12,341 results match your criteria BMJ Quality & Safety [Journal]


Helminth infections, atopy, asthma and allergic diseases: protocol for a systematic review of observational studies worldwide.

BMJ Open 2020 May 25;10(5):e038085. Epub 2020 May 25.

Department of Allergy & Clinical Immunology, Cova da Beira University Hospital Centre, Covilhã, Portugal

Introduction: Childhood infections, particularly those caused by helminths are considered to be important environmental exposures influencing the development of allergic diseases. However, epidemiological studies focusing on the relationship between helminth infections and risk of allergic diseases, performed worldwide, show inconsistent findings. Previous systematic reviews of observational studies published 10 or more years ago showed conflicting findings for effects of helminths on allergic diseases. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-038085DOI Listing

Drugs associated with quality-related events reported by community pharmacies in Nova Scotia, Canada.

BMJ Open Qual 2020 May;9(2)

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/bmjoq-2019-000853DOI Listing

Scope, quality, and inclusivity of clinical guidelines produced early in the covid-19 pandemic: rapid review.

BMJ 2020 May 26;369:m1936. Epub 2020 May 26.

Epidemic Research Group, University of Oxford, Oxford OX3 7LG, UK.

Objective: To appraise the availability, quality, and inclusivity of clinical guidelines produced in the early stage of the coronavirus disease 2019 (covid-19) pandemic.

Design: Rapid review.

Data Sources: Ovid Medline, Ovid Embase, Ovid Global Health, Scopus, Web of Science Core Collection, and WHO Global Index Medicus, searched from inception to 14 Mar 2020. Read More

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http://dx.doi.org/10.1136/bmj.m1936DOI Listing

Work effort, readability and quality of pharmacy transcription of patient directions from electronic prescriptions: a retrospective observational cohort analysis.

BMJ Qual Saf 2020 May 25. Epub 2020 May 25.

Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA

Background: Free-text directions generated by prescribers in electronic prescriptions can be difficult for patients to understand due to their variability, complexity and ambiguity. Pharmacy staff are responsible for transcribing these directions so that patients can take their medication as prescribed. However, little is known about the quality of these transcribed directions received by patients. Read More

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http://dx.doi.org/10.1136/bmjqs-2019-010405DOI Listing

Changes in the quality of kefir fortified with anthocyanin-rich juices during storage.

Food Chem 2020 May 5;326:126977. Epub 2020 May 5.

Department of Food Engineering, Faculty of Engineering, Ankara University, Gölbaşı, 06830 Ankara, Turkey.

Changes in sensorial, chemical and microbiological qualities of kefirs fortified with black carrot (KBCJ), black mulberry (KBMJ), pomegranate (KPJ), and strawberry (KSJ) juices at different concentrations (10, 25 and 50%, w/w) were monitored throughout storage at 4 °C for 12 weeks. The most preferred kefirs by the sensorial panel were KSJ and KPJ, followed by KBMJ and KBCJ. KBMJ was associated with the highest anthocyanin stability, followed by KPJ, KSJ, and KBCJ. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.126977DOI Listing

Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis.

BMJ Open 2020 May 21;10(5):e036981. Epub 2020 May 21.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Introduction: Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to adverse pregnancy outcomes. Metformin is often used for the prevention and management of GDM; however, its use in pregnancy continues to be debated. The Metformin in Pregnancy Study aims to use individual patient data (IPD) meta-analysis to clarify the efficacy and safety of metformin use in pregnancy and to identify relevant knowledge gaps. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-036981DOI Listing

Protocol for a randomised controlled trial of Subacromial spacer for Tears Affecting Rotator cuff Tendons: a Randomised, Efficient, Adaptive Clinical Trial in Surgery (START:REACTS).

BMJ Open 2020 May 21;10(5):e036829. Epub 2020 May 21.

University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

Introduction: Shoulder pain due to irreparable rotator cuff tears can cause substantial disability, but treatment options are limited. A balloon spacer is a relatively simple addition to a standard arthroscopic debridement procedure, but it is costly and there is no current randomised trial evidence to support its use. This trial will evaluate the clinical and cost-effectiveness of a subacromial balloon spacer for individuals undergoing arthroscopic debridement for irreparable rotator cuff tears. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-036829DOI Listing

Nurses' knowledge of peripherally inserted central catheter maintenance and its influencing factors in Hunan province, China: a cross-sectional survey.

BMJ Open 2020 May 21;10(5):e033804. Epub 2020 May 21.

Xiangya Nursing School, Central South University, Changsha, Hunan, China.

Objectives: The present study aimed to assess the level of knowledge on peripherally inserted central catheter (PICC) maintenance among nurses in China and to analyse the related factors influencing this variable.

Design: A cross-sectional survey.

Setting: Ninety-one hospitals at three different levels in Hunan Province, China: county hospitals, municipal hospitals and provincial hospitals. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033804DOI Listing

Association between organ damage and mortality in systemic lupus erythematosus: a systematic review and meta-analysis.

BMJ Open 2020 May 21;10(5):e031850. Epub 2020 May 21.

BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, Maryland, USA

Objective: At least half of patients with systemic lupus erythematosus (SLE) develop organ damage as a consequence of autoimmune disease or long-term therapeutic steroid use. This study synthesised evidence on the association between organ damage and mortality in patients with SLE.

Design: Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-031850DOI Listing

The cost-effectiveness of using results-based financing to reduce maternal and perinatal mortality in Malawi.

BMJ Glob Health 2020 May;5(5)

Department of Global Public Health and Primary Care, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.

Introduction: Results-based financing (RBF) is being promoted to increase coverage and quality of maternal and perinatal healthcare in sub-Saharan Africa (SSA) countries. Evidence on the cost-effectiveness of RBF is limited. We assessed the cost-effectiveness within the context of an RBF intervention, including performance-based financing and conditional cash transfers, in rural Malawi. Read More

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http://dx.doi.org/10.1136/bmjgh-2019-002260DOI Listing

Covid-19 care before, during, and beyond the hospital.

BMJ 2020 05 22;369:m2035. Epub 2020 May 22.

Division of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, 750 North Lake Shore Drive, 10th Floor, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1136/bmj.m2035DOI Listing

A systematic review of guidelines for lymphedema and the need for contemporary intersocietal guidelines for the management of lymphedema.

J Vasc Surg Venous Lymphat Disord 2020 May 20. Epub 2020 May 20.

Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Mass.

Objective: Lymphedema (LED) affects an estimated 35 million patients in the United States and a staggering 140,200 million people worldwide, yet LED is the forgotten vascular disease. Whereas the diagnosis and treatment of arterial and venous diseases have been strengthened by the development of clinical practice guidelines (CPGs), few CPGs are available for LED. Moreover, for CPGs to have their greatest impact, they should be both of high quality and developed using the most rigorous evidence-based methods. Read More

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http://dx.doi.org/10.1016/j.jvsv.2020.03.006DOI Listing

Rapid implementation of virtual clinics due to COVID-19: report and early evaluation of a quality improvement initiative.

BMJ Open Qual 2020 05;9(2)

Improvement Team, Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK.

Background: The COVID-19 outbreak has placed the National Health Service under significant strain. Social distancing measures were introduced in the UK in March 2020 and virtual consultations (via telephone or video call) were identified as a potential alternative to face-to-face consultations at this time.

Local Problem: The Royal National Orthopaedic Hospital (RNOH) sees on average 11 200 face-to-face consultations a month. Read More

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http://dx.doi.org/10.1136/bmjoq-2020-000985DOI Listing

Understanding quality systems in the South African prehospital emergency medical services: a multiple exploratory case study.

BMJ Open Qual 2020 May;9(2)

Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.

Introduction: In South Africa (SA), prehospital emergency care is delivered by emergency medical services (EMS) across the country. Within these services, quality systems are in their infancy, and issues regarding transparency, reliability and contextual relevance have been cited as common concerns, exacerbated by poor communication, and ineffective leadership. As a result, we undertook a study to assess the current state of quality systems in EMS in SA, so as to determine priorities for initial focus regarding their development. Read More

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http://dx.doi.org/10.1136/bmjoq-2020-000946DOI Listing

Problem with patient decision aids.

BMJ Evid Based Med 2020 May 21. Epub 2020 May 21.

Institute for Musculoskeletal Health, Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

Patient decision aids are evidence-based tools designed to help patients make specific and deliberated choices among healthcare options. Research shows that patient decision aids increase knowledge, accuracy of risk perceptions, alignment of care with patient values and preferences, and patient involvement in decision making. Some patient decision aids can reduce the use of invasive and potentially low-value procedures. Read More

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http://dx.doi.org/10.1136/bmjebm-2020-111371DOI Listing

Compliance with national guidelines for antibiotic prophylaxis in hip fracture patients: a quality assessment study of 13 329 patients in the Norwegian Hip Fracture Register.

BMJ Open 2020 May 20;10(5):e035598. Epub 2020 May 20.

Orthopaedic Department, Baerum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.

Objective: We assessed compliance with new guidelines for prophylactic antibiotics in hip fracture surgery in Norway introduced in 2013.

Design: The data from the Norwegian Hip Fracture Register was used to assess the proportion of antibiotics given according to the national guidelines.

Setting: All hospitals in Norway performing hip fracture surgery in the period from 2011 to 2016. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035598DOI Listing

Understanding the patient experience of early unplanned hospital readmission following acute care discharge: a qualitative descriptive study.

BMJ Open 2020 May 20;10(5):e034728. Epub 2020 May 20.

School of Nursing and Midwifery, Centre for Quality and Patient Safety Research, Institute for Health Transformation, Deakin University, Geelong, Victoria, Australia.

Objectives: To understand from a patient and carer perspective: (1) what features of the discharge process could be improved to avoid early unplanned hospital readmission (within 72 hours of acute care discharge) and (2) what elements of discharge planning could have enhanced the discharge experience.

Design: A qualitative descriptive design was used. Study data were collected using semi-structured interviews that were transcribed verbatim and analysed using inductive thematic analysis. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034728DOI Listing

Medication-related interventions delivered both in hospital and following discharge: a systematic review and meta-analysis.

BMJ Qual Saf 2020 May 20. Epub 2020 May 20.

Department of Clinical Pharmacy, OLVG, Amsterdam, North-Holland, The Netherlands

Background: Harm due to medications is common during the transition from hospital to home. Approaches that seek to prevent harm often involve isolated medication-related interventions and show conflicting results. However, until now, no review has focused on the effect of intervention components delivered both in hospital and following discharge from hospital to home. Read More

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http://dx.doi.org/10.1136/bmjqs-2020-010927DOI Listing

Quality of informed consent documents among US. hospitals: a cross-sectional study.

BMJ Open 2020 May 19;10(5):e033299. Epub 2020 May 19.

Center for Outcomes Research and Evaluation, Yale New Haven Health System, New Haven, Connecticut, USA.

Objective: To determine whether informed consent for surgical procedures performed in US hospitals meet a minimum standard of quality, we developed and tested a quality measure of informed consent documents.

Design: Retrospective observational study of informed consent documents.

Setting: 25 US hospitals, diverse in size and geographical region. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033299DOI Listing

An instrument for assessing the quality of informed consent documents for elective procedures: development and testing.

BMJ Open 2020 May 19;10(5):e033297. Epub 2020 May 19.

Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut, USA.

Objective: To develop a nationally applicable tool for assessing the quality of informed consent documents for elective procedures.

Design: Mixed qualitative-quantitative approach.

Setting: Convened seven meetings with stakeholders to obtain input and feedback on the tool. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033297DOI Listing

Global and regional geographical prevalence of depression in gastric cancer: a systematic review and meta-analysis.

BMJ Support Palliat Care 2020 May 20. Epub 2020 May 20.

Department of Epidemiology, Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Sharoud, Iran

Background: Substantial uncertainty exists about the prevalence of depression in patients with gastric cancer. We aimed to summarise the global and regional pooled prevalence of depression among patients with gastric cancer.

Method: Up to February 2020, we searched PubMed/MEDLINE, Embase, Scopus, Web of science (ISI) and PsychINFO to identify published studies on the prevalence of depression among patients with gastric cancer. Read More

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http://dx.doi.org/10.1136/bmjspcare-2019-002050DOI Listing

Using Lean Six Sigma methodologies to reduce risk of warfarin medication omission at hospital discharge.

BMJ Open Qual 2020 May;9(2)

Operations Improvement, Memorial Health System, Springfield, Illinois, United States

Unintended omission of warfarin, an anticoagulant used to prevent and treat thromboembolic events, can lead to serious medical complications. These complications include increased medical costs, hospitalisations and significant patient harm, including increased risk of thrombosis and mortality. Chart review of discharged patients at our institution revealed an average of one patient/month with warfarin omitted from the discharge plan despite intention to continue therapy. Read More

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http://dx.doi.org/10.1136/bmjoq-2019-000715DOI Listing

Effect of an editorial intervention to improve the completeness of reporting of randomised trials: a randomised controlled trial.

BMJ Open 2020 May 18;10(5):e036799. Epub 2020 May 18.

Statistics and Operations Research Department, Universitat Politecnica de Catalunya, Barcelona, Spain.

Objective: To evaluate the impact of an editorial intervention to improve completeness of reporting of reports of randomised trials.

Design: Randomised controlled trial (RCT).

Setting: 's quality improvement programme. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-036799DOI Listing

Protocol of a randomised controlled trial assessing the impact of physical activity on bone health in children with inflammatory bowel disease.

BMJ Open 2020 May 18;10(5):e036400. Epub 2020 May 18.

Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France, Lille, France.

Introduction: Low bone mineral density (BMD) is a frequent issue in children and adolescents with inflammatory bowel disease (IBD). Several studies in healthy populations have reported a positive impact of physical activity (PA) on bone health. Recently, an observational study in paediatric patients with IBD showed a significant positive relationship between daily PA and BMD. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036400DOI Listing

Qualitative accounts from Syrian mental health professionals: shared realities in the context of conflict and forced displacement.

BMJ Open 2020 May 18;10(5):e034291. Epub 2020 May 18.

Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.

Objectives: To explore the impact of the provision of care of forcibly displaced Syrian mental health professionals (MHPs) to Syrian clients in the community given shared experiences and backgrounds with clients.

Design: A qualitative study using thematic analysis of in-depth semistructured interviews to explore shared realities, self-disclosure and the impact of providing therapy.

Setting: Syrian MHPs operating in Gaziantep and Istanbul, Turkey, were interviewed. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034291DOI Listing

Maximising comfort: how do patients describe the care that matters? A two-stage qualitative descriptive study to develop a quality improvement framework for comfort-related care in inpatient settings.

BMJ Open 2020 May 18;10(5):e033336. Epub 2020 May 18.

Faculty of Medical & Health Sciences, The University of Auckland, Auckland, New Zealand.

Objective: To develop a multidimensional framework representing patients' perspectives on comfort to guide practice and quality initiatives aimed at improving patients' experiences of care.

Design: Two-stage qualitative descriptive study design. Findings from a previously published synthesis of 62 studies (stage 1) informed data collection and analysis of 25 semistructured interviews (stage 2) exploring patients' perspectives of comfort in an acute care setting. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033336DOI Listing

Patient-centred and economic effectiveness of a decision aid for patients with age-related cataract in China: study protocol of a randomised controlled trial.

BMJ Open 2020 May 18;10(5):e032242. Epub 2020 May 18.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Introduction: The need for cataract surgery is on the rise due to our ageing population and high demands for greater visual functioning. Although the majority of patients want to participate in a shared decision-making process, no decision aid has been available to improve the quality of decision. The present study aims to determine whether a decision aid increases informed decision about cataract surgery. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-032242DOI Listing

Does women's mobile phone ownership matter for health? Evidence from 15 countries.

BMJ Glob Health 2020 May;5(5)

International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Mobile phones have the potential to increase access to health information, improve patient-provider communication, and influence the content and quality of health services received. Evidence on the gender gap in ownership of mobile phones is limited, and efforts to link phone ownership among women to care-seeking and practices for reproductive maternal newborn and child health (RMNCH) have yet to be made. This analysis aims to assess household and women's access to phones and its effects on RMNCH health outcomes in 15 countries for which Demographic and Health Surveys data on phone ownership are available. Read More

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http://dx.doi.org/10.1136/bmjgh-2020-002524DOI Listing

Improving the use of the 'COUGH' bundle in Surgical High Dependency Unit, Ninewells Hospital, Dundee.

BMJ Open Qual 2020 May;9(2)

Surgical High Dependency Unit, Ninewells Hospital, NHS Tayside, Dundee, UK.

Developing respiratory complications postoperatively is one of the major determinants of longer hospital stay, morbidity, mortality and increased healthcare costs. The incidence of postoperative respiratory complications varies from 1% to 23%. Given that postoperative respiratory complications are relatively common and costly, there have been various studies which look at ways to reduce the risk of these occurring. Read More

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http://dx.doi.org/10.1136/bmjoq-2019-000851DOI Listing

Study protocol for a multicentre longitudinal mixed methods study to explore the Outcomes of ChildrEn and fAmilies in the first year after paediatric Intensive Care: the OCEANIC study.

BMJ Open 2020 May 17;10(5):e038974. Epub 2020 May 17.

Children and Young People Health Research, School of Health Sciences, University of Nottingham, Nottingham, Nottinghamshire, UK.

Introduction: Annually in the UK, 20 000 children become very ill or injured and need specialist care within a paediatric intensive care unit (PICU). Most children survive. However, some children and their families may experience problems after they have left the PICU including physical, functional and/or emotional problems. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-038974DOI Listing

Foot health and quality of life in patients with rheumatoid arthritis: a cross-sectional study.

BMJ Open 2020 May 17;10(5):e036903. Epub 2020 May 17.

Department Nursing and Podiatry, Universidad de Málaga, Malaga, Spain.

Objective: The aim of this study is to identify foot health factors related to the quality of life in patients with rheumatoid arthritis (RA).

Setting: In this cross-sectional study, a total of 293 subjects were analysed, 229 of whom were in the RA group and 64 in the control group. In the RA group, 173 patients were female, and 50 in the control group. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-036903DOI Listing

Rates, causes, place and predictors of mortality in adults with intellectual disabilities with and without Down syndrome: cohort study with record linkage.

BMJ Open 2020 May 17;10(5):e036465. Epub 2020 May 17.

Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Objectives: To investigate mortality in adults with intellectual disabilities: rates, causes, place, demographic and clinical predictors.

Design: Cohort study with record linkage to death data.

Setting: General community. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036465DOI Listing

Effectiveness and acceptability of metformin in preventing the onset of type 2 diabetes after gestational diabetes in postnatal women: a protocol for a randomised, placebo-controlled, double-blind feasibility trialOptimising health outcomes with Metformin to prevent diAbetes After pregnancy (OMAhA).

BMJ Open 2020 May 17;10(5):e036198. Epub 2020 May 17.

Barts Research Centre for Women's Health (BARC), Institute of Population Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Introduction: Up to half of all women diagnosed with gestational diabetes mellitus develop type 2 diabetes within 5 years after delivery. Metformin is effective in preventing type 2 diabetes in high-risk non-pregnant individuals, but its effect when commenced in the postnatal period is not known. We plan to assess the feasibility of evaluating metformin versus placebo in minimising the risk of dysglycaemia including type 2 diabetes after delivery in postnatal women with a history of gestational diabetes through a randomised trial. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036198DOI Listing
May 2020
2.063 Impact Factor

The comparative effectiveness of physical exercise interventions in individuals with chronic non-specific neck pain: protocol for a network meta-analysis.

BMJ Open 2020 May 17;10(5):e034846. Epub 2020 May 17.

RECOVER Injury Research Centre, NHMRC Centre of Research Excellence in Recovery Following Road Traffic Injuries, The University of Queensland, Brisbane, Queensland, Australia.

Introduction: Neck pain is a global burdensome problem, with a large proportion of neck pain cases becoming chronic. Although physical exercise is a commonly prescribed treatment, the evidence on the effectiveness of isolated exercise interventions remains limited. Traditional pairwise randomised controlled trials (RCTs) and meta-analyses are limited in only comparing two interventions. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034846DOI Listing

Behavioural and pharmaceutical interventions for the prevention of skin cancers in solid organ transplant recipients: a systematic review of randomised controlled trials.

BMJ Open 2020 May 17;10(5):e029265. Epub 2020 May 17.

Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.

Objectives: Solid organ transplant recipients are at increased risk of skin cancer, affecting more than 50% of recipients. We aimed to determine the effectiveness of interventions for behavioural change for sun protection or skin cancer prevention in solid organ transplant recipients.

Design: Systematic review. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-029265DOI Listing

Consensus on the exercise and dosage variables of an exercise training programme for chronic non-specific neck pain: protocol for an international e-Delphi study.

BMJ Open 2020 May 15;10(5):e037656. Epub 2020 May 15.

Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK

Introduction: Clinical guidelines and systematic reviews recommend exercise in the management of chronic non-specific neck pain. Although exercise training programmes that consist of both motor control exercise and exercises for the superficial cervical muscles (segmental exercises) are effective, the exercise variables including dosage vary considerably across trials or are poorly reported. This study aims to gain expert consensus on these exercise variables so that they can be described clearly using intervention reporting checklists to inform clinical practice and future clinical trials. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-037656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232615PMC

Geographic variation in preventable hospitalisations across Canada: a cross-sectional study.

BMJ Open 2020 May 15;10(5):e037195. Epub 2020 May 15.

Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.

Objective: The objective of this study is to examine the magnitude and pattern of small-area geographic variation in rates of preventable hospitalisations for ambulatory care-sensitive conditions (ACSC) across Canada (excluding Québec).

Design And Setting: A cross-sectional study conducted in Canada (excluding Québec) using data from the 2006 Canadian Census Health and Environment Cohort (CanCHEC) linked prospectively to hospitalisation records from the Discharge Abstract Database (DAD) for the three fiscal years: 2006-2007, 2007-2008 and 2008-2009.

Primary Outcome Measure: Preventable hospitalisations (ACSC). Read More

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http://dx.doi.org/10.1136/bmjopen-2020-037195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232620PMC

Performance of the Safer Nursing Care Tool to measure nurse staffing requirements in acute hospitals: a multicentre observational study.

BMJ Open 2020 May 15;10(5):e035828. Epub 2020 May 15.

National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care Wessex, University of Southampton, Southampton, Hampshire, UK.

Objectives: The best way to determine nurse staffing requirements on hospital wards is unclear. This study explores the precision of estimates of nurse staffing requirements made using the Safer Nursing Care Tool (SNCT) patient classification system for different sample sizes and investigates whether recommended staff levels correspond with professional judgements of adequate staffing.

Design: Observational study linking datasets of staffing requirements (estimated using a tool) to professional judgements of adequate staffing. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232629PMC

Response process validity of three patient reported outcome measures for people requiring kidney care: a think-aloud study using the EQ-5D-5L, ICECAP-A and ICECAP-O.

BMJ Open 2020 May 15;10(5):e034569. Epub 2020 May 15.

Health Economics Bristol, Population Health Sciences, University of Bristol, Bristol, UK.

Objectives: To determine the response process validity, feasibility of completion, acceptability and preferences for three patient-reported outcome measures that could be used in economic evaluation-the EQ-5D-5L, ICECAP-A and ICECAP-O-in people requiring kidney care.

Design: Participants were asked to 'think-aloud' while completing the EQ-5D-5L, ICECAP-A and ICECAP-O, followed by a semistructured interview. Five raters identified errors or struggles in completing the measures from the think-aloud component of the transcripts. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232621PMC

Impact of point-of-care tests in community pharmacies: a systematic review and meta-analysis.

BMJ Open 2020 May 15;10(5):e034298. Epub 2020 May 15.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

Objectives: To summarise the literature regarding the use of point-of-care test (POCT) in pharmacies versus control/usual care.

Design And Setting: Systematic review and random-effects meta-analysis in community pharmacy.

Data Sources: MEDLINE, Cochrane Central Register of Controlled Trials, Embase, ClinicalTrial. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232628PMC

Neuroleptic malignant syndrome in patients with cancer: a systematic review.

BMJ Support Palliat Care 2020 May 15. Epub 2020 May 15.

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan

Background: Antipsychotics potentially cause a low incidence of the side effect called neuroleptic malignant syndrome (NMS), which has a high mortality rate. However, few studies on NMS among patients with cancer exist.

Aims: We aimed to examine the characteristics of antipsychotic-induced NMS among patients with cancer. Read More

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http://dx.doi.org/10.1136/bmjspcare-2020-002200DOI Listing

Growth hormone treatment in Prader-Willi syndrome patients: systematic review and meta-analysis.

BMJ Paediatr Open 2020 29;4(1):e000630. Epub 2020 Apr 29.

Universidade de Sao Paulo, Sao Paulo, Brazil.

Background: Growth hormone (GH) treatment is currently recommended in Prader-Willi syndrome (PWS) patients.

Objectives: To evaluate the impact (efficacy and safety) of the use of recombinant human GH (rhGH) as a treatment for PWS.

Method: We performed a systematic review and, where possible, meta-analysis for the following outcomes: growth, body mass index, body composition, cognitive function, quality of life, head circumference, motor development/strength, behaviour and adverse effects. Read More

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http://dx.doi.org/10.1136/bmjpo-2019-000630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213882PMC

Diagnostic accuracy of clinical tests for cam or pincer morphology in individuals with suspected FAI syndrome: a systematic review.

BMJ Open Sport Exerc Med 2020 27;6(1):e000772. Epub 2020 Apr 27.

Physiotherapy, HES-SO Valais-Wallis, Leukerbad, Valais-Wallis, Switzerland.

Objectives: To determine the diagnostic accuracy of clinical tests for cam or pincer morphology in individuals with suspected femoroacetabular impingement (FAI) syndrome and to evaluate their clinical utility.

Design: A systematic review of studies investigating the diagnostic accuracy of clinical tests for cam and pincer morphology.

Data Sources: PubMed, Embase, CINAHL and SPORTDiscus. Read More

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http://dx.doi.org/10.1136/bmjsem-2020-000772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213881PMC

Effect of erythropoietin on athletic performance: a systematic review and meta-analysis.

BMJ Open Sport Exerc Med 2020 28;6(1):e000716. Epub 2020 Apr 28.

Ancaster Sports Medicine Centre, Ancaster, Ontario, Canada.

Introduction: Athletes have attempted to glean the ergogenic benefits of recombinant human erythropoietin (rHuEPO) since it became available in the 1980s. However, there is limited consensus in the literature regarding its true performance-enhancing effects. In fact, some studies suggest there is no conclusive evidence; therefore, it is necessary to evaluate and quantify the strength of the evidence. Read More

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http://dx.doi.org/10.1136/bmjsem-2019-000716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213874PMC

Building scale and well-being in a hospice: a qualitative exploration.

BMJ Support Palliat Care 2020 May 14. Epub 2020 May 14.

KU Leuven, Department of Architecture, Research[x]Design, Leuven, Belgium.

Objective: This study explored how built space plays out in palliative care, focusing on spatial aspects that could support or hamper patients', relatives' and caregivers' well-being.

Methods: This study was conducted in a freestanding small-scale hospice combining a residential part for eight guests with a day-care part for groups of about five persons. Observations were combined with semistructured, individual interviews with eight guests (sometimes accompanied by relatives) and three focus-group interviews with staff, volunteers and relatives. Read More

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http://dx.doi.org/10.1136/bmjspcare-2019-002151DOI Listing

Graduated compression stockings as adjuvant to pharmaco-thromboprophylaxis in elective surgical patients (GAPS study): randomised controlled trial.

BMJ 2020 May 13;369:m1309. Epub 2020 May 13.

Department of Surgery and Cancer, Imperial College London & Imperial Vascular Unit, Imperial College Healthcare NHS Trust, London W6 8RF, UK

Objectives: To investigate whether the use of graduated compression stockings (GCS) offers any adjuvant benefit when pharmaco-thromboprophylaxis is used for venous thromboembolism prophylaxis in patients undergoing elective surgery.

Design: Open, multicentre, randomised, controlled, non-inferiority trial.

Setting: Seven National Health Service tertiary hospitals in the United Kingdom. Read More

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http://dx.doi.org/10.1136/bmj.m1309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219517PMC

Cytoreductive surgery (CRS) with hyperthermic intraoperative peritoneal chemotherapy (HIPEC) versus standard of care (SoC) in people with peritoneal metastases from colorectal, ovarian or gastric origin: protocol for a systematic review and individual participant data (IPD) meta-analyses of effectiveness and cost-effectiveness.

BMJ Open 2020 May 12;10(5):e039314. Epub 2020 May 12.

Colorectal and Peritoneal Oncology Centre, The Christie NHS Foundation Trust, Manchester, UK.

Introduction: There is uncertainty about whether cytoreductive surgery (CRS)+hyperthermic intraoperative peritoneal chemotherapy (HIPEC) improves survival and/or quality of life compared with standard of care (SoC) in people with peritoneal metastases who can withstand major surgery.

Primary Objectives: To compare the relative benefits and harms of CRS+HIPEC versus SoC in people with peritoneal metastases from colorectal, ovarian or gastric cancers eligible to undergo CRS+HIPEC by a systematic review and individual participant data (IPD) meta-analysis.

Secondary Objectives: To compare the cost-effectiveness of CRS+HIPEC versus SoC from a National Health Service (NHS) and personal social services perspective using a model-based cost-utility analysis. Read More

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http://dx.doi.org/10.1136/bmjopen-2020-039314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228534PMC

Prediction of childhood brain outcomes in infants born preterm using neonatal MRI and concurrent clinical biomarkers (PREBO-6): study protocol for a prospective cohort study.

BMJ Open 2020 May 12;10(5):e036480. Epub 2020 May 12.

Consumer Representative, Brisbane, Queensland, Australia.

Introduction: Infants born very preterm are at risk of adverse neurodevelopmental outcomes, including cognitive deficits, motor impairments and cerebral palsy. Earlier identification enables targeted early interventions to be implemented with the aim of improving outcomes.

Methods And Analysis: Protocol for 6-year follow-up of two cohorts of infants born <31 weeks gestational age (PPREMO: Prediction of Preterm Motor Outcomes; PREBO: Prediction of Preterm Brain Outcomes) and a small term-born reference sample in Brisbane, Australia. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228524PMC

Prevalence and associated factors of preterm birth in Ethiopia: systematic review and meta-analysis protocol.

BMJ Open 2020 May 12;10(5):e035574. Epub 2020 May 12.

Reproductive Health, University of Gondar College of Medicine and Health Sciences, Gondar, Ethiopia.

Introduction: Preterm birth (PTB) complications are the leading cause of death among neonates globally. The reduction in neonatal mortality is not remarkable in Ethiopia. Therefore, this review will assess the magnitude and associated factors of PTB in Ethiopia. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228533PMC
May 2020
2.063 Impact Factor