258 results match your criteria BMJ open gastroenterology[Journal]


Risk of primary gastrointestinal cancers following incident non-metastatic breast cancer: a Danish population-based cohort study.

BMJ Open Gastroenterol 2020 Jun;7(1)

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Objective: We examined the risk of primary gastrointestinal cancers in women with breast cancer and compared this risk with that of the general population.

Design: Using population-based Danish registries, we conducted a cohort study of women with incident non-metastatic breast cancer (1990-2017). We computed cumulative cancer incidences and standardised incidence ratios (SIRs). Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328750PMC

Colon capsule endoscopy in colorectal cancer screening: a randomised controlled trial.

BMJ Open Gastroenterol 2020 Jun;7(1)

Department of Surgery, Odense University Hospital, Svendborg, Denmark.

Introduction: The use of capsule endoscopy has become an approved method in small bowel diagnostics, but the same level of integration is not seen in large bowel diagnostics. We will use colon capsule endoscopy (CCE) as a filter test in colorectal cancer (CRC) screening between the faecal immunochemical test (FIT) and colonoscopy. We aim to investigate the clinical performance, population acceptability, and economic implications of the procedure in a large-scale clinical trial. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326244PMC

Visceral Adiposity Index is a predictor of incident colorectal cancer: a population-based longitudinal study.

BMJ Open Gastroenterol 2020 Jun;7(1)

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Objective: The Visceral Adiposity Index (VAI) is a marker of visceral fat accumulation and dysfunction. We aimed to investigate the association between VAI and incident colorectal cancer (CRC).

Design: In this historical cohort study of 27 921 (16 434 men and 11 487 women) participants, we divided the participants into tertiles according to VAI. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322272PMC

Intestinal stem cells promote crypt fission during postnatal growth of the small intestine.

BMJ Open Gastroenterol 2020 Jun;7(1)

Surgery, The University of Adelaide - North Terrace Campus, Adelaide, South Australia, Australia.

Objective: Wnt-β-catenin signalling is essential for intestinal stem cells. Our aim was to investigate the relationship between intestinal stem cells and crypt fission which peaks during infancy.

Design: Duodenal biopsies were obtained during endoscopy to assess the severity of reflux oesophagitis of 15 infants, children and teenagers, which would not affect the duodenum. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319781PMC

Estimating deaths from foodborne disease in the UK for 11 key pathogens.

BMJ Open Gastroenterol 2020 Jun;7(1)

Information Team, West Suffolk NHS Foundation Trust, Bury St Edmunds, UK.

Objective: To estimate the number of deaths from foodborne disease in the UK from 11 key pathogens.

Design: Four different models were developed using data from a range of sources. These included enhanced surveillance, outbreaks, death certificates and hospital episode statistics data. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319714PMC

Pneumatosis intestinalis in COVID-19.

BMJ Open Gastroenterol 2020 06;7(1)

Medicina Interna, Azienda USL Toscana centro, Ospedale Santa Maria Annunziata, Firenze, Italy.

Introduction: COVID-19 is a respiratory illness due to novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), described in December 2019 in Wuhan (China) and rapidly evolved into a pandemic. Gastrointestinal (GI) tract can also be involved.

Case Presentation: A 44-year-old man was hospitalised for COVID-19-associated pneumonia. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287500PMC

Clinical codes combined with procedure codes increase diagnostic accuracy of Crohn's disease in a US Military health record.

BMJ Open Gastroenterol 2020 26;7(1):e000378. Epub 2020 Feb 26.

Crohn's and Colitis Center of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Background And Aims: Previous examinations of International Classification of Disease, Ninth Revision, Clinical Modification (ICD-9-CM) codes to predict accuracy of diagnosis in inflammatory bowel disease have had limited chart review to confirm diagnosis. We aimed to evaluate using the ICD-9-CM for identifying Crohn's disease (CD) in a large electronic health record (EHR) database.

Methods: This is a retrospective case-control study with a 3:1 allocation of EHRs of active duty service members diagnosed with CD from 1996 to 2012. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254129PMC
February 2020

Gut microbiome composition and risk factors in a large cross-sectional IBS cohort.

BMJ Open Gastroenterol 2020 6;7(1):e000345. Epub 2020 Apr 6.

Medical Affairs, uBiome, San Francisco, California, USA.

Objective: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is difficult to diagnose and treat due to its inherent heterogeneity and unclear aetiology. Although there is evidence suggesting the importance of the microbiome in IBS, this association remains poorly defined. In the current study, we aimed to characterise a large cross-sectional cohort of patients with self-reported IBS in terms of microbiome composition, demographics, and risk factors. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254124PMC

Acute appendicitis is associated with appendiceal microbiome changes including elevated levels.

BMJ Open Gastroenterol 2020 Jun;7(1)

Medically Associated Science and Technology (MAST) Program, Cedars-Sinai Medical Center, Los Angeles, California, USA

Objectives: To compare the appendiceal microbiomes and examine the prevalence of species in the appendices of adult subjects with confirmed acute non-perforated appendicitis and controls with healthy appendices.

Design: Archived samples of formalin-fixed paraffin-embedded appendiceal tissues were obtained from 50 consecutive female subjects who underwent appendectomy for acute, non-perforated appendicitis, and 35 consecutive female controls who underwent incidental appendectomy during gynaecological surgery.

Results: 16S rRNA gene sequencing revealed that the relative abundances (RAs) of the major phyla in appendiceal tissues (Firmicutes, Proteobacteria, Bacteroidetes, and Actinobacteria) were similar in both groups. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279619PMC

Panenteric capsule endoscopy versus ileocolonoscopy plus magnetic resonance enterography in Crohn's disease: a multicentre, prospective study.

BMJ Open Gastroenterol 2020 Jun;7(1)

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: Crohn's disease diagnosis and monitoring remains a great clinical challenge and often requires multiple testing modalities. Assessing Crohn's disease activity in the entire gastrointestinal (GI) tract using a panenteric capsule endoscopy (CE) system could be used as an alternative to colonoscopy and cross-sectional imaging. This study assessed the accuracy and safety of panenteric CE in Crohn's disease as compared with ileocolonoscopy (IC) and/or magnetic resonance enterography (MRE). Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282309PMC

Novelty in the gut: a systematic review and meta-analysis of the gastrointestinal manifestations of COVID-19.

BMJ Open Gastroenterol 2020 05;7(1)

Division of Gastroenterology, Syracuse VA Medical Center, Syracuse, New York, USA.

Background: The COVID-19 epidemic has affected over 2.6 million people across 210 countries. Recent studies have shown that patients with COVID-19 experience relevant gastrointestinal (GI) symptoms. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252994PMC

Refinement and validation of the IDIOM score for predicting the risk of gastrointestinal cancer in iron deficiency anaemia.

BMJ Open Gastroenterol 2020 May;7(1)

Department of Gastroenterology, Poole Hospital NHS Foundation Trust, Poole, UK

Objective: To refine and validate a model for predicting the risk of gastrointestinal (GI) cancer in iron deficiency anaemia (IDA) and to develop an app to facilitate use in clinical practice.

Design: Three elements: (1) analysis of a dataset of 2390 cases of IDA to validate the predictive value of age, sex, blood haemoglobin concentration (Hb), mean cell volume (MCV) and iron studies on the probability of underlying GI cancer; (2) a pilot study of the benefit of adding faecal immunochemical testing (FIT) into the model; and (3) development of an app based on the model.

Results: Age, sex and Hb were all strong, independent predictors of the risk of GI cancer, with ORs (95% CI) of 1. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247388PMC

Endoscopic ultrasound (EUS) and the management of pancreatic cancer.

BMJ Open Gastroenterol 2020 May;7(1)

Department of Medicine, Section Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.

Pancreatic cancer is one of the leading causes of cancer-related mortality in western countries. Early diagnosis of pancreatic cancers plays a key role in the management by identification of patients who are surgical candidates. The advancement in the radiological imaging and interventional endoscopy (including endoscopic ultrasound (EUS), endoscopic retrograde cholangiopancreatography and endoscopic enteral stenting techniques) has a significant impact in the diagnostic evaluation, staging and treatment of pancreatic cancer. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232396PMC

Spatial expression of glucagon-like peptide 1 receptor and caveolin-1 in hepatocytes with macrovesicular steatosis in non-alcoholic steatohepatitis.

BMJ Open Gastroenterol 2020 May;7(1)

Department of Clinical Pharmacy, Kitasato University School of Pharmacy, Minato-ku, Tokyo, Japan.

Objective: Non-alcoholic steatohepatitis (NASH) can progress to fibrosis, cirrhosis and end-stage liver disease. Glucagon-like peptide 1 receptor (GLP-1R) mediates β cell function. Its receptor agonists, currently used to treat type 2 diabetes mellitus, might be effective against NASH. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232783PMC

Acute kidney injury after multiphase imaging for lesions detected on hepatocellular carcinoma surveillance in patients with cirrhosis.

BMJ Open Gastroenterol 2020 May;7(1)

Section of Gastroenterology & Hepatology, West Virginia University, Morgantown, West Virginia, USA.

Objective: The risk difference between multiphase multidetector contrast-enhanced CT and MRI for developing acute kidney injury (AKI) has not been previously evaluated in patients with cirrhosis undergoing hepatocellular carcinoma (HCC) surveillance. We aimed to compare the rate of AKI after CT and MRI for evaluation of these lesions.

Design: A retrospective chart review of all patients with cirrhosis who underwent either multiphase multidetector liver protocol CT or MRI for lesions detected on HCC screening was conducted at West Virginia University. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222874PMC

Life-threatening onset of coeliac disease: a case report and literature review.

BMJ Open Gastroenterol 2020 May;7(1)

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy

Background: Coeliac disease (CD) results from an immune-mediated reaction to gluten in genetically predisposed individuals. In rare cases CD may occur with acute features deferring the diagnosis and exposing these patients to possible life-threatening complications. Herein we present the case of a young woman with a coeliac crisis, that is, a sudden clinical onset characterised by severe electrolyte imbalance due to an unknown (previously unrecognised) CD. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223027PMC

Prevalence and sociodemographic determinants of dyspepsia in the general population of Rwanda.

BMJ Open Gastroenterol 2020 May;7(1)

Calvary Mater Newcastle, Waratah, New South Wales, Australia

Introduction: Dyspepsia accounts for a significant burden of worldwide disease, but there is a relative paucity of data from the sub-Saharan African setting. We undertook to describe the burden, risk factors and severity of dyspepsia across Rwanda.

Methods: We performed a population-based clustered cross-sectional survey between November 2015 and January 2016, nationwide in Rwanda, using the Short Form Leeds Dyspepsia Questionnaire to describe the presence and severity of dyspepsia, and the Short Form Nepean Dyspepsia Index to describe the concomitant quality of life effects. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222881PMC

Hepatitis C elimination in the Netherlands (CELINE): study protocol for nationwide retrieval of lost to follow-up patients with chronic hepatitis C.

BMJ Open Gastroenterol 2020 12;7(1):e000396. Epub 2020 Apr 12.

Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, the Netherlands.

Background: The Netherlands has a low hepatitis C virus (HCV) prevalence, estimated at 0.16%. Previous studies have shown that up to 30% of the diagnosed HCV population in the Netherlands has been lost to follow-up (LTFU). Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199651PMC

Antitumour necrosis factor-α agents and development of new-onset cirrhosis or non-alcoholic fatty liver disease: a retrospective cohort.

BMJ Open Gastroenterol 2020 15;7(1):e000349. Epub 2020 Apr 15.

Division of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Objective: Elevated tumour necrosis factor (TNF)-α has been implicated in the progression of liver fibrosis and pathogenesis of non-alcoholic fatty liver disease (NAFLD). We aim to investigate the impact of anti-TNF-α agents on the development of cirrhosis and NAFLD.

Design: This retrospective cohort study used a US claims database between 1 January 2010 and 31 December 2016. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199652PMC

SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice.

BMJ Open Gastroenterol 2020 May;7(1)

Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: In non-alcoholic steatohepatitis (NASH), muscle wasting was an aggravating factor for the progression of hepatic steatosis. This study explores the potential benefits of chronic treatment with resveratrol, a strong activator of SIRT1 on the muscle wasting of NASH mice.

Methods: In vivo and in vitro study, we evaluate the SIRT1-dependent mechanisms and effects of resveratrol administration for 6 weeks with high-fat-methionine and choline deficient diet-induced NASH mice and palmitate-pretreated C2C12 myoblast cells. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228468PMC

Effect of an intensive patient educational programme on the quality of bowel preparation for colonoscopy: a single-blind randomised controlled trial.

BMJ Open Gastroenterol 2020 May;7(1)

Centre for Clinical Trial, Institute for Clinical Research, Shah Alam, Selangor Darul Ehsan, Malaysia.

Objective: Preprocedural bowel preparation is necessary for optimal colonoscopy visualisation. However, it is challenging to achieve high-quality bowel preparation among patients scheduled for colonoscopy. This study aims to evaluate the impact of an intensive patient educational programme on the quality of bowel preparation. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228661PMC

Deep learning in gastric tissue diseases: a systematic review.

BMJ Open Gastroenterol 2020 26;7(1):e000371. Epub 2020 Mar 26.

Laboratório de Genética Humana e Médica - Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.

Background: In recent years, deep learning has gained remarkable attention in medical image analysis due to its capacity to provide results comparable to specialists and, in some cases, surpass them. Despite the emergence of deep learning research on gastric tissues diseases, few intensive reviews are addressing this topic.

Method: We performed a systematic review related to applications of deep learning in gastric tissue disease analysis by digital histology, endoscopy and radiology images. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170401PMC

Effectiveness of phosphatidylcholine as adjunctive therapy in improving liver function tests in patients with non-alcoholic fatty liver disease and metabolic comorbidities: real-life observational study from Russia.

BMJ Open Gastroenterol 2020 26;7(1):e000368. Epub 2020 Mar 26.

Medical Affairs, Sanofi-Aventis SA, Moscow, Russian Federation.

Objective: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal results of liver function tests. Earlier research showed that polyenylphosphatidylcholine (PPC) has hepatoprotective effects and thus can be used for the treatment of NAFLD and the prevention of its progression. Accordingly, the aim of this observational study was to evaluate if PPC administered as adjunctive therapy in routine clinical practice can effectively improve liver function tests of NAFLD in Russian patients with associated metabolic comorbidities. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170405PMC

Risk of colorectal cancer in a population-based study 20 years after diagnosis of ulcerative colitis: results from the IBSEN study.

BMJ Open Gastroenterol 2020 26;7(1):e000361. Epub 2020 Mar 26.

Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.

Objective: The association between ulcerative colitis (UC) and colorectal cancer (CRC) is widely accepted, although attenuated risk has been reported in recent years. Colonoscopic surveillance is recommended with intervals based on established clinical risk factors. Nevertheless, a significant number of patients develop interval cancers, indicating the need of improved individualised assessment. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170403PMC

Rare case of EBV-induced colitis in an immunocompetent individual.

BMJ Open Gastroenterol 2020 25;7(1):e000360. Epub 2020 Mar 25.

Gastroenterology and Hepatology Division, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Epstein-Barr virus (EBV) is a member of the herpes virus family and affects people worldwide. EBV-infected colitis can occur in patients in immunocompromised states. However, EBV-induced colitis in immunocompetent patients is extremely rare. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170404PMC

Changes in metabolic complications in patients with alcoholic fatty liver disease monitored over two decades: NAGALA study.

BMJ Open Gastroenterol 2020 6;7(1):e000359. Epub 2020 Apr 6.

Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Objective: The social conditions are changing in the world, which may contribute to the change in lifestyle, including alcohol consumption and dietary intake; however, changes in metabolic complications in patients with alcoholic fatty liver disease (AFLD) have never been reported. Therefore, here we compare the metabolic complications in current AFLD with those of two decades ago.

Methods: We performed this cross-sectional study in a Japanese health check-up centre. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170409PMC

Comparative quantitative survey of patient experience in Barrett's oesophagus and other gastrointestinal disorders.

BMJ Open Gastroenterol 2020 31;7(1):e000357. Epub 2020 Mar 31.

Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK.

Objective: To assess health-related quality of life in patients with non-dysplastic Barrett's oesophagus (NDBO) and endoscopically treated dysplastic Barrett's oesophagus (DBO).

Design: This quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals. Data were collected from three other cohorts; gastro-oesophageal reflux disease (GORD), colonic polyp surveillance and healthy individuals. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170407PMC

Impact of comorbidities on anti-TNFα response and relapse in patients with inflammatory bowel disease: the VERNE study.

BMJ Open Gastroenterol 2020 26;7(1):e000351. Epub 2020 Mar 26.

Department of Gastroenterology, Hospital Clínico Universitario de Santiago de Compostela, Madrid, Spain.

Objective: To evaluate the impact of comorbidities and extraintestinal manifestations of inflammatory bowel disease on the response of patients with inflammatory bowel disease to antitumour necrosis factor alpha (anti-TNFα) therapy.

Design: Data from 310 patients (194 with Crohn's disease and 116 with ulcerative colitis) treated consecutively with the first anti-TNFα in 24 Spanish hospitals were retrospectively analysed. Univariate and multivariate logistic regression analyses were performed to assess the associations between inflammatory bowel disease comorbidities and extraintestinal manifestations with anti-TNFα treatment outcomes. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170400PMC

Lower gastrointestinal symptoms and symptoms-based triaging systems are poor predictors of clinical significant disease on colonoscopy.

BMJ Open Gastroenterol 2020 31;7(1):e000221. Epub 2020 Mar 31.

Gastroenterology, Tallaght University Hospital, Dublin, Ireland.

Introduction: Lower gastrointestinal symptoms (LGS) are a common cause of referral to the gastroenterology service. International guidelines are available to prioritise referrals. Some studies have reported that symptoms alone are a poor marker of clinically significant disease (CSD) but symptoms remain the main way to prioritise referrals in routine clinical practice. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170406PMC

Outcomes of inflammatory bowel disease in patients with eosinophil-predominant colonic inflammation.

BMJ Open Gastroenterol 2020 16;7(1):e000373. Epub 2020 Feb 16.

Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.

Background: Inflammatory bowel disease (IBD) is characterised by acute intestinal mucosal inflammation with chronic inflammatory features. Various degrees of mucosal eosinophilia are present along with the typical acute (neutrophil-predominant) inflammation. The effect of intestinal eosinophils on IBD outcomes remains unclear. Read More

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http://dx.doi.org/10.1136/bmjgast-2020-000373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039632PMC
February 2020

Utility of the methylated SEPT9 test for the early detection of colorectal cancer: a systematic review and meta-analysis of diagnostic test accuracy.

BMJ Open Gastroenterol 2020 18;7(1):e000355. Epub 2020 Feb 18.

Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Circulating tumour DNA from colorectal cancer (CRC) is a biomarker for early detection of the disease and therefore potentially useful for screening. One such biomarker is the methylated SEPT9 (mSEPT9) gene, which occurs during CRC tumourigenesis. This systematic review and meta-analysis aims to establish the sensitivity, specificity and accuracy of mSEPT9 tests for the early diagnosis of CRC. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039590PMC
February 2020

Colorectal cancer outcomes after screening with the multi-target stool DNA assay: protocol for a large-scale, prospective cohort study (the Voyage study).

BMJ Open Gastroenterol 2020 19;7(1):e000353. Epub 2020 Feb 19.

Robert D. and Patricia E. Kern Center for the Science of Healthcare Delivery, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: Population-level screening has been shown to reduce the incidence and mortality of colorectal cancer (CRC). Unfortunately, adherence to screening recommendations among eligible US adults remains below national goals. A relatively new non-invasive screening modality, the Food and Drug Administration-approved multi-target stool DNA (mt-sDNA) assay (commercialised as Cologuard), which combines the detection of haemoglobin and DNA abnormalities, has been completed by more than 3 million individuals. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039604PMC
February 2020

Risk factors of perioperative mortality from complicated peptic ulcer disease in Africa: systematic review and meta-analysis.

BMJ Open Gastroenterol 2020 17;7(1):e000350. Epub 2020 Feb 17.

Department of Surgery, Penn State Hershey College of Medicine and Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Introduction: In 2013, peptic ulcer disease (PUD) caused over 300 000 deaths globally. Low-income and middle-income countries are disproportionately affected. However, there is limited information regarding risk factors of perioperative mortality rates in these countries. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039611PMC
February 2020

Practice recommendations for the use of sedation in routine hospital-based colonoscopy.

BMJ Open Gastroenterol 2020 16;7(1):e000348. Epub 2020 Feb 16.

Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Objective: Although sedation improves patient experience during colonoscopy, there is great jurisdictional variability in sedative practices. The objective of this study was to develop practice recommendations for the use of moderate and deep sedation in routine hospital-based colonoscopy to facilitate standardisation of practice.

Design: We recruited 32 multidisciplinary panellists to participate in a modified Delphi process to establish consensus-based recommendations for the use of sedation in colonoscopy. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039579PMC
February 2020

Effectiveness of phosphatidylcholine in alleviating steatosis in patients with non-alcoholic fatty liver disease and cardiometabolic comorbidities (MANPOWER study).

BMJ Open Gastroenterol 2020 13;7(1):e000341. Epub 2020 Jan 13.

Medical Affairs, Sanofi-Aventis SA, Moscow, Russian Federation.

Objective: The concept of using naturally occurring compounds such as polyenylphosphatidylcholine (PPC) as an adjunctive therapy to treat non-alcoholic fatty liver disease (NAFLD) and alleviate or reverse hepatic steatosis appears a very attractive option for liver protection. We aim to evaluate if PPC adjunctive therapy can effectively improve the ultrasonographic features of NAFLD in routine clinical practice in Russian patients with cardiometabolic comorbidities.

Design: This 24-week, observational, prospective study was carried out in 174 medical sites across 6 federal districts of Russia. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011021PMC
January 2020

Correction: Use of ethylene-oxide gas sterilisation to terminate multidrug-resistant bacterial outbreaks linked to duodenoscopes.

Authors:

BMJ Open Gastroenterol 2019;6(1):e000282corr1. Epub 2019 Dec 30.

[This corrects the article DOI: 10.1136/bmjgast-2019-000282.]. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000282corr1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936549PMC
December 2019

Gallstone ileus: a review.

Authors:
Koichi Inukai

BMJ Open Gastroenterol 2019 24;6(1):e000344. Epub 2019 Nov 24.

Department of Acute Care Surgery, Sakai City Medical Center, Sakai, Osaka, Japan.

Gallstone ileus is an important complication of cholecystolithiasis. In general, surgery is the treatment of choice for such cases, but clinicians face difficulty in the selection of an appropriate approach. Closure of a cholecystoenteric fistula can be achieved through one-stage or two-stage operation. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904169PMC
November 2019

Development of a national Department of Veterans Affairs mortality risk prediction model among patients with cirrhosis.

BMJ Open Gastroenterol 2019 26;6(1):e000342. Epub 2019 Nov 26.

Veteran's Health Administration, VA Tennessee Valley Healthcare System, Nashville, Tennessee, USA.

Objective: Cirrhotic patients are at high hospitalisation risk with subsequent high mortality. Current risk prediction models have varied performances with methodological room for improvement. We used current analytical techniques using automatically extractable variables from the electronic health record (EHR) to develop and validate a posthospitalisation mortality risk score for cirrhotic patients and compared performance with the model for end-stage liver disease (MELD), model for end-stage liver disease with sodium (MELD-Na), and the CLIF Consortium Acute Decompensation (CLIF-C AD) models. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904155PMC
November 2019

Combined effect of modifiable and non-modifiable risk factors for colorectal cancer risk in a pooled analysis of 11 population-based studies.

BMJ Open Gastroenterol 2019 2;6(1):e000339. Epub 2019 Dec 2.

Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Objective: 'Environmental' factors associated with colorectal cancer (CRC) risk include modifiable and non-modifiable variables. Whether those with different non-modifiable baseline risks will benefit similarly from reducing their modifiable CRC risks remains unclear.

Design: Using 7945 cases and 8893 controls from 11 population-based studies, we combined 17 risk factors to characterise the overall environmental predisposition to CRC (environmental risk score (E-score)). Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904202PMC
December 2019

Adult-onset autoimmune-type enteropathy: potential relationship to an adverse drug reaction.

BMJ Open Gastroenterol 2019 2;6(1):e000319. Epub 2019 Dec 2.

University Health Network, Toronto, Ontario, Canada.

Objective: To describe an example of adult-onset autoimmune enteropathy (AIE) that coincided with drug-induced reaction.

Design: A 54-year-old patient was presented with Stevens-Johnson syndrome after a course of quinolones. This was followed shortly thereafter by epigastric pain, diarrhoea and weight loss. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904145PMC
December 2019

Volumetric laser endomicroscopy features of dysplasia at the gastric cardia in Barrett's oesophagus: results from an observational cohort study.

BMJ Open Gastroenterol 2019 23;6(1):e000340. Epub 2019 Oct 23.

Division of Gastroenterology, Zucker School of Medicine at Hofstra/Northwell, Long Island Jewish Medical Center, Northwell Health System, New Hyde Park, New York, USA.

Objective: Volumetric laser endomicroscopy (VLE) is an advanced imaging modality used in Barrett's oesophagus (BE) to help identify dysplasia in the oesophagus. VLE criteria exist for oesophageal dysplasia but not for dysplasia in the gastric cardia. The aim of this study was to determine if there are in vivo VLE features that can predict gastric cardia dysplasia in BE. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827805PMC
October 2019

Competing mortality risks analysis of prediagnostic lifestyle and dietary factors in colorectal cancer survival: the Norwegian Women and Cancer Study.

BMJ Open Gastroenterol 2019 30;6(1):e000338. Epub 2019 Oct 30.

Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.

Background: It remains unclear whether or which prediagnostic lifestyle and dietary factors influence colorectal cancer (CRC) survival following diagnosis. This study used competing mortality risks analysis to evaluate the association between these factors and CRC survival.

Methods: A total of 96 889 cancer-free participants of the Norwegian Women and Cancer Study completed the study's baseline questionnaire on lifestyle and dietary factors between 1996 and 2004. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827763PMC
October 2019

Validation of Novel Fibrosis Index (NFI) for assessment of liver fibrosis: comparison with transient elastography (FibroScan).

BMJ Open Gastroenterol 2019 18;6(1):e000316. Epub 2019 Oct 18.

Ameer-ud-Din Medical College, PGMI, Lahore, Pakistan.

Background: In this study, we collated cheap and readily available non-invasive biomarkers and FibroScan score in predicting fibrosis stages in chronic hepatitis C virus (HCV) infection.

Methods: We studied 1898 patients with HCV infection confirmed by presence of HCV RNA in their serum. We compared the FibroScan score and fibrosis indices (FIs): aspartate transaminase (AST) to alanine transaminase (ALT) ratio (AAR), AST to Platelet Ratio Index (APRI), FI, fibrosis-4 (FIB-4), Age-Platelet Index (API), Pohl score, Fibrosis Cirrhosis Index (FCI). Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827736PMC
October 2019

Endoscopic ultrasound in the assessment of advanced duodenal adenomatosis in familial adenomatous polyposis.

BMJ Open Gastroenterol 2019 20;6(1):e000336. Epub 2019 Sep 20.

Institute for Liver & Digestive Health, University College London, London, UK.

Objective: Current surveillance strategies for duodenal adenomatosis in familial adenomatous polyposis (FAP) miss malignancies and underestimate cancer risk in ampullary disease. This study aimed to evaluate the utility of endoscopic ultrasound (EUS) in the assessment of FAP patients with duodenal and/or ampullary polyposis referred for surgical intervention.

Design: A retrospective analysis of FAP patients undergoing index EUS between December 2006 and May 2015 was performed. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781957PMC
September 2019

Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population.

BMJ Open Gastroenterol 2019 9;6(1):e000330. Epub 2019 Sep 9.

Faculty of Medicine and Medical Sciences, University of Balamand, El-Koura, Lebanon.

Objective: Correa's cascade is a 'Model for Gastric Cancer Development' described by Peleyo Correa. The reversibility of Correa's cascade remains debatable. The literature contains insufficient data on the specific stage of the cascade during which is detected, treated, and the effect on prognosis. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781958PMC
September 2019
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Relationship between expressing Cnm in the oral cavity and non-alcoholic steatohepatitis: a pilot study.

BMJ Open Gastroenterol 2019 1;6(1):e000329. Epub 2019 Oct 1.

Department of Pediatric Dentistry, Division of Oral Infection and Disease Control, Osaka University School of Dentistry Graduate School of Dentistry, Suita, Japan.

Background: Non-alcoholic steatohepatitis (NASH) is a severe state of non-alcoholic fatty liver disease (NAFLD), which is pathologically characterised by steatosis, hepatocyte ballooning, and lobular inflammation. Host-microbial interaction has gained attention as one of the risk factors for NASH. Recently, -gene positive expressing cell surface collagen-binding protein, Cnm (-positive ), was shown to aggravate NASH in model mice. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781959PMC
October 2019

Gastrointestinal lymphoma: the new mimic.

BMJ Open Gastroenterol 2019 13;6(1):e000320. Epub 2019 Sep 13.

Hepatology and Nutrition, Houston Methodist Hospital, Houston, Texas, USA.

Background: Gastrointestinal (GI) lymphomas comprise a group of distinct clinicopathological entities of B- or T- cell type, with primary gastrointestinal Hodgkin lymphoma being extremely uncommon. The GI tract is the predominant site of extranodal non-Hodgkin lymphoma accounting for 30-40% of all extranodal lymphomas. In the Western world, the stomach is the most commonly involved site followed by the small bowel. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782046PMC
September 2019
5 Reads