56 results match your criteria BMC rheumatology[Journal]


Intensive management for moderate rheumatoid arthritis: a qualitative study of patients' and practitioners' views.

BMC Rheumatol 2019 28;3:12. Epub 2019 Mar 28.

1Department of Inflammation Biology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, 10 Cutcombe Road, Denmark Hill, London, SE5 9RJ UK.

Background: The TITRATE trial seeks to test whether intensive management is valuable in achieving disease remission in moderately active rheumatoid arthritis. Intensive management is a complex intervention consisting of: 1) 12 x monthly appointments, 2) tailored 'treatment support' based on motivational interviewing techniques, 3) optimised medication (including the opportunity for biologics), 4) provision of a Patient Handbook, and 5) shared treatment planning. This study aims to understand: a) patients' and practitioners' views on the feasibility and acceptability of intensive management, and b) patients' and practitioners' experience of receiving/providing intensive management. Read More

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http://dx.doi.org/10.1186/s41927-019-0057-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437952PMC

Incident gout and chronic Kidney Disease: healthcare utilization and survival.

BMC Rheumatol 2019 19;3:11. Epub 2019 Mar 19.

Clalit Research Institute, Zamenhoff 42, Floor - 1, 6435331 Tel Aviv, Israel.

Background: Uncontrolled gout can cause significant joint and organ damage and has been associated with impairments in quality of life and high economic cost. Gout has also been associated with other comorbid diseases, such as chronic kidney disease. The current study explored if healthcare resource utilization (HRU) and survival differs between patients with incident gout in the presence or absence of chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1186/s41927-019-0060-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425669PMC
March 2019
2 Reads

Relapse rates after elective discontinuation of anti-TNF therapy in rheumatoid arthritis: a meta-analysis and review of literature.

BMC Rheumatol 2019 8;3:10. Epub 2019 Mar 8.

6Department of Rheumatology and Rehabilitation, Tanta University Faculty of Medicine, Elgesh Street, Tanta, Gharbeia Egypt.

Background: Inhibitors of tumor necrosis factor alpha (TNF-α) are current mainstay of therapies for rheumatoid arthritis (RA). The decision when to withdraw TNF-α inhibitors after achieving remission and the incidence of relapse rates with elective discontinuation are both important questions that demand intense survey in these patients. In this meta-analysis we aimed to estimate the magnitude of relapse rate after elective TNF-α inhibitor discontinuation in RA patients with remission. Read More

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http://dx.doi.org/10.1186/s41927-019-0058-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408847PMC
March 2019
1 Read

Eosinophils in anti-neutrophil cytoplasmic antibody associated vasculitis.

BMC Rheumatol 2019 8;3. Epub 2019 Mar 8.

2Department of Hematology, Skane University Hospital and Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.

Background: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregulatory properties. Tissue activated eosinophils secrete cyto- and chemokines and form extracellular traps (EETs), they release free granules and produce reactive oxygen species. Read More

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http://dx.doi.org/10.1186/s41927-019-0059-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408823PMC
March 2019
1 Read

Gout and sexual function: patient perspective of how gout affects personal relationships and intimacy.

BMC Rheumatol 2019 28;3. Epub 2019 Feb 28.

1Medicine Service, Birmingham VA Medical Center, 700 19th St S, Birmingham, AL 35233 USA.

Background: In absence of previous studies, we assessed how gout impacts relationship and intimacy with spouse/significant other.

Methods: We enrolled a convenience sample of consecutive patients with doctor-diagnosed gout from a community-based outpatient clinic. Nominal groups were conducted until saturation was achieved. Read More

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http://dx.doi.org/10.1186/s41927-019-0056-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396531PMC
February 2019
2 Reads

Severe skin disease in lupus associated with hemophagocytic lymphohistiocytosis: case reports and review of the literature.

BMC Rheumatol 2019 8;3. Epub 2019 Feb 8.

3Division of Rheumatology, Department of Medicine, University of Calgary, Calgary, Alberta Canada.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe clinical entity associated with high mortality in the adult population. HLH has been associated with infections, malignancy and autoimmune conditions such as Systemic Lupus Erythematosus (SLE), however this is often in the context of a disease flare. Currently, there are limited reports of inaugural SLE manifesting as HLH with a lack of consensus on treatment and management of these patients. Read More

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http://dx.doi.org/10.1186/s41927-019-0055-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390523PMC
February 2019
1 Read

Real world long-term impact of intensive treatment on disease activity, disability and health-related quality of life in rheumatoid arthritis.

BMC Rheumatol 2019 25;3. Epub 2019 Feb 25.

5Department of Rheumatology, Guy's and St Thomas' NHS Trust, 4th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, UK.

Background: The emphasis on treating rheumatoid arthritis (RA) intensively reduces disease activity but its impact in routine care is uncertain. We evaluated temporal changes in disease activities and outcomes in a 10-year prospective observational cohort study of patients in routine care at one unit.

Methods: The Guy's and St Thomas' RA cohort was established in 2005. Read More

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http://dx.doi.org/10.1186/s41927-019-0054-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390620PMC
February 2019
1 Read

Living life precariously with rheumatoid arthritis - a mega-ethnography of nine qualitative evidence syntheses.

BMC Rheumatol 2019 6;3. Epub 2019 Feb 6.

1Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Background: Rheumatoid arthritis is an autoimmune disease that causes joint inflammation. It affects around 400,000 people in the UK and 1 million adults in the USA. Given the appropriate treatment, many can have relatively few symptoms. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0049-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390589PMC
February 2019
6 Reads

Comparative study of Interleukin-18 (IL-18) serum levels in adult onset Still's disease (AOSD) and systemic onset juvenile idiopathic arthritis (sJIA) and its use as a biomarker for diagnosis and evaluation of disease activity.

BMC Rheumatol 2019 28;3. Epub 2019 Feb 28.

1Clinic of Rheumatology, University of Magdeburg, Sophie-von-Boetticher-Strasse 1, 39245 Vogelsang-Gommern, Germany.

Background: Signs and symptoms establish the diagnosis of adult onset Still's disease (AOSD) as well as of systemic onset juvenile idiopathic arthritis (sJIA). The published data regarding the importance of IL-18 as a marker for diagnosis and disease activity so far are conflicting. The aim of this study was to clarify the role of IL-18 as a diagnostic and disease activity marker in AOSD and sJIA. Read More

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http://dx.doi.org/10.1186/s41927-019-0053-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394042PMC
February 2019
2 Reads

Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis.

BMC Rheumatol 2019 31;3. Epub 2019 Jan 31.

1Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev Hovedgade 205-207, 2730 Herlev, Denmark.

Background: Biomarkers of rheumatoid arthritis (RA) disease activity typically measure inflammation or autoimmunity (e.g. CRP, RF). Read More

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http://dx.doi.org/10.1186/s41927-019-0052-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390574PMC
January 2019
1 Read

Effectiveness and cost-effectiveness of the modified Pilates method versus aerobic exercise in the treatment of patients with fibromyalgia: protocol for a randomized controlled trial.

BMC Rheumatol 2019 18;3. Epub 2019 Jan 18.

1Master's and Doctoral Program in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno 475, São Paulo SP, CEP: 03071-000 Brazil.

Background: Fibromyalgia is characterized by chronic generalized pain, fatigue, sleep disorders and other symptoms. Physical exercise is recommended as the first choice of non-pharmacological therapy. Thus, the aim of this study is to evaluate the effectiveness and cost-effectiveness of modified Pilates exercises compared to aerobic exercises in the treatment of patients with fibromyalgia. Read More

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http://dx.doi.org/10.1186/s41927-018-0051-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390629PMC
January 2019
3 Reads

Malignancy risk in Australian rheumatoid arthritis patients treated with anti-tumour necrosis factor therapy: an update from the Australian Rheumatology Association Database (ARAD) prospective cohort study.

BMC Rheumatol 2019 8;3. Epub 2019 Jan 8.

1Monash Department of Clinical Epidemiology, Cabrini Institute, Melbourne, Australia.

Background: Tumour necrosis factor inhibitor (TNFi) therapy has been available for rheumatoid arthritis (RA) patients for several decades but data on the long-term risk of malignancy associated with its use is limited. Our aims were to assess malignancy risk in a cohort of Australian RA patients relative to the Australian population and to compare cancer risk for patients exposed to TNFi therapy versus a biologic-naïve group.

Methods: Demographic data for RA participants enrolled in the Australian Rheumatology Association Database (ARAD) before 31 Dec 2012 were matched to national cancer records in May 2016 (linkage complete to 2012). Read More

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http://dx.doi.org/10.1186/s41927-018-0050-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390524PMC
January 2019
4 Reads

Association of Catechol--methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients.

BMC Rheumatol 2018 12;2:38. Epub 2018 Dec 12.

Mycroft Bioanalytics, Inc., 299 South Main Street, Suite 2300, Salt Lake City, UT 84111-2278 USA.

Background: Fibromyalgia (FM) is a complex, centralized pain condition that is often difficult to diagnose and treat. FM is considered to have a genetic background due to its familial aggregation and due to findings from multiple candidate-gene studies implicating catecholaminergic and serotonergic neurotransmitter systems in chronic pain. However, a multi-factorial analysis of both genetic and environmental risk factors is lacking. Read More

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http://dx.doi.org/10.1186/s41927-018-0045-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390547PMC
December 2018
1 Read

Positive melioidosis serology in a patient with adult onset Still's disease: a case report of a diagnostic dilemma.

BMC Rheumatol 2018 10;2:37. Epub 2018 Dec 10.

4Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Autoimmune disorders are known to produce false positives in serological tests for infections. Aetiological association between infections and autoimmunity, increased susceptibility to infectious and autoimmune disorders with immune dysregulation and non-specific polyclonal expansion of B cells with autoimmunity may cause confusion in diagnosis and patient management. We report a patient with Adult Onset Still's Disease (AOSD) presenting with rising melioidosis antibody titres that caused diagnostic confusion. Read More

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http://dx.doi.org/10.1186/s41927-018-0044-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390555PMC
December 2018
1 Read

Trends in incidence, mortality, and causes of death associated with systemic sclerosis in Denmark between 1995 and 2015: a nationwide cohort study.

BMC Rheumatol 2018 7;2:36. Epub 2018 Dec 7.

5Department of Cardiology, Herlev and Gentofte Hospital, Gentofte, Kildegårdsvej 28, 2900 Hellerup, Denmark.

Background: To investigate the incidence and the mortality-rates of systemic sclerosis (SSc), its primary causes of death, and the temporal trends in events in Denmark during the last decades.

Methods: Using the Danish National Patient Registry, we identified all persons aged ≥18 years with a first-time diagnosis of SSc (ICD-10 code M34, excluding M34.2) between 1995 and 2015. Read More

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http://dx.doi.org/10.1186/s41927-018-0043-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390621PMC
December 2018

A proteomic analysis of serum-derived exosomes in rheumatoid arthritis.

BMC Rheumatol 2018 27;2:35. Epub 2018 Nov 27.

1Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, 2-16-1, Sugao, Miyamae, Kawasaki, Kanagawa 216-8511 Japan.

Background: To understand the roles of serum exosomes in rheumatoid arthritis (RA), we comprehensively investigated the protein profiles of serum exosomes in patients with RA.

Methods: Exosomes were isolated from serum samples obtained from 33 patients (12 with active RA [aRA], 11 with inactive RA [iRA], 10 with osteoarthritis [OA]) and 10 healthy donors (HLs). Proteins extracted from the exosomes were separated by two-dimensional differential gel electrophoresis (2D-DIGE) and identified by mass spectrometry. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0041-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390805PMC
November 2018
8 Reads

Atypical presentation of pneumonia in a patient with rheumatoid arthritis treated with tofacitinib: a case presentation.

BMC Rheumatol 2018 3;2:34. Epub 2018 Nov 3.

3Department of Rheumatology, Immunology and Rehabilitation, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Background: We report the case of a patient with rheumatoid arthritis (RA) treated with tofacitinib who developed severe pneumonia (PJP) with an atypical clinical presentation.

Case Presentation: A 78-year old male patient with RA treated with tofacitinib, methotrexate (MTX) and low dose corticosteroids was admitted to the hospital with arthralgia and nausea. Laboratory findings revealed hypercalcemia with normal levels of parathyroid hormone (PTH) and elevated 1,25-(OH) vitamin D levels. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0042-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390573PMC
November 2018
3 Reads

The antifibrotic drug pirfenidone inhibits spondyloarthritis fibroblast-like synoviocytes and osteoblasts in vitro.

BMC Rheumatol 2018 19;2:33. Epub 2018 Nov 19.

1Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Background: The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized as both inflammatory and fibrotic. The current treatment dampens inflammation while new bone formation can progress. Read More

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http://dx.doi.org/10.1186/s41927-018-0040-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390625PMC
November 2018

The extra-articular impacts of rheumatoid arthritis: moving towards holistic care.

BMC Rheumatol 2018 30;2:32. Epub 2018 Oct 30.

1Research Institute for Primary Care & Health Sciences, Primary Care Sciences, Keele University, Newcastle-under-Lyme, Staffordshire UK.

Although treat-to-target has revolutionised the outcomes of patients with rheumatoid arthritis (RA) there is emerging evidence that attaining the target of remission is insufficient to normalise patients' quality of life, and ameliorate the extra-articular impacts of RA. RA has a broad range of effects on patient's lives, with four key "extra-articular" impacts being pain, depression and anxiety, fatigue and rheumatoid cachexia. All of these are seen frequently; for example, studies have reported that 1 in 4 patients with RA have high-levels of fatigue. Read More

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http://dx.doi.org/10.1186/s41927-018-0039-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390577PMC
October 2018
4 Reads

Perceptions of first-degree relatives of patients with rheumatoid arthritis about lifestyle modifications and pharmacological interventions to reduce the risk of rheumatoid arthritis development: a qualitative interview study.

BMC Rheumatol 2018 6;2:31. Epub 2018 Nov 6.

1Institute for Inflammation and Aging, Rheumatology Research Group, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT UK.

Background: There is increasing interest in the identification of people at risk of rheumatoid arthritis (RA) to monitor the emergence of early symptoms (and thus allow early therapy), offer lifestyle advice to reduce the impact of environmental risk factors and potentially offer preventive pharmacological treatment for those at high risk. Close biological relatives of people with RA are at an increased risk of developing RA and are therefore potential candidates for research studies, screening initiatives and preventive interventions. To ensure the success of approaches of this kind, a greater understanding of the perceptions of this group relating to preventive measures is needed. Read More

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http://dx.doi.org/10.1186/s41927-018-0038-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390593PMC
November 2018
1 Read

General practitioners' views on managing knee osteoarthritis: a thematic analysis of factors influencing clinical practice guideline implementation in primary care.

BMC Rheumatol 2018 26;2:30. Epub 2018 Oct 26.

1Centre for Health, Exercise and Sports Medicine, The University of Melbourne, Melbourne, Australia.

Background: Osteoarthritis (OA) is diagnosed and managed primarily by general practitioners (GPs). OA guidelines recommend using clinical criteria, without x-ray, for diagnosis, and advising strengthening exercise, aerobic activity and, if appropriate, weight loss as first-line treatments. These recommendations are often not implemented by GPs. Read More

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http://dx.doi.org/10.1186/s41927-018-0037-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390779PMC
October 2018
2 Reads

Demography, baseline disease characteristics, and treatment history of psoriasis patients with self-reported psoriatic arthritis enrolled in the PSOLAR registry.

BMC Rheumatol 2018 29;2:29. Epub 2018 Sep 29.

8Division of Rheumatology, New York University School of Medicine and Hospital for Joint Diseases, 301 East 17th Street, Room 1608, New York, NY 10003 USA.

Background: To evaluate demographics, family history, and previous medication use at enrollment in a subset of psoriasis patients with self-reported psoriatic arthritis (PsA) enrolled in Psoriasis Longitudinal Assessment and Registry (PSOLAR).

Methods: PSOLAR is an international, prospective, longitudinal, disease-based registry that collects data in patients receiving, or are eligible to receive, systemic or biologic treatments for psoriasis. Baseline demographic, disease characteristics, medical history, and prior medication use at enrollment were evaluated in PSOLAR psoriasis patients self-reporting PsA ( = 4315); a subset of which had their diagnosis of PsA established by a healthcare provider (HCP;  = 1719); patients with psoriasis only ( = 7775); and the overall PSOLAR population ( = 12,090). Read More

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http://dx.doi.org/10.1186/s41927-018-0034-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390609PMC
September 2018
2 Reads

The role of vitamin D testing and replacement in fibromyalgia: a systematic literature review.

BMC Rheumatol 2018 5;2:28. Epub 2018 Oct 5.

3Department of Rheumatology, Worthing Hospital, Worthing, BN11 2DH UK.

Background: Fibromyalgia is a debilitating condition, characterized by extensive muscular pain and fatigue. Vitamin D is essential for overall health, with ubiquitous involvement in various inflammatory and pain pathways. Little is known about its role in fibromyalgia. Read More

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http://dx.doi.org/10.1186/s41927-018-0035-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390590PMC
October 2018
1 Read

Resveratrol displays anti-inflammatory properties in an ex vivo model of immune mediated inflammatory arthritis.

BMC Rheumatol 2018 10;2:27. Epub 2018 Oct 10.

1Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Background: Resveratrol is a natural polyphenol found in berries, roots and wine that is well known to have anti-inflammatory and anti-oxidative properties. The anti-inflammatory effect has been reported for both immune cells and connective tissues, but only few studies have investigated effects on immune mediated inflammatory arthritis. None of which have studied this effect when combining resveratrol with methotrexate or adalimumab, two major drugs in the treatment of immune mediated inflammatory arthritis. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0036-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390607PMC
October 2018
3 Reads

Vitamin D in individuals before onset of rheumatoid arthritis - relation to vitamin D binding protein and its associated genetic variants.

BMC Rheumatol 2018 12;2:26. Epub 2018 Sep 12.

1Department of Public Health and Clinical Medicine/ Rheumatology, Umeå University, SE-90185 Umeå, Sweden.

Background: Vitamin D has been implicated as being involved in the aetio-pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA). Previous studies present contradictory results. Vitamin D binding protein (DBP), the major transport protein, is also involved in various inflammatory processes. Read More

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http://dx.doi.org/10.1186/s41927-018-0033-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390591PMC
September 2018
1 Read

Cardiovascular risk management in rheumatoid and psoriatic arthritis: online survey results from a national cohort study.

BMC Rheumatol 2018 6;2:25. Epub 2018 Sep 6.

1Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Sydney, NSW Australia.

Background: Chronic inflammatory arthritis is associated with increased cardiovascular (CV) morbidity and mortality. Pharmacological management and healthy lifestyle modification is recommended to manage these risks, but it is not known how often these are utilised and whether there is any difference in their use between patients with different types of arthritis. The aim of this study was to determine and compare the proportion of participants with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) receiving pharmacological or lifestyle management strategies for CV risk factors. Read More

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http://dx.doi.org/10.1186/s41927-018-0032-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390588PMC
September 2018
1 Read

Achieving minimal disease activity in psoriatic arthritis predicts meaningful improvements in patients' health-related quality of life and productivity.

BMC Rheumatol 2018 13;2:24. Epub 2018 Aug 13.

6University of Leeds School of Medicine, Leeds, UK.

Background: Although psoriatic arthritis is complex and involves multiple domains, recent advances in treatments have made remission or near-remission of most symptoms a potentially achievable goal for many patients. We sought to evaluate whether achieving minimal disease activity (MDA) criteria represented meaningful improvement from the patient perspective.

Methods: Data were combined from two randomized, multinational, 24 week clinical studies of ixekizumab, a high-affinity monoclonal antibody selectively targeting interleukin-17A, in biological drug-naïve or experienced adults. Read More

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http://dx.doi.org/10.1186/s41927-018-0030-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390571PMC
August 2018
1 Read

In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494).

BMC Rheumatol 2018 28;2:23. Epub 2018 Aug 28.

1Immunology Discovery Research, AbbVie Bioresearch Center, 100 Research Dr, Worcester, MA 01605 USA.

Background: Anti-cytokine therapies such as adalimumab, tocilizumab, and the small molecule JAK inhibitor tofacitinib have proven that cytokines and their subsequent downstream signaling processes are important in the pathogenesis of rheumatoid arthritis. Tofacitinib, a pan-JAK inhibitor, is the first approved JAK inhibitor for the treatment of RA and has been shown to be effective in managing disease. However, in phase 2 dose-ranging studies tofacitinib was associated with dose-limiting tolerability and safety issues such as anemia. Read More

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http://dx.doi.org/10.1186/s41927-018-0031-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390583PMC

Identifying the unmet information and support needs of women with autoimmune rheumatic diseases during pregnancy planning, pregnancy and early parenting: mixed-methods study.

BMC Rheumatol 2018 27;2:21. Epub 2018 Jul 27.

1Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK.

Background: Autoimmune rheumatic diseases (ARDs) such as inflammatory arthritis and Lupus, and many of the treatments for these diseases, can have a detrimental impact on fertility and pregnancy outcomes. Disease activity and organ damage as a result of ARDs can affect maternal and foetal outcomes. The safety and acceptability of hormonal contraceptives can also be affected. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0029-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390539PMC
July 2018
2 Reads

Evolution into Takayasu arteritis in a patient presenting with acute pulmonary oedema due to severe aortic regurgitation; a case report.

BMC Rheumatol 2018 12;2:20. Epub 2018 Jul 12.

1Professorial Unit in Medicine, National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Takayasu arteritis is a rare large vessel vasculitis which predominantly affects young Asian females. Aortic regurgitation and heart failure are well described manifestations which are usually preceded by constitutional symptoms, limb claudication, pulse and blood pressure discrepancies, vascular bruits and features of organ ischaemia.

Case Presentation: A 25-year- old Sri Lankan female presented with a three days history of acute shortness of breath, cough and orthopnoea. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0028-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390538PMC
July 2018
3 Reads

A case report of REM sleep behavior disorder, Behcet's disease, Sjogren's syndrome and cognitive dysfunction.

BMC Rheumatol 2018 2;2:19. Epub 2018 Jul 2.

1Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044 People's Republic of China.

Background: Behcet's disease and Sjogren's syndrome is an autoimmune disorder from which many systems of the body can suffer. Here we reported a patient with a history of Behcet's disease and Sjogren's syndrome in which REM sleep behavior disorder (RBD) was then detected by polysomnographic (PSG) monitoring.

Case Presentation: A 68-year-old male patient with a history of Behcet's disease and Sjogren's syndrome was diagnosed with RBD by clinical examination and video-PSG, and he also underwent a multiple sleep latency test and cerebral magnetic resonance imaging. Read More

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http://dx.doi.org/10.1186/s41927-018-0022-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390777PMC
July 2018
10 Reads

Perspectives of patients, first-degree relatives and rheumatologists on preventive treatments for rheumatoid arthritis: a qualitative analysis.

BMC Rheumatol 2018 5;2:18. Epub 2018 Jul 5.

2Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC Canada.

Background: There is growing evidence that it may be possible to identify people at high risk of developing rheumatoid arthritis (RA). Assuming that effective interventions were available, this could mean that treatments introduced in the pre-symptomatic phase could prevent or delay the onset of the disease. Our study aimed to identify the potential attributes involved in decision-making around whether or not to take preventive treatment for RA, in order to inform the development of a discrete choice experiment (DCE) to ascertain consumer preferences for a preventive treatment program for RA. Read More

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http://dx.doi.org/10.1186/s41927-018-0026-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390586PMC
July 2018
1 Read

Asymptomatic hyperuricemia and coronary flow reserve in patients with metabolic syndrome.

BMC Rheumatol 2018 20;2:17. Epub 2018 Jun 20.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02120 USA.

Background: Patients with metabolic syndrome (MetS) are at increased risk of asymptomatic hyperuricemia (i.e., elevated serum uric acid (SUA) level without gout) and cardiovascular disease. Read More

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http://dx.doi.org/10.1186/s41927-018-0027-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390615PMC
June 2018
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Pain, sleep and emotional well-being explain the lack of agreement between physician- and patient-perceived remission in early rheumatoid arthritis.

BMC Rheumatol 2018 26;2:16. Epub 2018 Jun 26.

2Department of Rheumatology, Amsterdam Rheumatology and immunology Center | VU University Medical Center, Amsterdam, Netherlands.

Background: Clinical response and remission are defined in multiple ways and measured with different instruments, resulting in substantial variation of the proportion of patients classified as being in remission. Therefore, the agreement between patient-perceived, physician-perceived remission and clinical response and remission definitions was determined in early rheumatoid arthritis (RA) patients. And secondly, differences in clinical and patient-reported outcomes, in patients in physician-perceived remission, between patients in and not in self-perceived remission were assessed. Read More

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http://dx.doi.org/10.1186/s41927-018-0024-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390551PMC

Living with osteoarthritis is a balancing act: an exploration of patients' beliefs about knee pain.

BMC Rheumatol 2018 12;2:15. Epub 2018 Jun 12.

5Department of Surgical Sciences, University of Otago, Dunedin, New Zealand.

Background: This study aimed to explore the beliefs of people with knee osteoarthritis (OA) about the disease, and how these beliefs had formed and what impact these beliefs had on activity participation, health behaviour, and self-management.

Methods: Semi-structured interviews were conducted with 13 people with knee OA recruited from general practices, community physiotherapy clinics, and public advertisements in two provinces of New Zealand. Data were analysed using Interpretive Description. Read More

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http://dx.doi.org/10.1186/s41927-018-0023-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390552PMC
June 2018
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An evaluation of gout visits in the United States for the years 2007 to 2011.

BMC Rheumatol 2018 30;2:14. Epub 2018 May 30.

Campbell University College of Pharmacy & Health Sciences, 180 Main Street PO Box 1090, Buies Creek, NC 27506 USA.

Background: This study analyzed visits for and factors associated with gout and gout medication treatment trends for the years 2007-2011 in the United States given the introduction of febuxostat, the first new treatment option for gout in over 40 years, which was introduced to the market in 2009.

Methods: This study was a retrospective, cross-sectional, observational study of patients age 20 and older seen by providers who participated in the National Ambulatory Medical Care Survey (NAMCS), the National Hospital Ambulatory Medical Care Survey Outpatient Department (NHAMCS-OPD) or Emergency Department (NHAMCS-ED) in the United States. The outcome of interest was visits for gout diagnosis and visits where a gout medication was prescribed. Read More

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http://dx.doi.org/10.1186/s41927-018-0020-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390619PMC
May 2018
2 Reads

A prospective, open-label, non-comparative study of ambrisentan with anti-fibrotic agent combination therapy in the treatment of diffuse systemic sclerosis.

BMC Rheumatol 2018 15;2:13. Epub 2018 May 15.

1Hospital of the University of Pennsylvania, Philadelphia, USA.

Background: Systemic Sclerosis is a multifactorial autoimmune rheumatic disease characterized by inflammation, fibrosis, immune dysregulation and vascular dysfunction.

Methods: An open label, prospective, non-comparative study evaluating ambrisentan with an antifibrotic agent in diffuse cutaneous systemic sclerosis (dcSSc). Recruited 15 consecutive patients with dcSSc who were already on a stable dose of an antifibrotic agent and if they met inclusion criteria they were initiated on ambrisentan 5 mg/day for 12 months. Read More

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http://dx.doi.org/10.1186/s41927-018-0021-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390567PMC
May 2018
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Antibody response to 13-valent pneumococcal conjugate vaccine is not impaired in patients with rheumatoid arthritis or primary Sjögren's syndrome without disease modifying treatment.

BMC Rheumatol 2018 5;2:12. Epub 2018 Apr 5.

Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Skåne University Hospital, SE-221 85 Lund, Sweden.

Background: Pneumococcal vaccination is recommended to patients with rheumatoid arthritis (RA) and primary Sjögren's syndrome (pSS). However, little is known whether the diseases influence pneumococcal vaccine response. This study aimed to investigate antibody response and functionality of antibodies following immunization with 13-valent pneumococcal conjugate vaccine (PCV13) in RA patients or pSS patients without disease modifying anti-rheumatic drugs (DMARD), compared to patients with RA treated with DMARD or to healthy controls. Read More

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http://dx.doi.org/10.1186/s41927-018-0019-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390610PMC
April 2018
5 Reads

Prevalence of chronic widespread pain in a population-based cohort of patients with spondyloarthritis - a cross-sectional study.

BMC Rheumatol 2018 5;2:11. Epub 2018 Apr 5.

2Department of Clinical Sciences Lund,Rheumatology, Lund University, Faculty of Medicine, Lund, Sweden.

Background: Chronic pain, regional or widespread, is a frequent and multidimensional symptom in arthritis. There is still limited information on chronic pain in spondyloarthritis, which is important to recognize for adequate diagnosis and treatment. Our objective was to study differences in prevalence of chronic widespread pain in two spondyloarthritis subgroups: ankylosing spondylitis (AS) and undifferentiated spondyloarthritis (USpA). Read More

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http://dx.doi.org/10.1186/s41927-018-0018-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390534PMC
April 2018
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Cardiovascular co-morbidity in patients with rheumatoid arthritis: a narrative review of risk factors, cardiovascular risk assessment and treatment.

BMC Rheumatol 2018 11;2:10. Epub 2018 Apr 11.

2Joan and Sanford I Weill Medical College of Cornell University, Division of General Internal Medicine, 525 East 68th Street, F-2019, PO Box #331, New York, NY 10065 USA.

Cardiovascular disease (CVD) is markedly increased in patients with rheumatoid arthritis partly due to accelerated atherosclerosis from chronic inflammation. Traditional cardiovascular risk factors such as hypertension, hyperlipidemia, smoking, diabetes mellitus and physical inactivity are also highly prevalent among patients with rheumatoid arthritis (RA) and contribute to the CVD risk. The impact of traditional risk factors on the CVD risk appears to be different in the RA and non-RA population. Read More

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https://bmcrheumatol.biomedcentral.com/articles/10.1186/s419
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http://dx.doi.org/10.1186/s41927-018-0014-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390616PMC
April 2018
3 Reads

How do patients with systemic autoimmune rheumatic disease perceive the use of their medications: a systematic review and thematic synthesis of qualitative research.

BMC Rheumatol 2018 2;2. Epub 2018 Apr 2.

1University of British Columbia, Faculty of Pharmaceutical Sciences, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3 Canada.

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http://dx.doi.org/10.1186/s41927-018-0017-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390776PMC
April 2018
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Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis.

BMC Rheumatol 2018 23;2. Epub 2018 Mar 23.

1Arthritis Research UK Pain Centre, NIHR Nottingham Biomedical Research Centre & Division of Rheumatology Orthopaedics and Dermatology, University of Nottingham Clinical Sciences Building, City Hospital, Nottingham, NG5 1PB UK.

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http://dx.doi.org/10.1186/s41927-018-0016-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390559PMC
March 2018
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High prevalence of protein tyrosine phosphatase non-receptor N22 gene functional variant R620W in systemic lupus erythematosus patients from Kuwait: implications for disease susceptibility.

BMC Rheumatol 2018 16;2. Epub 2018 Mar 16.

3Department of Pediatrics, Faculty of Medicine, Kuwait University, P. O. Box 24923, 13110 Safat, Kuwait.

Background: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease which involves the loss of self-tolerance with hyperactivation of autoreactive T- and B-cells. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) encodes for lymphoid specific phosphatase (LYP) which is a key negative regulator of T lymphocyte activation. The aim of this study was to investigate the association between gene functional variant R620W and systemic lupus erythematosus (SLE) by comparing its prevalence in Kuwaiti SLE patients and controls. Read More

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http://dx.doi.org/10.1186/s41927-018-0015-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390595PMC
March 2018
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Methotrexate therapy impacts on red cell distribution width and its predictive value for cardiovascular events in patients with rheumatoid arthritis.

BMC Rheumatol 2018 7;2. Epub 2018 Mar 7.

1Department of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of Innsbruck, Anichstr. 35, A-6020 Innsbruck, Austria.

Background: Methotrexate (MTX) is well known to affect folic acid metabolism, so MTX treatment can result in alterations of mean corpuscular volume (MCV), which may impact on red cell distribution width (RDW), as MCV levels feed into RDW calculation. We thus questioned whether RDW levels and subsequently its diagnostic utility in RA subjects, as reported before, are influenced by ongoing MTX therapy.We assessed the impact of disease modifying drug (DMARD) treatment, especially MTX, on RDW and evaluated their influence on the predictive value of RDW for cardiovascular (CV) events in patients with rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1186/s41927-018-0012-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390531PMC
March 2018
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Rheumatoid Arthritis Portrayal by UK National Newspapers 2011-2016: A Service User - Led Thematic Analysis of Language Used.

BMC Rheumatol 2018 20;2. Epub 2018 Feb 20.

King's College London, Weston Education Centre, 10 Cutcombe Road, London, SE5 9RJ UK.

Background: An important source of knowledge, beliefs, and attitudes about illness is the mass media. Research has established the often negative and emotive language utilised by journalists to report on physical and mental long-term illnesses. The limited amount of research on rheumatological conditions has largely focused on the extent of, and/or accuracy of media coverage. Read More

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http://dx.doi.org/10.1186/s41927-018-0013-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390613PMC
February 2018

A phase II trial protocol of Tocilizumab in anti-TNF refractory patients with JIA-associated uveitis (the APTITUDE trial).

BMC Rheumatol 2018 27;2. Epub 2018 Feb 27.

5Department of Women's and Children's, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Background: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Children with JIA are at risk of intraocular inflammation (uveitis). In the initial stages of mild-moderate inflammation uveitis is asymptomatic. Read More

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http://dx.doi.org/10.1186/s41927-018-0010-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390576PMC
February 2018
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Network meta-analysis and cost per responder of targeted Immunomodulators in the treatment of active psoriatic arthritis.

BMC Rheumatol 2018 12;2. Epub 2018 Feb 12.

5AbbVie Inc., Mettawa, IL USA.

Background: Multiple targeted immunomodulators (TIMs) for psoriatic arthritis (PsA) treatment are available, but limited studies have directly compared these agents. This study indirectly compared the efficacy of TNF-α, interleukins, and phosphodiesterase-4 inhibitors for treatment of active PsA.

Methods: A systematic literature review was conducted to identify phase III randomized controlled trials (RCTs) for adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, ustekinumab, secukinumab, and apremilast in active PsA. Read More

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http://dx.doi.org/10.1186/s41927-018-0011-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390550PMC
February 2018
5 Reads

Perioperative medical management for patients with RA, SPA, and SLE undergoing total hip and total knee replacement: a narrative review.

BMC Rheumatol 2018 30;2. Epub 2018 Jan 30.

Department of Medicine, Weill Cornell Medical School, Division of Rheumatology Hospital for Special Surgery, 535 E 70th St, New York City, NY 10021 USA.

Total hip (THA) and total knee arthroplasty (TKA) are widely used, successful procedures for symptomatic end stage arthritis of the hips or knees, but patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and spondyloarthritis (SPA) including ankylosing spondylitis (AS) and psoriatic arthritis (PSA) are at higher risk for adverse events after surgery. Utilization rates of THA and TKA remain high for patients with RA, and rates of arthroplasty have increased for patients with SLE and SPA. However, complications such as infection are increased for patients with SLE, RA, and SPA, most of whom are receiving potent immunosuppressant medications and glucocorticoids at the time of surgery. Read More

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http://dx.doi.org/10.1186/s41927-018-0008-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390575PMC
January 2018
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Radiographic progression in early rheumatoid arthritis patients following initial combination versus step-up treat-to-target therapy in daily clinical practice: results from the DREAM registry.

BMC Rheumatol 2018 17;2. Epub 2018 Jan 17.

1Arthritis Center Twente, Department of Rheumatology, Medisch Spectrum Twente, PO BOX 50 000, 7500 KA Enschede, The Netherlands.

Background: Early and intensive targeted treatment with disease modifying anti-rheumatic drugs (DMARDs) has been shown to lead to substantial reductions in disease activity and radiograph damage in patients with early rheumatoid arthritis (RA). The aim of this quasi-experimental study was to compare the first-year radiographic progression rates between a treat-to-target (T2 T) strategy with initial combination therapy (strategy II, started in 2012) versus an initial step-up monotherapy (strategy I, started in 2006).

Methods: A total of 128 patients from strategy II was individually matched with 128 patients from strategy I on sex, age (± 5 yrs. Read More

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http://dx.doi.org/10.1186/s41927-018-0009-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390778PMC
January 2018
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Possible giant cell arteritis symptoms are common in newly diagnosed patients with Polymyalgia Rheumatica: results from an incident primary care PMR cohort.

BMC Rheumatol 2017 13;1. Epub 2017 Dec 13.

1Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele University, Keele, Staffordshire, ST5 5BG UK.

Background: To examine the frequency of possible giant cell arteritis (GCA) symptoms (including headache, temporal/scalp tenderness, jaw claudication and visual symptoms) in newly diagnosed polymyalgia rheumatica (PMR) patients in UK primary care.

Methods: The PMR Cohort Study is a primary care inception cohort of 652 adults with newly diagnosed polymyalgia rheumatica (PMR). At baseline, participants were asked to report (yes/no) on the presence of seven potential GCA symptoms: sudden headache, tender scalp, disturbed/double vision, jaw claudication, fever, appetite loss and unintentional weight loss. Read More

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http://dx.doi.org/10.1186/s41927-017-0007-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390563PMC
December 2017
1 Read