11,645 results match your criteria BMJ open[Journal]


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BMJ Open 2018 Dec 16;8(12):e022947corr1. Epub 2018 Dec 16.

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http://dx.doi.org/10.1136/bmjopen-2018-022947corr1DOI Listing
December 2018

Poststroke depression and risk of stroke recurrence and mortality: protocol of a meta-analysis and systematic review.

BMJ Open 2018 Dec 16;8(12):e026316. Epub 2018 Dec 16.

Institute of Acupuncture and Anesthesia, Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Introduction: A number of observational studies have indicated that poststroke depression could increase the risk of stroke outcomes. There is a meta-analysis indicating that poststroke depression is a risk factor of all-cause mortality. This paper reports the protocol for a systematic review and meta-analysis to clarify the associations of poststroke depression with stroke recurrence and mortality in order to determine whether poststroke depression is a predictor of stroke outcomes according to data extracted from relevant observational studies. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026316DOI Listing
December 2018

Interventions targeted at health professionals to reduce unnecessary caesarean sections: a qualitative evidence synthesis.

BMJ Open 2018 Dec 16;8(12):e025073. Epub 2018 Dec 16.

Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.

Objective: To establish the views and experiences of healthcare professionals in relation to interventions targeted at them to reduce unnecessary caesareans.

Design: Qualitative evidence synthesis.

Setting: Studies undertaken in high-income, middle-income and low-income settings. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025073DOI Listing
December 2018

Precision-Exercise-Prescription in patients with lung cancer undergoing surgery: rationale and design of the PEP study trial.

BMJ Open 2018 Dec 16;8(12):e024672. Epub 2018 Dec 16.

Department of Surgery, University of Utah, Salt Lake City, Utah, USA.

Introduction: Lung cancer is a significant burden on societies worldwide, and the most common cause of death in patients with cancer overall. Exercise intervention studies in patients with lung cancer have consistently shown benefits with respect to physical and emotional functioning. However, to date, exercise training has not been consistently implemented into clinical practice given that interventions have been costly and not aligned with clinical care. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024672DOI Listing
December 2018

Exploring patient-reported outcomes of home-based cardiac rehabilitation in relation to Scottish, UK and European guidelines: an audit using qualitative methods.

BMJ Open 2018 Dec 16;8(12):e024499. Epub 2018 Dec 16.

The Heart Manual Department, NHS Lothian, Edinburgh, UK.

Objectives: The Heart Manual (HM) is the UK's leading facilitated home-based cardiac rehabilitation (CR) programme for individuals recovering from myocardial infarction and revascularisation. This audit explored patient-reported outcomes of home-based CR in relation to current Scottish, UK and European guidelines.

Setting: Patients across the UK returned their questionnaire after completing the HM programme to the HM Department (NHS Lothian). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024499DOI Listing
December 2018

Systematic review and meta-analysis of prognostic factors for idiopathic inflammatory myopathy-associated interstitial lung disease.

BMJ Open 2018 Dec 16;8(12):e023998. Epub 2018 Dec 16.

Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan.

Objective: To clarify prognostic factors for idiopathic inflammatory myopathy (IIM)-associated interstitial lung disease (ILD).

Design: Systematic review and meta-analysis using the Grades of Recommendation, Assessment, Development and Evaluation system.

Data Sources: Medline, EMBASE and Science Citation Index Expanded were searched through 9 August 2018. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023998DOI Listing
December 2018

Early weight gain after stopping smoking: a predictor of overall large weight gain? A single-site retrospective cohort study.

BMJ Open 2018 Dec 16;8(12):e023987. Epub 2018 Dec 16.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Objectives: Most people gain weight on stopping smoking but the extent of weight gain varies greatly. Interventions aimed at all quitters to prevent weight gain on cessation have proven unpopular but targeting people who have gained excess weight immediately after quitting may improve uptake and cost-effectiveness. We examined whether early large postcessation weight gain predicts overall large weight gain. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023987DOI Listing
December 2018

Scoping review of priority setting of research topics for musculoskeletal conditions.

BMJ Open 2018 Dec 16;8(12):e023962. Epub 2018 Dec 16.

Monash Department of Clinical Epidemiology, Cabrini Institute, Malvern, Victoria, Australia.

Objective: Describe research methods used in priority-setting exercises for musculoskeletal conditions and synthesise the priorities identified.

Design: Scoping review.

Setting And Population: Studies that elicited the research priorities of patients/consumers, clinicians, researchers, policy-makers and/or funders for any musculoskeletal condition were included. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023962DOI Listing
December 2018

The personal and social experiences of community-dwelling younger adults after stroke in Australia: a qualitative interview study.

BMJ Open 2018 Dec 16;8(12):e023525. Epub 2018 Dec 16.

Stroke Division, Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.

Objectives: To examine the personal and social experiences of younger adults after stroke.

Design: Qualitative study design involving in-depth semi-structured interviews and rigorous qualitative descriptive analysis informed by social constructionism.

Participants: Nineteen younger stroke survivors aged 18 to 55 years at the time of their first-ever stroke. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023525DOI Listing
December 2018

In-hospital dementia-related deaths following implementation of the national dementia plan: observational study of national death certificates from 1996 to 2016.

BMJ Open 2018 Dec 16;8(12):e023172. Epub 2018 Dec 16.

Mental Health Promotion Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Objective: To examine changes in places of dementia-related death following implementation of the national dementia plan and other policy initiatives.

Design: Observational study.

Setting: Japan between October 1996 and September 2016. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023172DOI Listing
December 2018

Improving the quality of administration of the Surgical Safety Checklist: a mixed methods study in New Zealand hospitals.

BMJ Open 2018 Dec 16;8(12):e022882. Epub 2018 Dec 16.

Department of Anesthesia and Perioperative Medicine, Auckland City Hospital, Auckland, New Zealand.

While the WHO Surgical Safety Checklist (the Checklist) can improve patient outcomes, variable administration can erode benefits. We sought to understand and improve how operating room (OR) staff use the Checklist. Our specific aims were to: determine if OR staff can discriminate between good and poor quality of Checklist administration using a validated audit tool (WHOBARS); to determine reliability and accuracy of WHOBARS self-ratings; determine the influence of demographic variables on ratings and explore OR staff attitudes to Checklist administration. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022882DOI Listing
December 2018

Born to be Wise: a population registry data linkage protocol to assess the impact of modifiable early-life environmental exposures on the health and development of children.

BMJ Open 2018 Dec 14;8(12):e026954. Epub 2018 Dec 14.

Fielding School of Public Health, University of California, Los Angeles, California, USA.

Introduction: Deficiencies in childhood development is a major global issue and inequalities are large. The influence of environmental exposures on childhood development is currently insufficiently explored. This project will analyse the impact of various modifiable early life environmental exposures on different dimensions of childhood development. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026954DOI Listing
December 2018
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Effectiveness of cognitive-behavioural therapy: a protocol for an overview of systematic reviews and meta-analyses.

BMJ Open 2018 Dec 14;8(12):e025761. Epub 2018 Dec 14.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Introduction: Cognitive-behavioural therapy (CBT) is a psychological therapy that has been used to improve patient well-being across multiple mental and physical health problems. Its effectiveness has been examined in thousands of randomised control trials that have been synthesised into hundreds of systematic reviews. The aim of this overview is to map, synthesise and assess the reliability of evidence generated from these systematic reviews of the effectiveness of CBT across all health conditions, patient groups and settings. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025761DOI Listing
December 2018
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Dexamethasone versus prednisone for children receiving asthma treatment in the paediatric inpatient population: protocol for a feasibility randomised controlled trial.

BMJ Open 2018 Dec 14;8(12):e025630. Epub 2018 Dec 14.

Departments of Pediatrics and Emergency Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada.

Introduction: Asthma exacerbations are a leading cause of paediatric hospitalisations. Corticosteroids are key in the treatment of asthma exacerbations. Most current corticosteroids treatment regimens for children admitted with asthma exacerbation consist of a 5-day course of prednisone or prednisolone. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025630DOI Listing
December 2018

Understanding cauda equina syndrome: protocol for a UK multicentre prospective observational cohort study.

BMJ Open 2018 Dec 14;8(12):e025230. Epub 2018 Dec 14.

Department for Clinical Neurosciences, Western General Hospital, Edinburgh, UK.

Introduction: Cauda equina syndrome (CES) is a potentially devastating condition caused by compression of the cauda equina nerve roots. This can result in bowel, bladder and sexual dysfunction plus lower limb weakness, numbness and pain. CES occurs infrequently, but has serious potential morbidity and medicolegal consequences. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025230DOI Listing
December 2018

Role of diffusional kurtosis imaging in grading of brain gliomas: a protocol for systematic review and meta-analysis.

BMJ Open 2018 Dec 14;8(12):e025123. Epub 2018 Dec 14.

Lysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery UCL Hospitals NHS Trust, London, UK.

Introduction: Central nervous system (CNS) gliomas are the most common primary intra-axial brain tumours and pose variable treatment response according to their grade, therefore, precise staging is mandatory. Histopathological analysis of surgical tumour samples is still deemed as the state-of-the-art staging technique for gliomas due to the moderate specificity of the available non-invasive imaging modalities. A recently evolved analysis of the tissue water diffusion properties, known as diffusional kurtosis imaging (DKI), is a dimensionless metric, which quantifies water molecules' degree of non-Gaussian diffusion, hence reflects tissue microenvironment's complexity by means of non-invasive diffusion-weighted MRI acquisitions. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025123DOI Listing
December 2018

Behaviour change interventions for the management of Raynaud's phenomenon: a systematic literature review.

BMJ Open 2018 Dec 14;8(12):e024528. Epub 2018 Dec 14.

Centre for Pain Research, University of Bath, Bath, UK.

Objectives: Raynaud's phenomenon (RP) is a significant cause of morbidity. Vasodilator medications cause unwanted adverse effects, with behavioural and lifestyle changes forming the mainstay of self-management; this is difficult to implement successfully. The objectives of this study were to evaluate the efficacy of behaviour change interventions for RP and identify learning points for future treatment development. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024528DOI Listing
December 2018

Effectiveness of self-testing kits availability on improving HIV testing frequency for chinese men who have sex with men and their sexual partners: a protocol for a multicenter randomised controlled trial.

BMJ Open 2018 Dec 14;8(12):e024423. Epub 2018 Dec 14.

Xiangya Nursing School of Central South University, Changsha, China.

Introduction: HIV epidemic is increasing among men who have sex with men (MSM) in China, yet HIV testing uptake remains low. As an emerging approach, HIV self-testing (HIVST) has the potential to promote HIV testing coverage and frequency in this population. However, evidence of the effectiveness on implementation of HIVST among Chinese MSM and their sexual partners is scarce. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024423DOI Listing
December 2018

Reasons to stop drinking alcohol among patients with rheumatoid arthritis in Sweden: a mixed-methods study.

BMJ Open 2018 Dec 14;8(12):e024367. Epub 2018 Dec 14.

Spenshult Research and Development Center, Spenshult, Halmstad, Sweden.

Objectives: The aims were to identify patients with rheumatoid arthritis (RA) who had stopped drinking alcohol and compare them with patients drinking alcohol, and to explore reasons for stopping drinking alcohol.

Design: A sequential explanatory mixed methods design was used.

Setting: Six rheumatology clinics in Southern Sweden Better Anti-Rheumatic FarmacOTherapy cohort. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024367DOI Listing
December 2018

Comparison of the validity of checklist assessment in cardiac arrest simulations with an app in an academic hospital in Taiwan: a retrospective observational study.

BMJ Open 2018 Dec 14;8(12):e024309. Epub 2018 Dec 14.

Emergency Department, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.

Introduction: Robust assessment is a crucial component in Advanced Cardiac Life Support (ACLS) training to determine whether participants have achieved learning objectives with little or no variation in their overall outcomes. This study aimed to evaluate resuscitation performance by real-time logs. We hypothesised that instructors may not be able to evaluate time-sensitive parameters, namely, chest compression fraction, time to initiating chest compression and time to initiating defibrillation accurately in a subjective manner. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024309DOI Listing
December 2018

Supported self-management for people with type 2 diabetes: a meta-review of quantitative systematic reviews.

BMJ Open 2018 Dec 14;8(12):e024262. Epub 2018 Dec 14.

Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.

Objectives: Self-management support aims to give people with chronic disease confidence to actively manage their disease, in partnership with their healthcare provider. A meta-review can inform policy-makers and healthcare managers about the effectiveness of self-management support strategies for people with type 2 diabetes, and which interventions work best and for whom.

Design: A meta-review of systematic reviews of randomised controlled trials (RCTs) was performed adapting Cochrane methodology. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024262DOI Listing
December 2018
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Prognostic value of Modified Early Warning Score generated in a Chinese emergency department: a prospective cohort study.

BMJ Open 2018 Dec 14;8(12):e024120. Epub 2018 Dec 14.

Research Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Objectives: This study aimed to validate the performance of the Modified Early Warning Score (MEWS) in a Chinese emergency department and to determine the best cut-off value for in-hospital mortality prediction.

Design: A prospective, single-centred observational cohort study.

Setting: This study was conducted at a tertiary hospital in South China. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024120DOI Listing
December 2018
2.063 Impact Factor

Vascular and cognitive effects of cocoa-rich chocolate in postmenopausal women: a study protocol for a randomised clinical trial.

BMJ Open 2018 Dec 14;8(12):e024095. Epub 2018 Dec 14.

Primary Health Care Research Unit, La Alamedilla Health Center, Institute of Biomedical Research of Salamanca (IBSAL), Health Service of Castilla y León (SACyL), Salamanca, Spain.

Introduction: The intake of polyphenols has certain health benefits. This study will aim to assess the effect of adding a daily amount of chocolate high in cocoa content and polyphenols to the normal diet on blood pressure, vascular function, cognitive performance, quality of life and body composition in postmenopausal women.

Methods And Analysis: Here we plan a randomised clinical trial with two parallel groups involving a total of 140 women between 50 and 64 years in the postmenopausal period, defined by amenorrhoea of ​​at least 12 consecutive months. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02409
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http://dx.doi.org/10.1136/bmjopen-2018-024095DOI Listing
December 2018
1 Read

Risk factors for opioid-induced respiratory depression in surgical patients: a systematic review and meta-analyses.

BMJ Open 2018 Dec 14;8(12):e024086. Epub 2018 Dec 14.

Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Objective: This systematic review and meta-analysis aim to evaluate the risk factors associated with postoperative opioid-induced respiratory depression (OIRD).

Design: Systematic review and meta-analysis.

Data Sources: PubMed-MEDLINE, MEDLINE in-process, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, PubMed and Clinicaltrials. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024086DOI Listing
December 2018
1 Read
2.063 Impact Factor

Exploring patient safety in Swedish specialised home healthcare: an interview study with multidisciplinary teams and clinical managers.

BMJ Open 2018 Dec 14;8(12):e024068. Epub 2018 Dec 14.

Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.

Objective: Home healthcare is the fastest growing arena in the healthcare system but patient safety research in this context is limited. The aim was to explore how patient safety in Swedish specialised home healthcare is described and adressed from multidisciplinary teams' and clinical managers' perspectives.

Design: An explorative qualitative study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024068DOI Listing
December 2018

Informed shared decision-making programme for patients with type 2 diabetes in primary care: cluster randomised controlled trial.

BMJ Open 2018 Dec 14;8(12):e024004. Epub 2018 Dec 14.

Health Sciences and Education, University of Hamburg, Hamburg, Germany.

Objective: To translate an informed shared decision-making programme (ISDM-P) for patients with type 2 diabetes from a specialised diabetes centre to the primary care setting.

Design: Patient-blinded, two-arm multicentre, cluster randomised controlled trial of 6 months follow-up; concealed randomisation of practices after patient recruitment and acquisition of baseline data.

Setting: 22 general practices providing care according to the German Disease Management Programme (DMP) for type 2 diabetes. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024004DOI Listing
December 2018

Survival and new-onset morbidity after critical care admission for acute pancreatitis in Scotland: a national electronic healthcare record linkage cohort study.

BMJ Open 2018 Dec 14;8(12):e023853. Epub 2018 Dec 14.

Surgery, School of Medicine, University of Edinburgh, Edinburgh, UK.

Introduction: Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival.

Objective: To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP.

Design: Cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023853DOI Listing
December 2018
1 Read

Disability and morbidity among older patients in the emergency department: a Danish population-based cohort study.

BMJ Open 2018 Dec 14;8(12):e023803. Epub 2018 Dec 14.

Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark.

Objectives: The objective was to describe the prevalence of geriatric conditions among older medical patients in the emergency department (ED) and the association with admission, mortality, reattendance and loss of independency.

Design: Population-based prospective cohort study.

Setting: ED of a large university hospital. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023803DOI Listing
December 2018

Definition of whole person care in general practice in the English language literature: a systematic review.

BMJ Open 2018 Dec 14;8(12):e023758. Epub 2018 Dec 14.

Psycho-Oncology Co-operative Research Group, Sydney Health Ethics, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.

Objectives: The importance of 'whole person' or 'holistic' care is widely recognised, particularly with an increasing prevalence of chronic multimorbidity internationally. This approach to care is a defining feature of general practice. However, its precise meaning remains ambiguous. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023758DOI Listing
December 2018
1 Read

Is the decline in neonatal mortality in northern Ghana, 1996-2012, associated with the decline in the age of BCG vaccination? An ecological study.

BMJ Open 2018 Dec 14;8(12):e023752. Epub 2018 Dec 14.

Navrongo Health Research Centre, Navrongo, Ghana.

Objective: To examine the association between early Bacille Calmette-Guerin (BCG) vaccination and neonatal mortality in northern Ghana.

Methods: This ecological study used vaccination and mortality data from the Navrongo Health and Demographic Surveillance System. First, we assessed and compared changes in neonatal mortality rates (NMRs) and median BCG vaccination age from 1996 to 2012. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023752DOI Listing
December 2018

How is the audit of therapy intensity influencing rehabilitation in inpatient stroke units in the UK? An ethnographic study.

BMJ Open 2018 Dec 14;8(12):e023676. Epub 2018 Dec 14.

School of Population Health and Environmental Sciences, King's College London, London, UK.

Objectives: Occupational therapy, physiotherapy and speech and language therapy are central to rehabilitation after a stroke. The UK has introduced an audited performance target: that 45 min of each therapy should be provided to patients deemed appropriate. We sought to understand how this has influenced delivery of stroke unit therapy. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023676DOI Listing
December 2018

Motor imagery ability assessments in four disciplines: protocol for a systematic review.

BMJ Open 2018 Dec 14;8(12):e023439. Epub 2018 Dec 14.

Research Department, Reha Rheinfelden, Rheinfelden, Switzerland.

Introduction: Motor imagery (MI) is a very popular and well-accepted technique in different disciplines. Originating from sport and psychology, MI is now also used in the field of medicine and education. Several studies confirmed the benefits of MI to facilitate motor learning and skill acquisition. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023439DOI Listing
December 2018

Study protocol for a randomised controlled trial of humanoid robot-based distraction for venipuncture pain in children.

BMJ Open 2018 Dec 14;8(12):e023366. Epub 2018 Dec 14.

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Introduction: Intravenous insertion (IVI) is a very common procedure in the emergency department (ED). IVI is often painful and stressful for both children and their families. Currently, distraction therapy is not used as a standard of care for IVI in North America. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02336
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http://dx.doi.org/10.1136/bmjopen-2018-023366DOI Listing
December 2018
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Rationale and design of a single-blind, randomised controlled trial of exercise training for managing learning and memory impairment in persons with multiple sclerosis.

BMJ Open 2018 Dec 14;8(12):e023231. Epub 2018 Dec 14.

Kessler Foundation, Neuropsychology and Neuroscience Research, West Orange, New Jersey, USA.

Introduction: This randomised controlled trial (RCT) examines treadmill walking exercise training effects on learning and memory performance, hippocampal volume, and hippocampal resting-state functional connectivity in persons with multiple sclerosis (MS) who have objective impairments in learning new information.

Methods And Analysis: Forty fully ambulatory persons with MS who demonstrate objective learning and memory impairments will be randomly assigned into either the intervention or active control study conditions. The intervention condition involves supervised, progressive treadmill walking exercise training three times per week for a 3-month period. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023231DOI Listing
December 2018

Association of postlunch napping duration and night-time sleep duration with cognitive impairment in Chinese elderly: a cross-sectional study.

BMJ Open 2018 Dec 14;8(12):e023188. Epub 2018 Dec 14.

Director Office, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.

Objective: To analyse the independent and combined associations of postlunch napping duration and night-time sleep duration with risk of cognitive impairment among Chinese elderly.

Design: A cross-sectional study.

Setting: We analysed the data from Zhejiang Ageing and Health Cohort, a population-based survey of seven counties located in Zhejiang province in eastern China. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023188DOI Listing
December 2018

Selective carious tissue removal using subjective criteria or polymer bur: study protocol for a randomised controlled trial (SelecCT).

BMJ Open 2018 Dec 14;8(12):e022952. Epub 2018 Dec 14.

Department of Dentistry, School of Health Sciences, University of Brasília, Brasilia, Brazil.

Introduction: Selective (incomplete/partial) carious tissue removal is suitable for treating deep carious lesions in teeth with vital, asymptomatic pulps. In the periphery of a cavity, removal to hard dentin is performed, while in pulpo-proximal areas, leathery or soft dentin is left to avoid pulp exposure. As the decision of what contains 'soft' or 'leathery' dentin is subjective, using self-limiting burs which help to standardise the hardness of the remaining dentin, has been suggested to increase the reliability of carious tissue removal. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022952DOI Listing
December 2018

Comprehensive scoping review of health research using social media data.

BMJ Open 2018 Dec 14;8(12):e022931. Epub 2018 Dec 14.

Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.

Introduction: The rising popularity of social media, since their inception around 20 years ago, has been echoed in the growth of health-related research using data derived from them. This has created a demand for literature reviews to synthesise this emerging evidence base and inform future activities. Existing reviews tend to be narrow in scope, with limited consideration of the different types of data, analytical methods and ethical issues involved. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022931DOI Listing
December 2018

Qualitative exploration of sociocultural determinants of health inequities of Dalit population in Dhaka City, Bangladesh.

BMJ Open 2018 Dec 14;8(12):e022906. Epub 2018 Dec 14.

Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Objectives: In recent years, Bangladesh has made remarkable advances in health outcomes; however, the benefits of these gains are unequally shared among citizens and population groups. Dalits ( sweepers), a marginalised traditional working community, have relatively poor access to healthcare services. This study sought to explore the sociopolitical and cultural factors associated with health inequalities among Dalits in an urban setting. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022906DOI Listing
December 2018

Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis.

BMJ Open 2018 Dec 14;8(12):e022879. Epub 2018 Dec 14.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Objective: To investigate the efficacy and safety of the pulsed electromagnetic field (PEMF) therapy in treating osteoarthritis (OA).

Design: Meta-analysis.

Data Sources: PubMed, Embase, the Cochrane Library and Web of Science were searched through 13 October 2017. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022879DOI Listing
December 2018
1 Read

Development of a tool to assess beliefs about mythical causes of cancer: the Cancer Awareness Measure Mythical Causes Scale.

BMJ Open 2018 Dec 14;8(12):e022825. Epub 2018 Dec 14.

Research Department of Behavioural Science and Health, University College London, London, UK.

Objectives: We aimed to develop a reliable and valid measure to assess public beliefs in mythical causes of cancer: the Cancer Awareness Measure-MYthical Causes Scale (CAM-MYCS).

Design And Setting: Cancer myth items were generated from a literature review, social media and interviews (n=16). The CAM-MYCS was prepared by reducing items using (a) an online sample (n=527) with exploratory factor analysis and (b) cancer experts with Delhpi methodology (n=13). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022825DOI Listing
December 2018

Relationship between hospital or surgeon volume and outcomes in joint arthroplasty: protocol for a suite of systematic reviews and dose-response meta-analyses.

BMJ Open 2018 Dec 14;8(12):e022797. Epub 2018 Dec 14.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Introduction: Joint arthroplasty is a particularly complex orthopaedic surgical procedure performed on joints, including the hip, knee, shoulder, ankle, elbow, wrist and even digit joints. Increasing evidence from volume-outcomes research supports the finding that patients undergoing joint arthroplasty in high-volume hospitals or by high-volume surgeons achieve better outcomes, and minimum case load requirements have been established in some areas. However, the relationships between hospital/surgeon volume and outcomes in patients undergoing arthroplasty are not fully understood. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022797DOI Listing
December 2018

Cost of oropharyngeal dysphagia after stroke: protocol for a systematic review.

BMJ Open 2018 Dec 14;8(12):e022775. Epub 2018 Dec 14.

Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain.

Introduction: Oropharyngeal dysphagia (OD) is a major disorder following stroke. OD can produce alterations in both the efficacy and safety of deglutition and may result in malnutrition, dehydration, frailty, respiratory infections and pneumonia. These complications can be avoided by early detection and treatment of OD in poststroke patients, and hospital stays, medication and mortality rates can be reduced. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022775DOI Listing
December 2018

Predicting 7-year mortality for use with evidence-based guidelines for Prostate-Specific Antigen (PSA) testing: findings from a large prospective study of 123 697 Australian men.

BMJ Open 2018 Dec 14;8(12):e022613. Epub 2018 Dec 14.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objectives: To develop and validate a prediction model for short-term mortality in Australian men aged ≥45years, using age and self-reported health variables, for use when implementing the Australian Clinical Practice Guidelines for Prostate-Specific Antigen (PSA) Testing and Early Management of Test-Detected Prostate Cancer. Implementation of one of the Guideline recommendations requires an estimate of 7-year mortality.

Design: Prospective cohort study using questionnaire data linked to mortality data. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022613DOI Listing
December 2018

Costs and outcomes in evaluating management of unhealed surgical wounds in the community in clinical practice in the UK: a cohort study.

BMJ Open 2018 Dec 14;8(12):e022591. Epub 2018 Dec 14.

Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.

Objective: To evaluate the patient pathways and associated health outcomes, resource use and corresponding costs attributable to managing unhealed surgical wounds in clinical practice, from initial presentation in the community in the UK.

Methods: This was a retrospective cohort analysis of the records of 707 patients in The Health Improvement Network (THIN) database whose wound failed to heal within 4 weeks of their surgery. Patients' characteristics, wound-related health outcomes and healthcare resource use were quantified, and the total National Health Service (NHS) cost of patient management was estimated at 2015/2016 prices. Read More

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December 2018

Evaluation of stakeholder views on peer review of NIHR applications for funding: a qualitative study.

BMJ Open 2018 Dec 14;8(12):e022548. Epub 2018 Dec 14.

Wessex Institute, University of Southampton, Southampton, UK.

Objectives: Innovations resulting from research have both national and global impact, so selecting the most promising research studies to fund is crucial. Peer review of research funding applications is part of the selection process, and requires considerable resources. This study aimed to elicit stakeholder opinions about which factors contribute to and influence effective peer review of funding applications to the UK National Institute for Health Research (NIHR), and to identify possible minor improvements to current processes and any major changes or potential innovations to achieve a more efficient peer review process. Read More

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December 2018

Influence of external peer reviewer scores for funding applications on funding board decisions: a retrospective analysis of 1561 reviews.

BMJ Open 2018 Dec 14;8(12):e022547. Epub 2018 Dec 14.

Wessex Institute, Faculty of Medicine, University of Southampton, Southampton, UK.

Objectives: To evaluate the influence of external peer reviewer scores on the National Institute for Health Research (NIHR) research funding board decisions by the number of reviewers and type of reviewer expertise.

Design: Retrospective analysis of external peer review scores for shortlisted full applications for funding (280 funding applications, 1236 individual reviewers, 1561 review scores).

Setting: Four applied health research funding programmes of NIHR, UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022547DOI Listing
December 2018

Ten-year trends in traumatic brain injury: a retrospective cohort study of California emergency department and hospital revisits and readmissions.

BMJ Open 2018 Dec 14;8(12):e022297. Epub 2018 Dec 14.

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Objective: To describe visits and visit rates of adults presenting to emergency departments (EDs) with a diagnosis of traumatic brain injury (TBI). TBI is a major cause of death and disability in the USA; yet, current literature is limited because few studies examine longer-term ED revisits and hospital readmission patterns of TBI patients across a broad spectrum of injury severity, which can help inform potential unmet healthcare needs.

Design: We performed a retrospective cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022297DOI Listing
December 2018
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study: protocol for a stepped-wedge cluster randomised trial to compare access to care for a mobile app versus a workstation-based store-and-forward teledermatology process.

BMJ Open 2018 Dec 14;8(12):e022218. Epub 2018 Dec 14.

US Department of Veterans Affairs, Center for Access Policy, Evaluation and Research, Boston, Massachusetts, USA.

Introduction: Teledermatology has emerged as an important strategy to enhance access to high-quality skin care. is a provider-facing, web-based mobile app designed to integrate into the existing teledermatology workflow in the US Veterans Health Administration (VHA). In this study, we will conduct a systematic evaluation of on access outcomes in VHA facilities using a pragmatic trial guided by clinical and operational leaders. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022218DOI Listing
December 2018
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Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with a extract on cholesterol levels in adults with elevated fasting LDL cholesterol who are overweight or have obesity.

BMJ Open 2018 Dec 14;8(12):e022195. Epub 2018 Dec 14.

Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia.

Introduction: Hyperlipidaemia, hyperglycaemia and chronic inflammation are risk factors for chronic diseases cardiovascular disease and type 2 diabetes. Polyphenols are bioactive compounds found in marine algae with potential antihyperlipidaemic, antihyperglycaemic and anti-inflammatory effects. The modulation of these risk factors using bioactive polyphenols may represent a useful strategy for disease prevention and management; research in humans, however, remains limited. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022195DOI Listing
December 2018
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