170 results match your criteria BMJ open gastroenterology[Journal]


Novel mainstream capnometer system is safe and feasible even under CO insufflation during ERCP-related procedure: a pilot study.

BMJ Open Gastroenterol 2019 28;6(1):e000266. Epub 2019 Feb 28.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Background And Aims: There is a need to safely achieve conscious sedation during endoscopic retrograde cholangiopancreatography (ERCP). We evaluated the safety and feasibility of a mainstream capnometer system to monitor apnoea during ERCP under CO insufflation.

Methods: Non-intubated adult patients undergoing ERCP-related procedures with intravenous sedation were enrolled. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398869PMC
February 2019
1 Read

Cytomegalovirus colitis in inflammatory bowel disease and after haematopoietic stem cell transplantation: diagnostic accuracy, predictors, risk factors and disease outcome.

BMJ Open Gastroenterol 2019 27;6(1):e000258. Epub 2019 Feb 27.

Department of Gastroenterology and Gastrointestinal Oncology, Universitatsklinikum Gottingen, Gottingen, Germany.

Background: Concurrent cytomegalovirus (CMV) colitis in inflammatory bowel disease (IBD) and after haematopoietic stem cell transplantation (HSCT) is an important clinical entity associated with high rates of morbidity and mortality.

Methods: A retrospective study of 47 patients with IBD and 61 HSCT patients was performed regarding the evaluation of diagnostic accuracy of applied methods, predictors, risk factors for CMV disease manifestation, the proportion of patients with antiviral treatment and disease outcome.

Results: The sensitivity of quantitative PCR (qPCR) with a cut-off value of >250 copies/mg for CMV colitis in patients with IBD and HSCT patients was 79% and 92%, respectively. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398871PMC
February 2019
2 Reads

Body image dissatisfaction in patients with inflammatory bowel disease: a systematic review.

BMJ Open Gastroenterol 2019 16;6(1):e000255. Epub 2019 Feb 16.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background And Aims: Little is known about the relationship between inflammatory bowel disease (IBD) and body image. The aim of this systematic review was to summarise the evidence on body image dissatisfaction in patients with IBD across four areas: (1) body image tools, (2) prevalence, (3) factors associated with body image dissatisfaction in IBD and (4) association between IBD and quality of life.

Methods: Two reviewers screened, selected, quality assessed and extracted data from studies in duplicate. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398870PMC
February 2019

Successful use of TNFα blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura.

BMJ Open Gastroenterol 2019 8;6(1):e000252. Epub 2019 Feb 8.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

We describe the case of 50-year-old female patient who presented with severe gastrointestinal symptoms and progressive weight loss of unknown origin. Shortly after admission, she developed an acute flare of thrombotic thrombocytopaenic purpura (TTP) that had to be treated by plasma exchange therapy and rituximab administration. While the signs of TTP subsided, the gastrointestinal symptoms worsened with abdominal cramps, massive gastric retention, malnourishment and a stenosis due to extensive inflammation and wall thickening of the small bowel. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398868PMC
February 2019
1 Read

Moderately severe and severe acute pancreatitis : a systematic review of the outcomes in the USA and European Union-5.

BMJ Open Gastroenterol 2019 16;6(1):e000248. Epub 2019 Feb 16.

Global Outcomes Research, Takeda, London, UK.

Background And Objectives: The global incidence of hospitalisation due to acute pancreatitis (AP) has been rising in the recent decades. In the USA alone, there was a 13.2% increase between 2009 and 2012 compared with 2002-2005. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398872PMC
February 2019

Gut microbiome meta-analysis reveals dysbiosis is independent of body mass index in predicting risk of obesity-associated CRC.

BMJ Open Gastroenterol 2019 28;6(1):e000247. Epub 2019 Feb 28.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, New York, USA.

Objective: Obesity is a risk factor for colorectal cancer (CRC), accounting for more than 14% of CRC incidence. Microbial dysbiosis and chronic inflammation are common characteristics in both obesity and CRC. Human and murine studies, together, demonstrate the significant impact of the microbiome in governing energy metabolism and CRC development; yet, little is understood about the contribution of the microbiome to development of obesity-associated CRC as compared to individuals who are not obese. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398873PMC
February 2019
1 Read

Mutational load may predict risk of progression in patients with Barrett's oesophagus and indefinite for dysplasia: a pilot study.

BMJ Open Gastroenterol 2019 2;6(1):e000268. Epub 2019 Feb 2.

Division of Pathology, Zucker School of Medicine at Hofstra/Northwell, Long Island Jewish Medical Center, Northwell Health System, New Hyde Park, New York, USA.

Background And Aims: Mutational load (ML) has been shown to help risk-stratify those that may progress from non-dysplastic Barrett's oesophagus (BE) to dysplastic disease. Management of patients with BE and indefinite for dysplasia (BE-IND) is challenging and risk stratification tools are lacking. The aim of this pilot study is to evaluate the utility of ML for risk stratification in patients with BE-IND. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361327PMC
February 2019

Practical strategies for pruritus management in the obeticholic acid-treated patient with PBC: proceedings from the 2018 expert panel.

BMJ Open Gastroenterol 2019 1;6(1):e000256. Epub 2019 Feb 1.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.

Background And Aims: This article provides expert guidance on the management of pruritus symptoms in patients receiving obeticholic acid (OCA) as treatment for primary biliary cholangitis (PBC). PBC is a chronic, autoimmune cholestatic liver disease that affects intrahepatic bile ducts. If not adequately treated, PBC can lead to cholestasis and end-stage liver disease, which may require transplant. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361341PMC
February 2019
4 Reads

Genetic polymorphisms in tumour necrosis factor receptors () illustrate differential treatment response to TNFα inhibitors in patients with Crohn's disease.

BMJ Open Gastroenterol 2019 1;6(1):e000246. Epub 2019 Feb 1.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA.

Background: Monoclonal antibodies inhibiting tumour necrosis factor-α (TNFα) signalling pathway (anti-TNFα) have been widely used in Crohn's disease (CD). However, treatment response varies among patients with CD and the clinical outcome is dependent on single nucleotide polymorphisms (SNP) in TNFα receptor superfamily 1A and 1B ().

Methods: We tested nine SNPs in and by TaqMan genotyping from peripheral blood samples of 104 subjects. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361334PMC
February 2019

Role for structured telephone clinics in paediatric gastroenterology: reflections, lessons and patient feedback.

BMJ Open Gastroenterol 2019 2;6(1):e000245. Epub 2019 Feb 2.

Paediatric Gastroenterology Department, The Royal Hospital for Children, Glasgow, UK.

Background: Telephone clinics have been established within our department to try and improve communication with families, limit waiting times and help face-to-face clinics run more efficiently. As part of the ongoing care needs for our patients and families it was felt important to determine if telephone clinics were meeting the needs of the young person and family as well as those of the health professional.

Objective: To assess the effects of a structured consultant delivered telephone clinic. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361335PMC
February 2019

Evaluation of the combined effect of factors influencing bowel preparation and adenoma detection rates in patients undergoing colonoscopy.

BMJ Open Gastroenterol 2019 24;6(1):e000254. Epub 2019 Jan 24.

Department of Medicine, BronxCare Health System, New York City, New York, USA.

Background: Colonoscopy is a commonly used modality for screening and surveillance of colorectal cancer (CRC). Therefore, it is essential to have adequate bowel preparation (prep) for the procedure which depends on type of bowel regimens, diet before colonoscopy and timing of the procedure.

Aims: The purpose of this study is to analyse the effect of multiple factors on adenoma detection rate (ADR) and prep quality of colonoscopy. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347943PMC
January 2019
7 Reads

Correction: .

Authors:

BMJ Open Gastroenterol 2018 30;5(1):e000232corr1. Epub 2018 Dec 30.

[This corrects the article DOI: 10.1136/bmjgast-2018-000232.]. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000232corr1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326290PMC
December 2018

Adenoma Detection before and after the age of 50: a retrospective analysis of Lebanese outpatients.

BMJ Open Gastroenterol 2018 28;5(1):e000253. Epub 2018 Nov 28.

Department of Gastroenterology, Saint George Hospital University Medical Center, Beirut, Lebanon.

Background And Aim: Colorectal cancer (CRC) has an increased impact on the Lebanese population's morbidity and mortality. This study evaluated the situation of adenoma detection in an outpatient clinic in Lebanon.

Patients And Methods: 918 patients underwent colonoscopy over a period of 24 months by a qualified physician. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280908PMC
November 2018
2 Reads

Interference with the lower gut-liver axis induces remission of primary sclerosing cholangitis in a patient with ulcerative colitis.

BMJ Open Gastroenterol 2018 14;5(1):e000239. Epub 2018 Nov 14.

Department of Gastroenterology, Bedford Hospital South Wing, Bedford, UK.

The gut-liver axis describes the complex interactions between gut microbiota, the small and large bowel, the immune system and the liver. Current evidence associates abnormalities within the gut-liver axis with liver disease such as primary sclerosing cholangitis (PSC). PSC is believed to be an immune-mediated disease though the exact mechanism of its pathogenesis remains unknown. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267462PMC
November 2018
2 Reads

Safety of dual biological therapy in Crohn's disease: a case series of vedolizumab in combination with other biologics.

BMJ Open Gastroenterol 2018 9;5(1):e000243. Epub 2018 Nov 9.

Department of Medicine, Division of Gastroenterology, University of California, San Francisco, San Francisco, California, USA.

Uncertainty exists regarding safety and efficacy of dual biological therapy (DBT) in inflammatory bowel disease. We present four cases of DBT in Crohn's disease. Three patients had refractory disease non-responsive to biological monotherapy or combination therapy with immunomodulators. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254738PMC
November 2018
2 Reads

School-related experience and performance with inflammatory bowel disease: results from a cross-sectional survey in 675 children and their parents.

BMJ Open Gastroenterol 2018 24;5(1):e000236. Epub 2018 Nov 24.

Division of Epidemiology and Biometry, Medical Faculty, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Objective: We describe school performance and experience in children with inflammatory bowel disease (IBD) across Germany and Austria. Predictors of compromised performance and satisfaction were evaluated to identify subgroups of increased risk.

Design: This cross-sectional analysis was based on a postal survey in children aged 10-15 with Crohn's disease, ulcerative colitis or unclassified IBD and their families. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254744PMC
November 2018
1 Read

Feasibility of collecting and assessing patient-reported outcomes for emergency admissions: laparotomy for gastrointestinal conditions.

BMJ Open Gastroenterol 2018 16;5(1):e000238. Epub 2018 Oct 16.

Departement of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.

Introduction: Audit of emergency surgery is usually limited to immediate clinical outcomes relating to outcomes during the acute hospital episode with little attempt to capture patients' views of their longer-term outcomes. Our aim was to determine the response rate to patient-reported outcome measures (PROMs) for patients who underwent an emergency laparotomy for gastrointestinal conditions, identify response bias and explore the feasibility of comparing outcomes with their prior health based on their recalled view collected during their admission.

Methods: Patients undergoing emergency laparotomy in 11 hospitals were recruited to complete a retrospective questionnaire containing the EQ-5D-3L and Gastrointestinal Quality of Life Index (GIQLI). Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203065PMC
October 2018
11 Reads

Five-year single-centre experience of carcinoma of the oesophagus from Blantyre, Malawi.

BMJ Open Gastroenterol 2018 15;5(1):e000232. Epub 2018 Oct 15.

Department of Medicine, Queen Elizabeth Central Hospital, Blantyre, Malawi.

Background: Oesophageal squamous cell carcinoma (OSCC) is increasing worldwide and has an exceptionally high prevalence in certain distinct geographical locations such as the African oesophageal SCC corridor. Despite this, there is a paucity of evidence to characterise the disease particularly in the Malawian context.

Method: We retrospectively audited our endoscopy database over 5 years, including for patient demographics, endoscopy findings, therapeutic intervention and recommendations for treatment. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203015PMC
October 2018
10 Reads

A male Korean who was diagnosed with chronic enteropathy associated with (CEAS): case report with literature review.

BMJ Open Gastroenterol 2018 23;5(1):e000223. Epub 2018 Oct 23.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Objective: To further disseminate the nomenclature of chronic enteropathy associated with SLCO2A1 (CEAS), especially for physicians in China and Korea where the genetic feature of gene mutations related hypertrophic osteoarthropathy and pachydermia had been extensively studied. gene mutations related hypertrophic osteoarthropathy and pachydermia had been extensively studied.

Design: A case report with literature review of gene mutations-related disorders. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202987PMC
October 2018
10 Reads

Discharge of patients with an acute upper gastrointestinal bleed from the emergency department using an extended Glasgow-Blatchford Score.

BMJ Open Gastroenterol 2018 30;5(1):e000225. Epub 2018 Aug 30.

Department of Gastroenterology, Imperial College Healthcare and Imperial College London, London, UK.

Objective: To use an extended Glasgow-Blatchford Score (GBS) cut-off of ≤1 to aid discharge of patients presenting with acute upper gastrointestinal bleeding (AUGIB) from emergency departments.

Background: The GBS accurately predicts the need for intervention and death in AUGIB, and a cut-off of 0 is recommended to identify patients for discharge without endoscopy. However, this cut-off is limited by identifying a low percentage of low-risk patients. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135483PMC
August 2018
3 Reads

Systematic review and meta-analysis: real-world effectiveness of direct-acting antiviral therapies in chronic hepatitis C genotype 3 in Asia.

BMJ Open Gastroenterol 2018 20;5(1):e000209. Epub 2018 Aug 20.

Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.

Background: Genotype 3 (GT3) is a common chronic hepatitis C (CHC) genotype in Asia. Direct-acting antiviral (DAA) regimens have high cure rates, but real-world results are limited for Asia.

Aim: To determine the real-world effectiveness of DAAs for patients with CHC GT3 in Asia. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104766PMC
August 2018
4 Reads

Diagnostic accuracy of a pH stick, modified to detect gastric lipase, to confirm the correct placement of nasogastric tubes.

BMJ Open Gastroenterol 2018 31;5(1):e000218. Epub 2018 Jul 31.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Objective: The correct placement of a nasogastric feeding tube is usually confirmed by establishing that an aspirate is acidic using a pH stick. However, antacid medication and achlorhydria can cause false negative pH tests that may delay feeding and increase resource use. The purpose of this study was to evaluate a modified pH stick designed to detect gastric lipase and therefore reduce false negative tests. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089299PMC
July 2018
21 Reads

Growth patterns of colorectal cancer liver metastases and their impact on prognosis: a systematic review.

BMJ Open Gastroenterol 2018 27;5(1):e000217. Epub 2018 Jul 27.

Department of Biosciences and Nutrition, NEO, Karolinska Institutet, Huddinge, Sweden.

Background: Colorectal cancer liver metastases (CRLM) grow in distinct histological patterns that have been associated with outcome after surgical resection. We conducted a systematic review to evaluate the frequency of different CRLM growth patterns and their impact on prognosis.

Methods: We searched Embase and MEDLINE databases from inception to 1 December 2017 to identify studies that reported CRLM growth pattern histopathology, their frequencies, and/or data related to outcome. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067357PMC
July 2018
11 Reads

TNFα inhibitors exacerbate infection in tissue culture: a rationale for poor response of patients with Crohn's disease to current approved therapy.

BMJ Open Gastroenterol 2018 15;5(1):e000216. Epub 2018 Jul 15.

Burnett School of Biomedical Sciences, Division of Molecular Microbiology, College of Medicine, University of Central Florida, Orlando, Florida, USA.

The role of subspecies (MAP) in Crohn's disease (CD) is increasingly accepted as evident by detection of the bacteria in the blood and intestinal tissue from patients with CD, and by supporting data from several open-label anti-MAP treatment studies. Tumour necrosis factor alpha (TNFα) monoclonal antibodies (anti-TNFα) have been widely used for CD treatment. Despite the short-term benefit of anti-TNFα in controlling CD symptoms, most patients suffer from detrimental adverse effects, including higher susceptibility to mycobacterial infections. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067372PMC

Clinical and manometric characteristics of patients with oesophagogastric outflow obstruction: towards a new classification.

BMJ Open Gastroenterol 2018 25;5(1):e000210. Epub 2018 Jul 25.

Stanford Esophageal Multi-disciplinary Program in Innovative Research Excellence (SEMPIRE), Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.

Background: The Chicago Classification (CC) defines oesophagogastric junction outflow obstruction (EGJOO) as the presence of an elevated integrated residual pressure (IRP) together with preserved oesophageal body peristalsis but its clinical significance is evolving.

Aims: To describe the clinical and manometric characteristics in patients with EGJOO and propose a new classification.

Methods: In this retrospective cohort study, patients with functional oesophageal symptoms underwent clinical and endoscopic assessment and oesophageal high-resolution manometry (HRM). Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067397PMC
July 2018
15 Reads

Golimumab induction and maintenance for moderate to severe ulcerative colitis: results from GO-COLITIS (Golimumab: a Phase 4, UK, open label, single arm study on its utilization and impact in ulcerative Colitis).

BMJ Open Gastroenterol 2018 7;5(1):e000212. Epub 2018 Jul 7.

Department of Gastroenterology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.

Objective: GO-COLITIS aimed to measure the effectiveness of subcutaneous golimumab in tumour necrosis factor-α antagonist-naive patients with moderate to severe ulcerative colitis (UC) despite conventional treatment.

Design: GO-COLITIS was an open label, single arm, phase 4 study with a pragmatic design which reflected UK clinical practice. Adult patients were eligible if diagnosed with UC ≥3 months, partial Mayo score (PMS) 4-9. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038835PMC
July 2018
4 Reads

Real-world effectiveness of sofosbuvir plus ribavirin for chronic hepatitis C genotype 2 in Asia: a systematic review and meta-analysis.

BMJ Open Gastroenterol 2018 29;5(1):e000207. Epub 2018 Jun 29.

Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, California, USA.

Background: Sofosbuvir plus ribavirin (SOF+RBV) for 12 weeks is the standard treatment for chronic hepatitis C (CHC) genotype 2 (GT2) in most of Asia despite availability of new CHC medications. SOF-RBV real-world effectiveness has only been reported in small and/or single-centre studies. Our goal was to determine the real-world effectiveness of 12-week SOF+RBV therapy for CHC GT2 in Asia. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038840PMC
June 2018
11 Reads

Study to determine the likely accuracy of pH testing to confirm nasogastric tube placement.

BMJ Open Gastroenterol 2018 9;5(1):e000211. Epub 2018 Jun 9.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Objective: To establish the likely accuracy of pH testing to identify gastric aspirates at different pH cut-offs to confirm nasogastric tube placement.

Methods: This prospective observational study included a convenience sample of adult patients who had two (one fresh and one frozen) gastric and oesophageal samples taken during gastroscopy or two bronchial and saliva samples taken during bronchoscopy. The degree of observer agreement for the pH of fresh and frozen samples was indicted by kappa () statistics. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001908PMC
June 2018
1 Read

Putative biomarkers of vedolizumab resistance and underlying inflammatory pathways involved in IBD.

BMJ Open Gastroenterol 2018 31;5(1):e000208. Epub 2018 May 31.

Department of Gasteroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev, Denmark.

Objectives: Characterise the circulating inflammatory cytokine pattern among patients failing consecutive anti-tumour necrosis factor (anti-TNF) and anti-integrin treatments to identify predictors of response.

Methods: A retrospective single-centre cohort study of 28 patients with inflammatory bowel disease (IBD) receiving anti-integrin therapy (vedolizumab) subsequent to the failure of anti-TNF treatment was conducted. Blood samples were obtained immediately prior to initiation of vedolizumab therapy, and the response to treatment was evaluated after completion of the 14-week induction regimen. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001911PMC
May 2018
8 Reads

Evaluation of amnion-derived mesenchymal stem cells for treatment-resistant moderate Crohn's disease: study protocol for a phase I/II, dual-centre, open-label, uncontrolled, dose-response trial.

BMJ Open Gastroenterol 2018 31;5(1):e000206. Epub 2018 May 31.

Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Introduction: The medical treatment options for patients with Crohn's disease (CD) are limited and patients resistant to those therapies are left requiring surgical operations that usually only achieve some symptomatic relief. Mesenchymal stem cells (MSC) have been shown to be effective for the treatment of CD, and we have demonstrated in animal experiments that human amnion-derived MSCs (AMSC) are a potential new therapeutic strategy. Therefore, we designed this study to investigate the safety and efficacy of AMSCs in patients with treatment-resistant CD. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001910PMC
May 2018
11 Reads

Peribiliary cysts: a systematic review and proposal of a classification framework.

BMJ Open Gastroenterol 2018 6;5(1):e000204. Epub 2018 Jun 6.

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Objective: Peribiliary cysts are usually benign, although severe complications and mortality may occur, and they may be confounded with other diseases. No classification delineating their different characteristics exists.

Design: We performed a systematic review of the frequency and clinical manifestations of peribiliary cysts. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001913PMC
June 2018
5 Reads

Autoantibodies in chronic hepatitis C virus infection: impact on clinical outcomes and extrahepatic manifestations.

BMJ Open Gastroenterol 2018 5;5(1):e000203. Epub 2018 May 5.

Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, California, USA.

Goals: To examine the role that autoantibodies (auto-abs) play in chronic hepatitis C virus (HCV) regarding demographics, presence of extrahepatic manifestations and long-term outcomes in a large US cohort.

Background: Auto-abs have been reported to be prevalent in patients with chronic HCV infection, but data on the natural history of these patients are limited.

Study: The study included 1556 consecutive patients with HCV without concurrent HIV and/or HBV who had testing for antinuclear antibody (ANA), antimitochondrial antibody (AMA), antismooth muscle antibody (ASMA) and/or antiliver kidney microsomal antibody (LKM). Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942460PMC
May 2018
5 Reads

Mortality in coeliac disease: a population-based cohort study from a single centre in Southern Derbyshire, UK.

BMJ Open Gastroenterol 2018 17;5(1):e000201. Epub 2018 Apr 17.

Department of Public Health, Derby City Council, Derby, UK.

Objective: With the advent of screening tests, it was hypothesised that milder cases of coeliac disease coming to diagnosis might have reduced risk of mortality. An earlier publication did not support this view. We have re-examined this issue employing a larger number of patients followed for a further 8 years. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911148PMC

Non-alcoholic steatofibrosis (NASF) can independently predict mortality in patients with non-alcoholic fatty liver disease (NAFLD).

BMJ Open Gastroenterol 2018 20;5(1):e000198. Epub 2018 Mar 20.

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA.

Background: Hepatic fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) independently predicts mortality. Given liver biopsy's invasive nature, non-invasive method to assess hepatic steatosis and fibrosis provides NAFLD risk stratification algorithm in clinical practice. NAFLD fibrosis score (NFS) is simple and non-invasive predictive model recommended by American Association for the Study of Liver Disease (AASLD) Guideline to identify patients with NAFLD with fibrosis risk. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873539PMC
March 2018
19 Reads

Rate of hepatocellular carcinoma surveillance remains low for a large, real-life cohort of patients with hepatitis C cirrhosis.

BMJ Open Gastroenterol 2018 20;5(1):e000192. Epub 2018 Mar 20.

Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, California, USA.

Background: In patients with chronic hepatitis C (CHC) cirrhosis, imaging for hepatocellular carcinoma (HCC) is recommended every 6 months to maximise eligibility for curative treatment. The aim was to determine the adherence rate and outcomes among patients with CHC cirrhosis and whether the adherence rate has improved over time.

Methods: Retrospective cohort study of patients with CHC cirrhosis (n=2366) monitored for ≥1 year at Stanford University Medical Center between January 2001 and August 2015. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2017
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http://dx.doi.org/10.1136/bmjgast-2017-000192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873543PMC
March 2018
7 Reads

Changing nationwide trends in endoscopic, medical and surgical admissions for inflammatory bowel disease: 2003-2013.

BMJ Open Gastroenterol 2018 20;5(1):e000191. Epub 2018 Mar 20.

Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust and St George's University of London, London, UK.

Background And Study Aims: In the last decade, there have been major advances in inflammatory bowel disease (IBD) management but their impact on hospital admissions requires evaluation. We aim to investigate nationwide trends in IBD surgical/medical elective and emergency admissions, including endoscopy and cytokine inhibitor infusions, between 2003 and 2013.

Patients And Methods: We used Hospital Episode Statistics and population data from the UK Office for National Statistics. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873541PMC
March 2018
2 Reads

Study for every other day administration of vonoprazan in maintenance treatment of erosive GERD: study protocol for a multicentre randomised cross-over study.

BMJ Open Gastroenterol 2018 16;5(1):e000197. Epub 2018 Feb 16.

Department of Gastroenterology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.

Introduction: The first drug selected for treatment of gastro-oesophageal reflux disease (GERD) and prevention of the recurrence is a proton pump inhibitor (PPI), but recently, a potassium-competitive acid blocker (P-CAB) was put on the market in Japan. Its onset of effect is faster than PPI, and it takes more than 2 days to recover acid secretion after the withdrawal period. Therefore, unlike PPI, the usefulness of every other day administration or discontinuous administration is expected. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841500PMC
February 2018
5 Reads

Implication of exercise interventions on sleep disturbance in patients with pancreatic cancer: a study protocol for a randomised controlled trial.

BMJ Open Gastroenterol 2018 16;5(1):e000196. Epub 2018 Feb 16.

Department of Internal Medicine, Division of Hepatobiliary and Pancreatic Disease, Hyogo College of Medicine, Nishinomiya, Japan.

Introduction And Purpose: Patients with pancreatic cancer (PC) have long been known to have high rates of depression. Depression in patients with PC can be linked to sleep disturbance. The American College of Sports Medicine notes that physical exercise is safe for most patients with cancer and physical inactivity should be avoided. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841532PMC
February 2018
3 Reads

Outcome of tacrolimus and vedolizumab after corticosteroid and anti-TNF failure in paediatric severe colitis.

BMJ Open Gastroenterol 2018 14;5(1):e000195. Epub 2018 Feb 14.

Department of Pediatrics, Stanford Children's Inflammatory Bowel Disease Center, Division of Gastroenterology, Stanford University School of Medicine, Stanford, California, USA.

Background: Severe colitis flare from ulcerative colitis (UC) or Crohn's disease (CD) may be refractory to corticosteroids and antitumour necrosis factor (TNF) agents resulting in high colectomy rates. We aimed to describe the utility of tacrolimus to prevent colectomy during second-line vedolizumab initiation after corticosteroid and anti-TNF treatment failure in paediatric severe colitis.

Methods: A retrospective cohort analysis was performed between 1 October 2014 and 31 October 2016 at a single tertiary care centre. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841492PMC
February 2018
6 Reads

Effect of exercise therapy on sarcopenia in pancreatic cancer: a study protocol for a randomised controlled trial.

BMJ Open Gastroenterol 2018 7;5(1):e000194. Epub 2018 Feb 7.

Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Introduction And Purpose: Sarcopenia is defined as a decrease in muscle mass and muscle strength, and it has been demonstrated to be an adverse predictor in numerous types of cancers. Exercise therapy (ET) carries multiple health benefits in several diseases. Despite these clinical benefits, there are limited data available regarding patients with pancreatic cancer (PC) undergoing ET. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841516PMC
February 2018
9 Reads

Clinical impact of physical exercise on sleep disorder as assessed by actigram in patients with chronic pancreatitis: a study protocol for a randomised controlled trial.

BMJ Open Gastroenterol 2018 14;5(1):e000193. Epub 2018 Feb 14.

Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Introduction: In most chronic pancreatitis (CP) cases, malabsorption, pain, and weight loss are the leading clinical symptoms, which significantly worsen the quality of life (QOL) and decreased QOL in patients with CP can cause sleep disorder. There is a growing body of evidence that recognises the favourable effects of physical exercise (PE), however, there are limited data currently available concerning patients with CP undergoing PE. Actigram is a device for gathering objective sleep/awake data in the natural sleeping surroundings over an extended time period. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841520PMC
February 2018
7 Reads

A randomised controlled trial of gemcitabine hydrochloride plus S-1 combination therapy versus gemcitabine hydrochloride therapy alone in pancreatic cancer patients aged ≥75 years: a study protocol for an open-label randomised feasibility study.

BMJ Open Gastroenterol 2018 11;5(1):e000187. Epub 2018 Feb 11.

Department of Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan.

Introduction: In Japan, the age of patients with pancreatic cancer has increased. Combination chemotherapies such as 5-fluorouracil/leucovorin, oxaliplatin and irinotecan therapy and gemcitabine hydrochloride (GEM) +nab paclitaxel therapy have been developed as the standard treatments for young patients with advanced recurrent pancreatic cancer. However, both therapies produce toxicity and their administration is limited by the patients' age or performance status. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841525PMC
February 2018
10 Reads

Clinicopathological and immunological characteristics and outcome of concomitant coeliac disease and non-alcoholic fatty liver disease in adults: a large prospective longitudinal study.

BMJ Open Gastroenterol 2018 29;5(1):e000150. Epub 2018 Jan 29.

Department of Immunology and Molecular Biology, American University, Cairo, Egypt.

Objective: Concomitant non-alcoholic fatty liver disease (NAFLD) and coeliac disease (CD) have not been adequately studied. This study investigated the frequency of CD among NAFLD patients and the clinicopathological and immunological patterns and outcome of concomitant NAFLD and CD.

Design: This prospective longitudinal study screened patients with NAFLD for CD (tissue transglutaminase antibodies (TTGA); anti-TTGA and antiendomysial antibodies (EMA)). Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808634PMC
January 2018
12 Reads

Protocol for a multicentred randomised controlled trial investigating the use of personalised golimumab dosing tailored to inflammatory load in ulcerative colitis: the GOAL-ARC study (GLM dose Optimisation to Adequate Levels to Achieve Response in Colitis) led by the INITIAtive group (NCT 0268772).

BMJ Open Gastroenterol 2018 11;5(1):e000174. Epub 2018 Jan 11.

Centre for Colorectal Disease, St. Vincent's University Hospital, School of Medicine, UCD, Dublin, Ireland.

Introduction: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), often leading to an impaired quality of life in affected patients. Current treatment modalities include antitumour necrosis factor (anti-TNF) monoclonal antibodies (mABs) including infliximab, adalimumab and golimumab (GLM). Several recent retrospective and prospective studies have demonstrated that fixed dosing schedules of anti-TNF agents often fails to consistently achieve adequate circulating therapeutic drug levels (DL) with consequent risk of immunogenicity treatment failure and potential risk of hospitalisation and colectomy in patients with UC. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2017
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http://dx.doi.org/10.1136/bmjgast-2017-000174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783109PMC
January 2018
9 Reads

Clinical influence of exercise therapy on sarcopenia in patients with chronic pancreatitis: a study protocol for a randomised controlled trial.

BMJ Open Gastroenterol 2018 4;5(1):e000190. Epub 2018 Jan 4.

Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Introduction And Purpose: Chronic pancreatitis (CP) involves progressive inflammatory changes to the pancreas and can lead to permanent structural damage and impairment of both endocrine and exocrine functions. Current reports highlight a rise in the incidence and prevalence of CP. However, there is limited data currently available concerning patients with CP undergoing exercise therapy (ET). Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759743PMC
January 2018
10 Reads

Familial risks for gallstones in the population of Sweden.

BMJ Open Gastroenterol 2017 29;4(1):e000188. Epub 2017 Dec 29.

Center for Primary Health Care Research, Lund University, Helsinki, Finland.

Objectives: Gallstone disease (cholelithiasis) has a familial component, but detailed data on the modification of familial risk are lacking. Using nationwide hospital and population records, we aimed to determine detailed familial risks for medically diagnosed gallstone disease.

Design: Subjects were obtained from the Multigeneration Register, which contains family data on the Swedish population, and patients with gallstone disease were identified from the Hospital Discharge Register (1964-2015) and the Outpatient Register (2001-2015). Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759740PMC
December 2017
11 Reads

Neuropsychiatric performance and treatment of hepatitis C with direct-acting antivirals: a prospective study.

BMJ Open Gastroenterol 2017 21;4(1):e000183. Epub 2017 Dec 21.

Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padova University Hospital, Padova, Italy.

Background: Since direct-acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV) infection, a small series of patients with new-onset neuropsychiatric alterations have been referred to us. We therefore set out to study neuropsychiatric function in relation to DAAs prospectively.

Methods: Ten patients with cirrhosis and 12 post-liver transplant (post-LT) patients were enrolled. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2017
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http://dx.doi.org/10.1136/bmjgast-2017-000183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759705PMC
December 2017
17 Reads

Barriers to care for chronic hepatitis C in the direct-acting antiviral era: a single-centre experience.

BMJ Open Gastroenterol 2017 20;4(1):e000181. Epub 2017 Dec 20.

Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, USA.

Background: Cure rates for chronic hepatitis C have improved dramatically with direct-acting antivirals (DAAs), but treatment barriers remain. We aimed to compare treatment initiation rates and barriers across both interferon-based and DAA-based eras.

Methods: We conducted a retrospective cohort study of all patients with chronic hepatitis C seen at an academic hepatology clinic from 1999 to 2016. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759739PMC
December 2017
26 Reads

Effect of physical exercise on sarcopaenia in patients with overt hepatic encephalopathy: a study protocol for a randomised controlled trial.

BMJ Open Gastroenterol 2017 10;4(1):e000185. Epub 2017 Dec 10.

Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Introduction: Limited data are currently available for patients with overt hepatic encephalopathy (OHE)) receiving physical exercise (PE). The aim of the current study is to prospectively examine the effect of PE on sarcopaenia in patients with OHE.

Methods And Analysis: At the time of patient recruitment, a precise assessment for nutritional status and daily physical activities will be performed in each subject. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728260PMC
December 2017
9 Reads

PCR detection of segmented filamentous bacteria in the terminal ileum of patients with ulcerative colitis.

BMJ Open Gastroenterol 2017 4;4(1):e000172. Epub 2017 Dec 4.

School of Gastroenterology, University of Ferrara, Ferrara, Italy.

Objectives: Segmented filamentous bacteria (SFB) have been detected in a wide range of different animal. Recently, the presence of SFB-like bacteria was shown in biopsies of the terminal ileum and ileocecal valve of both patients with ulcerative colitis and control subjects. The aim of this study was to verify whether PCR methods could be used for the detection of SFB in biopsy of patients with ulcerative colitis and its relationships with the disease stage. Read More

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http://dx.doi.org/10.1136/bmjgast-2017-000172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728270PMC
December 2017
13 Reads