171 results match your criteria BMJ open ophthalmology[Journal]


Eyelid skin trichilemmoma and underlying local malignancy: is an aggressive treatment necessary?

BMJ Open Ophthalmol 2020 25;5(1):e000513. Epub 2020 Jun 25.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.

Objective: Trichilemmoma is a benign tumour derived from the outer root sheath of hair follicles. Trichilemmoma can be associated with basal cell carcinoma (BCC), either as a collision lesion or from malignant transformation. This study evaluates malignancy associated with eyelid trichilemmoma and principles of treatment. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319780PMC

Economic modelling of immediately sequential bilateral cataract surgery (ISBCS) in the National Health Service based on possible improvements in surgical efficiency.

BMJ Open Ophthalmol 2020 25;5(1):e000426. Epub 2020 Jun 25.

Guy's and Saint Thomas' NHS Foundation Trust, London, UK.

Objective: To test a hypothesis that operating room (OR) productivity in the National Health Service (NHS) can be improved with the introduction of immediately sequential bilateral cataract surgery (ISBCS).

Methods And Analysis: Previously published time and motion data of 140 unilateral cataract surgeries conducted at five different NHS locations were reanalysed to construct a hypothetical model where only ISBCS (±one unilateral case) were conducted while maintaining time durations of all key tasks previously studied. Possible time efficiency savings were calculated for the ISBCS model and percentage increases in numbers of eyes operated per 4-hour theatre session calculated. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319779PMC

Paediatric ocular adnexal lymphoma: a population-based analysis.

BMJ Open Ophthalmol 2020 21;5(1):e000483. Epub 2020 Jun 21.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

Objective: To investigate the incidence, clinicopathological characteristics and survival of ocular adnexal lymphoma (OAL) in the paediatric population.

Methods And Analysis: In this retrospective case series, the Surveillance, Epidemiology and End Results database was accessed to identify individuals with OAL ≤18 years of age, diagnosed between 1973 and 2015. OAL located in the eyelid, conjunctiva, lacrimal apparatus and orbit were included. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312335PMC

Spatial and spatio-temporal statistical analyses of retinal images: a review of methods and applications.

BMJ Open Ophthalmol 2020 28;5(1):e000479. Epub 2020 May 28.

Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, a member of Liverpool Health Partners, Liverpool, UK.

Background: Clinical research and management of retinal diseases greatly depend on the interpretation of retinal images and often longitudinally collected images. Retinal images provide context for spatial data, namely the location of specific pathologies within the retina. Longitudinally collected images can show how clinical events at one point can affect the retina over time. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264837PMC

Retinal arteriolar oxygen saturation predicts the need for intravitreal aflibercept in patients with diabetic macular oedema.

BMJ Open Ophthalmol 2020 27;5(1):e000382. Epub 2020 May 27.

Department of Ophthalmology, Odense University Hospital, Odense, Denmark.

Objective: Given the increasing burden of repetitive intravitreal injections in diabetic macular oedema (DMO) treatment, non-invasive markers of treatment outcome are needed. Hence, we aimed to examine retinal oximetry parameters as markers of need for intravitreal aflibercept in patients with DMO.

Methods: This study was based on data from a 12-month clinical trial including 35 eyes of 25 patients with centre involving DMO. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259848PMC

Factors influencing the decision-making of carers of children with bilateral cataract in Nepal.

BMJ Open Ophthalmol 2020 6;5(1):e000422. Epub 2020 Apr 6.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, International Centre for Eye Health, London, UK.

Objectives: Two hundred thousand children worldwide are blind from cataract. Late presentation for surgery resulting in poor visual outcomes is a problem globally. We aimed to explore the reasons why children are not brought earlier for surgery in Nepal. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254144PMC

Fluocinolone acetonide (0.19 mg) intravitreal implant reduces treatment burden and improves practice resource utilisation for patients with diabetic macular oedema.

BMJ Open Ophthalmol 2020 8;5(1):e000416. Epub 2020 Apr 8.

Retina, Cincinnati Eye Institute, Cincinnati, Ohio, United States.

Objective: Patients with diabetic macular oedema (DME) are known to have significantly greater medical treatment burden than patients with non-DME. Frequent injections and office visits can have a substantial impact on patient adherence and quality of life. This analysis assesses the impact of the 0. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254114PMC

Impact of intravitreal aflibercept dosing regimens in treatment-naïve patients with neovascular age-related macular degeneration in routine clinical practice in France: results from the RAINBOW study.

BMJ Open Ophthalmol 2020 6;5(1):e000377. Epub 2020 Apr 6.

Centre d'Imagerie et de Laser, Paris, France.

Objective: To evaluate 12-month outcomes in treatment-naïve patients with neovascular (wet) age-related macular degeneration (AMD) stratified by intravitreal aflibercept (IVT-AFL) regimen.

Methods And Analysis: Patients included in the 12-month interim analysis of Real life of intravitreal Aflibercept In FraNce: oBservatiOnal Study in Wet AMD (RAINBOW), a 4-year, ongoing observational study conducted in France, were stratified by IVT-AFL dosing regimen. Safety (n=593) and effectiveness (n=428) data were analysed. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254134PMC

Selective laser trabeculoplasty (SLT) performed by optometrists for patients with glaucoma and ocular hypertension: a scoping review protocol.

BMJ Open Ophthalmol 2020 25;5(1):e000438. Epub 2020 May 25.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Introduction: In the UK, the National Institute for Health and Clinical Excellence are amending guidelines to support use of selective laser trabeculoplasty (SLT) as a first-line treatment for patients with glaucoma and ocular hypertension. The procedure is quick, effective in lowering intraocular pressure, cost-effective for the National Health Service and offers an equivalent safety profile to other therapies. The procedure is typically performed by an ophthalmologist; however, there is potential for suitably trained non-medical professionals to deliver the therapy. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252989PMC

Complement factors and reticular pseudodrusen in intermediate age-related macular degeneration staged by multimodal imaging.

BMJ Open Ophthalmol 2020 14;5(1):e000361. Epub 2020 Jan 14.

Department of Ophthalmology, University of Colorado Denver School of Medicine, Aurora, Colorado, USA.

Objective: Systemic activation of the complement system in intermediate age-related macular degeneration (AMD) is understudied. Moreover, links between the presence of reticular pseudodrusen (RPD) and systemic complement dysregulation have not been studied. The aim of this study was to determine if there is a difference in plasma complement factor levels in intermediate AMD compared with controls, and if complement levels are related to the presence of RPD. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254108PMC
January 2020

Ophthalmology practice during the COVID-19 pandemic.

BMJ Open Ophthalmol 2020 19;5(1):e000487. Epub 2020 Apr 19.

Ophthalmology Department, Hadassah Medical Center, Jerusalem, Israel.

Objective: To present an established practice protocol for safe and effective hospital-setting ophthalmic practice during the coronavirus disease 2019 (COVID-19) pandemic.

Methods And Analysis: Literature was reviewed to identify articles relevant to COVID-19 pandemic and ophthalmology. The following keywords were used: COVID-19, SARS-CoV-2 and telemedicine, combined with eye, ophthalmology, conjunctivitis and tears. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222613PMC

Role of ethnicity and socioeconomic status (SES) in the presentation of retinoblastoma: findings from the UK.

BMJ Open Ophthalmol 2020 15;5(1):e000415. Epub 2020 May 15.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Background: The relationship between the ethnic background or socioeconomic status (SES) and late retinoblastoma (Rb) presentation in the UK is unclear. We aimed to investigate if such correlations exist in a cohort of non-familial Rb cases.

Methods: A cross-sectional study based at the two centres providing Rb care in the UK. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232618PMC

Dexamethasone intracameral drug-delivery suspension for inflammation associated with vitreoretinal surgery.

Authors:
Daniel F Kiernan

BMJ Open Ophthalmol 2020 5;5(1):e000491. Epub 2020 May 5.

Ophthalmology, Ophthalmic Consultants of Long Island, Rockville Centre, New York, USA.

Objective: To evaluate the efficacy of an anterior chamber intracameral dexamethasone (ICD) drug-delivery suspension (Dexycu; EyePoint Pharmaceuticals, Watertown, Massachusetts, USA) providing sustained release of medication following a single application for the treatment of postoperative inflammation in patients undergoing vitreoretinal surgery compared to daily postoperative treatment with topical corticosteroids for up to 1 month.

Methods And Analysis: Retrospective case-matched comparison of patients undergoing initial vitreoretinal surgery by a single surgeon. Patients had a preoperative best-corrected visual acuity of 20/20 to light perception and a variety of vitreoretinal pathologies. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228554PMC

Advanced late-onset retinitis pigmentosa with dominant-acting D477G RPE65 mutation is responsive to oral synthetic retinoid therapy.

BMJ Open Ophthalmol 2020 5;5(1):e000462. Epub 2020 May 5.

Institute of Genetics, University of Dublin, Trinity College, Dublin, Ireland.

Objectives: No therapeutic interventions are currently available for autosomal dominant retinitis pigmentosa (adRP). An RPE65 Asp477Gly transition associates with late-onset adRP, reduced RPE65 enzymatic activity being one feature associated with this dominant variant. Our objective: to assess whether in a proof-of-concept study, oral synthetic 9 -retinyl acetate therapy improves vision in such advanced disease. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228561PMC

Use of the King-Devick Variable Color Contrast Sensitivity Chart to differentiate stages of age-related macular degeneration.

BMJ Open Ophthalmol 2020 12;5(1):e000451. Epub 2020 May 12.

Elman Retina Group, Rosedale, Maryland, USA.

Objective: This study aimed to determine which colour contrast sensitivity differences exist in early to advanced age-related macular degeneration (AMD) and examine the potential utility of the King-Devick Variable Color Contrast Sensitivity Chart in detecting AMD severity.

Methods And Analysis: A total of 85 participants (144 total eyes) were recruited from multiple clinical practices and enrolled in the study. The control group consisted of 57 healthy eyes. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228553PMC

HbA1c as a predictor for response of bevacizumab in diabetic macular oedema.

BMJ Open Ophthalmol 2020 12;5(1):e000449. Epub 2020 May 12.

Department of Retina, B.P. Koirala Lions Center for Ophthalmic Studies, Institute of Medicine, Kathmandu, Nepal.

Objective: To study the influence of glycosylated haemoglobin (HbA1c) on response of bevacizumab in patients with diabetic macular oedema.

Methods And Analysis: A total of 37 eyes of 37 patients with vision loss due to diabetic macular oedema treated with bevacizumab were included in this study. Participants received monthly intravitreal bevacizumab (0. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228525PMC

Orthokeratology with increased compression factor (OKIC): study design and preliminary results.

BMJ Open Ophthalmol 2020 4;5(1):e000345. Epub 2020 May 4.

School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.

Objective: To present the study design and the baseline data of a prospective cohort study investigating the safety, refractive correction and effectiveness of myopia control in subjects fitted with orthokeratology (ortho-k) lenses of different compression factors.

Methods And Analysis: This study is a 2-year longitudinal, double-masked, partially randomised study. Myopic children aged between 6 and 10 years are recruited and they may choose to participate in either the ortho-k or spectacle-wearing group. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223350PMC

Progression to blindness in 20 years among patients with glaucomatous visual field loss in a tertiary hospital in the Philippines.

BMJ Open Ophthalmol 2020 26;5(1):e000424. Epub 2020 Apr 26.

Eye Institute, St. Luke's Medical Center, Quezon City, Philippines.

Objective: To determine visual field (VF) rates of change among patients with glaucomatous VF loss and proportion of those becoming blind based on residual life expectancy and factors associated with fast progression.

Methods And Analysis: This was a retrospective study of the VFs of patients with glaucomatous VF defects in at least one eye. Baseline and final VFs were reviewed. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213877PMC

Vitrectomy for endophthalmitis: 5-year study of outcomes and complications.

BMJ Open Ophthalmol 2020 24;5(1):e000423. Epub 2020 Mar 24.

Department of Vitreoretinal Surgery, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Background/aims: To analyse the complications and outcomes of vitrectomy surgery for endophthalmitis.

Methods: This was a retrospective case series. All cases that underwent 23-gauge vitrectomy surgery for endophthalmitis at a tertiary centre between 1 February 2013 and 1 February 2018 were included. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103804PMC

A comparison of the 1-year surgical outcomes of trabeculotomy and microhook trabeculotomy using propensity score analysis.

BMJ Open Ophthalmol 2020 5;5(1):e000446. Epub 2020 Mar 5.

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.

Objective: To compare the 1-year outcomes of trabeculotomy ( TLO) and trabeculotomy using a microhook ( TLO) for glaucoma patients using propensity score analysis.

Methods And Analysis: The medical charts of 65 consecutive patients who underwent TLO and those of 69 patients who underwent TLO were reviewed. Logistic regression analysis was conducted to calculate the propensity score using 1:1 matched analysis, which indicates the likelihood of surgical success at 12 months. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059522PMC

Outcomes of pars plana vitrectomy with subretinal tissue plasminogen activator injection and pneumatic displacement of fovea-involving submacular haemorrhage.

BMJ Open Ophthalmol 2020 16;5(1):e000394. Epub 2020 Mar 16.

New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.

Objective: Fovea-involving subretinal haemorrhage is challenging to manage with uncertain visual outcomes. We reviewed outcomes of patients with fovea-involving macular haemorrhage treated with pars plana vitrectomy (PPV) and subretinal tissue plasminogen activator (tPA) with pneumatic displacement.

Methods And Analysis: This is a retrospective interventional case series. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076260PMC

Prevalence and associated risk factors of diabetic retinopathy and macular oedema in patients recently diagnosed with type 2 diabetes.

BMJ Open Ophthalmol 2020 10;5(1):e000304. Epub 2020 Mar 10.

Departamento de Epidemiología Ocular y Salud Visual, Instituto de Oftalmología Fundación Conde de Valenciana IAP, Ciudad de México, México.

Objective: To determine the prevalence of diabetic retinopathy (DR) and diabetic macular oedema (DME) and their associated risk factors in patients recently diagnosed with type 2 diabetes.

Methods And Analysis: We carried out a cross-sectional study from April 2014 to August 2017. We included patients aged ≥18 years. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066603PMC

Endocannabinoids in aqueous humour of patients with or without diabetes.

BMJ Open Ophthalmol 2020 17;5(1):e000425. Epub 2020 Feb 17.

Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Derby, Derbyshire, UK.

Objective: The primary aim was to determine endocannabinoid (EC) concentrations of 2-arachidonoylglycerol (2-AG), oleoylethanolamine (OEA), palmitoylethanolamine (PEA) and anandamide (AEA) in the aqueous humour of patients, and to investigate any differences in gender and diabetic or ocular disease status.

Methods And Analysis: Adult participants (age >18 years) listed for a routine cataract surgery were recruited. For patients with diabetes, results from their most recent retinopathy grading were recorded. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045208PMC
February 2020

Comparison of glistenings formation and their effect on forward light scatter between the Acrysof SN60WF and Eternity Natural Uni NW-60 intraocular lenses.

BMJ Open Ophthalmol 2020 12;5(1):e000399. Epub 2020 Feb 12.

Centre for Applied Vision Research, City University, London, UK.

Aims: To compare the characteristics of glistenings and forward light scatter between the Alcon Acrysof SN60WF and Santen Eternity Natural Uni NW-60 intraocular lenses (IOLs).

Methods: Five Acrysof SN60WF and five Eternity Natural Uni NW-60 IOLs were studied. All IOLs were single piece blue blockers with the same dioptric power (20D) and optic diameter (6. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044831PMC
February 2020

Does the sampling instrument influence corneal culture outcome in patients with infectious keratitis? A retrospective study comparing cotton tipped applicator with knife blade.

BMJ Open Ophthalmol 2020 4;5(1):e000363. Epub 2020 Feb 4.

Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, SE 70182, Örebro, Sweden.

Objective: This study aimed to compare the efficacy of a cotton tipped applicator and a knife blade in obtaining corneal samples in patients with infectious keratitis.

Methods And Analysis: This is a retrospective cohort study of patients with suspected infectious keratitis during 2004-2014. Samples for corneal culture were obtained by a cotton tipped applicator and a knife blade, and directly inoculated on GC agar, blood agar and Sabouraud agar. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044929PMC
February 2020

Five-year follow-up outcomes after Descemet's stripping automated endothelial keratoplasty: a retrospective study.

BMJ Open Ophthalmol 2020 29;5(1):e000354. Epub 2020 Jan 29.

Ophthalmology, Baptist Eye Institute, Kyoto, Japan.

Objective: To assess graft survival and endothelial cell density (ECD) over a 5-year follow-up period after Descemet's stripping automated endothelial keratoplasty (DSAEK).

Methods And Analysis: This retrospective study involved 130 eyes of 130 consecutive patients with Fuchs endothelial corneal dystrophy (FECD), non-FECD bullous keratopathy (BK) (non-FECD) or BK post-trabeculectomy or tube-shunt surgery (glaucoma with bleb) who underwent DSAEK between August 2007 and January 2012 and were followed for more than 5 years postoperatively. Patients with previous keratoplasty, graft suture failure, primary graft failure, postoperative endophthalmitis and ocular infection were excluded. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045206PMC
January 2020

Assessing full thickness oral mucosal grafting: complications and postoperative outcomes in a broad collective of patients.

BMJ Open Ophthalmol 2020 10;5(1):e000337. Epub 2020 Feb 10.

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Conjunctival defects can be repaired with several mucosal tissues. The simplicity of harvesting oral mucosa and its wide availability makes it the preferred graft tissue for all indications requiring mucosal grafting. Through analysing the postsurgical outcomes and rate of revisions, this study explores the suitability of oral mucosa grafts, depending on the initial diagnosis. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045019PMC
February 2020

Ocular side effects of antirheumatic medications: a qualitative review.

BMJ Open Ophthalmol 2020 7;5(1):e000331. Epub 2020 Jan 7.

Division of Rheumatology and Immunology, Ohio State University, Columbus, Ohio, USA.

Topic: This paper reviews the ocular side effects of medications used in the treatment of rheumatological conditions.

Clinical Relevance: Rheumatic diseases are inflammatory conditions that may affect the skin, blood vessels, joints, muscles and internal organs. Immunosuppressive agents are often used as treatment and while powerful, they carry side effects and toxicities that need careful monitoring. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045116PMC
January 2020

Interactive online survey raises awareness about cornea donation.

BMJ Open Ophthalmol 2020 4;5(1):e000285. Epub 2020 Feb 4.

Cornea Service, Athens Vision Eye Institute, Athens, Greece.

Objective: To assess the impact of a 5 min interactive online survey on raising awareness about cornea donation and willingness to become a donor.

Methods: An interactive online questionnaire was used to collect information regarding awareness, perceptions and attitudes towards cornea donation and to educate the participants about the process and value of cornea donation. Willingness to become a cornea donor was assessed at the beginning and the end of the survey. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045065PMC
February 2020

Effect of fluocinolone acetonide 0.2 μg/day implant on the decision to drive in patients with diabetic macular oedema: a report from the FAME study.

BMJ Open Ophthalmol 2019 15;4(1):e000405. Epub 2019 Dec 15.

Department of Ophthalmology, Retina Associates of Florida, PA, Tampa, Florida, USA.

Objective: This study aimed to determine whether treatment with the 0.2 µg/day fluocinolone acetone implant (FAc; ILUVIEN, Alimera Sciences) and the associated improvements in best-corrected visual acuity (BCVA) and central subfield thickness (CST) demonstrated in the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) study have an impact on the patient's decision to drive as measured by the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25).

Methods: This was a post hoc analysis of up to 3 years of NEI-VFQ-25 data collected during the phase III FAME trial. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936565PMC
December 2019

Current and upcoming anti-VEGF therapies and dosing strategies for the treatment of neovascular AMD: a comparative review.

BMJ Open Ophthalmol 2019 15;4(1):e000398. Epub 2019 Dec 15.

Ophthalmology and Visual Sciences, University of Chicago, Chicago, Illinois, USA.

Age-related macular degeneration is the leading cause of vision loss in the developed world, with the expected number of affected elderly individuals reaching 17.8 million. Antivascular endothelial growth factor (anti-VEGF) injection therapy has been instrumental in treating a disease process that was previously thought to be untreatable. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936465PMC
December 2019

Intravitreal bevacizumab improves the clearance of vitreous haemorrhage and visual outcomes in patients with proliferative diabetic retinopathy.

BMJ Open Ophthalmol 2019 10;4(1):e000390. Epub 2019 Dec 10.

Department of Ophthalmology, University of Oulu and Oulu University Hospital, Oulu, Finland.

Objective: To evaluate the occurrence of vitreous haemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR) and the efficacy of intravitreal bevacizumab (IVB) for VH in 5-year real-life data.

Methods And Analysis: 850 adult patients with type 1 (T1D) or type 2 diabetes (T2D) with PDR were screened for VH. The effect of IVB was evaluated by the clearage of VH and the change in best corrected visual acuity (BCVA). Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936487PMC
December 2019

Changes in the OCT angiographic appearance of type 1 and type 2 CNV in exudative AMD during anti-VEGF treatment.

BMJ Open Ophthalmol 2019 10;4(1):e000369. Epub 2019 Dec 10.

Department of Ophthalmology, St. Franziskus Hospital Münster, Münster, Germany.

Objective: Optical coherence tomography angiography (OCT-A) enables detailed visualisation of the vascular structure of choroidal neovascularisation (CNV). The aim of this study was to determine whether mathematically ascertained OCT-A vascular parameters of type 1 and type 2 CNV in exudative age-related macular degeneration (AMD) change during antivascular endothelial growth factor (anti-VEGF) treatment. The OCT-A vascular parameters were also compared with previously obtained activity parameters (fluid distribution on spectral domain OCT (SD-OCT)) to establish whether they could potentially be used as further 'activity parameters' for assessment of anti-VEGF treatment. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936421PMC
December 2019

Comparing the needs and preferences of patients with moderate and severe dry eye symptoms across four countries.

BMJ Open Ophthalmol 2019 15;4(1):e000360. Epub 2019 Dec 15.

Global Patient Access, Novartis Pharma AG, Basel, Switzerland.

Background/aims: Understanding patients' perspectives of their disease can inform drug development and treatment decisions. In this study, we compared the preferences and needs of patients with moderate and severe dry eye symptoms from four different countries.

Methods: A quantitative questionnaire was developed based on the self-explicated conjoint methodology and was administered to 160 patients with moderate or severe dry eye disease (DED) from Australia, Germany, UK and the USA. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936582PMC
December 2019

Association between antenatal blood pressure and 5-year postpartum retinal arteriolar structural and functional changes.

BMJ Open Ophthalmol 2019 11;4(1):e000355. Epub 2019 Dec 11.

Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Objective: Studies have shown that hypertensive disorders of pregnancy (HDP) are associated with both postpartum retinal microvascular changes and cardiovascular (CV) risks. However, the underlying mechanism of HDP transitioning to microvascular and macrovascular changes remains unknown, due to the interaction between microvasculature and CV risks. In this study, we examined whether associations between antenatal systolic blood pressure (SBP) and postpartum retinal arteriolar changes are independent of postpartum CV risks. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936440PMC
December 2019

The impact of microbial keratitis on quality of life in Uganda.

BMJ Open Ophthalmol 2019 23;4(1):e000351. Epub 2019 Dec 23.

Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK.

Background: Microbial keratitis (MK) is a frequent cause of sight loss in sub-Saharan Africa. However, no studies have formally measured its impact on quality of life (QoL) in this context.

Methods: As part of a nested case-control design for risk factors of MK, we recruited patients presenting with MK at two eye units in Southern Uganda between December 2016 and March 2018 and unaffected individuals, individually matched for sex, age and location. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936408PMC
December 2019

Role of advanced technology in the detection of sight-threatening eye disease in a UK community setting.

BMJ Open Ophthalmol 2019 4;4(1):e000347. Epub 2019 Dec 4.

Applied Vision Research Centre, School of Health Sciences, City, University of London, London, UK.

Background/aims: To determine the performance of combinations of structural and functional screening tests in detecting sight-threatening eye disease in a cohort of elderly subjects recruited from primary care.

Methods: 505 subjects aged ≥60 years underwent frequency doubling technology (FDT) perimetry, iVue optical coherence tomography (iWellness and peripapillary retinal nerve fibre layer (RNFL) scans) and intraocular pressure with the Ocular Response Analyzer, all performed by an ophthalmic technician. The reference standard was a full ophthalmic examination by an experienced clinician who was masked to the index test results. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936448PMC
December 2019

Defining the needs and preferences of patients with dry eye disease.

BMJ Open Ophthalmol 2019 5;4(1):e000315. Epub 2019 Dec 5.

Global Patient Access, Novartis Pharma, Basel, Switzerland.

Objective: Dry eye disease is a multifactorial chronic disease, leading to ocular discomfort and visual disturbance with a substantial impact on quality of life. Therefore, the patient's perspective should be taken into account early in the drug development process. We have developed a step-by-step methodology based on the self-explicated conjoint approach to assess the needs and preferences of patients with moderate-to-severe dry eye disease. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936476PMC
December 2019

Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration.

BMJ Open Ophthalmol 2019 17;4(1):e000273. Epub 2019 Dec 17.

Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium.

Objective: Age-related macular degeneration (ARMD) is a leading cause of visual impairment. Intravitreal injections of anti-vascular endothelial growth factor (VEGF) are the standard treatment for wet ARMD. There is however, variability in patient responses, suggesting patient-specific factors influencing drug efficacy. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936450PMC
December 2019

Kinetic visual acuity is correlated with functional visual acuity at higher speeds.

BMJ Open Ophthalmol 2019 19;4(1):e000383. Epub 2019 Nov 19.

Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Objective: To measure the kinetic visual acuity (KVA) which is the ability to identify approaching objects and the functional visual acuity (FVA) which is continuous VA during 1 min under binocular and monocular condition (non-dominant eye shielding) for healthy subjects, and related ocular parameters to explore their correlation and implication in aspect of integrated visual function.

Methods: The mean age of the 28 participants was 38.6±8. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882549PMC
November 2019

Long-term clinical outcomes of keratoplasty using gamma-irradiated corneal lenticules.

BMJ Open Ophthalmol 2019 10;4(1):e000396. Epub 2019 Nov 10.

Cornea and External Diseases, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Objective: To report long-term clinical outcomes of gamma-irradiated corneal lenticules in partial and full-thickness keratoplasty.

Methods And Analysis: This multicentre, retrospective case series includes 23 patients who underwent surgery at three centres (India, Guatemala, and USA) between May 2009 and March 2018. The main outcome measures were epithelialization and retention for therapeutic keratoplasty and best spectacle-corrected visual acuity (BSCVA) for optical keratoplasty. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861079PMC
November 2019

Systematic review of differential methylation in rare ophthalmic diseases.

BMJ Open Ophthalmol 2019 13;4(1):e000342. Epub 2019 Nov 13.

Centre for Public Health, Institute of Clinical Sciences B, Royal Victoria Hospital, Queen's University Belfast School of Medicine, Dentistry and Biomedical Sciences, Belfast, UK.

Rare ophthalmic diseases have a devastating impact on a patient's vision and consequently negatively affect their independence, ability to work and overall quality of life. Methylation is an important emerging biomarker of disease and may improve understanding of rare ophthalmic disorders. This systematic review sought to identify and evaluate literature on methylation and rare ophthalmic disease. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861117PMC
November 2019

Omega-3 fatty acids supplementation protects the retina from age-associated degeneration in aged C57BL/6J mice.

BMJ Open Ophthalmol 2019 10;4(1):e000326. Epub 2019 Nov 10.

Ophthalmos Research and Educational Institute, Nicosia, Cyprus.

Objective: To evaluate the therapeutic effects of omega-3 (ω3) fatty acids in the retina of aged mice when the blood arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio is maintained between 1.0 and 1.5. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861077PMC
November 2019

Characterisation of vascular changes in different stages of Stargardt disease using double swept-source optical coherence tomography angiography.

BMJ Open Ophthalmol 2019 2;4(1):e000318. Epub 2019 Nov 2.

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objective: To describe vascular changes in different stages of Stargardt disease (STGD) via double swept-source optical coherence tomography angiography.

Methods And Analysis: Prospective, cross-sectional case-control study. Twenty-three patients (45 eyes) with ABCA4 mutations graded according to the Fishman STGD classification and 23 controls (23 eyes) were included. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861074PMC
November 2019

Management of IgG4-related orbital disease: when not in doubt, cut it out?

BMJ Open Ophthalmol 2019 18;4(1):e000401. Epub 2019 Oct 18.

Division of Facial Cosmetic & Reconstructive Surgery, Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1136/bmjophth-2019-000401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830463PMC
October 2019

Clinically meaningful visual improvements and predictors of early vision gains with ranibizumab for diabetic macular oedema.

BMJ Open Ophthalmol 2019 22;4(1):e000335. Epub 2019 Oct 22.

Genentech, Inc, South San Francisco, California, USA.

Objective: To determine the time to first clinically meaningful improvement in best-corrected visual acuity (BCVA) in patients treated with ranibizumab for diabetic macular oedema (DME) and identify predictors of early visual improvement.

Methods And Analysis: We retrospectively analysed the phase III RIDE (NCT00473382) and RISE (NCT00473330) trials, in which 759 patients with DME were randomised to monthly intravitreal ranibizumab 0.3 mg (n=250), ranibizumab 0. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830470PMC
October 2019

Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey.

BMJ Open Ophthalmol 2019 30;4(1):e000276. Epub 2019 Oct 30.

Health Psychology Research Ltd, Royal Holloway University of London, Egham, UK.

Objectives: To investigate whether people with age-related macular degeneration (AMD) are able to self-detect symptoms and, if so, what symptoms they experience, from whom they first seek help, whether help is sought within the 1 week recommended by the Royal College of Ophthalmologists' guidelines and reasons for any delay.

Methods And Analysis: A retrospective, cross-sectional survey design. Postal surveys were sent to 4000 members of the UK Macular Society. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830468PMC
October 2019

Clinical and genomic features of adult and paediatric acute leukaemias with ophthalmic manifestations.

BMJ Open Ophthalmol 2019 3;4(1):e000362. Epub 2019 Oct 3.

Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Objective: To describe the clinicopathological and genomic features of nine patients with primary and secondary orbital/ocular manifestations of leukaemia.

Methods: All orbital/ocular leukaemic specimens from 1980 to 2009 were collected from the Danish Register of Pathology. In six cases, medical records and formalin-fixed, paraffin-embedded blocks were available. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797369PMC
October 2019
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Patient-reported outcome measures in the management of neovascular age-related macular degeneration: a 1-year prospective study.

BMJ Open Ophthalmol 2019 3;4(1):e000353. Epub 2019 Oct 3.

Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.

Objective: To prospectively explore the following patient-reported outcome measures (PROMs) in the management of neovascular age-related macular degeneration (nAMD): (1) self-reported visual function, (2) symptom-state, (3) general-health and (4) satisfaction of treatment.

Methods And Analysis: Corresponding to the four PROMs, participants responded to the following questionnaires: (1) National Eye Institute Visual-Functioning-Questionnaire (NEI-VFQ-25), (2) Patient-Acceptable-Symptom-Status (PASS 5), (3) EuroQol-Group-Questionnaire (EQ-5D-3L) and (4) Dimensions of Importance in Treatment of nAMD (DITAMD). Data were collected at baseline and after 3, 6 and 12 months of intravitreal antivascular endothelial growth factor treatment. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797267PMC
October 2019

Impact of the Manchester Glaucoma Enhanced Referral Scheme on NHS costs.

BMJ Open Ophthalmol 2019 30;4(1):e000278. Epub 2019 Sep 30.

Manchester Royal Eye Hospital and Manchester Academic Health Sciences Centre, Manchester University NHS Foundation Trust Manchester, Manchester, UK.

Objectives: Glaucoma filtering schemes such as the Manchester Glaucoma Enhanced Referral Scheme (GERS) aim to reduce the number of false positive cases referred to Hospital Eye Services. Such schemes can also have wider system benefits, as they may reduce waiting times for other patients. However, previous studies of the cost consequences and wider system benefits of glaucoma filtering schemes are inconclusive. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797377PMC
September 2019
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