4,574 results match your criteria Babesiosis


International survey on the impact of parasitic infections: frequency of transmission and current mitigation strategies.

Vox Sang 2018 Dec 6. Epub 2018 Dec 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background And Objectives: Globally, blood safety interventions have been successful in mitigating risk of the major transfusion-transmitted (TT) viruses. However, strategies that address risk from parasites are comparatively limited. TT parasites are often regional in nature, posing unique challenges; we sought to understand their impact on blood safety. Read More

View Article
December 2018
1 Read

Babesiosis-Associated Splenic Rupture: Case Series from a Hyperendemic Region.

Clin Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University.

Background: Spontaneous splenic rupture is an increasingly reported complication of babesiosis and has been described as a severe complication.

Methods: We performed a retrospective chart review in a high prevalence area to identify seven cases of babesiosis-related splenic rupture between 2014 - 2016.

Results: Splenic rupture occurred in approximately 1% of babesiosis cases. Read More

View Article
December 2018

Endochin-Like Quinolones Exhibit Promising Efficacy Against and in Experimentally Infected Pregnant Mice.

Front Vet Sci 2018 19;5:285. Epub 2018 Nov 19.

Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.

We report on the efficacy of selected endochin-like quinolones (ELQs) against tachyzoites grown in human foreskin fibroblasts (HFF), and in a pregnant BALB/c mouse model. Fourteen ELQs were screened against transgenic tachyzoites expressing β-galactosidase (Nc-βgal). Drugs were added concomitantly to infection and the values for 50% proliferation inhibition (IC) were determined after 3 days. Read More

View Article
November 2018

The impact of Babesia microti blood donation screening.

Transfusion 2018 Nov 30. Epub 2018 Nov 30.

Scientific Affairs, American Red Cross Holland Laboratory, Rockville, Maryland.

Background: Babesia microti, an intraerythrocytic parasite endemic in the Northeast and upper Midwest United States, is responsible for over 200 reported cases of transfusion-transmitted babesiosis (TTB). The American Red Cross has prospectively screened donations in endemic areas for B. microti since 2012. Read More

View Article
November 2018
2 Reads

Multistate Infestation with the Exotic Disease-Vector Tick Haemaphysalis longicornis - United States, August 2017-September 2018.

MMWR Morb Mortal Wkly Rep 2018 Nov 30;67(47):1310-1313. Epub 2018 Nov 30.

Haemaphysalis longicornis is a tick indigenous to eastern Asia and an important vector of human and animal disease agents, resulting in such outcomes as human hemorrhagic fever and reduction of production in dairy cattle by 25%. H. longicornis was discovered on a sheep in New Jersey in August 2017 (1). Read More

View Article
November 2018
3 Reads

LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study.

PLoS One 2018 28;13(11):e0207245. Epub 2018 Nov 28.

ERA Chair"VetMedZg", Clinic for Internal diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb, Croatia.

Phosphorylation is the most commonly studied protein post-translational modification (PTM) in biological systems due to its importance in controlling cell division, survival, growth, etc. Despite the thorough research in phosphoproteomics of cells and tissues there is little information on circulating phosphoproteins. We compared serum from 10 healthy dogs and 10 dogs affected by B. Read More

View Article
November 2018

Babesia gibsoni endemic to Wuhan, China: mitochondrial genome sequencing, annotation, and comparison with apicomplexan parasites.

Parasitol Res 2018 Nov 24. Epub 2018 Nov 24.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.

Babesia gibsoni (B. gibsoni), an intracellular apicomplexan protozoan, poses great threat to canine health. Currently, little information is available about the B. Read More

View Article
November 2018
2 Reads

in three imported dogs: a new tickborne disease reaching the United Kingdom.

Vet Rec 2018 Dec 21;183(23):716. Epub 2018 Nov 21.

Diagnostic Laboratories, Langford Vets, Bristol Veterinary School, University of Bristol, Langford, UK.

An increasing number of non-endemic vectorborne pathogens have been described in dogs imported to the UK in the past two decades. Recently, an outbreak of canine babesiosis in south-east England has raised veterinary awareness with regard to the impact of such diseases on the UK canine population. Canine hepatozoonosis, caused by and transmitted by the ingestion of ticks, is widespread in the Mediterranean basin. Read More

View Article
December 2018
2 Reads

Establishment of a continuous culture of in human erythrocytes reveals unusually high tolerance to recommended therapies.

J Biol Chem 2018 Nov 21. Epub 2018 Nov 21.

Medicine, Yale University School of Medicine, United States.

Human babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the genus Clinical cases caused by have been associated with high parasite burden, severe pathology and death. In both mice and hamsters, the parasite causes uncontrolled fulminant infections, which ultimately lead to death. Resolving these infections requires knowledge of biology, virulence, and susceptibility to anti-infectives, but little is known and further research is hindered by a lack of relevant model systems. Read More

View Article
November 2018
3 Reads
4.570 Impact Factor

Molecular identification of Babesia spp isolated from Polish cattle with asymptomatic protozoa infections.

Pol J Vet Sci 2018 Jun;21(2):287-291

Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences Lublin, Głęboka 30, 20-612 Lublin, Poland.

The aim of the paper was to study the epizootic situation of babesiosis in the cattle population in eastern Poland and possibly to determine what species of protozoa infects Polish cattle. Blood samples for molecular analysis (real time PCR) were collected from 192 dairy cows from various farms located in eastern Poland. The infection was detected in 10. Read More

View Article
June 2018
1 Read

Optimizing exchange transfusion for patients with severe Babesia divergens babesiosis: Therapeutically-Rational Exchange (T-REX) of M antigen-negative and/or S antigen-negative red blood cells should be evaluated now.

Transfus Clin Biol 2018 Oct 19. Epub 2018 Oct 19.

Biconcavity Inc., Lilburn, GA, USA; Retired USPHS Commissioned Corps, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Babesia divergens is an intraerythrocytic parasite, which is the major cause of babesiosis in Europe. For years, clinicians have been publishing stunning case reports that describe how some - but not all - conventional red blood cell (RBC) exchange transfusions have saved the lives of severely ill babesiosis patients. Due to markedly different patient outcomes, clinicians agree that new treatments and additional studies are needed. Read More

View Article
October 2018
3 Reads

To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia.

Int J Parasitol 2018 Nov 1. Epub 2018 Nov 1.

Harvard T. H. Chan School of Public Health, 651 Huntington Ave, Boston, MA 02115, USA. Electronic address:

Babesia parasites infect a diverse range of vertebrate hosts, from penguins to pigs. Recently, the emergence of zoonotic Babesia infection has been increasing, and the list of species reported to infect humans continues to grow. Babesiosis represents a burgeoning veterinary and medical threat, and the need for novel therapeutic drugs to effectively target this diverse group of parasites is pressing. Read More

View Article
November 2018
5 Reads

Analysis of the Babesia microti proteome in infected red blood cells by a combination of nanotechnology and mass spectrometry.

Int J Parasitol 2018 Nov 1. Epub 2018 Nov 1.

Protistology Laboratory, American Type Culture Collection, Manassas, VA 20110, USA. Electronic address:

Proteomics of Babesia microti has lagged behind other apicomplexans despite recent genome and transcriptome studies. Here, we used a combination of nanotechnology and mass spectrometry to provide a proteomic profile of B. microti acute infection. Read More

View Article
November 2018

Babesia bovis RON2 contains conserved B-cell epitopes that induce an invasion-blocking humoral immune response in immunized cattle.

Parasit Vectors 2018 Nov 3;11(1):575. Epub 2018 Nov 3.

Immunology and Vaccines Laboratory, C. A. Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Carretera a Chichimequillas, Ejido Bolaños, 76140, Queretaro, Queretaro, Mexico.

Background: Babesia bovis belongs to the phylum Apicomplexa and is the major causal agent of bovine babesiosis, the most important veterinary disease transmitted by arthropods. In apicomplexan parasites, the interaction between AMA1 and RON2 is necessary for the invasion process, and it is a target for vaccine development. In B. Read More

View Article
November 2018

High seroprevalence of Babesia antibodies among Borrelia burgdorferi-infected humans in Sweden.

Ticks Tick Borne Dis 2019 Jan 28;10(1):186-190. Epub 2018 Oct 28.

Department of Laboratory Medicine, Lund University, Skåne University Hospital, Lund, Sweden. Electronic address:

In northern Europe, tick-borne diseases such as Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are well known. The actual incidence of Babesia infections, however, has remained elusive. In this study, the prevalence of antibodies against two Babesia spp. Read More

View Article
January 2019
1 Read

Transfusion-Transmitted Babesiosis.

Arch Pathol Lab Med 2018 Oct 30. Epub 2018 Oct 30.

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Babesiosis is most commonly caused by Babesia microti and is transmitted via the bite of an infected Ixodes spp tick. However, Babesia is also transmitted via blood transfusion. In the United States, the first case of transfusion-transmitted babesiosis was recognized in 1979, and in recent years, the incidence has rapidly increased. Read More

View Article
October 2018
1 Read

A library of recombinant Babesia microti cell surface and secreted proteins for diagnostics discovery and reverse vaccinology.

Int J Parasitol 2018 Oct 24. Epub 2018 Oct 24.

Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom. Electronic address:

Human babesiosis is an emerging tick-borne parasitic disease and blood transfusion-transmitted infection primarily caused by the apicomplexan parasite, Babesia microti. There is no licensed vaccine for B. microti and the development of a reliable serological screening test would contribute to ensuring the safety of the donated blood supply. Read More

View Article
October 2018
6 Reads

Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease.

Int J Parasitol 2018 Oct 24. Epub 2018 Oct 24.

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA. Electronic address:

The incidence of babesiosis, Lyme disease and other tick-borne diseases has increased steadily in Europe and North America during the last five decades. Babesia microti is transmitted by species of Ixodes, the same ticks that transmit the Lyme disease-causing spirochete, Borrelia burgdorferi. B. Read More

View Article
October 2018
1 Read

Evidence for transmission of the zoonotic apicomplexan parasite Babesia duncani by the tick Dermacentor albipictus.

Int J Parasitol 2018 Oct 25. Epub 2018 Oct 25.

California Department of Public Health, Vector-Borne Disease Section, Sacramento, CA 95899, USA.

Babesiosis is a potentially fatal tick-borne zoonotic disease caused by a species complex of blood parasites that can infect a variety of vertebrates, particularly dogs, cattle, and humans. In the United States, human babesiosis is caused by two distinct parasites, Babesia microti and Babesia duncani. The enzootic cycle of B. Read More

View Article
October 2018
1 Read

Comparative evaluation of DNA extraction kit, matrix sample and qPCR assays for bovine babesiosis monitoring.

Mol Biol Rep 2018 Oct 25. Epub 2018 Oct 25.

Embrapa Pecuária Sudeste, Rodovia Washington Luiz, Km 234, Fazenda Canchim, São Carlos, SP, 13560-970, Brazil.

Bovine babesiosis caused by protozoan parasites Babesia bovis and B. bigemina is one of the most important causes of losses for the livestock industry in tropical and subtropical regions of the world. Therefore, highly sensitive and specific tools for these hemoparasites detection and monitoring are required, especially in carrier animals, in which low parasite levels were usually present. Read More

View Article
October 2018
8 Reads

MOLECULAR DETECTION OF BABESIA ODOCOILEI IN WILD, FARMED, AND ZOO CERVIDS IN ONTARIO, CANADA.

J Wildl Dis 2018 Oct 19. Epub 2018 Oct 19.

1   Ontario Veterinary College, University of Guelph, 50 Stone Rd. E., Guelph, Ontario N1G 2W1, Canada.

Babesia odocoilei, a tick-borne protozoan hemoparasite of white-tailed deer ( Odocoileus virginianus), is being increasingly recognized as a cause of disease in captive cervids in North America. Historically endemic in white-tailed deer, the natural wildlife reservoir in the southeastern US, B. odocoilei has been recently associated with hemolytic anemia in captive Eurasian tundra reindeer ( Rangifer tarandus tarandus), wapiti ( Cervus canadensis), and woodland caribou ( Rangifer tarandus caribou) in the northcentral and northeastern US and several Canadian provinces. Read More

View Article
October 2018
12 Reads

Human Babesiosis, Yucatán State, Mexico, 2015.

Emerg Infect Dis 2018 Nov;24(11):2061-2062

In 2015, we detected clinical cases of babesiosis caused by Babesia microti in Yucatán State, Mexico. Cases occurred in 4 children from a small town who became ill during the same month. Diagnosis was confirmed using conventional PCR followed by sequencing of the DNA fragment obtained. Read More

View Article
November 2018
5 Reads

Current Status of Tick-Borne Diseases in South Korea.

Vector Borne Zoonotic Dis 2018 Oct 17. Epub 2018 Oct 17.

1 Department of Internal Medicine and Inha University School of Medicine , Incheon, Republic of Korea.

Background: Bites with tick-borne pathogens can cause various bacterial, viral, or parasitic diseases in humans. Tick-transmitted diseases are known as contributing factors to the increasing incidence and burden of diseases. The present article investigated the epidemiology of tick-borne diseases in South Korea. Read More

View Article
October 2018
2 Reads

Prevalence of canine Babesia and Ehrlichia co-infection and the predictive value of haematology.

Onderstepoort J Vet Res 2018 Oct 9;85(1):e1-e5. Epub 2018 Oct 9.

Department of Companion Animal Clinical Studies, University of Pretoria.

Canine babesiosis and ehrlichiosis are important tick-borne infections in South Africa. Many South African general veterinary practitioners perceive co-infection with Ehrlichia spp. as a common occurrence in dogs with babesiosis. Read More

View Article
October 2018
4 Reads

Babesia gibsoni cytochrome b mutations in canine blood samples submitted to a US veterinary diagnostic laboratory.

J Vet Intern Med 2018 Nov 11;32(6):1965-1969. Epub 2018 Oct 11.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

Background: Babesiosis caused by Babesia gibsoni is recognized throughout the world and can be difficult to treat. Resistance to atovaquone is associated with mutations in the B. gibsoni mitochondrial genome, specifically the M128 position of cytochrome b (cytb). Read More

View Article
November 2018
1 Read

Detection of Babesia gibsoni in dogs by combining recombinase polymerase amplification (RPA) with lateral flow (LF) dipstick.

Parasitol Res 2018 Dec 6;117(12):3945-3951. Epub 2018 Oct 6.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, People's Republic of China.

Babesia gibsoni is a protozoan parasite responsible for the majority of reported cases of canine babesiosis in China. Currently, microscopic examination of the Giemsa-stained thin blood smears is the main diagnosis method in clinic. Here, we report the recombinase polymerase amplification-lateral flow (LF-RPA) dipstick detection method for targeting B. Read More

View Article
December 2018
7 Reads

Genetic diversity and prevalence of piroplasm species in equids from Turkey.

Comp Immunol Microbiol Infect Dis 2018 Aug 12;59:47-51. Epub 2018 Sep 12.

Department of Parasitology, College of Veterinary Medicine, Firat University, 23119, Elazig, Turkey.

Equine piroplasmosis (EP) is a protozoon disease caused by Babesia caballi and Theileria equi transmitted by ticks from the Ixodidae family. This study investigated the genetic heterogeneity and diversity of piroplasm genotypes using the Reverse Line Blotting (RLB) technique for piroplasm species in equids in Turkey. A total of 233 blood samples from 142 horses and 91 donkeys were collected in Şanlıurfa, Tunceli, and Iğdır. Read More

View Article
August 2018
1 Read

Vectors of Babesiosis.

Annu Rev Entomol 2018 Oct 1. Epub 2018 Oct 1.

UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland; email:

Babesiosis, caused by piroplasmid protozoans in the genus Babesia, is arguably the most important vector-borne disease of livestock and companion animals and is growing in importance as a zoonosis. Ixodid ticks were identified as vectors more than a hundred years ago, but the particular tick species transmitting some significant pathogens are still unknown. Moreover, it is only recently that the complexity of the pathogen-tick relationship has been revealed as a result of studies enabled by gene expression and RNA interference methodology. Read More

View Article
October 2018
5 Reads

Diagnosis of a tick-borne coinfection in a patient with persistent symptoms following treatment for Lyme disease.

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

A 67-year-old woman presented with 5 days of myalgias and fevers on completion of a 21-day course of amoxicillin for Lyme disease ( infection). She was found to have profound thrombocytopenia, as well as new anaemia and leucopenia. Workup revealed as the causative agent of her symptoms. Read More

View Article
September 2018
5 Reads

Transfusion-transmitted babesiosis: one state's experience.

Transfusion 2018 Nov 27;58(11):2611-2616. Epub 2018 Sep 27.

Massachusetts Department of Public Health, Bureau of Infectious Disease and Laboratory Sciences, Boston, Massachusetts.

Background: The risk for tickborne exposure to Babesia microti infection exists statewide in Massachusetts. Broad exposure complicates investigations of transfusion-transmitted babesiosis (TTB). We summarize 8 years of the epidemiology of TTB and highlight the role of public health in prevention and control. Read More

View Article
November 2018
2 Reads

Unusual Complications From Babesia Infection: Splenic Infarction and Splenic Rupture in Two Separate Patients.

J Emerg Med 2018 Nov 22;55(5):e113-e117. Epub 2018 Sep 22.

Department of Emergency Medicine, Alpert School of Medicine, Brown University, Providence, Rhode Island.

Background: Babesiosis is a zoonotic parasitic infection transmitted by the tick, Ixodes scapularis. Splenic infarct and rupture are infrequent complications of Babesia parasitemia, and have not been previously reported in the emergency medicine literature.

Case Report: We present two separate cases seen within 1 month at our institution: a case of splenic rupture and another case of splenic infarction due to Babesia parasitemia. Read More

View Article
November 2018
15 Reads

An 85-Year-Old Man With Recurrent Fever and Multiple Splenic Infarcts.

Infect Dis Clin Pract (Baltim Md) 2018 Sep 21;26(5):300-302. Epub 2018 Apr 21.

Division of Infectious Diseases, Department of Medicine, Maimonides Medical Center, Brooklyn, NY.

View Article
September 2018

Clinical, morphological, and molecular characterization of an undetermined Babesia species in a maned wolf (Chrysocyon brachyurus).

Ticks Tick Borne Dis 2019 Jan 11;10(1):124-126. Epub 2018 Sep 11.

Diagnostic Medicine/Pathobiology, College of Veterinary Medircine, Kansas State University, 1800 Denison Ave., Manhattan, KS 66506, USA. Electronic address:

A possible novel Babesia species infection of a maned wolf (Chrysocyon brachyurus) was first reported in 2012. The current case details a confirmed report of a maned wolf with infection by an undetermined species of Babesia. As the mortality and morbidity of babesiosis is high, this may become a significant concern to captive maned wolves, which are considered a near-threatened species by the World Association of Zoos and Aquariums. Read More

View Article
January 2019
1 Read

Variable clinical presentations of babesiosis.

Nurse Pract 2018 Oct;43(10):48-54

Pamela Paparone is an NP at the Atlantic County Health Department, Northfield, N.J. Philip W. Paparone is a communicable disease physician at the Atlantic County Health Department, Northfield, N.J.

Human babesiosis continues to spread in multiple regions of the US. It is transmitted by Ixodes species ticks, as are Lyme disease and anaplasmosis. Its variable clinical presentations, together with serologic detection limitations, require that a high index of clinical suspicion be present for prompt diagnosis. Read More

View Article
October 2018
6 Reads

Molecular surveillance and phylogenetic traits of Babesia bigemina and Babesia bovis in cattle (Bos taurus) and water buffaloes (Bubalus bubalis) from Colombia.

Parasit Vectors 2018 Sep 12;11(1):510. Epub 2018 Sep 12.

Grupo BCEI, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.

Background: Babesia bigemina and B. bovis are two economically important hemoparasites affecting both cattle and buffaloes involved in dairy and beef production. In Colombia, although some parasitological and serological studies suggest an endemicity of these pathogens in areas under 1000 m, little is known about its molecular prevalence in different host. Read More

View Article
September 2018

Renal azotemia and associated clinical and laboratory findings in dogs with Babesia rossi infection.

Vet Parasitol 2018 Aug 29;260:22-29. Epub 2018 Jul 29.

Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria, Onderstepoort 0110, South Africa.

The occurrence of acute kidney injury in canine babesiosis is not well documented. Furthermore, interpretation of urine specific gravity (USG) to assess renal concentrating ability is hampered by the frequent presence of hemoglobinuria in this disease. This cross-sectional study aimed to test the hypothesis that renal azotemia (RA) is underdiagnosed according to current canine babesiosis literature by determining its occurrence at presentation, using urine osmolality instead of USG to measure urinary concentration. Read More

View Article
August 2018
15 Reads

Retrospective study of epidemiological, clinical and pathological findings of bovine babesiosis in Mato Grosso do Sul, Brazil (1995 -2017).

Ticks Tick Borne Dis 2019 Jan 29;10(1):36-42. Epub 2018 Aug 29.

Veterinary Anatomic Pathology Laboratory, FAMEZ, UFMS, Campo Grande, MS, Brazil.

Babesiosis is a tick-borne hemolytic disease caused by intraerythrocytic protozoan parasites of the genus Babesia. The present study describes epidemiological, clinical, and pathological features of cases of bovine babesiosis diagnosed over the last two decades in the state of Mato Grosso do Sul in central-western Brazil. Examination of a total of 5298 bovine samples resulted in a definitive or presumptive diagnosis of babesiosis in 41 cases from 33 outbreaks. Read More

View Article
January 2019
12 Reads

Assessing the risk of Babesia to the United States blood supply using a risk-based decision-making approach: Report of AABB's Ad Hoc Babesia Policy Working Group (original report).

Transfusion 2018 Aug 4;58(8):1916-1923. Epub 2018 Sep 4.

Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Recognizing the increasing threat of transfusion-transmitted babesiosis to the US blood supply, the AABB Board of Directors tasked an Ad Hoc Babesia Policy Working Group (the Working Group) to use the Alliance of Blood Operators' risk-based decision-making (RBDM) framework to assess the risks and benefits of introducing Babesia donation testing in the United States. The regional nature of the Babesia microti risk added complexity to the RBDM assessment because of the unique operational and financial considerations for operators and hospitals located in endemic states. Therefore, the assessment considered safety, product availability, sector sustainability, and technology availability. Read More

View Article
August 2018
13 Reads

Beware of babesiosis: A rare and severe case causing death.

Am J Emerg Med 2018 Dec 27;36(12):2337.e1-2337.e2. Epub 2018 Aug 27.

Crozer-Chester Medical Center, 1 Medical Center Boulevard, Upland, PA 19013, USA. Electronic address:

Babesiosis is an infectious disease caused by protozoa of the genus Babesia which is primarily transmitted by tick vectors. Most cases are asymptomatic or only mild to moderate, but some cases may be severe causing death. A 57 year old male with no reported travel outside the country was escorted by Emergency Medical Services to our Pennsylvania hospital in July of 2018 presenting with hypoglycemia, jaundice, and hypotension. Read More

View Article
December 2018
6 Reads

Insights into the evolution and drug susceptibility of Babesia duncani from the sequence of its mitochondrial and apicoplast genomes.

Int J Parasitol 2018 Aug 31. Epub 2018 Aug 31.

Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

Babesia microti and Babesia duncani are the main causative agents of human babesiosis in the United States. While significant knowledge about B. microti has been gained over the past few years, nothing is known about B. Read More

View Article
August 2018
2 Reads
3.872 Impact Factor

Impact of Wearing and Washing/Drying of Permethrin-Treated Clothing on Their Contact Irritancy and Toxicity for Nymphal Ixodes scapularis (Acari: Ixodidae) Ticks.

J Med Entomol 2018 Aug 27. Epub 2018 Aug 27.

Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO.

Permethrin-treated clothing is available as consumer products to prevent bites by tick and insect pests. We used bioassays to examine the impact of wearing and washing/drying of permethrin-treated shirts, pants, and socks, and wearing of treated shoes, on their contact irritancy and toxicity for nymphal Ixodes scapularis Say (Acari: Ixodidae) ticks, the primary vectors in the eastern United States of the causative agents of Lyme disease, human anaplasmosis, and human babesiosis. Pristine permethrin-treated clothing displayed strong contact irritancy and toxicity toward I. Read More

View Article
August 2018
2 Reads

Genetic Analysis of Babesia Isolates from Cattle with Clinical Babesiosis in Sri Lanka.

J Clin Microbiol 2018 Nov 25;56(11). Epub 2018 Oct 25.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan

Bovine babesiosis is a serious threat to the cattle industry. We prepared blood DNA samples from 13 cattle with clinical babesiosis from the Badulla ( = 8), Jaffna ( = 3), and Kilinochchi ( = 2) districts in Sri Lanka. These DNA samples tested positive in PCR assays specific for ( = 9), ( = 9), and ( = 1). Read More

View Article
November 2018
8 Reads
3.993 Impact Factor

Identification of a putative methyltransferase gene of Babesia bigemina as a novel molecular biomarker uniquely expressed in parasite tick stages.

Parasit Vectors 2018 Aug 24;11(1):480. Epub 2018 Aug 24.

Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, 99164, USA.

Background: Bovine babesiosis is caused by apicomplexan pathogens of the genus Babesia such as B. bigemina and B. bovis. Read More

View Article
August 2018
2 Reads

Detection of Babesia occultans protozoa in cattle from territory of eastern Poland.

Tierarztl Prax Ausg G Grosstiere Nutztiere 2018 Aug 24;46(4):257-259. Epub 2018 Aug 24.

Objective: Bovine piroplasmoses are tick-borne protozoan diseases caused by parasites of the genus and . The aim of this work was to study the epizootic situation of babesiosis in the cattle population in eastern Poland and possibly to determine which species of protozoa infects Polish cattle.

Material, Methods And Results: Blood samples for molecular analysis (real time PCR) were collected from 192 dairy cattle from various farms located in eastern Poland. Read More

View Article
August 2018
11 Reads

Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015: a response to why and what to do.

Transfusion 2018 Jul;58(7):1818

Scientific Affairs, American Red Cross, Gaithersburg, MD.

View Article
July 2018
13 Reads

Response to "Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015: a response to why and what to do".

Transfusion 2018 Jul;58(7):1818-1819

Yale School of Public Health, Yale School of Medicine, New Haven, CT.

View Article
July 2018
6 Reads

Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis.

ACS Infect Dis 2018 Nov 30;4(11):1574-1584. Epub 2018 Aug 30.

VA Portland Health Care System Research and Development Service , 3710 SW US Veterans Hospital Road , Portland , Oregon 97239 , United States.

Cytochrome bc inhibitors have been broadly studied as human and veterinary medicines and agricultural fungicides. For the most part, cytochrome bc inhibitors compete with ubiquinol at the ubiquinol oxidation (Qo) site or with ubiquinone at the quinone reduction (Qi) site. 4(1 H)-Quinolones with 3-position substituents may inhibit either site based on quinolone ring substituents. Read More

View Article
November 2018
25 Reads

Tick-Borne Illnesses in the United States.

Prim Care 2018 Sep 9;45(3):379-391. Epub 2018 Jul 9.

Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL 32224, USA.

Close interaction with nature can lead to tick-borne illnesses, which are seen most frequently in primary care clinics when patients present symptoms. Considerable morbidity can result from untreated infections. Fortunately, these illnesses are often easily managed when diagnosed early. Read More

View Article
September 2018
18 Reads

Validation of Babesia proteasome as a drug target.

Int J Parasitol Drugs Drug Resist 2018 Dec 7;8(3):394-402. Epub 2018 Aug 7.

Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, CZ-370 05, Ceske Budejovice, Czech Republic. Electronic address:

Babesiosis is a tick-transmitted zoonosis caused by apicomplexan parasites of the genus Babesia. Treatment of this emerging malaria-related disease has relied on antimalarial drugs and antibiotics. The proteasome of Plasmodium, the causative agent of malaria, has recently been validated as a target for anti-malarial drug development and therefore, in this study, we investigated the effect of epoxyketone (carfilzomib, ONX-0914 and epoxomicin) and boronic acid (bortezomib and ixazomib) proteasome inhibitors on the growth and survival of Babesia. Read More

View Article
December 2018
7 Reads