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Genomics 2019 Mar 19. Epub 2019 Mar 19.

School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690 525, Kerala, India. Electronic address:

Bartonella henselae is a facultative intracellular pathogen that occurs worldwide and is responsible primarily for cat-scratch disease in young people and bacillary angiomatosis in immunocompromised patients. The principal source of genome-level diversity that contributes to B. henselae's host-adaptive features is thought to be horizontal gene transfer events. Read More

Ticks Tick Borne Dis 2019 02 27;10(2):360-364. Epub 2018 Nov 27.

Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University (NCSU), 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address:

The objective of this work was to determine the prevalence of Borrelia and Bartonella species in Ixodes spp. ticks collected from 16 USA states. Genus PCR amplification and sequence analysis of Bartonella and Borrelia 16SsRNA-23SsRNA intergenic regions were performed on DNA extracted from 929 questing adult ticks (671 Ixodes scapularis, 155 Ixodes affinis, and 103 Ixodes pacificus). Read More

Parasit Vectors 2018 Dec 4;11(1):624. Epub 2018 Dec 4.

Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

Bartonellosis is a vector-borne zoonotic disease with worldwide distribution that can infect humans and a large number of mammals including small companion animals (cats and dogs). In recent years, an increasing number of studies from around the world have reported Bartonella infections, although publications have predominantly focused on the North American perspective. Currently, clinico-pathological data from Europe are more limited, suggesting that bartonellosis may be an infrequent or underdiagnosed infectious disease in cats and dogs. Read More

Vet Dermatol 2018 Dec 14;29(6):537-e180. Epub 2018 Oct 14.

Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, 1050 William Moore Drive, Raleigh, NC, 27607, USA.

Background: Bartonella henselae, a Gram-negative, zoonotic, alpha-proteobacteria has been previously implicated in association with cutaneous vasoproliferative lesions (bacillary angiomatosis), nodular panniculitis and multifocal erythema (erythema multiforme) in dogs.

Objective: Describe clinical, microbiological and histological lesions in a dog with ear margin vasculitis and B. henselae infection. Read More

Am J Case Rep 2018 Aug 2;19:906-911. Epub 2018 Aug 2.

Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

BACKGROUND Bartonella infection is the causative organism of cat-scratch disease (CSD), which typically presents with self-limited localized lymphadenopathy. In HIV-infected patients, Bartonella infection can cause systemic illnesses with significant morbidity and mortality manifesting as bacillary angiomatosis (BA), hepatic peliosis, splenitis, bacteremic febrile illness, and other organ involvement. To the best of our knowledge, there have been no reports of HIV-infected patients presenting with generalized lymphadenopathy caused by Bartonella infection. Read More

Indian Dermatol Online J 2018 May-Jun;9(3):205-206

Department of Dermatology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

Can J Ophthalmol 2018 04 22;53(2):e69-e71. Epub 2017 Sep 22.

Department of Ophthalmology and Vision Sciences, Hospital for Sick Children, Toronto, Ont; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ont.

Vet Microbiol 2018 Mar 9;216:119-122. Epub 2018 Feb 9.

Anatomy, Physiology, and Pharmacology Academic Program, School of Veterinary Medicine, St. George's University, St. George's, Grenada, West Indies.

Many mammals are established hosts for the vector borne bacterial genus, Bartonella. Small Indian mongooses (Herpestes auropunctatus) have only been reported as a possible host for Bartonella henselae in southern Japan. Confirming Bartonella presence in mongooses from other regions in the world may support their role as potential reservoirs of this human pathogen. Read More

Vet Clin Pathol 2018 Mar 2;47(1):45-50. Epub 2018 Feb 2.

Department of Clinical Sciences, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

Ineffective erythropoiesis was diagnosed in an 8-year-old male castrated Labrador Retriever. Despite treatment with immunosuppressive therapy for suspected immune-mediated erythrocyte maturation arrest, resolution of the nonregenerative anemia was not achieved. Following documentation of Bartonella henselae bacteremia by Bartonella alpha proteobacteria growth medium (BAPGM) enrichment blood culture, immunosuppressive therapy was discontinued, and the anemia resolved following prolonged antibiotic therapy. Read More

Rev Inst Med Trop Sao Paulo 2017 Aug 24;59:e59. Epub 2017 Aug 24.

Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Hantaviroses e Rickettsioses, Rio de Janeiro, Rio de Janeiro, Brazil.

Bacillary angiomatosis (BA) is an angioproliferative disease of immunocompromised patients that usually presents as vascular tumors in the skin and subcutaneous tissues. It is caused by chronic infections with either Bartonella henselae or B. quintana. Read More

Epidemiol Mikrobiol Imunol Summer 2017;66(2):99-104

Cat scratch disease is a relatively rare infection that is caused by the bacterium Bartonella henselae. This disease occurs after cat scratch or bite. The course of the disease depends on the patients immunity status. Read More

Appl Environ Microbiol 2017 06 31;83(12). Epub 2017 May 31.

Departamento de Biología Molecular and Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-SODERCAN, Santander, Spain

Bacterial conjugation is a mechanism of horizontal DNA transfer. The relaxase TrwC of the conjugative plasmid R388 cleaves one strand of the transferred DNA at the gene, covalently attaches to it, and leads the single-stranded DNA (ssDNA) into the recipient cell. In addition, TrwC catalyzes site-specific integration of the transferred DNA into its target sequence present in the genome of the recipient bacterium. Read More

J Int Assoc Provid AIDS Care 2017 Jul/Aug;16(4):321-323. Epub 2017 Apr 10.

2 Divisions of General Internal Medicine and Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.

Bacillary angiomatosis (BA) is a rare complication of human immune deficiency virus (HIV) infection in the post-antiretroviral therapy (ART) era, and few cases of BA-associated immune reconstitution inflammatory syndrome (IRIS) have been described. We report the case of a 50-year-old man who presented with mass lesions involving the skin, subcutaneous tissues, muscle, and bone. The diagnosis of Bartonella quintana BA was confirmed by serum polymerase chain reaction. Read More

J Vet Sci 2017 Dec;18(4):541-545

Research institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.

In this study, we examine prevalences of three infectious pathogens with different transmission modes (, hemoplasma, and ) in feral cats from urban and rural habitats. Infection status of the three pathogens in blood samples (n = 117) was determined through molecular or serological diagnostic methods. Overall prevalence of hemoplasma, , and was 47. Read More

Vet Clin Pathol 2017 Jun 6;46(2):326-330. Epub 2017 Mar 6.

Department of Physiological Sciences, University of Florida, Gainesville, FL, USA.

Background: Previous reports suggest an association between Bartonella infection and effusions in dogs and human beings.

Objectives: The aims of this study were to determine the prevalence of Bartonella infection in canine effusions and to investigate historic and clinical parameters predictive of Bartonella in dogs with effusions.

Methods: Canine cavitary effusions submitted for analysis and, if available, paired EDTA blood, were screened for Bartonella infection using the Bartonella α-proteobacteria growth medium enrichment culture/PCR diagnostic platform (Bartonella enrichment PCR or ePCR) at Galaxy Diagnostics, Inc. Read More

Anal Chem 2017 01 7;89(2):1163-1169. Epub 2016 Dec 7.

Department of Bionano Engineering, Hanyang University , Ansan 426-791, South Korea.

A new class of surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor has been developed for the simultaneous detection of dual DNA markers. The LFA strip in this sensor was composed of two test lines and one control line. SERS nano tags labeled with detection DNA probes were used for quantitative evaluation of dual DNA markers with high sensitivity. Read More

Microb Ecol 2017 08 2;74(2):474-484. Epub 2017 Feb 2.

Microbial Pathogenesis and Host Defense Program, University of California, San Francisco, San Francisco, CA, 94143-0654, USA.

Bartonella henselae is an emerging bacterial pathogen causing cat-scratch disease and potentially fatal bacillary angiomatosis in humans. Bacteremic cats constitute a large reservoir for human infection. Although feline vaccination is a potential strategy to prevent human infection, selection of appropriate B. Read More

An Bras Dermatol 2016 Nov-Dec;91(6):811-814

Universidade Federal do Espírito Santo (UFES) - Vitória (ES), Brazil.

Bacillary angiomatosis is an infection determined by Bartonella henselae and B. quintana, rare and prevalent in patients with acquired immunodeficiency syndrome. We describe a case of a patient with AIDS and TCD4+ cells equal to 9/mm3, showing reddish-violet papular and nodular lesions, disseminated over the skin, most on the back of the right hand and third finger, with osteolysis of the distal phalanx observed by radiography. Read More

JAAD Case Rep 2016 Nov 5;2(6):454-456. Epub 2016 Dec 5.

Department of Dermatology, Rush University, Chicago, Illinois.

J Vet Emerg Crit Care (San Antonio) 2016 Nov 13;26(6):851-857. Epub 2016 Apr 13.

Oradell Animal Hospital, Paramus, NJ, 07652.

Objective: To describe a case of hemoperitonium in a dog with Bartonellosis and peliosis hepatis (PH) lesions that resolved following antimicrobial therapy.

Case Summary: A 3-year-11-month-old 22.5 kg female spayed mixed breed dog presented for progressive lethargy and vomiting. Read More

Pediatr Emerg Care 2016 Nov;32(11):789-791

From the *Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill; †Departments of Emergency Medicine and Pediatric Emergency Medicine; ‡Department of Pediatrics, Pediatric Critical Care, WakeMed Health and Hospitals, Raleigh, NC; and §Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC.

Despite the publication of a number of case reports since the 1950s, physician awareness of the unique relationship between cat scratch disease (CSD) and acute encephalopathy remains limited. This report alerts emergency medicine physicians to include CSD encephalopathy (CSDE) in the differential diagnosis when a previously healthy child presents with status epilepticus. Prompt recognition of this relationship impacts the selection of initial diagnostic studies and antibiotic choices and permits reliable insight into prognosis. Read More

Microbiologyopen 2017 04 28;6(2). Epub 2016 Oct 28.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Bartonella henselae is a gram-negative zoonotic bacterium that causes infections in humans including endocarditis and bacillary angiomatosis. B. henselae has been shown to grow as large aggregates and form biofilms in vitro. Read More

Indian J Dermatol Venereol Leprol 2017 Jan-Feb;83(1):99-101

Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Am J Dermatopathol 2016 Nov;38(11):793-801

*Resident, Department of Pathology, Hospital 12 de Octubre, Madrid, Spain; †Dermatologist, Dermatopathologie Friedrichshafen, Friedrichshafen, Germany; ‡Dermatologist, Department of Pathology, Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain; and §Pathologist, Department of Pathology, Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain.

Infectious angiogenesis is the biological response of neoangiogenesis induced by infectious organisms. The authors present 3 exemplary entities which show paradigmatic clinico-pathological settings of infectious angiogenesis: Bacillary angiomatosis, Orf (ecthyma contagiosum), and Kaposi sarcoma. The authors review the literature and elucidate etiopathogenetic pathways leading to the phenomenon of neovascularization stimulated by infectious organisms. Read More

IDCases 2016 4;6:77-78. Epub 2016 Oct 4.

Division of Anatomical Pathology, Stellenbosch University and National Health Laboratory Service, Tygerberg Hospital, Parow, South Africa.

Gastroenterology 2016 Nov 6;151(5):e3-e4. Epub 2016 Oct 6.

Department of Gastroenterology, Chienkuo Technology University Changhua, Taiwan; General Education Center, Chienkuo Technology University Changhua, Taiwan.

Medicine (Baltimore) 2016 Jul;95(28):e4155

aInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology bDivision of Immunology, Allergy and Infectious Diseases, Department of Dermatology cClinical Institute for Pathology dDepartment of Radiology and Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Background: The clinical manifestation of bacillary angiomatosis (BA) can be limited to one organ, most commonly the skin, but systemic courses can also occur. We report a human immunodeficiency virus (HIV)-positive patient with a systemic manifestation of BA caused by Bartonella quintana, diagnosed in Vienna, Austria. The pathogen was detected in multiple organs including a facial tumor which is an unusual finding for BA. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Aug 12;122(2):e51-4. Epub 2016 May 12.

Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands.

Here, we report chronic suppurating submandibular swelling occurring in two siblings, with one case caused by nontuberculous mycobacteria and the other caused by Bartonella henselae. These two infections share a similar clinical presentation, but the treatment modalities differed. Read More

Lancet Infect Dis 2016 08 30;16(8):e164-72. Epub 2016 Jun 30.

Medicine Service, South Texas Veterans Health Care System, San Antonio, TX, USA; Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Electronic address:

In 1915, a British medical officer on the Western Front reported on a soldier with relapsing fever, headache, dizziness, lumbago, and shin pain. Within months, additional cases were described, mostly in frontline troops, and the new disease was called trench fever. More than 1 million troops were infected with trench fever during World War 1, with each affected soldier unfit for duty for more than 60 days. Read More

Rev Esp Salud Publica 2016 May 5;90:E5. Epub 2016 May 5.

Departamento de Patología Animal. Facultad de Veterinaria de Zaragoza. Zaragoza. España.

Objective: Bartonella henselae is responsible for the Cat Scratch Disease in humans, being it underdiagnosed. This study aims to detect and quantify the load of B. henselae DNA in oral and whole blood samples from stray and shelthered cats from Zaragoza (Spain), and analyze associations with epidemiological and clinical factors. Read More

JAAD Case Rep 2016 Jan 4;2(1):77-9. Epub 2016 Feb 4.

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

J Trop Dis Public Health 2016 Apr 20;4(2). Epub 2016 Feb 20.

Division of Dermatology, Department of Medicine, State University of Campinas, Medical Sciences School, Campinas, Brazil.

is a causative agent of anemia, cat scratch disease, bacillary angiomatosis, recurrent fever, hepatitis, endocarditis, chronic lymphadenopathy, joint and neurological disorders. are intra-erythrocytic bacteria. The goal of this study was to visualize the invasion into enucleated human red blood cells in real time using bacterium endogenous fluorescence. Read More

PLoS Negl Trop Dis 2016 Mar 21;10(3):e0004509. Epub 2016 Mar 21.

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Bacteria from the genus Bartonella are emerging blood-borne bacteria, capable of causing long-lasting infection in marine and terrestrial mammals, including humans. Bartonella are generally well adapted to their main host, causing persistent infection without clinical manifestation. However, these organisms may cause severe disease in natural or accidental hosts. Read More

Transfusion 2016 06 10;56(6 Pt 2):1556-9. Epub 2016 Mar 10.

Division of Dermatology, Department of Medicine, University of Campinas (UNICAMP) Medical School, Campinas, SP, Brazil.

Background: Bartonella spp. are neglected fastidious Gram-negative bacilli. We isolated Bartonella henselae from 1. Read More

Tunis Med 2015 Jul;93(7):478-9

Infect Immun 2015 Dec 28;84(3):711-22. Epub 2015 Dec 28.

University Hospital, Goethe-University, Institute for Medical Microbiology and Infection Control, Frankfurt am Main, Germany

Bacterial adherence determines the virulence of many human-pathogenic bacteria. Experimental approaches elucidating this early infection event in greater detail have been performed using mainly methods of cellular microbiology. However, in vitro infections of cell monolayers reflect the in vivo situation only partially, and animal infection models are not available for many human-pathogenic bacteria. Read More

S Afr Med J 2015 Oct;105(10):874

An HIV-positive 39-year-old man presented with generalised nodular lesions. He was apyrexial and normotensive, with a normal respiratory rate. The rest of the examination was normal. Read More

Am J Surg Pathol 2016 Mar;40(3):342-7

Mayo Clinic, Division of Hematopathology, Rochester, MN.

Bartonella henselae lymphadenitis, or cat-scratch lymphadenitis (CSL), is classically associated with stellate microabscesses, occasional giant cells, and extension of the inflammatory infiltrate into perinodal soft tissue. Availability of B. henselae molecular testing on tissue specimens has broadened our understanding of the morphologic variation in this disease. Read More

Indian J Dermatol 2015 Sep-Oct;60(5):523

Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.

Bacillary angiomatosis is an infectious disease caused by two Gram-negative bacilli; this disease usually affects immunosuppressed hosts with a history of cat scratch. We report a rare case of bacillary angiomatosis in an immunocompetent 26-year-old woman with no history of exposure to cats, and with atypical clinical features (very pruritic vascular papules and nodules with ulceration and hemorrhage on the right arm and fingers). She was successfully treated with clarithromycin for 3 months. Read More

Eur J Dermatol 2015 May-Jun;25(3):268-9

Department of Dermatology.

Indian J Sex Transm Dis AIDS 2015 Jan-Jun;36(1):92-4

Department of STD, SHIFA Hospitals, Tirunelveli, Tamil Nadu, India.

A 14 year old boy, said to have had multiple transfusions during infancy, was brought to the hospital for complaints of pain over right thigh for one week duration. MRI reveals multiple osteolytic lesions with enhancing hyperintense bone marrow lesions over iliac bones, right acetabulum and lumbar vertebral bodies and enlarged para-aortic, iliac and inguinal lymph nodes. CT of the whole body revealed osteolytic lesions on skull, mandible, right scapula, head of both humeri, L1 and L4 vertebrae, 5(th) and 10(th) ribs, both acetabulum and ala of sacrum along with enlargement of cervical, axillary and mesenteric, iliac and inguinal nodes. Read More

Am J Dermatopathol 2015 Oct;37(10):771-2, 799-800

Division of Dermatology and Cutaneous Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX.

J Echocardiogr 2015 Jun 18;13(2):66-8. Epub 2015 Mar 18.

Department of Laboratory Medicine, Kameda Medical Center, 929 Higashicho, Kamogawa, Japan.

A 61-year-old male presented with fever. He had a history of aortic valve replacement, and infective endocarditis was suspected. The transthoracic and transesophageal echocardiography on admission could not detect vegetation, and all blood cultures obtained were negative. Read More

Indian J Dermatol Venereol Leprol 2015 Jul-Aug;81(4):398-400

Department of Dermatology and Venereology, Hospital Garcia de Orta, Almada, Portugal.

Ann Cardiol Angeiol (Paris) 2016 Feb 19;65(1):48-50. Epub 2015 Jan 19.

Service de cardiologie, hôpital d'instruction des armées Desgenettes, 108, boulevard Pinel, 69275 Lyon cedex 03, France.

We report a case of blood culture-negative tricuspid infective endocarditis revealed after tick bite by repeated pulmonary infection during one year due to septic pulmonary emboli in a 67-year-old farmer woman. Tricuspid vegetation and pulmonary emboli are calcified. Lyme serology is negative. Read More

Rev Chilena Infectol 2015 Feb;32 Suppl 1:S57-71

The ongoing human immunodeficiency virus (HIV) infection epidemic coupled with more efficacious and available treatments has led to a larger number of patients living with HIV or AIDS. As a result, skin manifestations related to HIV/AIDS or its therapy have become increasingly more common and are reported to occur in as many as 95% of patients. Herein, we review the most common HIV/AIDS related cutaneous pathologies and classify them into inflammatory, HAART-associated, neoplastic, and infectious manifestations. Read More

Cell Microbiol 2015 Oct 19;17(10):1447-63. Epub 2015 May 19.

Institute for Medical Microbiology and Infection Control, Goethe University, Frankfurt am Main, Germany.

The contribution of myeloid cells to tumour microenvironments is a decisive factor in cancer progression. Tumour-associated macrophages (TAMs) mediate tumour invasion and angiogenesis through matrix remodelling, immune modulation and release of pro-angiogenic cytokines. Nothing is known about how pathogenic bacteria affect myeloid cells in these processes. Read More

Transpl Infect Dis 2015 Jun 1;17(3):411-7. Epub 2015 Jun 1.

Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Bartonella henselae (BH) is the main cause of cat scratch disease (CSD), which more typically presents as a self-limited localized suppurative lymphadenopathy in immunocompetent individuals. In contrast, immunocompromised patients commonly have systemic disease with life-threatening complications. In addition to the angioproliferative lesions, such as bacillary angiomatosis, an increasing number of immune post-infectious complications are being recognized with BH infections, including glomerulonephritis, vasculitis, hemophagocytic syndrome, and neurological problems. Read More

J Clin Microbiol 2015 May 4;53(5):1556-61. Epub 2015 Mar 4.

Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

Bartonella species constitute emerging, vector-borne, intravascular pathogens that produce long-lasting bacteremia in reservoir-adapted (natural host or passive carrier of a microorganism) and opportunistic hosts. With the advent of more sensitive and specific diagnostic tests, there is evolving microbiological evidence supporting concurrent infection with one or more Bartonella spp. in more than one family member; however, the mode(s) of transmission to or among family members remains unclear. Read More