Southeast University; Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Nanjing 210009, China.

Group B streptococcus (GBS) is one of the severe pathogenic bacteria during the perinatal period, both on pregnant women and newborns. GBS infection may lead to pneumonia, septicemia, meningitis or other severe disease, even death in neonates. Although only 1%-2% infections will develop into GBS disease among the neonates, the etiological mechanism of which is worth researching. Read More

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February 2018

Acquisition of extended spectrum beta-lactamase-producing enterobacteriaceae in neonates: A community based cohort in Madagascar.

PLoS One 2018 1;13(3):e0193325. Epub 2018 Mar 1.

Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases Unit, Institut Pasteur, INSERM, UVSQ, Paris, France.

In low and middle income countries (LMICs), where the burden of neonatal sepsis is the highest, the spread of extended spectrum beta-lactamase-producing enterobacteriaceae (ESBL-PE) in the community, potentially contributing to the neonatal mortality, is a public health concern. Data regarding the acquisition of ESBL-PE during the neonatal period are scarce. The routes of transmission are not well defined and particularly the possible key role played by pregnant women. Read More

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June 2018
6 Reads

Trends in adult chlamydia and gonorrhoea prevalence, incidence and urethral discharge case reporting in Mongolia from 1995 to 2016 - estimates using the Spectrum-STI model.

Western Pac Surveill Response J 2017 Oct-Dec;8(4):20-29. Epub 2017 Dec 1.

Avenir Health, Geneva, Switzerland.

Objective: To estimate Mongolia's prevalence and incidence trends of gonorrhoea and chlamydia in women and men 15-49 years old to inform control of STIs and HIV, a national health sector priority.

Methods: We applied the Spectrum-STI estimation model, fitting data from two national population surveys (2001 and 2008) and from routine gonorrhoea screening of pregnant women in antenatal care (1997 to 2016) adjusted for diagnostic test performance, male/female differences and missing high-risk populations. Prevalence and incidence estimates were then used to assess completeness of national case reporting. Read More

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Integrating HIV, hepatitis B and syphilis screening and treatment through the Maternal, Newborn and Child Health platform to reach global elimination targets.

Western Pac Surveill Response J 2017 Oct-Dec;8(4):1-5. Epub 2017 Dec 31.

Division of Communicable Disease, World Health Organization Regional Office for the Western Pacific, Manila, Philippines.

Every year, an estimated 180 000 babies in the Western Pacific Region are infected by hepatitis B, 13 000 by syphilis and 1400 by HIV through mother-to-child transmission. () These infections can be largely prevented by antenatal screening, treatment and timely vaccination for newborns. Despite challenges in controlling each disease, major achievements have been made. Read More

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Aminomethyl Spectinomycins as Therapeutics for Drug-Resistant Gonorrhea and Chlamydia Coinfections.

Antimicrob Agents Chemother 2018 May 26;62(5). Epub 2018 Apr 26.

Microbiotix, Inc., Worcester, Massachusetts, USA.

Bacterial sexually transmitted infections are widespread and common, with (gonorrhea) and (chlamydia) being the two most frequent causes. If left untreated, both infections can cause pelvic inflammatory disease, infertility, ectopic pregnancy, and other sequelae. The recommended treatment for gonorrhea is ceftriaxone plus azithromycin (to empirically treat chlamydial coinfections). Read More

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May 2018
11 Reads

Parallel detection of lactobacillus and bacterial vaginosis-associated bacterial DNA in the chorioamnion and vagina of pregnant women at term.

J Matern Fetal Neonatal Med 2018 Mar 12:1-9. Epub 2018 Mar 12.

c Fred Hutchinson Cancer Research Center , Seattle, Washington , DC , USA.

Background: The majority of early preterm births are associated with intrauterine infections, which are thought to occur when microbes traffic into the uterus from the lower genital tract and seed the placenta. Bacterial vaginosis (BV) is associated with heterogeneous bacterial communities in the vagina and is linked to preterm birth. The extent to which trafficking into the uterus of normal and BV-associated vaginal bacteria occurs is unknown. Read More

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March 2018
2 Reads

BCG vaccines: WHO position paper – February 2018.

Authors:

Wkly Epidemiol Rec 2018 Feb 23;93(8):73-96. Epub 2018 Feb 23.

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February 2018
1 Read

infection causing arthritis and pneumonia in cattle.

Authors:

Vet Rec 2018 02;182(8):216-220

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February 2018
1 Read

Antibiotics for treating gonorrhoea in pregnancy.

Cochrane Database Syst Rev 2018 02 21;2:CD011167. Epub 2018 Feb 21.

Departamento de Obstetricia y Ginecología, Universidad de Carabobo, Urbanización Fundación Mendoza calle 19, 5ta etapa N° 22-40, Valencia, Estado Carabobo, Venezuela, 2001.

Background: Gonorrhoea is a sexually transmitted infection that is caused by Neisseria gonorrhoeae, and is a major public health challenge today. N gonorrhoeae can be transmitted from the mother's genital tract to the newborn during birth, and can cause gonococcal ophthalmia neonatorum as well as systemic neonatal infections. It can also cause endometritis and pelvic sepsis in the mother. Read More

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February 2018

Prevalence of Streptococcus agalactiae colonization in pregnant women from the 18th Health Region of Paraná State.

Rev Inst Med Trop Sao Paulo 2018 15;60:e2. Epub 2018 Feb 15.

Departamento de Pós Graduação em Ciências da Saúde, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.

Introduction The aim of this study was to determine the prevalence of GBS colonization in pregnant women in a public health service. Methods A study of 496 pregnant women at 35-37 gestational weeks was conducted from September 2011 to March 2014 in 21 municipalities of the 18th Health Region of Paraná State. Vaginal and anorectal samples of each woman were plated on sheep blood agar, and in HPTH and Todd-Hewitt enrichment broths. Read More

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March 2018
1 Read

Haemolytic-uremic syndrome due to infection with adenovirus: A case report and literature review.

Medicine (Baltimore) 2018 Feb;97(7):e9895

Lucian Blaga University of Sibiu, Faculty of Medicine Sibiu, Romania.

Rationale: Haemolytic-uremic syndrome is a rare but serious complication of bacterial and viral infections, which is characterized by the triad of: acute renal failure, microangiopathic haemolytic anemia and thrombocytopenia, sometimes severe, requiring peritoneal dialysis. In Europe, hemolytic-uremic syndrome (HUS) in paediatric pathology is primarily caused by Shiga toxin-producing Escherichia coli (STEC) O157, followed by O26. Beside these etiologies, there are other bacterial and viral infections, and also noninfectious ones that have been associated to lead to HUS as well: in the progression of neoplasia, medication-related, post-transplantation, during pregnancy or associated with the antiphospholipid syndrome, systemic lupus erythematosus or family causes with autosomal dominant or recessive inheritance. Read More

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February 2018
8 Reads

Lack of association between Leptospira spp. serovars Hardjobovis and Pomona and pregnancy and mid-term abortion in New Zealand farmed red deer.

Vet Microbiol 2018 Feb 27;215:83-89. Epub 2018 Jan 27.

EpiCentre, IVABS, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand.

This paper investigates Leptospira borgpeterseni serovar Hardjobovis and L. interrogans serovar Pomona as potential causes of sub-optimum pregnancy rates and mid-term abortion in farmed red deer. Rising two-year-old (R2, n = 22,130) and mixed-age (MA, n = 36,223) hinds from 87 and 71 herds, respectively, throughout New Zealand were ultrasound scanned early in gestation (Scan-1) and a sub-sample re-scanned (Scan-2) 55-89 days later and mid-term daily abortion rate calculated. Read More

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February 2018
2 Reads

Protective effect of Group B Streptococcus type-III polysaccharide conjugates against maternal colonization, ascending infection and neonatal transmission in rodent models.

Sci Rep 2018 Feb 7;8(1):2593. Epub 2018 Feb 7.

GSK, Siena, Italy.

Group B Streptococcus (GBS) is a normal inhabitant of recto-vaginal mucosae in up to 30% of healthy women. Colonization is a major risk factor for perinatal infection which can lead to severe complications such as stillbirth and neonatal invasive disease. Intra-partum antibiotic prophylaxis in colonized women is a safe and cost-effective preventive measure against early-onset disease in the first days of life, but has no effect on late-onset manifestations or on early maternal infection. Read More

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February 2018
9 Reads