225,102 results match your criteria BMJ USA[Journal]


Patterns of high-risk prescribing and other factors in relation to receipt of a home medicines review: a prospective cohort investigation among adults aged 45 years and over in Australia.

BMJ Open 2019 Feb 15;9(2):e027305. Epub 2019 Feb 15.

Research School of Population Health, Australian National University, Canberra, Sydney, Australia.

Objectives: To quantify the relationship between home medicines review (HMR) receipt in older adults and sociodemographic, medication-related and health factors.

Design: Prospective cohort analysis.

Settings, Participants, Measurements: Questionnaire data from a population-based cohort study of individuals aged ≥45 years, Sydney, Australia were linked with primary healthcare data, medication and hospitalisation data, to ascertain factors associated with HMR receipt during the period July 2009-June 2014. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027305DOI Listing
February 2019

Novel use of tranexamic acid to reduce the need for Nasal Packing in Epistaxis (NoPac) randomised controlled trial: research protocol.

BMJ Open 2019 Feb 15;9(2):e026882. Epub 2019 Feb 15.

Research Design Service South West, Bristol, UK.

Introduction: Patients presenting to emergency departments (EDs) with epistaxis uncontrolled by subsequent simple first aid measures or application of topical vasoconstrictors will typically undergo anterior nasal packing. Packing is effective, but can be extremely painful and unpleasant and patients usually need hospital admission. Tranexamic acid (TXA) is a cheap, safe, readily available antifibrinolytic agent known to be beneficial in a variety of clinical settings where uncontrolled bleeding may be a problem. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026882DOI Listing
February 2019

Defining compassion in the digital health age: protocol for a scoping review.

BMJ Open 2019 Feb 15;9(2):e026338. Epub 2019 Feb 15.

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Introduction: The notion of compassion and compassionate care is playing an increasingly important role in health professional education and in the delivery of high-quality healthcare. Digital contexts, however, are not considered in the conceptualisation of compassionate care, nor is there guidance on how compassionate care is to be exercised while using digital health technologies. The widespread diffusion of digital health technologies provides new contexts for compassionate care, with both opportunities for new forms and instantiations of compassion as well as new challenges. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026338DOI Listing
February 2019

VaccHemInf project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients.

BMJ Open 2019 Feb 15;9(2):e026093. Epub 2019 Feb 15.

Département des Maladies Infectieuses et Tropicales, Hospices Civils de Lyon, Lyon, France.

Introduction: Immune reconstitution after haematopoietic stem cell transplantation (HSCT) is a complex and dynamic process, varying from a state of nearly complete immunosuppression to an expected full immune recovery. Specific vaccination guidelines recommend reimmunisation after HSCT but data regarding vaccine efficacy in this unique population are scarce. New immune functional assays could enable prediction of vaccine response in the setting of HSCT. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026093DOI Listing
February 2019

Paramedics' experiences of administering fascia iliaca compartment block to patients in South Wales with suspected hip fracture at the scene of injury: results of focus groups.

BMJ Open 2019 Feb 15;9(2):e026073. Epub 2019 Feb 15.

Medical School, Swansea University, Swansea, UK.

Objectives: To explore paramedics' experience of delivering fascia iliaca compartment block FICB) to patients with suspected hip fracture at the scene of injury.

Design: Focus groups within a randomised controlled trial.

Setting: Paramedics based at ambulance stations in the catchment area of one Emergency Department in South Wales, recruited and trained in a feasibility study about an alternative to routine prehospital pain management for patients with suspected hip fracture. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026073DOI Listing
February 2019

Lung Cancer App (LuCApp) study protocol: a randomised controlled trial to evaluate a mobile supportive care app for patients with metastatic lung cancer.

BMJ Open 2019 Feb 15;9(2):e025483. Epub 2019 Feb 15.

Centre for Research in Health and Social Care Management (CERGAS), SDA Bocconi, Milano, Italy.

Introduction: Mobile health technologies may enhance patient empowerment and data integration along the whole care continuum. However, these interventions pose relatively new regulatory, organisational and technological challenges that limit appropriate evaluation. Lung Cancer App (LuCApp) is a mobile application developed by researchers and clinicians to promote real-time monitoring and management of patients' symptoms. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025483DOI Listing
February 2019

Trends in resource use and effectiveness of ultrasound detection of fetal structural anomalies in France: a multiple registry-based study.

BMJ Open 2019 Feb 15;9(2):e025482. Epub 2019 Feb 15.

Fetal Medicine Department, Sorbonne University, AP-HP, Armand Trousseau Hospital, Paris, France.

Objective: To analyse trends in the number of ultrasound examinations in relation to the effectiveness of prenatal detection of birth defects using population-based data in France.

Design: A multiple registry-based study of time trends in resource use (number of ultrasounds) and effectiveness (proportion of cases prenatally diagnosed).

Setting: Three registries of congenital anomalies and claims data on ultrasounds for all pregnant women in France. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025482DOI Listing
February 2019

Medical management of acute upper respiratory infections in an urban primary care out-of-hours facility: cross-sectional study of patient presentations and expectations.

BMJ Open 2019 Feb 15;9(2):e025396. Epub 2019 Feb 15.

Graduate Entry Medical School, University of Limerick Faculty of Education and Health Sciences, Limerick, Ireland.

Objectives: The purpose of this study was to examine the expectations of patients attending an urban primary care out-of-hours (OOH) facility with acute upper respiratory tract infection (acute URTI) regarding clinical examination, symptom management, information on their condition, reassurance, antibiotic treatment and other possible options including referral.

Design: Cross-sectional design.

Setting: One urban primary care OOH facility located in the midwest of Ireland. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025396DOI Listing
February 2019

Systematic review of clinical outcome reporting in randomised controlled trials of burn care.

BMJ Open 2019 Feb 15;9(2):e025135. Epub 2019 Feb 15.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Introduction: Systematic reviews collate trial data to provide evidence to support clinical decision-making. For effective synthesis, there must be consistency in outcome reporting. There is no agreed set of outcomes for reporting the effect of burn care interventions. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025135DOI Listing
February 2019

Breastfeeding and behavioural problems: Propensity score matching with a national cohort of infants in Chile.

BMJ Open 2019 Feb 15;9(2):e025058. Epub 2019 Feb 15.

Psychology School, Pontificia Universidad Católica de Chile, Santiago, Chile.

Importance: Potential effects of breast feeding on children's behaviour remains an elusive debate given inherent methodological challenges. Propensity score matching affords benefits by ensuring greater equivalence on observable social and health determinants, helping to reduce bias between groups.

Objectives: We examined whether the duration of breast feeding had an impact on children's externalising and internalising behaviours. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025058DOI Listing
February 2019

Comparison of the EQ-5D 3L and the SF-6D (SF-36) contemporaneous utility scores in patients with chronic kidney disease in Sri Lanka: a cross-sectional survey.

BMJ Open 2019 Feb 15;9(2):e024854. Epub 2019 Feb 15.

Australian Centre for Health Services Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

Objectives: The aim of this study was to compare utility weights of EuroQoL-five-dimension-3 levels (EQ-5D-3L) and Short-Form six-dimension (SF-6D) in a representative cohort of patients with chronic kidney disease (CKD). A cost-utility analysis (CUA) is designed to report the change to costs required to achieve an estimated change to quality-adjusted life years (QALYs). The quality component of a QALY is measured by utility. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024854DOI Listing
February 2019

Frailty in the context of rehabilitation interventions for adults: protocol for a scoping review.

BMJ Open 2019 Feb 15;9(2):e024838. Epub 2019 Feb 15.

Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.

Introduction: Although a growing number of frail adults can benefit from rehabilitation services, few are included in rehabilitation services, and reasons for their exclusion are not well understood. To inform research directions in rehabilitation for all adults (aged 18 years and older), we will conduct a scoping review to describe (1) the characteristics of frail adult individuals included in rehabilitation interventions (eg, age range, inclusion and exclusion criteria that are applied), (2) the type of rehabilitation interventions that are used for individuals who are considered frail and (3) the commonly reported outcome measures used for these rehabilitation interventions.

Methods: This scoping review will be guided by Arksey and O'Malley's methodological framework. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024838DOI Listing
February 2019

Burden of non-accidental mortality attributable to ambient temperatures: a time series study in a high plateau area of southwest China.

BMJ Open 2019 Feb 15;9(2):e024708. Epub 2019 Feb 15.

Department of Preventive Medicine, Shantou University Medical College, Shantou, China.

Objective: To examine the total non-accidental mortality burden attributable to ambient temperatures and assess the effect modification of the burden by specific causes of death and individual characteristics in a high plateau area in southwest China.

Methods: Using daily mortality and meteorological data from 2009 to 2016, we applied a quasi-Poisson model combined with a distributed lag non-linear model to estimate the temperature-mortality association with the assessment of attributable fraction and number. We calculated attributable fractions and deaths with 95% empirical CIs (eCIs), that were due to cold and heat, defined as temperatures below and above the median temperature, and for mild and extreme temperatures, defined by cut-offs at the 2. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024708DOI Listing
February 2019

Therapist-guided and parent-guided internet-delivered behaviour therapy for paediatric Tourette's disorder: a pilot randomised controlled trial with long-term follow-up.

BMJ Open 2019 Feb 15;9(2):e024685. Epub 2019 Feb 15.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Objective: Behaviour therapy (BT) for Tourette's disorder (TD) and persistent (chronic) motor or vocal tic disorder (PTD) is rarely available. We evaluated the feasibility of adapting two existing BT protocols for TD/PTD (habit reversal training (HRT) and exposure and response prevention (ERP)) into a therapist-guided and parent-guided online self-help format.

Design: A pilot, single-blind, parallel group randomised controlled trial. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024685DOI Listing
February 2019

Quality of reporting of outcomes in trials of therapeutic interventions for pressure ulcers in adults: a protocol for a systematic survey.

BMJ Open 2019 Feb 15;9(2):e024633. Epub 2019 Feb 15.

Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.

Pressure ulcers (PUs) have a high incidence, especially in hospital units. Randomised clinical trials (RCTs) of therapeutic interventions for PU should include a clear description of the outcomes and results to enhance transparency and replicability.

Objectives: The primary objective of this study is to assess the completeness of the descriptions of the outcomes of therapeutic interventions in RCTs in adult patients with PU. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024633DOI Listing
February 2019

Impact of repeated hospital accreditation surveys on quality and reliability, an 8-year interrupted time series analysis.

BMJ Open 2019 Feb 15;9(2):e024514. Epub 2019 Feb 15.

Statistical Society-Central Luzon State University, Luzon, The Philippines.

Objective: To evaluate whether hospital re-accreditation improves quality, patient safety and reliability over three accreditation cycles by testing the accreditation life cycle model on quality measures.

Design: The validity of the life cycle model was tested by calibrating interrupted time series (ITS) regression equations for 27 quality measures. The change in the variation of quality over the three accreditation cycles was evaluated using the Levene's test. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024514DOI Listing
February 2019

Performance of biological mesh materials in abdominal wall reconstruction: study protocol for a randomised controlled trial.

BMJ Open 2019 Feb 15;9(2):e024091. Epub 2019 Feb 15.

Department of Surgery, University of Calgary and the Foothills Medical Centre, Calgary, Alberta, Canada.

Introduction: Abdominal wall hernias are a common source of morbidity and mortality. The use of biological mesh has become an important adjunct in successful abdominal wall reconstruction. There are a variety of biological mesh products available; however, there is limited evidence supporting the use of one type over another. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024091DOI Listing
February 2019

Using specialist screening practitioners (SSPs) to increase uptake of bowel scope (flexible sigmoidoscopy) screening: results of a feasibility single-stage phase II randomised trial.

BMJ Open 2019 Feb 15;9(2):e023801. Epub 2019 Feb 15.

Research Department of Behavioural Science and Health, University College London, London, UK.

Objective: To determine the feasibility of specialist screening practitioners (SSPs) offering patient navigation (PN) to facilitate uptake of bowel scope screening (BSS) among patients who do not confirm or attend their appointment.

Design: A single-stage phase II trial.

Setting: South Tyneside District Hospital, Tyne and Wear, England, UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023801DOI Listing
February 2019

Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial.

BMJ Open 2019 Feb 15;9(2):e023765. Epub 2019 Feb 15.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.

Introduction: Acute severe ulcerative colitis (ASUC) is a severe manifestation of ulcerative colitis (UC) that warrants hospitalisation. Despite significant advances in therapeutic options for UC and in the medical management of steroid-refractory ASUC, the initial treatment paradigm has not changed since 1955 and is based on the use of intravenous corticosteroids. This treatment is successful in approximately 50% of patients but failure of this and subsequent medical therapy still occurs, with colectomy rates of up to 40% reported. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023765DOI Listing
February 2019

PROFIT, a PROspective, randomised placebo controlled feasibility trial of Faecal mIcrobiota Transplantation in cirrhosis: study protocol for a single-blinded trial.

BMJ Open 2019 Feb 15;9(2):e023518. Epub 2019 Feb 15.

James Black Centre, School of Immunology & Microbial Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.

Introduction: Patients with advanced cirrhosis have enteric bacterial dysbiosis and translocation of bacteria and their products across the gut epithelial barrier. This culminates in systemic inflammation and endotoxaemia, inducing innate immune dysfunction which predisposes to infection, and development of complications such as bleeding, sepsis and hepatic encephalopathy. This feasibility study aims to assess the safety of administering faecal microbiota transplantion to patients with cirrhosis and explore the effect of the intervention on their prognosis by achieving restoration of a healthy gut microbiome. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023518DOI Listing
February 2019

Can a tool developed for industry be used to assess fatigue risk in medical rotas? A pilot study of foundation doctors' rotas in a tertiary centre.

BMJ Open 2019 Feb 15;9(2):e023470. Epub 2019 Feb 15.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Objectives: To determine the feasibility and ease of using a pre-existing health and safety executive fatigue risk calculator to assess doctors' rotas.

Design: Observational.

Setting: A large tertiary-referral teaching hospital in the UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023470DOI Listing
February 2019

Industrially produced fat in popular foods in 15 countries of the former Soviet Union from 2015 to 2016: a market basket investigation.

Authors:
Steen Stender

BMJ Open 2019 Feb 15;9(2):e023184. Epub 2019 Feb 15.

Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.

Objective: To minimise the intake of industrially produced fat (I-TF) and decrease the risk of coronary heart disease, several countries have implemented a legislative restriction on I-TF in foods. The objective of this study was to investigate the presence of I-TF in biscuits/cakes/wafers in 15 countries of the former Soviet Union that all have a high coronary mortality rate compared with countries in Western Europe.

Methods: Three large supermarkets in 15 capitals were visited in 2015 or 2016. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023184DOI Listing
February 2019

Does sector matter for the quality of care services? A secondary analysis of social care services regulated by the Care Inspectorate in Scotland.

BMJ Open 2019 Feb 15;9(2):e022975. Epub 2019 Feb 15.

Department of Social Policy, Sociology and Criminology, University of Birmingham, Birmingham, UK.

Objectives: Social services are increasingly commissioned to third and for-profit sector providers, but little is known about whether and how these changes influence quality indicators. We assessed quality-related outcomes across for-profit, public and third sector organisations delivering social care services.

Design: A secondary analysis was conducted on publically available data collected by the independent regulator of social care organisations in Scotland. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022975DOI Listing
February 2019

Cohort profile: the Danish Future Occupation of Children and Adolescents cohort (the FOCA cohort): education, work-life, health and living conditions in a life-course perspective.

BMJ Open 2019 Feb 15;9(2):e022784. Epub 2019 Feb 15.

Department of Public Health, University of Aarhus, Aarhus, Denmark.

Purpose: The Future Occupation of Children and Adolescents cohort (the FOCA cohort) is a large population-based cohort study that was established as a resource for research in order to study adolescence factors and future educational and vocational trajectories in a life-course perspective. The cohort covers a broad array of themes within public health, including diseases and health behaviours. Through linkage to register data on the participants' parents, the cohort allows investigation of parental effects over time on adolescents' behaviours and interactions across generations. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022784DOI Listing
February 2019

Can differences in length of stay between Dutch university hospitals and other hospitals be explained by patient characteristics? A cross-sectional study.

BMJ Open 2019 Feb 15;9(2):e021851. Epub 2019 Feb 15.

Radboud Institute for Health Sciences, IQ Healthcare, Radboud University Medical Center, Nijmegen, The Netherlands.

Objectives: The indicator unexpectedly long length of stay (UL-LOS) is used to gain insight into quality and safety of care in hospitals. The calculation of UL-LOS takes patients' age, main diagnosis and main procedure into account. University hospitals have relatively more patients with a UL-LOS than other hospitals. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-021851DOI Listing
February 2019

Conversion of other opioids to methadone: a retrospective comparison of two methods.

BMJ Support Palliat Care 2019 Feb 16. Epub 2019 Feb 16.

Department of Supportive and Palliative Care, Mater Health Services, Brisbane, Queensland, Australia

Context: A rapid method of methadone conversion known as the Perth Protocol is commonly used in Australian palliative care units. There has been no follow-up or validation of this method and no comparison between different methods of conversion.

Objectives: The primary objective of this study was to test the hypothesis that the achieved doses of methadone are independent of the conversion method (rapid vs slower). Read More

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http://dx.doi.org/10.1136/bmjspcare-2018-001645DOI Listing
February 2019

Liver transplant, toxoplasmosis and kidney stones: connecting the dots.

BMJ Case Rep 2019 Feb 15;12(2). Epub 2019 Feb 15.

Department of Nephrology, University of Florida College of Medicine, Gainesville, Florida, USA.

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http://dx.doi.org/10.1136/bcr-2019-229197DOI Listing
February 2019

Methemoglobinaemia with chronic phenazopyridine ingestion.

BMJ Case Rep 2019 Feb 15;12(2). Epub 2019 Feb 15.

Emergency Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1136/bcr-2018-227538DOI Listing
February 2019

rearranged acute lymphoblastic leukaemia presenting as a maxillary sinus mass with a discordant immunophenotypic profile from the bone marrow.

BMJ Case Rep 2019 Feb 15;12(2). Epub 2019 Feb 15.

Department of Pediatric Hematology-Oncology, University of California San Diego, San Diego, California, USA.

We describe an unusual case of pre-B lymphoblastic leukaemia presenting with a unilateral maxillary sinus mass in which biopsies of the primary mass and the bone marrow demonstrated conflicting immunophenotyping results. The extramedullary mass was consistent with a precursor B-cell malignancy, while the bone marrow was initially reported as a possible mature B-cell malignancy. The treatments for the two are fundamentally different, which necessitated a delay in the initiation of his chemotherapy until a clear diagnosis was made. Read More

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http://dx.doi.org/10.1136/bcr-2018-227400DOI Listing
February 2019

Spinal epidural lipomatosis following bilateral spinal decompression surgery.

BMJ Case Rep 2019 Feb 15;12(2). Epub 2019 Feb 15.

North Bristol NHS Trust, Bristol, UK.

A 73-year-old man underwent bilateral spinal decompression of L4/5 for severe spinal canal stenosis, requiring minimal analgesia and providing immediate relief. Two days post-operatively, he presented with new onset bilateral leg pain and difficulty mobilising. MRI demonstrated spinal epidural lipomatosis (SEL), which was not present pre-operatively, at L5/S1. Read More

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http://dx.doi.org/10.1136/bcr-2018-226985DOI Listing
February 2019

Neuroblastoma with an unusual ovarian metastasis in a 5-year-old girl.

BMJ Case Rep 2019 Feb 15;12(2). Epub 2019 Feb 15.

Department of Paediatric Surgery, Noah's Ark Children's Hospital, University Hospital of Wales, Cardiff, UK.

Neuroblastoma metastasizing to the ovary is rare. We report the 10th case and review the scarce literature. A 5-year-old girl with stage M neuroblastoma presented with an upper abdominal and a pelvic mass. Read More

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http://dx.doi.org/10.1136/bcr-2018-226038DOI Listing
February 2019

Use of a maternal newborn audit and feedback system in Ontario: a collective case study.

BMJ Qual Saf 2019 Feb 16. Epub 2019 Feb 16.

Better Outcomes Registry & Network (BORN), Children's Hospital of Eastern Ontario - Ottawa Children's Treatment Centre (CHEO-OCTC), Ottawa, Ontario, Canada.

Background: As part of a larger study examining the effectiveness of the Maternal Newborn Dashboard, an electronic audit and feedback system to improve maternal-newborn care practices and outcomes, the purpose of this study was to increase our understanding of factors explaining variability in performance after implementation of the Dashboard in Ontario, Canada.

Methods: A collective case study. A maximum variation sampling approach was used to invite hospitals reflecting different criteria to participate in a 1-day to 2-day site visit by the research team. Read More

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http://dx.doi.org/10.1136/bmjqs-2018-008354DOI Listing
February 2019

Johnson and Johnson will be first US pharma company to reveal a drug's price in TV advertisement.

Authors:
Owen Dyer

BMJ 2019 Feb 15;364:l751. Epub 2019 Feb 15.

Montreal, Canada.

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http://dx.doi.org/10.1136/bmj.l751DOI Listing
February 2019

Medical cannabis: no NHS patients have benefited from law change, say campaigners.

Authors:
Richard Hurley

BMJ 2019 Feb 15;364:l753. Epub 2019 Feb 15.

BMJ.

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http://dx.doi.org/10.1136/bmj.l753DOI Listing
February 2019

NICE responds to article on patient organisations declaring financial interests.

Authors:
Gillian Leng

BMJ 2019 Feb 15;364:l733. Epub 2019 Feb 15.

National Institute for Health and Care Excellence, London SW1A 2BU, UK.

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http://dx.doi.org/10.1136/bmj.l733DOI Listing
February 2019

GP at Hand is given go ahead to expand to Birmingham.

Authors:
Gareth Iacobucci

BMJ 2019 Feb 15;364:l748. Epub 2019 Feb 15.

The BMJ.

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http://dx.doi.org/10.1136/bmj.l748DOI Listing
February 2019

Using data for improvement.

Authors:
Amar Shah

BMJ 2019 Feb 15;364:l189. Epub 2019 Feb 15.

East London NHS Foundation Trust, London, E1 8DE, UK.

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http://dx.doi.org/10.1136/bmj.l189DOI Listing
February 2019

Sixty seconds on . . . waiting times.

Authors:
Nigel Hawkes

BMJ 2019 Feb 15;364:l752. Epub 2019 Feb 15.

London, UK.

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http://dx.doi.org/10.1136/bmj.l752DOI Listing
February 2019

Primary care networks: five minutes with . . . Sohail Munshi.

Authors:
Gareth Iacobucci

BMJ 2019 Feb 15;364:l754. Epub 2019 Feb 15.

The BMJ.

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http://dx.doi.org/10.1136/bmj.l754DOI Listing
February 2019

Lifestyle changes may be more important than drugs for mild hypertension.

BMJ 2019 Feb 15;364:l571. Epub 2019 Feb 15.

Bazian, Economist Intelligence Unit healthcare, London, UK.

The studySheppard JP, Stevens S, Stevens R, Martin U, Mant J, Hobbs R, McManus R. Benefits and harms of antihypertensive treatment in low-risk patients with mild hypertension.Published on 1 December 2018 2018;178:1626-34. Read More

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http://dx.doi.org/10.1136/bmj.l571DOI Listing
February 2019

Health minister says women harmed by mesh should sue their surgeons.

Authors:
Jacqui Wise

BMJ 2019 Feb 14;364:l738. Epub 2019 Feb 14.

London.

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http://dx.doi.org/10.1136/bmj.l738DOI Listing
February 2019

The prominence of e-cigarettes is a symptom of decades of failure to tackle smoking properly.

BMJ 2019 Feb 14;364:l647. Epub 2019 Feb 14.

National Heart and Lung Institute, Imperial College London, UK

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http://dx.doi.org/10.1136/bmj.l647DOI Listing
February 2019

Ending the doctor-nurse game by enhancing the role of the ward nurse.

Authors:
James S Brown

BMJ 2019 Feb 14;364:l698. Epub 2019 Feb 14.

Liverpool University, Aintree University Hospital, Liverpool L9 7AL, UK.

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http://dx.doi.org/10.1136/bmj.l698DOI Listing
February 2019

Concealed diagnosis of duodenal perforation in a patient with emphysematous pyelonephritis: the dilemma of air in the right perirenal space.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.1136/bcr-2018-228629DOI Listing
February 2019

Dopamine agonist-responsive Cushing's disease.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of Endocrinology, University Hospital Zürich, Zürich, Switzerland.

A 47-year-old Caucasian man was referred to our clinic with a severe clinical and biochemical phenotype of endogenous hypercortisolism for further evaluation and treatment. In addition to confirming adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome, we found left temporal hemianopsia, massively increased prolactin, increased growth hormone/insulin-like growth factor 1 values, hypogonadotropic hypogonadism and central hypothyroidism. As the cause of these abnormalities we revealed an invasive macroadenoma of the pituitary secreting ACTH, prolactin and growth hormone, resulting not only in a clinically predominant picture of Cushing's syndrome but also causing hypogonadotropic hypogonadism and central hypothyroidism. Read More

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http://dx.doi.org/10.1136/bcr-2018-228045DOI Listing
February 2019
3 Reads

Bilateral osteonecrosis of the hip in panhypopituitarism.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Osteonecrosis, also known as avascular necrosis, is a condition that causes significant morbidity and loss of function. It is a common complication seen with supraphysiological steroid use. Early diagnosis is critical as it impacts prognosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-227471DOI Listing
February 2019
2 Reads

Fitz-Hugh-Curtis syndrome.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of General Medicine, Chiba University Hospital, Chiba, Japan.

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http://dx.doi.org/10.1136/bcr-2019-229326DOI Listing
February 2019
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Diffuse plane xanthoma developing in association with prior monoclonal gammopathy.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of Dermatology, Stadtisches Klinikum Muenchen GmbH, Muenchen, Germany.

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http://dx.doi.org/10.1136/bcr-2018-229164DOI Listing
February 2019

Biceps tendon rupture associated with ciprofloxacin use for spontaneous bacterial peritonitis prophylaxis.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Internal Medicine, Sparrow Hospital, Lansing, Michigan, USA.

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http://dx.doi.org/10.1136/bcr-2018-229116DOI Listing
February 2019

Atypical anaplastic astrocytoma with unique molecular features and diffuse leptomeningeal spread in a child with long-term survival.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA.

Paediatric high-grade gliomas, including glioblastoma and anaplastic astrocytoma, make up 8%-12% of paediatric central nervous system tumours and have poor prognosis, with 2-year survival less than 30% and overall survival less than 10%. The only known prognostic factors in this population include extent of resection and tumour histological grade. We present the case of a 9-year-old boy with disseminated anaplastic astrocytoma treated with subtotal resection, craniospinal radiation and temozolomide, with 8-year survival despite metastatic disease at presentation and subtotal resection. Read More

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http://dx.doi.org/10.1136/bcr-2018-228153DOI Listing
February 2019