Role of tumor necrosis factor-α in Gram-negative bacterial lipopolysaccharides induced implantation failure.
Reprod Med Biol 2005 Mar 7;4(1):79-88. Epub 2005 Mar 7.
Molecular Biology and Reproductive Immunology Laboratory, School of Studies in Biochemistry, Jiwaji University, Gwalior, and.
Gram-negative bacterial lipopolysaccharides (LPS) are known causative agents for pregnancy loss in mothers with genital tract infections. In this study, we attempt to test the role of tumor necrosis factor-α (TNF-α) in the normal physiological processes of preimplantation embryonic development and LPS induced pregnancy loss in mice. Since the preimplantation mouse embryos grow in an unattached state for a considerable period (day 1-4. Read More