12,794 results match your criteria BMJ open[Journal]


Primary Care SHOPping intervention for cardiovascular disease prevention (PC-SHOP): protocol for a randomised controlled trial to reduce saturated fat intake.

BMJ Open 2019 Apr 15;9(4):e027035. Epub 2019 Apr 15.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Introduction: A diet high in saturated fat (SFA) increases the risk of cardiovascular disease (CVD) and intakes in the UK exceed dietary recommendations. The Primary Care Shopping Intervention for Cardiovascular Disease Prevention (PC-SHOP) study aims to test the effect of an intervention for people with raised low-density lipoprotein (LDL) cholesterol involving health professional (HP) advice alone, or in combination with personalised feedback based on nutritional analysis of grocery store loyalty card data, on SFA intake and blood lipids in comparison with no intervention.

Methods And Analysis: PC-SHOP is a three-arm parallel randomised controlled trial with an allocation ratio of 1:3:3 ('no intervention': n=16, 'brief support': n=48, 'brief support plus shopping feedback': n=48, respectively). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027035DOI Listing

Quantitative examination of the bone health status of older adults with intellectual and developmental disability in Ireland: a cross-sectional nationwide study.

BMJ Open 2019 Apr 15;9(4):e026939. Epub 2019 Apr 15.

Dean of the Faculty of Health Sciences, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

Objectives: (1) To investigate the prevalence of osteopenia and osteoporosis among adults with intellectual disabilities (IDs) and (2) to examine alternative optimal bone screening techniques.

Design: Observational cross-sectional study.

Setting: Wave 2 (2013-2106) of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026939DOI Listing

What enables older people to continue with their falls prevention exercises? A qualitative systematic review.

BMJ Open 2019 Apr 15;9(4):e026074. Epub 2019 Apr 15.

RCN RI, Royal College of Nursing Research Institute, Warwick Medical School, University of Warwick, Coventry, UK.

Objectives: To review the qualitative literature that explores the barriers and facilitators to continued participation in falls prevention exercise after completion of a structured exercise programme.

Design: A systematic literature review with thematic synthesis of qualitative studies exploring older adults' experiences of continued participation in falls prevention exercise.

Data Sources: Comprehensive searches were conducted in MEDLINE, PSYCHinfo, AMED, ASSIA, CINAHL and EMBASE from inception until November 2017. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026074DOI Listing

Diabetes in pregnancy in associations with perinatal and postneonatal mortality in First Nations and non-Indigenous populations in Quebec, Canada: population-based linked birth cohort study.

BMJ Open 2019 Apr 15;9(4):e025084. Epub 2019 Apr 15.

Obstetrics and Gynecology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Objective: Both pregestational and gestational diabetes mellitus (PGDM, GDM) occur more frequently in First Nations (North American Indians) pregnant women than their non-Indigenous counterparts in Canada. We assessed whether the impacts of PGDM and GDM on perinatal and postneonatal mortality may differ in First Nations versus non-Indigenous populations.

Design: A population-based linked birth cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025084DOI Listing
April 2019
1 Read

Persistence with opioids post discharge from hospitalisation for surgery in Australian adults: a retrospective cohort study.

BMJ Open 2019 Apr 16;9(4):e023990. Epub 2019 Apr 16.

Quality Use of Medicines and Pharmacy Research Centre, University of South Australia Division of Health Sciences, Adelaide, South Australia, Australia.

Objective: To determine time to opioid cessation post discharge from hospital in persons who had been admitted to hospital for a surgical procedure and were previously naïve to opioids.

Design, Setting And Participants: Retrospective cohort study using administrative health claims database from the Australian Government Department of Veterans' Affairs (DVA). DVA gold card holders aged between 18 and 100 years who were admitted to hospital for a surgical admission between 1 January 2014 and 30 December 2015 and naïve to opioid therapy prior to admission were included in the study. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02399
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http://dx.doi.org/10.1136/bmjopen-2018-023990DOI Listing
April 2019
1 Read

Designing and evaluating provider results-based financing for tuberculosis care in Georgia: a realist evaluation protocol.

BMJ Open 2019 Apr 14;9(4):e030257. Epub 2019 Apr 14.

Department of Public Health, Institute of Tropical Medicine, Health Systems and Equity Unit, Antwerp, Belgium.

Introduction: In 2016, Georgian researchers and policymakers were developing a policy to improve the performance of the national tuberculosis (TB) control programme. The research programme 'Designing and Evaluating Provider Results-Based Financing for Tuberculosis Care in Georgia: Understanding Costs, Mechanisms of Effect and Impact (Results4TB)' was initiated to inform the policy formulation phase, document the policy implementation and assess the effectiveness, cost-effectiveness and the processes of change. To achieve this, the research team intends to combine an impact evaluation, a cost-effectiveness study and a realist evaluation (RE) within an overarching theory-informed design. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-030257DOI Listing

Exploring standardisation, monitoring and training of medical devices in assisted vaginal birth studies: protocol for a systematic review.

BMJ Open 2019 Apr 14;9(4):e028300. Epub 2019 Apr 14.

Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Bristol, UK.

Introduction: Assisted vaginal birth (AVB) can markedly improve maternal and neonatal outcomes arising from complications in the second stage of labour. Historically, both forceps and ventouse devices have been used to assist birth; however, they are not without risk and are associated with complications, such as cephalohaematoma, retinal haemorrhage and perineal trauma. As new devices are developed to overcome the limitations of existing techniques, it is necessary to establish their efficacy and effectiveness within randomised controlled trials (RCTs). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028300DOI Listing
April 2019
1 Read

Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: qualitative study.

BMJ Open 2019 Apr 14;9(4):e028122. Epub 2019 Apr 14.

Institute for Ageing and Health, Newcastle University, Newcastle, UK.

Objective: To explore the role of the novel cardiac output response to stress (CORS), test in the current diagnostic pathway for heart failure and the opportunities and challenges to potential implementation in primary care.

Design: Qualitative study using semistructured in-depth interviews which were audio recorded and transcribed verbatim. Data from the interviews were analysed thematically using an inductive approach. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028122DOI Listing

Are changes in physical fitness, body composition and weight associated with exercise attendance and dropout among fitness club members? Longitudinal prospective study.

BMJ Open 2019 Apr 14;9(4):e027987. Epub 2019 Apr 14.

Department of Sports Medicine, Norwegian School of Sports Sciences, Oslo, Norway.

Objectives: The primary aim of the present study was to investigate if changes in physical fitness, body composition and weight are associated with exercise attendance and dropout among fitness club members. Secondary, we wanted to identify motives for fitness club membership and exercise.

Setting: New members at 25 fitness clubs in Oslo, Norway. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027987DOI Listing

Visual impairment and objectively measured physical activity and sedentary behaviour in US adolescents and adults: a cross-sectional study.

BMJ Open 2019 Apr 14;9(4):e027267. Epub 2019 Apr 14.

Department of Epidemiology, Medical University of Vienna, Austria, Vienna, Austria.

Objectives: To compare levels of physical activity and sedentary time in a representative sample of US adolescents and adults with and without visual impairment.

Design: Cross-sectional analyses were carried out using data from the National Health and Nutrition Examination Survey.

Participants: The study population consisted of 6001 participants (adolescents n=1766, adults n=4235). Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02726
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http://dx.doi.org/10.1136/bmjopen-2018-027267DOI Listing
April 2019
1 Read
2.063 Impact Factor

Real-world persistence and adherence with oral bisphosphonates for osteoporosis: a systematic review.

BMJ Open 2019 Apr 14;9(4):e027049. Epub 2019 Apr 14.

Department of Health Professions, Manchester Metropolitan University, Manchester, UK.

Objectives: This study examined patient adherence and persistence to oral bisphosphonates for the treatment of osteoporosis in real-world settings.

Methods: A systematic review was completed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Medical Literature Analysis and Retrieval System Online (MEDLINE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Allied and Complementary Medicine Database (AMED), Database of Abstracts of Reviews of Effects (DARE), Health Technology Assessment (HTA) and National Health Service Economic Evaluation Database NHS EED) databases were searched for studies published in English language up to April 2018. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02704
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http://dx.doi.org/10.1136/bmjopen-2018-027049DOI Listing
April 2019
2 Reads

Cost-effectiveness of faecal calprotectin used in primary care in the diagnosis of inflammatory bowel disease.

BMJ Open 2019 Apr 14;9(4):e027043. Epub 2019 Apr 14.

Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, Canada.

Objective: Inflammatory bowel disease (IBD) is a chronic, autoimmune, gastrointestinal disorder. Canada has one of the highest prevalence and incidence rates of IBD in the world. Diagnosis is challenging due to the similarity of symptoms to functional gastrointestinal disorders. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027043DOI Listing

Involving the general practitioner during curative cancer treatment: a systematic review of health care interventions.

BMJ Open 2019 Apr 14;9(4):e026383. Epub 2019 Apr 14.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Objective: The role of primary care providers (PCP) in the cancer care continuum is expanding. In the post-treatment phase, this role is increasingly recognised by policy makers and healthcare professionals. During treatment, however, the role of PCP remains largely undefined. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02638
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http://dx.doi.org/10.1136/bmjopen-2018-026383DOI Listing
April 2019
2 Reads

Walk, Talk and Listen: a pilot randomised controlled trial targeting functional fitness and loneliness in older adults with hearing loss.

BMJ Open 2019 Apr 14;9(4):e026169. Epub 2019 Apr 14.

Medicine, University of British Columbia, Kelowna, British Columbia, Canada.

Background: Age-related hearing loss (HL) is a prevalent disability associated with loneliness, isolation, declines in cognitive and physical function and premature mortality. Group audiological rehabilitation (GAR) and hearing technologies address communication and cognitive decline. However, the relationship between loneliness, physical function and GAR among older adults with HL has not been studied. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026169DOI Listing
April 2019
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Does exercise impact gut microbiota composition in men receiving androgen deprivation therapy for prostate cancer? A single-blinded, two-armed, randomised controlled trial.

BMJ Open 2019 Apr 14;9(4):e024872. Epub 2019 Apr 14.

Exercise Medicine Research Institute, Edith Cowan University, Perth, Western Australia, Australia.

Introduction: A potential link exists between prostate cancer (PCa) disease and treatment and increased inflammatory levels from gut dysbiosis. This study aims to examine if exercise favourably alters gut microbiota in men receiving androgen deprivation therapy (ADT) for PCa. Specifically, this study will explore whether: (1) exercise improves the composition of gut microbiota and increases the abundance of bacteria associated with health promotion and (2) whether gut health correlates with favourable inflammatory status, bowel function, continence and nausea among patients participating in the exercise intervention. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024872DOI Listing
April 2019
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Exploring the impacts of the 2012 Health and Social Care Act reforms to commissioning on clinical activity in the English NHS: a mixed methods study of cervical screening.

BMJ Open 2019 Apr 14;9(4):e024156. Epub 2019 Apr 14.

Division of Population Health, Health Services Research, and Primary Care, University of Manchester, Manchester, UK.

Objectives: Explore the impact of changes to commissioning introduced in England by the Health and Social Care Act 2012 (HSCA) on cervical screening activity in areas identified empirically as particularly affected organisationally by the reforms.

Methods: Qualitative followed by quantitative methods. Qualitative: semi-structured interviews (with NHS commissioners, managers, clinicians, senior administrative staff from Clinical Commissioning Groups (CCGs), local authorities, service providers), observations of commissioning meetings in two metropolitan areas of England. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024156DOI Listing

Co-prescription patterns of cardiovascular preventive treatments: a cross-sectional study in the Aragon worker' health study (Spain).

BMJ Open 2019 Apr 14;9(4):e023571. Epub 2019 Apr 14.

Microbiology, Preventive Medicine and Public Health, Universidad de Zaragoza, Zaragoza, Spain.

Objectives: To identify cardiovascular disease (CVD) preventive treatments combinations, among them and with other drugs, and to determine their prevalence in a cohort of Spanish workers.

Design: Cross-sectional study.

Setting: Aragon Workers' Health Study (AWHS) cohort in Spain. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023571DOI Listing

International normative data for paediatric foot posture assessment: a cross-sectional investigation.

BMJ Open 2019 Apr 14;9(4):e023341. Epub 2019 Apr 14.

Podiatry, La Trobe University College of Science Health and Engineering, Bundoora, Victoria, Australia.

Objectives: The foot posture index (FPI) is an observational tool designed to measure the position of the foot. The objective of this study was to establish international reference data for foot posture across childhood, and influence of body mass index (BMI) on paediatric foot posture.

Design: Cross-sectional study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023341DOI Listing

Cost and cost-effectiveness of mHealth interventions for the prevention and control of type 2 diabetes mellitus: a protocol for a systematic review.

BMJ Open 2019 Apr 11;9(4):e027490. Epub 2019 Apr 11.

Institute for Global Health, University College London, London, UK.

Introduction: Type 2 diabetes mellitus (T2DM) remains one of the most common chronic diseases of adulthood which creates high degrees of morbidity and mortality worldwide. The incidence of T2DM continues to rise and recently, mHealth interventions have been increasingly used in the prevention, monitoring and management of T2DM. The aim of this study is to systematically review the published evidence on cost and cost-effectiveness of mHealth interventions for T2DM, as well as assess the quality of reporting of the evidence. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027490DOI Listing
April 2019
1 Read

Strategies occupational therapists employ to facilitate work-related transitions for persons with hand injuries: a study protocol for a scoping review.

BMJ Open 2019 Apr 11;9(4):e027402. Epub 2019 Apr 11.

Occupational Therapy, Stellenbosch University Department of Medicine, Cape Town, South Africa.

Introduction: Hands make it possible to be employable and productive, to communicate non-verbally and to perform fine motor tasks required in day-to-day activities. Sustaining a hand injury can be detrimental to function including the ability to work. As the literature on work-related transitions is scattered across a range of journals, it is difficult to get a sense of how much literature there is, what is known and where the gaps lie. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027402DOI Listing

Premorbid risk factors influencing labour market attachment after mild traumatic brain injury: a national register study with long-term follow-up.

BMJ Open 2019 Apr 11;9(4):e027297. Epub 2019 Apr 11.

Department of Psychology, Faculty of Social Science, University of Copenhagen, Copenhagen, Denmark.

Objectives: Some patients with mild traumatic brain injury (mTBI) experience persistent postconcussive symptoms, influencing the ability to work. This study assessed associations between mTBI and labour market attachment (up to 5 years postinjury) in patients with different premorbid characteristics.

Design And Setting: Danish national cohort study with 5-year register follow-up. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027297DOI Listing

Health system factors and caesarean sections in Kosovo: a cross-sectional study.

BMJ Open 2019 Apr 11;9(4):e026702. Epub 2019 Apr 11.

The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, New Hampshire, USA.

Objective: To investigate the association of caesarean section rates with the health system characteristics in the public hospitals of Kosovo.

Design: Cross-sectional survey.

Setting: Five largest public hospitals in Kosovo. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026702DOI Listing

Extent and determinants of catastrophic health expenditure for tuberculosis care in Chongqing municipality, China: a cross-sectional study.

BMJ Open 2019 Apr 11;9(4):e026638. Epub 2019 Apr 11.

Department of Prevention, Chongqing Institute of Tuberculosis Prevention and Treatment, Chongqing, China.

Objective: To investigate the extent and associations of patient/diagnostic delay and other potential factors with catastrophic health expenditure (CHE) for tuberculosis (TB) care in Chongqing municipality, China.

Design: A cross-sectional study.

Setting: Four counties of Chongqing municipality, China. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02663
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http://dx.doi.org/10.1136/bmjopen-2018-026638DOI Listing
April 2019
3 Reads

Epidemiological relationship between pneumonia and recurrent wheezing episode in children: an observational study at a single hospital in Korea.

BMJ Open 2019 Apr 11;9(4):e026461. Epub 2019 Apr 11.

Department of Paediatrics, College of Medicne, The Catholic University of Kora, Seoul, Republic of Korea.

Objective: This study was aimed to evaluate epidemiological and clinical relationship between (MP) infection and childhood recurrent wheezing episode (RWE).

Design: Retrospective case note review.

Setting: Paediatric department at a single Korean institution. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026461DOI Listing
April 2019
1 Read

Labour market attachment after mild traumatic brain injury: nationwide cohort study with 5-year register follow-up in Denmark.

BMJ Open 2019 Apr 11;9(4):e026104. Epub 2019 Apr 11.

Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Objectives: Sickness absence after mild traumatic brain injury (mTBI) is frequent due to postconcussive symptoms. We examined labour market attachment following mTBI up to 5 years postinjury.

Design And Setting: Nationwide cohort study with register follow-up. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026104DOI Listing
April 2019
1 Read

General practitioners' awareness of the recommendations for faecal immunochemical tests (FITs) for suspected lower gastrointestinal cancers: a national survey.

BMJ Open 2019 Apr 11;9(4):e025737. Epub 2019 Apr 11.

Research Department of Behavioural Science and Health, UCL, London, UK.

Objectives: In July 2017, UK National Institute for Health and Care Excellence (NICE) published a diagnostic guidance (DG30) recommending the use of faecal immunochemical tests (FITs) for symptomatic patients who do not meet the urgent referral pathway for suspected colorectal cancer (CRC). We assessed general practitioners' (GP) awareness of DG30 in primary care 6 months after its publication.

Design And Setting: Cross-sectional online survey of GPs hosted by an English panel of Primary health care professionals. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025737DOI Listing

Patient-centred rehabilitation for non-communicable disease in a low-resource setting: study protocol for a feasibility and proof-of-concept randomised clinical trial.

BMJ Open 2019 Apr 11;9(4):e025732. Epub 2019 Apr 11.

Department of Physiotherapy, Stellenbosch University, Cape Town, South Africa.

Introduction: Non-communicable diseases (NCDs) are the leading cause of death globally. Even though NCD disproportionally affects low-to-middle income countries, these countries including South Africa, often have limited capacity for the prevention and control of NCDs. The standard evidence-based care for the long-term management of NCDs includes rehabilitation. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02573
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http://dx.doi.org/10.1136/bmjopen-2018-025732DOI Listing
April 2019
6 Reads

Patients' and health professionals' attitudes and perceptions towards the initiation of preventive drugs for primary prevention of cardiovascular disease: protocol for a systematic review of qualitative studies.

BMJ Open 2019 Apr 11;9(4):e025587. Epub 2019 Apr 11.

Institute of Applied Health Research, University of Birmingham, Birmingham, West Midlands, UK.

Introduction: Lipid-lowering drugs and antihypertensive agents can be prescribed for the primary prevention of cardiovascular disease. In some cases, patients eligible for primary prevention of cardiovascular disease according to the European guidelines are not always started on preventive drugs. Existing research explores the attitudes of health professionals and patients towards cardiovascular preventive drugs but does not always differentiate between the attitudes towards drug initiation for primary or secondary prevention. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025587DOI Listing

Differentiating the cognitive development of early-term births in infants and toddlers: a cross-sectional study in China.

BMJ Open 2019 Apr 11;9(4):e025275. Epub 2019 Apr 11.

Psychology Division, Nottingham Trent University, Nottingham, UK.

Objectives: This study aimed to explore the cognitive development of low-risk children during early childhood for early-term births at 37 and 38 weeks of gestation compared with full term births at 39-41 weeks of gestation.

Setting And Participants: We conducted a cross-sectional study in Shanghai, one of the largest cities in China. A total of 1444 children from singleton pregnancies born at term gestation were included in the study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025275DOI Listing

Providing sex and relationships education for looked-after children: a qualitative exploration of how personal and institutional factors promote or limit the experience of role ambiguity, conflict and overload among caregivers.

BMJ Open 2019 Apr 11;9(4):e025075. Epub 2019 Apr 11.

MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.

Objectives: To explore how personal and institutional factors promote or limit caregivers promoting sexual health and relationships (SHR) among looked-after children (LAC). In so doing, develop existing research dominated by atheoretical accounts of the facilitators and barriers of SHR promotion in care settings.

Design: Qualitative semistructured interview study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025075DOI Listing

Multicentre randomised controlled trial protocol of urine CXCL10 monitoring strategy in kidney transplant recipients.

BMJ Open 2019 Apr 11;9(4):e024908. Epub 2019 Apr 11.

Internal Medicine, University of Manitoba College of Medicine, Winnipeg, Manitoba, Canada.

Introduction: Subclinical inflammation is an important predictor of death-censored graft loss, and its treatment has been shown to improve graft outcomes. Urine CXCL10 outperforms standard post-transplant surveillance in observational studies, by detecting subclinical rejection and early clinical rejection before graft functional decline in kidney transplant recipients.

Methods And Analysis: This is a phase ii/iii multicentre, international randomised controlled parallel group trial to determine if the early treatment of rejection, as detected by urine CXCL10, will improve kidney allograft outcomes. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024908DOI Listing

Gut-directed hypnotherapy versus standard medical treatment for nausea in children with functional nausea or functional dyspepsia: protocol of a multicentre randomised trial.

BMJ Open 2019 Apr 11;9(4):e024903. Epub 2019 Apr 11.

Department of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands.

Introduction: The treatment of chronic functional nausea or nausea due to functional dyspepsia in children is generally symptomatic. Moreover, these disorders pose a risk for worse psychosocial and health outcomes in children. Hypnotherapy (HT), by its ability to positively influence gastrointestinal and psychosocial functioning, may be an effective treatment for chronic nausea. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02490
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http://dx.doi.org/10.1136/bmjopen-2018-024903DOI Listing
April 2019
1 Read

What factors are associated with resilient outcomes in children exposed to social adversity? A systematic review.

BMJ Open 2019 Apr 11;9(4):e024870. Epub 2019 Apr 11.

Intergenerational Health, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

Objectives: Children exposed to social adversity-hardship as a result of social circumstances such as poverty or intergenerational trauma-are at increased risk of poor outcomes across the life course. Understanding what promotes resilient outcomes is essential for the development of evidence informed intervention strategies. We conducted a systematic review to identify how child resilience is measured and what factors are associated with resilient outcomes. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02487
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http://dx.doi.org/10.1136/bmjopen-2018-024870DOI Listing
April 2019
2 Reads

Cross-sectional study of the use of antimicrobials following common infections by rural residents in Anhui, China.

BMJ Open 2019 Apr 11;9(4):e024856. Epub 2019 Apr 11.

School of Health Services Management, Anhui Medical University, Hefei, China.

Objective: To describe help seeking behaviour from a medical doctor and antimicrobial use for common infections among rural residents of Anhui province, China.

Design: A cross-sectional retrospective household survey.

Setting: 12 administrative villages from rural Anhui, China. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02485
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http://dx.doi.org/10.1136/bmjopen-2018-024856DOI Listing
April 2019
2 Reads

Patient factors driving overuse of cardiac catheterisation: a qualitative study with 25 participants from two German teaching practices.

BMJ Open 2019 Apr 11;9(4):e024600. Epub 2019 Apr 11.

Institute for General Medicine, University Hospital Essen, Essen, Germany.

Objectives: Percutaneous coronary interventions do not provide a benefit over medical therapy for stable patients. However, an overuse of cardiac catheterisation (CC) for stable coronary artery disease (CAD) is documented in Germany and other countries. In this study, we aim to understand patient factors that foster this overuse. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024600DOI Listing

Partial versus complete prostatectomy specimen sampling: prospective non-inferiority study for pT3a tumours and surgical margin involvement.

BMJ Open 2019 Apr 11;9(4):e024524. Epub 2019 Apr 11.

Pathology, Maasstad Ziekenhuis, Rotterdam, The Netherlands.

Aims: The importance of additional information gained by complete versus partial sampling or prostatectomy specimens is uncertain. There is sparse data on the value of complete versus partial sampling and numbers of inclusions in studies are small and retrospective. We present the results of a prospective non-inferiority study to examine if partial sampling is inferior to complete sampling in terms of pathology outcomes and clinical relevance. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024524DOI Listing

The impact of general practitioners working in or alongside emergency departments: a rapid realist review.

BMJ Open 2019 Apr 11;9(4):e024501. Epub 2019 Apr 11.

Division of Population Medicine, Cardiff University, Cardiff, UK.

Objectives: Worldwide, emergency healthcare systems are under intense pressure from ever-increasing demand and evidence is urgently needed to understand how this can be safely managed. An estimated 10%-43% of emergency department patients could be treated by primary care services. In England, this has led to a policy proposal and £100 million of funding (US$130 million), for emergency departments to stream appropriate patients to a co-located primary care facility so they are 'free to care for the sickest patients'. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02450
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http://dx.doi.org/10.1136/bmjopen-2018-024501DOI Listing
April 2019
1 Read

Telemedical coaching for weight loss in overweight employees: a three-armed randomised controlled trial.

BMJ Open 2019 Apr 11;9(4):e022242. Epub 2019 Apr 11.

Occupational Health and Medical Services, Boehringer Ingelheim Pharma GmbH & Co.KG, Ingelheim am Rhein, Germany.

Objectives: We examined the effect of a telemedical coaching (TMC) programme accompanied with or without telemonitoring on weight loss in an occupational healthcare setting with a three-armed randomised controlled trial (NCT01837134 'Pre-results').

Methods: Overweight employees (n=104, body mass index [BMI] ≥25 kg/m) were invited by their medical corporate department and randomised into either a TMC group (n=34) or in one of the two control groups (C1, n=34; C2, n=36). TMC and C1 were equipped with telemonitoring devices (scales and pedometers) at baseline, and C2 after 6 months. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022242DOI Listing

Workshops on diagnosis and management of dementia for general practitioners: a pre-post intervention study of dementia knowledge.

BMJ Open 2019 Apr 9;9(4):e027804. Epub 2019 Apr 9.

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia.

Objectives: To assess improvements in dementia knowledge among general practitioner (GP) registrars and supervisors following their participation in dementia workshops.

Design: Pre-post intervention study.

Setting: General practice education in Australia. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027804DOI Listing

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people.

BMJ Open 2019 Apr 9;9(4):e027696. Epub 2019 Apr 9.

Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Objectives: Chronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the association of chronic HBV infection with total and cause-specific mortality. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027696DOI Listing
April 2019
1 Read

Breast and cervical cancer patients' experience in Addis Ababa city, Ethiopia: a follow-up study protocol.

BMJ Open 2019 Apr 9;9(4):e027034. Epub 2019 Apr 9.

Surveillance and Health Services Research, American Cancer Society, Atlanta, Georgia, USA.

Introduction: Cancer is an emerging public health problem in Ethiopia, with breast and cervical cancers accounting for over half of all newly diagnosed cancers in women. The majority of women with breast and cervical cancer are diagnosed at late stage of the disease and most patients do not receive care consistent with global standards. However, little is known about the health-seeking behaviours, barriers to early detection and treatment, patient-reported outcomes, financial burden and survival of women with breast and cervical cancer in the country. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027034DOI Listing
April 2019
1 Read

Efficacy of pressure ulcer prevention interventions in adult intensive care units: a protocol for a systematic review and network meta-analysis.

BMJ Open 2019 Apr 9;9(4):e026727. Epub 2019 Apr 9.

Heart Center, Beijing Chaoyang Hospital affiliated with Capital Medical University, Beijing, China.

Introduction: Pressure ulcers (PUs) are associated with substantial health burden. Patients in intensive care units (ICUs) are at high risk for developing PU. In the absence of large randomised controlled trials (RCTs) that compare commonly known interventions for preventing PU in ICUs, uncertainty remains around the best practice strategy for PU management in adult ICUs. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02672
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http://dx.doi.org/10.1136/bmjopen-2018-026727DOI Listing
April 2019
5 Reads

Off-label drug prescriptions in French general practice: a cross-sectional study.

BMJ Open 2019 Apr 9;9(4):e026076. Epub 2019 Apr 9.

Univ. Lyon, Université Claude Bernard Lyon 1, Université Saint-Étienne, Collège universitaire de médecine générale, F-69008 Lyon, F-42023 Saint-Étienne, Département de médecine générale, Lyon, France.

Objectives: Off-label drug prescribing is a public health and economic issue. The aim of this study was to describe off-label prescription in general practice in France, in terms of frequency and nature, and to identify its main determining factors.

Design: Multicentre cross-sectional study SETTING: Twenty-three training general practice offices PARTICIPANTS: All the voluntary patients coming for a medical consultation or visited at home over a cumulative period of 5 days per office between November 2015 and January 2016. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026076DOI Listing
April 2019
2.063 Impact Factor

What is the impact on the readmission ratio of taking into account readmissions to other hospitals? A cross-sectional study.

BMJ Open 2019 Apr 9;9(4):e025740. Epub 2019 Apr 9.

IQ healthcare, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Objectives: Readmissions are used widespread as an indicator of the quality of care within hospitals. Including readmissions to other hospitals might have consequences for hospitals. The aim of our study is to determine the impact of taking into account readmissions to other hospitals on the readmission ratio. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025740DOI Listing

A guided and unguided internet- and mobile-based intervention for chronic pain: health economic evaluation alongside a randomised controlled trial.

BMJ Open 2019 Apr 9;9(4):e023390. Epub 2019 Apr 9.

Department of Clinical Psychology and Psychotherapy, University of Ulm, Ulm, Germany.

Objective: This study aims at evaluating the cost-effectiveness and cost-utility of a guided and unguided internet-based intervention for chronic pain patients (ACTonPain and ACTonPain) compared with a waitlist control group (CG) as well as the comparative cost-effectiveness of the guided and the unguided version.

Design: This is a health economic evaluation alongside a three-arm randomised controlled trial from a societal perspective. Assessments were conducted at baseline, 9 weeks and 6 months after randomisation. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023390DOI Listing

Tailored digital behaviour change intervention with e-referral system to increase attendance at NHS stop smoking services (the MyWay project): study protocol for a randomised controlled feasibility trial.

BMJ Open 2019 Apr 8;9(4):e028721. Epub 2019 Apr 8.

Centre for Advances in Behavioural Science, Coventry University, Coventry, UK.

Introduction: In the UK, smokers who use stop smoking services (SSSs) are four times more likely to stop smoking than smokers who do not. Attendance has declined, warranting the development of interventions to address this. StopApp is a novel, brief online behaviour change intervention designed to address common barriers to SSS attendance. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028721DOI Listing

Identification of potential carcinogenic and chemopreventive effects of prescription drugs: a protocol for a Norwegian registry-based study.

BMJ Open 2019 Apr 8;9(4):e028504. Epub 2019 Apr 8.

Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.

Introduction: Surveillance of unintended effects of pharmaceuticals (pharmacovigilance or drug safety) is crucial, as knowledge of rare or late side effects is limited at the time of the introduction of new medications into the market. Side effects of drugs may involve increased or decreased risk of cancer, but these typically appear after a long induction period. This fact, together with low incidences of many cancer types, limits the usefulness of traditional pharmacovigilance strategies, primarily based on spontaneous reporting of adverse events, to identify associations between drug use and cancer risk. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028504DOI Listing

Not quite a doctor, but should I help? A qualitative exploration of medical students' attitudes towards responding to medical emergencies that occur in the public domain.

BMJ Open 2019 Apr 8;9(4):e028035. Epub 2019 Apr 8.

Research Department of Primary Care and Population Health, University College London, London, UK.

Objective: To explore medical students' views on and experiences of responding to out-of-hospital medical emergencies.

Setting: University College London (UCL).

Participants: 11 UCL Medical School students. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028035DOI Listing

Asylum seekers health and wellbeing (TERTTU) survey: study protocol for a prospective total population health examination survey on the health and service needs of newly arrived asylum seekers in Finland.

BMJ Open 2019 Apr 8;9(4):e027917. Epub 2019 Apr 8.

Department of Welfare, National Institute for Health and Welfare, Helsinki, Finland.

Introduction: Health, well-being and health service needs of asylum seekers have emerged as urgent topics following the arrival of 2.5 million asylum seekers to the European Union (EU) between 2015 and 2016. However, representative information on the health, well-being and service needs of asylum seekers is scarce. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027917DOI Listing