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Med Clin North Am 2022 May 4;106(3):527-536. Epub 2022 Apr 4.

University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address:

Human immunodeficiency virus (HIV)-associated disease is known for its protean manifestations. However, many of the characteristic findings on physical examination are not associated with HIV infection per se but the numerous opportunistic infections (OIs) that are common in patients with advanced HIV disease. Common findings of acute HIV infection include fever, adenopathy, rash, and oral ulcers. Read More

Front Microbiol 2022 7;13:838267. Epub 2022 Feb 7.

Institute for Medical Microbiology and Infection Control, University Hospital, Goethe University, Frankfurt am Main, Germany.

is the causative agent of cat scratch disease and other clinical entities such as endocarditis and bacillary angiomatosis. The life cycle of this pathogen, with alternating host conditions, drives evolutionary and host-specific adaptations. Human, feline, and laboratory adapted isolates often display genomic and phenotypic differences that are related to the expression of outer membrane proteins, for example the adhesin A (BadA). Read More

Dermatol Pract Concept 2021 Oct 1;11(4):e2021088. Epub 2021 Oct 1.

Institute of Histopathology, Histonor, Antofagasta, Chile.

BMJ Case Rep 2021 Dec 1;14(12). Epub 2021 Dec 1.

Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland.

We describe the case of a 30-year-old man who presented to our institution with hypoxia and widespread pulmonary infiltrates managed initially as COVID-19 before receiving a new diagnosis of HIV-associated Kaposi sarcoma (KS) with widespread pulmonary and skeletal involvement. Initial differential diagnoses included pneumonia, disseminated mycobacterial infection and bacillary angiomatosis. A bone marrow biopsy showed heavy infiltration by spindle cells, staining strongly positive for human herpes virus-8 (HHV-8) and CD34, suggesting symptomatic, disseminated KS as the unifying diagnosis. Read More

IDCases 2021 11;26:e01306. Epub 2021 Oct 11.

Department of Pediatrics and Adolescent Medicine, Western Michigan University Homer Stryker MD School of Medicine, 1000 Oakland Dr, Kalamazoo, MI 49008, USA.

species are Gram-negative bacilli and fastidious bacteria that can cause a number of clinical syndromes, including blood culture-negative infective endocarditis (IE). The two most commonly isolated species in humans are the agent of trench fever, and mostly known for causing cat scratch disease (Edouard et al., 2015 [1]; Edouard and Raoult, 2010 [2]). Read More

Proc (Bayl Univ Med Cent) 2021 Sep 10;34(5):593-594. Epub 2021 Jun 10.

Department of Infection Control and Antimicrobial Stewardship, Mercy Catholic Medical Center, Darby, Pennsylvania.

infection, or cat scratch disease, typically is a self-limiting disease presenting as lymphadenopathy and fever after a bite or scratch from a cat. The most commonly reported presentation in immunocompromised patients includes bacillary angiomatosis and peliosis hepatitis, which resemble Kaposi's sarcoma. Isolated hepatosplenic abscess without diffuse lymphadenopathy or vasoproliferative disease is seldom reported in adult immunocompromised patients. Read More

South Afr J HIV Med 2021 20;22(1):1257. Epub 2021 Jul 20.

Department of Anatomical Pathology, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory Services, Johannesburg, South Africa.

Int J Dermatol 2021 Jul 10. Epub 2021 Jul 10.

Division of Dermatology, University of Kansas Medical Center, Kansas City, KS, USA.

Transpl Infect Dis 2021 Aug 8;23(4):e13670. Epub 2021 Jul 8.

Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH, USA.

Bacillary angiomatosis (BA) is an uncommon systemic disease caused by Bartonella henselae (BH) or Bartonella quintana (BQ) that occurs primarily in immunocompromised hosts. Few cases of BA recipients have been reported in adult solid transplant recipients over the years, with most cases presenting years after transplant. We describe a case of a kidney transplant recipient who developed cutaneous BA very early in the post-transplant period despite not having any exposures. Read More

Pediatr Infect Dis J 2021 05;40(5S):S11-S15

From the Division of Pediatric Infectious Diseases, Harbor-UCLA Medical Center, Los Angeles, California.

Since the early 1900s, Bartonella species were known only to cause human disease resulting from very restricted geographic (bartonellosis) or environmental influences ("trench fever"). In the 1990s, and in parallel, cat scratch disease and bacillary angiomatosis were definitively linked to Bartonella species. Subsequently, widespread use of modern diagnostic methods revealed the broad ecologic niche of this organism and greatly expanded our knowledge of the epidemiology and clinical presentations associated with this genus. Read More

Infect Immun 2021 07 15;89(8):e0014121. Epub 2021 Jul 15.

Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.

Some bacterial pathogens can manipulate the angiogenic response, suppressing or inducing it for their own ends. In humans, Bartonella henselae is associated with cat-scratch disease and vasculoproliferative disorders such as bacillary angiomatosis and bacillary peliosis. Although endothelial cells (ECs) support the pathogenesis of , the mechanisms by which induces EC activation are not completely clear, as well as the possible contributions of other cells recruited at the site of infection. Read More

Skinmed 2021 1;19(2):150-154. Epub 2021 Apr 1.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL;

A 37-year-old man with a history of renal transplantation in 2013 due to focal segmental glomerulosclerosis presented to the emergency room with a 2-week history of fever, chills, anorexia, weight loss, abdominal pain, diarrhea, and a new asymptomatic lesion on the right side of the neck. The patient worked as a truck driver and frequently traveled to Wisconsin; he had not traveled internationally in the past year. He lived with his brother who had a pet cat. Read More

Eur J Clin Microbiol Infect Dis 2021 Nov 12;40(11):2407-2410. Epub 2021 Apr 12.

Centre National de Référence des Rickettsies, Coxiella et Bartonella IHU-Méditerranée Infection, APHM, Marseille, France.

We studied retrospectively 651 PCR-confirmed Bartonella infections diagnosed at the French reference center for bartonellosis from 2014 to 2019. The most common form was cat-scratch disease (89%) followed by endocarditis (9%). Disseminated forms (2%) mainly presented as bacillary angiomatosis or peliosis hepatis in solid organ transplant recipients. Read More

Pathogens 2021 Mar 10;10(3). Epub 2021 Mar 10.

Department of Biomedical Sciences, Duluth Campus, Medical School, University of Minnesota, Duluth, MN 55812, USA.

, , and are bacteria known to cause verruga peruana or bacillary angiomatosis, vascular endothelial growth factor (VEGF)-dependent cutaneous lesions in humans. Given the bacteria's association with the dermal niche and clinical suspicion of occult infection by a dermatologist, we determined if patients with melanoma had evidence of spp. infection. Read More

Liver Int 2021 03 29;41(3):621-622. Epub 2020 Nov 29.

Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

Cureus 2020 Sep 27;12(9):e10688. Epub 2020 Sep 27.

Department of Gastroenterology, Istanbul Medeniyet University, School of Medicine, Istanbul, TUR.

HIV is a global epidemic that needs a multidisciplinary approach. Gastrointestinal bleeding is uncommon in HIV-positive patients. In cases such as bacillary angiomatosis, Kaposi sarcoma, herpes simplex, histoplasmosis, and cytomegalovirus (CMV) colitis, the underlying reason could be HIV. Read More

Exp Ther Med 2020 Jul 29;20(1):56-60. Epub 2019 Nov 29.

Department of Dermatology, Derma 360° Clinic, Bucharest 011273, Romania.

Bacillary angiomatosis represents a cutaneous and systemic infection caused by species, typically described in the past in HIV-positive patients or associated with immunodeficiencies. More recent case reports had brought into attention the probability that this entity may manifest in otherwise healthy individuals, triggered by trauma and skin burns. The physiopathology of this neoproliferative process is based on the production of angiogenetic molecules, such as vascular endothelial growth factor (VEGF) and IL-8. Read More

Int J Surg Pathol 2020 Dec 27;28(8):868-871. Epub 2020 May 27.

National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.

Primary effusion lymphoma is a rare, clinically aggressive large B-cell neoplasm universally associated with human herpesvirus 8 that occurs in the setting of immune compromise. It is classically described as a lymphomatous effusion occurring within body cavities. Recently, however, solid tumor masses, and rarely an intravascular form, have been described. Read More

Actas Dermosifiliogr (Engl Ed) 2020 Sep 13;111(7):561-566. Epub 2020 May 13.

Unidad de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario San Cecilio, Granada, España.

Doxycycline is a synthetic tetracycline that was approved in 1967. This wide-spectrum antibiotic has been shown to also have useful anti-inflammatory properties that make it suitable for the treatment of a number of noninfectious conditions. Tetracyclines are probably the most commonly prescribed antibiotics in dermatology, where they are usually used at doses lower than those effective against infections. Read More

Transplant Proc 2020 Oct 23;52(8):2524-2526. Epub 2020 Apr 23.

Department of Dermatology, Jagiellonian University Medical College, Kraków, Poland.

Introduction: Bacillary angiomatosis (BA) is a rare, opportunistic infectious disease caused by the aerobic Gram-negative bacilli Bartonella henselae or Bartonella quintana. The main reservoir for those microbes are cats. The disease mostly affects immunocompromised patients with human immunodeficiency virus infection, after organ transplantation, undergoing corticosteroid and methotrexate therapy or with oncological history. Read More

BMC Infect Dis 2020 Mar 12;20(1):216. Epub 2020 Mar 12.

Division of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of Health, Chungcheongbuk-do, Korea.

Background: Tick-borne lymphadenopathy (TIBOLA) is an infectious disease, mainly caused by species from the spotted fever group rickettsiae and is characterized by enlarged lymph nodes following a tick bite. Among cases of TIBOLA, a case of scalp eschar and neck lymphadenopathy after tick bite (SENLAT) is diagnosed when an eschar is present on the scalp, accompanied by peripheral lymphadenopathy (LAP). Only a few cases of SENLAT caused by Bartonella henselae have been reported. Read More

Inflamm Bowel Dis 2020 02;26(3):e17-e18

Gastroenterology Department, Hospital Universitario Marqués de Valdecilla, Instituto de investigación Sanitaria de Cantabria (IDIVAL), Santander, Spain.

IDCases 2019 31;18:e00649. Epub 2019 Oct 31.

Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Denmark.

An Bras Dermatol 2019 Sep - Oct;94(5):594-602. Epub 2019 Oct 2.

Laboratory of Applied Research in Dermatology and Bartonella Infection, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil; Discipline of Dermatology, Department of Clinical Medicine, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil. Electronic address:

Bartonellosis are diseases caused by any kind of Bartonella species. The infection manifests as asymptomatic bacteremia to potentially fatal disorders. Many species are pathogenic to humans, but three are responsible for most clinical symptoms: Bartonella bacilliformis, Bartonella quintana, and Bartonella henselae. Read More

Br J Dermatol 2019 12 28;181(6):e143. Epub 2019 Jul 28.

Serviço de Dermatologia, Centro Hospitalar Universitário do Porto, Porto, Portugal.

JAAD Case Rep 2019 May 7;5(5):430-432. Epub 2019 May 7.

Department of Dermatology, Consorcio Hospital General Universitario de Valencia, Valencia, Spain.

Am J Dermatopathol 2019 Oct;41(10):750-753

Mycology Service Attending Physician, General Hospital Dr Manuel Gea González, Mexico City, Mexico.

We present the case of an HIV-positive patient who developed polymorphous lesions in which the evidence in the skin biopsy corresponds to the diagnosis of bacillary angiomatosis, and further tests proved the pathological agent involved in this case is not the usual Bartonella species, B. henselae and B. quintana, but B. Read More

Genomics 2020 01 19;112(1):467-471. Epub 2019 Mar 19.

School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690 525, Kerala, India. Electronic address:

Bartonella henselae is a facultative intracellular pathogen that occurs worldwide and is responsible primarily for cat-scratch disease in young people and bacillary angiomatosis in immunocompromised patients. The principal source of genome-level diversity that contributes to B. henselae's host-adaptive features is thought to be horizontal gene transfer events. Read More

Ticks Tick Borne Dis 2019 02 27;10(2):360-364. Epub 2018 Nov 27.

Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University (NCSU), 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address:

The objective of this work was to determine the prevalence of Borrelia and Bartonella species in Ixodes spp. ticks collected from 16 USA states. Genus PCR amplification and sequence analysis of Bartonella and Borrelia 16SsRNA-23SsRNA intergenic regions were performed on DNA extracted from 929 questing adult ticks (671 Ixodes scapularis, 155 Ixodes affinis, and 103 Ixodes pacificus). Read More