82 results match your criteria BMJ open ophthalmology[Journal]


Five-year outcomes of retinal vein occlusion treated with vascular endothelial growth factor inhibitors.

BMJ Open Ophthalmol 2019 29;4(1):e000249. Epub 2019 Mar 29.

Sydney Institute of Vision Science, Sydney, New South Wales, Australia.

Purpose: Report 5-year outcomes of patients receiving anti-vascular endothelial growth factor (VEGF) for the treatment of macular oedema secondary to retinal vein occlusion (RVO.

Methods: Retrospective review of eyes with RVO which initiated anti-VEGF treatment. Data including age, gender, visual acuity (VA) and injection numbers were obtained from medical records. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440600PMC

Surgical management of intermittent exotropia: do we have an answer for all?

BMJ Open Ophthalmol 2019 8;4(1):e000243. Epub 2019 Mar 8.

Child Sight Institute, Jasti V Ramanamma Children's Eye Care Centre, L V Prasad Eye Institute, Hyderabad, India.

Intermittent exotropia (X(T)) is one of the most common form of strabismus with surgery being the mainstay of treatment. The main goal of surgery is to preserve binocular vision and stereopsis and to prevent its further loss. The decision to operate is mainly based on four aspects: increasing angle of exodeviation, deteriorating control of X(T), decrease in stereopsis for near or distance and quality of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440598PMC

Prevalence and causes of childhood blindness in Huidong County, South China, primary ascertained by the key informants.

BMJ Open Ophthalmol 2019 27;4(1):e000240. Epub 2019 Feb 27.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou City, China.

Purpose: The aim of this study is to ascertain the prevalence and causes of childhood blindness and severe visual impairment (BL/SVI) in Huidong, South China.

Methods: This cross-sectional study was conducted in early 2017 in areas of 139 816 children at the age of 0-15 as the study subjects. We used the trained key informants (KIs) to do preliminary visual test in the communities and refer those children suspected with blindness or unable to count fingers with both eyes at 5 m to hospital for further examination by paediatric ophthalmologist for causes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440593PMC
February 2019

New macular findings in individuals with biallelic KLHL7 gene mutation.

BMJ Open Ophthalmol 2019 16;4(1):e000234. Epub 2019 Feb 16.

Department of Paediatric Ophthalmology, Bristol Eye Hospital, Bristol, UK.

Objective: The ubiquitin-proteasome system pathway has been recognised as a crucial cellular mechanism for the proper function of photoreceptor cells. In particular, ubiquitin ligases (E3s) recognise and ubiquitinate specific proteins for degradation. The KLHL7 protein (a BTB-Kelch protein) has been found to play an important role in this process. Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2018-000234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440596PMC
February 2019
1 Read

Comparison of refractive predictability and endothelial cell loss in femtosecond laser-assisted cataract surgery and conventional phaco surgery: prospective randomised trial with 6 months of follow-up.

BMJ Open Ophthalmol 2019 1;4(1):e000233. Epub 2019 Mar 1.

Department of Ophthalmology, Rigshospitalet Glostrup, Glostrup, Denmark.

Objective: Femtosecond laser-assisted cataract surgery (FLACS) decreases the use of energy and provides a more precise capsulorhexis compared with conventional phaco surgery (CPS). The purpose of this study was to examine if the lower energy use in FLACS caused less endothelial cell loss compared with CPS and if there was a difference in refractive predictability between CPS and FLACS.

Methods And Analysis: This was a randomised controlled study of 96 patients with a 6-month follow-up comparing one eye surgery by FLACS and the contralateral eye operated by CPS (divide and conquer technique). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440690PMC

Bandage contact lens and topical steroids are risk factors for the development of microbial keratitis after epithelium-off CXL.

BMJ Open Ophthalmol 2019 16;4(1):e000231. Epub 2019 Feb 16.

St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.

Objective: To investigate the role of bandage contact lenses (BCL) and topical steroids as risk factors for the development of microbial keratitis after epithelium-off corneal collagen cross-linking (CXL).

Methods And Analysis: Patients undergoing CXL between February 2011 and July 2017 were included. Patients were divided into two groups: those who were treated postoperatively with a BCL, topical antimicrobial and steroids (group 1) and those who received only a topical antimicrobial until healing of the epithelial defect before introduction of topical steroids (group 2). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440609PMC
February 2019

Dispersive viscosurgical devices demonstrate greater efficacy in protecting corneal endothelium in vitro.

BMJ Open Ophthalmol 2019 16;4(1):e000227. Epub 2019 Feb 16.

The David J Apple International Laboratory for Ocular Pathology, Heidelberg University Eye Clinic, Heidelberg, Germany.

Objective: During phacoemulsification, the corneal endothelium is protected by an ophthalmic viscosurgical device (OVD). In this in vitro study, we assessed six different OVDs for their effectiveness in protecting the corneal endothelium.

Methods And Analysis: Phacoemulsification was performed in cadaver eyes of young pigs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440605PMC
February 2019
1 Read

Norrie disease gene polymorphism in Indonesian infants with retinopathy of prematurity.

BMJ Open Ophthalmol 2019 27;4(1):e000211. Epub 2019 Feb 27.

Pediatric, Universitair Medisch Centrum Groningen, Groningen, The Netherlands.

Objective: Retinopathy of prematurity (ROP) is a major cause of blindness in newborn infants, which also occurs in low-income and middle-income countries. Why ROP progresses in some infants while it regresses in others is still presently unknown. Studies suggest that genetic factors might be involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440590PMC
February 2019

Estimating the magnitude of diabetes mellitus and diabetic retinopathy in an older age urban population in Pune, western India.

BMJ Open Ophthalmol 2019 28;4(1):e000201. Epub 2019 Feb 28.

Department of Community Ophthalmology, PBMA's H. V. Desai Eye Hospital, Pune, Maharashtra, India.

Objective: To estimate magnitude of diabetes mellitus (DM) and diabetic retinopathy (DR) in a high risk population in Pune, western India.

Methods: DR module in rapid assessment of avoidable blindness (RAAB) survey methodology was used. Sample size of 3527 was calculated based on estimates from previous studies in India. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440599PMC
February 2019
1 Read

Inverted papilloma of the conjunctiva.

BMJ Open Ophthalmol 2019 28;4(1):e000193. Epub 2019 Feb 28.

Department of Pathology, Section for Eye Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Objective: The purpose of the present study is to describe the clinical and histopathological features of conjunctival inverted papilloma, to analyse for the presence of human papillomavirus (HPV), and to determine if HPV infection is associated with this type of tumour and its inverted growth pattern.

Methods And Analysis: Cases of conjunctival inverted papillomas were retrieved from the archives of the Department of Pathology, Rigshospitalet, Denmark. Patient records and pathology reports were reviewed. Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2018-000193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440594PMC
February 2019
1 Read

Systemic pharmacokinetic/pharmacodynamic analysis of intravitreal aflibercept injection in patients with retinal diseases.

BMJ Open Ophthalmol 2019 20;4(1):e000185. Epub 2019 Mar 20.

Bayer Pharma, Berlin, Germany.

Objective: Explore relationships between systemic exposure to intravitreal aflibercept injection (IAI) and systemic pharmacodynamic effects via post hoc analyses of clinical trials of IAI for neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME).

Methods And Analysis: Adults from VGFT-OD-0702.PK (n=6), VGFT-OD-0512 (n= 5), VIEW 2 (n=1204) and VIVID-DME (n=404) studies were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440611PMC

Impact of automated OCT in a high-volume eye urgent care setting.

BMJ Open Ophthalmol 2019 20;4(1):e000187. Epub 2019 Jan 20.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mt. Sinai, New York City, New York, USA.

Background/aims: Optical coherence tomography (OCT) has become standard of care in the diagnosis and management of a myriad of retinal and optic nerve pathology. Access to diagnostic equipment and skilled imaging personnel in the after-hours setting is often limited. We examined the utility and diagnostic indications for automated OCT in a high-volume after-hours clinic within an eye institute. Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2018-000187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340595PMC
January 2019
13 Reads

Role of corneal biomechanical properties in predicting of speed of myopic progression in children wearing orthokeratology lenses or single-vision spectacles.

BMJ Open Ophthalmol 2018 27;3(1):e000204. Epub 2018 Dec 27.

School of Optometry, The Hong Kong Polytechnic University, Hong Kong, Hong Kong.

Objective: To determine the characteristics of children who were likely to progress rapidly and gain the greatest benefit from orthokeratology (ortho-k) treatment.

Methods And Analysis: The files of 113 children who participated in two myopia control studies and wore either ortho-k lenses (n=62) or single-vision spectacles (SVS) (n=51) were reviewed. Baseline cycloplegic subjective refraction, central corneal thickness, axial length, keratometry, intraocular pressure, corneal biomechanical properties and 24-month axial length data were retrieved and analysed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326267PMC
December 2018

Supraciliary microstent implantation for open-angle glaucoma: multicentre 3-year outcomes.

BMJ Open Ophthalmol 2018 22;3(1):e000183. Epub 2018 Dec 22.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, USA.

Objective: To describe the safety and effectiveness of CyPass supraciliary microstent implantation alone in eyes with open-angle glaucoma (OAG) followed up for up to 3 years.

Methods And Analysis: This registry study included subjects with primary or secondary OAG who underwent CyPass Micro-Stent implantation alone at 12 sites in four European countries to reduce intraocular pressure (IOP) and/or use of IOP-lowering medications. The primary safety outcome was the incidence of adverse events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326317PMC
December 2018
1 Read

Exploring the precision of femtosecond laser-assisted descemetorhexis in Descemet membrane endothelial keratoplasty.

BMJ Open Ophthalmol 2018 27;3(1):e000148. Epub 2018 Dec 27.

Department of Ophthalmology, Charité-Medical University Berlin, Berlin, Germany.

Objective: Descemet membrane endothelial keratoplasty (DMEK) remains a challenging technique. We compare the precision of femtosecond laser-assisted DMEK to manual DMEK.

Methods And Analysis: A manual descemetorhexis (DR) of 8 mm diameter was compared with a femtosecond laser-assisted DR of the same diameter (femto-DR) in 22 pseudophakic patients requiring DMEK. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326344PMC
December 2018

Opacification of hydrophilic intraocular lenses associated with vitrectomy and injection of intraocular gas.

BMJ Open Ophthalmol 2018 15;3(1):e000157. Epub 2018 Dec 15.

David J Apple International Laboratory for Ocular Pathology, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.

Objective: To report 11 cases of intraocular lens (IOL) opacification after pars plana vitrectomy (PPV) involving intravitreal gas injection.

Methods And Analysis: Eleven cases of hydrophilic IOLs that opacified following PPV with intravitreal gas injection are described. Eight IOLs were explanted and analysed by light microscopy and scanning electron microscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307569PMC
December 2018
2 Reads

360-degree suture trabeculotomy ab interno with phacoemulsification in open-angle glaucoma and coexisting cataract: a pilot study.

BMJ Open Ophthalmol 2018 25;3(1):e000159. Epub 2018 Oct 25.

Mizoguchi Eye Clinic, Nagasaki, Japan.

Objective: We performed a pilot trial to evaluate the 24-month safety and efficacy of 360-degree suture trabeculotomy ab interno with phacoemulsification used to treat mild to moderate open-angle glaucoma coexisting with cataract.

Methods And Analysis: We randomly assigned 18 eyes with open-angle glaucoma and coexisting cataract to undergo 360-degree suture trabeculotomy ab interno with phacoemulsification (combined) or phacoemulsification alone (control) (1:1 ratio) and followed up patients for 24 months. Main outcome measures were mean postoperative intraocular pressure (IOP) and success probabilities based on Kaplan-Meier life table analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267453PMC
October 2018

Blindness and eye disease in a Tibetan region of China: findings from a Rapid Assessment of Avoidable Blindness survey.

BMJ Open Ophthalmol 2018 17;3(1):e000209. Epub 2018 Nov 17.

British Columbia Center for Epidemiology & International Ophthalmology and Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada.

Introduction: The only population-based survey of blindness and visual impairment of a Tibetan population was conducted in the Tibet Autonomous Region in 1999.

Methods And Analysis: The Rapid Assessment of Avoidable Blindness methodology was used to conduct a survey of Kandze Tibetan Autonomous Prefecture, Sichuan Province of China in the Fall 2017. Using the 2010 census, 100 clusters of 50 participants aged 50 years or older were randomly sampled using probability proportionate to size. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257377PMC
November 2018
5 Reads

Ophthalmic phenotype of TCIRG1 gene mutations in Chinese infantile malignant osteopetrosis.

BMJ Open Ophthalmol 2018 17;3(1):e000180. Epub 2018 Nov 17.

Department of Ophthalmology, Beijing Children's Hospital, National Center for Children's Health, National Key Discipline of Pediatrics, Capital Medical University, Beijing, China.

Objective: To evaluate the ophthalmic phenotypes associated with T-cell immune regulator 1 (TCIRG1) mutations in Chinese patients with infantile malignant osteopetrosis (IMO).

Methods And Analysis: 27 Chinese TCIRG1-related osteoporosis infants were enrolled using direct DNA sequencing of PCR-amplified exons. 12 cases had frameshift mutation (the frameshift mutation group, group F), and 15 cases had point mutation (the point mutation group, group P). Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2018-000180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257380PMC
November 2018
17 Reads

Intraocular lens dislocation: a novel in-situ scleral refixation technique using a 25 Gauge trocar in the anterior chamber.

BMJ Open Ophthalmol 2018 23;3(1):e000174. Epub 2018 Nov 23.

Dipartimento Neuromuscoloscheletrico e Organi di Sensi, Università degli Study di Firenze, Florence, Italy.

Objective: Intraocular lens (IOL) repositioning using a closed-eye approach could be carried out in some selected cases. Our study focuses on the efficacy and safety of a IOL closed-eye repositioning technique using scleral suture, which is performed using a trocar as an intrastromal limbal guide.

Methods And Analysis: Thirty-one eyes of 31 patients with late IOL dislocation operated on between January 2015 and May 2017 were included in this retrospective non-comparative consecutive case series study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257374PMC
November 2018
8 Reads

Assessing photoreceptor structure in patients with traumatic head injury.

BMJ Open Ophthalmol 2018 24;3(1):e000104. Epub 2018 Nov 24.

Department of Ophthalmology and Visual Sciences, University of WI - Madison, Madison, Wisconsin, USA.

Objective: Previous work using adaptive optics scanning light ophthalmoscopy (AOSLO) imaging has shown photoreceptor disruption to be a common finding in head and ocular trauma patients. Here an expanded trauma population was examined using a novel imaging technique, split-detector AOSLO, to assess remnant cone structure in areas with significant disruption on confocal AOSLO imaging and to follow photoreceptor changes longitudinally.

Methods And Analysis: Eight eyes from seven subjects with head and/or ocular trauma underwent imaging with spectral domain optical coherence tomography, confocal AOSLO and split-detector AOSLO to assess foveal and parafoveal photoreceptor structure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257382PMC
November 2018
1 Read

Loss of horizontal macular ganglion cell complex asymmetry: an optical coherence tomography indicator of chiasmal compression.

BMJ Open Ophthalmol 2018 25;3(1):e000195. Epub 2018 Oct 25.

Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway.

Objective: To estimate the macular ganglion cell complex (GCC) asymmetry in patients with suprasellar tumours, to compare its diagnostic performance to the nasal GCC thickness and visual field (VF) and to investigate how the parameters correlate with magnetic resonance imaging (MRI) findings.

Methods And Analysis: Cross-sectional study of patients with suprasellar tumours affecting the optic chiasm. Macular optical coherence tomography (OCT) scans were evaluated for nasal GCC sector thinning and loss of normal GCC asymmetry between corresponding nasal-temporal sectors. Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2018-000195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243475PMC
October 2018
14 Reads

Increased sensitivity of microbiological testing of cornea organ culture medium by additional resin treatment.

BMJ Open Ophthalmol 2018 10;3(1):e000173. Epub 2018 Nov 10.

Institute for Transfusion Medicine, University Tissue Bank, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objective: This validation study investigates the treatment of cornea organ culture medium (Modified Eagle Medium, Biochrom GmbH, Berlin, Germany) with RESEP, a new medical device for antibiotics removal, before microbiological testing with BACTEC blood culture bottles.

Methods And Analysis: 10-100 colony forming units of and were inoculated in 9mL of cornea organ culture medium. In group A, the medium was withdrawn with RESEP and treated for 20 min at room temperature, and then inoculated in BACTEC Plus Aerobic/F/Anaerobic/F blood culture bottles. Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2018-000173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243474PMC
November 2018
15 Reads

Prospective pilot study comparing deep sclerectomy outcomes with a long-term and intense corticosteroid treatment versus a standard one.

BMJ Open Ophthalmol 2018 31;3(1):e000165. Epub 2018 Oct 31.

Glaucoma and Neuro-Ophthalmology Department, FISABIO Oftalmologia, Valencia, Spain.

Objective: To compare prospectively intraocular pressure (IOP) results after deep sclerectomy (DS) using a topical short-term corticosteroid treatment (STCT, 1  month) versus a topical long-term and intense corticosteroid treatment (LTCT, 6 months) in a two2  year-follow-up.

Methods: Patients with medically uncontrolled open angle glaucoma were prospectively recruited and underwent a DS.

Results: We operated 45 eyes of 45 patients, 22 in STCT group and 23 in LTCT group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243469PMC
October 2018
4 Reads

Sex, gender and blindness: a new framework for equity.

BMJ Open Ophthalmol 2018 1;3(1):e000135. Epub 2018 Sep 1.

Moorfields Eye Hospital, London, UK.

Four-fifths of all blind or vision impaired people live in middle-income and low-income countries with the African region and parts of Asia and the Middle East bearing the heaviest burden. At the same time, we know that around two thirds of all blind people in the world are female. Hence, the poorest (and usually the oldest) women are most likely to have their lives limited by visual impairment. Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2017-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2017-000135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146307PMC
September 2018
2 Reads

Twenty years of limbal epithelial therapy: an update on managing limbal stem cell deficiency.

BMJ Open Ophthalmol 2018 10;3(1):e000164. Epub 2018 Aug 10.

Department of Cornea and External Diseases, Moorfields Eye Hospital-NHS Foundation Trust, London, UK.

Limbal stem cell damage after chemical injury, autoimmune disorders or iatrogenic trauma leads to corneal conjunctivalisation with new vessel formation, epithelium instability and visual loss. Limbal stem cell transplantation includes reconstructive surgical procedures to restore a corneal epithelium. The recognised options are: conjunctival limbal autograft, in which stem cells are taken from the patient's healthy eye; conjunctival limbal allograft, in which stem cells are taken from a living, related or dead donor and the keratolimbal allograft. Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2018-000164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093197PMC
August 2018
19 Reads

Acupuncture and herbal formulation compared with artificial tears alone: evaluation of dry eye symptoms and associated tests in randomised clinical trial.

BMJ Open Ophthalmol 2018 18;3(1):e000150. Epub 2018 Jun 18.

Singapore Chung Hwa Medical Institution, Singapore.

Objective: Dry eye is a common disease with great health burden and no satisfactory treatment. Traditional Chinese medicine, an increasingly popular form of complementary medicine, has been used to treat dry eye but studies have been inconclusive. To address this issue, we conducted a randomised investigator-masked study which included the robust assessment of disease mechanisms. Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2018-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2018-000150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093252PMC
June 2018
2 Reads

Visual performance in a flight simulator: multifocal intraocular lenses in pilots.

Authors:
Lee Lenton

BMJ Open Ophthalmol 2018 4;3(1):e000139. Epub 2018 Jun 4.

Vision Eye Institute Clinic, Brisbane, Queensland, Australia.

Objective: To compare the performance of adults with multifocal intraocular lenses (MIOLs) in a realistic flight simulator with age-matched adults with monofocal intraocular lenses (IOLs).

Methods And Analysis: Twenty-five adults ≥60 years with either bilateral MIOL or bilateral IOL implantation were enrolled. Visual function tests included visual acuity and contrast sensitivity under photopic and mesopic conditions, defocus curves and low luminance contrast sensitivity tests in the presence and absence of glare (Mesotest II), as well as halo size measurement using an app-based halometer (Aston halometer). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093254PMC
June 2018
14 Reads

The Efficacy of Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors for the treatment of chronic diabetic macular oedema in vitrectomised eyes: a retrospective study.

BMJ Open Ophthalmol 2018 23;3(1):e000130. Epub 2018 Jul 23.

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Objective: To investigate the change of chronic diabetic macular oedema (DMO) in vitrectomised eyes when the administration of sodium-glucose cotransporter 2 (SGLT2) inhibitors is initiated as a systemic medical treatment.

Methods And Analysis: This study involved 10 eyes of five patients with chronic DMO lasting more than 6 months who had previously undergone vitrectomy and whose systemic medical treatments were newly changed to SGLT2 inhibitors. In this study, chronic DMO was defined as persistent diffuse macular oedema despite ophthalmic treatment in patients with diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093251PMC
July 2018
1 Read

Italian real-life experience on the use of ocriplasmin.

BMJ Open Ophthalmol 2018 10;3(1):e000110. Epub 2018 Aug 10.

Department of Surgical and Translational Medicine, Ophthalmology, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

Objective: To evaluate the success of an intravitreal injection of ocriplasmin to release symptomatic vitreomacular traction (VMT) and close a full-thickness macular hole.

Methods And Analysis: An observational retrospective multicentre study conducted in Italy. Patients with symptomatic distortion and loss of vision secondary to VMT were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093221PMC
August 2018
8 Reads

Safety and efficacy of 4-terpineol against microorganisms associated with blepharitis and common ocular diseases.

BMJ Open Ophthalmol 2018 4;3(1):e000094. Epub 2018 Jun 4.

Tissue Tech, Inc. R&D Dept. and Ocular Surface Center, Miami, Florida, USA.

Objective: Microbial infection has been reported to cause blepharitis, conjunctivitis and keratitis. We evaluated the safety and efficacy of a foam formulation of 2% 4-terpineol (T4O) against common ocular microorganisms.

Material And Methods: The antimicrobial effect of a 2% T4O formulation was evaluated by the United States Pharmacopeia 51 (USP <51>) antimicrobial effectiveness test for 14 and 28 days, as well as by a Time Kill Study (ASTM E2315) with a 60 s exposure time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093255PMC
June 2018
2 Reads

Correction: .

Authors:

BMJ Open Ophthalmol 2018 7;3(1). Epub 2018 Jul 7.

[This corrects the article DOI: 10.1136/bmjophth-2016-000032.]. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2016-000032corr1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093253PMC

Digital eye strain: prevalence, measurement and amelioration.

BMJ Open Ophthalmol 2018 16;3(1):e000146. Epub 2018 Apr 16.

School of Life and Health Sciences, Aston University, Birmingham, UK.

Digital device usage has increased substantially in recent years across all age groups, so that extensive daily use for both social and professional purposes is now normal. Digital eye strain (DES), also known as computer vision syndrome, encompasses a range of ocular and visual symptoms, and estimates suggest its prevalence may be 50% or more among computer users. Symptoms fall into two main categories: those linked to accommodative or binocular vision stress, and external symptoms linked to dry eye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2018-000146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020759PMC

LncRNAs in genetic basis of glaucoma.

BMJ Open Ophthalmol 2018 29;3(1):e000131. Epub 2018 Mar 29.

Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Glaucoma is an umbrella term used to designate a heterogeneous group of ocular disorders characterised by progressive excavation of the optic disc, optic atrophy and gradual loss of the visual field caused by the slow death of retinal ganglion cells and their axons. Glaucoma can potentially lead to blindness if left untreated. It usually starts from the periphery and progresses gradually toward the centre of the visual field. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020790PMC
March 2018
19 Reads

Epithelial ingrowth following laser in situ keratomileusis (LASIK): prevalence, risk factors, management and visual outcomes.

BMJ Open Ophthalmol 2018 29;3(1):e000133. Epub 2018 Mar 29.

Sunderland Eye Infirmary, Sunderland, UK.

The number of laser in situ keratomileusis (LASIK) procedures is continuing to rise. Since its first application for correcting simple refractive errors over 25 years ago, the role of LASIK has extended to treat other conditions, including postkeratoplasty astigmatism/ametropia, postcataract surgery refractive error and presbyopia, among others. The long-term effectiveness, predictability and safety have been well established by many large studies. Read More

View Article

Download full-text PDF

Source
http://bmjophth.bmj.com/lookup/doi/10.1136/bmjophth-2017-000
Publisher Site
http://dx.doi.org/10.1136/bmjophth-2017-000133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895975PMC
March 2018
6 Reads

Acceptability and use of glaucoma virtual clinics in the UK: a national survey of clinical leads.

BMJ Open Ophthalmol 2018 16;3(1):e000127. Epub 2018 Feb 16.

Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester, UK.

Objective: The purpose of this paper is to describe the findings of a national survey that aimed to estimate the proportion of Hospital Eye Service (HES) units using glaucoma virtual clinics, to determine how these services differ and to gauge clinicians' views and opinions on the safety and acceptability of this model of care compared with usual care.

Methods And Analysis: This 12-question survey was disseminated nationally to 92 clinical lead consultant ophthalmologists using SurveyMonkey.

Results: The response rate was 45. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895974PMC
February 2018
1 Read

Clinical safety of a minor eye conditions scheme in England delivered by community optometrists.

BMJ Open Ophthalmol 2018 20;3(1):e000125. Epub 2018 Feb 20.

Division of Optometry and Visual Science, Centre for Applied Vision Research, City University of London, London, UK.

Objective: The aim of this study was to monitor the activity and evaluate the clinical safety of a minor eye conditions scheme (MECS) conducted by accredited community optometrists in Lambeth and Lewisham, London.

Methods And Analysis: Optometrists underwent an accredited training programme, including attendance at hospital eye services (HES) clinics. Patients who satisfied certain inclusion criteria were referred to accredited MECS optometrists by their general practitioners (GPs) or could self-refer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895973PMC
February 2018
1 Read

Ready-made and custom-made eyeglasses in India: a cost-effectiveness analysis of a randomised controlled trial.

BMJ Open Ophthalmol 2018 9;3(1):e000123. Epub 2018 Feb 9.

The George Institute for Global Health, University of NSW Sydney, Newtown, New South Wales, Australia.

Objective: Ready-made spectacles have been suggested as a less resource-intensive treatment for the millions of people living with uncorrected refractive error (URE) in low-income environments. In spite of this interest, there have been no published economic evaluations examining the cost-effectiveness of ready-made spectacles. This study aims to determine the relative cost-effectiveness of offering ready-made spectacles (RMS) relative to no intervention as well as the relative cost-effectiveness of custom-made spectacles (CS) relative to RMS to treat URE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895972PMC
February 2018

Relationship between electronically measured medication adherence and vision-related quality of life in a cohort of patients with open-angle glaucoma.

BMJ Open Ophthalmol 2018 19;3(1):e000114. Epub 2018 Feb 19.

Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.

Objective: To investigate whether electronically measured medication adherence is associated with vision-related quality of life (VRQoL) in patients with open-angle glaucoma.

Methods And Analysis: This is a 3-year prospective cohort study of 79 subjects with open-angle glaucoma at a Veterans Affairs medical centre. Participants returned a medication event monitoring system (MEMS) for their glaucoma eye-drops and had at least two visits with glaucoma during the study period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895971PMC
February 2018
8 Reads

Expert practice patterns and opinions on corneal cross-linking for infectious keratitis.

BMJ Open Ophthalmol 2018 16;3(1):e000112. Epub 2018 Mar 16.

Department of Ophthalmology, University of California, San Francisco, California, USA.

Objective: To assess the current opinion and practice patterns from cornea experts regarding the benefit of corneal cross-linking (CXL) for infectious keratitis (IK).

Methods And Analysis: An international survey was distributed to corneal specialists via an internet survey. The survey data collected were analysed with descriptive statistics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895970PMC
March 2018
1 Read

Efficacy of additional topical betamethasone in persistent cystoid macular oedema after carbonic anhydrase inhibitor treatments in retinitis pigmentosa.

BMJ Open Ophthalmol 2018 28;3(1):e000107. Epub 2018 Jan 28.

Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.

Objective: We investigated the efficacy of additional topical betamethasone in persistent cystoid macular oedema (CMO) after carbonic anhydrase inhibitors (CAIs) therapy.

Methods And Analysis: This retrospective cohort study included 16 eyes of 10 patients with retinitis pigmentosa (RP). All patients were previously administered CAI for at least 3 months to treat CMO secondary to RP and lacking an effective reduction (≥11%) of central foveal thickness (CFT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895969PMC
January 2018
7 Reads

Visual pathway function and structure in Wolfram syndrome: patient age, variation and progression.

BMJ Open Ophthalmol 2018 18;3(1):e000081. Epub 2018 Jan 18.

Department of Ophthalmology, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri, USA.

Background/aims: To report alterations in visual acuity and visual pathway structure over an interval of 1-3 years in a cohort of children, adolescents and young adults who have Wolfram syndrome (WFS) and to describe the range of disease severity evident in patients with WFS whose ages differed by as much as 20 years at first examination.

Methods: Annual, prospective ophthalmological examinations were performed in conjunction with retinal nerve fibre layer (RNFL) analysis. Diffusion tensor MRI-derived fractional anisotropy was used to assess the microstructural integrity of the optic radiations (OR FA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895968PMC
January 2018
1 Read

Monocular and binocular visual impairment in the UK Biobank study: prevalence, associations and diagnoses.

BMJ Open Ophthalmol 2018 31;3(1):e000076. Epub 2018 Jan 31.

Academic Unit of Public Health, University of Leeds, Leeds, UK.

Objective: To determine the prevalence of, associations with and diagnoses leading to mild visual impairment or worse (logMAR >0.3) in middle-aged adults in the UK Biobank study.

Methods And Analysis: Prevalence estimates for monocular and binocular visual impairment were determined for the UK Biobank participants with fundus photographs and spectral domain optical coherence tomography images. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895967PMC
January 2018
3 Reads

Evaluation of effect of bevacizumab on central subfield macular thickness in the injected and contralateral (untreated) eye of patients with bilateral diabetic macular oedema.

BMJ Open Ophthalmol 2017 10;2(1):e000102. Epub 2017 Dec 10.

Department of Ophthalmology, B P Koirala Lions Centre for Ophthalmic Studies, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Purpose: Antivascular endothelial growth factor (anti-VEGFs)-bevacizumab is routinely utilised for the treatment of diabetic macular oedema (DME). We plan to evaluate the impact of bevacizumab on the central subfield macular thickness (CSMT) of the treated and untreated eye.

Methods: A sequential group of patients with bilateral DME who were treated with unilateral bevacizumab injection were assessed preinjection and postinjection by Spectral Domain-Optical Coherence Tomography (SD-OCT) by CSMT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895978PMC
December 2017
9 Reads

Correction: Therapeutic potential of omega-3 fatty acids supplementation in a mouse model of dry macular degeneration.

Authors:

BMJ Open Ophthalmol 2017 14;2(1):e000056corr1. Epub 2017 Nov 14.

[This corrects the article DOI: 10.1136/bmjophth-2016-000056.][This corrects the article DOI: 10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2016-000056corr1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751863PMC
November 2017

Neither non-toxigenic nor commensal activates NLRP3 inflammasomes in human conjunctival goblet cells.

BMJ Open Ophthalmol 2017 16;2(1):e000101. Epub 2017 Nov 16.

Schepens Eye Research Institute/Massachusetts Eye and Ear, Boston, Massachusetts, USA.

Purpose: The conjunctiva is a wet mucosal surface surrounding the cornea that is continuously exposed to pathogens. Nevertheless, persistent inflammation is not observed. We examined if the NOD-like receptor pyrin domain 3 (NLRP3) inflammasome functions as a sensor that distinguishes commensal and non-pathogenic bacteria from pathogenic bacteria in human conjunctival goblet cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751869PMC
November 2017
2 Reads

Development and pilot-testing of patient decision aid for use among Chinese patients with primary open-angle glaucoma.

BMJ Open Ophthalmol 2017 14;2(1):e000100. Epub 2017 Dec 14.

Department of Ophthalmology, The University of Hong Kong, Hong Kong, China.

Background: A patient decision aid (PDA) is a tool for shared decision making (SDM), which emphasises patient empowerment. It is useful in chronic diseases and when there are multiple, no best single treatment option. Although SDM is prevalent in Western countries, its use is limited in Chinese societies, where the adoption of a paternalistic approach is strong. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751868PMC
December 2017
1 Read

Results of a community-based screening programme for diabetic retinopathy and childhood blindness in district Hyderabad, Pakistan.

BMJ Open Ophthalmol 2017 15;2(1):e000099. Epub 2017 Dec 15.

Department of Ophthalmology, Sindh Institute of Ophthalmology and Visual Sciences, Hyderabad, Sindh, Pakistan.

Purpose: To present the results of a community-based screening programme for diabetes, diabetic retinopathy (DR) and childhood blindness (CB) in District Hyderabad, Pakistan.

Methods: Prospective cross-sectional data collection from January 2014 to December 2015 of screening for diabetes, DR and CB in Hyderabad District. Female health workers were trained to identify high-risk (potential) patients for diabetes and childhood eye disorders to undertake preliminary screening and refer patients to basic health units. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751866PMC
December 2017
3 Reads

Transcorneal electrical stimulation for the treatment of retinitis pigmentosa: results from the TESOLAUK trial.

BMJ Open Ophthalmol 2017 14;2(1):e000096. Epub 2017 Dec 14.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Objective: To explore the impact of weekly transcorneal electrical stimulation (TES) over a 6-month period as a treatment for retinitis pigmentosa (RP).

Methods And Analysis: A prospective open-label observational trial was carried out assessing weekly TES in participants with RP for a period of 6 months followed by observation for a further 6 months. Clinical examination and investigations were carried out at 3 monthly intervals for a total of 12 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751865PMC
December 2017
2 Reads

Method for sterility testing of corneal storage and transport media after removal of interfering antimicrobials: prospective validation study in compliance with the European Pharmacopoeia.

BMJ Open Ophthalmol 2017 15;2(1):e000093. Epub 2017 Nov 15.

Research and Development, Alchilife S.r.l., Ponte San Nicolò (PD), Italy.

Objective: This study aimed at validating the method for sterility testing of the corneal culture medium, TISSUE-C, and the transport/deswelling medium, CARRY-C, according to the method suitability test, as defined by the European Pharmacopoeia (EP), using RESEP, which is a new medical device for removal of antimicrobial agents and an automated culture system.

Methods And Analysis: The six EP reference strains were inoculated in TISSUE-C and CARRY-C. Half of the samples were treated with RESEP (RESEP+ group) prior to the sterility testing, whereas the remaining samples were untreated (RESEP- group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjophth-2017-000093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751867PMC
November 2017
6 Reads