178 results match your criteria BMJ evidence-based medicine[Journal]


Guidelines do not self-implement: time for a research paradigm shift from massive creation to effective implementation in evidence-based medicine research in China.

BMJ Evid Based Med 2019 Apr 13. Epub 2019 Apr 13.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

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http://ebm.bmj.com/lookup/doi/10.1136/bmjebm-2019-111193
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http://dx.doi.org/10.1136/bmjebm-2019-111193DOI Listing
April 2019
5 Reads

Contemporary communication in a clinical trial.

BMJ Evid Based Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Plastic Surgery, Stoke Mandeville Hospital, Aylesbury, UK.

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http://dx.doi.org/10.1136/bmjebm-2019-111196DOI Listing

Is there a genuine placebo effect in acute depression treatments? A reassessment of regression to the mean and spontaneous remission.

BMJ Evid Based Med 2019 Apr 11. Epub 2019 Apr 11.

Regression to the mean and spontaneous improvements are rarely considered in interpretations of treatment trials for acute major depression. Here I suggest that regression to the mean and spontaneous remission may account for most improvements seen in placebo groups and also for a large proportion of variance in the acute treatment outcome of both antidepressant pharmacotherapy and psychotherapy. These findings have important implications for the interpretation of active treatments and placebo response in depression trials. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111161DOI Listing
April 2019
1 Read

Network meta-analysis for diagnostic tests.

BMJ Evid Based Med 2019 Apr 11. Epub 2019 Apr 11.

Division of Cardiovascular Medicine and Cardiovascular Institute, Department of Medicine, Stanford University, Stanford, California, USA, Stanford University, Palo Alto, California, USA.

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http://ebm.bmj.com/lookup/doi/10.1136/bmjebm-2019-111179
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http://dx.doi.org/10.1136/bmjebm-2019-111179DOI Listing
April 2019
1 Read

Cochrane authors on drug industry payroll should not be allowed.

BMJ Evid Based Med 2019 Apr 11. Epub 2019 Apr 11.

Institute of Scientific Freedom, Copenhagen, Denmark.

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http://ebm.bmj.com/lookup/doi/10.1136/bmjebm-2018-111124
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http://dx.doi.org/10.1136/bmjebm-2018-111124DOI Listing
April 2019
1 Read

EBM verdict: should albendazole be used for treating lymphatic filariasis? No.

Authors:
Igho J Onakpoya

BMJ Evid Based Med 2019 Apr 10. Epub 2019 Apr 10.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, Oxfordshire, UK.

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http://dx.doi.org/10.1136/bmjebm-2019-111184DOI Listing

Assessing assumptions for statistical analyses in randomised clinical trials.

BMJ Evid Based Med 2019 Apr 4. Epub 2019 Apr 4.

Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Kobenhavn, Denmark.

In order to ensure the validity of results of randomised clinical trials and under some circumstances to optimise statistical power, most statistical methods require validation of underlying statistical assumptions. The present paper describes how trialists in major medical journals report tests of underlying statistical assumptions when analysing results of randomised clinical trials. We also consider possible solutions how to improve current practice by adequate reporting of tests of underlying statistical assumptions. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111174DOI Listing
April 2019
1 Read

Vitamin D does not prevent fractures and falls.

BMJ Evid Based Med 2019 Apr 3. Epub 2019 Apr 3.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2018-111129DOI Listing

Institute for Scientific Freedom.

BMJ Evid Based Med 2019 Mar 27. Epub 2019 Mar 27.

Institute for Scientific Freedom, Copenhagen, Denmark.

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http://dx.doi.org/10.1136/bmjebm-2019-111185DOI Listing

Evaluation of the NCCN guidelines using the RIGHT Statement and AGREE-II instrument: a cross-sectional review.

BMJ Evid Based Med 2019 Mar 23. Epub 2019 Mar 23.

Psychiatry and Behavioral Sciences, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

Introduction: Robust, clearly reported clinical practice guidelines (CPGs) are essential for evidence-based clinical practice. The Reporting Items for practice Guidelines in HealThcare (RIGHT) Statement and Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument were published to improve the methodological and reporting quality in healthcare CPGs.

Methods: We applied the RIGHT Statement checklist and AGREE-II instrument to 48 National Comprehensive Cancer Network (NCCN) guidelines. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111153DOI Listing

Commitments by the biopharmaceutical industry to clinical trial transparency: the evolving environment.

BMJ Evid Based Med 2019 Mar 21. Epub 2019 Mar 21.

Oxford PharmaGenesis Ltd, Tubney, UK.

Clinical trial sponsors have ethical obligations to register protocols, report study results and comply with applicable legal requirements. To evaluate public commitments to trial disclosure and rates of disclosure by members and non-members of the European Federation of Pharmaceutical Industries and Associations (EFPIA) and/or the Pharmaceutical Research and Manufacturers of America (PhRMA). Websites of the top 50 biopharmaceutical companies by 2015 sales were searched for statements relating to trial data disclosure. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111145DOI Listing

Critical appraisal of qualitative research: necessity, partialities and the issue of bias.

BMJ Evid Based Med 2019 Mar 12. Epub 2019 Mar 12.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2018-111132DOI Listing

Cochrane vertebroplasty review misrepresented evidence for vertebroplasty with early intervention in severely affected patients.

BMJ Evid Based Med 2019 Mar 9. Epub 2019 Mar 9.

Department of Biostatistics, Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.

The Cochrane vertebroplasty review of April 2018 was replaced with an updated version in November 2018 to address complaints of errors in analysis. The updated version continues to misrepresent the evidence supporting early intervention with vertebroplasty for patients with uncontrolled, severe pain and fracture duration <6 weeks. The VAPOUR trial is the only blinded trial of vertebroplasty restricted to this patient group. Read More

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http://dx.doi.org/10.1136/bmjebm-2019-111171DOI Listing

Qualitative research as evidence: expanding the paradigm for evidence-based healthcare.

BMJ Evid Based Med 2019 Mar 8. Epub 2019 Mar 8.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2018-111131DOI Listing

Perfect Top of the Evidence Hierarchy Pyramid, Maybe Not So Perfect: lessons learned by a novice researcher engaging in a meta-analysis project.

Authors:
Maranda Herner

BMJ Evid Based Med 2019 Mar 6. Epub 2019 Mar 6.

School of Medicine Internal Medicine Program, University of Colorado, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1136/bmjebm-2018-111141DOI Listing

Continuous outcome measures: conundrums and conversions contributing to clinical application.

Authors:
Martin Mayer

BMJ Evid Based Med 2019 Mar 5. Epub 2019 Mar 5.

Innovations and Evidence-Based Medicine Development, EBSCO Health|EBSCO Information Services, Ipswich, Massachusetts, USA.

Many patient-relevant outcomes, particularly quality of life measures such as pain or function, are routinely measured on a continuous scale. However, the interpretation of continuous outcomes is difficult, particularly when considering application to clinical practice and shared decision-making. Making matters worse is the frequent existence of multiple scales for any given construct. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111136DOI Listing
March 2019
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Righteous indignation versus misplaced frustration: p values, CIs, effect sizes and the CASTLE-AF trial.

Authors:
Martin Mayer

BMJ Evid Based Med 2019 Feb 27. Epub 2019 Feb 27.

Innovations and Evidence-Based Medicine Development, EBSCO Health|EBSCO Information Services, Ipswich, Massachusetts, USA.

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http://dx.doi.org/10.1136/bmjebm-2019-111178DOI Listing
February 2019

Make quotations great again: a proposal to reduce false-knowledge.

BMJ Evid Based Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Family Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

The last decades saw remarkable change in the way healthcare professionals generate and consume medical knowledge. Information management technologies have evolved considerably, yet medical publications continue to use a referencing system that has changed very little since the turn of the 20th century. Research suggests that up to one in five referenced claims quotes the original text inaccurately. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111109DOI Listing
February 2019

Can drinking more water prevent urinary tract infections? The evidence says yes.

BMJ Evid Based Med 2019 Feb 20. Epub 2019 Feb 20.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2018-111143DOI Listing
February 2019

Evidence maps: a tool to guide research agenda setting.

BMJ Evid Based Med 2019 Feb 18. Epub 2019 Feb 18.

Department of Preventive Medicine, Mayo Clinic, Rochester, Minnesota, USA.

A surprisingly huge proportion of medical research still shows poor quality in design, conduct and analysis, leading to far from optimal robustness of findings and validity of conclusions. Research waste remains a problem caused by a number of reasons. Asking the wrong research questions and ignoring the existing evidence are possible preventable ones. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111137DOI Listing
February 2019

Causal inference for clinicians.

BMJ Evid Based Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Epidemiology, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.

Evidence-based medicine (EBM) calls on clinicians to incorporate the 'best available evidence' into clinical decision-making. For decisions regarding treatment, the best evidence is that which determines the causal effect of treatments on the clinical outcomes of interest. Unfortunately, research often provides evidence where associations are not due to cause-and-effect, but rather due to non-causal reasons. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111069DOI Listing
February 2019

Determinants of inter-practice variation in ADHD diagnosis and stimulant prescribing: cross-sectional database study of a national surveillance network.

BMJ Evid Based Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical and Experimental medicine, University of Surrey, Guildford, UK.

Early recognition, identification and treatment of children with attention deficit hyperactivity disorder (ADHD) can reduce detrimental outcomes and redirect their developmental trajectory. We aimed to describe variations in age of ADHD diagnosis and stimulant prescribing among general practitioner practices in a nationwide network and identify child, parental, household and general practice factors that might account for these variations. Cross-sectional study of children aged under 19 years registered within a general practice in the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) network in 2016, RCGP RSC has a household key allowing parent and child details to be linked. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111133DOI Listing
February 2019
1 Read

Conducting one-stage IPD meta-analysis: which approach should I choose?

BMJ Evid Based Med 2019 Feb 12. Epub 2019 Feb 12.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2018-111127DOI Listing
February 2019

Overdiagnosis paradigm: not suitable for decreasing the overuse of antibiotics.

BMJ Evid Based Med 2019 Feb 11. Epub 2019 Feb 11.

Center for Research and Education in General Practice, Institute of Public health, University of Copenhagen, Copenhagen, Denmark.

This paper summarises the discussion during the workshop on 'Overdiagnosis and overtreatment of infectious diseases in general practice. How and where to break the endless loop?' The workshop was organised as part of the overdiagnosis conference carried out in August 2018 in Copenhagen, Denmark. During the workshop, participants from all over the world reflected on the challenges of embracing the overdiagnosis paradigm as a tool to advance understanding and to find solutions to the unnecessary use of antibiotics in primary health care. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111146DOI Listing
February 2019
12 Reads

Use of modified intention-to-treat analysis in studies of direct oral anticoagulants and risk of selection bias: a systematic review.

BMJ Evid Based Med 2019 Apr 11;24(2):63-69. Epub 2019 Feb 11.

Internal Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

Background: Following their evaluation in randomised controlled trials (RCTs), direct oral anticoagulants (DOACs) have replaced warfarin for stroke prevention in atrial fibrillation (AF), and treatment and prevention of venous thromboembolism (VTE). To avoid selection bias, it is recommended that RCTs use an intention-to-treat (ITT) analysis strategy.

Objective: The objective of this study was to systematically review and compare reported analytical strategies, the proportion of randomised patients included in analyses and the reasons for participant exclusions. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111057DOI Listing
April 2019
3 Reads

Aspirin for the primary prevention of cardiovascular disease in the elderly.

BMJ Evid Based Med 2019 Feb 6. Epub 2019 Feb 6.

Division of Cardiology, Department of Medicine, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1136/bmjebm-2018-111138DOI Listing
February 2019

Lorcaserin in obesity: minimal benefits and ill-defined harms.

BMJ Evid Based Med 2019 Jan 30. Epub 2019 Jan 30.

Centre for Evidence Based Medicine, University of Oxford, Oxford, UK.

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http://ebm.bmj.com/lookup/doi/10.1136/bmjebm-2018-111128
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http://dx.doi.org/10.1136/bmjebm-2018-111128DOI Listing
January 2019
8 Reads

Introducing the EBM Verdict: research evidence relevant to clinical practice.

BMJ Evid Based Med 2019 Jan 30. Epub 2019 Jan 30.

Nuffield Department of Primary Care Health Sciences, Centre for Evidence Based Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2019-111172DOI Listing
January 2019

BMJ Evidence-Based Medicine in 2018.

Authors:
Carl Heneghan

BMJ Evid Based Med 2019 04 29;24(2):43-44. Epub 2019 Jan 29.

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http://dx.doi.org/10.1136/bmjebm-2018-111155DOI Listing

Ongoing inadequacy of quadrivalent HPV vaccine safety studies.

BMJ Evid Based Med 2019 Jan 7. Epub 2019 Jan 7.

Rural Clinical School, University of New South Wales, Coffs Harbour, New South Wales, Australia.

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http://dx.doi.org/10.1136/bmjebm-2018-111122DOI Listing
January 2019

Is there a prospect for mass drug administration of azithromycin to reduce child mortality in sub-Saharan Africa?

Authors:
Agbessi Amouzou

BMJ Evid Based Med 2019 Jan 3. Epub 2019 Jan 3.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1136/bmjebm-2018-111135DOI Listing
January 2019

Clinicians' cognitive biases: a potential barrier to implementation of evidence-based clinical practice.

BMJ Evid Based Med 2018 Dec 28. Epub 2018 Dec 28.

Division of Health Care Policy and Research, Robert D and Patricia E Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1136/bmjebm-2018-111074DOI Listing
December 2018
1 Read

Inclusion and exclusion criteria and the problem of describing homogeneity of study populations in clinical trials.

BMJ Evid Based Med 2018 Dec 19. Epub 2018 Dec 19.

College of Business, Kutztown University, Kutztown, Pennsylvania, USA.

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http://ebm.bmj.com/lookup/doi/10.1136/bmjebm-2018-111115
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http://dx.doi.org/10.1136/bmjebm-2018-111115DOI Listing
December 2018
5 Reads

Drug discovery today: no molecules required.

BMJ Evid Based Med 2019 Apr 6;24(2):48-52. Epub 2018 Dec 6.

Vancouver Prostate Centre, Department of Urologic Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1136/bmjebm-2018-111121DOI Listing
April 2019
5 Reads

Catalogue of bias: publication bias.

BMJ Evid Based Med 2019 Apr 6;24(2):53-54. Epub 2018 Dec 6.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/bmjebm-2018-111107DOI Listing
April 2019
1 Read

A cross-sectional study to assess Evidence-Based Medicine teaching method: online or face-to-face?

BMJ Evid Based Med 2019 Apr 11;24(2):59-62. Epub 2018 Dec 11.

Department of Critical Care Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

We aimed to study differences in postgraduate students' achievement if they are taught evidence-based medicine (EBM) by face-to-face or by online learning. We assessed the performance of 28 postgraduate students who completed a face-to-face learning module and 34 students who completed an online learning module in a cross-sectional study. The teaching materials were the same in both courses so that any performance difference would be due to the teaching method. Read More

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http://dx.doi.org/10.1136/bmjebm-2018-111117DOI Listing
April 2019
2 Reads

Updated 2018 NICE guideline on pharmacological treatments for people with ADHD: a critical look.

BMJ Evid Based Med 2018 Dec 10. Epub 2018 Dec 10.

Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark.

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http://dx.doi.org/10.1136/bmjebm-2018-111110DOI Listing
December 2018
1 Read

Pivmecillinam is more effective than ibuprofen in symptom resolution in women with uncomplicated urinary tract infection: antibiotic treatment for UTI is important.

Authors:
Jutta Bleidorn

BMJ Evid Based Med 2018 Dec 5. Epub 2018 Dec 5.

Department of General Practice, Medical School Hannover, Hannover, Germany.

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http://dx.doi.org/10.1136/bmjebm-2018-111084DOI Listing
December 2018

Optimal anticoagulant treatment of cancer-associated venous thromboembolism remains unclear.

Authors:
Hanny Al-Samkari

BMJ Evid Based Med 2018 Dec 5. Epub 2018 Dec 5.

Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/bmjebm-2018-111096DOI Listing
December 2018

Single-dose fosfomycin is less effective than 5-day nitrofurantoin in women with uncomplicated urinary tract infection: closing the evidence gap for a new recommendation of an old antibiotic.

Authors:
Ildikó Gágyor

BMJ Evid Based Med 2018 Dec 5. Epub 2018 Dec 5.

Department for General Practice, Julius-Maximilians-Universitat Wurzburg, Wurzburg, Germany.

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http://dx.doi.org/10.1136/bmjebm-2018-111063DOI Listing
December 2018

Evidence-based management as a basis for evidence-based medical consultation.

BMJ Evid Based Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Health Economics, Iranian Center of Excellence in Health Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1136/bmjebm-2018-111104DOI Listing
November 2018
9 Reads

Assessing function of electronic health records for real-world data generation.

BMJ Evid Based Med 2018 Nov 26. Epub 2018 Nov 26.

US Food and Drug Administration, Silver Spring, Maryland, USA.

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http://ebm.bmj.com/lookup/doi/10.1136/bmjebm-2018-111111
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http://dx.doi.org/10.1136/bmjebm-2018-111111DOI Listing
November 2018
23 Reads

Evidence-based practice education for healthcare professions: an expert view.

BMJ Evid Based Med 2018 Nov 15. Epub 2018 Nov 15.

Catherine McAuley School of Nursing and Midwifery, University College Cork, Cork, Ireland.

Internationally, evidence-based practice (EBP) is recognised as a foundational element of healthcare professional education. Achieving competency in this area is a complex undertaking that is reflected in disparities between 'best EBP' and actual clinical care. The effective development and implementation of professional education to facilitate EBP remains a major and immediate challenge. Read More

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http://ebm.bmj.com/lookup/doi/10.1136/bmjebm-2018-111019
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http://dx.doi.org/10.1136/bmjebm-2018-111019DOI Listing
November 2018
19 Reads

Preoperative physiotherapy education prevented postoperative pulmonary complications following open upper abdominal surgery.

Authors:
Shane Patman

BMJ Evid Based Med 2019 04 15;24(2):74-75. Epub 2018 Nov 15.

School of Physiotherapy, University of Notre Dame Australia, Fremantle, Western Australia, Australia.

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http://dx.doi.org/10.1136/bmjebm-2018-110985DOI Listing

Individuals with high-risk adenomas are at elevated risk for colorectal cancer.

BMJ Evid Based Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Veterans Affairs Medical Center, VA Medical Center, White River Junction, Vermont, USA.

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http://dx.doi.org/10.1136/bmjebm-2018-111087DOI Listing
November 2018