162,828 results match your criteria BMC women\'s health[Journal]


Whole-body dual-energy X-ray absorptiometry demonstrates better reliability than segmental body composition analysis in college-aged students.

PLoS One 2019 22;14(4):e0215599. Epub 2019 Apr 22.

Application Centre BALUO, Faculty of Physical Culture, Palacký University, Olomouc, Czech Republic.

Dual-energy X-ray absorptiometry (DXA) is rapidly becoming more accessible and popular as a technique to monitor body composition. The reliability of DXA has been examined extensively using a number of different methodological approaches. This study sets up to investigate the accuracy of measuring the parameters of body composition (BC) by means of the whole-body and the segmental DXA method analysis with the typical error of measurement (TEM) that allows for expressing the error in the units of measure. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215599PLOS
April 2019
1 Read

The utility of ESR, CRP and platelets in the diagnosis of GCA.

BMC Rheumatol 2019 10;3:14. Epub 2019 Apr 10.

The Rheumatology Department, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville, SA 5011 Australia.

Background: To compare the utility of ESR, CRP and platelets for the diagnosis of GCA.

Method: A clinical diagnosis of GCA was determined by case-note review of 270 individuals (68% female, mean age 72 years) referred to a central pathology service for a temporal artery biopsy between 2011 and 2014. The highest levels of ESR, CRP and platelets (within 2 weeks of diagnosis) were documented. Read More

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http://dx.doi.org/10.1186/s41927-019-0061-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456976PMC

A Survey Identifying Nutritional Needs in a Contemporary Adult Cystic Fibrosis Cohort.

BMC Nutr 2019 7;5. Epub 2019 Jan 7.

Department of Medicine; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington School of Medicine, 1959 NE Pacific, Campus Box 356522, Seattle, WA, USA 98195-6522.

Background: Cystic fibrosis (CF) is a disease in which nutritional barriers are diverse and common, with malnutrition greatly influencing pulmonary trajectory and overall outcomes. Despite this, the most effective methods to optimize CF nutrition are unknown, and literature describing patients' perspectives on their specific nutritional needs is lacking, particularly in the modern era of CF care. This study aimed to identify the most important nutritional needs and desired health-improvement resources in a contemporary adult CF cohort. Read More

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http://dx.doi.org/10.1186/s40795-018-0266-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474380PMC
January 2019

Lower extremity critical limb ischemia: A review of clinical features and management.

Trends Cardiovasc Med 2019 Apr 15. Epub 2019 Apr 15.

Division of Vascular and Endovascular Surgery, Boston University School of Medicine, Boston Medical Center, 88 E. Newton Street C520, Boston, MA 02118, United States. Electronic address:

Lower extremity critical limb ischemia (CLI) represents symptoms related to end-stage atherosclerotic peripheral arterial disease manifested by rest pain and tissue loss. It is associated with increased risk of limb amputation and cardiovascular-related mortality. The prevalence and cost of CLI are expected to increase with both the aging of the U. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10501738193004
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http://dx.doi.org/10.1016/j.tcm.2019.04.002DOI Listing
April 2019
1 Read

Retrieval of a Very Large Foreign Body From the Bronchial Tree in an Intubated Patient.

Arch Bronconeumol 2019 Apr 16. Epub 2019 Apr 16.

Institute of Pulmonary Diseases, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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http://dx.doi.org/10.1016/j.arbres.2019.02.019DOI Listing

Genome-wide association studies of seven agronomic traits under two sowing conditions in bread wheat.

BMC Plant Biol 2019 Apr 17;19(1):149. Epub 2019 Apr 17.

Texas A&M Agrilife Research & Extension Center, Amarillo, TX, USA.

Background: Wheat is a cool seasoned crop requiring low temperature during grain filling duration and therefore increased temperature causes significant yield reduction. A set of 125 spring wheat genotypes from International Maize and Wheat Improvement Centre (CIMMYT-Mexico) was evaluated for phenological and yield related traits at three locations in Pakistan under normal sowing time and late sowing time for expose to prolonged high temperature. With the help of genome-wide association study using genotyping-by-sequencing, marker trait associations (MTAs) were observed separately for the traits under normal and late sown conditions. Read More

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http://dx.doi.org/10.1186/s12870-019-1754-6DOI Listing

Patient Satisfaction with Oral Versus Intravenous Sedation for Cataract Surgery : A Randomized Clinical Trial.

Ophthalmology 2019 Apr 16. Epub 2019 Apr 16.

Department of Ophthalmology, Boston Medical Center, Boston University School of Medicine, Boston, MA.

Purpose: To determine whether patient satisfaction with oral sedation is non-inferior to intravenous (IV) sedation for cataract surgery.

Design: A prospective, randomized, double-masked clinical trial.

Subjects: A volunteer sample of patients age 18 or older from diverse ethnic, racial, and socioeconomic backgrounds scheduled for cataract surgery. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.04.022DOI Listing

Correction to: Consent requirements for research with human tissue: Swiss ethics committee members disagree.

BMC Med Ethics 2019 Apr 18;20(1):24. Epub 2019 Apr 18.

Institute for Biomedical Ethics, Bernoullistrasse 28, 4055, Basel, Switzerland.

It has come to our attention that in the original article [1] information regarding dates was omitted. The data in this study were obtained in Switzerland four years before the entering into force of the new Swiss Human Research Act in 2014, when the guidelines of the Swiss Academy of Medical Sciences (SAMS) ceased to apply. It is important for readers to know that at the time of the study there was no binding law in Switzerland, only the more open SAMS guidelines that have a different legal status. Read More

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http://dx.doi.org/10.1186/s12910-019-0365-yDOI Listing

Long-term peritoneal dialysis followed by kidney transplantation for Takayasu arteritis: a case report.

BMC Nephrol 2019 Apr 18;20(1):131. Epub 2019 Apr 18.

Division of Nephrology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan.

Background: Takayasu arteritis (TA) is a chronic vasculitis of unknown etiology that primarily affects large vessels. Although renal involvement is frequent in TA, patients with TA undergoing renal replacement therapy, especially long-term peritoneal dialysis (PD) and kidney transplantation (KTx), are rarely reported. We herein present the case of an elderly patient with TA treated by PD for more than 5 years and underwent KTx thereafter. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1302-5DOI Listing
April 2019
4 Reads

Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.

BMC Cancer 2019 04 18;19(1):366. Epub 2019 Apr 18.

Universitätsklinikum Schleswig-Holstein, Schittenhelmstr, 7, D-24 105, Kiel, Germany.

Following publication of the original article [1], it was reported that the legend for Fig. 1 was incomplete. The complete figure legend is. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5568-6DOI Listing
April 2019
1 Read

Imaging biomarkers for well and moderate hepatocellular carcinoma: preoperative magnetic resonance image and histopathological correlation.

BMC Cancer 2019 Apr 18;19(1):364. Epub 2019 Apr 18.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China.

Background: Our aim of the study is to investigate the feasibility of preoperative prediction for hepatocellular carcinoma (HCC) histological grading using gadoxetic acid-enhanced magnetic resonance imaging (MRI).

Methods: This study included one hundred and fifty-six patients with solitary HCC. Preoperative gadoxetic acid-enhanced MRI findings were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s12885-019-5574-8DOI Listing

Predictors associated with HIV/AIDS patients dropout from antiretroviral therapy at Mettu Karl Hospital, southwest Ethiopia.

Authors:
Melaku Tadege

BMC Res Notes 2019 Apr 18;12(1):232. Epub 2019 Apr 18.

Department of Statistics, Injibara University, Injibara, Amhara, Ethiopia.

Objective: The aim of this study was to determine the major risk factors of antiretroviral therapy dropout. The retrospective cohort research design was applied. 1512 HIV patients were included from Mettu Karl Hospital in Illubabor Zone, southwest part of Ethiopia from September 2005 to January 2018. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4267-3DOI Listing
April 2019
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Identifying clinically important COPD sub-types using data-driven approaches in primary care population based electronic health records.

BMC Med Inform Decis Mak 2019 Apr 18;19(1):86. Epub 2019 Apr 18.

Institute of Health Informatics, University College London, 222 Euston Road, London, NW1 2DA, UK.

Background: COPD is a highly heterogeneous disease composed of different phenotypes with different aetiological and prognostic profiles and current classification systems do not fully capture this heterogeneity. In this study we sought to discover, describe and validate COPD subtypes using cluster analysis on data derived from electronic health records.

Methods: We applied two unsupervised learning algorithms (k-means and hierarchical clustering) in 30,961 current and former smokers diagnosed with COPD, using linked national structured electronic health records in England available through the CALIBER resource. Read More

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http://dx.doi.org/10.1186/s12911-019-0805-0DOI Listing

Student motivation to learn: is self-belief the key to transition and first year performance in an undergraduate health professions program?

BMC Med Educ 2019 Apr 18;19(1):111. Epub 2019 Apr 18.

Faculty of Health and Medical Sciences, The University of Western Australia, 35 Stirling Hwy, Nedlands, Western Australia, 6009, Australia.

Background: Student motivation to learn has been undervalued to date though has been identified as an area influencing student success and retention at university. The transition into university has been highlighted as a key period affecting student outcomes as well as well-being. Early identification of those students at risk may assist the transition for many students moving into higher education. Read More

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https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909
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http://dx.doi.org/10.1186/s12909-019-1539-5DOI Listing
April 2019
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Tuberculosis care for migrant patients in Portugal: a mixed methods study with primary healthcare providers.

BMC Health Serv Res 2019 Apr 18;19(1):233. Epub 2019 Apr 18.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisbon, Portugal.

Background: Tuberculosis (TB) is still a major global health problem. The increasing number of cases observed among foreign-born populations contrasts with the decreasing trends observed in later years in some high-income countries. Healthcare providers are key interveners in the control of TB and HIV-TB infections. Read More

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http://dx.doi.org/10.1186/s12913-019-4050-0DOI Listing

Challenges in a six-phase process of questionnaire adaptation: findings from the French translation of the Integrated Palliative care Outcome Scale.

BMC Palliat Care 2019 Apr 18;18(1):38. Epub 2019 Apr 18.

Palliative and supportive care service, Lausanne University Hospital and University of Lausanne, Avenue Pierre-Decker 5, 1011, Lausanne, Switzerland.

Background: The Integrated Palliative care Outcome Scale (IPOS) was developed for evaluating essential outcomes for palliative care patients. Our objectives here are to describe the process of a six-phase cross-cultural adaptation of IPOS to French (IPOS-Fr), highlight the difficulties encountered and strategies to solve them, and discuss the implications that adaptation may have on the validity and reliability of a questionnaire.

Methods: The adaptation of IPOS consisted of six phases: (i) literature review and interviews with target population; (ii) forward translation to French; (iii) backward translation to English; (iv) Expert Review; (v) cognitive interviews with target population; (vi) final review. Read More

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http://dx.doi.org/10.1186/s12904-019-0422-9DOI Listing

Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions.

BMC Biol 2019 Apr 18;17(1):35. Epub 2019 Apr 18.

Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, Discipline of Biological Sciences, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia.

Background: The mammalian epididymis is responsible for the provision of a highly specialized environment in which spermatozoa acquire functional maturity and are subsequently stored in preparation for ejaculation. Making important contributions to both processes are epididymosomes, small extracellular vesicles released from the epididymal soma via an apocrine secretory pathway. While considerable effort has been focused on defining the cargo transferred between epididymosomes and spermatozoa, comparatively less is known about the mechanistic basis of these interactions. Read More

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http://dx.doi.org/10.1186/s12915-019-0653-5DOI Listing
April 2019
2 Reads
7.984 Impact Factor

Impact of polyols on Oral microbiome of Estonian schoolchildren.

BMC Oral Health 2019 Apr 18;19(1):60. Epub 2019 Apr 18.

Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

Background: Oral microbiome has significant impact on both oral and general health. Polyols have been promoted as sugar substitutes in prevention of oral diseases. We aimed to reveal the effect of candies containing erythritol, xylitol or control (sorbitol) on salivary microbiome. Read More

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https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12903-019-0747-zDOI Listing
April 2019
1 Read

Time for a reassessment of the treatment of hypothyroidism.

BMC Endocr Disord 2019 Apr 18;19(1):37. Epub 2019 Apr 18.

, 113 Andersons Road, Yandina, QLD 4561, Australia.

Background: In the treatment for hypothyroidism, a historically symptom-orientated approach has given way to reliance on a single biochemical parameter, thyroid stimulating hormone (TSH).

Main Body: The historical developments and motivation leading to that decision and its potential implications are explored from pathophysiological, clinical and statistical viewpoints. An increasing frequency of hypothyroid-like complaints is noted in patients in the wake of this directional shift, together with relaxation of treatment targets. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-019-0365-4DOI Listing
April 2019
1 Read

The pain colour of children with toothache in Turkish population.

BMC Oral Health 2019 Apr 18;19(1):59. Epub 2019 Apr 18.

Department of General Surgery, Gaziosmanpaşa University, Faculty of Medicine, Tokat, Turkey.

Background: Toothache is a common consequence of untreated caries, predisposed by poor oral hygiene and high caries risk. Most children expressed their pain through their parents or carers. The aim of this study was to determine the colour of pain presence and absence. Read More

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http://dx.doi.org/10.1186/s12903-019-0756-yDOI Listing

Efficiency of chewable toothbrush in reduction of dental plaque in students.

BMC Oral Health 2019 Apr 18;19(1):58. Epub 2019 Apr 18.

Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia.

Background: Besides classical and electrical toothbrushes market offers tooth brushes that can be chewed, like chewing gums. The aim of this study was to show the effectiveness of chewable toothbrush versus a conventional brush in the students' population.

Methods: The prospective study included 346 students. Read More

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http://dx.doi.org/10.1186/s12903-019-0748-yDOI Listing

Characterization of putative proteins encoded by variable ORFs in white spot syndrome virus genome.

BMC Struct Biol 2019 Apr 18;19(1). Epub 2019 Apr 18.

Applied Molecular Biology Lab - LAPLIC, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Background: White Spot Syndrome Virus (WSSV) is an enveloped double-stranded DNA virus which causes mortality of several species of shrimp, being considered one of the main pathogens that affects global shrimp farming. This virus presents a complex genome of ~ 300 kb and viral isolates that present genomes with great identity. Despite this conservation, some variable regions in the WSSV genome occur in coding regions, and these putative proteins may have some relationship with viral adaptation and virulence mechanisms. Read More

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http://dx.doi.org/10.1186/s12900-019-0106-yDOI Listing

Invasive Salmonella infections among children in Bintulu, Sarawak, Malaysian Borneo: a 6-year retrospective review.

BMC Infect Dis 2019 Apr 18;19(1):330. Epub 2019 Apr 18.

Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.

Background: Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3963-xDOI Listing
April 2019
1 Read

Post traumatic stress disorder and coping strategies among adult survivors of earthquake, Nepal.

BMC Psychiatry 2019 Apr 18;19(1):118. Epub 2019 Apr 18.

Gandaki Medical College Teaching Hospital and Research Centre, Tribhuvan University, Pokhara, Nepal.

Background: Post traumatic stress disorder (PTSD) is the most frequently reported psychiatric morbidity among the survivors of natural disasters. It is the main hindrance to rehabilitate their life. However its prevalence particularly in Nepal is largely unknown. Read More

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https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12888-019-2090-yDOI Listing
April 2019
1 Read

S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1.

BMC Nephrol 2019 Apr 18;20(1):135. Epub 2019 Apr 18.

Center for Experimental Medical Research, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, Hunan, 410013, People's Republic of China.

Aims: Sphingosine-1-phosphate receptor 2 (S1PR2) is a G-protein-coupled receptor that regulates sphingosine-1-phosphate-triggered cellular response. However, the role of S1PR2 in diabetes-induced glomerular endothelial cell dysfunction remains unclear. This study aims to investigate the effect of S1PR2 blockade on the morphology and function of mitochondria in human renal glomerular endothelial cells (HRGECs). Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1323-0DOI Listing
April 2019
1 Read

Association between anxiety and aggression in adolescents: a cross-sectional study.

BMC Pediatr 2019 Apr 18;19(1):115. Epub 2019 Apr 18.

College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul, 03760, South Korea.

Background: The purpose of this study was to investigate the relationship between anxiety proneness and aggressive behavior in adolescents.

Methods: A quantitative, large scale cross-sectional study was conducted in Korea. The survey questionnaire included general health behavior and scales for assessing anxiety (Revised Children's Manifest Anxiety Scale; RCMAS) and aggressive behavior (The Aggression Questionnaire; AQ) in adolescents. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1479-6DOI Listing
April 2019
1 Read

Religiosity and sexual abstinence among Nigerian youths: does parent religion matter?

BMC Public Health 2019 Apr 18;19(1):416. Epub 2019 Apr 18.

Demography and Population Studies Programme, Schools of Public Health and Social Sciences, Faculties of Health Sciences and Humanities, University of the Witwatersrand, Johannesburg, South Africa.

Background: Religion plays an important role in youth behaviours, making it a significant factor in the discourse on youth sexuality in sub-Saharan Africa. Several studies have found that religion and religiosity play an important role in the sexual behaviours of young people. However, little research in Nigeria has examined the mechanisms through which religiosity influences youth sexual behaviour and if parents' religion moderates this relationship. Read More

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http://dx.doi.org/10.1186/s12889-019-6732-2DOI Listing

Intravitreal dexamethasone implant for central retinal vein occlusion without macular edema.

BMC Ophthalmol 2019 Apr 17;19(1):92. Epub 2019 Apr 17.

Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonjuro, Gangnam-gu, Seoul, 06273, South Korea.

Background: To evaluate the efficacy of an intravitreal dexamethasone (IVD) implant (Ozurdex®) for the treatment of central retinal vein occlusion (CRVO) without macular edema (ME).

Methods: A retrospective cohort study was designed, and 20 eyes of 20 patients diagnosed with non-ischemic CRVO without ME were included. A total of 10 CRVO eyes were observed without treatment, and another 10 CRVO eyes received a single IVD injection at baseline. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-019-1097-yDOI Listing
April 2019
2 Reads

Glucose screening within six months postpartum among Chinese mothers with a history of gestational diabetes mellitus: a prospective cohort study.

BMC Pregnancy Childbirth 2019 Apr 18;19(1):134. Epub 2019 Apr 18.

Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.

Background: Gestational diabetes mellitus (GDM) is a risk factor for diabetes mellitus. The 75-g, 2-h oral glucose tolerance test is recommended for mothers with a history of GDM to screen for diabetes in the postnatal period. The aim of this study was to investigate the rate of glucose screening within 6 months postpartum among Chinese mothers with a history of GDM, and to identify its predictors. Read More

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http://dx.doi.org/10.1186/s12884-019-2276-9DOI Listing

Associations of serum and dialysate electrolytes with QT interval and prolongation in incident hemodialysis: the Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease (PACE) study.

BMC Nephrol 2019 Apr 18;20(1):133. Epub 2019 Apr 18.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Prolonged QT interval in hemodialysis patients may be associated with sudden cardiac death, however, few studies examined the longitudinal associations of modifiable factors such as serum and dialysate concentrations of calcium, potassium, and magnesium with corrected QT (QTc) prolongation in incident hemodialysis patients.

Methods: In 330 in-center hemodialysis participants from the PACE study who were followed up for one year, we examined the associations of predialysis serum electrolytes (total calcium [Ca], corrected Ca [cCa], ionized Ca [iCa], potassium [K], magnesium [Mg]), dialysate (dCa and dK), and serum-to-dialysate gradient measures with QTc interval and prolongation (≥460 ms in women and ≥ 450 ms in men).

Results: At the first study visit, 47% had QTc prolongation. Read More

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http://dx.doi.org/10.1186/s12882-019-1282-5DOI Listing
April 2019
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Improving proteinuria screening with mailed smartphone urinalysis testing in previously unscreened patients with hypertension: a randomized controlled trial.

BMC Nephrol 2019 Apr 18;20(1):132. Epub 2019 Apr 18.

Geisinger Health System, Department of Nephrology, 100 N Academy Ave, Danville, PA17822, USA.

Background: Proteinuria screening is recommended for patients with hypertension to screen for kidney disease and identify those at elevated risk for cardiovascular disease. However, screening rates among hypertensive patients are low. Home testing strategies may be useful in improving proteinuria screening adherence. Read More

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http://dx.doi.org/10.1186/s12882-019-1324-zDOI Listing

Characterisation of three novel α-L-arabinofuranosidases from a compost metagenome.

BMC Biotechnol 2019 Apr 18;19(1):22. Epub 2019 Apr 18.

Institute for Microbial Biotechnology and Metagenomics, University of the Western Cape, Bellville, South Africa.

Background: The importance of the accessory enzymes such as α-L-arabinofuranosidases (AFases) in synergistic interactions within cellulolytic mixtures has introduced a paradigm shift in the search for hydrolytic enzymes. The aim of this study was to characterize novel AFase genes encoding enzymes with differing temperature optima and thermostabilities for use in hydrolytic cocktails.

Results: Three fosmids, pFos-H4, E3 and D3 were selected from the cloned metagenome of high temperature compost, expressed in Escherichia coli and subsequently purified to homogeneity from cell lysate. Read More

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http://dx.doi.org/10.1186/s12896-019-0510-1DOI Listing

NAV-KIDS trial: protocol for a multi-centre, staggered randomised controlled trial of a patient navigator intervention in children with chronic kidney disease.

BMC Nephrol 2019 Apr 18;20(1):134. Epub 2019 Apr 18.

Centre for Kidney Research at The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Background: Chronic kidney disease (CKD) is a devastating illness associated with increased mortality, reduced quality of life, impaired growth, neurocognitive impairment and psychosocial maladjustment in children. There is growing evidence of socioeconomic disparities in health outcomes among children with CKD. Patient navigators are trained non-medical personnel who assist patients with chronic conditions journey through the continuum of care and transit across different care settings. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1325-yDOI Listing
April 2019
2 Reads

Digenetic inheritance of SLC12A3 and CLCNKB genes in a Chinese girl with Gitelman syndrome.

BMC Pediatr 2019 Apr 18;19(1):114. Epub 2019 Apr 18.

The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Background: Gitelman syndrome (GS) is an autosomal recessive disorder and mild variant of classic Bartter syndrome. The latter is caused by defects in the genes CLCNKB and/or CLCNKA (chloride voltage-gated channel Ka and Kb). Patients with GS usually have loss-of-function mutations in SLC12A3. Read More

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http://dx.doi.org/10.1186/s12887-019-1498-3DOI Listing
April 2019
2 Reads

Do trajectories of economic, work- and health-related disadvantages explain child welfare clients' increased mortality risk? A prospective cohort study.

BMC Public Health 2019 Apr 18;19(1):418. Epub 2019 Apr 18.

Department of Social Work, Stockholm University, SE-106 91, Stockholm, Sweden.

Background: Past research has shown that individuals who have had experiences of out-of-home care (OHC) in childhood have increased risks of premature mortality. Prior studies also suggest that these individuals are more likely to follow long-term trajectories that are characterised by economic, work-, and health-related disadvantages, compared to majority population peers. Yet, we do not know the extent to which such trajectories may explain their elevated mortality risks. Read More

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http://dx.doi.org/10.1186/s12889-019-6752-yDOI Listing

Improving nutrition and physical activity environments of family child care homes: the rationale, design and study protocol of the 'Healthy Start/Comienzos Sanos' cluster randomized trial.

BMC Public Health 2019 Apr 18;19(1):419. Epub 2019 Apr 18.

Center for Health Equity Research, Brown University School of Public Health, Providence, RI, 02912, USA.

Background: Early childhood is a crucial time to foster healthy eating and physical activity (PA) habits, which are critical for optimal child health, growth and development. Child care facilities are important settings to promote healthy eating and PA and prevent childhood obesity; however, almost all prior intervention studies have focused on child care centers and not family child care homes (FCCH), which care for over 1.6 million U. Read More

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http://dx.doi.org/10.1186/s12889-019-6704-6DOI Listing
April 2019
1 Read

Vitamin K deficiency-induced hemorrhagic shock after thoracentesis: a case report.

BMC Gastroenterol 2019 Apr 18;19(1):58. Epub 2019 Apr 18.

Honjoudaiichi Hospital, 110, Iwabuchishita, Yurihonnjou, Akita, 015-8567, Japan.

Background: Vitamin K deficiency results in serious coagulation dysfunction, but hemorrhagic shock is rare. Herein, we describe a case of vitamin K deficiency and abnormality in the path of the intercostal artery, the combination of which led to hemorrhagic shock.

Case Presentation: An 83-year-old woman was hospitalized for suspected gallstones. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0978-0DOI Listing
April 2019
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The double-edged sword - prosthetic joint infection following BCG treatment for bladder cancer: a case report.

BMC Infect Dis 2019 Apr 18;19(1):331. Epub 2019 Apr 18.

Department of Medical Microbiology and Immunology, University of California - Davis, University of California Davis Medical Center, Sacramento, CA, USA.

Background: Prosthetic joint infections remain a significant cause of morbidity and are frustrating for patients and physicians alike. Unusual causes of infection may be seen in selected circumstances and a high index of suspicion and a careful history are required to ensure an accurate and timely diagnosis can be made.

Case Presentation: We present a case of Mycobacterium bovis prosthetic joint infection secondary to intravesicular Bacillus Calmette-Guérin (BCG) treatment for prior bladder cancer definitively identified by spoligotyping. Read More

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http://dx.doi.org/10.1186/s12879-019-3951-1DOI Listing

Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis.

BMC Pulm Med 2019 Apr 18;19(1):81. Epub 2019 Apr 18.

Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: In many clinical disorders, there is a relationship between the ratio of the diameter of the main pulmonary artery (mPA) to that of the aorta (Ao) on chest computed tomography (CT). The aim of this study was to determine if the mPA/Ao ratio at diagnosis is associated with the clinical characteristics and outcomes in patients with idiopathic pulmonary fibrosis (IPF).

Methods: We retrospectively reviewed the diameters of the pulmonary artery and aorta on chest CT, clinical characteristics, and results of other examinations in 303 patients at the time of initial diagnosis of IPF at our tertiary care center between 2011 and 2015. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-019-0843-5DOI Listing
April 2019
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Outcome prediction in disorders of consciousness: the role of coma recovery scale revised.

BMC Neurol 2019 Apr 18;19(1):68. Epub 2019 Apr 18.

S. Anna Institute and Research in Advanced Neurorehabilitation (RAN), 88900, Crotone, Italy.

Background: To evaluate the utility of the revised coma remission scale (CRS-r), together with other clinical variables, in predicting emergence from disorders of consciousness (DoC) during intensive rehabilitation care.

Methods: Data were retrospectively extracted from the medical records of patients enrolled in a specialized intensive rehabilitation unit. 123 patients in a vegetative state (VS) and 57 in a minimally conscious state (MCS) were included and followed for a period of 8 weeks. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1293-7DOI Listing
April 2019
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Motivations and experiences of volunteers and patients in mental health befriending: a thematic analysis.

BMC Psychiatry 2019 Apr 17;19(1):116. Epub 2019 Apr 17.

Unit for Social and Community Psychiatry, WHO Collaborating Centre for Mental Health Services Development, Newham Centre for Mental Health, Glen Road, London, E13 8SP, UK.

Background: Volunteers frequently participate in befriending schemes with people with mental illness. This study aimed to explore the motivations and experiences of volunteer befrienders engaging in these schemes in addition to the experiences of befriending recipients.

Methods: Semi-structured interviews were conducted with 38 volunteers and 23 befriending recipients, across 12 mental health befriending schemes in the UK, and analysed using Thematic Analysis. Read More

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http://dx.doi.org/10.1186/s12888-019-2102-yDOI Listing

Differential proteomic comparison of breast cancer secretome using a quantitative paired analysis workflow.

BMC Cancer 2019 Apr 18;19(1):365. Epub 2019 Apr 18.

Laboratory of Toxinology, Oswaldo Cruz Institute, Fiocruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, 21040-360, Brazil.

Background: Worldwide, breast cancer is the main cause of cancer mortality in women. Most cases originate in mammary ductal cells that produce the nipple aspirate fluid (NAF). In cancer patients, this secretome contains proteins associated with the tumor microenvironment. Read More

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http://dx.doi.org/10.1186/s12885-019-5547-yDOI Listing

Direct-acting antivirals and visceral leishmaniasis: a case report.

BMC Infect Dis 2019 Apr 18;19(1):328. Epub 2019 Apr 18.

Dipartimento di Scienze per la promozione della Salute e Materno-infantile, Università di Palermo, Palermo, Italy.

Background: Visceral leishmaniasis is a vector-borne parasitic disease caused by protozoa belonging to the genus Leishmania. The clinical presentation of visceral leishmaniasis strictly depends on the host immunocompetency, whereas depressive conditions of the immune system impair the capability to resolve the infection and allow reactivation from sites of latency of the parasite.

Case Presentation: We describe a case of visceral leishmaniasis (VL) that occurred in a patient with chronic hepatitis C treated with direct-acting antiviral drugs (DAA). Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3947-xDOI Listing
April 2019
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Parental smoking and blood pressure in children and adolescents: a national cross-sectional study in China.

BMC Pediatr 2019 Apr 18;19(1):116. Epub 2019 Apr 18.

Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, Xueyuan Road 38, Haidian District, Beijing, 100191, China.

Background: Current evidence on the health effects of passive smoking on childhood blood pressure is limited and inconsistent. We investigated the associations between exposure to parental smoking and blood pressure in children and adolescents.

Methods: A cross-sectional analysis was performed in a national sample of 42,745 children and adolescents (50. Read More

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http://dx.doi.org/10.1186/s12887-019-1505-8DOI Listing

Factors associated with alcohol consumption and prescribed drugs with addiction potential among older women and men - the Nord-Trøndelag health study (HUNT2 and HUNT3), Norway, a population-based longitudinal study.

BMC Geriatr 2019 Apr 18;19(1):113. Epub 2019 Apr 18.

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Background: Little is known about factors associated with alcohol consumption and use of drugs with addiction potential in older adults. The aim of this study was to explore the association between socio-demographic variables, physical and mental health and the later (11 years) use of frequent drinking, prescribed drugs with addiction potential and the possible combination of frequent drinking and being prescribed drugs with addiction potential in older adults (≥ 65 years).

Methods: In this longitudinal study, we used data from two surveys of the Nord-Trøndelag Health Study (HUNT2 1995-1997 and HUNT3 2006-2008), a population based study in Norway. Read More

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https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877
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http://dx.doi.org/10.1186/s12877-019-1114-2DOI Listing
April 2019
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Prognosis and risk factors of patients with upper urinary tract urothelial carcinoma and postoperative recurrence of bladder cancer in central China.

BMC Urol 2019 Apr 18;19(1):24. Epub 2019 Apr 18.

Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Background: To investigate the prognostic risk factors and postoperative recurrence of bladder cancer in patients with upper urinary tract urothelial carcinomas (UTUCs).

Methods: Data of 439 UTUC patients were retrospectively analyzed. Follow-up and analysis of smoking effects, consumption of traditional Chinese medicine containing aristolochic acid, history of bladder cancer, age, sex, presence or absence of diabetes mellitus (DM), metformin use, tumor characteristics (number, location, stage, grade), and open or laparoscopic surgery on the prognosis of UTUCs were performed. Read More

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http://dx.doi.org/10.1186/s12894-019-0457-5DOI Listing

Rationale and methods of the MOVI-da10! Study -a cluster-randomized controlled trial of the impact of classroom-based physical activity programs on children's adiposity, cognition and motor competence.

BMC Public Health 2019 Apr 18;19(1):417. Epub 2019 Apr 18.

Universidad de Castilla-La Mancha, Social and Health Care Research Center, C/ Santa Teresa Jornet s/n, 16071, Cuenca, Spain.

Background: Although physical activity (PA) integrated in schools' classrooms have shown a positive effect on children's behaviors, its effectiveness on cognitive functions, PA levels and other health variables remains unclear. This article outlines the rationale and methods of two classroom-based PA interventions (MOVI-da10!) on improving adiposity, executive function and motor competence in preschool children.

Methods: A three-arm cluster-randomized controlled trial (RCT) was carried out including eight schools (rural and urban areas) from Cuenca province, Spain. Read More

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http://dx.doi.org/10.1186/s12889-019-6742-0DOI Listing

Sero-epidemiological status and risk factors of toxoplasmosis in pregnant women in Northern Vietnam.

BMC Infect Dis 2019 Apr 18;19(1):329. Epub 2019 Apr 18.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

Background: In Vietnam, few studies have determined the epidemiological status of toxoplasmosis in pregnant women and no routine prenatal screening is in place. This study was conducted to evaluate the seroprevalence of this zoonotic parasitic infection in pregnant women in Northern Vietnam and to assess the association with awareness, risk factors and congenital toxoplasmosis.

Methods: Approximately 800 pregnant women were included in the study from two hospitals, one in Hanoi and one in Thai Binh province, which is known to have a dense cat population. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3885-7DOI Listing
April 2019
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The impact of the adoption of a patient rostering model on primary care access and continuity of care in urban family practices in Ontario, Canada.

BMC Fam Pract 2019 Apr 18;20(1):52. Epub 2019 Apr 18.

Department of Public Health Sciences, Queen's University, 62 Fifth Field Company Lane, Kingston, ON, K7L 3N6, Canada.

Background: Greater continuity and access to primary care results in improved patient health, satisfaction, and reduced healthcare costs. Although patient rostering is considered to be a cornerstone of a high performing primary care system and is believed to improve continuity and access, few studies have examined these relationships. This study examined the impact of the adoption of a patient rostering enhanced fee-for-service model (eFFS) on continuity, coordination of specialized care, and access. Read More

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http://dx.doi.org/10.1186/s12875-019-0942-7DOI Listing