4,614 results match your criteria Babesiosis


Human Babesiosis in China: a systematic review.

Parasitol Res 2019 Feb 15. Epub 2019 Feb 15.

Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, National Demonstration Center for Experimental Basic Medical Science Education, Xuzhou Medical University, 221004, Xuzhou, People's Republic of China.

Human babesiosis, a worldwide emerging tick-borne disease, is caused by the intraerythrocytic apicomplexan parasite, babesia. In recent years, the number of infected patients globally has continued to rise, and thus human babesiosis poses a significant public health threat. Therefore, stronger initiatives should be undertaken to prevent further spread and development of this disease. Read More

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http://dx.doi.org/10.1007/s00436-019-06250-9DOI Listing
February 2019

Human Tick-Borne Diseases in Australia.

Front Cell Infect Microbiol 2019 28;9. Epub 2019 Jan 28.

Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

There are 17 human-biting ticks known in Australia. The bites of , and can cause paralysis, inflammation, and severe local and systemic reactions in humans, respectively. Six ticks, including , and may transmit , or subsp. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360175PMC
January 2019
1 Read

Splenic infarction as a rare presentation of severe babesiosis.

IDCases 2019 23;15:e00491. Epub 2019 Jan 23.

Department of Medicine, St. Vincent's Medical Center, Bridgeport, CT; The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT, United States.

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http://dx.doi.org/10.1016/j.idcr.2019.e00491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355617PMC
January 2019

Paralogs vs. genotypes? Variability of Babesia canis assessed by 18S rDNA and two mitochondrial markers.

Vet Parasitol 2019 Feb 18;266:103-110. Epub 2019 Jan 18.

CEITEC-VFU, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 612 42, Brno, Czech Republic; Department of Pathological Morphology and Parasitology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 612 42, Brno, Czech Republic; Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branišovská 31, 370 05, České Budějovice, Czech Republic.

Canine babesiosis caused by Babesia canis sensu stricto became an emerging disease of dogs across Europe calling for attention also in countries where it was an only rare imported disease. An easy accessibility of molecular methods and the growing amount of sequencing data led to the description of intraspecific variability in 18S rDNA sequences designated as "genotypes". Using material from a homogenous cohort of dogs with microscopically confirmed canine babesiosis caused by B. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.12.017DOI Listing
February 2019
1 Read

Transgenic Babesia bovis lacking 6-Cys sexual-stage genes as the foundation for non-transmissible live vaccines against bovine babesiosis.

Ticks Tick Borne Dis 2019 Jan 25. Epub 2019 Jan 25.

Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA; Animal Disease Research Unit, United States Department of Agricultural - Agricultural Research Service, Pullman, WA, USA. Electronic address:

Babesia bovis, a tick-borne apicomplexan parasite responsible for bovine babesiosis has a complex life cycle including sexual development in its Rhipicephalus microplus vector. Understanding the molecular mechanisms involved in sexual development is essential for developing future-generation transmission blocking vaccines (TBVs) and/or non-transmissible attenuated live vaccines. The widely conserved members of the 6-Cys gene family likely play roles in the development of sexual stages of B. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1877959X183022
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http://dx.doi.org/10.1016/j.ttbdis.2019.01.006DOI Listing
January 2019
3 Reads

Congenital Babesiosis From Maternal Exposure: A Case Report.

J Emerg Med 2019 Jan 29. Epub 2019 Jan 29.

Division of Pediatric Emergency Medicine, NYU Langone Medical Center, New York, New York.

Background: Babesiosis is a disease caused by parasites that infect red blood cells; in infants it can be acquired from tick bites, blood transfusions, or congenitally via vertical transmission. It can present with thrombocytopenia, fevers, and parasitemia.

Case Report: A case of vertically transmitted babesiosis in an infant is described. Read More

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http://dx.doi.org/10.1016/j.jemermed.2018.12.044DOI Listing
January 2019

Human babesiosis.

Authors:
Peter J Krause

Int J Parasitol 2019 Jan 26. Epub 2019 Jan 26.

Yale School of Public Health and Yale School of Medicine, New Haven, CT, USA. Electronic address:

Babesiosis is a worldwide emerging tick-borne disease that is increasing in frequency and geographic range. It imposes a significant health burden, especially on those who are immunocompromised and those who acquire the infection through blood transfusion. Death from babesiosis occurs in up to 20 percent of these groups. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.11.007DOI Listing
January 2019

Unravelling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit?

Int J Parasitol 2019 Jan 26. Epub 2019 Jan 26.

Department of Microbiology, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia. Electronic address:

The global impact of bovine babesiosis caused by the tick-borne apicomplexan parasites Babesia bovis, Babesia bigemina and Babesia divergens is vastly underappreciated. These parasites invade and multiply asexually in bovine red blood cells (RBCs), undergo sexual reproduction in their tick vectors (Rhipicephalus spp. for B. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00207519183030
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http://dx.doi.org/10.1016/j.ijpara.2018.11.002DOI Listing
January 2019
4 Reads

Vaccination against babesiosis using recombinant GPI-anchored proteins.

Int J Parasitol 2019 Jan 24. Epub 2019 Jan 24.

Vaccination Anti-Parasitaire (VAP), University of Montpellier, France; Department of Veterinary Tropical Diseases, Veterinary Faculty, University of Pretoria, South Africa. Electronic address:

The increase in human babesiosis is of major concern to health authorities. In the USA, most of these cases are due to infections with Babesia microti, whereas in Europe B. divergens is the major cause of clinical disease in humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00207519193000
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http://dx.doi.org/10.1016/j.ijpara.2018.12.002DOI Listing
January 2019
8 Reads

Babesial infection in the Madagascan flying fox, Pteropus rufus É. Geoffroy, 1803.

Parasit Vectors 2019 Jan 23;12(1):51. Epub 2019 Jan 23.

Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.

Background: Babesiae are erythrocytic protozoans, which infect the red blood cells of vertebrate hosts to cause disease. Previous studies have described potentially pathogenic infections of Babesia vesperuginis in insectivorous bats in Europe, the Americas and Asia. To date, no babesial infections have been documented in the bats of Madagascar, or in any frugivorous bat species worldwide. Read More

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http://dx.doi.org/10.1186/s13071-019-3300-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343336PMC
January 2019

Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites.

Parasit Vectors 2019 Jan 16;12(1):37. Epub 2019 Jan 16.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan.

Background: Developing new antibabesial drugs with a low toxic effect to the animal and with no resistance from Babesia parasites is in urgent demand. In this concern, the antimalarial, anticancer and antioxidant effect of thymoquinone (TQ), a phytochemical compound found in the plant Nigella sativa, has been reported. Therefore, in the present study, the antibabesial effect of this compound was evaluated on the growth of piroplasm parasites. Read More

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http://dx.doi.org/10.1186/s13071-019-3296-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335684PMC
January 2019
1 Read
3.430 Impact Factor

Inhibitory effects of the phytohormone inhibitors fluridone and inabenfide against Babesia gibsoni in vitro.

Vet Parasitol 2019 Jan 7;265:19-23. Epub 2018 Dec 7.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan. Electronic address:

Pharmacological options to treat canine babesiosis caused by Babesia gibsoni, are limited. To address this challenge, screening for novel drug candidates and drug targets against B. gibsoni is urgently needed. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.11.018DOI Listing
January 2019
2 Reads

Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea.

Korean J Parasitol 2018 Dec 31;56(6):609-613. Epub 2018 Dec 31.

Department of Internal Medicine, Inha University School of Medicine, Incheon 22212, Korea.

Babesiosis, caused by Babesia microti and B. divergens, is transmitted by Ixodid ticks. Symptoms of babesiosis vary from a mild flu-like illness to acute, severe, and sometimes fatal and fulminant disease. Read More

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http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2018.56
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http://dx.doi.org/10.3347/kjp.2018.56.6.609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327201PMC
December 2018
5 Reads

Age-Related Differential Stimulation of Immune Response by and During Acute Phase of Infection Affects Disease Severity.

Front Immunol 2018 7;9:2891. Epub 2018 Dec 7.

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, United States.

Lyme disease is the most prominent tick-borne disease with 300,000 cases estimated by CDC every year while ~2,000 cases of babesiosis occur per year in the United States. Simultaneous infection with and are now the most common tick-transmitted coinfections in the U.S. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02891
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http://dx.doi.org/10.3389/fimmu.2018.02891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300717PMC
December 2018
4 Reads

Babesiosis prevalence in malaria-endemic regions of Colombia.

J Vector Borne Dis 2018 Jul-Sep;55(3):222-229

Malaria Group, Faculty of Medicine, University of Antioquia, Medellín, Colombia.

Background & Objectives: : The presence of Babesia spp in humans, bovine cattle and ticks (the transmitting vector) has not been well characterized in Colombia. Babesia infection in humans can be overlooked due to similarity of the disease symptoms with malaria specially in the regions where malaria is endemic. The aim of the present work was to study the frequency of Babesia infection in humans, bovines and ticks in a malaria endemic region of Colombia, and explore the possible relationship of infection with host and the environmental factors. Read More

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http://www.jvbd.org/text.asp?2018/55/3/222/249480
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http://dx.doi.org/10.4103/0972-9062.249480DOI Listing
February 2019
4 Reads

What is your diagnosis? A feline blood smear.

Vet Clin Pathol 2019 Jan 7. Epub 2019 Jan 7.

Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.

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http://dx.doi.org/10.1111/vcp.12682DOI Listing
January 2019

Silencing expression of the Rhipicephalus microplus vitellogenin receptor gene blocks Babesia bovis transmission and interferes with oocyte maturation.

Parasit Vectors 2019 Jan 5;12(1). Epub 2019 Jan 5.

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, 99164, USA.

Background: Rhipicephalus microplus is an efficient biological vector of Babesia bovis, a causative agent of bovine babesiosis. Babesia bovis is passed transovarially to the next generation of ticks, which then transmit the parasite to naïve animals. Due to the importance of the R. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3270-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321724PMC
January 2019
1 Read

Development and validation of a multiplex, real-time PCR assay for Babesia rossi and Babesia vogeli.

Ticks Tick Borne Dis 2019 02 14;10(2):421-432. Epub 2018 Dec 14.

Vector and Vector-borne Diseases Programme, Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa. Electronic address:

Canine babesiosis is caused by tick-transmitted intraerythrocytic protozoan parasites occurring worldwide. In southern Africa, babesiosis is caused by Babesia rossi and B. vogeli and is one of the most common and important infectious diseases affecting dogs. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.12.004DOI Listing
February 2019
2 Reads

Identification and molecular characterization of a novel Babesia orientalis thrombospondin-related anonymous protein (BoTRAP1).

Parasit Vectors 2018 Dec 27;11(1):667. Epub 2018 Dec 27.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.

Background: The thrombospondin-related anonymous protein (TRAP) family, a kind of transmembrane protein, is widely distributed with a conserved feature of structure in all apicomplexan parasites and plays a crucial role in the gliding motility and survival of parasites.

Methods: The Babesia orientalis TRAP1 gene (BoTRAP1) was truncated and cloned into a pET-42b expression vector and expressed as a GST-tag fusion protein with a TEV protease site. Rabbit anti-rBoTRAP1 antibody was produced and purified using a protein A chromatography column. Read More

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http://dx.doi.org/10.1186/s13071-018-3245-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307320PMC
December 2018
2 Reads

Molecular study of transovarial transmission of Babesia canis in the Dermacentor reticulatus tick.

Ann Agric Environ Med 2018 Dec 26;25(4):669-671. Epub 2018 Sep 26.

Faculty of Biology, University of Warsaw, Poland.

The Dermacentor reticulatus tick is a main vector of Babesia canis in Europe. The risk of canine babesiosis is unpredictable, due to significant differences in the prevalence of B. canis between ticks originating from closely situated regions. Read More

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http://dx.doi.org/10.26444/aaem/94673DOI Listing
December 2018

Babesiosis as a cause of acute respiratory distress syndrome: a series of eight cases.

Postgrad Med 2018 Dec 26:1-6. Epub 2018 Dec 26.

a Division of Pulmonary, Critical Care, and Sleep Medicine , Westchester Medical Center , Valhalla , NY , USA.

Objectives: The characteristics of patients with Acute Respiratory Distress Syndrome (ARDS) as a complication of Babesia microti infection have not been systematically described.

Methods: Adult patients admitted to the medical intensive care unit (MICU) of a tertiary care hospital in the Lower Hudson Valley of New York from 1/1/2008 to 8/1/2016 were evaluated for ARDS complicating babesiosis.

Results: Of 22 patients with babesiosis in the MICU, eight (36. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1558910DOI Listing
December 2018
11 Reads

Molecular characterization of South Indian field isolates of bovine Babesia spp. and Anaplasma spp.

Parasitol Res 2019 Feb 17;118(2):617-630. Epub 2018 Dec 17.

Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Pookode, Wayanad, Kerala, 673 576, India.

Ticks and tick-borne diseases (TTBDs) are considered major causes of economic loss in the livestock sector which incur an annual control cost estimated at US$ 498.7 million in India. Among these diseases, babesiosis, theileriosis and anaplasmosis are listed among the top ten livestock diseases in India and cause significant mortality and morbidity among cattle. Read More

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http://dx.doi.org/10.1007/s00436-018-6172-4DOI Listing
February 2019

International survey on the impact of parasitic infections: frequency of transmission and current mitigation strategies.

Vox Sang 2019 Jan 6;114(1):17-27. Epub 2018 Dec 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background And Objectives: Globally, blood safety interventions have been successful in mitigating risk of the major transfusion-transmitted (TT) viruses. However, strategies that address risk from parasites are comparatively limited. TT parasites are often regional in nature, posing unique challenges; we sought to understand their impact on blood safety. Read More

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http://dx.doi.org/10.1111/vox.12727DOI Listing
January 2019
4 Reads

Babesiosis-Associated Splenic Rupture: Case Series from a Hyperendemic Region.

Clin Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University.

Background: Spontaneous splenic rupture is an increasingly reported complication of babesiosis and has been described as a severe complication.

Methods: We performed a retrospective chart review in a high prevalence area to identify seven cases of babesiosis-related splenic rupture between 2014 - 2016.

Results: Splenic rupture occurred in approximately 1% of babesiosis cases. Read More

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http://dx.doi.org/10.1093/cid/ciy1060DOI Listing
December 2018
1 Read

Transplacental transmission of Theileria equi in mules: Should we worry?

Vet Parasitol 2018 Dec 26;264:39-41. Epub 2018 Oct 26.

College of Veterinary Medicine and Animal Science, University of São Paulo, Department of Internal Medicine, São Paulo, Brazil. Electronic address:

Equine piroplasmosis, disease globally responsible for significant economic losses, is caused by the transmission of the hemoprotozoa Theileria equi and Babesia caballi by ticks. Transplacental transmission has been reported previously in horses, which is not the case for mules´ foals. The present study investigated, by Real Time-PCR (RT-PCR), the presence of both Theileria equi and Babesia caballi in newborn mules before the ingestion of colostrum. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.10.017DOI Listing
December 2018
2 Reads

Endochin-Like Quinolones Exhibit Promising Efficacy Against and in Experimentally Infected Pregnant Mice.

Front Vet Sci 2018 19;5:285. Epub 2018 Nov 19.

Vetsuisse Faculty, Institute of Parasitology, University of Bern, Bern, Switzerland.

We report on the efficacy of selected endochin-like quinolones (ELQs) against tachyzoites grown in human foreskin fibroblasts (HFF), and in a pregnant BALB/c mouse model. Fourteen ELQs were screened against transgenic tachyzoites expressing β-galactosidase (Nc-βgal). Drugs were added concomitantly to infection and the values for 50% proliferation inhibition (IC) were determined after 3 days. Read More

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http://dx.doi.org/10.3389/fvets.2018.00285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252379PMC
November 2018
1 Read

The impact of Babesia microti blood donation screening.

Transfusion 2019 Feb 30;59(2):593-600. Epub 2018 Nov 30.

Scientific Affairs, American Red Cross Holland Laboratory, Rockville, Maryland.

Background: Babesia microti, an intraerythrocytic parasite endemic in the Northeast and upper Midwest United States, is responsible for over 200 reported cases of transfusion-transmitted babesiosis (TTB). The American Red Cross has prospectively screened donations in endemic areas for B. microti since 2012. Read More

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http://dx.doi.org/10.1111/trf.15043DOI Listing
February 2019
2 Reads

LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study.

PLoS One 2018 28;13(11):e0207245. Epub 2018 Nov 28.

ERA Chair"VetMedZg", Clinic for Internal diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb, Croatia.

Phosphorylation is the most commonly studied protein post-translational modification (PTM) in biological systems due to its importance in controlling cell division, survival, growth, etc. Despite the thorough research in phosphoproteomics of cells and tissues there is little information on circulating phosphoproteins. We compared serum from 10 healthy dogs and 10 dogs affected by B. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207245PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261647PMC
November 2018

Babesia gibsoni endemic to Wuhan, China: mitochondrial genome sequencing, annotation, and comparison with apicomplexan parasites.

Parasitol Res 2019 Jan 24;118(1):235-243. Epub 2018 Nov 24.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.

Babesia gibsoni (B. gibsoni), an intracellular apicomplexan protozoan, poses great threat to canine health. Currently, little information is available about the B. Read More

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http://dx.doi.org/10.1007/s00436-018-6158-2DOI Listing
January 2019
2 Reads

in three imported dogs: a new tickborne disease reaching the United Kingdom.

Vet Rec 2018 Dec 21;183(23):716. Epub 2018 Nov 21.

Diagnostic Laboratories, Langford Vets, Bristol Veterinary School, University of Bristol, Langford, UK.

An increasing number of non-endemic vectorborne pathogens have been described in dogs imported to the UK in the past two decades. Recently, an outbreak of canine babesiosis in south-east England has raised veterinary awareness with regard to the impact of such diseases on the UK canine population. Canine hepatozoonosis, caused by and transmitted by the ingestion of ticks, is widespread in the Mediterranean basin. Read More

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http://dx.doi.org/10.1136/vr.105087DOI Listing
December 2018
6 Reads

Establishment of a continuous culture of in human erythrocytes reveals unusually high tolerance to recommended therapies.

J Biol Chem 2018 Dec 21;293(52):19974-19981. Epub 2018 Nov 21.

From the Department of Internal Medicine, Section of Infectious Diseases, and

Human babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the genus Clinical cases caused by have been associated with high parasite burden, severe pathology, and death. In both mice and hamsters, the parasite causes uncontrolled fulminant infections, which ultimately lead to death. Resolving these infections requires knowledge of biology, virulence, and susceptibility to anti-infectives, but little is known and further research is hindered by a lack of relevant model systems. Read More

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http://dx.doi.org/10.1074/jbc.AC118.005771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311517PMC
December 2018
7 Reads
4.573 Impact Factor

Molecular identification of Babesia spp isolated from Polish cattle with asymptomatic protozoa infections.

Pol J Vet Sci 2018 Jun;21(2):287-291

Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences Lublin, Głęboka 30, 20-612 Lublin, Poland.

The aim of the paper was to study the epizootic situation of babesiosis in the cattle population in eastern Poland and possibly to determine what species of protozoa infects Polish cattle. Blood samples for molecular analysis (real time PCR) were collected from 192 dairy cows from various farms located in eastern Poland. The infection was detected in 10. Read More

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http://dx.doi.org/10.24425/119050DOI Listing
June 2018
1 Read

Optimizing exchange transfusion for patients with severe Babesia divergens babesiosis: Therapeutically-Rational Exchange (T-REX) of M antigen-negative and/or S antigen-negative red blood cells should be evaluated now.

Transfus Clin Biol 2019 Feb 19;26(1):76-79. Epub 2018 Oct 19.

Biconcavity Inc., Lilburn, GA, USA; Retired USPHS Commissioned Corps, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Babesia divergens is an intraerythrocytic parasite, which is the major cause of babesiosis in Europe. For years, clinicians have been publishing stunning case reports that describe how some - but not all - conventional red blood cell (RBC) exchange transfusions have saved the lives of severely ill babesiosis patients. Due to markedly different patient outcomes, clinicians agree that new treatments and additional studies are needed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12467820183028
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http://dx.doi.org/10.1016/j.tracli.2018.10.001DOI Listing
February 2019
8 Reads

To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia.

Int J Parasitol 2018 Nov 1. Epub 2018 Nov 1.

Harvard T. H. Chan School of Public Health, 651 Huntington Ave, Boston, MA 02115, USA. Electronic address:

Babesia parasites infect a diverse range of vertebrate hosts, from penguins to pigs. Recently, the emergence of zoonotic Babesia infection has been increasing, and the list of species reported to infect humans continues to grow. Babesiosis represents a burgeoning veterinary and medical threat, and the need for novel therapeutic drugs to effectively target this diverse group of parasites is pressing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00207519183024
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http://dx.doi.org/10.1016/j.ijpara.2018.09.005DOI Listing
November 2018
10 Reads

Analysis of the Babesia microti proteome in infected red blood cells by a combination of nanotechnology and mass spectrometry.

Int J Parasitol 2018 Nov 1. Epub 2018 Nov 1.

Protistology Laboratory, American Type Culture Collection, Manassas, VA 20110, USA. Electronic address:

Proteomics of Babesia microti has lagged behind other apicomplexans despite recent genome and transcriptome studies. Here, we used a combination of nanotechnology and mass spectrometry to provide a proteomic profile of B. microti acute infection. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.08.004DOI Listing
November 2018

Babesia bovis RON2 contains conserved B-cell epitopes that induce an invasion-blocking humoral immune response in immunized cattle.

Parasit Vectors 2018 Nov 3;11(1):575. Epub 2018 Nov 3.

Immunology and Vaccines Laboratory, C. A. Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Carretera a Chichimequillas, Ejido Bolaños, 76140, Queretaro, Queretaro, Mexico.

Background: Babesia bovis belongs to the phylum Apicomplexa and is the major causal agent of bovine babesiosis, the most important veterinary disease transmitted by arthropods. In apicomplexan parasites, the interaction between AMA1 and RON2 is necessary for the invasion process, and it is a target for vaccine development. In B. Read More

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http://dx.doi.org/10.1186/s13071-018-3164-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215676PMC
November 2018

High seroprevalence of Babesia antibodies among Borrelia burgdorferi-infected humans in Sweden.

Ticks Tick Borne Dis 2019 01 28;10(1):186-190. Epub 2018 Oct 28.

Department of Laboratory Medicine, Lund University, Skåne University Hospital, Lund, Sweden. Electronic address:

In northern Europe, tick-borne diseases such as Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are well known. The actual incidence of Babesia infections, however, has remained elusive. In this study, the prevalence of antibodies against two Babesia spp. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.10.007DOI Listing
January 2019
2 Reads

Transfusion-Transmitted Babesiosis.

Arch Pathol Lab Med 2019 Jan 30;143(1):130-134. Epub 2018 Oct 30.

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

Babesiosis is most commonly caused by Babesia microti and is transmitted via the bite of an infected Ixodes spp tick. However, Babesia is also transmitted via blood transfusion. In the United States, the first case of transfusion-transmitted babesiosis was recognized in 1979, and in recent years, the incidence has rapidly increased. Read More

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http://dx.doi.org/10.5858/arpa.2017-0250-RSDOI Listing
January 2019
1 Read

A library of recombinant Babesia microti cell surface and secreted proteins for diagnostics discovery and reverse vaccinology.

Int J Parasitol 2018 Oct 24. Epub 2018 Oct 24.

Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom. Electronic address:

Human babesiosis is an emerging tick-borne parasitic disease and blood transfusion-transmitted infection primarily caused by the apicomplexan parasite, Babesia microti. There is no licensed vaccine for B. microti and the development of a reliable serological screening test would contribute to ensuring the safety of the donated blood supply. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00207519183023
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http://dx.doi.org/10.1016/j.ijpara.2018.10.003DOI Listing
October 2018
13 Reads

Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease.

Int J Parasitol 2018 Oct 24. Epub 2018 Oct 24.

Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA. Electronic address:

The incidence of babesiosis, Lyme disease and other tick-borne diseases has increased steadily in Europe and North America during the last five decades. Babesia microti is transmitted by species of Ixodes, the same ticks that transmit the Lyme disease-causing spirochete, Borrelia burgdorferi. B. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.06.006DOI Listing
October 2018
2 Reads

Evidence for transmission of the zoonotic apicomplexan parasite Babesia duncani by the tick Dermacentor albipictus.

Int J Parasitol 2018 Oct 25. Epub 2018 Oct 25.

California Department of Public Health, Vector-Borne Disease Section, Sacramento, CA 95899, USA.

Babesiosis is a potentially fatal tick-borne zoonotic disease caused by a species complex of blood parasites that can infect a variety of vertebrates, particularly dogs, cattle, and humans. In the United States, human babesiosis is caused by two distinct parasites, Babesia microti and Babesia duncani. The enzootic cycle of B. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.07.002DOI Listing
October 2018
4 Reads

Development of multiplex PCR assay for concurrent detection of tick borne haemoparasitic infections in bovines.

Acta Parasitol 2018 Dec;63(4):759-765

Division of Biological Standardization, ICAR-IVRI, Izatnagar-243122 India.

This study describes development and evaluation of a multiplex PCR assay for simultaneous detection of Theileria annulata, Babesia bigemina and Anaplasma marginale infections in bovines. The assay was developed using parasites specific genomic DNA and three sets of PCR primers targeting the Tams1, 18S rRNA and 16S rRNA genes of T. annulata, B. Read More

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http://www.degruyter.com/view/j/ap.2018.63.issue-4/ap-2018-0
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http://dx.doi.org/10.1515/ap-2018-0090DOI Listing
December 2018
12 Reads

Comparative evaluation of DNA extraction kit, matrix sample and qPCR assays for bovine babesiosis monitoring.

Mol Biol Rep 2018 Dec 25;45(6):2671-2680. Epub 2018 Oct 25.

Embrapa Pecuária Sudeste, Rodovia Washington Luiz, Km 234, Fazenda Canchim, São Carlos, SP, 13560-970, Brazil.

Bovine babesiosis caused by protozoan parasites Babesia bovis and B. bigemina is one of the most important causes of losses for the livestock industry in tropical and subtropical regions of the world. Therefore, highly sensitive and specific tools for these hemoparasites detection and monitoring are required, especially in carrier animals, in which low parasite levels were usually present. Read More

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http://link.springer.com/10.1007/s11033-018-4436-9
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http://dx.doi.org/10.1007/s11033-018-4436-9DOI Listing
December 2018
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MOLECULAR DETECTION OF BABESIA ODOCOILEI IN WILD, FARMED, AND ZOO CERVIDS IN ONTARIO, CANADA.

J Wildl Dis 2018 Oct 19. Epub 2018 Oct 19.

1   Ontario Veterinary College, University of Guelph, 50 Stone Rd. E., Guelph, Ontario N1G 2W1, Canada.

Babesia odocoilei, a tick-borne protozoan hemoparasite of white-tailed deer ( Odocoileus virginianus), is being increasingly recognized as a cause of disease in captive cervids in North America. Historically endemic in white-tailed deer, the natural wildlife reservoir in the southeastern US, B. odocoilei has been recently associated with hemolytic anemia in captive Eurasian tundra reindeer ( Rangifer tarandus tarandus), wapiti ( Cervus canadensis), and woodland caribou ( Rangifer tarandus caribou) in the northcentral and northeastern US and several Canadian provinces. Read More

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http://www.jwildlifedis.org/doi/10.7589/2018-06-147
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http://dx.doi.org/10.7589/2018-06-147DOI Listing
October 2018
20 Reads

Human Babesiosis, Yucatán State, Mexico, 2015.

Emerg Infect Dis 2018 11;24(11):2061-2062

In 2015, we detected clinical cases of babesiosis caused by Babesia microti in Yucatán State, Mexico. Cases occurred in 4 children from a small town who became ill during the same month. Diagnosis was confirmed using conventional PCR followed by sequencing of the DNA fragment obtained. Read More

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http://wwwnc.cdc.gov/eid/article/24/11/17-0512_article.htm
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http://dx.doi.org/10.3201/eid2411.170512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199998PMC
November 2018
5 Reads

Current Status of Tick-Borne Diseases in South Korea.

Vector Borne Zoonotic Dis 2018 Oct 17. Epub 2018 Oct 17.

1 Department of Internal Medicine and Inha University School of Medicine , Incheon, Republic of Korea.

Background: Bites with tick-borne pathogens can cause various bacterial, viral, or parasitic diseases in humans. Tick-transmitted diseases are known as contributing factors to the increasing incidence and burden of diseases. The present article investigated the epidemiology of tick-borne diseases in South Korea. Read More

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http://dx.doi.org/10.1089/vbz.2018.2298DOI Listing
October 2018
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Prevalence of canine Babesia and Ehrlichia co-infection and the predictive value of haematology.

Onderstepoort J Vet Res 2018 Oct 9;85(1):e1-e5. Epub 2018 Oct 9.

Department of Companion Animal Clinical Studies, University of Pretoria.

Canine babesiosis and ehrlichiosis are important tick-borne infections in South Africa. Many South African general veterinary practitioners perceive co-infection with Ehrlichia spp. as a common occurrence in dogs with babesiosis. Read More

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http://dx.doi.org/10.4102/ojvr.v85i1.1626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324083PMC
October 2018
5 Reads

Babesia gibsoni cytochrome b mutations in canine blood samples submitted to a US veterinary diagnostic laboratory.

J Vet Intern Med 2018 Nov 11;32(6):1965-1969. Epub 2018 Oct 11.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

Background: Babesiosis caused by Babesia gibsoni is recognized throughout the world and can be difficult to treat. Resistance to atovaquone is associated with mutations in the B. gibsoni mitochondrial genome, specifically the M128 position of cytochrome b (cytb). Read More

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http://doi.wiley.com/10.1111/jvim.15300
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http://dx.doi.org/10.1111/jvim.15300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272040PMC
November 2018
2 Reads