12,174 results match your criteria BMJ open[Journal]


Wisdom of the caregivers: pooling individual subjective reports to diagnose states of consciousness in brain-injured patients, a monocentric prospective study.

BMJ Open 2019 Feb 21;9(2):e026211. Epub 2019 Feb 21.

Department of Neurology, Neuro ICU, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.

Objectives: The clinical distinction between vegetative state/unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) is a key step to elaborate a prognosis and formulate an appropriate medical plan for any patient suffering from disorders of consciousness (DoC). However, this assessment is often challenging and may require specialised expertise. In this study, we hypothesised that pooling subjective reports of the level of consciousness of a given patient across several nursing staff members can be used to clinically detect MCS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-026211DOI Listing
February 2019

Minimal important differences for improvement in shoulder condition patient-reported outcomes: a systematic review to inform a Rapid Recommendation.

BMJ Open 2019 Feb 20;9(2):e028777. Epub 2019 Feb 20.

Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Objectives: To identify credible anchor-based minimal important differences (MIDs) for patient-reported outcome measures (PROMs) relevant to a Rapid Recommendations addressing subacromial decompression surgery for shoulder pain.

Design: Systematic review.

Outcome Measures: Estimates of anchor-based MIDs, and their credibility, for PROMs judged by the parallel Rapid Recommendations panel as important for informing their recommendation (pain, function and health-related quality of life (HRQoL)). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-028777DOI Listing
February 2019

Trends in self-poisoning and psychotropic drug use in people aged 5-19 years: a population-based retrospective cohort study in Australia.

BMJ Open 2019 Feb 20;9(2):e026001. Epub 2019 Feb 20.

NSW Poisons Information Centre, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Objectives: To characterise trends in self-poisoning and psychotropic medicine use in young Australians.

Design: Population-based retrospective cohort study.

Setting: Calls taken by the New South Wales and Victorian Poisons Information Centres (2006-2016, accounting for 70% of Australian poisoning calls); medicine dispensings in the 10% sample of Australian Pharmaceutical Benefits Scheme data (July 2012 to June 2016). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-026001DOI Listing
February 2019

Transnasal Humidified Rapid Insufflation Ventilatory Exchange in children requiring emergent intubation (Kids THRIVE): a protocol for a randomised controlled trial.

BMJ Open 2019 Feb 20;9(2):e025997. Epub 2019 Feb 20.

Paediatric Critical Care Research Group (PCCRG), Queensland Children's Hospital and The University of Queensland, Brisbane, Queensland, Australia.

Introduction: Emergency intubation of children with abnormal respiratory or cardiac physiology is a high-risk procedure and associated with a high incidence of adverse events including hypoxemia. Successful emergency intubation is dependent on inter-related patient and operator factors. Preoxygenation has been used to maximise oxygen reserves in the patient and to prolong the safe apnoeic time during the intubation phase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025997DOI Listing
February 2019

Assessing the impact of artistic and cultural activities on the health and well-being of forcibly displaced people using participatory action research.

BMJ Open 2019 Feb 20;9(2):e025465. Epub 2019 Feb 20.

Genetics, Evolution and Environment, UCL Biosciences, University College London, London, UK.

Objective: Drawing on a growing body of research suggesting that taking part in artistic and cultural activities benefits health and well-being, the objective was to develop a participatory action research (PAR) method for assessing the impact of arts interventions on forcibly displaced people, and identify themes concerning perceived benefits of such programmes.

Design: A collaborative study following PAR principles of observation, focus groups and in-depth semistructured interviews.

Setting: London-based charity working with asylum seekers and refugees. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025465DOI Listing
February 2019

Does neighborhood socioeconomic status predict the risk of preterm birth? A community-based Canadian cohort study.

BMJ Open 2019 Feb 20;9(2):e025341. Epub 2019 Feb 20.

Department of Obstetrics and Gynecology and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.

Objective: This study developed and internally validated a predictive model for preterm birth (PTB) to examine the ability of neighbourhood socioeconomic status (SES) to predict PTB.

Design: Cohort study using individual-level data from two community-based prospective pregnancy cohort studies (All Our Families (AOF) and Alberta Pregnancy Outcomes and Nutrition (APrON)) and neighbourhood SES data from the 2011 Canadian census.

Setting: Calgary, Alberta, Canada. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025341DOI Listing
February 2019

Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: a protocol for a prospective case-control study.

BMJ Open 2019 Feb 20;9(2):e025246. Epub 2019 Feb 20.

Department of Research, Kreftregisteret, Oslo, Norway.

Introduction: The incidence of cutaneous melanoma (hereafter melanoma) has increased dramatically among fair-skinned populations worldwide. In Norway, melanoma is the most rapidly growing type of cancer, with a 47% increase among women and 57% among men in 2000-2016. Intermittent ultraviolet exposure early in life and phenotypic characteristics like a fair complexion, freckles and nevi are established risk factors, yet the aetiology of melanoma is multifactorial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025246DOI Listing
February 2019

Protocol for a systematic literature review and network meta-analysis of the clinical benefit of inhaled maintenance therapies in chronic obstructive pulmonary disease.

BMJ Open 2019 Feb 20;9(2):e025048. Epub 2019 Feb 20.

Department of Respiratory Epidemiology, Occupational Medicine and Public Health, Imperial College London, London, UK.

Introduction: Chronic obstructive pulmonary disease (COPD) exacerbations progress the course of disease and impair lung function. Inhaled maintenance therapy reduces exacerbations. It is not yet established which inhaled therapy combination is best to reduce exacerbations, lung function decline and symptom burden. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025048DOI Listing
February 2019

Is liver transplantation 'out-of-hours' non-inferior to 'in-hours' transplantation? A retrospective analysis of the UK Transplant Registry.

BMJ Open 2019 Feb 20;9(2):e024917. Epub 2019 Feb 20.

Sheila Sherlock Liver Centre, Royal Free Hospital and the UCL Institute for Liver and Digestive Health, London, UK.

Objectives: Increased morbidity and mortality have been associated with weekend and night-time clinical activity. We sought to compare the outcomes of liver transplantation (LT) between weekdays and weekends or night-time and day-time to determine if 'out-of-hours' LT has acceptable results compared with 'in-hours'.

Design, Setting And Participants: We conducted a retrospective analysis of patient outcomes for all 8816 adult, liver-only transplants (2000-2014) from the UK Transplant Registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-024917DOI Listing
February 2019

Google search histories of patients presenting to an emergency department: an observational study.

BMJ Open 2019 Feb 20;9(2):e024791. Epub 2019 Feb 20.

Department of Emergency Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Objective: To test patients' willingness to share and link their prior Google search histories with data from their electronic medical record (EMR), and to explore associations between search histories and clinical conditions.

Design: Cross-sectional study of emergency department (ED) patients from 2016 to 2017.

Setting: Academic medical centre ED. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-024791DOI Listing
February 2019

How do participant experiences and characteristics influence engagement in exercise referral? A qualitative longitudinal study of a scheme in Northumberland, UK.

BMJ Open 2019 Feb 20;9(2):e024370. Epub 2019 Feb 20.

Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

Objectives: Exercise referral schemes (ERSs) are internationally widespread. This study aimed to gain an insight into differential engagement through understanding participant experiences of patients referred by healthcare professionals to one such scheme in the UK.

Design: The study employed a qualitative longitudinal approach using semistructured interviews, with results reported using Consolidated criteria for Reporting Qualitative research guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-024370DOI Listing
February 2019

Cross-sectional comparison of health-related quality of life and other features in people with and without objective and subjective binge eating using a general population sample.

BMJ Open 2019 Feb 20;9(2):e024227. Epub 2019 Feb 20.

Translational Health Research Institure, School of Medicine, Western Sydney, Penrith, New South Wales, Australia.

Objectives: Evidence suggests that while objective binge eating (OBE) and subjective binge eating (SBE) differ in the amount of food consumed, both are associated with impairment in people with eating disorders. However, only OBE is accounted for in the diagnostic criteria of eating disorders. This study compared the sociodemographic profile and burden of OBE versus SBE at a population level. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-024227DOI Listing
February 2019

Impact of patient information leaflets on doctor-patient communication in the context of acute conditions: a prospective, controlled, before-after study in two French emergency departments.

BMJ Open 2019 Feb 20;9(2):e024184. Epub 2019 Feb 20.

Research Department, Grenoble Alpes University Hospital, Grenoble, France.

Objective: In the context of acute conditions seen in an emergency department, where communication may be difficult, patient information leaflets (PILs) could improve doctor-patient communication (DPC) and may have an impact on other outcomes of the consultation. Our objective was to assess the impact of PILs on DPC, patient satisfaction and adherence, and on patient and doctor behaviours.

Design: Prospective, controlled, before-after trial between November 2013 and June 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-024184DOI Listing
February 2019
1 Read

Adiposity measures and their validity in estimating risk of hypertension in South Asian children: a cross-sectional study.

BMJ Open 2019 Feb 20;9(2):e024087. Epub 2019 Feb 20.

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.

Objective: Given the South Asian phenotype of higher body fat at similar body mass index (BMI) relative to Caucasians, we sought to explore the association between prominent adiposity indicators with blood pressure (BP) and hypertension, to compare the accuracy of these indicators in estimating hypertension, and to provide cut-off values associated with adverse hypertension risk in South Asian children.

Design: Cross-sectional study.

Setting: Community-based recruitment in two Canadian cities (Hamilton and Surrey). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-024087DOI Listing
February 2019

Development and external validation of new nomograms by adding ECG changes (ST depression or tall T wave) and age to conventional scoring systems to improve the predictive capacity in patients with subarachnoid haemorrhage: a retrospective, observational study in Korea.

BMJ Open 2019 Feb 20;9(2):e024007. Epub 2019 Feb 20.

Emergency Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Objectives: To develop new nomograms by adding ECG changes (ST depression or tall T wave) and age to three conventional scoring systems, namely, World Federation of Neurosurgical Societies (WFNS) scale, Hunt and Hess (HH) system and Fisher scale, that can predict prognosis in patients with subarachnoid haemorrhage (SAH) using our preliminary research results and to perform external validation of the three new nomograms.

Design: Retrospective, observational study SETTING: Emergency departments (ED) of two university-affiliated tertiary hospital between January 2009 and March 2015.

Participants: Adult patients with SAH were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-024007DOI Listing
February 2019

Costs and effects of higher turnover of nurses and Aboriginal health practitioners and higher use of short-term nurses in remote Australian primary care services: an observational cohort study.

BMJ Open 2019 Feb 20;9(2):e023906. Epub 2019 Feb 20.

College of Medicine and Public Health, Flinders Northern Territory, Alice Springs, Northern Territory, Australia.

Objectives: To compare the costs and effects of higher turnover of resident nurses and Aboriginal health practitioners and higher use of agency-employed nurses in remote primary care (PC) services and quantify associations between staffing patterns and health outcomes in remote PC clinics in the Northern Territory (NT) of Australia.

Design: Observational cohort study, using hospital admission, financial and payroll data for the period 2013-2015.

Setting: 53 NT Government run PC clinics in remote communities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023906DOI Listing
February 2019

Use of biologics during pregnancy and risk of serious infections in the mother and baby: a Canadian population-based cohort study.

BMJ Open 2019 Feb 20;9(2):e023714. Epub 2019 Feb 20.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: To investigate the association between exposure to biologics during pregnancy and serious infections in mothers and infants.

Design: Retrospective cohort study.

Setting: Population-based. Read More

View Article

Download full-text PDF

Source
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02371
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-023714DOI Listing
February 2019
1 Read

Healthcare providers' perspectives on use of the national guideline for family planning services in Amhara Region, Ethiopia: a qualitative study.

BMJ Open 2019 Feb 20;9(2):e023403. Epub 2019 Feb 20.

School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia.

Objective: To explore healthcare providers' views on barriers to and facilitators of use of the national family planning (FP) guideline for FP services in Amhara Region, Ethiopia.

Design: Qualitative study.

Setting: Nine health facilities including two hospitals, five health centres and two health posts in Amhara Region, Northwest Ethiopia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023403DOI Listing
February 2019

Incidence and prognostic impact of post discharge bleeding post acute coronary syndrome within an outpatient setting: a systematic review.

BMJ Open 2019 Feb 20;9(2):e023337. Epub 2019 Feb 20.

Research Institute for Primary Care and Health Sciences, Keele University, Newcastle, UK.

Objective: The primary objective was to determine the incidence of bleeding events post acute coronary syndrome (ACS) following hospital discharge. The secondary objective was to determine the prognostic impact of bleeding on mortality, major adverse cardiovascular events (MACE), myocardial re-infarction and rehospitalisation in the postdischarge setting.

Design: A narrative systematic review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023337DOI Listing
February 2019

Non-inferiority double-blind randomised controlled trial comparing gabapentin versus tramadol for the treatment of chronic neuropathic or mixed pain in children and adolescents: the GABA-1 trial-a study protocol.

BMJ Open 2019 Feb 20;9(2):e023296. Epub 2019 Feb 20.

Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

Introduction: Gabapentin is currently used 'off-label' in children and adolescents with chronic neuropathic pain, and reliable evidence of its effects and optimal dosing are lacking.

Objectives: The GABA-1 trial aims to compare the efficacy and safety of gabapentin liquid formulation relative to tramadol and to explore the pharmacokinetics of both drugs in the treatment of chronic, neuropathic or mixed pain in the paediatric population.

Methods And Analysis: The trial is a multicentre, double-blind, double-dummy, randomised, active-controlled, non-inferiority trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023296DOI Listing
February 2019

Playing football on artificial turf as a risk factor for fifth metatarsal stress fracture: a retrospective cohort study.

BMJ Open 2019 Feb 20;9(2):e022864. Epub 2019 Feb 20.

Department of Orthopaedics and Sports Medicine, Juntendo University, Tokyo, Japan.

Objective: The fifth metatarsal stress fracture is a common injury among football players. Although several risk factors have been proposed, the association between the playing surface and development of fifth metatarsal stress fractures (MT-5) has not been evaluated. We conducted an epidemiological study using a computer-based survey to investigate the association between the playing surface and development of MT-5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-022864DOI Listing
February 2019

Utility of the number needed to treat in paediatric haematological cancer randomised controlled treatment trials: a systematic review.

BMJ Open 2019 Feb 20;9(2):e022839. Epub 2019 Feb 20.

School Of Nursing, University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: The primary objective was to assess the utility of the number needed to treat (NNT) to inform decision-making in the context of paediatric oncology and to calculate the NNT in all superiority, parallel, paediatric haematological cancer, randomised controlled trials (RCTs), with a comparison to the threshold NNT as a measure of clinical significance.

Design: Systematic review DATA SOURCES: MEDLINE, EMBASE and the Cochrane Childhood Cancer Group Specialized Register through CENTRAL from inception to August 2018.

Eligibility Criteria For Selecting Studies: Superiority, parallel RCTs of haematological malignancy treatments in paediatric patients that assessed an outcome related to survival, relapse or remission; reported a sample size calculation with a delta value to allow for calculation of the threshold NNT, and that included parameters required to calculate the NNT and associated CI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-022839DOI Listing
February 2019

Effect of text messaging on depression in patients with coronary heart disease: a substudy analysis from the TEXT ME randomised controlled trial.

BMJ Open 2019 Feb 20;9(2):e022637. Epub 2019 Feb 20.

The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Objective: We aimed to evaluate the effects on depression scores of a lifestyle-focused cardiac support programme delivered via mobile phone text messaging among patients with coronary heart disease (CHD).

Design: Substudy and secondary analysis of a parallel-group, single-blind randomised controlled trial of patients with CHD.

Setting: A tertiary hospital in Sydney, Australia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-022637DOI Listing
February 2019

Who pays and how much? A cross-sectional study of out-of-pocket payment for modern contraception in Kenya.

BMJ Open 2019 Feb 20;9(2):e022414. Epub 2019 Feb 20.

Faculty of Epidemiology & Population Health, London School of Hygiene and Tropical Medicine, London, UK.

Objectives: Out-of-pocket (OOP) payment for modern contraception is an understudied component of healthcare financing in countries like Kenya, where wealth gradients in met need have prompted efforts to expand access to free contraception. This study aims to examine whether, among public sector providers, the poor are more likely to receive free contraception and to compare how OOP payment for injectables and implants-two popular methods-differs by public/private provider type and user's sociodemographic characteristics.

Design, Setting And Participants: Secondary analyses of nationally representative, cross-sectional household data from the 2014 Kenya Demographic and Health Survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-022414DOI Listing
February 2019

Exploring variation in patient access of post-discharge physiotherapy following total hip and knee arthroplasty under a choice based system in the UK: an observational cohort study.

BMJ Open 2019 Feb 20;9(2):e021614. Epub 2019 Feb 20.

Department of Orthopaedics and Trauma, University of Edinburgh, Edinburgh, UK.

Objectives: To assess a targeted 'therapy as required' model of post-discharge outpatient physiotherapy provision. Specifically, we investigated what proportion of patients accessed post-discharge physiotherapy following total hip arthroplasty (THA) and total knee arthroplasty (TKA), whether accessing therapy was associated with post-arthroplasty patient reported outcomes and whether it was possible to predict which patients would access post-discharge physiotherapy from pre-operative data.

Design: Prospective, observational, longitudinal cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-021614DOI Listing
February 2019

Correction: .

Authors:

BMJ Open 2019 Feb 19;9(2):e019184corr1. Epub 2019 Feb 19.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2017-019184corr1DOI Listing
February 2019

Correction: .

Authors:

BMJ Open 2019 Feb 19;9(2):e014835corr1. Epub 2019 Feb 19.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2016-014835corr1DOI Listing
February 2019

Microsimulation model for the health economic evaluation of osteoporosis interventions: study protocol.

BMJ Open 2019 Feb 18;9(2):e028365. Epub 2019 Feb 18.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Introduction: Osteoporosis is a systemic skeletal disease that is characterised by reduced bone strength and increased fracture risk. Osteoporosis-related fractures impose enormous disease and economic burden to the society. Although many treatments and health interventions are proven effective to prevent fractures, health economic evaluation adds evidence to their economic merits. Read More

View Article

Download full-text PDF

Source
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02836
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-028365DOI Listing
February 2019
3 Reads

Safety and efficacy of 2% chlorhexidine gluconate aqueous versus 2% chlorhexidine gluconate in 70% isopropyl alcohol for skin disinfection prior to percutaneous central venous catheter insertion in preterm neonates: the ARCTIC randomised-controlled feasibility trial protocol.

BMJ Open 2019 Feb 19;9(2):e028022. Epub 2019 Feb 19.

Paediatric Infectious Diseases Research Group, Infection and Immunity, St George's University of London, London, UK.

Introduction: Catheter-related sepsis is one of the most dangerous complications of neonatal intensive care and is associated with significant morbidity and mortality. Use of catheter-care 'bundles' has reduced the incidence of catheter-related sepsis, although individual components have not been well studied. Better evidence is needed to guide selection of the most appropriate antiseptic solution for skin disinfection in preterm neonates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-028022DOI Listing
February 2019

Necessity of dural tenting sutures in modern neurosurgery: protocol for a systematic review.

BMJ Open 2019 Feb 19;9(2):e027904. Epub 2019 Feb 19.

Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland.

Introduction: The ongoing need for dural tenting sutures in a contemporary neurosurgical practice has been questioned in the literature for over two decades. In the past, these sutures were supposed to prevent blood collecting in the potential space between the skull and the dura by elevating the latter. Theoretically, with modern haemostasis and proper postoperative care, this technique should not be necessary and the surgery time can be shortened. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-027904DOI Listing
February 2019

Resuscitative endovascular balloon occlusion of the aorta (REBOA): a scoping review protocol concerning indications-advantages and challenges of implementation in traumatic non-compressible torso haemorrhage.

BMJ Open 2019 Feb 19;9(2):e027572. Epub 2019 Feb 19.

Department of Trauma and Acute Surgical Care, McGill University Health Centre, Montreal, Quebec, Canada.

Introduction: Haemorrhage remains the leading cause of preventable death in trauma. Damage control measures applied to patients in extremis in order to control exsanguinating bleeding from non-compressible torso injuries use different techniques to limit blood flow from the aorta to the rest of the body. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is regaining momentum recently as an adjunct measure that can provide the same results using less invasive approaches. Read More

View Article

Download full-text PDF

Source
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02757
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-027572DOI Listing
February 2019
1 Read

Physiotherapy after anterior cervical spine surgery for cervical disc disease: study protocol of a prospective randomised study to compare internet-based neck-specific exercise with prescribed physical activity.

BMJ Open 2019 Feb 19;9(2):e027387. Epub 2019 Feb 19.

Neuro-Orthopedic Center, Ryhov Hospital, Jönköping, Sweden.

Introduction: Patients suffering from remaining disability after anterior cervical decompression and fusion (ACDF) surgery for cervical disc disease may be prescribed physical activity (PPA) or neck-specific exercises (NSEs). Currently, we lack data for the success of either approach. There is also a knowledge gap concerning the use of internet-based care for cervical disc disease. Read More

View Article

Download full-text PDF

Source
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02738
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-027387DOI Listing
February 2019
2 Reads

Implementation of the WHO manual for Robson classification: an example from Sri Lanka using a local database for developing quality improvement recommendations.

BMJ Open 2019 Feb 19;9(2):e027317. Epub 2019 Feb 19.

WHO Collaborating Centre for Maternal and Child Health, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.

Objectives: This study aimed at describing the use of a prospective database on hospital deliveries for analysing caesarean section (CS) practices according to the WHO manual for Robson classification, and for developing recommendations for improving the quality of care (QoC).

Design: Observational study.

Setting: University Obstetric Unit at De Soysa Hospital for Women, the largest maternity unit in Sri Lanka. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-027317DOI Listing
February 2019

Self-harm and social media: thematic analysis of images posted on three social media sites.

BMJ Open 2019 Feb 19;9(2):e027006. Epub 2019 Feb 19.

Division of Psychological and Social Medicine, University of Leeds, Leeds, UK.

Objectives: To explore the nature of images tagged as self-harm on popular social media sites and what this might tell us about how these sites are used.

Design: A visual content and thematic analysis of a sample of 602 images captured from Twitter, Instagram and Tumblr.

Results: Over half the images tagged as self-harm had no explicit representation of self-harm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-027006DOI Listing
February 2019

Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study.

BMJ Open 2019 Feb 19;9(2):e027004. Epub 2019 Feb 19.

Genomic and Genetic Diagnosis Unit, Research Foundation of Valencia University Clinical Hospital-INCLIVA, Valencia, Spain.

Objective: To study the association of genes involved in the mitochondrial respiratory chain (MRC) pathway with body mass index (BMI) and obesity risk.

Design: This work studies three cross-sectional populations from Spain, representing three provinces: HORTEGA (Valladolid, Northwest/Centre), SEGOVIA (Segovia, Northwest/centre) and PIZARRA (Malaga,South).

Setting: Forty-eight single nucleotide polymorphisms (SNPs) from MRC genes were selected and genotyped by SNPlex method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-027004DOI Listing
February 2019

Diagnostic accuracy of the Xpert CT/NG and OSOM Trichomonas Rapid assays for point-of-care STI testing among young women in South Africa: a cross-sectional study.

BMJ Open 2019 Feb 19;9(2):e026888. Epub 2019 Feb 19.

Centre for the AIDS Programme in South Africa (CAPRISA), Durban, South Africa.

Objectives: Syndromic management of sexually transmitted infections (STIs) omits asymptomatic infections, particularly among women. Accurate point-of-care assays may improve STI care in low- and middle-income countries (LMICs). We aimed to evaluate the diagnostic performance of the Xpert / (CT/NG) and OSOM (TV) Test as part of a STI care model for young women in South Africa. Read More

View Article

Download full-text PDF

Source
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02688
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-026888DOI Listing
February 2019
2 Reads

Medicine authentication technology: a quantitative study of incorrect quarantine, average response times and offline issues in a hospital setting.

BMJ Open 2019 Feb 19;9(2):e026619. Epub 2019 Feb 19.

Said Business School, University of Oxford, Oxford, UK.

Objectives: To introduce serialised medicines into an operational hospital dispensary and assess the technical effectiveness of digital medicine authentication (MA) technology under European Union Falsified Medicines Directive (EU FMD) conditions.

Design: Thirty medicine lines were serialised using 2D data matrix labels and introduced into an operational UK National Health Service (NHS) hospital dispensary. Staff were asked to check medicines for two-dimensional (2D) data matrices and scan those products, in addition to their usual medicine preparation and checking processes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-026619DOI Listing
February 2019

Selective citation in the literature on the hygiene hypothesis: a citation analysis on the association between infections and rhinitis.

BMJ Open 2019 Feb 19;9(2):e026518. Epub 2019 Feb 19.

Nutrition and Translational Research in Metabolism (School NUTRIM), Maastricht University, Maastricht, Limburg, The Netherlands.

Objective: Our objective was to assess the occurrence and determinants of selective citation in scientific publications on Strachan's original hygiene hypothesis. His hypothesis states that lack of exposure to infections in early childhood increases the risk of rhinitis.

Setting: Web of Science Core Collection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-026518DOI Listing
February 2019

Effect of integrated urban and rural residents medical insurance on the utilisation of medical services by residents in China: a propensity score matching with difference-in-differences regression approach.

BMJ Open 2019 Feb 19;9(2):e026408. Epub 2019 Feb 19.

Department of Health Management, School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: In this study, we aim to evaluate the effect of urban and rural resident medical insurance scheme (URRMI) on the utilisation of medical services by urban and rural residents in the four pilot provinces.

Setting And Participants: The sample used in this study is 13 305 individuals, including 2620 in the treatment group and 10 685 in the control group, from the 2011 and 2015 surveys of China Health and Retirement Longitudinal Study.

Outcome Measures: Propensity score matching and difference-in-differences regression approach (PSM-DID) is used in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-026408DOI Listing
February 2019

Precarious employment, business performance and occupational injuries: a study protocol of a register-based Swedish project.

BMJ Open 2019 Feb 19;9(2):e026091. Epub 2019 Feb 19.

Unit of Occupational Medicine, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Introduction: There is uncertainty regarding the trends in occupational injuries (OIs) in Sweden due to a significant and increasing problem with under-reporting to injury registers. Under-reporting, in general, is likely to be exacerbated by the rise in precarious employment (PE), a set of unfavourable employment characteristics that would benefit from formal definition and study. PE and global trends are believed also to affect companies and their commitment to health and safety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-026091DOI Listing
February 2019

Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy.

BMJ Open 2019 Feb 19;9(2):e025939. Epub 2019 Feb 19.

Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.

Purpose: A prospective cohort study for pregnant women, the Maternity Log study, was designed to construct a time-course high-resolution reference catalogue of bioinformatic data in pregnancy and explore the associations between genomic and environmental factors and the onset of pregnancy complications, such as hypertensive disorders of pregnancy, gestational diabetes mellitus and preterm labour, using continuous lifestyle monitoring combined with multiomics data on the genome, transcriptome, proteome, metabolome and microbiome.

Participants: Pregnant women were recruited at the timing of first routine antenatal visits at Tohoku University Hospital, Sendai, Japan, between September 2015 and November 2016. Of the eligible women who were invited, 65. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025939DOI Listing
February 2019

Making headlines: an analysis of US government-funded cancer research mentioned in online media.

BMJ Open 2019 Feb 19;9(2):e025783. Epub 2019 Feb 19.

Simon Fraser University at Harbour Centre, Vancouver, British Columbia, Canada.

Objective: To characterise how online media coverage of journal articles on cancer funded by the US government varies by cancer type and stage of the cancer control continuum and to compare the disease prevalence rates with the amount of funded research published for each cancer type and with the amount of media attention each receives.

Design: A cross-sectional study.

Setting: The United States. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025783DOI Listing
February 2019

Chronic heart failure patients' experiences of German healthcare services: a protocol for a scoping review.

BMJ Open 2019 Feb 19;9(2):e025685. Epub 2019 Feb 19.

Institute of General Practice, Goethe University Frankfurt, Frankfurt, Germany.

Introduction: Chronic heart failure (CHF) is a heterogeneous condition requiring complex treatment from diverse healthcare services. An increasingly holistic understanding of healthcare has resulted in contextual factors such as perceived quality of care, as well as patients' acceptance, preferences and subjective expectations of health services, all gaining in importance. How patients with CHF experience the use of healthcare services has not been studied within the scope of a systematic review in a German healthcare context. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025685DOI Listing
February 2019

'Just because I'm old it doesn't mean I have to be fat': a qualitative study exploring older adults' views and experiences of weight management.

BMJ Open 2019 Feb 19;9(2):e025680. Epub 2019 Feb 19.

Department of Behavioural Science and Health, University College London, London, UK.

Objectives: The aim of this study was to explore older adults' beliefs about the appropriateness of weight management, and how their experiences and expectations of weight management have changed as they have got older.

Design: Qualitative semistructured interview study.

Setting: UK. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025680DOI Listing
February 2019

Protocol for developing a mental imagery intervention: a randomised controlled trial testing a novel implementation imagery e-health intervention to change driver behaviour during floods.

BMJ Open 2019 Feb 19;9(2):e025565. Epub 2019 Feb 19.

School of Psychology, Health Psychology and Behavioural Medicine Research Group, Curtin University, Perth, Western Australia, Australia.

Introduction: Drowning due to driving into floodwater accounts for a significant proportion of all deaths by drowning. Despite awareness campaigns such as 'If it's flooded, forget it', people continue to drive into floodwater. This causes loss of life, risk to rescuers and damage to vehicles. Read More

View Article

Download full-text PDF

Source
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02556
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-025565DOI Listing
February 2019
1 Read

Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda.

BMJ Open 2019 Feb 19;9(2):e025469. Epub 2019 Feb 19.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Introduction: Schizophrenia and bipolar disorder account for a large proportion of the global burden of disease. Despite their enormous impact, little is known about their pathophysiology. Given the high heritability of schizophrenia and bipolar disorder, unbiased genetic studies offer the opportunity to gain insight into their neurobiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025469DOI Listing
February 2019

Healthcare professionals' perceptions of learning communication in the healthcare workplace: an Australian interview study.

BMJ Open 2019 Feb 19;9(2):e025445. Epub 2019 Feb 19.

Monash Centre for Scholarship in Health Education (MCSHE), Monash University, Clayton, Victoria, Australia.

Objectives: The literature focuses on teaching communication skills in the 'classroom', with less focus on how such skills are informally learnt in the healthcare workplace. We grouped healthcare work based on the cure:care continuum to explore communication approaches based on work activities. This study asks: 1) How do healthcare professionals believe they learn communication in the workplace? 2) What are the differences (if any) across the 'type of work' as represented by the cure:care continuum?

Design: This qualitative study used semi-structured individual interviews. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025445DOI Listing
February 2019

Prevalence of amblyopia and strabismus in Hani school children in rural southwest China: a cross-sectional study.

BMJ Open 2019 Feb 19;9(2):e025441. Epub 2019 Feb 19.

Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Purpose: To determine the prevalence rate of amblyopia and strabismus in Chinese Hani ethnic school-aged children.

Methods: All grade 1 and grade 7 students in Mojiang Hani Autonomous County, located in southwest China, were invited for comprehensive eye examinations performed by experienced ophthalmologists and optometrists, including visual acuity, ocular alignment and movements, cycloplegic autorefraction, anterior segment and fundus examinations. Standard definitions of amblyopia and strabismus were applied to calculate their prevalence rate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025441DOI Listing
February 2019