353 results match your criteria BMJ open respiratory research[Journal]


ARTP statement on pulmonary function testing.

BMJ Open Respir Res 2020 Jul;7(1)

Lung Function and Sleep, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

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http://dx.doi.org/10.1136/bmjresp-2020-000664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337883PMC

ARTP statement on pulmonary function testing 2020.

BMJ Open Respir Res 2020 Jul;7(1)

Department of Respiratory Medicine, Dorset County Hospital NHS Foundation Trust, Dorchester, Dorset, UK.

The Association for Respiratory Technology & Physiology (ARTP) last produced a statement on the performance of lung function testing in 1994. At that time the focus was on a practical statement for people working in lung function laboratories. Since that time there have been many technological advances and alterations to best practice in the measurement and interpretation of lung function assessments. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337892PMC

Is continuous positive airway pressure (CPAP) a new standard of care for type 1 respiratory failure in COVID-19 patients? A retrospective observational study of a dedicated COVID-19 CPAP service.

BMJ Open Respir Res 2020 07;7(1)

Department of Respiratory Medicine, Tropical and Infectious Disease Unit, Intensive Care Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.

The aim of this case series is to describe and evaluate our experience of continuous positive airway pressure (CPAP) to treat type 1 respiratory failure in patients with COVID-19. CPAP was delivered in negative pressure rooms in the newly repurposed infectious disease unit. We report a cohort of 24 patients with type 1 respiratory failure and COVID-19 admitted to the Royal Liverpool Hospital between 1 April and 30 April 2020. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337881PMC

Improved survival following ward-based non-invasive pressure support for severe hypoxia in a cohort of frail patients with COVID-19: retrospective analysis from a UK teaching hospital.

BMJ Open Respir Res 2020 07;7(1)

Department of Respiratory Medicine, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK.

Since the outbreak of COVID-19 in China in December 2019, a pandemic has rapidly developed on a scale that has overwhelmed health services in a number of countries. COVID-19 has the potential to lead to severe hypoxia; this is usually the cause of death if it occurs. In a substantial number of patients, adequate arterial oxygenation cannot be achieved with supplementary oxygen therapy alone. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337887PMC

Time to diagnosis of idiopathic pulmonary fibrosis in the IPF-PRO Registry.

BMJ Open Respir Res 2020 Jul;7(1)

Medical University of South Carolina, Charleston, South Carolina, USA.

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality. Patient characteristics associated with diagnostic delays are not well described.

Methods: Subjects who had not been diagnosed with IPF prior to referral and received a new diagnosis of IPF at an enrolling centre for the IPF-PRO (diopathic ulmonary ibrosis spective Outcomes) Registry were characterised as having a longer (>1 year) or shorter (≤1 year) time from symptom onset to diagnosis and from first imaging evidence of fibrosis to diagnosis. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337884PMC

ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF.

BMJ Open Respir Res 2020 Jun;7(1)

Department of Respiratory Medicine, Oslo University Hospital - Rikshospitalet, Oslo, Norway.

Introduction: Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) are fibrotic ILDs with divergent disease populations. Little is known about health-related quality of life (HRQL) in SSc-ILD relative to IPF.

Methods: We used the Kings Brief Interstitial Lung Disease Questionnaire (K-BILD) to compare HRQL in a cross-sectional study of 57 patients with IPF and 29 patients with SSc-ILD. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312324PMC

Current and future management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the UK.

BMJ Open Respir Res 2020 Jun;7(1)

North Central London TB Service, Whittington Health NHS Foundation Trust, London, UK.

A rising number of non-tuberculous mycobacterial (NTM) isolates are being identified in UK clinical practice. There are many uncertainties around the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD), including its epidemiology, diagnosis, treatment and prevention. Regional variations in how patients with NTM-PD are managed reflects the lack of standardised pathways in the UK. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311041PMC

Intravenous iron and chronic obstructive pulmonary disease: a randomised controlled trial.

BMJ Open Respir Res 2020 Jun;7(1)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

Background: Increased iron availability modifies cardiorespiratory function in healthy volunteers and improves exercise capacity and quality of life in patients with heart failure or pulmonary hypertension. We hypothesised that intravenous iron would produce improvements in oxygenation, exercise capacity and quality of life in patients with chronic obstructive pulmonary disease (COPD).

Methods: We performed a randomised, placebo-controlled, double-blind trial in 48 participants with COPD (mean±SD: age 69±8 years, haemoglobin 144. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311010PMC

Characteristics of lung cancer in idiopathic pulmonary fibrosis with single lung transplant versus non-transplanted patients: a retrospective observational study.

BMJ Open Respir Res 2020 Jun;7(1)

Pulmonary Institute, Rabin Medical Center, Petah Tikva, Israel.

Background: Patients with idiopathic pulmonary fibrosis (IPF) have significantly higher incidence of lung cancer (LC) relative to the general population. There is a further increase in LC incidence in patients with IPF subsequent to lung transplant, specifically in patients with IPF undergoing single lung transplant.

Objectives: To examine the incidence and characteristics of LC in patients with IPF during follow-up and after lung transplantation (LTX). Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311020PMC

Gait speed is associated with death or readmission among patients surviving acute hypercapnic respiratory failure.

BMJ Open Respir Res 2020 Jun;7(1)

Division of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.

Objectives: Death or hospital readmission are frequent among patients surviving acute hypercapnic respiratory failure (AHRF). Severity scores are not valid to predict death or readmission after AHRF. Gait speed, a simple functional parameter, has been associated with hospital admission and death in the general population. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304813PMC

Readily accessible CT scoring method to quantify fibrosis in IPF.

BMJ Open Respir Res 2020 Jun;7(1)

Oxford Interstitial Lung Disease Service, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK

Introduction: There is currently no readily accessible measure to specifically quantify the amount of fibrosis in idiopathic pulmonary fibrosis (IPF). Such a measure could isolate contribution of fibrosis from other comorbidities to lung function abnormality and deterioration of disease, and potentially help determine if there has been response to antifibrotic treatment.

Methods: In a pilot study of 39 IPF patients, we used a CT-based visual scoring method to examine the correlation between the sum of all fibrotic features (all traction bronchiectasis, ground glass with traction bronchiectasis, honeycombing and reticulation; referred to as Total Fibrosis Score, TFS) or the individual fibrotic features, with lung function, Composite Physiologic Index (CPI) and time to death in the 5 years following CT measurement. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292044PMC

Feasibility study of in vitro drug sensitivity assay of advanced non-small cell lung adenocarcinomas.

BMJ Open Respir Res 2020 Jun;7(1)

Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, Pecs, Baranya, Hungary

Background Despite improved screening techniques, diagnosis of lung cancer is often late and its prognosis is poor. In the present study, in vitro chemosensitivity of solid tumours and pleural effusions of lung adenocarcinomas were analysed and compared with clinical drug response.Methods Tumour cells were isolated from resected solid tumours or pleural effusions, and cryopreserved. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292226PMC

Immediate effects of systemic administration of normal and high O-affinity haemoglobin vesicles as a transfusion alternative in a rat pneumonectomy model.

BMJ Open Respir Res 2020 Jun;7(1)

Division of General Thoracic Surgery, Department of Surgery, Tokai University-Isehara Campus, Isehara, Kanagawa, Japan.

Background: Haemoglobin vesicles (HbVs) are red blood cell (RBC) substitutes with a phospholipid bilayer membrane and a polyethylene modified surface (diameter=250 nm; P=28 Torr). They can be preserved for years and can be used in patients of all blood types without the risk of infection. Their oxygen affinity can be modified by changing the allosteric effectors. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292042PMC

Prognostic indicators for in-hospital mortality in COPD with acute exacerbation in Thailand: a retrospective cohort study.

BMJ Open Respir Res 2020 May;7(1)

Center for Clinical Epidemiology and Clinical Statistics, Chiang Mai University Faculty of Medicine, Chiang Mai, Thailand.

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common and deteriorating event leading to in-hospital morbidity and mortality. Identification of predictors for in-hospital mortality of AECOPD patients could aid clinicians in identifying patients with a higher risk of death during their hospitalisation.

Objective: To explore potential prognostic indicators associated with in-hospital mortality of AECOPD patients. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259855PMC

Association between self-reported moderate to vigorous physical activity and the rate of outpatient treated COPD exacerbations: retrospective cohort study.

BMJ Open Respir Res 2020 May;7(1)

Research and Evaluation, Kaiser Permanente Southern California Research and Evaluation, Pasadena, California, USA.

Introduction: Little has been published regarding the relationship between physical activity (PA) and outpatient treated, mild to moderate acute exacerbation of chronic obstructive pulmonary disease exacerbations (AECOPD). The purpose of this study was to determine the association between self-reported PA and outpatient treated AECOPD over 2 years using real-world data obtained from existing electronic medical records (EMRs).

Methods: We included 44 896 patients with a chronic obstructive pulmonary disease diagnosis from the EMR in this retrospective cohort study. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264694PMC

Prompt recognition of infectious pulmonary tuberculosis is critical to achieving elimination goals: a retrospective cohort study.

BMJ Open Respir Res 2020 May;7(1)

Department of Medicine; Division of Pulmonary Medicine, University of Alberta, Edmonton, Alberta, Canada

Introduction: All pulmonary tuberculosis (PTB) cases are presumed to be infectious to some degree. This spectrum of infectiousness is independently described by both the acid-fast bacilli smear and radiographic findings. Smear-positive patients with chest radiographic findings that are typical for adult-type PTB are believed to be most infectious. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252995PMC

British Thoracic Society Training Standards for Thoracic Ultrasound (TUS).

BMJ Open Respir Res 2020 May;7(1)

Respiratory Medicine, Royal Berkshire Hospital, Reading, Reading, UK

Introduction: The British Thoracic Society (BTS) responded to a call from the pleural community to establish this new Training Standard to detail the capabilities in practice for thoracic ultrasound (TUS), which will build on the previous curricula and extend the remit to include training for the emergency provision of TUS.

Methods: BTS convened a working group to produce a set of Training Standards.

Results: This document provides a comprehensive Training Standard for TUS facilitating timely and improved management of patients with respiratory presentations, particularly (but not exclusively) pleural pathologies. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245450PMC

Efficacy of recombinant thrombomodulin for poor prognostic cases of acute exacerbation in idiopathic interstitial pneumonia: secondary analysis of the SETUP trial.

BMJ Open Respir Res 2020 May;7(1)

Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan

Background: Acute exacerbation (AE) in idiopathic pulmonary fibrosis and other idiopathic interstitial pneumonias (IIPs) are poor prognostic events although they are usually treated with conventional therapy with corticosteroids and immunosuppressants. Previously, we demonstrated the safety and efficacy of recombinant human soluble thrombomodulin (rhTM) for AE-IIP in the SETUP trial. Here, we aimed to clarify the efficacy of rhTM for poor-prognosis cases of AE-IIP. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239513PMC

Uptake of minimally invasive surgery and stereotactic body radiation therapy for early stage non-small cell lung cancer in the USA: an ecological study of secular trends using the National Cancer Database.

BMJ Open Respir Res 2020 May;7(1)

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Background: We aimed to assess the uptake of minimally invasive surgery (MIS) and stereotactic body radiation therapy (SBRT) among early stage (stage IA-IIB) non-small cell lung cancer (NSCLC) cases in the USA, and the rate of conversions from MIS to open surgery.

Materials And Methods: Data were obtained from the US National Cancer Database, a nationwide facility-based cancer registry capturing up to 70% of incident cancer cases in the USA. We included cases diagnosed with early stage (clinical stages IA-IIB) NSCLC between 2010 and 2014. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228566PMC

Characterisation of ICU sleep by a commercially available activity tracker and its agreement with patient-perceived sleep quality.

BMJ Open Respir Res 2020 Apr;7(1)

School of Pharmacy, Northeastern University, Boston, Massachusetts, USA.

Background: A low-cost, quantitative method to evaluate sleep in the intensive care unit (ICU) that is both feasible for routine clinical practice and reliable does not yet exist. We characterised nocturnal ICU sleep using a commercially available activity tracker and evaluated agreement between tracker-derived sleep data and patient-perceived sleep quality.

Patients And Methods: A prospective cohort study was performed in a 40-bed ICU at a community teaching hospital. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204814PMC

Side effects of acetazolamide: a systematic review and meta-analysis assessing overall risk and dose dependence.

BMJ Open Respir Res 2020 Apr;7(1)

Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, California, USA.

Introduction: Acetazolamide (AZM) is used for various conditions (eg, altitude sickness, sleep apnoea, glaucoma), but therapy is often limited by its side effect profile. Our objective was to estimate the risk of commonly reported side effects based on meta-analyses. We hypothesised that these risks are dose-dependent. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204833PMC

Non-tuberculous mycobacterial lung disease in patients with bronchiectasis: perceived risk, severity and guideline adherence in a European physician survey.

BMJ Open Respir Res 2020 Apr;7(1)

Insmed Inc, Bridgewater, New Jersey, USA.

Background: Patients with bronchiectasis are at increased risk of developing non-tuberculous mycobacteria lung disease (NTM-LD), and published guidelines recommend regular testing for NTM infection in this patient population.

Objective: This study aimed to survey physicians managing patients with bronchiectasis to understand the perceived risk of NTM to their patients, perceived disease severity and frequency of testing for NTM.

Methods: The study comprised an online survey of hospital-based physicians in the UK, Germany, Italy, France and the Netherlands. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204844PMC

British Thoracic Society guideline for the use of long-term macrolides in adults with respiratory disease.

BMJ Open Respir Res 2020 Apr;7(1)

Pharmacy, University College London, London, UK.

The full British Thoracic Society (BTS) guideline for the use of long-term macrolides in adults with respiratory disease is published in Thorax. The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204798PMC

Prognosis and causes of death of patients with acute exacerbation of fibrosing interstitial lung diseases.

BMJ Open Respir Res 2020 Apr;7(1)

Respiratory Medicine, Research Unit of Internal Medicine, University of Oulu, Oulu, Finland.

Background: The aim of this study was to compare the clinical characteristics, causes of death and factors impacting on the prognosis of patients with idiopathic pulmonary fibrosis (IPF) and other fibrosing interstitial lung disease (FILD) with a history of acute exacerbation (AE) of IPF or FILD.

Methods: Retrospective data of hospital treatment periods caused by AE-IPF and AE-FILD were collected from medical records. Clinical features and survival data of IPF and non-IPF cases were evaluated and compared. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254157PMC

Environmental impact of inhalers for respiratory diseases: decreasing the carbon footprint while preserving patient-tailored treatment.

BMJ Open Respir Res 2020 Mar;7(1)

Global Medical Affairs, Chiesi Farmaceutici SpA, Parma, Italy.

Patients with asthma and Chronic Obstructive Respiratory Disease (COPD) rely on three main device classes for inhalation therapy: metered-dose inhalers (MDIs), dry powder inhalers (DPIs) and soft-mist inhalers (SMIs). The carbon footprint (CF) of these inhalers differs with MDIs having a higher impact than DPIs and SMIs due to the propellant in MDIs. However, the certified CF of specific MDI products may differ significantly. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173981PMC

Influence of observer preferences and auscultatory skill on the choice of terms to describe lung sounds: a survey of staff physicians, residents and medical students.

BMJ Open Respir Res 2020 Mar;7(1)

Pulmonary Institute, Shaare Zedek Medical Center, Jerusalem, Jerusalem, Israel.

Background: In contrast with the technical progress of the stethoscope, lung sound terminology has remained confused, weakening the usefulness of auscultation. We examined how observer preferences regarding terminology and auscultatory skill influenced the choice of terms used to describe lung sounds.

Methods: Thirty-one staff physicians (SP), 65 residents (R) and 47 medical students (MS) spontaneously described the audio recordings of 5 lung sounds classified acoustically as: (1) normal breath sound; (2) wheezes; (3) crackles; (4) stridor and (5) pleural friction rub. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173982PMC

Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study.

BMJ Open Respir Res 2020 Mar;7(1)

Adult CF Unit, Liverpool Heart and Chest Hospital NHS Trust, Liverpool, UK.

Introduction: Dynamic chest radiography (DCR) uses novel, low-dose radiographic technology to capture images of the thoracic cavity while in motion. Pulmonary function testing is important in cystic fibrosis (CF). The tolerability, rapid acquisition and lower radiation and cost compared with CT imaging may make DCR a useful adjunct to current standards of care. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206905PMC

Randomised placebo-controlled cross-over study examining the role of anamorelin in mesothelioma (The ANTHEM study): rationale and protocol.

BMJ Open Respir Res 2020 Mar;7(1)

Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

Introduction: Cachexia is common in malignant mesothelioma (MM); half of patients have malnutrition and low skeletal muscle mass. Malnourished patients have worse quality of life (QoL). Weight loss is strongly associated with poor survival. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173983PMC

Using and implementing care bundles for patients with acute admission for COPD: qualitative study of healthcare professionals' experience in four hospitals in England.

BMJ Open Respir Res 2020 Mar;7(1)

Population Health Sciences, University of Bristol Faculty of Health Sciences, Bristol, UK

Background: Care bundles are sets of evidence-based interventions to improve quality of hospital care at admission and discharge. Within a wider multi-method evaluation of care bundles for adults with an emergency admission for acute exacerbations of chronic obstructive pulmonary disease, a qualitative study was conducted. The aim was to evaluate how bundles were used, and healthcare professionals' experiences of the impact of bundles on the process of care delivery. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173984PMC

Respiratory events associated with concomitant opioid and sedative use among Medicare beneficiaries with chronic obstructive pulmonary disease.

BMJ Open Respir Res 2020 Mar;7(1)

Pharmaceutical Health Services Research, University of Maryland Baltimore, Baltimore, Maryland, USA.

Background: Opioids and sedatives are commonly prescribed in chronic obstructive pulmonary disease (COPD) patients for symptoms of dyspnoea, pain, insomnia, depression and anxiety. Older adults are advised to avoid these medications due to increased adverse events, including respiratory events. This study examines respiratory event risks associated with concomitant opioid and sedative use compared with opioid use alone in older adults with COPD. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173985PMC

Ambient air pollution is associated with airway inflammation in older women: a nested cross-sectional analysis.

BMJ Open Respir Res 2020 Mar;7(1)

Environmental Epidemiology of Lung, Brain and Skin Aging, Leibniz Research Institute for Environmental Medicine, Dusseldorf, Nordrhein-Westfalen, Germany

Background: Air pollution is a risk factor for chronic obstructive pulmonary disease (COPD). Fraction of exhaled nitric oxide (FeNO) could be a useful biomarker for health effects of air pollutants. However, there were limited data from older populations with higher prevalence of COPD and other inflammatory conditions. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206912PMC

Maintaining quality of life in patients with chronic obstructive pulmonary disease (COPD) by extending the maintenance phase of community-based pulmonary rehabilitation: protocol for a randomised controlled trial (ComEx3 Study).

BMJ Open Respir Res 2020 Mar;7(1)

School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.

Introduction: Pulmonary rehabilitation is a core component of the treatment of people with chronic obstructive pulmonary disease (COPD); however, the benefits gained diminish in the ensuing months. The optimal strategy for maintaining the benefits is unclear with weekly supervised maintenance exercise programmes proposed as one strategy. However, the long-term future of maintenance programs is dependent on quality evidence. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206909PMC

Asthma control is associated with economic outcomes, work productivity and health-related quality of life in patients with asthma.

BMJ Open Respir Res 2020 Mar;7(1)

Department of Allergy, Kaiser Permanente Southern California Region, San Diego and Pasadena, California, USA.

Background: The objective of this analysis was to examine the association between asthma control (based on Asthma Control Test (ACT) responses) and healthcare resource utilisation (HRU), work productivity and health-related quality of life (HRQoL) among a nationwide sample of US adults with a self-reported diagnosis of asthma and without comorbid chronic obstructive pulmonary disease.

Methods: Data were obtained from the 2015 and 2016 self-administered, internet-based National Health and Wellness Surveys. Patients were grouped by ACT score (≤15: poorly controlled; 16-19: partly controlled; 20-25: well-controlled asthma). Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101043PMC

Age-stratified burden of pneumococcal community acquired pneumonia in hospitalised Canadian adults from 2010 to 2015.

BMJ Open Respir Res 2020 Mar;7(1)

Canadian Center for Vaccinology (CCfV), Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.

Background: In Canada, 13-valent pneumococcal conjugate vaccine (PCV13) is recommended in childhood, in individuals at high risk of invasive pneumococcal disease (IPD) and in healthy adults aged ≥65 years for protection against vaccine-type IPD and pneumococcal community-acquired pneumonia (pCAP). Since vaccine recommendations in Canada include both age-based and risk-based guidance, this study aimed to describe the burden of vaccine-preventable pCAP in hospitalised adults by age.

Methods: Surveillance for community-acquired pneumonia (CAP) in hospitalised adults was performed prospectively from 2010 to 2015. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078693PMC

The effects of sildenafil on ciliary beat frequency in patients with pulmonary non-tuberculous mycobacteria disease: phase I/II trial.

BMJ Open Respir Res 2020 Mar;7(1)

Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.

Rationale: Pulmonary non-tuberculous mycobacterial (PNTM) disease has increased over the past several decades, especially in older women. Abnormal mucociliary clearance and abnormal nasal nitric oxide (nNO) have been associated with PNTM disease in other patient cohorts. Mucociliary clearance can be affected by NO-cyclic guanosine monophosphate signalling and, therefore, modulation of the pathway may be possible with phosphodiesterase inhibitors such as sildenafil as a novel therapeutic approach. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069259PMC

'Scared to death' dyspnoea from the hospitalised patient's perspective.

BMJ Open Respir Res 2020 Mar;7(1)

Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Because dyspnoea is seldom experienced by healthy people, it can be hard for clinicians and researchers to comprehend the patient's experience. We collected patients' descriptions of dyspnoea in their own words during a parent study in which 156 hospitalised patients completed a quantitative multidimensional dyspnoea questionnaire. These volunteered comments describe the severity and wide range of experiences associated with dyspnoea and its impacts on a patients' life. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069254PMC

Novel measure of lung function for assessing disease activity in asthma.

BMJ Open Respir Res 2020 Mar;7(1)

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

Introduction: In asthma, lung function measures are often discordant with clinical features such as disease activity or control.

Methods: We investigated a novel technique that provides a measure (σCL) of unevenness (inhomogeneity) in lung inflation/deflation. In particular, we compared σCL with FEV% predicted (FEV%pred) as measures of disease activity in the asthmatic lung. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066624PMC

Experiences and views of patients, carers and healthcare professionals on using modems in domiciliary non-invasive ventilation (NIV): a qualitative study.

BMJ Open Respir Res 2020 Mar;7(1)

Thoracic Medicine, Royal Free London NHS Foundation Trust, London, UK.

Background: Advances in technology means that domiciliary non-invasive ventilation (NIV) devices can be remotely monitored via modems in patients' homes. Possible benefits and challenges of modem technology have yet to be established. This study explored the perspectives and experiences of patients, their carers and healthcare professionals (HCPs) on the addition of modem technology in managing home NIV. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066605PMC

Complications and discomfort after research bronchoscopy in the MicroCOPD study.

BMJ Open Respir Res 2020 Mar;7(1)

Department of Clinical Science, University of Bergen, Bergen, Norway.

Background: Data on discomfort and complications from research bronchoscopy in chronic obstructive pulmonary disease (COPD) and asthma is limited. We present complications and discomfort occurring within a week after bronchoscopy, and investigate personal and procedural risk factors.

Methods: 239 subjects with COPD, asthma or without lung disease underwent research bronchoscopies as part of a microbiome study of the lower airways (the MicroCOPD study). Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064136PMC

Feasibility and acceptability of introducing advance care planning on a thoracic medicine inpatient ward: an exploratory mixed method study.

BMJ Open Respir Res 2020 Feb;7(1)

Department of Clinical Medicine K1, University of Bergen, Bergen, Norway.

Background And Aims: Advance care planning (ACP) is communication about wishes and preferences for end-of-life care. ACP is not routinely used in any Norwegian hospitals. We performed a pilot study (2014-2017) introducing ACP on a thoracic medicine ward in Norway. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047484PMC
February 2020

Early NIV is associated with accelerated lung function decline in Duchenne muscular dystrophy treated with glucocorticosteroids.

BMJ Open Respir Res 2020 Feb;7(1)

Respiratory Medicine, Children's Health Queensland Hospital and Health Service, South Birsbane, Queensland, Australia

Background: Use of non-invasive ventilation (NIV) in adolescents with Duchenne muscular dystrophy (DMD) has increased with concomitant extended survival.

Aim: To describe lung function (LF) changes with NIV in adolescents with DMD and to assess differences between and subjects.

Method: A retrospective cohort of adolescents with DMD initiating NIV over 10 years was conducted. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047482PMC
February 2020

Correlation between biomarkers of exposure, effect and potential harm in the urine of electronic cigarette users.

BMJ Open Respir Res 2020 Feb;7(1)

Department of Cell, Molecular, and Developmental Biology, University of California Riverside, Riverside, California, USA

Objectives: To determine if urinary biomarkers of effect and potential harm are elevated in electronic cigarette users compared with non-smokers and if elevation correlates with increased concentrations of metals in urine.

Study Design And Setting: This was a cross-sectional study of biomarkers of exposure, effect and potential harm in urine from non-smokers (n=20), electronic cigarette users (n=20) and cigarette smokers (n=13). Participant's screening and urine collection were performed at the Roswell Park Comprehensive Cancer Center, and biomarker analysis and metal analysis were performed at the University of California, Riverside. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047495PMC
February 2020

Effect of acute respiratory infections in infancy on pulmonary function test at 3 years of age: a prospective birth cohort study.

BMJ Open Respir Res 2020 Feb;7(1)

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, Delhi, India

Introduction: Acute respiratory infections (ARIs) in infancy may have a long-term impact on the developing respiratory system. We planned a prospective cohort study to determine the impact of ARI during infancy on the pulmonary function test indices at 3 years of age.

Methods: A cohort of normal, full-term newborns were followed up 6 monthly and during ARI episodes. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047475PMC
February 2020

Influence of age on real-life effects of doxycycline for acute exacerbations among COPD outpatients: a population-based cohort study.

BMJ Open Respir Res 2020 Feb;7(1)

Department of PharmacoTherapy, Epidemiology & Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.

Introduction: Although bacteria contribute significantly to acute exacerbations of chronic obstructive pulmonary disease (AECOPD), the added value of antibiotics remains controversial, especially in outpatient settings. Age may affect antibiotic effectiveness, but real-world evidence is lacking. We aimed to assess the influence of age on the effectiveness of doxycycline for AECOPD. Read More

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http://dx.doi.org/10.1136/bmjresp-2019-000535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047485PMC
February 2020

Randomised clinical trial to determine the safety of quercetin supplementation in patients with chronic obstructive pulmonary disease.

BMJ Open Respir Res 2020 Feb;7(1)

Thoracic Medicine and Surgery, Temple University Medical School, Philadelphia, Pennsylvania, USA

Introduction: Quercetin is a plant flavonoid and has potent antioxidant and anti-inflammatory properties. In a preclinical model of chronic obstructive pulmonary disease (COPD), quercetin reduced markers of both oxidative stress and lung inflammation and also reduced rhinovirus-induced progression of lung disease. Although quercetin appears to be an attractive natural alternative to manage COPD, the safety of quercetin supplementation in this population is unknown. Read More

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http://dx.doi.org/10.1136/bmjresp-2018-000392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047491PMC
February 2020