1,834 results match your criteria BMJ open diabetes research & care[Journal]


Incidence of diabetes and prediabetes and predictors of glycemic change among South Asians in the USA: the MASALA study.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Epidemiology and Biostatistics-Diabetes Center, University of California San Francisco, San Francisco, California, USA.

Introduction: South Asians have a high prevalence of type 2 diabetes mellitus (T2DM). This may be associated with high rates of conversion through the natural history of disease. However, there is a paucity of data on prediabetes and T2DM incidence and related predictors in South Asians in the USA. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001063DOI Listing

Improving Primary Care After Stroke (IPCAS) randomised controlled trial: protocol for a multidimensional process evaluation.

BMJ Open 2020 Jul 8;10(7):e036879. Epub 2020 Jul 8.

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Introduction: Primary care interventions are often multicomponent, with several targets (eg, patients and healthcare professionals). Improving Primary Care After Stroke (IPCAS) is a novel primary care-based model of long-term stroke care involving a review of stroke-related needs, a self-management programme, a direct point of contact in general practice, enhanced communication between care services, and a directory of national and local community services, currently being evaluated in a cluster randomised controlled trial (RCT). Informed by Medical Research Council guidance for complex interventions and the Behaviour Change Consortium fidelity framework, this protocol outlines the process evaluation of IPCAS within this RCT. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-036879DOI Listing

Cohort profile: protocol and baseline survey for the Shanghai Suburban Adult Cohort and Biobank (SSACB) study.

BMJ Open 2020 Jul 8;10(7):e035430. Epub 2020 Jul 8.

Department of Health Economic, School of Public Health, Fudan University, Shanghai, China.

Purpose: The Shanghai Suburban Adult Cohort and Biobank (SSACB) was established to identify environmental, lifestyle and genetic risk factors for non-communicable chronic diseases (NCDs) in adults (20-74 years old) living in a suburban area of Shanghai with rapid urbanisation.

Participants: Two of eight suburban district were purposely selected according to participant willingness, health service facilities, population, geographic region and electronic medical record system. From these suburban districts, four communities were selected based on economic level and population size. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035430DOI Listing

Individualised risk prediction model for new-onset, progression and regression of chronic kidney disease in a retrospective cohort of patients with type 2 diabetes under primary care in Hong Kong.

BMJ Open 2020 Jul 8;10(7):e035308. Epub 2020 Jul 8.

Department of Family Medicine and Primary Healthcare, New Territory West Cluster, Hospital Authority, Hong Kong, Hong Kong.

Objectives: This study is aimed to develop and validate a prediction model for multistate transitions across different stages of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus under primary care.

Setting: We retrieved the anonymised electronic health records of a population-based retrospective cohort in Hong Kong.

Participants: A total of 26 197 patients were included in the analysis. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035308DOI Listing

Diabetes mellitus among adults with tuberculosis in the USA, 2010-2017.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Introduction: To describe diabetes trends among adults with incident tuberculosis (TB) disease and examine diabetes-associated TB characteristics and patient outcomes in the USA.

Research Design And Methods: We examined all 71 855 persons aged ≥20 years with incident TB disease reported to the National Tuberculosis Surveillance System during 2010-2017. We performed multivariable logistic regression, comparing characteristics and outcomes among patients with TB reported to have diabetes and those whose diabetes status was unknown. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342266PMC

Increased plasma neurofilament light chain levels in patients with type-1 diabetes with impaired awareness of hypoglycemia.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Introduction: Impaired awareness of hypoglycemia (IAH) is a common complication in patients with type-1 diabetes (T1D). IAH is a major risk factor for severe hypoglycemic events, leading to adverse clinical consequences and cerebral damage. Non-invasive, cost-effective, and logistically efficient biomarkers for this condition have not been validated. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342474PMC

Efficacy and safety of patient-led versus physician-led titration of basal insulin in patients with uncontrolled type 2 diabetes: a meta-analysis of randomized controlled trials.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Scientific Direction, National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Italy.

Introduction: Insulin is the most effective antihyperglycemic treatment and basal insulin is the preferred initial formulation in patients with type 2 diabetes. However, its effects are dose-dependent, so adequate titration is necessary to reach targets. We performed a meta-analysis to compare the efficacy and safety of patient-led versus physician-led titration of basal insulin in patients with uncontrolled type 2 diabetes. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342431PMC

Occupational distribution of metabolic syndrome prevalence and incidence differs by sex and is not explained by age and health behavior: results from 75 000 Dutch workers from 40 occupational groups.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Department of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Introduction: This study examines the association between 40 occupational groups and prevalence and incidence of metabolic syndrome (MetS), separately for male and female workers, and whether age and health behaviors can explain the association.

Research Design And Methods: Data from 74 857 Lifelines Cohort and Biobank Study participants were used to regress occupational group membership, coded by Statistics Netherlands, on the prevalence and incidence of MetS using logistic and Cox regression analyses. MetS diagnosis was based on physical examinations, blood analysis, and recorded medication use. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342434PMC

Association of smoking cessation after new-onset type 2 diabetes with overall and cause-specific mortality among Korean men: a nationwide population-based cohort study.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Graduate School of Public Health, Yonsei University, Seoul, South Korea

Introduction: This study aimed to examine the association between smoking cessation after new-onset type 2 diabetes and overall and cause-specific mortality risks among Korean men.

Research Design And Methods: The Korean National Health Insurance Service-National Health Screening Cohort database was searched, and 13 377 Korean men aged ≥40 years diagnosed with new-onset type 2 diabetes between 2004 and 2007 were included and followed up until 2013. We defined smoking status changes by comparing participants' answers in the last survey before diagnosis to those in the first survey after diagnosis. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337624PMC

Drivers of weight loss in a CDC-recognized digital diabetes prevention program.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Livongo Health, Mountain View, California, USA.

Introduction: To investigate the impact of the digital Livongo Diabetes Prevention Program (DPP) on weight at 12 months, understand participants' self-monitoring behaviors associated with greater weight loss, and evaluate the impact of coaching interactions on more frequent self-monitoring behaviors.

Research Design And Methods: A retrospective analysis was performed using data from 2037 participants enrolled in the Livongo DPP who completed lesson 1 and recorded a starting weight during 2016-2017. Self-monitoring behaviors, including weigh-ins, food logging, activity, and coach-participant interactions, were analyzed at 6 and 12 months. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337618PMC

Metformin and statin use associate with plasma protein -glycosylation in people with type 2 diabetes.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

Introduction: Recent studies revealed -glycosylation signatures of type 2 diabetes, inflammation and cardiovascular risk factors. Most people with diabetes use medication to reduce cardiovascular risk. The association of these medications with the plasma -glycome is largely unknown. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333804PMC

Eleven-year multimorbidity burden among 637 255 people with and without type 2 diabetes: a population-based study using primary care and linked hospitalisation data.

BMJ Open 2020 Jul 1;10(7):e033866. Epub 2020 Jul 1.

Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester, UK.

Objectives: To compare the patterns of 18 physical and mental health comorbidities between people with recently diagnosed type 2 diabetes (T2D) and people without diabetes and how these change by age, gender and deprivation over time between 2004 and 2014. Also, to develop a metric to identify most prevalent comorbidities in people with T2D.

Design: Population-based cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033866DOI Listing

Effect of socioeconomic deprivation on outcomes of diabetes complications in patients with type 2 diabetes mellitus: a nationwide population-based cohort study of South Korea.

BMJ Open Diabetes Res Care 2020 Jul;8(1)

Department Preventive Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of)

Introduction: This study aimed to examine the effect of socioeconomic deprivation on the outcomes of diabetes complications in patients with type 2 diabetes mellitus (T2DM).

Research Design And Methods: We conducted a cohort study using claims data and 2005 national census data. We included of 7510 patients newly diagnosed with T2DM from 2004 to 2012 and aged 40 years or above. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-000729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332202PMC

Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Biochemistry, University of Hyderabad, Hyderabad, India

Introduction: Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). Previous studies have shown that AGEs contribute to glomerulosclerosis and proteinuria. Podocytes, terminally differentiated epithelial cells of the glomerulus and the critical component of the glomerular filtration barrier, express the receptor for AGEs (RAGE). Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326296PMC

Neighborhood walkability and pre-diabetes incidence in a multiethnic population.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

MAP-Centre for Urban Health Solutions, St Michael's Hospital, Toronto, Ontario, Canada.

Introduction: We examined whether adults living in highly walkable areas are less likely to develop pre-diabetes and if so, whether this association is consistent according to immigration status and ethnicity.

Research Design And Methods: Population-level health, immigration, and administrative databases were used to identify adults aged 20-64 (n=1 128 181) who had normoglycemia between January 2011 and December 2011 and lived in one of 15 cities in Southern Ontario, Canada. Individuals were assigned to one of ten deciles (D) of neighborhood walkability (from lowest (D1) to highest (D10)) and followed until December 2013 for the development of pre-diabetes. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-000908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326269PMC

Social factors associated with chronic non-communicable disease and comorbidity with mental health problems in India: a scoping review.

BMJ Open 2020 Jun 28;10(6):e035590. Epub 2020 Jun 28.

Department of Social Policy and Social Work, University of York, York, UK

Objectives: The purpose of this study is to examine the existing literature of the major social risk factors which are associated with diabetes, hypertension and the comorbid conditions of depression and anxiety in India.

Design: Scoping review.

Data Sources: Scopus, Embase, CINAHL Plus, PsycINFO, Web of Science and MEDLINE were searched for through September 2019. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322289PMC

Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA

Introduction: The hemochorial placenta provides a critical barrier at the maternal-fetal interface to modulate maternal immune tolerance and enable gas and nutrient exchange between mother and conceptus. Pregnancy outcomes are adversely affected by diabetes mellitus; however, the effects of poorly controlled diabetes on placental formation, and subsequently fetal development, are not fully understood.

Research Design And Methods: Streptozotocin was used to induce hyperglycemia in pregnant rats for the purpose of investigating the impact of poorly controlled diabetes on placental formation and fetal development. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322553PMC

Cardiovascular outcomes of type 2 diabetic patients treated with SGLT-2 inhibitors versus GLP-1 receptor agonists in real-life.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Medicine, Università degli Studi di Padova, Padova, Veneto, Italy

Introduction: Sodium glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) protect type 2 diabetic (T2D) patients from cardiovascular events, but no trial has directly compared their cardiovascular effects. We aimed to address this gap using real-world data.

Research Design And Methods: We performed a retrospective real-world study on a population of ~5 million inhabitants from North-East Italy. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319723PMC

Effectiveness of a comprehensive care protocol in patients with new diagnoses of type 2 diabetes mellitus and associated comorbidities in primary care: study protocol of a quasi-experimental trial.

BMJ Open 2020 Jun 23;10(6):e033725. Epub 2020 Jun 23.

Centre d'Atenció Primària Sanllehy, Gerència d'Àmbit d'Atenció Primària Barcelona Ciutat, Institut Català de la Salut, Barcelona, Spain.

Introduction: Type 2 diabetes mellitus (T2DM) is a highly prevalent chronic disease in the Spanish population. Typically, T2DM is associated with other chronic conditions. Intensive medication at the time of diagnosis has proven effective in reducing cardiovascular risk, improving glycaemic control and preventing T2DM complications. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312326PMC

Effect of treatment with exenatide and pioglitazone or basal-bolus insulin on diabetic neuropathy: a substudy of the Qatar Study.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Division of Cardiovascular Sciences, University of Manchester, Manchester, UK

Introduction: To assess the effect of exenatide and pioglitazone or basal-bolus insulin on diabetic peripheral neuropathy (DPN) in patients with poorly controlled type 2 diabetes (T2D).

Research Design And Methods: This is a substudy of the Qatar Study, an open-label, randomized controlled trial. 38 subjects with poorly controlled T2D were studied at baseline and 1-year follow-up and 18 control subjects were assessed at baseline only. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312325PMC

Adherence to ophthalmology referral, treatment and follow-up after diabetic retinopathy screening in the primary care setting.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Google, Mountain View, California, USA.

Introduction: Telemedicine-based diabetic retinopathy screening (DRS) in primary care settings has increased the screening rates of patients with diabetes. However, blindness from vision-threatening diabetic retinopathy (VTDR) is a persistent problem. This study examined the extent of patients' adherence to postscreening recommendations. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312438PMC

Disturbing medical findings in war-related traumatic amputation patients: a clinical descriptive study from Gaza.

BMJ Open 2020 Jun 22;10(6):e034648. Epub 2020 Jun 22.

The Anaesthesia and Critical Care Research Group, Institute of Clinical Medicine, The Arctic University of Norway, Tromsø, Norway.

Objectives: The aim of this study was to explore possible long-term negative health effects of injuries sustained by modern weaponry.

Setting: The study was conducted in Gaza's main hospital, Al-Shifa Hospital.

Participants: During the last 10 to 15 years, thousands of civilian Palestinians in Gaza have survived numerous military incursions, but with war-related traumatic injuries caused by explosive weapons. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311037PMC

Health impacts of seated arm ergometry training in patients with a diabetic foot ulcer: protocol for a randomised controlled trial.

BMJ Open 2020 Jun 21;10(6):e039062. Epub 2020 Jun 21.

Diabetes Research Centre, University of Leicester, Leicester, UK.

Introduction: Once diagnosed with a diabetic foot ulcer (DFU), patients are advised to offload, keeping pressure off the foot in order to facilitate ulcer healing. An increase in offloading is often accompanied by reductions in physical activity which can worsen the overall health of patients.While unable to perform traditional forms of upright activity, one mode of exercise that would allow patients to be physically active while adhering to offloading instruction is seated arm ergometry. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-039062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311002PMC

Risk of recurrent corneal erosion in patients with diabetes mellitus in Taiwan: a population-based cohort study.

BMJ Open 2020 Jun 21;10(6):e035933. Epub 2020 Jun 21.

Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan

Objective: To investigate the risk of recurrent corneal erosion (RCE) in patients with diabetes mellitus (DM).

Design, Setting And Participants: This retrospective, nationwide, matched cohort study included 239 854 patients with DM recruited between 2003 and 2005 from the Longitudinal Cohort of Diabetes Patients database. The control group included the same number of age-matched and sex-matched patients without DM selected from the Taiwan Longitudinal Health Insurance Database, 2000. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311018PMC
June 2020
2.063 Impact Factor

Validation of a type 1 diabetes algorithm using electronic medical records and administrative healthcare data to study the population incidence and prevalence of type 1 diabetes in Ontario, Canada.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

ICES, Toronto, Ontario, Canada.

Introduction: We aimed to develop algorithms distinguishing type 1 diabetes (T1D) from type 2 diabetes in adults ≥18 years old using primary care electronic medical record (EMRPC) and administrative healthcare data from Ontario, Canada, and to estimate T1D prevalence and incidence.

Research Design And Methods: The reference population was a random sample of patients with diabetes in EMRPC whose charts were manually abstracted (n=5402). Algorithms were developed using classification trees, random forests, and rule-based methods, using electronic medical record (EMR) data, administrative data, or both. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307536PMC

Long-term reversal of diabetes by subcutaneous transplantation of pancreatic islet cells and adipose-derived stem cell sheet using surface-immobilized heparin and engineered collagen scaffold.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Medical Science, Asan Medical Institute of Convergence Science and Technology (AMIST), Asan Medical Center, University of Ulsan College of Medicine, Seoul, The Republic of Korea

Objective: Esterified collagen (EC) can be functionalized with heparin to enhance islet graft stability. Growth factors secreted by human adipose-derived stem cells (hADSCs) can bind efficiently to EC-heparin (EC-Hep), which enhances revascularization and cell protection. We investigated the therapeutic potential of a combined heparin-esterified collagen-hADSC (HCA)-islet sheet to enhance islet engraftment. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307580PMC

Incidence and outcomes of hospitalization for community-acquired, ventilator-associated and non-ventilator hospital-acquired pneumonias in patients with type 2 diabetes mellitus in Spain.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, Spain.

Introduction: To describe the incidence and compare in-hospital outcomes of community-acquired pneumonia (CAP), ventilator-associated pneumonia (VAP) and non-ventilator hospital-acquired pneumonia (NV-HAP) among patients with or without type 2 diabetes mellitus (T2DM) using propensity score matching.

Research Design And Methods: This was a retrospective observational epidemiological study using the 2016-2017 Spanish Hospital Discharge Records.

Results: Of 245 221 admissions, CAP was identified in 227 524 (27. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304643PMC

Recurrent diabetic ketoacidosis and cognitive function among older adults with type 1 diabetes: findings from the Study of Longevity in Diabetes.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.

Introduction: Diabetic ketoacidosis (DKA) is a serious complication of diabetes. DKA is associated with poorer cognition in children with type 1 diabetes (T1D), but whether this is the case in older adults with T1D is unknown. Given the increasing life expectancy in T1D, understanding the role of DKA on brain health in older adults is crucial. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299028PMC

Study protocol for a nationwide Knowledge, Attitudes and Practices (KAP) survey on diabetes in Singapore's general population.

BMJ Open 2020 Jun 15;10(6):e037125. Epub 2020 Jun 15.

Research Division, Institute of Mental Health, 10 Buangkok View, Singapore.

Introduction: This study aims to establish the Knowledge, Attitudes and Practices (KAP) of the general population (people with and without diabetes) towards diabetes. The study will examine (a) recognition and understanding of causes, prevention and treatment strategies of diabetes; (b) identify the knowledge gaps and behavioural patterns that may hamper diabetes prevention and control; (c) stigma towards and stigma perceived by people with diabetes and (d) awareness of anti-diabetes campaigns.

Methods And Analysis: The study is a nationwide, cross-sectional study of Singapore's general population aged 18 years and above (n=3000), comprising Chinese, Malay, Indian and other ethnic groups, who can understand English, Chinese, Malay or Tamil language. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-037125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299045PMC
June 2020
2.063 Impact Factor

Key factors influencing the prescribing of statins: a qualitative study among physicians working in primary healthcare facilities in Indonesia.

BMJ Open 2020 Jun 15;10(6):e035098. Epub 2020 Jun 15.

PharmacoTherapy, -Epidemiology & -Economics, University of Groningen, Groningen, The Netherlands.

Objectives: To elicit key factors influencing physicians' decision to prescribe statins.

Design: A qualitative study using a phenomenological approach within a pragmatism interpretive framework. A combination of purposive and snowball sampling was used to recruit physicians. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299032PMC

DPP4i, thiazolidinediones, or insulin and risks of cancer in patients with type 2 diabetes mellitus on metformin-sulfonylurea dual therapy with inadequate control.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Family Medicine and Primary Care, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Introduction: This study aims to compare the risks of cancer among patients with type 2 diabetes mellitus (T2DM) on metformin-sulfonylurea dual therapy intensified with dipeptidyl peptidase 4 inhibitors (DPP4i), thiazolidinediones, or insulin.

Research Design And Methods: We assembled a retrospective cohort data of 20 577 patients who were free of cancer and on metformin-sulfonylurea dual therapy, and whose drug treatments were intensified with DPP4i (n=9957), insulin (n=7760), or thiazolidinediones (n=2860) from January 2006 to December 2017. Propensity-score weighting was used to balance out baseline covariates across the three groups. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295418PMC

Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) Study: design of lifestyle intervention.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Preventive Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Introduction: Intensive lifestyle intervention (ILI) prevents progression from prediabetes to type 2 diabetes (T2D) but reversal of prediabetes is less well studied.

Research Design And Methods: The overall objectives of the Pathobiology and Reversibility of Prediabetes in a Biracial Cohort (PROP-ABC) Study (ClinicalTrials.gov ID: NCT02027571) are to determine the natural history and reversibility of prediabetes. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-000899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292036PMC

Retinal arteriolar oxygen saturation predicts the need for intravitreal aflibercept in patients with diabetic macular oedema.

BMJ Open Ophthalmol 2020 27;5(1):e000382. Epub 2020 May 27.

Department of Ophthalmology, Odense University Hospital, Odense, Denmark.

Objective: Given the increasing burden of repetitive intravitreal injections in diabetic macular oedema (DMO) treatment, non-invasive markers of treatment outcome are needed. Hence, we aimed to examine retinal oximetry parameters as markers of need for intravitreal aflibercept in patients with DMO.

Methods: This study was based on data from a 12-month clinical trial including 35 eyes of 25 patients with centre involving DMO. Read More

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http://dx.doi.org/10.1136/bmjophth-2019-000382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259848PMC

Regional difference in the susceptibility of non-alcoholic fatty liver disease in China.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan Institute of Metabolic Disease, Fudan University, Shanghai, China

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a global health problem with high geographic heterogeneity. We aimed to investigate regional-specific concomitant rate of NAFLD and quantitative relationship between liver fat content (LFC) and glucose metabolism parameters in representative clinical populations from six provinces/municipalities of China.

Research Design And Methods: A total of 2420 eligible Han Chinese were enrolled consecutively from 10 clinics of obesity, diabetes and metabolic diseases located at six provinces/municipalities of China, and divided into North (Tianjin, Shandong and Heilongjiang) and South (Shanghai, Jiangsu and Henan) groups according to their geographical latitude and proximity of NAFLD concomitant rate. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287499PMC

Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan

Introduction: The present study aimed to evaluate the effects of flash glucose monitoring (FGM) and conventional self-monitoring of blood glucose (SMBG) on glycemic control in patients with non-insulin-treated type 2 diabetes.

Research Design And Methods: In this 24-week, multicenter, open-label, randomized (1:1), parallel-group study, patients with non-insulin-treated type 2 diabetes at five hospitals in Japan were randomly assigned to the FGM (n=49) or SMBG (n=51) groups and were provided each device for 12 weeks. The primary outcome was change in glycated hemoglobin (HbA1c) level, and was compared using analysis of covariance model that included baseline values and group as covariates. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292039PMC

Mapping the global evidence on nutrition transition: a scoping review protocol.

BMJ Open 2020 Jun 7;10(6):e034730. Epub 2020 Jun 7.

Senior Scientist Group Nutrition, Immunity and Metabolism, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Potsdam-Rehbrücke, Germany

Introduction: Nutrition transition has emerged as an important concept in health research used to describe shifts in dietary consumption and energy expenditure that coincide with economic, demographic and epidemiological changes at a population level. Better understanding of the shifts in dietary patterns across populations and their drivers could possibly hold the key to prevention of diet-related disease risk. An increasing number of studies have reported on nutrition transition in populations around the world, however, global evidence has not been summarised. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282322PMC

Telephone health coaching with exercise monitoring using wearable activity trackers (TeGeCoach) for improving walking impairment in peripheral artery disease: study protocol for a randomised controlled trial and economic evaluation.

BMJ Open 2020 Jun 4;10(6):e032146. Epub 2020 Jun 4.

Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany.

Introduction: Peripheral artery disease (PAD) is the third most prevalent cardiovascular disease worldwide, with smoking and diabetes being the strongest risk factors. The most prominent symptom is leg pain while walking, known as intermittent claudication. To improve mobility, first-line treatment for intermittent claudication is supervised exercise programmes, but these remain largely unavailable and economically impractical, which has led to the development of structured home-based exercise programmes. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-032146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279623PMC

Elevation of blood glucose level predicts worse outcomes in hospitalized patients with COVID-19: a retrospective cohort study.

BMJ Open Diabetes Res Care 2020 06;8(1)

Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

Introduction: With intense deficiency of medical resources during COVID-19 pandemic, risk stratification is of strategic importance. Blood glucose level is an important risk factor for the prognosis of infection and critically ill patients. We aimed to investigate the prognostic value of blood glucose level in patients with COVID-19. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298690PMC

Safety of medical compression stockings in patients with diabetes mellitus or peripheral arterial disease.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Vascular Surgery, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Bayern, Germany.

Introduction: Compression therapy is highly effective in the treatment of many venous diseases, including leg edema. However, its relevance in patients with peripheral arterial disease (PAD) or diabetes mellitus is critically discussed. The aim of the present study was to assess the influence of compression therapy on microperfusion and its safety in patients with PAD or diabetes mellitus. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279622PMC

Insulin pricing and other major diabetes-related concerns in the USA: a study of 46 407 tweets between 2017 and 2019.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Digital Epidemiology Hub, Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg

Introduction: Little research has been done to systematically evaluate concerns of people living with diabetes through social media, which has been a powerful tool for social change and to better understand perceptions around health-related issues. This study aims to identify key diabetes-related concerns in the USA and primary emotions associated with those concerns using information shared on Twitter.

Research Design And Methods: A total of 11. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282343PMC

Clinicopathological features of fast eGFR decliners among patients with diabetic nephropathy.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.

Introduction: The speed of declining kidney function differs among patients with diabetic nephropathy. This study was undertaken to clarify clinical and pathological features that affect the speed of declining kidney function in patients with diabetic nephropathy.

Research Design And Methods: This study was design as multicenter retrospective study. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282298PMC

Time-driven activity-based costing for patients with multiple chronic conditions: a mixed-method study to cost care in a multidisciplinary and integrated care delivery centre at a university-affiliated tertiary teaching hospital in Stockholm, Sweden.

BMJ Open 2020 Jun 3;10(6):e032573. Epub 2020 Jun 3.

Learning, Informatics, Management, and Ethics, Karolinska Institutet, Stockholm, Sweden.

Objective: This study can be applied to cost the complex non-standardised processes used to treat patients with multiple chronic conditions.

Design: A mixed-method approach to cost analysis, following a modified healthcare-specific version of the seven-step Time-Driven Activity-Based Costing (TDABC) approach.

Setting: A multidisciplinary integrated and person-centred care delivery centre at a university-affiliated tertiary teaching hospital in Stockholm, Sweden, designed to improve care coordination for patients with multiple chronic conditions, specifically diabetes, cardiovascular disease and kidney disease. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-032573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279642PMC

Health literacy and exercise interventions on clinical outcomes in Chinese patients with diabetes: a propensity score-matched comparison.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety (National Ministry of Education), Fudan University, Shanghai, China

Introduction: Patients with diabetes in China have low health literacy, which likely leads to poor clinical outcomes. This study aimed to assess the effectiveness of health literacy and exercise interventions on clinical measurements in Chinese adults with type 2 diabetes mellitus (T2DM).

Research Design And Methods: A cluster randomized controlled trial was conducted from February 2015 through April 2017 in Shanghai, China. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264995PMC

Efficacy and safety of flash glucose monitoring in patients with type 1 and type 2 diabetes: a systematic review and meta-analysis.

BMJ Open Diabetes Res Care 2020 Jun;8(1)

Department of Emergency and Organ Transplantation, University of Bari, Bari, Puglia, Italy

Introduction: Flash glucose monitoring (FGM) is a factory-calibrated sensor-based technology for the measurement of interstitial glucose. We performed a systematic review and meta-analysis to assess its efficacy and safety in patients with type 1 and type 2 diabetes.

Research Design And Methods: PubMed, CENTRAL, Scopus and Web of Science were searched in July 2019. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265013PMC

The silent epidemic of obesity in The Gambia: evidence from a nationwide, population-based, cross-sectional health examination survey.

BMJ Open 2020 Jun 1;10(6):e033882. Epub 2020 Jun 1.

Research Department of Epidemiology and Public Health, University College London, London, UK.

Objectives: Non-communicable diseases account for 70% of global deaths; 80% occur in low-income and middle-income countries. The rapid increase of obesity in sub-Saharan Africa is a concern. We assessed generalised and abdominal obesity and their associated risk factors among adults in The Gambia. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265034PMC

Correlation between markers of renal function and sight-threatening diabetic retinopathy in type 2 diabetes: a longitudinal study in an Indian clinic population.

BMJ Open Diabetes Res Care 2020 May;8(1)

Diabetology, Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu, India

Introduction: Previous epidemiological studies have reported on the prevalence of diabetic kidney disease (DKD) and diabetic retinopathy (DR) from India. The aim of this study is to evaluate the effect of DKD on the development of new-onset DR and sight-threatening diabetic retinopathy (STDR) in Asian Indians with type 2 diabetes (T2D).

Research Design And Methods: The study was done on anonymized electronic medical record data of people with T2D who had undergone screening for DR and renal work-up as part of routine follow-up at a tertiary care diabetes center in Chennai, South India. Read More

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http://dx.doi.org/10.1136/bmjdrc-2020-001325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265015PMC

Prevalence, incidence and mortality of type 1 and type 2 diabetes in Denmark 1996-2016.

BMJ Open Diabetes Res Care 2020 May;8(1)

Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Hovedstaden, Denmark

Introduction: The objective of this study was to give an overview of prevalence, incidence and mortality of type 1 (T1D) and type 2 diabetes (T2D) in Denmark, and their temporal trends.

Research Design And Methods: We constructed a diabetes register from existing population-based healthcare registers, including a classification of patients as T1D or T2D, with coverage from 1996 to 2016. Using complete population records for Denmark, we derived prevalence, incidence, mortality and standardized mortality ratio (SMR). Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265004PMC

Long-term changes in carbohydrate tolerance, insulin secretion and action in African-American patients with obesity and history of hyperglycemic crises.

BMJ Open Diabetes Res Care 2020 May;8(1)

Department of Medicine, Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia, USA.

Introduction: Many African-Americans (AA) with obesity with newly diagnosed diabetes presenting with diabetic ketoacidosis (DKA) or severe hyperglycemia (SH) discontinue insulin therapy and achieve near-normoglycemia remission (hemoglobin A1c (HbA1c) <7%, fasting blood glucose (FBG) <130 mg/dL) and able to be managed on oral antidiabetic agents (OAD) during follow-up. Using combined data from two randomized controlled trials, we assessed long-term carbohydrate tolerance and changes in insulin sensitivity and insulin secretion.

Research Design And Methods: Seventy-five participants with DKA (n=33) and SH (n=42) underwent 2-hour 75 g oral glucose tolerance test (OGTT) after insulin discontinuation and every 6 months until hyperglycemia relapse (FBG ≥130 mg/dL, HbA1c >7% or two random BG ≥180 mg/dL) while treated with OAD (metformin, sitagliptin or pioglitazone) or placebo. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265016PMC

'Turning the tide' on hyperglycemia in pregnancy: insights from multiscale dynamic simulation modeling.

BMJ Open Diabetes Res Care 2020 May;8(1)

Computational Epidemiology and Public Health Informatics Laboratory, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Introduction: Hyperglycemia in pregnancy (HIP, including gestational diabetes and pre-existing type 1 and type 2 diabetes) is increasing, with associated risks to the health of women and their babies. Strategies to manage and prevent this condition are contested. Dynamic simulation models (DSM) can test policy and program scenarios before implementation in the real world. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-000975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265040PMC

Improved diabetes control among low-income Mexican Americans through community-clinical interventions: results of an RCT.

BMJ Open Diabetes Res Care 2020 May;8(1)

Division of Clinical and Translational Sciences, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Introduction: This randomized controlled trial investigated community-clinical intervention strategies for a Mexican American population who had not demonstrated control of their diabetes. We tested a control program (Salud y Vida 1.0) supporting diabetes management versus an enhanced version (Salud y Vida 2. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-000867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264997PMC