1,190 results match your criteria BMJ open diabetes research & care[Journal]


Estimating the magnitude of diabetes mellitus and diabetic retinopathy in an older age urban population in Pune, western India.

BMJ Open Ophthalmol 2019 28;4(1):e000201. Epub 2019 Feb 28.

Department of Community Ophthalmology, PBMA's H. V. Desai Eye Hospital, Pune, Maharashtra, India.

Objective: To estimate magnitude of diabetes mellitus (DM) and diabetic retinopathy (DR) in a high risk population in Pune, western India.

Methods: DR module in rapid assessment of avoidable blindness (RAAB) survey methodology was used. Sample size of 3527 was calculated based on estimates from previous studies in India. Read More

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http://dx.doi.org/10.1136/bmjophth-2018-000201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440599PMC
February 2019

Diabetes in pregnancy in associations with perinatal and postneonatal mortality in First Nations and non-Indigenous populations in Quebec, Canada: population-based linked birth cohort study.

BMJ Open 2019 Apr 15;9(4):e025084. Epub 2019 Apr 15.

Obstetrics and Gynecology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Objective: Both pregestational and gestational diabetes mellitus (PGDM, GDM) occur more frequently in First Nations (North American Indians) pregnant women than their non-Indigenous counterparts in Canada. We assessed whether the impacts of PGDM and GDM on perinatal and postneonatal mortality may differ in First Nations versus non-Indigenous populations.

Design: A population-based linked birth cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025084DOI Listing

Patient-centred rehabilitation for non-communicable disease in a low-resource setting: study protocol for a feasibility and proof-of-concept randomised clinical trial.

BMJ Open 2019 Apr 11;9(4):e025732. Epub 2019 Apr 11.

Department of Physiotherapy, Stellenbosch University, Cape Town, South Africa.

Introduction: Non-communicable diseases (NCDs) are the leading cause of death globally. Even though NCD disproportionally affects low-to-middle income countries, these countries including South Africa, often have limited capacity for the prevention and control of NCDs. The standard evidence-based care for the long-term management of NCDs includes rehabilitation. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02573
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http://dx.doi.org/10.1136/bmjopen-2018-025732DOI Listing
April 2019
6 Reads

Telemedical coaching for weight loss in overweight employees: a three-armed randomised controlled trial.

BMJ Open 2019 Apr 11;9(4):e022242. Epub 2019 Apr 11.

Occupational Health and Medical Services, Boehringer Ingelheim Pharma GmbH & Co.KG, Ingelheim am Rhein, Germany.

Objectives: We examined the effect of a telemedical coaching (TMC) programme accompanied with or without telemonitoring on weight loss in an occupational healthcare setting with a three-armed randomised controlled trial (NCT01837134 'Pre-results').

Methods: Overweight employees (n=104, body mass index [BMI] ≥25 kg/m) were invited by their medical corporate department and randomised into either a TMC group (n=34) or in one of the two control groups (C1, n=34; C2, n=36). TMC and C1 were equipped with telemonitoring devices (scales and pedometers) at baseline, and C2 after 6 months. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022242DOI Listing

Impact of ischaemic heart disease severity and age on risk of cardiovascular outcome in diabetes patients in Sweden: a nationwide observational study.

BMJ Open 2019 Apr 3;9(4):e027199. Epub 2019 Apr 3.

Cardiology, Linkopings Universitet, Linkoping, Sweden.

Objectives: To compare short-term cardiovascular (CV) outcome in type 2 diabetes (T2D) patients without ischaemic heart disease (IHD), with IHD but no prior myocardial infarction (MI), and those with prior MI; and assess the impact on risk of age when initiating first-time glucose-lowering drug (GLD).

Design: Cohort study linking morbidity, mortality and medication data from Swedish national registries.

Participants: First-time users of GLD during 2007-2016. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027199DOI Listing
April 2019
1 Read

I-ACT: Integrated study on effect of Activity on ComplicaTions in pregnancy: study protocol of a multiethnic prospective cohort study.

BMJ Open 2019 Apr 3;9(4):e025970. Epub 2019 Apr 3.

Family Medicine Service, KK Women's and Children's Hospital, Singapore, Singapore.

Introduction: Physical activity (PA) during first 20 weeks of pregnancy may lower risks of gestational diabetes mellitus (GDM) and gestational hypertension (GH), though evidence of association remains inconclusive. Current studies rely heavily on subjective assessment of PA levels. Wearable activity trackers provide a convenient and objective surrogate index for PA validated by evidence-based steps/day categorisation along a physical inactivity/activity continuum. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025970DOI Listing
April 2019
4 Reads

Assessing health impacts of home food gardens with Wind River Indian Reservation families: protocol for a randomised controlled trial.

BMJ Open 2019 Apr 3;9(4):e022731. Epub 2019 Apr 3.

School of Pharmacy, University of Wyoming, Laramie, Wyoming, USA.

Introduction: This community-based participatory research, will be the first full-scale randomised controlled trial we have identified that is designed to evaluate impacts of home gardening on family health. It is based on observational studies suggesting home food gardening has myriad health benefits, Wind River Indian Reservation (WRIR) families' interest in home gardening and the need to end Native American health disparities with empowering, appropriate and effective health interventions.

Methods And Analysis: A total of 100 Native American families in WRIR who have not gardened recently but want to garden will be randomly allocated (1:1) to intervention (receiving 2 years of support designing, installing and maintaining a home food garden of at least 80 square feet (approximately 7 square meters) or to delayed-intervention control (receiving same gardening support after 2 years of data collection). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022731DOI Listing
April 2019
1 Read

Abdominal aortic calcification, bone mineral density and fractures: a systematic review and meta-analysis protocol.

BMJ Open 2019 Apr 2;9(4):e026232. Epub 2019 Apr 2.

The University of Sydney, Centre for Kidney Research, School of Public Health, Sydney Medical School, Children's Hospital at Westmead, New South Wales, Australia.

Introduction: Abdominal aortic calcification (AAC) is associated with low bone mass and increased fracture risk. Two previous meta-analyses have investigated the association between AAC and fracture. However, these meta-analyses only identified articles until December 2016, undertook limited searches and did not explore potential sources of between-study heterogeneity. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026232DOI Listing
April 2019
1 Read

Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation.

BMJ 2019 04 3;365:l1226. Epub 2019 Apr 3.

Clinical Trials Research Centre, University of Liverpool, Liverpool, UK.

Objective: To compare the efficacy, safety, and cost utility of continuous subcutaneous insulin infusion (CSII) with multiple daily injection (MDI) regimens during the first year following diagnosis of type 1 diabetes in children and young people.

Design: Pragmatic, multicentre, open label, parallel group, randomised controlled trial and economic evaluation.

Setting: 15 paediatric National Health Service (NHS) diabetes services in England and Wales. Read More

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http://dx.doi.org/10.1136/bmj.l1226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446076PMC
April 2019
1 Read

Healthcare resource utilisation and cost associated with elevated potassium levels: a Danish population-based cohort study.

BMJ Open 2019 Apr 1;9(4):e026465. Epub 2019 Apr 1.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark.

Objectives: To investigate healthcare costs associated with hyperkalaemia (HK) among patients with chronic kidney disease (CKD), heart failure (HF) or diabetes.

Design: Before-after cohort study of patients with HK and matched patients without HK.

Setting: Population-based databases covering primary and secondary care for the entire of Northern Denmark. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026465DOI Listing
April 2019
4 Reads

The effect of luseogliflozin and alpha-glucosidase inhibitor on heart failure with preserved ejection fraction in diabetic patients: rationale and design of the MUSCAT-HF randomised controlled trial.

BMJ Open 2019 Mar 30;9(3):e026590. Epub 2019 Mar 30.

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Introduction: Type 2 diabetes mellitus (T2DM) is a strong risk factor for coronary artery disease and heart failure, particularly heart failure with preserved ejection fraction (HFpEF). The aim of the ongoing MUSCAT-HF (It stands for Prospective Comparison of Luseogliflozin and Alpha-glucosidase on the Management of Diabetic Patients with Chronic Heart Failure and Preserved Ejection Fraction) trial is to evaluate the efficacy of luseogliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, versus voglibose, an alpha-glucosidase inhibitor, using brain natriuretic peptide (BNP) as the index of therapeutic effect in T2DM patients with HFpEF.

Methods And Analysis: A total of 190 patients with T2DM and HFpEF (ejection fraction >45%) who are drug-naïve or taking any anti-diabetic agents will be randomised (1:1) to receive luseogliflozin 2. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026590DOI Listing
March 2019
3 Reads

Rationale, design and study protocol of the randomised controlled trial: Diabetes Interventional Assessment of Slimming or Training tO Lessen Inconspicuous Cardiovascular Dysfunction (the DIASTOLIC study).

BMJ Open 2019 Mar 30;9(3):e023207. Epub 2019 Mar 30.

Department of Cardiovascular Sciences, University of Leicester and the Leicester NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Introduction: Despite their young age and relatively short duration of disease, younger adults with type 2 diabetes (T2D) already have diastolic dysfunction and may be at risk of incipient heart failure. Whether weight loss or exercise training improve cardiac dysfunction in people with T2D remains to be established.

Methods And Analysis: Prospective, randomised, open-label, blind endpoint trial. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023207DOI Listing
March 2019
2 Reads

Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials.

BMJ Open 2019 Mar 30;9(3):e017995. Epub 2019 Mar 30.

Nutrition Department, Pitie-Salpêtrière hospital, Institute of Cardiometabolism and Nutrition, Assistance Publique-Hôpitaux de Paris, Paris, France.

Objective: To systematically review the effect of oral intake of bacterial probiotics on 15 variables related to obesity, diabetes and non-alcoholic fatty liver disease.

Design: Systematic review and meta-analysis.

Data Sources: Medline, EMBASE and COCHRANE from 1990 to June 2018. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-017995DOI Listing
March 2019
2 Reads

INSoles To Ease Pressure (INSTEP) Study: a multicentre, randomised controlled feasibility study to compare the effectiveness of a novel instant optimised insole with a standard insole for people with diabetic neuropathy: a study protocol.

BMJ Open 2019 Mar 23;9(3):e029185. Epub 2019 Mar 23.

School of Health Professions Faculty of Health and Human Sciences, University of Plymouth, Plymouth, UK.

Introduction: Foot ulceration is a multifactorial complication of diabetes. Therapeutic insoles and footwear are frequently used to reduce elevated tissue pressures associated with risk of foot ulceration. A novel protocol using in-shoe pressure measurement technology to provide an instant optimised insole and house shoe solution has been developed, with the aim of reducing foot ulceration. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-029185DOI Listing
March 2019
1 Read

'Managing scarcity'- a qualitative study on volunteer-based healthcare for chronically ill, uninsured migrants in Berlin, Germany.

BMJ Open 2019 Mar 23;9(3):e025018. Epub 2019 Mar 23.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of General Practice, Berlin, Germany.

Objectives: In Germany, healthcare for people lacking legal residency status and European Union citizens without health insurance is often provided by non-governmental organisations. Scientific studies assessing the situation of the patients with chronic diseases in this context are scarce. We aimed to characterise medical care for chronically ill migrants without health insurance and outline its possibilities and limitations from the treating physicians' perspective. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025018DOI Listing
March 2019
1 Read

Comparison of medical comorbidity between patients with primary angle-closure glaucoma and a control cohort: a population-based study from Taiwan.

BMJ Open 2019 Mar 23;9(3):e024209. Epub 2019 Mar 23.

Management Office for Health Data, China Medical University, Taichung, Taiwan.

Objective: To determine the prevalence and risk of systemic comorbidities in primary angle-closure glaucoma in Taiwan population.

Methods: We included 3322 primary angle-closure glaucoma (PACG) subjects and randomly selected patients without PACG from the Taiwan National Health Insurance Research Database and frequency matched four of them (n=13 288) to each PACG patient, based on age and sex. The univariable and multivariable unconditional logistic regression models were used to estimate the effect of comorbidities on the risk of PACG as indicated by the OR with 95% CI. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024209DOI Listing

Trends in the Use of Common Words and Patient-Centric Language in the Titles of Medical Journals, 1976-2015.

JAMA Netw Open 2019 Mar 1;2(3):e191083. Epub 2019 Mar 1.

Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Importance: The language of medical research appears to be intrinsically tied to the culture of medical research and provides a unique window into broader trends in the culture of medicine.

Objective: To analyze medical language from 5 premier medical journals and investigate broader changes in the culture of clinical investigation during the last 40 years.

Design, Setting, And Participants: In this qualitative study using a data-driven analysis, 302 293 PubMed records were extracted from JAMA, The Lancet, Annals of Internal Medicine, the BMJ, and New England Journal of Medicine from January 1, 1976, through December 31, 2015, to identify key trends in medical language. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.1083DOI Listing
March 2019
4 Reads

Incorporating patients' perspectives into the initial stages of core outcome set development: a rapid review of qualitative studies of type 2 diabetes.

BMJ Open Diabetes Res Care 2019 28;7(1):e000615. Epub 2019 Feb 28.

MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK.

Conducting systematic reviews of qualitative studies to incorporate patient perspectives within the early stages of core outcome set (COS) development can be resource intensive. We aimed to identify an expedited approach to be used as part of the wider COS development process. Specifically, we undertook a rapid review of qualitative studies of patients' views and experiences of type 2 diabetes. Read More

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http://dx.doi.org/10.1136/bmjdrc-2018-000615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398822PMC
February 2019

Selenium supplementation and insulin resistance in a randomized, clinical trial.

BMJ Open Diabetes Res Care 2019 7;7(1):e000613. Epub 2019 Feb 7.

Department of Medicine, Stony Brook University, New York City, New York, USA.

Objective: While controversial, observational and randomized clinical trial data implicate the micronutrient selenium (Se) in the development of type 2 diabetes (T2D). The aim of this study was to test the hypothesis that Se supplementation adversely affects pancreatic β-cell function and insulin sensitivity.

Research Design And Methods: In a subset of 400 individuals participating in a randomized, placebo-controlled trial of Se at 200 µg/day for colorectal adenomatous polyps, fasting plasma glucose and insulin were measured before randomization and within 6 months of completing intervention. Read More

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http://dx.doi.org/10.1136/bmjdrc-2018-000613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398811PMC
February 2019
3 Reads

Higher circulating adiponectin and lower orosomucoid were associated with postload glucose ≤70 mg/dL, a possible inverse marker for dysglycemia, in young Japanese women.

BMJ Open Diabetes Res Care 2019 7;7(1):e000596. Epub 2019 Feb 7.

Research Institute for Nutrition Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.

Objective: To examine whether serum adiponectin and orosomucoid were associated with postload glucose ≤70 mg/dL during an oral glucose tolerance test (OGTT), termed as postload low glycemia, a possible inverse marker for dysglycemia.

Research Design And Methods: 75 g OGTTs were performed with multiple postload glucose and insulin measurements over a 30-120 min period in 168 normal-weight Japanese women (18-24 years). Insulin resistance (IR) and β-cell function inferred from serum insulin kinetics during OGTT, fat mass and distribution by dual-energy X-ray absorptiometry (DXA), serum adiponectin and inflammatory markers were compared cross-sectionally between 39 women with and 129 women without postload low glycemia. Read More

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http://dx.doi.org/10.1136/bmjdrc-2018-000596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398809PMC
February 2019

Immune checkpoint inhibitors: an emerging cause of insulin-dependent diabetes.

BMJ Open Diabetes Res Care 2019 13;7(1):e000591. Epub 2019 Feb 13.

Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Objective: Insulin-dependent diabetes can occur with immune checkpoint inhibitor (ICI) therapy. We aimed to characterize the frequency, natural history and potential predictors of ICI-induced diabetes.

Research Design And Methods: We reviewed 1444 patients treated with ICIs over 6 years at our cancer center, and from the 1163 patients who received programmed cell death protein 1 (PD-1) inhibitors, we identified 21 such cases, 12 of which developed new-onset insulin-dependent diabetes and 9 experienced worsening of pre-existing type 2 diabetes. Read More

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http://dx.doi.org/10.1136/bmjdrc-2018-000591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398813PMC
February 2019
7 Reads

Plant-derived polyunsaturated fatty acids and markers of glucose metabolism and insulin resistance: a meta-analysis of randomized controlled feeding trials.

BMJ Open Diabetes Res Care 2019 8;7(1):e000585. Epub 2019 Feb 8.

Future Health and Wellness, Unilever Research and Development, Vlaardingen, The Netherlands.

The objective of this meta-analysis was to investigate the effects of plant-derived polyunsaturated fatty acids (PUFAs) on glucose metabolism and insulin resistance. Scopus and PubMed databases were searched until January 2018. Eligible studies were randomized controlled feeding trials that investigated the effects of a diet high in plant-derived PUFA as compared with saturated fatty acids (SFA) or carbohydrates and measured markers of glucose metabolism and insulin resistance as outcomes. Read More

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http://dx.doi.org/10.1136/bmjdrc-2018-000585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398820PMC
February 2019

Validity of ICD-10-CM codes for determination of diabetes type for persons with youth-onset type 1 and type 2 diabetes.

BMJ Open Diabetes Res Care 2019 16;7(1):e000547. Epub 2019 Feb 16.

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.

Objective: Diagnosis codes might be used for diabetes surveillance if they accurately distinguish diabetes type. We assessed the validity of (ICD-10-CM) codes to discriminate between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) among health plan members with youth-onset (diagnosis age <20 years) diabetes.

Research Design And Methods: Diabetes case identification and abstraction of diabetes type was done as part of the SEARCH for Diabetes in Youth Study. Read More

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http://dx.doi.org/10.1136/bmjdrc-2018-000547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398816PMC
February 2019
3 Reads

Self-reported hearing loss in Russians: the population-based Ural Eye and Medical Study.

BMJ Open 2019 Mar 20;9(3):e024644. Epub 2019 Mar 20.

Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.

Objective: With data on frequency of hearing loss in Russia and Eastern Europe generally lacking, we assessed the prevalence of hearing loss in a Russian population.

Setting: The population-based Ural Eye and Medical Study was conducted in the rural and urban regions of Bashkortostan, Russia.

Participants: With an inclusion criterion of age 40+ years, the study included 5899 (80. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024644DOI Listing
March 2019
3 Reads

Experiences of community-dwelling older adults living with multiple chronic conditions: a qualitative study.

BMJ Open 2019 Mar 20;9(3):e023345. Epub 2019 Mar 20.

School of Nursing, Aging, Community and Health Research Unit, McMaster University, Hamilton, Ontario, Canada.

Objectives: The aim of the study was to understand the experiences of living with multiple chronic conditions (MCC) from the perspective of community-living older adults with MCC.

Design: A qualitative study using an interpretive description approach.

Setting: Participants were recruited from southern Ontario, Canada. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02334
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http://dx.doi.org/10.1136/bmjopen-2018-023345DOI Listing
March 2019
3 Reads

Association between socioeconomic status and prevalence of non-communicable diseases risk factors and comorbidities in Bangladesh: findings from a nationwide cross-sectional survey.

BMJ Open 2019 Mar 13;9(3):e025538. Epub 2019 Mar 13.

Institute for Social Science Research, The University of Queensland, Queensland, Australia.

Objectives: This study aimed to examine the prevalence and distribution in the comorbidity of non-communicable diseases (NCDs) among the adult population in Bangladesh by measures of socioeconomic status (SES).

Design: This was a cross-sectional study.

Setting: This study used Bangladesh Demographic and Health Survey 2011 data. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429850PMC
March 2019
2.063 Impact Factor

'Next Generation Youth Well-being Study:' understanding the health and social well-being trajectories of Australian Aboriginal adolescents aged 10-24 years: study protocol.

BMJ Open 2019 Mar 12;9(3):e028734. Epub 2019 Mar 12.

Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.

Introduction: Australian Aboriginal and/or Torres Strait Islander (hereafter referred to as 'Aboriginal') adolescents (10-24 years) experience multiple challenges to their health and well-being. However, limited evidence is available on factors influencing their health trajectories. Given the needs of this group, the young age profile of the Aboriginal population and the long-term implications of issues during adolescence, reliable longitudinal data are needed. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429910PMC
March 2019
1 Read

Association between access to social service resources and cardiometabolic risk factors: a machine learning and multilevel modeling analysis.

BMJ Open 2019 Mar 12;9(3):e025281. Epub 2019 Mar 12.

Division of General Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Objectives: Interest in linking patients with unmet social needs to area-level resources, such as food pantries and employment centres in one's ZIP code, is growing. However, whether the presence of these resources is associated with better health outcomes is unclear. We sought to determine if area-level resources, defined as organisations that assist individuals with meeting health-related social needs, are associated with lower levels of cardiometabolic risk factors. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429845PMC
March 2019
1 Read

Relationship between serum osteocalcin/undercarboxylated osteocalcin and type 2 diabetes: a systematic review/meta-analysis study protocol.

BMJ Open 2019 Mar 12;9(3):e023918. Epub 2019 Mar 12.

Centre for Kidney Research, Children's Hospital, Westmead, New South Wales, Australia.

Introduction: The global burden of type 2 diabetes (T2DM) is steadily increasing. Experimental studies have demonstrated that a novel hormone secreted by bone cells, osteocalcin (OC), can stimulate beta-cell proliferation and improve insulin sensitivity in mice. Observational studies in humans have investigated the relationship between OC and metabolic parameters, and T2DM. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429918PMC

Prevalence of and risk factors for chronic kidney disease of unknown aetiology in India: secondary data analysis of three population-based cross-sectional studies.

BMJ Open 2019 Mar 7;9(3):e023353. Epub 2019 Mar 7.

Public Health Foundation of India, Gurgaon, Haryana, India.

Objectives: To assess whether chronic kidney disease of unknown aetiology (CKDu) is present in India and to identify risk factors for it using population-based data and standardised methods.

Design: Secondary data analysis of three population-based cross-sectional studies conducted between 2010 and 2014.

Setting: Urban and rural areas of Northern India (states of Delhi and Haryana) and Southern India (states of Tamil Nadu and Andhra Pradesh). Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02335
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-023353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429742PMC
March 2019
8 Reads

Use of metabolomics for predicting spontaneous preterm birth in asymptomatic pregnant women: protocol for a systematic review and meta-analysis.

BMJ Open 2019 Mar 4;9(3):e026033. Epub 2019 Mar 4.

Obstetrics and Gynecology, University of Campinas, Campinas, Brazil.

Introduction: Preterm birth (PTB) is the leading cause of neonatal mortality and short- and long-term morbidity. The aetiology and pathophysiology of spontaneous PTB (sPTB) are still unclear, which makes the identification of reliable and accurate predictor markers more difficult, particularly for unscreened or asymptomatic women. Metabolomics biomarkers have been demonstrated to be potentially accurate biomarkers for many disorders with complex mechanisms such as PTB. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429842PMC
March 2019
1 Read

Multimorbidity of cardiometabolic diseases: prevalence and risk for mortality from one million Chinese adults in a longitudinal cohort study.

BMJ Open 2019 Mar 3;9(3):e024476. Epub 2019 Mar 3.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Objectives: The evolution of multimorbidity describes the continuum from a healthy status to the development of a single disease and further progression to multimorbidity with additional diseases. We investigated the evolution of cardiometabolic multimorbidity and risk for mortality in a Chinese population.

Design: Longitudinal cohort study using data from the CHinese Electronic health Records Research in Yinzhou (CHERRY) study, with 5. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443196PMC

A Retrospective cohort study on the risk factors of deep vein thrombosis (DVT) for patients with traumatic fracture at Honghui Hospital.

BMJ Open 2019 Mar 3;9(3):e024247. Epub 2019 Mar 3.

Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, China.

Objective: To explore the risk factors of perioperative deep vein thrombosis (DVT) in patients with traumatic fracture after orthopaedic surgery and their potential diagnostic values in clinical.

Design: Retrospective cohort study.

Setting: Clinical Laboratory of Honghui Hospital, Xi'an JiaoTong University College of Medicine, Xi'an, Shaanxi, China. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443064PMC
March 2019
2 Reads
2.063 Impact Factor

Impact of Obesity on Postoperative Outcomes following cardiac Surgery (The OPOS study): rationale and design of an investigator-initiated prospective study.

BMJ Open 2019 Mar 3;9(3):e023418. Epub 2019 Mar 3.

Cardiovascular Research New Brunswick, and Department of Cardiac Surgery, Saint John Regional Hospital, Saint John, New Brunswick, Canada.

Introduction: Increasing levels of obesity worldwide have led to a rise in the prevalence of obesity-related complications including cardiovascular risk factors such as diabetes, hypertension and dyslipidaemia. Healthcare providers believe that overweight and obese cardiac surgery patients are more likely to experience adverse postoperative outcomes. The body mass index (BMI) is the primary measure of obesity in clinical practice, without accounting for a patient's level of cardiopulmonary fitness or muscle mass. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443054PMC
March 2019
3 Reads
2.063 Impact Factor

Global prevalence of diabetic retinopathy: protocol for a systematic review and meta-analysis.

BMJ Open 2019 Mar 3;9(3):e022188. Epub 2019 Mar 3.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Introduction: With increasing diabetes trends worldwide, morbidity, mortality and associated costs due to diabetes-related complications are a global public health concern. Diabetic retinopathy (DR) is among the leading causes of vision loss at the global level; accurate estimates of DR burden is of crucial importance for planning, implementing and evaluating DR prevention and care interventions.The available evidence on DR prevalence at the global level, dating back to 2008, only considered data from selected regions. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443069PMC
March 2019
7 Reads

Healthy Eating and Active Lifestyles for Diabetes (HEAL-D): study protocol for the design and feasibility trial, with process evaluation, of a culturally tailored diabetes self-management programme for African-Caribbean communities.

BMJ Open 2019 Mar 1;9(2):e023733. Epub 2019 Mar 1.

Diabetes & Nutritional Sciences Division, King's College London, London, UK.

Introduction: Black British communities are disproportionately burdened by type 2 diabetes (T2D) and its complications. Tackling these inequalities is a priority for healthcare providers and patients. Culturally tailored diabetes education provides long-term benefits superior to standard care, but to date, such programmes have only been developed in the USA. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398623PMC
March 2019
1 Read

Treatment patterns, persistence and adherence rates in patients with type 2 diabetes mellitus in Japan: a claims-based cohort study.

BMJ Open 2019 Mar 1;9(3):e025806. Epub 2019 Mar 1.

Japan Medical Affairs, Takeda Pharmaceutical Company Limited, Tokyo, Japan.

Objective: To determine real-world trends in antidiabetic drug use, and persistence and adherence, in Japanese patients with type 2 diabetes mellitus (T2DM).

Design: Retrospective evaluation of administrative claims data (2011-2015) using the Japan Medical Data Center (JMDC) and Medical Data Vision (MDV) databases.

Setting: Analysis of two administrative claims databases for Japanese patients with T2DM. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429930PMC
March 2019
10 Reads

Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study.

BMJ Open 2019 Mar 1;9(3):e025453. Epub 2019 Mar 1.

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Objectives: To estimate the current prevalence of cardiovascular disease risk factors (CRFs) and renal disorders across serum uric acid (SUA) quartiles, and evaluate the relationships between SUA and CRFs and renal diseases in Shanghai population.

Study Design: Observational, cross-sectional study.

Setting: Data were obtained from the physical check-up of local residents at three hospitals in Shanghai. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429858PMC
March 2019
5 Reads

Undisclosed financial ties between guideline writers and pharmaceutical companies: a cross-sectional study across 10 disease categories.

BMJ Open 2019 Feb 5;9(2):e025864. Epub 2019 Feb 5.

Charles Perkins Centre and Faculty of Pharmacy, University of Sydney, Sydney, Australia.

Objectives: To investigate the proportion of potentially relevant undisclosed financial ties between clinical practice guideline writers and pharmaceutical companies.

Design: Cross-sectional study of a stratified random sample of Australian guidelines and writers.

Setting: Guidelines available from Australia's National Health and Medical Research Council guideline database, 2012-2014, stratified across 10 health priority areas. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377504PMC
February 2019
2 Reads

Public perceptions of changing the terminology for low-risk thyroid cancer: a qualitative focus group study.

BMJ Open 2019 Feb 5;9(2):e025820. Epub 2019 Feb 5.

Wiser Healthcare, School of Public Health, University of Sydney, Sydney, New South Wales, Australia.

Objectives: To investigate public perceptions of overdiagnosis and overtreatment in low-risk thyroid cancer and explore opinions regarding the proposed strategy to change the terminology of low-risk cancers.

Design: Qualitative study using focus groups that included a guided group discussion and presentation explaining thyroid cancer, overdiagnosis and overtreatment, and proposed communication strategies. Transcripts were analysed thematically. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377531PMC
February 2019
3 Reads

Patterns of objectively assessed sedentary time and physical activity among Japanese workers: a cross-sectional observational study.

BMJ Open 2019 Feb 24;9(2):e021690. Epub 2019 Feb 24.

Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan.

Objectives: To examine patterns of sedentary behaviour and physical activity, among Japanese workers with differing occupational activity types.

Design: A cross-sectional observational study in 2013-2015.

Setting: Two local communities in Japan. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-021690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443067PMC
February 2019

Systematic scoping review of frameworks used to develop rehabilitation interventions for older adults.

BMJ Open 2019 Feb 22;9(2):e024185. Epub 2019 Feb 22.

Division of Rehabilitation and Ageing, University of Nottingham School of Medicine, Nottingham, UK.

Objectives: Rehabilitation interventions for older adults are complex as they involve a number of interacting components, have multiple outcomes of interest and are influenced by a number of contextual factors. The importance of rigorous intervention development prior to formal evaluation has been acknowledged and a number of frameworks have been developed. This review explored which frameworks have been used to guide the development of rehabilitation interventions for older adults. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02418
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http://dx.doi.org/10.1136/bmjopen-2018-024185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398678PMC
February 2019
8 Reads

Diabetes Prevalence Survey of Pakistan (DPS-PAK): prevalence of type 2 diabetes mellitus and prediabetes using HbA1c: a population-based survey from Pakistan.

BMJ Open 2019 Feb 21;9(2):e025300. Epub 2019 Feb 21.

The School of Medicine and Manchester Academic Sciences Centre, University of Manchester, Manchester, UK.

Objectives: We conducted a Pakistan-wide community-based survey on the prevalence of type 2 diabetes using glycated haemoglobin (HbA1c) as the screening test. The aim was to estimate diabetes prevalence across different demographic groups as well as all regions of Pakistan.

Design, Settings And Participants: Multistaged stratified cluster sampling was used for the representative selection of people aged ≥20 years, residing in 378 sampled clusters of 16 randomly selected districts, in this cross-sectional study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398762PMC
February 2019
6 Reads
2.063 Impact Factor

Incidence and relative risk for developing cancers in women with gestational diabetes mellitus: a nationwide cohort study in Taiwan.

BMJ Open 2019 Feb 21;9(2):e024583. Epub 2019 Feb 21.

College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.

Objectives: To evaluate the risk of developing cancers, particularly site-specific cancers, in women with gestational diabetes mellitus (GDM) in Taiwan.

Setting: The National Health Insurance Research Database (NHIRD) of Taiwan.

Participants: This study was conducted using the nationwide data from 2000 to 2013. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02458
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-024583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398720PMC
February 2019
5 Reads

Kanagawa Investigation of the Total Check-up Data from the National database (KITCHEN): protocol for data-driven population-based repeated cross-sectional and 6-year cohort studies.

BMJ Open 2019 Feb 21;9(2):e023323. Epub 2019 Feb 21.

School of Nutrition and Dietetics, Faculty of Health and Social Services, Kanagawa University of Human Services, Yokosuka, Japan.

Introduction: The unmitigated incidence of cardiometabolic diseases, such as type 2 diabetes and metabolic syndrome, has gained attention in Japan. 'Big data' can be useful to clarify conflicting observations obtained from studies with small samples and about rare conditions that are often neglected. We epidemiologically address these issues using data from health check-ups conducted in Kanagawa Prefecture, the prefecture with the second largest population in Japan, in the Kanagawa Investigation of the Total Check-up Data from the National Database (KITCHEN). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398776PMC
February 2019
2 Reads

How do participant experiences and characteristics influence engagement in exercise referral? A qualitative longitudinal study of a scheme in Northumberland, UK.

BMJ Open 2019 Feb 20;9(2):e024370. Epub 2019 Feb 20.

Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

Objectives: Exercise referral schemes (ERSs) are internationally widespread. This study aimed to gain an insight into differential engagement through understanding participant experiences of patients referred by healthcare professionals to one such scheme in the UK.

Design: The study employed a qualitative longitudinal approach using semistructured interviews, with results reported using Consolidated criteria for Reporting Qualitative research guidelines. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398729PMC
February 2019

Effect of text messaging on depression in patients with coronary heart disease: a substudy analysis from the TEXT ME randomised controlled trial.

BMJ Open 2019 Feb 20;9(2):e022637. Epub 2019 Feb 20.

The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Objective: We aimed to evaluate the effects on depression scores of a lifestyle-focused cardiac support programme delivered via mobile phone text messaging among patients with coronary heart disease (CHD).

Design: Substudy and secondary analysis of a parallel-group, single-blind randomised controlled trial of patients with CHD.

Setting: A tertiary hospital in Sydney, Australia. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398727PMC
February 2019
2 Reads
2.063 Impact Factor

Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study.

BMJ Open 2019 Feb 19;9(2):e027004. Epub 2019 Feb 19.

Genomic and Genetic Diagnosis Unit, Research Foundation of Valencia University Clinical Hospital-INCLIVA, Valencia, Spain.

Objective: To study the association of genes involved in the mitochondrial respiratory chain (MRC) pathway with body mass index (BMI) and obesity risk.

Design: This work studies three cross-sectional populations from Spain, representing three provinces: HORTEGA (Valladolid, Northwest/Centre), SEGOVIA (Segovia, Northwest/centre) and PIZARRA (Malaga,South).

Setting: Forty-eight single nucleotide polymorphisms (SNPs) from MRC genes were selected and genotyped by SNPlex method. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377525PMC
February 2019
4 Reads

Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy.

BMJ Open 2019 Feb 19;9(2):e025939. Epub 2019 Feb 19.

Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.

Purpose: A prospective cohort study for pregnant women, the Maternity Log study, was designed to construct a time-course high-resolution reference catalogue of bioinformatic data in pregnancy and explore the associations between genomic and environmental factors and the onset of pregnancy complications, such as hypertensive disorders of pregnancy, gestational diabetes mellitus and preterm labour, using continuous lifestyle monitoring combined with multiomics data on the genome, transcriptome, proteome, metabolome and microbiome.

Participants: Pregnant women were recruited at the timing of first routine antenatal visits at Tohoku University Hospital, Sendai, Japan, between September 2015 and November 2016. Of the eligible women who were invited, 65. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398744PMC
February 2019
1 Read

Identification of barriers, facilitators and system-based implementation strategies to increase teleophthalmology use for diabetic eye screening in a rural US primary care clinic: a qualitative study.

BMJ Open 2019 Feb 18;9(2):e022594. Epub 2019 Feb 18.

Health Innovation Program, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.

Objective: Teleophthalmology for diabetic eye screening is an evidence-based intervention substantially underused in US multipayer primary care clinics, even when equipment and trained personnel are readily available. We sought to identify patient and primary care provider (PCP) barriers, facilitators, as well as strategies to increase teleophthalmology use.

Design: We conducted standardised open-ended, individual interviews and analysed the transcripts using both inductive and directed content analysis to identify barriers and facilitators to teleophthalmology use. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02259
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-022594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398662PMC
February 2019
4 Reads