J Int Assoc Provid AIDS Care 2017 Jan 1:2325957417702484. Epub 2017 Jan 1.

2 Divisions of General Internal Medicine and Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.

Bacillary angiomatosis (BA) is a rare complication of human immune deficiency virus (HIV) infection in the post-antiretroviral therapy (ART) era, and few cases of BA-associated immune reconstitution inflammatory syndrome (IRIS) have been described. We report the case of a 50-year-old man who presented with mass lesions involving the skin, subcutaneous tissues, muscle, and bone. The diagnosis of Bartonella quintana BA was confirmed by serum polymerase chain reaction. Read More

Anal Chem 2017 Jan 7;89(2):1163-1169. Epub 2016 Dec 7.

Department of Bionano Engineering, Hanyang University , Ansan 426-791, South Korea.

A new class of surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor has been developed for the simultaneous detection of dual DNA markers. The LFA strip in this sensor was composed of two test lines and one control line. SERS nano tags labeled with detection DNA probes were used for quantitative evaluation of dual DNA markers with high sensitivity. Read More

Microb Ecol 2017 Feb 2. Epub 2017 Feb 2.

Microbial Pathogenesis and Host Defense Program, University of California, San Francisco, San Francisco, CA, 94143-0654, USA.

Bartonella henselae is an emerging bacterial pathogen causing cat-scratch disease and potentially fatal bacillary angiomatosis in humans. Bacteremic cats constitute a large reservoir for human infection. Although feline vaccination is a potential strategy to prevent human infection, selection of appropriate B. Read More

An Bras Dermatol 2016 Nov-Dec;91(6):811-814

Universidade Federal do Espírito Santo (UFES) - Vitória (ES), Brazil.

Bacillary angiomatosis is an infection determined by Bartonella henselae and B. quintana, rare and prevalent in patients with acquired immunodeficiency syndrome. We describe a case of a patient with AIDS and TCD4+ cells equal to 9/mm3, showing reddish-violet papular and nodular lesions, disseminated over the skin, most on the back of the right hand and third finger, with osteolysis of the distal phalanx observed by radiography. Read More

JAAD Case Rep 2016 Nov 5;2(6):454-456. Epub 2016 Dec 5.

Department of Dermatology, Rush University, Chicago, Illinois.

J Vet Emerg Crit Care (San Antonio) 2016 Nov 13;26(6):851-857. Epub 2016 Apr 13.

Oradell Animal Hospital, Paramus, NJ, 07652.

Objective: To describe a case of hemoperitonium in a dog with Bartonellosis and peliosis hepatis (PH) lesions that resolved following antimicrobial therapy.

Case Summary: A 3-year-11-month-old 22.5 kg female spayed mixed breed dog presented for progressive lethargy and vomiting. Read More

Pediatr Emerg Care 2016 Nov;32(11):789-791

From the *Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill; †Departments of Emergency Medicine and Pediatric Emergency Medicine; ‡Department of Pediatrics, Pediatric Critical Care, WakeMed Health and Hospitals, Raleigh, NC; and §Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC.

Despite the publication of a number of case reports since the 1950s, physician awareness of the unique relationship between cat scratch disease (CSD) and acute encephalopathy remains limited. This report alerts emergency medicine physicians to include CSD encephalopathy (CSDE) in the differential diagnosis when a previously healthy child presents with status epilepticus. Prompt recognition of this relationship impacts the selection of initial diagnostic studies and antibiotic choices and permits reliable insight into prognosis. Read More

Microbiologyopen 2017 Apr 28;6(2). Epub 2016 Oct 28.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Bartonella henselae is a gram-negative zoonotic bacterium that causes infections in humans including endocarditis and bacillary angiomatosis. B. henselae has been shown to grow as large aggregates and form biofilms in vitro. Read More

Indian J Dermatol Venereol Leprol 2017 Jan-Feb;83(1):99-101

Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Am J Dermatopathol 2016 Nov;38(11):793-801

*Resident, Department of Pathology, Hospital 12 de Octubre, Madrid, Spain; †Dermatologist, Dermatopathologie Friedrichshafen, Friedrichshafen, Germany; ‡Dermatologist, Department of Pathology, Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain; and §Pathologist, Department of Pathology, Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain.

Infectious angiogenesis is the biological response of neoangiogenesis induced by infectious organisms. The authors present 3 exemplary entities which show paradigmatic clinico-pathological settings of infectious angiogenesis: Bacillary angiomatosis, Orf (ecthyma contagiosum), and Kaposi sarcoma. The authors review the literature and elucidate etiopathogenetic pathways leading to the phenomenon of neovascularization stimulated by infectious organisms. Read More

IDCases 2016 4;6:77-78. Epub 2016 Oct 4.

Division of Anatomical Pathology, Stellenbosch University and National Health Laboratory Service, Tygerberg Hospital, Parow, South Africa.

Medicine (Baltimore) 2016 Jul;95(28):e4155

aInstitute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology bDivision of Immunology, Allergy and Infectious Diseases, Department of Dermatology cClinical Institute for Pathology dDepartment of Radiology and Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Background: The clinical manifestation of bacillary angiomatosis (BA) can be limited to one organ, most commonly the skin, but systemic courses can also occur. We report a human immunodeficiency virus (HIV)-positive patient with a systemic manifestation of BA caused by Bartonella quintana, diagnosed in Vienna, Austria. The pathogen was detected in multiple organs including a facial tumor which is an unusual finding for BA. Read More

Lancet Infect Dis 2016 Aug 30;16(8):e164-72. Epub 2016 Jun 30.

Medicine Service, South Texas Veterans Health Care System, San Antonio, TX, USA; Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Electronic address:

In 1915, a British medical officer on the Western Front reported on a soldier with relapsing fever, headache, dizziness, lumbago, and shin pain. Within months, additional cases were described, mostly in frontline troops, and the new disease was called trench fever. More than 1 million troops were infected with trench fever during World War 1, with each affected soldier unfit for duty for more than 60 days. Read More

Rev Esp Salud Publica 2016 May 5;90:E5. Epub 2016 May 5.

Departamento de Patología Animal. Facultad de Veterinaria de Zaragoza. Zaragoza. España.

Objective: Bartonella henselae is responsible for the Cat Scratch Disease in humans, being it underdiagnosed. This study aims to detect and quantify the load of B. henselae DNA in oral and whole blood samples from stray and shelthered cats from Zaragoza (Spain), and analyze associations with epidemiological and clinical factors. Read More

JAAD Case Rep 2016 Jan 4;2(1):77-9. Epub 2016 Feb 4.

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

PLoS Negl Trop Dis 2016 Mar 21;10(3):e0004509. Epub 2016 Mar 21.

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Bacteria from the genus Bartonella are emerging blood-borne bacteria, capable of causing long-lasting infection in marine and terrestrial mammals, including humans. Bartonella are generally well adapted to their main host, causing persistent infection without clinical manifestation. However, these organisms may cause severe disease in natural or accidental hosts. Read More

Tunis Med 2015 Jul;93(7):478-9

Infect Immun 2015 Dec 28;84(3):711-22. Epub 2015 Dec 28.

University Hospital, Goethe-University, Institute for Medical Microbiology and Infection Control, Frankfurt am Main, Germany

Bacterial adherence determines the virulence of many human-pathogenic bacteria. Experimental approaches elucidating this early infection event in greater detail have been performed using mainly methods of cellular microbiology. However, in vitro infections of cell monolayers reflect the in vivo situation only partially, and animal infection models are not available for many human-pathogenic bacteria. Read More

S Afr Med J 2015 Oct;105(10):874

An HIV-positive 39-year-old man presented with generalised nodular lesions. He was apyrexial and normotensive, with a normal respiratory rate. The rest of the examination was normal. Read More

Am J Surg Pathol 2016 Mar;40(3):342-7

Mayo Clinic, Division of Hematopathology, Rochester, MN.

Bartonella henselae lymphadenitis, or cat-scratch lymphadenitis (CSL), is classically associated with stellate microabscesses, occasional giant cells, and extension of the inflammatory infiltrate into perinodal soft tissue. Availability of B. henselae molecular testing on tissue specimens has broadened our understanding of the morphologic variation in this disease. Read More

Indian J Dermatol 2015 Sep-Oct;60(5):523

Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.

Bacillary angiomatosis is an infectious disease caused by two Gram-negative bacilli; this disease usually affects immunosuppressed hosts with a history of cat scratch. We report a rare case of bacillary angiomatosis in an immunocompetent 26-year-old woman with no history of exposure to cats, and with atypical clinical features (very pruritic vascular papules and nodules with ulceration and hemorrhage on the right arm and fingers). She was successfully treated with clarithromycin for 3 months. Read More

Eur J Dermatol 2015 May-Jun;25(3):268-9

Department of Dermatology.

Indian J Sex Transm Dis 2015 Jan-Jun;36(1):92-4

Department of STD, SHIFA Hospitals, Tirunelveli, Tamil Nadu, India.

A 14 year old boy, said to have had multiple transfusions during infancy, was brought to the hospital for complaints of pain over right thigh for one week duration. MRI reveals multiple osteolytic lesions with enhancing hyperintense bone marrow lesions over iliac bones, right acetabulum and lumbar vertebral bodies and enlarged para-aortic, iliac and inguinal lymph nodes. CT of the whole body revealed osteolytic lesions on skull, mandible, right scapula, head of both humeri, L1 and L4 vertebrae, 5(th) and 10(th) ribs, both acetabulum and ala of sacrum along with enlargement of cervical, axillary and mesenteric, iliac and inguinal nodes. Read More

Am J Dermatopathol 2015 Oct;37(10):771-2, 799-800

Division of Dermatology and Cutaneous Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX.

Indian J Dermatol Venereol Leprol 2015 Jul-Aug;81(4):398-400

Department of Dermatology and Venereology, Hospital Garcia de Orta, Almada, Portugal.

Ann Cardiol Angeiol (Paris) 2016 Feb 19;65(1):48-50. Epub 2015 Jan 19.

Service de cardiologie, hôpital d'instruction des armées Desgenettes, 108, boulevard Pinel, 69275 Lyon cedex 03, France.

We report a case of blood culture-negative tricuspid infective endocarditis revealed after tick bite by repeated pulmonary infection during one year due to septic pulmonary emboli in a 67-year-old farmer woman. Tricuspid vegetation and pulmonary emboli are calcified. Lyme serology is negative. Read More

Rev Chilena Infectol 2015 Feb;32 Suppl 1:S57-71

The ongoing human immunodeficiency virus (HIV) infection epidemic coupled with more efficacious and available treatments has led to a larger number of patients living with HIV or AIDS. As a result, skin manifestations related to HIV/AIDS or its therapy have become increasingly more common and are reported to occur in as many as 95% of patients. Herein, we review the most common HIV/AIDS related cutaneous pathologies and classify them into inflammatory, HAART-associated, neoplastic, and infectious manifestations. Read More

Cell Microbiol 2015 Oct 19;17(10):1447-63. Epub 2015 May 19.

Institute for Medical Microbiology and Infection Control, Goethe University, Frankfurt am Main, Germany.

The contribution of myeloid cells to tumour microenvironments is a decisive factor in cancer progression. Tumour-associated macrophages (TAMs) mediate tumour invasion and angiogenesis through matrix remodelling, immune modulation and release of pro-angiogenic cytokines. Nothing is known about how pathogenic bacteria affect myeloid cells in these processes. Read More

Transpl Infect Dis 2015 Jun 1;17(3):411-7. Epub 2015 Jun 1.

Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Bartonella henselae (BH) is the main cause of cat scratch disease (CSD), which more typically presents as a self-limited localized suppurative lymphadenopathy in immunocompetent individuals. In contrast, immunocompromised patients commonly have systemic disease with life-threatening complications. In addition to the angioproliferative lesions, such as bacillary angiomatosis, an increasing number of immune post-infectious complications are being recognized with BH infections, including glomerulonephritis, vasculitis, hemophagocytic syndrome, and neurological problems. Read More

J Clin Microbiol 2015 May 4;53(5):1556-61. Epub 2015 Mar 4.

Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

Bartonella species constitute emerging, vector-borne, intravascular pathogens that produce long-lasting bacteremia in reservoir-adapted (natural host or passive carrier of a microorganism) and opportunistic hosts. With the advent of more sensitive and specific diagnostic tests, there is evolving microbiological evidence supporting concurrent infection with one or more Bartonella spp. in more than one family member; however, the mode(s) of transmission to or among family members remains unclear. Read More

Enferm Infecc Microbiol Clin 2015 Apr 7;33(4):292-3. Epub 2015 Feb 7.

Servicio de Anatomía Patológica, Hospital Universitario 12 de Octubre, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, España.

Transpl Int 2015 May 18;28(5):626-31. Epub 2015 Feb 18.

Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czech Republic.

Bacillary angiomatosis (BA) is a disorder of neovascular proliferation involving skin and other organs of immunosuppressed patients caused by Bartonella species. BA has been recognized in both immunocompetent and immunodeficient patients, mostly in human immunodeficiency virus (HIV)-infected persons, much more rare in those with other immunodeficiencies, including organ transplantation. Diagnosis is based on serologic analysis, culture and molecular biology [detection of Bartonella species deoxyribonucleic acid (DNA) in tissue biopsy extracts by real-time polymerase chain reaction (PCR)]. Read More

Parasitol Res 2015 Mar 14;114(3):1045-50. Epub 2015 Jan 14.

INP Ecole Nationale Vétérinaire, Toulouse, France.

Bartonella henselae is the causative agent of cat scratch disease in humans, which is recognized as an emerging zoonotic disease. Ctenocephalides felis is the main vector, and transmission of B. henselae infection between cats and humans occurs mainly through infected flea feces. Read More

Acta Dermatovenerol Croat 2014 ;22(4):294-7

Leonor Neto Lopes, MD , Avenida Prof. Egas Moniz, 1649-028 , Lisboa, Portugal;

Bacillary angiomatosis is a systemic disease caused by Bartonella (B.) henselae and B. quintana. Read More

PLoS Negl Trop Dis 2014 Dec 11;8(12):e3385. Epub 2014 Dec 11.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic; Centre for Tropical Medicine and Global Health, Churchill Hospital, University of Oxford, United Kingdom.

Background: Both endocarditis and Bartonella infections are neglected public health problems, especially in rural Asia. Bartonella endocarditis has been described from wealthier countries in Asia, Japan, Korea, Thailand and India but there are no reports from poorer countries, such as the Lao PDR (Laos), probably because people have neglected to look.

Methodology/principal Findings: We conducted a retrospective (2006-2012), and subsequent prospective study (2012-2013), at Mahosot Hospital, Vientiane, Laos, through liaison between the microbiology laboratory and the wards. Read More

Can Vet J 2014 Oct;55(10):970-4

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-7060, USA (MD Tucker, Sellon, RL Tucker); IDEXX Reference Laboratories Inc., Pullman, Washington, USA (Wills); Dillon Small Animal Hospital, Dillon, Montana, USA (Simonsen); Intracellular Pathogens Research Laboratory, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Maggi, Breitschwerdt).

This report describes a 2-year-old collie dog with pulmonary nodules, visualized by computed tomographic (CT) scan, with evidence of Bartonella henselae bacteremia and pyogranulomatous lymphadenitis. Clinical signs resolved with antimicrobial therapy. Read More

Vet Dermatol 2015 Feb 8;26(1):60-3, e21-2. Epub 2014 Oct 8.

Dermatology/Allergy, Veterinary Referral Center of Colorado, Englewood, CO, 80110, USA.

Background: Bartonella henselae, a Gram-negative, zoonotic Alphaproteobacteria that infects erythrocytes, endothelial cells and dendritic cells, has previously been implicated as a cause of panniculitis in dogs and a human.

Animal And Owner: An 8-year-old, spayed female Labrador retriever and its 78-year-old male owner living in the same household.

Methods And Results: When preliminary and advanced testing failed to identify the cause of near-simultaneous-onset dermatological lesions, Bartonella serology, Bartonella Alphaproteobacteria growth medium (BAPGM) enrichment blood culture/PCR and immunohistochemistry were used to test specimens from the dog and owner. Read More

Am J Trop Med Hyg 2014 Sep;91(3):439

Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru; Departamento de Enfermedades Infecciosas Tropicales y Dermatologicas, Hospital Nacional Cayetano Heredia, Lima, Peru

JAMA Dermatol 2014 Sep;150(9):1015-6

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia.

J Hand Surg Am 2014 Aug;39(8):1636-45

Department of Surgery, King Saud University, Riyadh, Saudi Arabia; Medical College of Al-Faisal University, Riyadh, Saudi Arabia.

Chronic infections of the hand are uncommon, and a high index of suspension is required for their early diagnosis. These can be grouped based on the microorganism. Mycobacterial infections include tuberculosis, atypical mycobacterial infections, and leprosy. Read More

Emerg Infect Dis 2014 Aug;20(8):1396-7

Mikrobiyol Bul 2014 Jul;48(3):477-83

Adnan Menderes University Faculty of Medicine, Department of Medical Microbiology, Aydin, Turkey.

Bartonella species cause several diseases in humans such as cat stratch disease, bacillary angiomatosis, peliosis hepatis, endocarditis, Carrion disease and trench fever. Cat scratch disease and bacillary angiomatosis cases have already been reported in Turkey. Studies from our region, namely Aydin (a province located at Western Anatolia, Turkey) indicated that mean Bartonella henselae IgG seropositivity rate is 11. Read More

Zebrafish 2014 Oct 15;11(5):434-46. Epub 2014 Jul 15.

1 Department of Molecular Medicine, University of South Florida Morsani College of Medicine , Tampa, Florida.

Bartonella henselae (Bh) is an emerging zoonotic pathogen that has been associated with a variety of human diseases, including bacillary angiomatosis that is characterized by vasoproliferative tumor-like lesions on the skin of some immunosuppressed individuals. The study of Bh pathogenesis has been limited to in vitro cell culture systems due to the lack of an animal model. Therefore, we wanted to investigate whether the zebrafish embryo could be used to model human infection with Bh. Read More

Int J Antimicrob Agents 2014 Jul 9;44(1):16-25. Epub 2014 May 9.

URMITE UMR 6236, CNRS-IRD, Faculté de Médecine Aix Marseille Universite, 27 Bd. Jean Moulin, 13385 Marseille cedex 05, France. Electronic address:

Bartonella spp. are responsible for emerging and re-emerging diseases around the world. The majority of human infections are caused by Bartonella henselae, Bartonella quintana and Bartonella bacilliformis, although other Bartonella spp. Read More

Pediatr Dev Pathol 2014 Jul-Aug;17(4):312-20. Epub 2014 Jun 4.

1  Department of Pathology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

We report a case of a 21-year-old young man with underlying congenital heart disease who developed Bartonella henselae endocarditis of the right ventricular outflow tract (RVOT) conduit of his Melody transcatheter (percutaneous) pulmonary valve (TPV), with an initial presentation of glomerulonephritis with a dominant C3 pattern, with renal failure and circulating cryoglobulins. There are few reports of a glomerulonephritis with a dominant C3 pattern presenting as a manifestation of B. henselae endocarditis. Read More

J Vet Intern Med 2014 Jul-Aug;28(4):1341-5. Epub 2014 May 9.

Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, New Bolton Center, Kennett Square, PA.

Emerg Infect Dis 2014 May;20(5):907-8

J Int Assoc Provid AIDS Care 2015 Jan-Feb;14(1):21-5. Epub 2014 Apr 9.

Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA

Background: Bacillary angiomatosis (BA) is a rare manifestation of infection caused by Bartonella species, which leads to vasoproliferative lesions of skin and other organs. Bacillary angiomatosis affects individuals with advanced HIV disease or other immunocompromised individuals. In sub-Saharan Africa, despite the high prevalence of HIV infection and documentation of the causative Bartonella species in humans, mammalian hosts, and arthropod vectors, BA has only rarely been described. Read More

Dermatol Online J 2014 Mar 17;20(3). Epub 2014 Mar 17.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Angiolymphoid hyperplasia with eosinophilia is an uncommon, benign hyperproliferative disorder. Papules and nodules occur predominantly in the head and neck region. Involvement of other sites such as the trunk and mucosae has been rarely reported. Read More

J Cutan Pathol 2014 Mar;41(3):277-80

Des Moines University, IA, USA.