126 results match your criteria BMC rheumatology[Journal]


First-year drug therapy of new-onset rheumatoid and undifferentiated arthritis: a nationwide register-based study.

BMC Rheumatol 2020 3;4:34. Epub 2020 Jul 3.

Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland.

Background: In this retrospective cohort study, we evaluated the drug therapies used for early rheumatoid (RA) and undifferentiated (UA) arthritis patients.

Methods: From a nationwide register maintained by the Social Insurance Institution, information on sex, date of birth, and date of special medicine reimbursement decision for all new Finnish RA and UA patients between 2011 and 14 were collected, and their DMARD (Disease Modifying Antirheumatic Drug) purchases during the first year after the diagnosis were analyzed.

Results: A total of 7338 patients with early RA (67. Read More

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http://dx.doi.org/10.1186/s41927-020-00127-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333434PMC

Patient-Initiated Follow-Up (PIFU) as reorganized support for increased patient involvement - focus group discussions among patients' with inflammatory arthritis.

BMC Rheumatol 2020 30;4:44. Epub 2020 Jun 30.

Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.

Background: Inflammatory Arthritis is characterized by lifelong medical treatment and an unpredictable trajectory because of the fluctuating nature of the diseases. Proactive disease management is recommended, which includes close monitoring of disease activity that traditionally has been ensured by outpatient visits to rheumatologists at various fixed intervals. Internationally, there is a growing interest in how healthcare systems can be more flexible, individual-oriented and increasingly involve patients with lifelong diseases in their own treatment and care. Read More

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http://dx.doi.org/10.1186/s41927-020-00143-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325086PMC

Initial seronegative immune-mediated necrotising myopathy with subsequent anti-HMGCR antibody development and response to rituximab: case report.

BMC Rheumatol 2020 30;4:29. Epub 2020 Jun 30.

Department of Neurology, Royal London Hospital, Barts Health NHS Trust, London, UK.

Background: Immune-mediated necrotising myopathy (IMNM) is characterised by severe muscle weakness and necrosis with a paucity of inflammation on muscle biopsy. Around 60% of cases are associated with antibodies to the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR); the remainder are seronegative. IMNM is more treatment resistant than inflammatory myopathies. Read More

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http://dx.doi.org/10.1186/s41927-020-00128-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325302PMC

Points to consider in cardiovascular disease risk management among patients with rheumatoid arthritis living in South Africa, an unequal middle income country.

BMC Rheumatol 2020 16;4:42. Epub 2020 Jun 16.

Rheumatology Department, Charlotte Maxeke Johannesburg Academic Hospital, Faculty of Health Sciences, University of Witwatersrand, 80 Scholtz Road, Norwood, Johannesburg, 2190 South Africa.

Background: It is plausible that optimal cardiovascular disease (CVD) risk management differs in patients with rheumatoid arthritis (RA) from low or middle income compared to high income populations. This study aimed at producing evidence-based points to consider for CVD prevention in South African RA patients.

Methods: Five rheumatologists, one cardiologist and one epidemiologist with experience in CVD risk management in RA patients, as well as two patient representatives, two health professionals and one radiologist, one rheumatology fellow and 11 rheumatologists that treat RA patients regularly contributed. Read More

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http://dx.doi.org/10.1186/s41927-020-00139-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296622PMC

Real-world questions and concerns about disease-modifying antirheumatic drugs (DMARDs): a retrospective analysis of questions to a medicine call center.

BMC Rheumatol 2020 16;4:27. Epub 2020 Jun 16.

School of Pharmacy, The University of Queensland, 20 Cornwall St, Woolloongabba, QLD 4102 Australia.

Background: Disease-modifying antirheumatic drugs (DMARDs) have transformed the treatment of numerous autoimmune and inflammatory diseases but their perceived risk of harm may be a barrier to use.

Methods: In a retrospective mixed-methods study, we analysed conventional (c) and biologic (b) DMARDs-related calls and compared them with rest of calls (ROC) from consumers to an Australian national medicine call center operated by clinical pharmacists from September 2002 to June 2010. This includes the period where bDMARDs became available on the Pharmaceutical Benefits Scheme, the government-subsidized prescription medicines formulary. Read More

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http://dx.doi.org/10.1186/s41927-020-00126-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296694PMC

MicroRNA and mRNA profiling in the idiopathic inflammatory myopathies.

BMC Rheumatol 2020 10;4:25. Epub 2020 Jun 10.

Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

Background: The idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune conditions of skeletal muscle inflammation and weakness. MicroRNAs (miRNAs) are short, non-coding RNA which regulate gene expression of target mRNAs. The aim of this study was to profile miRNA and mRNA in IIM and identify miRNA-mRNA relationships which may be relevant to disease. Read More

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http://dx.doi.org/10.1186/s41927-020-00125-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285612PMC

Comparative evaluation of efficacy, pharmacodynamics, and safety of Hetero's adalimumab (Mabura®, Hetero Biopharma Ltd.) and reference adalimumab (Humira®, Abbvie Inc.) in patients with active rheumatoid arthritis on concomitant methotrexate therapy.

BMC Rheumatol 2020 4;4:24. Epub 2020 Jun 4.

Sapthagiri Institute of Medical Sciences and Research Center #15, Chikkasandra, Hesaraghatta Main Road, Bangalore, Karnataka 560090 India.

Background: Our study aimed to compare efficacy and safety of Hetero's adalimumab (Mabura®, Hetero Biopharma Limited) versus reference adalimumab (Humira®, Abbvie Inc.) in Indian patients with active rheumatoid arthritis (RA) concomitant on methotrexate (MTX) therapy.

Methods: Patients ( = 168) were randomized (2:1) to receive either test or reference product for 24 weeks with concomitant MTX. Read More

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http://dx.doi.org/10.1186/s41927-020-00124-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271501PMC

The role of advanced MRI in the development of treat-to-target therapeutic strategies, patient stratification and phenotyping in rheumatoid arthritis.

BMC Rheumatol 2020 28;4:33. Epub 2020 May 28.

IAG, Image Analysis Group, London, UK.

In this commentary, we discuss the potential of advanced imaging, particularly Dynamic Contrast Enhanced (DCE) magnetic resonance imaging (MRI) for the objective assessment of the inflammatory process in rheumatoid arthritis (RA). We emphasise the potential of DCE-MRI in advancing the field and exploring new areas of research and development in RA. We hypothesize that different grades of bone marrow edema (BME) and synovitis in RA can be examined and monitored in a more sensitive manner with DCE-MRI. Read More

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http://dx.doi.org/10.1186/s41927-020-00131-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254652PMC

Barriers and facilitators for screening and treatment of hyperlipidemia among patients with inflammatory arthritis.

BMC Rheumatol 2020 2;4:26. Epub 2020 Jun 2.

Weill Department of Medicine, Division of General Internal Medicine, Weill Cornell Medicine, 420 East 70yth Street - LH -363, New York, NY 10021 USA.

Background: Patients with inflammatory arthritis (IA), defined as rheumatoid arthritis (RA) and psoriatic arthritis (PsA), are at increased risk for cardiovascular disease (CVD). The frequency of screening and treatment of hyperlipidemia, a modifiable CVD risk factor, is low in these patients. The reasons for low screening and treatment rates in this population are poorly understood. Read More

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http://dx.doi.org/10.1186/s41927-020-00123-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265623PMC

Characterization of the interleukin-17 effect on articular cartilage in a translational model: an explorative study.

BMC Rheumatol 2020 12;4:30. Epub 2020 May 12.

2Rheumatology and Molecular Skeletal Biology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Background: Osteoarthritis (OA) is a progressive, chronic disease characterized by articular cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported elevated in serum and synovial fluid of OA patients and correlated with increased cartilage defects and bone remodeling. The aim of this study was to characterize an IL-17-mediated articular cartilage degradation ex-vivo model and to investigate IL-17 effect on cartilage extracellular matrix protein turnover. Read More

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http://dx.doi.org/10.1186/s41927-020-00122-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216541PMC

The utility of dual energy computed tomography in the management of axial gout: case reports and literature review.

BMC Rheumatol 2020 8;4:22. Epub 2020 May 8.

1Department of Rheumatology, Westmead Hospital, Westmead, Sydney, NSW 2145 Australia.

Background: Severe spinal pain is an unusual presentation of gout. Due to its rarity and the difficulty of obtaining joint fluid or tissue for crystal analysis, dual energy computed tomography (DECT) may be a useful imaging modality in the management of axial gout.

Case Presentation: Two patients independently presented to a major teaching hospital with severe spinal pain subsequently shown to be due to gout. Read More

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http://dx.doi.org/10.1186/s41927-020-00119-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206789PMC

F-fluorodeoxyglucose-positron emission tomography/computed tomography for the diagnosis of polymyalgia-like illnesses: a retrospective study.

BMC Rheumatol 2020 24;4:21. Epub 2020 Apr 24.

1Division of Hematology and Rheumatology, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513 Japan.

Background: Various inflammatory conditions may present with musculoskeletal symptoms similar to those of polymyalgia rheumatica (PMR). We investigated findings on F-fluorodexoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) images that may differentiate PMR from polymyalgia-like illnesses.

Methods: We analyzed data from 25 patients with new-onset polymyalgia-like illnesses who fulfilled Bird's diagnostic criteria for PMR and had undergone FDG-PET/CT scan. Read More

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http://dx.doi.org/10.1186/s41927-020-00121-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181584PMC

The impact of the illness label 'gout' on illness and treatment perceptions in Māori (Indigenous New Zealanders).

BMC Rheumatol 2020 15;4:23. Epub 2020 Apr 15.

2Department of Psychological Medicine, University of Auckland, Auckland, New Zealand.

Background: Despite contemporary advances in understanding pathogenesis and effective management of gout, beliefs about the disease continue to be focused on gout as a self-inflicted illness. The illness label itself may contribute to inaccurate perceptions of the disease and its management. In Aotearoa/New Zealand, Māori (Indigenous New Zealanders) have high prevalence of severe gout. Read More

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http://dx.doi.org/10.1186/s41927-020-00120-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158036PMC

Can the Pain Attitudes and Beliefs Scales be adapted for use in the context of osteoarthritis with general practitioners and physiotherapists?

BMC Rheumatol 2020 10;4:15. Epub 2020 Apr 10.

3Psychology Department, Auckland University of Technology, Auckland, New Zealand.

Background: Conservative, first-line treatments (exercise, education and weight-loss if appropriate) for hip and knee joint osteoarthritis are underused despite the known benefits. Clinicians' beliefs can affect the advice and education given to patients, in turn, this can influence the uptake of treatment. In New Zealand, most conservative OA management is prescribed by general practitioners (GPs; primary care physicians) and physiotherapists. Read More

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http://dx.doi.org/10.1186/s41927-020-0116-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147025PMC

Healthcare resource utilization and costs associated with inflammatory bowel disease among patients with chronic inflammatory diseases: a retrospective cohort study.

BMC Rheumatol 2020 2;4:16. Epub 2020 Apr 2.

1NYU Langone Health, 240 East 38th Street, 23rd Floor, New York, NY 10016 USA.

Background: Chronic inflammatory diseases (CIDs; ankylosing spondylitis [AS], psoriatic arthritis [PsA], psoriasis [PsO], or rheumatoid arthritis [RA]) and inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) are associated with substantial economic burden. The relative increased costs among patients with CIDs and concomitant IBD compared to those without IBD is an important consideration when deciding on the clinical management of patient symptoms. Given the increasing use of novel agents for the treatment of CIDs, including those that may increase the risk of IBD in patients with CIDs, the objective of the study was to describe the incidence of IBD and to quantify healthcare resource utilization (HRU) and costs associated with IBD among patients with CIDs. Read More

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http://dx.doi.org/10.1186/s41927-020-0115-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114816PMC

Flare or foe? - infection mimicking rheumatoid arthritis tenosynovitis: case report and literature review.

BMC Rheumatol 2020 16;4:11. Epub 2020 Mar 16.

1Department of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, D-37075 Göttingen, Germany.

Background: Rheumatoid arthritis is the most common type of inflammatory arthritis affecting about 1% of the population. With the advent of disease-modifying anti-rheumatic drugs the disease can be well controlled in many cases. Patients, however, are prone to developing infectious complications. Read More

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http://dx.doi.org/10.1186/s41927-020-0114-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074991PMC

Nutrition in RMDs: is it really food for thought? Focus on rheumatoid arthritis.

BMC Rheumatol 2020 10;4:10. Epub 2020 Mar 10.

9Research Laboratory and Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS San Martino Polyclinic Hospital, Genoa, Italy.

Background: The relationship between food and health is known since the antiquity and in the field of rheumatic and musculoskeletal diseases (RMDs), mainly rheumatoid arthritis (RA), a large number of studies has been published over the last 50 years encompassing different aspects of nutrition. This led to postulate a role of nutrients for both primary prevention of RMDs in the general population and secondary prevention of disease flares and complications in patients with an established RMD.

Main Body Of Abstract: We aimed to summarise and critically discuss current evidence on the role of different nutrients and dietary regimens in RMDs with a focus on RA. Read More

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http://dx.doi.org/10.1186/s41927-020-0113-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063796PMC

Racial disparities in pre-operative pain, function and disease activity for patients with rheumatoid arthritis undergoing Total knee or Total hip Arthroplasty: a New York based study.

BMC Rheumatol 2020 29;4:17. Epub 2020 Feb 29.

2Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021 USA.

Background: Black and Hispanic patients with osteoarthritis have more pain and worse function than Whites at the time of arthroplasty. Whether this is true for patients with rheumatoid arthritis (RA) is unknown.

Methods: This cross-sectional study used data on RA patients acquired between October 2013 and November 2018 prior to elective total knee (TKA) or hip arthroplasty (THA). Read More

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http://dx.doi.org/10.1186/s41927-020-0117-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049203PMC
February 2020

Successful long-term remission through tapering tocilizumab infusions: a single-center prospective study.

BMC Rheumatol 2020 28;4. Epub 2020 Feb 28.

1IRMB, University of Montpellier, Inserm U1183, CHU Montpellier, 371, avenue du doyen Gaston Giraud, 34295 Montpellier, France.

Background: Strategic drug therapy for rheumatoid arthritis (RA) patients with prolonged remission is not well defined. According to recent guidelines, tapering biological Disease-Modifying Anti-Rheumatic Drugs (bDMARDs) may be considered. We aimed to evaluate the effectiveness of long-term maintenance of tocilizumab (TCZ) treatment after the progressive tapering of infusions. Read More

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http://dx.doi.org/10.1186/s41927-019-0109-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047400PMC
February 2020

Unmet needs in ankylosing spondylitis patients receiving tumour necrosis factor inhibitor therapy; results from a large multinational real-world study.

BMC Rheumatol 2020 2;4:19. Epub 2020 Mar 2.

7Schlosspark-Klinik, University Medicine, Berlin, Germany.

Background: Symptoms and comorbidities of ankylosing spondylitis (AS) considerably reduce health-related quality of life (HRQoL) and ability to work. This real-world study assessed rates of tumour necrosis factor inhibitor (TNFi) use and switching, treatment failure, and associations between failing TNFi and HRQoL, work productivity and activity impairment (WPAI).

Methods: AS patients and their treating physicians completed questionnaires capturing patient demographics, clinical status, TNFi treatment history, reasons for switching TNFi, HRQoL and WPAI. Read More

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http://dx.doi.org/10.1186/s41927-020-0118-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050131PMC

Views of primary care physicians and rheumatologists regarding screening and treatment of hyperlipidemia among patients with rheumatoid arthritis.

BMC Rheumatol 2020 5;4:14. Epub 2020 Mar 5.

1Division of General Internal Medicine, Weill Cornell Medicine, 420 E 70th Street, LH-363, New York, NY 10021 USA.

Background: Despite high risk for cardiovascular disease (CVD) mortality, screening and treatment of hyperlipidemia in patients with rheumatoid arthritis (RA) is suboptimal. We asked primary care physicians (PCPs) and rheumatologists to identify barriers to screening and treatment for hyperlipidemia among patients with RA.

Methods: We recruited rheumatologists and PCPs nationally to participate in separate moderated structured group teleconference discussions using the nominal group technique. Read More

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http://dx.doi.org/10.1186/s41927-020-0112-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057468PMC

The incidence of depression and anxiety in patients with ankylosing spondylitis: a systematic review and meta-analysis.

BMC Rheumatol 2020 2;4:12. Epub 2020 Mar 2.

1Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3 Canada.

Background: As awareness for the importance of mental health continues to expand in rheumatology, it is important to understand the epidemiology of psychiatric complications in ankylosing spondylitis (AS) with the ultimate goal of future prevention and improved quality of care. This study aims to review evidence on the incidence and determinants of depression and/or anxiety among patients with AS.

Methods: We searched Medline, Embase, Cochrane Database of Systematic Reviews, CINAHL Complete, and PsycINFO for full-length observational studies that involved a sample or population of patients with AS and assessed depression and/or anxiety. Read More

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http://dx.doi.org/10.1186/s41927-019-0111-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050143PMC

The effect of glucocorticoid therapy on mortality in patients with rheumatoid arthritis and concomitant type II diabetes: a retrospective cohort study.

BMC Rheumatol 2020 19;4. Epub 2020 Feb 19.

1Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

Background: Patients with rheumatoid arthritis (RA) have increased cardiovascular (CV) and mortality risk. Patients with RA are also frequently prescribed glucocorticoids (GCs) which have been associated with increased risk of mortality. In addition, for patients who have concomitant diabetes mellitus (DM), GCs are known to worsen glycaemic control and hence may further increase CV and mortality risk. Read More

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http://dx.doi.org/10.1186/s41927-019-0105-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029556PMC
February 2020

Use of antidepressants and benzodiazepine-related hypnotics before and after initiation of TNF-α inhibitors or non-biological systemic treatment in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis.

BMC Rheumatol 2020 12;4. Epub 2020 Feb 12.

Department of Medicine Solna, Centre for Pharmacoepidemiology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.

Background: Rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are autoimmune disorders associated with an increased risk for depression, anxiety and sleeping problems. The objective of this study was to analyze use of antidepressants and benzodiazepine-related hypnotics (BRH) in Sweden before and after first time treatment with anti-TNF and non-biological systemic (NBS) treatments among patients with the above diagnoses, and to correlate such use with that of randomly selected population controls.

Methods: Patients and dispensed drugs were identified in nationwide Swedish healthcare registers. Read More

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http://dx.doi.org/10.1186/s41927-019-0106-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014636PMC
February 2020

Two cases of perforated corneal ulcers complicating rheumatoid arthritis treated successfully by biological therapy.

BMC Rheumatol 2020 7;4. Epub 2020 Feb 7.

Department of Rheumatology A, El Ayachi Hospital-Salé, CHU Ibn Sina, University Mohammed V-, Rabat, Morocco.

Background: Peripheral ulcerative keratitis (PUK) is a severe inflammatory ocular disease that can affect patients with a long history of rheumatoid arthritis (RA). The use of biotherapy has revolutionized the treatment of the RA and has provided encouraging outcomes especially in the treatment of PUK reported in few cases. In this article, we describe the case of two patients with the history of perforated corneal ulcer complicating RA treated successfully by biologic agents. Read More

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http://dx.doi.org/10.1186/s41927-019-0108-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006420PMC
February 2020

Ultrasound detects synovitis in replaced and other surgically operated joints in rheumatoid arthritis patients.

BMC Rheumatol 2020 3;4. Epub 2020 Feb 3.

1Department of Medicine, Division of Rheumatology, University of California, Los Angeles, CA USA.

Background: Joint replacements continue to occur during a rheumatoid arthritis (RA) patient's lifetime despite significant advances in available treatment options. The purpose of this study was to examine and quantify synovitis in surgically operated joints by ultrasound (US) in RA patients starting a new therapeutic agent.

Methods: RA subjects were enrolled in either tocilizumab or tofacitinib open-label, investigator-initiated trials and were assessed by ultrasound. Read More

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http://dx.doi.org/10.1186/s41927-019-0107-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996180PMC
February 2020

S100A4 is elevated in axial spondyloarthritis: a potential link to disease severity.

BMC Rheumatol 2020 31;4:13. Epub 2020 Jan 31.

1Institute of Rheumatology, Prague, Czech Republic.

Background: S100A4 is a member of calcium binding S100 protein family well known for its role in cancer progression and metastasis. Nevertheless, S100A4 also serves as a negative regulator of bone formation. Dickkopf-1 (DKK-1), marker of bone remodelling, is also implicated in the process of syndesmophyte formation in ankylosing spondylitis. Read More

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http://dx.doi.org/10.1186/s41927-019-0110-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993388PMC
January 2020

A case of localized tracheobronchial relapsing polychondritis with positive matrilin-1 staining.

BMC Rheumatol 2020 29;4. Epub 2020 Jan 29.

1Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574 Japan.

Background: Relapsing polychondritis (RPC) is a rare progressive autoimmune disease characterized by inflammation in the cartilage of multiple organs. Tracheobronchial involvement appears in nearly half of RPC patients during the course of their disease and represents the main cause of death. Localized tracheobronchial RPC is much rarer, and the pathogenesis remains unclear. Read More

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http://dx.doi.org/10.1186/s41927-019-0103-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988282PMC
January 2020

Dual energy CT findings in gout with rapid kilovoltage-switching source with gemstone scintillator detector.

BMC Rheumatol 2020 17;4. Epub 2020 Jan 17.

2Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Gothenburg, Sweden.

Background: A definite diagnosis of gout requires demonstration of monosodium urate crystals in synovial fluid or in tophi, which in clinical practice today seldom is done. Dual energy CT (DECT) has repeatedly been shown to be able to detect monosodium urate crystals in tissues, hence being an alternative method to synovial fluid microscopy. The vast majority of these studies were performed with CT scanners with two X-ray tubes. Read More

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http://dx.doi.org/10.1186/s41927-019-0104-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966802PMC
January 2020

Patients' perspectives of outcomes after total knee and total hip arthroplasty: a nominal group study.

BMC Rheumatol 2020 13;4. Epub 2020 Jan 13.

4Department of Medicine, University of Alabama, 1802 6th Avenue, Birmingham, AL 35233 USA.

Background: While total joint replacements (TJR) are frequently performed, there is little qualitative research to define the outcomes most important to patients.

Methods: Patients who had received total hip (THR) or total knee replacements (TKR) participated in 8 nominal groups to answer the question "What result/results matter the most to a patient undergoing/having a knee or hip replacement?" Total 270 votes were allocated.

Results: Eight nominal groups were performed with 45 patients, 6 groups with mean age (71. Read More

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http://dx.doi.org/10.1186/s41927-019-0101-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956500PMC
January 2020

Patient perspectives on the pathway to psoriatic arthritis diagnosis: results from a web-based survey of patients in the United States.

BMC Rheumatol 2020 10;4. Epub 2020 Jan 10.

5Novartis Pharmaceuticals Corporation, East Hanover, NJ USA.

Background: There are limited real-world data on the diagnostic experiences of patients with psoriatic arthritis (PsA), including medical care sought and potential barriers to diagnosis. We aim to describe patient experiences related to receiving a PsA diagnosis.

Methods: Ours was a mixed-method, 2-phase study. Read More

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http://dx.doi.org/10.1186/s41927-019-0102-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953285PMC
January 2020

Serum levels of reactive oxygen metabolites at 12 weeks during tocilizumab therapy are predictive of 52 weeks-disease activity score-remission in patients with rheumatoid arthritis.

BMC Rheumatol 2019 16;3:48. Epub 2019 Dec 16.

1Department of Orthopaedics, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba, 285-8741 Japan.

Background: To verify whether serum levels of reactive oxygen metabolites (ROM) are predictive of future clinical remission in patients with rheumatoid arthritis (RA) receiving tocilizumab (TCZ) therapy.

Methods: A total of 46 patients with RA receiving TCZ therapy were enrolled in this study. Patients were divided into remission and non-remission groups based on disease activity score 28 (DAS28)-erythrocyte sedimentation rate (ESR) or clinical disease activity index (CDAI) at 52 weeks. Read More

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http://dx.doi.org/10.1186/s41927-019-0096-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912997PMC
December 2019

Factors that influence rheumatologists' anti-tumor necrosis factor alpha prescribing decisions: a qualitative study.

BMC Rheumatol 2019 19;3:47. Epub 2019 Dec 19.

2NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Background: Treatment decisions for any disease are usually informed by reference to published clinical guidelines or recommendations. These recommendations can be developed to improve the relative cost-effectiveness of health care and to reduce regional variation in clinical practice. Anti-tumor necrosis factor alpha (anti-TNF) treatments are prescribed for people with rheumatoid arthritis according to specific recommendations by the National Institute for Health and Care Excellence in England. Read More

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http://dx.doi.org/10.1186/s41927-019-0097-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921483PMC
December 2019

Use of a "critical difference" statistical criterion improves the predictive utility of the Health Assessment Questionnaire-Disability Index score in patients with rheumatoid arthritis.

BMC Rheumatol 2019 10;3:51. Epub 2019 Dec 10.

1Division of Rheumatology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Background: The Health Assessment Questionnaire-Disability Index (HAQ-DI) is used to assess functional status in rheumatoid arthritis (RA), but the change required for meaningful improvements remains unclear. A minimum clinically important difference (MCID) of 0.22 is frequently used in RA trials. Read More

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http://dx.doi.org/10.1186/s41927-019-0095-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902502PMC
December 2019

Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae.

BMC Rheumatol 2019 18;3:49. Epub 2019 Nov 18.

1Pain Centre Versus Arthritis, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, NG5 1PB UK.

Background: RA flares are common and disabling. They are described in terms of worsening inflammation but pain and inflammation are often discordant. To inform treatment decisions, we investigated whether inflammatory and pain flares are discrete entities. Read More

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http://dx.doi.org/10.1186/s41927-019-0100-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859633PMC
November 2019

Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis.

BMC Rheumatol 2019 2;3:46. Epub 2019 Dec 2.

1Department of Immunology and Rheumatology, Stanford University, Stanford, CA USA.

Background: The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Tissue repair responses include transforming growth factor beta (TGFβ)-induced myofibroblast production of extracellular matrix. Fibronectins are an essential part of the extracellular matrix, and injection of fibronectin fragments into rabbit joints is a previously established animal model of OA. Read More

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http://dx.doi.org/10.1186/s41927-019-0093-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886182PMC
December 2019

Serious infections in patients with self-reported psoriatic arthritis from the Psoriasis Longitudinal Assessment and Registry (PSOLAR) treated with biologics.

BMC Rheumatol 2019 28;3:52. Epub 2019 Nov 28.

8New York Medical College, Metropolitan Hospital, New York, NY USA.

Background: Patients with psoriatic arthritis (PsA) have increased risk of adverse events, including serious infections (SI), compared with psoriasis patients.

Methods: Patients eligible for, or receiving conventional systemic and biologic agents for psoriasis were followed prospectively using PSOLAR. Cohorts included: ustekinumab, tumor necrosis factor (TNF) inhibitors; infliximab; etanercept; adalimumab; non-biologic/methotrexate (MTX) (reference group); and non-biologic/non-MTX. Read More

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http://dx.doi.org/10.1186/s41927-019-0094-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882230PMC
November 2019

Expert consensus on relevant risk predictors for the occurrence of osteoporotic fractures in specific clinical subgroups - Delphi survey.

BMC Rheumatol 2019 12;3:50. Epub 2019 Nov 12.

Medignition Inc. Medical Research Consultants, Verena Conzett-Strasse 9, 8004 Zurich, Switzerland.

Background: There is an ongoing discussion about incorporating additional risk factors to established WHO fracture risk assessment tool (FRAX) to improve the prediction accuracy in clinical subgroups. We aimed to reach an expert consensus on possible additional predictive parameters for specific clinical subgroups.

Methods: Two-round modified Delphi survey: We generated a shortlist of experts from the authors' lists of the pertinent literature and complemented the list with experts known to the authors. Read More

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http://dx.doi.org/10.1186/s41927-019-0099-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849295PMC
November 2019

Takayasu arteritis with pyoderma gangrenosum: case reports and literature review.

BMC Rheumatol 2019 5;3:45. Epub 2019 Nov 5.

2Department of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Shuaifuyuan, Wangfujing St., Beijing, 100730 China.

Background: Takayasu arteritis is a rare, chronic inflammatory arteriopathy affecting mainly the aorta and its branches. Many skin manifestations have been reported in association with this disease. Pyoderma gangrenosum is a skin complication that is a neutrophilic dermatosis characterized by destructive, necrotizing and noninfective skin infiltration. Read More

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http://dx.doi.org/10.1186/s41927-019-0098-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829831PMC
November 2019
2 Reads

Fibromyalgia in the workplace: risk factors for sick leave are related to professional context rather than fibromyalgia characteristics- a French national survey of 955 patients.

BMC Rheumatol 2019 26;3:44. Epub 2019 Oct 26.

2Pain department, Cochin Hospital, Paris Descartes University, INSERM U987, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.

Background: Work and workplace factors are important in fibromyalgia management. We investigated factors associated with sick leave in professionally active women living with fibromyalgia.

Methods: A questionnaire for fibromyalgia patients in employment was developed by pain and occupational physicians and patients' organizations. Read More

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http://dx.doi.org/10.1186/s41927-019-0089-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815377PMC
October 2019

The multifaceted impact of anxiety and depression on patients with rheumatoid arthritis.

BMC Rheumatol 2019 28;3:43. Epub 2019 Oct 28.

Janssen Global Services, Horsham, PA USA.

Background: The prevalence of mood disturbances such as anxiety and depression is greater in rheumatoid arthritis (RA) patients than in the general population. Given this association, the primary aim of this study was to assess the incremental impact of anxiety or depression on patients with RA from the United States of America (USA) and Europe, independent of the impact of the underlying RA disease.

Methods: Rheumatologists ( = 408) from the USA and 5 European countries completed patient record forms for a predetermined number of RA patients who consulted consecutively during the study period; these patients completed patient-reported questionnaires. Read More

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http://dx.doi.org/10.1186/s41927-019-0092-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816159PMC
October 2019

A systematic review of guidelines for managing rheumatoid arthritis.

BMC Rheumatol 2019 22;3:42. Epub 2019 Oct 22.

Academic Rheumatology, Department of Inflammation Biology, School of Immunology And Microbial Sciences, King's College London, Weston Education Centre, Denmark Hill, London, SE5 9RT UK.

Background: We systematically reviewed current guidelines for managing rheumatoid arthritis (RA) to evaluate their range and nature, assess variations in their recommendations and highlight divergence in their perspectives.

Methods: We searched Medline and Embase databases using the terms 'clinical practice guidelines' and 'rheumatoid arthritis' from January 2000 to January 2017 together with publications of national and international bodies. We included guidelines providing recommendations on general RA management spanning a range of treatments and published in English. Read More

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http://dx.doi.org/10.1186/s41927-019-0090-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805606PMC
October 2019

A review of accelerometer-derived physical activity in the idiopathic inflammatory myopathies.

BMC Rheumatol 2019 21;3:41. Epub 2019 Oct 21.

1Centre for Epidemiology Versus Arthritis, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT UK.

Background: The idiopathic inflammatory myopathies (IIMs) are a group of rare conditions characterised by muscle inflammation (myositis). Accurate disease activity assessment is vital in both clinical and research settings, however, current available methods lack ability to quantify associated variation of physical activity, an important consequence of myositis.This study aims to review studies that have collected accelerometer-derived physical activity data in IIM populations, and to investigate if these studies identified associations between physical and myositis disease activity. Read More

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http://dx.doi.org/10.1186/s41927-019-0088-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805320PMC
October 2019
2 Reads

Development of ReproKnow, a reproductive knowledge assessment for women with rheumatic diseases.

BMC Rheumatol 2019 21;3:40. Epub 2019 Oct 21.

4Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA USA.

Background: The objective of this study was to develop an assessment tool, ReproKnow, to evaluate the reproductive health knowledge of women with a wide range of rheumatic diseases.

Methods: The 10-item multiple-choice questionnaire was developed with feedback from a panel of content experts and female patients with rheumatic diseases. Construct validity using known-groups analysis was evaluated through comparison of median total ReproKnow scores between rheumatology fellows and nurses. Read More

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http://dx.doi.org/10.1186/s41927-019-0091-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805554PMC
October 2019

Trends in diagnostic prevalence and treatment patterns of male and female ankylosing spondylitis patients in the United States, 2006-2016.

BMC Rheumatol 2019 23;3:39. Epub 2019 Sep 23.

2Eli Lilly and Company, Indianapolis, Indiana USA.

Background: There has been much variation between epidemiological studies that report the prevalence of ankylosing spondylitis (AS). This study aimed to analyze the diagnostic prevalence rates and treatment patterns of male and female AS patients in the United States adult insured population from 2006 to 2016.

Methods: Trends in AS prevalence were calculated for the 11-year period covering January 1, 2006 to December 31, 2016. Read More

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http://dx.doi.org/10.1186/s41927-019-0086-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755695PMC
September 2019
2 Reads

Group B streptococcus is the most common pathogen for septic arthritis with unique clinical characteristics: data from 12 years retrospective cohort study.

BMC Rheumatol 2019 16;3:38. Epub 2019 Sep 16.

Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine, 315 Ratchawithi road, Bangkok, Ratchathewi District 10400 Thailand.

Background: Group B Streptococcus (GBS) emerged as the frequent pathogen for septic arthritis. There was no study comparing risks, clinical presentations and outcomes between GBS septic arthritis and other bacterial septic arthritis.The aim of this study is to evaluate the differences in risks, clinical presentations, and outcomes of GBS septic arthritis and other bacterial septic arthritis, and identify independent risks and clinical presentations suggesting GBS septic arthritis. Read More

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http://dx.doi.org/10.1186/s41927-019-0084-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745788PMC
September 2019
1 Read

Prevalence and associated factors of subclinical atherosclerosis in rheumatoid arthritis at the university hospital of Kinshasa.

BMC Rheumatol 2019 9;3:37. Epub 2019 Sep 9.

Rheumatology Unit, Department of internal medicine, University Hospital of Kinshasa, Kinshasa, Democratic Republic of Congo.

Background: Rheumatoid arthritis (RA) is associated with a 5 to 10 years reduction in life expectancy due to premature atherosclerosis. This reduction is the consequence of traditional cardiovascular risk factors (TCRF) as well as systemic inflammation. The aim of the present study was to describe the prevalence and factors associated with subclinical atherosclerosis in RA at the University Hospital of Kinshasa (UHK). Read More

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http://dx.doi.org/10.1186/s41927-019-0085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732832PMC
September 2019
1 Read

Which patient reported outcome domains are important to the rheumatologists while assessing patients with rheumatoid arthritis?

BMC Rheumatol 2019 5;3:36. Epub 2019 Sep 5.

3Division of General Internal Medicine, Weill Cornell Medicine, 420 E 70th St., LH-363, New York, NY 10021 USA.

Background: Patient-reported outcomes (PROs) aid in rheumatoid arthritis (RA) management, but it is not well understood which measures would be most relevant to the rheumatologists for making treatment decisions.

Methods: We recruited rheumatologists nationally to participate in moderated structured group teleconference discussions using the nominal group technique. Participants in each group generated lists of the elements from patient's history and signs that they use to make treatment recommendations for RA. Read More

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http://dx.doi.org/10.1186/s41927-019-0087-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727422PMC
September 2019
1 Read

Adverse infusion reactions to rituximab in systemic lupus erythematosus: a retrospective analysis.

BMC Rheumatol 2019 29;3:32. Epub 2019 Aug 29.

5Division of Rheumatology, Department of Medicine, University College London Hospitals & Centre for Rheumatology, London, UK.

Background: To undertake a retrospective review of patients with SLE who had received Rituximab in order to determine the rates and associated patient characteristics of clinically significant adverse infusion reactions.

Methods: A descriptive analysis was undertaken of each infusion reaction, which was then assessed using the clinical information available to hypothesise on the possible underlying mechanism(s).

Results: Records of 136 SLE patients previously treated with 481 individual infusions of Rituximab were reviewed. Read More

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http://dx.doi.org/10.1186/s41927-019-0082-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714312PMC
August 2019
1 Read

Erratum: Publisher Correction to: BMC Rheumatology, volume 3.

Authors:

BMC Rheumatol 2019;3:35. Epub 2019 Aug 20.

[This corrects the article DOI: 10.1186/s41927-019-0072-9.][This corrects the article DOI: 10. Read More

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http://dx.doi.org/10.1186/s41927-019-0083-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701100PMC