243 results match your criteria BMJ open respiratory research[Journal]


First patient-centred set of outcomes for pulmonary sarcoidosis: a multicentre initiative.

BMJ Open Respir Res 2019 18;6(1):e000394. Epub 2019 Feb 18.

Department of Value-Based Healthcare, St. Antonius Hospital, Nieuwegein, The Netherlands.

Introduction: Routine and international comparison of clinical outcomes enabling identification of best practices for patients with pulmonary sarcoidosis is lacking. The aim of this study was to develop a standard set of outcome measures for pulmonary sarcoidosis, using the value-based healthcare principles.

Methods: Six expert clinics for interstitial lung diseases in four countries participated in a consensus-driven RAND-modified Delphi study. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424298PMC
February 2019
1 Read

Pneumomediastinum in marijuana users: a retrospective review of 14 cases.

BMJ Open Respir Res 2019 12;6(1):e000391. Epub 2019 Feb 12.

Division of Pulmonary and Critical Care and Department of Internal Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Introduction: Inhaled marijuana has been infrequently identified as a potential risk factor for the development of spontaneous pneumomediastinum (SPM), a rare finding of free air in the mediastinum likely caused by barotrauma during breathing manoeuvres. The mechanism of inhalation drug use is often not ascertained by physicians, thus little is known about how different smoking techniques precipitate pulmonary injury. We aimed to evaluate the frequency of marijuana use in patients with non-traumatic pneumomediastinum over a 12-month period, identifying additional relevant clinical features or risk factors, and determining the extent to which clinicians record smoking techniques. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424304PMC
February 2019
1 Read

Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients.

BMJ Open Respir Res 2019 18;6(1):e000383. Epub 2019 Feb 18.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Introduction: Acute rehabilitation in critically ill patients can improve post-intensive care unit (post-ICU) physical function. In-bed cycling early in a patient's ICU stay is a promising intervention. The objective of this study was to determine the feasibility of recruitment, intervention delivery and retention in a multi centre randomised clinical trial (RCT) of early in-bed cycling with mechanically ventilated (MV) patients. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424272PMC
February 2019
2 Reads

Sex and intimacy in people with severe asthma: a qualitative study.

BMJ Open Respir Res 2019 12;6(1):e000382. Epub 2019 Feb 12.

Respiratory Medicine, Beaumont Hospital, Dublin, Ireland.

Introduction: People with severe asthma experience unpredictable daily symptoms requiring an intense treatment regimen impacting on health-related quality of life (QoL). Sexuality contributes to this, yet there is a dearth of research exploring intimacy in people with severe asthma. We aimed to explore the patient's perception of the impact of severe asthma on intimacy, establish their information needs and their perceived role of the healthcare practitioner. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424302PMC
February 2019
1 Read

, a potential predictive biomarker of pulmonary infection in cystic fibrosis.

BMJ Open Respir Res 2019 12;6(1):e000374. Epub 2019 Mar 12.

EA3882-Laboratoire de Biodiversité et Ecologie Microbienne (LUBEM), Universite de Bretagne Occidentale, Brest, France.

Introduction: pulmonary infections are the primary cause of morbi-mortality in patients with cystic fibrosis (CF). In this cohort study, the objective was to identify candidate biomarkers of infection within the airway microbiota.

Methods: A 3-year prospective multicentre study (PYOMUCO study) was conducted in Western France and included patients initially free for at least 1 year. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424284PMC
March 2019
2 Reads

Safety and efficacy of ambulatory management of secondary spontaneous pneumothorax: a case series.

BMJ Open Respir Res 2019 28;6(1):e000373. Epub 2019 Feb 28.

Respiratory Medicine, Kettering General Hospital NHS Foundation Trust, Kettering, UK.

Introduction: The optimal management of pneumothorax remains undefined. There is a growing consensus that patients with spontaneous pneumothorax can be considered for ambulatory management with the use of a one-way valve. Despite this, there is little data on the outcomes of outpatient management of secondary spontaneous pneumothorax (SSP). Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424293PMC
February 2019

Relating Experienced To Recalled breathlessness Observational (RETRO) study: a prospective study using a mobile phone application.

BMJ Open Respir Res 2019 12;6(1):e000370. Epub 2019 Feb 12.

Department of Clinical Sciences, Division of Respiratory Medicine and Allergology, Lund University, Lund, Sweden.

Background: Breathlessness, the subjective sensation of breathing discomfort, is common and appears in the daily life of people with cardiorespiratory diseases. Physicians often rely on patient's history based on symptom recall. The relation between recalled and experienced breathlessness is still poorly understood. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424247PMC
February 2019

The King's Brief Interstitial Lung Disease (KBILD) questionnaire: an updated minimal clinically important difference.

BMJ Open Respir Res 2019 18;6(1):e000363. Epub 2019 Feb 18.

Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Introduction: The King's Brief Interstitial Lung Disease (KBILD) is a 15-item validated health-related quality of life (HRQOL) questionnaire. The method of scoring the KBILD has recently changed to incorporate a logit-scale transformation from one that used raw item responses, as this is potentially a more linear scale. The aim of this study was to re-evaluate the KBILD minimal clinically important difference (MCID) using the new logit -transformed scoring. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424243PMC
February 2019
2 Reads

Sarcoidosis in the UK: insights from British Thoracic Society registry data.

BMJ Open Respir Res 2019 18;6(1):e000357. Epub 2019 Feb 18.

Department of Respiratory Medicine, Hammersmith Hospital, London, UK.

Introduction: The British Thoracic Society Sarcoidosis Registry allows physicians to record clinical data after gaining written consent from patients. The registry's aim is to phenotype sarcoidosis in the UK.

Methods: Between February 2013 and July 2017, demographic details for 308 patients (with complete clinical data for 205 patients) presenting to 24 UK hospitals were recorded. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424275PMC
February 2019
1 Read

Veterans Specific Activity Questionnaire (VSAQ): a new and efficient method of assessing exercise capacity in patients with pulmonary arteriovenous malformations.

BMJ Open Respir Res 2019 1;6(1):e000351. Epub 2019 Mar 1.

NHLI Vascular Sciences, Imperial College London, London, UK.

Introduction: Assessment of performance status is an important component of clinical management of patients with pulmonary arteriovenous malformations (PAVMs). Usual methods are time-consuming and insensitive to variations within normal or supranormal exercise capacity.

Methods: The Veterans Specific Activity Questionnaire (VSAQ) was modified to facilitate completion by patients independently. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424292PMC
March 2019
1 Read

Real-world use of rescue inhaler sensors, electronic symptom questionnaires and physical activity monitors in COPD.

BMJ Open Respir Res 2019 18;6(1):e000350. Epub 2019 Feb 18.

Research & Development, GSK, Collegeville, Pennsylvania, USA.

Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterised by airflow obstruction and other morbidities such as respiratory symptoms, reduced physical activity and frequent bronchodilator use. Recent advances in personal digital monitoring devices can permit continuous collection of these data in COPD patients, but the relationships among them are not well understood.

Methods: 184 individuals from a single centre of the COPDGene cohort agreed to participate in this 3-week observational study. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424295PMC
February 2019
1 Read

Use, utility and methods of telehealth for patients with COPD in England and Wales: a healthcare provider survey.

BMJ Open Respir Res 2019 18;6(1):e000345. Epub 2019 Feb 18.

Respiratory Medicine, University College London Medical School, London, UK.

Introduction: Although the effectiveness of domiciliary monitoring (telehealth) to improve outcomes in chronic obstructive pulmonary disease (COPD) is controversial, it is being used in the National Health Service (NHS).

Aim: To explore the use of teleheath for COPD across England and Wales, to assess the perceptions of clinicians employing telehealth in COPD and to summarise the techniques that have been used by healthcare providers to personalise alarm limits for patients with COPD enrolled in telehealth programmes.

Methods: A cross-sectional survey consisting of 14 questions was sent to 230 COPD community services in England and Wales. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424290PMC
February 2019
1 Read

Use of bubble continuous positive airway pressure (bCPAP) in the management of critically ill children in a Malawian paediatric unit: an observational study.

BMJ Open Respir Res 2019 8;6(1):e000280. Epub 2019 Mar 8.

Malawian College of Medicine, Lilongwe, Malawi.

Introduction: In low-resource countries, respiratory failure is associated with a high mortality risk among critically ill children. We evaluated the role of bubble continuous positive airway pressure (bCPAP) in the routine care of critically ill children in Lilongwe, Malawi.

Methods: We conducted an observational study between 26 February and 15 April 2014, in an urban paediatric unit with approximately 20 000 admissions/year (in-hospital mortality <5% approximately during this time period). Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424262PMC
March 2019
1 Read

Correction: .

Authors:

BMJ Open Respir Res 2018 19;5(1):e000274corr1. Epub 2018 Dec 19.

[This corrects the article DOI: 10.1136/bmjresp-2017-000274.]. Read More

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http://dx.doi.org/10.1136/bmjresp-2017-000274corr1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350735PMC
December 2018

Cell therapy for ARDS: efficacy of endobronchial versus intravenous administration and biodistribution of MAPCs in a large animal model.

BMJ Open Respir Res 2019 12;6(1):e000308. Epub 2019 Jan 12.

The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Pittsburgh, Pennsylvania, USA.

Introduction: Bone marrow-derived multipotent adult progenitor cells (MAPCs) are adult allogeneic adherent stem cells currently investigated clinically for use in acute respiratory distress syndrome (ARDS). To date, there is no agreement on which is the best method for stem cells delivery in ARDS. Here, we compared the efficacy of two different methods of administration and biodistribution of MAPC for the treatment of ARDS in a sheep model. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339992PMC
January 2019
2 Reads

MesoTRAP: a feasibility study that includes a pilot clinical trial comparing video-assisted thoracoscopic partial pleurectomy decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial.

BMJ Open Respir Res 2019 5;6(1):e000368. Epub 2019 Jan 5.

Papworth Trials Unit Collaboration, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.

Introduction: One of the most debilitating symptoms of malignant pleural mesothelioma (MPM) is dyspnoea caused by pleural effusion. MPM can be complicated by the presence of tumour on the visceral pleura preventing the lung from re-expanding, known as trapped lung (TL). There is currently no consensus on the best way to manage TL. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326291PMC
January 2019
1 Read

Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial.

BMJ Open Respir Res 2019 3;6(1):e000349. Epub 2019 Jan 3.

Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland.

Introduction: Intervention studies have mainly used oral nutritional supplements (ONS) for the management of patients with chronic obstructive pulmonary disease (COPD) identified as at nutritional risk. In this 12-month randomised feasibility trial, we assessed the (1) feasibility of the recruitment, retention and provision of two interventions: ONS and between-meal snacks (snacks) and (2) the potential impact of the provision of snacks and ONS on body weight and quality of life in patients with COPD.

Methods : Hospitalised patients with COPD, at nutritional risk, were randomised to ONS (n=19) or snacks (n=15) providing 600 kcal and 22 g protein a day in addition to regular daily diet. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326325PMC
January 2019
1 Read

British Thoracic Society guideline for bronchiectasis in adults.

BMJ Open Respir Res 2018 28;5(1):e000348. Epub 2018 Dec 28.

Host Defence Unit, Department of Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK.

The full British Thoracic Society Guideline for Bronchiectasis in Adults is published in . The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326298PMC
December 2018
3 Reads

Ensuring basic competency in chest tube insertion using a simulated scenario: an international validation study.

BMJ Open Respir Res 2018 10;5(1):e000362. Epub 2018 Dec 10.

Copenhagen Academy for Medical Education and Simulation (CAMES), University of Copenhagen and the Capital Region of Denmark, Rigshospitalet, Copenhagen, Denmark.

Introduction: Chest tube insertion can be associated with serious complications. A structured training programme is needed to minimise complications and enhance patient safety. Novices should pass a reliable test with solid evidence of validity before performing the procedure supervised on patients. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307557PMC
December 2018
7 Reads

Specialist palliative care, psychology, interstitial lung disease (ILD) multidisciplinary team meeting: a novel model to address palliative care needs.

BMJ Open Respir Res 2018 19;5(1):e000360. Epub 2018 Dec 19.

Bristol Interstitial Lung Disease Service, North Bristol NHS Trust, Bristol, UK.

Introduction: Patients with progressive idiopathic fibrotic interstitial lung disease (ILD), such as those with idiopathic pulmonary fibrosis (IPF), can have an aggressive disease course, with a median survival of only 3-5 years from diagnosis. The palliative care needs of these patients are often unmet. There are calls for new models of care, whereby the patient's usual respiratory clinician remains central to the integration of palliative care principles and practices into their patient's management, but the optimal model of service delivery has yet to be determined. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307575PMC
December 2018
21 Reads

Inconsistent calculation methodology for the eucapnic voluntary hyperpnoea test affects the diagnosis of exercise-induced bronchoconstriction.

BMJ Open Respir Res 2018 18;5(1):e000358. Epub 2018 Dec 18.

School of Kinesiology, University of British Columbia, Vancouver, Canada.

Introduction: The eucapnic voluntary hyperpnoea (EVH) challenge is used to screen for exercise-induced bronchoconstriction. Several criteria have been proposed to determine the decrease in lung function (fall index, FI) following EVH. We compared three published FI calculation methods to determine if they affect the diagnostic classification. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307554PMC
December 2018
2 Reads

Multicentre pilot study evaluation of lung ultrasound for the management of paediatric pneumonia in low-resource settings: a study protocol.

BMJ Open Respir Res 2018 19;5(1):e000340. Epub 2018 Dec 19.

International Programs, Save the Children Federation Inc, Fairfield, Connecticut, USA.

Introduction: Pneumonia is the leading infectious cause of death among children under 5 years of age worldwide. However, pneumonia is challenging to diagnose. Lung ultrasound (LUS) is a promising diagnostic technology. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307622PMC
December 2018
14 Reads

Initial experience with transbronchial cryoablation as a novel local treatment for malignant peripheral lung lesions.

BMJ Open Respir Res 2018 15;5(1):e000315. Epub 2018 Dec 15.

Division of General Thoracic Surgery, Department of Surgery, Tokai University School of Medicine, Isehara, Japan.

Introduction: Percutaneous cryoablation has been adopted for small, malignant peripheral pulmonary lesions and has yielded favourable results as a less invasive local treatment. A transbronchial approach may reduce the risks of complications, such as pneumothorax and pleural haemorrhage. A fundamental animal experiment on transbronchial cryoablation was performed to examine its immediate safety and effectiveness. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307616PMC
December 2018
9 Reads

Baseline clinical characteristics, comorbidities and prescribed medication in a real-world population of patients with idiopathic pulmonary fibrosis: the PROOF registry.

BMJ Open Respir Res 2018 21;5(1):e000331. Epub 2018 Nov 21.

Department of Respiratory Medicine, Erasme University Hospital, Brussels, Belgium.

Introduction: PROOF (a Prospective Observational Registry to Describe the Disease Course and Outcomes of Idiopathic Pulmonary Fibrosis) is an ongoing, observational registry initiated in 2013 with the aim of collecting real-world data from patients with idiopathic pulmonary fibrosis (IPF). Here, we present comprehensive baseline data, which were collected from patients on registry inclusion.

Methods: Patients with IPF were enrolled across eight centres in Belgium and Luxembourg. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267319PMC
November 2018
7 Reads

Visual rating assessment of cerebral atrophy and its relationship with cognitive function in chronic obstructive pulmonary disease.

BMJ Open Respir Res 2018 26;5(1):e000310. Epub 2018 Nov 26.

Academic Respiratory Unit, Clinical Sciences, University of Bristol, Bristol, UK.

Introduction: Widespread white matter damage and cognitive impairment have been demonstrated in chronic obstructive pulmonary disease (COPD). However, it remains unclear if brain atrophy is a global phenomenon or if specific subregions are differentially affected. The aims of this study are, first, to test a simple, validated visual analogue grading technique. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267327PMC
November 2018
1 Read

Temporal analysis of determinants for respiratory emergency department visits in a large German hospital.

BMJ Open Respir Res 2018 1;5(1):e000338. Epub 2018 Nov 1.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Introduction: Associations between air pollutants, meteorological conditions and respiratory diseases have been extensively shown. The aim of this study was to investigate associations between daily meteorological data, data on air pollution and emergency department (ED) visits depending on the day of the week, season and year (study period from 2013 to 2015).

Methods: Highly correlated environmental data entered a categorical principal components analysis (CATPCA). Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241969PMC
November 2018

Acute exacerbation of idiopathic pulmonary fibrosis: a 10-year single-centre retrospective study.

BMJ Open Respir Res 2018 9;5(1):e000342. Epub 2018 Oct 9.

Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Kobe, Japan.

Introduction: In 2016, an international working group proposed a revised definition and new diagnostic criteria for the acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). Based on these criteria, AE-IPF was diagnosed regardless of the presence or absence of a known trigger and categorised as triggered (T-AE) or idiopathic (I-AE) AE-IPF. However, the clinical characteristics of the newly defined AE-IPF and clinical differences between T-AE and I-AE are unresolved. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203000PMC
October 2018
13 Reads

Monitoring tuberculosis contact tracing outcomes in Western Sydney, Australia.

BMJ Open Respir Res 2018 25;5(1):e000341. Epub 2018 Oct 25.

The University of Sydney, Sydney, New South Wales, Australia.

Treatment of latent tuberculosis infection (LTBI) is an important component of strategies to achieve global tuberculosis (TB) elimination, but implementation is rarely monitored. This is a retrospective review of TB contact tracing outcomes at one of the busiest TB clinics in Australia, measured against the Centre for Disease Control and Prevention performance indicators. In total, 45 of 53 (85%) pulmonary TB cases had 171 close contacts, of whom 139 (81%) were evaluated with a tuberculin skin test (TST); 58 of 139 (42%) were positive at baseline. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203069PMC
October 2018
31 Reads

Study investigating the generalisability of a COPD trial based in primary care (Salford Lung Study) and the presence of a Hawthorne effect.

BMJ Open Respir Res 2018 25;5(1):e000339. Epub 2018 Oct 25.

Farr Institute, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Introduction: Traditional phase IIIb randomised trials may not reflect routine clinical practice. The Salford Lung Study in chronic obstructive pulmonary disease (SLS COPD) allowed broad inclusion criteria and followed patients in routine practice. We assessed whether SLS COPD approximated the England COPD population and evidence for a Hawthorne effect. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203022PMC
October 2018
3 Reads

Specialist emergency care and COPD outcomes.

BMJ Open Respir Res 2018 14;5(1):e000334. Epub 2018 Oct 14.

Respiratory Research Division, Research and Development, Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, North Shields, UK.

Introduction: In exacerbation of chronic obstructive pulmonary disease (ECOPD) requiring hospitalisation greater access to respiratory specialists improves outcome, but is not consistently delivered. The UK National Confidential Enquiry into Patient Outcome and Death 2015 enquiry showed over 25% of patients receiving acute non-invasive ventilation (NIV) for ECOPD died in hospital. On 16 June 2015 the Northumbria Specialist Emergency Care Hospital (NSECH) opened, introducing 24/7 specialty consultant on-call, direct admission from the emergency department to specialty wards and 7-day consultant review. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203006PMC
October 2018
2 Reads

Novel pharmacist-led intervention secures the minimally important difference (MID) in Asthma Control Test (ACT) score: better outcomes for patients and the healthcare provider.

BMJ Open Respir Res 2018 14;5(1):e000322. Epub 2018 Oct 14.

Sussex Pharmacy, School of Life Sciences, University of Sussex, Brighton, UK.

Introduction: A key priority in asthma management is achieving control. The Asthma Control Test (ACT) is a validated tool showing a numerical indicator which has the potential to provide a target to drive management. A novel pharmacist-led intervention recently evaluated and introduced in the Italian setting with a cluster randomised controlled trial (C-RCT) showed effectiveness and cost-effectiveness. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203066PMC
October 2018
5 Reads

Comparison of patient-reported outcomes during acute exacerbations of chronic obstructive pulmonary disease.

BMJ Open Respir Res 2018 9;5(1):e000305. Epub 2018 Oct 9.

Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: The aim of this study was to investigate which patient-reported outcome measure was the best during the recovery phase from severe exacerbation of chronic obstructive pulmonary disease (COPD).

Methods: The Exacerbations of Chronic Pulmonary Disease Tool (EXACT), the COPD Assessment Test (CAT), the St George's Respiratory Questionnaire (SGRQ), the Dyspnoea-12 (D-12) and the Hyland Scale (global scale) were recorded every week for the first month and at 2 and 3 months in 33 hospitalised subjects with acute exacerbation of COPD (AECOPD).

Results: On the day of admission (day 1), the internal consistency of the EXACT total score was high (Cronbach's alpha coefficient=0. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203045PMC
October 2018
4 Reads

Incidence of tuberculosis and the influence of surveillance strategy on tuberculosis case-finding and all-cause mortality: a cluster randomised trial in Indian neonates vaccinated with BCG.

BMJ Open Respir Res 2018 9;5(1):e000304. Epub 2018 Oct 9.

Division of Health and Humanities, St. John's Research Institute, Bangalore, Koramangala, India.

Introduction: Accurate tuberculosis (TB) incidence and optimal surveillance strategies are pertinent to TB vaccine trial design. Infants are a targeted population for new TB vaccines, but data from India, with the highest global burden of TB cases, is limited.

Methods: In a population-based prospective trial conducted between November 2006 and July 2008, BCG-vaccinated neonates in South India were enrolled and cluster-randomised to active or passive surveillance. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203048PMC
October 2018
18 Reads

Thoracic ultrasound: it's not all about the pleura.

BMJ Open Respir Res 2018 1;5(1):e000354. Epub 2018 Oct 1.

Department of Paediatric Intensive Care, Southampton Children's Hospital, Southampton, UK.

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http://dx.doi.org/10.1136/bmjresp-2018-000354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173226PMC
October 2018
5 Reads

Fever is associated with higher morbidity and clot burden in patients with acute pulmonary embolism.

BMJ Open Respir Res 2018 23;5(1):e000327. Epub 2018 Sep 23.

Department of Internal Medicine, BronxCare Health System, Bronx, New York, USA.

Background: Fever is considered as a presenting symptom of pulmonary embolism (PE). We aim to evaluate the association between PE and fever, its clinical characteristics, outcomes and role in prognosis.

Methods: A retrospective chart review of patients who were hospitalised with the diagnosis of acute PE was conducted. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157512PMC
September 2018
9 Reads

Gut microbiota relationships to lung function and adult asthma phenotype: a pilot study.

BMJ Open Respir Res 2018 23;5(1):e000324. Epub 2018 Sep 23.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Introduction: Despite strong evidence that maturation patterns of the gut microbiome in early life influence the risk for childhood asthma, very little is known about gut microbiota patterns in adults with established asthma, and of greater interest relationships to phenotypic features that characterise asthma heterogeneity.

Methods: Fifty-eight faecal samples from 32 adults with (n=24) and without (n=8) asthma were analysed using 16S ribosomal RNA gene sequencing methods to characterise intestinal bacterial composition. Compositional stability of paired samples was evaluated and features of gut bacterial community structure analysed in relation to extensive clinical characterisation data collected from subjects, who were enrolled in a prospective observational cohort study at the University of Michigan. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157510PMC
September 2018
15 Reads

Face mask sampling reveals antimicrobial resistance genes in exhaled aerosols from patients with chronic obstructive pulmonary disease and healthy volunteers.

BMJ Open Respir Res 2018 23;5(1):e000321. Epub 2018 Sep 23.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

Introduction: The degree to which bacteria in the human respiratory tract are aerosolised by individuals is not established. Building on our experience sampling bacteria exhaled by individuals with pulmonary tuberculosis using face masks, we hypothesised that patients with conditions frequently treated with antimicrobials, such as chronic obstructive pulmonary disease (COPD), might exhale significant numbers of bacteria carrying antimicrobial resistance (AMR) genes and that this may constitute a previously undefined risk for the transmission of AMR.

Methods: Fifteen-minute mask samples were taken from 13 patients with COPD (five paired with contemporaneous sputum samples) and 10 healthy controls. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157532PMC
September 2018
5 Reads

Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: design of a double-blind, randomised, placebo-controlled phase II trial.

BMJ Open Respir Res 2018 4;5(1):e000289. Epub 2018 Sep 4.

National Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Lyon, France.

Introduction: Despite extensive multidisciplinary team (MDT) assessment, some patients have interstitial lung disease (ILD) that is considered unclassifiable (uILD), for which there are currently no approved treatments. This study will assess the efficacy and safety of the antifibrotic pirfenidone in treating uILD.

Methods And Analysis: This double-blind, randomised, placebo-controlled phase II trial is enrolling adults with fibrosing ILD, including uILD that fulfils proposed research criteria for interstitial pneumonia with autoimmune features (IPAF), that cannot be classified with moderate or high confidence to any category of ILD following MDT discussion. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135451PMC
September 2018
1 Read

Metabolomics of World Trade Center-Lung Injury: a machine learning approach.

BMJ Open Respir Res 2018 3;5(1):e000274. Epub 2018 Sep 3.

Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.

Introduction: Biomarkers of metabolic syndrome expressed soon after World Trade Center (WTC) exposure predict development of WTC Lung Injury (WTC-LI). The metabolome remains an untapped resource with potential to comprehensively characterise many aspects of WTC-LI. This case-control study identified a clinically relevant, robust subset of metabolic contributors of WTC-LI through comprehensive high-dimensional metabolic profiling and integration of machine learning techniques. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2017-000274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135464PMC
September 2018
14 Reads

Correction: .

Authors:

BMJ Open Respir Res 2018 20;5(1):e000309corr1. Epub 2018 Aug 20.

[This corrects the article DOI: 10.1136/bmjresp-2018-000309.]. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000309corr1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109816PMC

Investigating the effects of nintedanib on biomarkers of extracellular matrix turnover in patients with IPF: design of the randomised placebo-controlled INMARK®trial.

BMJ Open Respir Res 2018 20;5(1):e000325. Epub 2018 Aug 20.

City Hospital, University of Nottingham, Nottingham, UK.

Introduction: A feature of the pathogenesis of idiopathic pulmonary fibrosis (IPF) is the excess accumulation of extracellular matrix (ECM) in the lungs. Cleavage of the ECM by metalloproteinases (MMPs) generates free-circulating protein fragments known as neoepitopes. The PROFILE study suggested that changes in ECM turnover proteins may be of value as markers of disease progression in patients with IPF. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109823PMC
August 2018
3 Reads

Dose modification and dose intensity during treatment with pirfenidone: analysis of pooled data from three multinational phase III trials.

BMJ Open Respir Res 2018 2;5(1):e000323. Epub 2018 Aug 2.

Cedars-Sinai Medical Center, Los Angeles, California, USA.

Introduction: Temporary dose modifications, such as reductions or interruptions, may allow patients to better manage adverse events (AEs) associated with pirfenidone use and continue treatment for idiopathic pulmonary fibrosis (IPF). However, the impact of such dosing adjustments on efficacy and safety is uncertain.

Methods: Patients randomised to receive treatment with pirfenidone 2403 mg/day or placebo in the Clinical Studies Assessing Pirfenidone in Idiopathic Pulmonary Fibrosis: Research of Efficacy and Safety Outcomes (CAPACITY (Study 004 (NCT00287716)) and Study 006 (NCT00287729))) and Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis (ASCEND (Study 016 (NCT01366209)) trials were included in the analysis (n=1247). Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089326PMC
August 2018
3 Reads

Step oximetry test: a validation study.

BMJ Open Respir Res 2018 3;5(1):e000320. Epub 2018 Aug 3.

Pulmonary Institute, Rabin Medical Center, Petah Tikva, Israel.

Introduction: Step climbing is a potentially useful modality for testing exercise capacity. However, there are significant variations between test protocols and lack of consistent validation against gold standard cycle ergometry cardiopulmonary exercise testing (CPET). The purpose of the study was to validate a novel technique of exercise testing using a dedicated device. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089267PMC
August 2018
9 Reads

Providing safe and effective pleural medicine services in the UK: an aspirational statement from UK pleural physicians.

BMJ Open Respir Res 2018 3;5(1):e000307. Epub 2018 Aug 3.

Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, UK.

Physicians face considerable challenges in ensuring safe and effective care for patients admitted to hospital with pleural disease. While subspecialty development has driven up standards of care, this has been tempered by the resulting loss of procedural experience in general medical teams tasked with managing acute pleural disease. This review aims to define a framework though which a minimum standard of care might be implemented. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089266PMC
August 2018
27 Reads

Reducing hospital admissions for COPD: perspectives following the Christchurch Earthquake.

BMJ Open Respir Res 2018 2;5(1):e000286. Epub 2018 Aug 2.

Pegasus Health Ltd, Christchurch, New Zealand.

The devastating 2011 earthquake in Christchurch destroyed or badly damaged healthcare infrastructure, including Christchurch Hospital. This forced change in management of exacerbations of chronic obstructive pulmonary disease (COPD), which until that point had frequently led to admission to hospital and focused attention on providing safe community options for care. This paper describes the process of understanding factors contributing to high admission frequency with exacerbations of COPD and also describes a process of change, predominantly to healthcare delivery systems and philosophies, and the subsequent outcomes. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2018-000286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089320PMC
August 2018
13 Reads

To intubate or not: ventilation is the question. A manikin-based observational study.

BMJ Open Respir Res 2018 17;5(1):e000261. Epub 2018 Jul 17.

Inserm CIC 1431, University Hospital of Besançon, Besancon, France.

Introduction: There is a continuous debate concerning the superiority of endotracheal intubation on bag-valve-mask (BVM) ventilation in patients with cardiac arrest. In this manikin-based observational study, we evaluate and compare the performance of manual ventilation through a facemask (BVM) and an endotracheal tube (ETT).

Methods: One hundred and forty healthcare providers were instructed to manually ventilate a manikin as they would do for a 75 kg adult patient in respiratory arrest. Read More

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http://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-201
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http://dx.doi.org/10.1136/bmjresp-2017-000261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089311PMC
July 2018
16 Reads

Transitions and touchpoints in idiopathic pulmonary fibrosis.

BMJ Open Respir Res 2018 29;5(1):e000317. Epub 2018 Jun 29.

Interstitial Lung Disease Program, National Jewish Health, Denver, Colorado, USA.

Patients with idiopathic pulmonary fibrosis (IPF) face a poor prognosis and endure intrusive symptoms that impair quality of life. Many patients with IPF will require supplemental oxygen (O) at some point in the course of their illness, and although it can improve blood oxygen and symptoms, O creates physical and emotional challenges for patients and their loved ones. Four events in the course of IPF-the first occurs at the time of diagnosis and the other three are related to O-herald periods of transition for patients and their caregivers and mark touchpoints when they need extra care and support from practitioners. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045697PMC

No association between DNA methylation and COPD in never and current smokers.

BMJ Open Respir Res 2018 29;5(1):e000282. Epub 2018 Jun 29.

University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.

Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease with cigarette smoke as the main risk factor for its development. Since not every smoker develops COPD, other factors likely underlie differences in susceptibility to develop COPD. Here, we tested if DNA methylation may be such a factor by assessing the association between DNA methylation levels and COPD in never and current smokers from the general population. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045732PMC
June 2018
1 Read

Validation of the Saint George's Respiratory Questionnaire in Uganda.

BMJ Open Respir Res 2018 11;5(1):e000276. Epub 2018 Jul 11.

Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Introduction: Chronic obstructive pulmonary disease (COPD) will soon be the third leading global cause of death and is increasing rapidly in low/middle-income countries. There is a need for local validation of the Saint George's Respiratory Questionnaire (SGRQ), which can be used to identify those experiencing lifestyle impairment due to their breathing.

Methods: The SGRQ was professionally translated into Luganda and reviewed by our field staff and a local pulmonologist. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045769PMC
July 2018
33 Reads

Understanding changes in dyspnoea perception in obstructive lung disease after mindfulness training.

BMJ Open Respir Res 2018 23;5(1):e000309. Epub 2018 Jun 23.

Academic Respiratory Unit, University of Bristol, Southmead Hospital, Bristol, UK.

Introduction: Dyspnoea has been defined as a 'subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity'. However, the majority of available dyspnoea measures treat it as a single entity and rely on quantitative methodology. We propose that qualitative research can enhance our understanding of dyspnoea, in particular, how perception varies so much among patients with similar disease states. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018883PMC
June 2018
5 Reads