297 results match your criteria BMJ evidence-based medicine[Journal]


Efficacy of reminders for increasing volunteer engagement in translating Cochrane plain language summaries: a pilot randomised controlled trial.

BMJ Evid Based Med 2020 Jul 7. Epub 2020 Jul 7.

Croatian Catholic University, Zagreb, Croatia

Objectives: The aim of this study was to pilot test the effectiveness of reminders versus no intervention for increasing the number of translated Cochrane plain language summaries (PLSs) among volunteer translators.

Study Design: Parallel-group randomised controlled trial.

Setting: Cochrane Croatia translation project. Read More

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http://dx.doi.org/10.1136/bmjebm-2020-111378DOI Listing

Dietary Recommendations for Familial Hypercholesterolaemia: an Evidence-Free Zone.

BMJ Evid Based Med 2020 Jul 5. Epub 2020 Jul 5.

Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA.

We have evaluated dietary recommendations for people diagnosed with familial hypercholesterolaemia (FH), a genetic condition in which increased low-density lipoprotein cholesterol (LDL-C) is associated with an increased risk for coronary heart disease (CHD). Recommendations for FH individuals have emphasised a low saturated fat, low cholesterol diet to reduce their LDL-C levels. The basis of this recommendation is the 'diet-heart hypothesis', which postulates that consumption of food rich in saturated fat increases serum cholesterol levels, which increases risk of CHD. Read More

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http://dx.doi.org/10.1136/bmjebm-2020-111412DOI Listing

Evaluation of the completeness of intervention reporting in Cochrane surgical systematic reviews using the TIDieR-SR checklist: a cross-sectional study.

BMJ Evid Based Med 2020 Jun 23. Epub 2020 Jun 23.

Psychiatry and Behavioral Sciences, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, USA

Introduction: Complete reporting of systematic reviews of interventions is essential to the interpretation of research findings and the reproducibility of research results. The Template for Intervention Description and Replication (TIDieR) checklist-and the version specific to systematic reviews (TIDieR-SR)-was created to provide authors and researchers an evidence-based guide for reporting trial and systematic review interventions. In this study, we apply TIDieR-SR to Cochrane systematic reviews of surgical interventions. Read More

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http://dx.doi.org/10.1136/bmjebm-2020-111417DOI Listing

Temperature and COVID-19: India.

Authors:
Manas Pratim Roy

BMJ Evid Based Med 2020 Jun 17. Epub 2020 Jun 17.

Ministry of Health and Family Welfare, New Delhi, India

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http://dx.doi.org/10.1136/bmjebm-2020-111459DOI Listing

EBM in Brazil and the creation of the Oxford-Brazil EBM Alliance.

BMJ Evid Based Med 2020 Jun 18. Epub 2020 Jun 18.

Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2020-111377DOI Listing

Does taking omega-3 supplements reduce the risk of having depression or anxiety? Probably not.

Authors:
Igho Onakpoya

BMJ Evid Based Med 2020 Jun 16. Epub 2020 Jun 16.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

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http://dx.doi.org/10.1136/bmjebm-2020-111341DOI Listing

Evaluating the quality of systematic reviews and meta-analyses published on direct oral anticoagulants in the past 5 years.

BMJ Evid Based Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Systematic reviews (SRs) have been reported with increasing frequency as a means of collating studies which may have been performed over different period of times, in different geographical areas and by different groups of investigators. As SRs have become more common, quality metrics such as Assessing the Methodological Quality of Systematic Reviews (AMSTAR) have become available for these reviews. AMSTAR is an 11-point checklist that assesses the methodological and reporting quality of a SR. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111326DOI Listing

COVID-19 and the US response: accelerating health inequities.

BMJ Evid Based Med 2020 Jun 3. Epub 2020 Jun 3.

Center for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Health inequities have long defined health and the healthcare system in the USA. The clinical and research capacity across the USA is unparalleled, yet compared to other high and even some middle-income countries, the average health indicators of the population remain suboptimal in 2020, a finding at least in part explained by inequity in healthcare access. In this context, COVID-19 has rapidly emerged as a major threat to the public's health. Read More

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http://dx.doi.org/10.1136/bmjebm-2020-111426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299650PMC

Should clinical practice change to bedtime administration of antihypertensive?

Authors:
Jian-Yu E

BMJ Evid Based Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA

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http://dx.doi.org/10.1136/bmjebm-2020-111435DOI Listing

Alcohol and atrial fibrillation: to or not to drink?

BMJ Evid Based Med 2020 Jun 3. Epub 2020 Jun 3.

Division of Cardiology, Department of Medicine, Stanford University, Stanford, California, USA

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http://dx.doi.org/10.1136/bmjebm-2020-111340DOI Listing

Should patients with atrial fibrillation and stable coronary artery disease receive an oral anticoagulant, an antiplatelet or both?

Authors:
Mark T Mills

BMJ Evid Based Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

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http://dx.doi.org/10.1136/bmjebm-2020-111376DOI Listing

Problem with patient decision aids.

BMJ Evid Based Med 2020 May 21. Epub 2020 May 21.

Institute for Musculoskeletal Health, Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

Patient decision aids are evidence-based tools designed to help patients make specific and deliberated choices among healthcare options. Research shows that patient decision aids increase knowledge, accuracy of risk perceptions, alignment of care with patient values and preferences, and patient involvement in decision making. Some patient decision aids can reduce the use of invasive and potentially low-value procedures. Read More

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http://dx.doi.org/10.1136/bmjebm-2020-111371DOI Listing

Thrombolysis with alteplase 3-4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances.

BMJ Evid Based Med 2020 May 19. Epub 2020 May 19.

Innovations and Evidence-Based Medicine Development, EBSCO Health, Ipswich, Massachusetts, USA.

Objectives: Alteplase is commonly recommended for acute ischaemic stroke within 4.5 hours after stroke onset. The Third European Cooperative Acute Stroke Study (ECASS III) is the only trial reporting statistically significant efficacy for clinical outcomes for alteplase use 3-4. Read More

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http://dx.doi.org/10.1136/bmjebm-2020-111386DOI Listing

Epinephrine should continue to be used in the treatment of out-of-hospital cardiac arrest.

BMJ Evid Based Med 2020 May 12. Epub 2020 May 12.

Emergency Department, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK

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http://dx.doi.org/10.1136/bmjebm-2019-111318DOI Listing

Methylphenidate for ADHD rejected from the WHO Essential Medicines List due to uncertainties in benefit-harm profile.

BMJ Evid Based Med 2020 Apr 24. Epub 2020 Apr 24.

The Copenhagen Trial Unit (CTU), Centre for Clinical Intervention Research, Copenhagen, Denmark.

Attention deficit hyperactivity disorder (ADHD) is a common psychiatric disorder with estimated global prevalence rates between 3% and 5% in children and 2.5% in adults, depending on the classification system used. The psychostimulant methylphenidate is one of the most frequently used medications for ADHD. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111328DOI Listing

How should we manage hip fracture patients on direct oral anticoagulants?

BMJ Evid Based Med 2020 Apr 24. Epub 2020 Apr 24.

Trauma and Orthopaedics, Leicester General Hospital, Leicester, Leicester, UK.

Objective: Currently, there are no national protocols in place for managing hip fracture patients on direct oral anticoagulants (DOACs). Hence, various local management protocols exist. We compared three different local protocols and a control group to assess blood loss and time delay to theatre. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111317DOI Listing

Tranexamic acid in acute traumatic brain injury.

BMJ Evid Based Med 2020 Apr 21. Epub 2020 Apr 21.

Emergency Department, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK

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http://dx.doi.org/10.1136/bmjebm-2019-111319DOI Listing

Correction: .

Authors:

BMJ Evid Based Med 2020 06 14;25(3):e3. Epub 2020 Apr 14.

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http://dx.doi.org/10.1136/bmjebm-2018-111012corr1DOI Listing

Editors' Note: .

Authors:

BMJ Evid Based Med 2020 06 9;25(3):e2. Epub 2020 Apr 9.

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http://dx.doi.org/10.1136/bmjebm-2018-111012ednoteDOI Listing

Multidisciplinary teams effect on major amputations in patients with diabetes.

BMJ Evid Based Med 2020 Mar 31. Epub 2020 Mar 31.

Centre for Evidece-Based Medicne, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2020-111342DOI Listing

Improving the transparency of meta-analyses with interactive web applications.

BMJ Evid Based Med 2020 Mar 27. Epub 2020 Mar 27.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Increased transparency in study design and analysis is one proposed solution to the perceived reproducibility crisis facing science. Systematic review and meta-analysis-through which individual studies on a specific association are ascertained, assessed for quality and quantitatively combined-is a critical process for building consensus in medical research. However, the conventional publication model creates static evidence summaries that force the quality assessment criteria and analytical choices of a small number of authors onto all stakeholders, some of whom will have different views on the quality assessment and key features of the analysis. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111308DOI Listing

Big data registries in spine surgery research: the lurking dangers.

BMJ Evid Based Med 2020 Mar 22. Epub 2020 Mar 22.

Division of Neurosurgery, Ascension Providence Hospital, Michigan State University, College of Human Medicine, Southfield, Michigan, USA.

Spine surgery research has improved considerably over the last few decades. Its' most recent growth is in large part due to the mounting increase in studies conducted using national databases and registries. With easy access to a large number of patients, the benefit of these registries has become evident. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111333DOI Listing

Efficacy and effectiveness studies of depression are not well-differentiated in the literature: a systematic review.

BMJ Evid Based Med 2020 Mar 18. Epub 2020 Mar 18.

Institute of Clinical Economics, Ulm, Germany.

Background: In the literature on the treatment of depression, efficacy and effectiveness research have different purposes and should apply different research methodologies.

Objective: The purpose of the study was to review characteristics of depression treatment studies identified using efficacy or effectiveness search terms. We considered subject inclusion and exclusion criteria; numbers of subjects enrolled and the proportion in the primary analyses; inclusion of a Consolidated Standards of Reporting Trials (CONSORT) flow diagram; use of random assignment; use of placebo control conditions; lengths of treatment and follow-up; primary outcome variable; trial registration; journal impact factor. Read More

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http://dx.doi.org/10.1136/bmjebm-2020-111337DOI Listing

Adjuvant-containing control arms in pivotal quadrivalent human papillomavirus vaccine trials: restoration of previously unpublished methodology.

BMJ Evid Based Med 2020 Mar 17. Epub 2020 Mar 17.

Centre for Evidence-Based Medicine, University of Oxford, Oxford, UK.

Purpose: Trustworthy reporting of quadrivalent human papillomavirus (HPV) vaccine trials is the foundation for assessing the vaccine's risks and benefits. However, several pivotal trial publications incompletely reported important methodological details and inaccurately described the formulation that the control arms received. Under the Restoring Invisible and Abandoned Trials initiative (RIAT), we aim to restore the public record regarding the content and rationale of the controls used in the trials. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111331DOI Listing

When is the right time to induce labour?

BMJ Evid Based Med 2020 Mar 17. Epub 2020 Mar 17.

METRICS at Stanford, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1136/bmjebm-2019-111330DOI Listing

Intervention reporting of clinical trials published in high-impact cardiology journals: effect of the TIDieR checklist and guide.

BMJ Evid Based Med 2020 Mar 5. Epub 2020 Mar 5.

Department of Psychiatry and Behavioral Science, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, USA.

Background: Randomised controlled trials (RCTs) provide the highest-level of evidence among primary research in cardiovascular medicine. Yet, even the best trial may be less useful if it fails to provide an accurate means of reproducibility. Unfortunately, discrepancies in the standards of trial reporting have been persistent in previous trials. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111309DOI Listing

Ibuprofen for acute pain relief in the emergency department.

Authors:
Dylan Collins

BMJ Evid Based Med 2020 Mar 3. Epub 2020 Mar 3.

Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1136/bmjebm-2019-111312DOI Listing

Upholding trust in therapeutic trials and evidence-based medicine: need for full disclosure of data, crowdsourcing data analysis and independent review?

BMJ Evid Based Med 2020 Feb 26. Epub 2020 Feb 26.

Department of Cardiology, Tulane University School of Medicine; Tulane University Heart and Vascular Institute, New Orleans, Louisiana, USA.

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http://dx.doi.org/10.1136/bmjebm-2019-111242DOI Listing
February 2020

Statins for primary prevention: what is the regulator's role?

BMJ Evid Based Med 2020 Feb 26. Epub 2020 Feb 26.

Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.

Globally, drug regulators have approved statins for the prevention of cardiovascular disease (CVD), although their use in primary prevention has been controversial. A highly publicised debate has ensued over whether the benefits outweigh the harms. Drug regulators, which are legally required to make independent judgements on drug approvals, have remained silent during the debate. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111321DOI Listing
February 2020

Short course penicillin for treating patients with pharyngotonsillitis.

BMJ Evid Based Med 2020 Feb 25. Epub 2020 Feb 25.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2019-111314DOI Listing
February 2020

Systematic benefit-risk assessment for buprenorphine implant: a semiquantitative method to support risk management.

BMJ Evid Based Med 2020 Feb 24. Epub 2020 Feb 24.

Drug Safety Research Unit, Southampton, UK.

Background: Prior to approval in the European Union, a systematic benefit-risk assessment was required to compare buprenorphine implant to sublingual buprenorphine as part of the license application to the European Medicines Agency.

Objective: The Benefit-Risk Action Team framework was used to describe the overall benefit-risk of buprenorphine implant in comparison to sublingual buprenorphine.

Study Selection/methods: A value tree of key benefits and risks related to the implant formulation of buprenorphine was constructed. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111295DOI Listing
February 2020

How to reduce diagnostic error: 'neutral zone' approach.

BMJ Evid Based Med 2020 Feb 18. Epub 2020 Feb 18.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2019-111324DOI Listing
February 2020

Best timing of tranexamic acid administration for bleeding after trauma or childbirth remains to be established.

BMJ Evid Based Med 2020 Feb 13. Epub 2020 Feb 13.

Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/bmjebm-2019-111290DOI Listing
February 2020

Does the PROSPERO registration prevent double review on the same topic?

BMJ Evid Based Med 2020 Feb 13. Epub 2020 Feb 13.

Lenval Foundation, Nice, France.

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http://dx.doi.org/10.1136/bmjebm-2020-111361DOI Listing
February 2020

Does ursodeoxycholic acid have a role in the treatment of women with intrahepatic (obstetric) cholestasis of pregnancy anymore?

BMJ Evid Based Med 2020 Feb 11. Epub 2020 Feb 11.

Obstetrics and Gynaecology, Queen's Medical Centre Nottingham University Hospital NHS Trust, Nottingham, UK

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http://dx.doi.org/10.1136/bmjebm-2019-111292DOI Listing
February 2020

Characteristics and conflicts of interests of public speakers at the Psychopharmacologic Drug and Advisory Committee meetings regarding psychiatric drugs.

BMJ Evid Based Med 2020 Feb 4. Epub 2020 Feb 4.

Research, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, USA.

The Psychopharmacologic Drug Advisory Committee (PDAC) is one of 33 advisory committees of the Food and Drug Administration (FDA). During committee meetings, an open public hearing takes place where speakers provide testimonies about the drug in question and are asked, not required, to disclose any conflicts of interests (COIs) before speaking. These speakers may present with COIs which include, but are not limited to, reimbursement for travel and lodging by the pharmaceutical company to attend the meeting; previous or current payments for consulting from the pharmaceutical company and compensation as a paid investigator in previously conducted clinical trials for the drug under review. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111299DOI Listing
February 2020

Antipsychotics for preventing and treating delirium: not recommended.

BMJ Evid Based Med 2020 Feb 3. Epub 2020 Feb 3.

School of Medicine, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1136/bmjebm-2019-111293DOI Listing
February 2020

Should blood pressure medications be taken at bedtime?

BMJ Evid Based Med 2020 Jan 28. Epub 2020 Jan 28.

Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2019-111311DOI Listing
January 2020

Assessment of assumptions of statistical analysis methods in randomised clinical trials: the what and how.

BMJ Evid Based Med 2020 Jan 27. Epub 2020 Jan 27.

Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

When analysing and presenting results of randomised clinical trials, trialists rarely report if or how underlying statistical assumptions were validated. To avoid data-driven biased trial results, it should be common practice to prospectively describe the assessments of underlying assumptions. In existing literature, there is no consensus on how trialists should assess and report underlying assumptions for the analyses of randomised clinical trials. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111268DOI Listing
January 2020

Limited engagement with transparent and open science standards in the policies of pain journals: a cross-sectional evaluation.

BMJ Evid Based Med 2020 Jan 24. Epub 2020 Jan 24.

Centre for Statistics in Medicine & Rehabilitation Research in Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, Oxfordshire, UK.

Scientific progress requires transparency and openness. The ability to critique, replicate and implement scientific findings depends on the transparency of the study design and methods, and the open availability of study materials, data and code. Journals are key stakeholders in supporting transparency and openness. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111296DOI Listing
January 2020

Association of serum magnesium level change with in-hospital mortality.

BMJ Evid Based Med 2020 Jan 24. Epub 2020 Jan 24.

Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

The objective of this study was to assess the association of in-hospital mortality risk based on change in serum magnesium levels in hospitalised patients. All adult patients admitted to our hospital from years 2009 to 2013 with at least two serum magnesium measurements during hospitalisation were included. Serum magnesium change, defined as the absolute difference between the highest and lowest serum magnesium, was categorised into six groups: 0-0. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111322DOI Listing
January 2020

Forgotten Primodos story and the roles of general practitioners.

BMJ Evid Based Med 2020 Jan 23. Epub 2020 Jan 23.

Centre for Evidence-Based Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2019-111307DOI Listing
January 2020

A year in statistics-the view from the trenches.

BMJ Evid Based Med 2020 06 7;25(3):81-82. Epub 2020 Jan 7.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2019-111303DOI Listing

Claims of 'no difference' or 'no effect' in Cochrane and other systematic reviews.

BMJ Evid Based Med 2020 Jan 7. Epub 2020 Jan 7.

Centre for Evidenced-Based Medicine, University of Oxford, Oxford, Oxfordshire, UK.

Estimates of treatment effects/differences derived from controlled comparisons are subject to uncertainty, both because of the quality of the data and the play of chance. Despite this, authors sometimes use statistical significance testing to make definitive statements that 'no difference exists between' treatments. A survey to assess abstracts of Cochrane reviews published in 2001/2002 identified unqualified claims of 'no difference' or 'no effect' in 259 (21. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111257DOI Listing
January 2020

Metoprolol is not effective for preventing acute exacerbations in COPD.

Authors:
Igho J Onakpoya

BMJ Evid Based Med 2020 Jan 7. Epub 2020 Jan 7.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

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http://dx.doi.org/10.1136/bmjebm-2019-111313DOI Listing
January 2020

The need for clinical judgement in the application of evidence-based medicine.

Authors:
J David Spence

BMJ Evid Based Med 2019 Dec 5. Epub 2019 Dec 5.

Stroke Prevention and Atherosclerosis Research Centre, 1400 Western Road, London, ON N6G 2V4, Canada

Background: Evidence-based medicine (EBM) has no doubt resulted in great improvements in the practice of medicine. However, there are problems with overly zealous application of EBM, that for some amounts to religious practice. When good evidence exists, it should guide therapeutic and diagnostic choices. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111300DOI Listing
December 2019

Performing baseline testing in cluster randomised controlled trials.

BMJ Evid Based Med 2019 Dec 3. Epub 2019 Dec 3.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

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http://dx.doi.org/10.1136/bmjebm-2019-111283DOI Listing
December 2019

HOSPITAL Score, LACE Index and LACE+ Index as predictors of 30-day readmission in patients with heart failure.

BMJ Evid Based Med 2019 Nov 26. Epub 2019 Nov 26.

Internal Medicine, SIU School of Medicine, Springfield, Illinois, USA.

This study aimed to evaluate the accuracy of the HOSPITAL Score (Haemoglobin level at discharge, Oncology at discharge, Sodium level at discharge, Procedure during hospitalization, Index admission, number of hospital admissions, Length of stay) LACE index (Length of stay, Acute/emergent admission, Charlson comorbidy index score, Emerency department visits in previous 6 months) and LACE+ index in predicting 30-day readmission in patients with diastolic dysfunction. Heart failure remains one of the most common hospital readmissions in adults, leading to significant morbidity and mortality. Different models have been used to predict 30-day hospital readmissions. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111271DOI Listing
November 2019