2,428 results match your criteria BMC pediatrics[Journal]


Parental age and developmental milestones: pilot study indicated a role in understanding ADHD severity in Indian probands.

BMC Pediatr 2019 Apr 22;19(1):117. Epub 2019 Apr 22.

Manovikas Biomedical Research and Diagnostic Centre, Manovikas Kendra, 482, Madudah, Plot I-24, Sec.-J, E.M. Bypass, Kolkata, 700107, India.

Background: In different ethnic groups, birth related factors have shown significant influence in the etiology of Attention deficit hyperactivity disorder (ADHD). Based on these interesting findings, we aimed to investigate association between different pre- and post natal variables and ADHD associated traits in Indian subjects.

Methods: ADHD Probands recruited based on the DSM-IV, were assessed by the Conner's Parent Rating Scale for behavioral problem (BPr), inattention (IA), hyperactivity (HA) and ADHD index (AI). Read More

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http://dx.doi.org/10.1186/s12887-019-1483-xDOI Listing

Association between anxiety and aggression in adolescents: a cross-sectional study.

BMC Pediatr 2019 Apr 18;19(1):115. Epub 2019 Apr 18.

College of Pharmacy and Division of Life and Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul, 03760, South Korea.

Background: The purpose of this study was to investigate the relationship between anxiety proneness and aggressive behavior in adolescents.

Methods: A quantitative, large scale cross-sectional study was conducted in Korea. The survey questionnaire included general health behavior and scales for assessing anxiety (Revised Children's Manifest Anxiety Scale; RCMAS) and aggressive behavior (The Aggression Questionnaire; AQ) in adolescents. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1479-6DOI Listing
April 2019
1 Read

Digenetic inheritance of SLC12A3 and CLCNKB genes in a Chinese girl with Gitelman syndrome.

BMC Pediatr 2019 Apr 18;19(1):114. Epub 2019 Apr 18.

The First Affiliated Hospital of Zhejiang University, Hangzhou, China.

Background: Gitelman syndrome (GS) is an autosomal recessive disorder and mild variant of classic Bartter syndrome. The latter is caused by defects in the genes CLCNKB and/or CLCNKA (chloride voltage-gated channel Ka and Kb). Patients with GS usually have loss-of-function mutations in SLC12A3. Read More

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http://dx.doi.org/10.1186/s12887-019-1498-3DOI Listing
April 2019
2 Reads

Parental smoking and blood pressure in children and adolescents: a national cross-sectional study in China.

BMC Pediatr 2019 Apr 18;19(1):116. Epub 2019 Apr 18.

Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, Xueyuan Road 38, Haidian District, Beijing, 100191, China.

Background: Current evidence on the health effects of passive smoking on childhood blood pressure is limited and inconsistent. We investigated the associations between exposure to parental smoking and blood pressure in children and adolescents.

Methods: A cross-sectional analysis was performed in a national sample of 42,745 children and adolescents (50. Read More

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http://dx.doi.org/10.1186/s12887-019-1505-8DOI Listing

Quick assessment with controlled attenuation parameter for hepatic steatosis in children based on MRI-PDFF as the gold standard.

BMC Pediatr 2019 Apr 15;19(1):112. Epub 2019 Apr 15.

Department of Radiology and Research Institute of Radiological Science, Severance Children's Hospital, Yonsei University College of Medicine, 50-1Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Background: Controlled attenuation parameter (CAP) is a recently introduced, non-invasive and quantitative method to evaluate hepatic steatosis demonstrated in adults, but limited in obesity and not well evaluated in children. The aim of this study was to investigate the diagnostic performance for assessing hepatic steatosis grades using CAP in children based on MR proton density fat fraction (PDFF).

Methods: Children evaluated for non-alcoholic fatty liver disease (NAFLD) who were assessed for PDFF and CAP were enrolled retrospectively. Read More

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http://dx.doi.org/10.1186/s12887-019-1485-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463656PMC
April 2019
1 Read

Household, maternal, and child related determinants of hemoglobin levels of Ethiopian children: hierarchical regression analysis.

BMC Pediatr 2019 Apr 15;19(1):113. Epub 2019 Apr 15.

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Anemia remains a major public health problem among children under five years old in Ethiopia, rising unexpectedly from 44% national prevalence in 2011 to 57% in 2016. In this study, we investigated the household, maternal and child-related dietary and non-dietary factors associated with hemoglobin (Hb) level of infants and young children.

Method: We analyzed data from a nationally representative sample of 2902 children aged 6-23 months, included in the 2016 Ethiopian demographic and health survey (EDHS). Read More

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http://dx.doi.org/10.1186/s12887-019-1476-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466676PMC

Enterostomy complications in necrotizing enterocolitis (NEC) surgery, a retrospective chart review at Odense University Hospital.

BMC Pediatr 2019 Apr 13;19(1):110. Epub 2019 Apr 13.

Surgical Department A, Odense University Hospital, J.B. Winsløws Vej 4, 5000, Odense C, Denmark.

Background: The aim was to investigate the incidence of postoperative complications to surgery for necrotizing enterocolitis (NEC) with primary focus on enterostomy related complications.

Methods: A retrospective chart review of surgically treated NEC during the period from 2008 to 2014 was performed. Enterostomy with secondary anastomosis was our standard treatment. Read More

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http://dx.doi.org/10.1186/s12887-019-1488-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461813PMC

Lethal perinatal hypophosphatasia caused by a novel compound heterozygous mutation: a case report.

BMC Pediatr 2019 Apr 13;19(1):109. Epub 2019 Apr 13.

Department of Neonatal Intensive Care Unit, The First Hospital of Tsinghua University, No. 6, Jiuxianqiao, Chaoyang District, Beijing, 100016, China.

Background: Hypophosphatasia (HPP) is a rare hereditary disorder characterized by defective bone and tooth mineralization and deficiency of tissue non-specific alkaline phosphatase (TNAP) activity. The clinical presentation of HPP is highly variable, and the prognosis for the infantile form is poor.

Case Presentation: This study reports a male infant diagnosed with lethal perinatal HPP. Read More

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http://dx.doi.org/10.1186/s12887-019-1478-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461808PMC

Survivorship care plan experiences among childhood acute lymphoblastic leukemia patients and their families.

BMC Pediatr 2019 Apr 13;19(1):111. Epub 2019 Apr 13.

Huntsman Cancer Institute, Cancer Control and Population Sciences, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA.

Background: As survivorship care plan (SCP) use among childhood cancer survivors and their families has not been extensively researched, we report on their experiences with receiving an SCP after the completion of therapy.

Methods: Eligible patients had acute lymphoblastic leukemia, completed therapy, and had no evidence of disease at enrollment. Patients aged 7 or older (N = 13) and at least one parent (N = 23 for 20 total patients) were surveyed and completed assessments at enrollment (Time 1, T1), SCP delivery (Time 2, T2), and follow-up (Time 3, T3) (retention 90. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1464-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461822PMC
April 2019
7 Reads

A screening tool for psychological difficulties in children aged 6 to 36 months: cross-cultural validation in Kenya, Cambodia and Uganda.

BMC Pediatr 2019 Apr 12;19(1):108. Epub 2019 Apr 12.

Epicentre, 8 rue Saint Sabin, 75011, Paris, France.

Background: In low-resource settings, the lack of mental health professionals and cross-culturally validated screening instruments complicates mental health care delivery. This is especially the case for very young children. Here, we aimed to develop and cross-culturally validate a simple and rapid tool, the PSYCa 6-36, that can be administered by non-professionals to screen for psychological difficulties among children aged six to 36 months. Read More

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http://dx.doi.org/10.1186/s12887-019-1461-3DOI Listing

Prospective audit and feedback on antibiotic use in neonatal intensive care: a retrospective cohort study.

BMC Pediatr 2019 Apr 11;19(1):105. Epub 2019 Apr 11.

Antimicrobial Stewardship Program, Sinai Health System-University Health Network, 600 University Avenue, Toronto, ON, M5G 1X5, Canada.

Background: Antimicrobial stewardship programs potentially lead to appropriate antibiotic use, yet the optimal approach for neonates is uncertain. Such a program was implemented in a tertiary care neonatal intensive care unit in October 2012. We evaluated the impact of this program on antimicrobial use and its association with clinical outcomes. Read More

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http://dx.doi.org/10.1186/s12887-019-1481-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458619PMC

Heterozygous familial hypercholesterolaemia in a pair of identical twins: a case report and updated review.

BMC Pediatr 2019 Apr 11;19(1):106. Epub 2019 Apr 11.

Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA (UiTM), Sungai Buloh Campus, Jalan Hospital, 47000, Sungai Buloh, Selangor, Malaysia.

Background: Familial hypercholesterolaemia (FH) is the most common inherited metabolic disease with an autosomal dominant mode of inheritance. It is characterised by raised serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c), leading to premature coronary artery disease. Children with FH are subjected to early and enhanced atherosclerosis, leading to greater risk of coronary events, including premature coronary artery disease. Read More

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http://dx.doi.org/10.1186/s12887-019-1474-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458607PMC
April 2019
1 Read

Parental support in promoting children's health behaviours and preventing overweight and obesity - a long-term follow-up of the cluster-randomised healthy school start study II trial.

BMC Pediatr 2019 Apr 11;19(1):104. Epub 2019 Apr 11.

Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden.

Background: Effects of obesity prevention interventions in early childhood are only meaningful if they are sustained over time, but long-term follow-up studies are rare. The school-based cluster-randomised Healthy School Start (HSS) trial aimed at child health promotion and obesity prevention through parental support was carried out in 31 pre-school classes (378 families) in disadvantaged areas in Sweden during 2012-2013. Post-intervention results showed intervention effects on intake of unhealthy foods and drinks, and lower BMI-sds in children with obesity at baseline. Read More

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http://dx.doi.org/10.1186/s12887-019-1467-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458763PMC
April 2019
1.918 Impact Factor

The prevalence of premature thelarche in girls and gynecomastia in boys and the associated factors in children in Southern China.

BMC Pediatr 2019 Apr 11;19(1):107. Epub 2019 Apr 11.

Department of Endocrinology, Children's Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, China.

Background: To investigate the prevalence and risk factors of premature thelarche (PT) in girls and gynecomastia (GM) in boys in Southern China.

Methods: We conducted a cross-sectional study of preschool children across 9 cities in Zhejiang province. A total of 6273 children in the age-group of 2-7 years were recruited from January 2014 to March 2015. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1426-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458611PMC
April 2019
2 Reads

Muscle fitness and its association with body mass index in children and adolescents aged 7-18 years in China: a cross-sectional study.

BMC Pediatr 2019 Apr 10;19(1):101. Epub 2019 Apr 10.

Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 5 Dongdansantiao, Dongcheng District, Beijing, 100005, China.

Background: The present study was the first one aimed to investigate the current muscle fitness and its associated factors among children and adolescents in mainland China.

Methods: From Nov 2013 to Jul 2014, 2283 children and adolescents aged 7-18 were recruited in Hainan and Shaanxi Provinces in China by cross-sectional design. Information on anthropometry and muscle fitness, measured by hand grip strength (GS), vertical jump (VJ) and sit-and-reach (SR), were collected. Read More

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http://dx.doi.org/10.1186/s12887-019-1477-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456985PMC
April 2019
1.918 Impact Factor

Misdiagnosis of scrub typhus complicated by hemophagocytic syndrome.

BMC Pediatr 2019 Apr 10;19(1):102. Epub 2019 Apr 10.

Second Affiliated Hospital of Wenzhou Medical University, Wen Zhou, China.

Background: This study sought to analyze the cases of clinical misdiagnosis of scrub typhus complicated by hemophagocytic syndrome.

Methods: We retrospectively reviewed the medical records for diagnoses, clinical course, chest X-ray findings, laboratory data, and antibiotic therapy.

Results: All nine patients were misdiagnosed at the outpatient department between 07/2009 and 07/2017. Read More

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http://dx.doi.org/10.1186/s12887-019-1475-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458710PMC
April 2019
1 Read

Obesity and understudied minority children: existing challenges and opportunities in epidemiology.

BMC Pediatr 2019 Apr 10;19(1):103. Epub 2019 Apr 10.

Department of Epidemiology, Emory University, CNR 3rd floor, 1518 Clifton Road, NE, Atlanta, GA, 30322, USA.

Background: Obesity is a major public health concern in the United States and should be addressed as early as possible, in childhood. Disparities exist in obesity prevalence and its associated comorbidities by racial/ethnic group, however less is known about the smaller racial/ethnic subclasses that are often aggregated and assumed to be homogeneously at risk. As the racial and ethnic composition of the US shifts towards greater diversity, it is important that epidemiologic research addresses these new challenges. Read More

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http://dx.doi.org/10.1186/s12887-019-1484-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458765PMC

Assessing the role of family well-being on the quality of life of Indian children with thalassemia.

BMC Pediatr 2019 Apr 8;19(1):100. Epub 2019 Apr 8.

School of Public Health, SRM University, Chennai, India.

Background: The association between chronic diseases and psychological problems is well established. As thalassemia is chronic blood disorder with burdensome treatment procedures, patients are likely to have psychological health problems. Many studies reported evidences regarding the quality of life. Read More

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http://dx.doi.org/10.1186/s12887-019-1466-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454746PMC

Allometric scaling of aerobic fitness outputs in school-aged pubertal girls.

BMC Pediatr 2019 Apr 8;19(1):96. Epub 2019 Apr 8.

Study and Research Group in Physical Activity and Exercise (GEPAFE), State University of Londrina (UEL), Londrina, Paraná, Brazil.

Background: This study aimed to determine the allometric exponents for concurrent size descriptors (stature, body mass and fat-free mass) and also to examine the contribution of chronological age and pubertal status combined with above mentioned size descriptors to explain inter-individual variability in the peak of oxygen uptake (VO) among girls during circumpubertal years.

Methods: The final sample included 51 girls (10.7-13. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1462-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452511PMC
April 2019
4 Reads

Cleidocranial dysplasia syndrome with epilepsy: a case report.

BMC Pediatr 2019 Apr 8;19(1):97. Epub 2019 Apr 8.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.

Background: Cleidocranial dysplasia is a rare autosomal dominant disorder resulting in skeletal and dental abnormalities due to the disturbance in ossification of the bones. The prevalence of CCD is one in a million of live births, and epileptic seizures are rarer in this disease.

Case Presentation: Herein, we present a case of a 10-year-old girl, who not only suffered with cleidocranial dysplasia, but experienced frequent seizures. Read More

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http://dx.doi.org/10.1186/s12887-019-1472-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452517PMC

From uncertainty to gradually managing and awaiting recovery of a periodic condition- a qualitative study of parents´ experiences of PFAPA syndrome.

BMC Pediatr 2019 Apr 8;19(1):99. Epub 2019 Apr 8.

Department of Pediatrics, NU-Hospital Group, Uddevalla, Sweden.

Background: The prevalence of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is unknown. Although an uncommon condition, it is considered to be the most common autoinflammatory disease among children in many parts of the world. The knowledge of the consequences of the recurrent fever episodes for the child and its family are limited. Read More

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http://dx.doi.org/10.1186/s12887-019-1458-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454720PMC

Compound heterozygous POMGNT1 mutations leading to muscular dystrophy-dystroglycanopathy type A3: a case report.

BMC Pediatr 2019 Apr 8;19(1):98. Epub 2019 Apr 8.

Genotek Ltd, Nastavnicheskii pereulok 17/1, 105120, Moscow, Russia.

Background: Dystroglycanopathies, which are caused by reduced glycosylation of alpha-dystroglycan, are a heterogeneous group of neurodegenerative disorders characterized by variable brain and skeletal muscle involvement. Muscle-eye-brain disease (or muscular dystrophy-dystroglycanopathy type 3 A) is an autosomal recessive disorder characterized by congenital muscular dystrophy, ocular abnormalities, and lissencephaly.

Case Presentation: We report clinical and genetic characteristics of a 6-year-old boy affected by muscular dystrophy-dystroglycanopathy. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1470-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454623PMC
April 2019
3 Reads

An atypical case of Klippel-Trénaunay syndrome presenting with crossed-bilateral limb hypertrophy and postaxial polydactyly: a case report.

BMC Pediatr 2019 Apr 6;19(1):95. Epub 2019 Apr 6.

Division of Neonatology, Department of Pediatrics, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

Background: Klippel-Trénaunay syndrome (KTS) is a rare congenital condition characterized by the clinical triad of capillary malformations (port wine stains), varicose veins with or without venous malformations, and bony and/or soft tissue hypertrophy.

Case Presentation: Here we report the first case of a one-day-old male with KTS presenting with crossed-bilateral limb hypertrophy and post-axial polydactyly.

Conclusion: This case serves to highlight the variable presentation and multiple problems faced by patients with KTS and why multidisciplinary management is mandatory. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1480-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451243PMC
April 2019
3 Reads

Paths to language development in at risk children: a qualitative comparative analysis (QCA).

BMC Pediatr 2019 Apr 5;19(1):94. Epub 2019 Apr 5.

School of Nursing and Midwifery, Western Sydney University, Sydney, NSW, Australia.

Background: Childhood language development is related to long term educational, employment, health and social outcomes. Previous research identifies a complex range of risk and protective factors which result in good and poor language outcomes for children, however children at risk are an underrepresented group in these studies. Our aim is to investigate the combinations of factors (paths) that result in good and poor language outcomes for a group of 5 year old children of mothers experiencing adversity. Read More

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http://dx.doi.org/10.1186/s12887-019-1449-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449893PMC
April 2019
1 Read

Rasopathies case report: concurrence of two pathogenic variations de novo in NF1 and KRAS genes in a patient.

BMC Pediatr 2019 Apr 5;19(1):92. Epub 2019 Apr 5.

Neonatology Department, Miguel Servet Children's Hospital, Isabel la Católica Avenue 1-3, 50009, Zaragoza, Spain.

Background: Rasopathies are a group of genetic malformative syndromes including neurofibromatosis 1, Noonan, LEOPARD, Costello, cardio-facio-cutaneous, Legius, and capillary malformation-arteriovenous malformation syndromes.

Case Presentation: We present a female newborn that consulted at the emergency department with refusal to eat and sleepiness. A shortened femur, thickened nucal fold and suspect for agenesis of the corpus callosum were observed in prenatal ultrasound. Read More

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http://dx.doi.org/10.1186/s12887-019-1463-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449997PMC
April 2019
1 Read

Multilevel analysis of individual, household, and community factors influencing child growth in Nepal.

BMC Pediatr 2019 Apr 5;19(1):91. Epub 2019 Apr 5.

Department of Agricultural Economics, Purdue University, West Lafayette, IN, 47907, USA.

Background: Childhood malnutrition and growth faltering is a serious concern in Nepal. Studies of child growth typically focus on child and mother characteristics as key factors, largely because Demographic and Health Surveys (DHS) collect data at these levels. To control for and measure the importance of higher-level factors this study supplements 2006 and 2011 DHS data for Nepal with data from coincident rounds of the Nepal Living Standards Surveys (NLSS). Read More

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http://dx.doi.org/10.1186/s12887-019-1469-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449894PMC
April 2019
1 Read

Delayed appearance of mature ganglia in an infant with an atypical presentation of total colonic and small bowel aganglionosis: a case report.

BMC Pediatr 2019 Apr 5;19(1):93. Epub 2019 Apr 5.

Division of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Alway Building M116, MC: 5733, Stanford, CA, 94305, USA.

Background: Total colonic and small bowel aganglionosis (TCSA) occurs in less than 1% of all Hirschsprung's disease patients. Currently, the mainstay of treatment is surgery. However, in patients with TCSA, functional outcomes are often poor. Read More

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http://dx.doi.org/10.1186/s12887-019-1456-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449943PMC
April 2019
1 Read

Changes in objectively measured physical activity after a multidisciplinary lifestyle intervention in children with abdominal obesity: a randomized control trial.

BMC Pediatr 2019 Apr 4;19(1):90. Epub 2019 Apr 4.

Paediatric Endocrinology Unit, Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Spain.

Background: Physical activity (PA) is associated with changes in body composition that affect insulin sensitivity and leptin levels. Few studies have assessed the effect of lifestyle interventions on changes in objectively measured PA levels in obese children. To evaluate the effects of a multidisciplinary lifestyle intervention on anthropometric indices, biochemical parameters and accelerometer measured PA in abdominal obese children. Read More

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http://dx.doi.org/10.1186/s12887-019-1468-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448302PMC
April 2019
1 Read

Does education offset the effect of maternal disadvantage on childhood anaemia in Tanzania? Evidence from a nationally representative cross-sectional study.

BMC Pediatr 2019 Apr 3;19(1):89. Epub 2019 Apr 3.

Demography and Population Studies Programme, Schools of Social Sciences and Public Health, University of the Witwatersrand, Johannesburg, South Africa.

Background: Despite being preventable, anaemia is a major public health problem that affects a sizable number of children under-five years globally and in Tanzania. This study examined the maternal factors associated with the risk of anaemia among under-five children in Tanzania. We also assessed whether higher maternal education could reduce the risks of anaemia among children of women with poor socio-economic status. Read More

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http://dx.doi.org/10.1186/s12887-019-1465-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446256PMC
April 2019
1 Read

Prevalence, risk factors and outcome of congenital anomalies among neonatal admissions in OGBOMOSO, Nigeria.

BMC Pediatr 2019 Apr 3;19(1):88. Epub 2019 Apr 3.

Department of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Nigeria.

Background: Congenital anomalies (CA) are a major cause of neonatal morbidity and mortality, especially in developing countries. Data on these anomalies are still poorly collated in developing countries. We aimed to assess the prevalence, pattern, risk factors and outcome of congenital anomalies among neonatal admissions in Ogbomoso Town, Nigeria. Read More

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http://dx.doi.org/10.1186/s12887-019-1471-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446329PMC

Evaluation of biochemical and haematological changes in dengue fever and dengue hemorrhagic fever in Sri Lankan children: a prospective follow up study.

BMC Pediatr 2019 Apr 1;19(1):87. Epub 2019 Apr 1.

Department of Pediatrics, Faculty of Medicine, Colombo, Sri Lanka.

Background: Series of biochemical and haematological changes occur during the course of dengue infection, which vary depending on the clinical disease. The patterns of change are not well documented and identifying these patterns in children with dengue infection would help to anticipate the progression to different clinical stages thus enabling effective management.

Methods: A prospective follow up study was conducted during the period of July 2013 - April 2014 at Professorial Pediatric unit, Lady Ridgeway Hospital for Children, Colombo, Sri Lanka. Read More

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http://dx.doi.org/10.1186/s12887-019-1451-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442420PMC
April 2019
1 Read

Congenital emphysematous lung disease associated with a novel Filamin A mutation. Case report and literature review.

BMC Pediatr 2019 Mar 29;19(1):86. Epub 2019 Mar 29.

Pediatrics and Adolescentology Unit, Department of Internal Medicine University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Background: Progressive lung involvement in Filamin A (FLNA)-related cerebral periventricular nodular heterotopia (PVNH) has been reported in a limited number of cases.

Case Presentation: We report a new pathogenic FLNA gene variant (c.7391_7403del; p. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1460-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440113PMC
March 2019
3 Reads

EIF2AK3 novel mutation in a child with early-onset diabetes mellitus, a case report.

Authors:
Tarah H Fatani

BMC Pediatr 2019 Mar 28;19(1):85. Epub 2019 Mar 28.

Department of Pediatrics, Section of Pediatric Endocrinology, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.

Background: Wolcott-Rallison syndrome (WRS) is caused by a biallelic mutation in the gene encoding eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) on chromosome 2p11.2. This condition is characterized by permanent early-onset diabetes mellitus, epiphyseal dysplasia, and hepatic dysfunction. Read More

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http://dx.doi.org/10.1186/s12887-019-1432-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438019PMC
March 2019
1 Read

Clinically relevant body composition methods for obese pediatric patients.

BMC Pediatr 2019 Mar 21;19(1):84. Epub 2019 Mar 21.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Pulmology, Allergology and Endocrinology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: There is no gold standard in body composition measurement in pediatric patients with obesity. Therefore, the aim of this study was to investigate if there are any differences between two bioelectrical impedance analysis techniques performed in children and adolescents with obesity.

Methods: Data were collected at the Department of Pediatrics and Adolescent Medicine in Vienna from September 2015 to May 2017. Read More

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http://dx.doi.org/10.1186/s12887-019-1454-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427859PMC

Ogilvie syndrome in a 8 year old girl after laparoscopic appendectomy.

BMC Pediatr 2019 Mar 20;19(1):82. Epub 2019 Mar 20.

Pediatrics, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.

Background: Ogilvie's syndrome is described in the adult population, but rarely seen in children.

Case Presentation: We present a case of a girl who suffered acute colonic pseudo-obstruction after laparoscopic appendectomy.

Conclusions: Ogilvie's syndrome, although rare in the pediatric population, should be considered as possible diagnosis after a surgical procedure in presence of persisting subocclusive symptoms and radiological signs of massive colonic dilatation without mechanical obstruction. Read More

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http://dx.doi.org/10.1186/s12887-019-1457-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425584PMC
March 2019
1 Read

Maternal characteristics and nutritional status among 6-59 months of children in Ethiopia: further analysis of demographic and health survey.

BMC Pediatr 2019 Mar 20;19(1):83. Epub 2019 Mar 20.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Background: Nutritional status of children influences their health status, which is a key determinant of human development. In Ethiopia, 28% of child mortality is caused by under nutrition. There is also some controversial evidence about the association between maternal characteristics and nutritional status of under five children. Read More

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http://dx.doi.org/10.1186/s12887-019-1459-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425564PMC

Randomized controlled trial protocol to improve multisensory neural processing, language and motor outcomes in preterm infants.

BMC Pediatr 2019 Mar 19;19(1):81. Epub 2019 Mar 19.

Nationwide Children's Hospital Division of Neonatology & Center for Perinatal Research, The Ohio State University, 5th floor; 575 Children's Crossroads, Columbus, OH, 43215, USA.

Background: Premature infants are at risk for abnormal sensory development due to brain immaturity at birth and atypical early sensory experiences in the Neonatal Intensive Care Unit. This altered sensory development can have downstream effects on other more complex developmental processes. There are currently no interventions that address rehabilitation of sensory function in the neonatal period. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1455-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423745PMC
March 2019
2 Reads

A newborn with seizures born to a mother diagnosed with primary carnitine deficiency.

BMC Pediatr 2019 Mar 18;19(1):79. Epub 2019 Mar 18.

Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang, 325027, Wenzhou, China.

Background: Maternofetal carnitine transport through the placenta is the main route of fetal carnitine uptake. Decreased free carnitine levels discovered by newborn screening has identified many asymptomatic adult women with systemic primary carnitine deficiency (PCD). Here, we presented amplitude integrated electroencephalogram (aEEG) and magnetic resonance imaging (MRI) findings from a neonate with epilepsy whose mother was carnitine deficient. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1452-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421665PMC
March 2019
5 Reads

Dysmenorrhea among high-school students and its associated factors in Kuwait.

BMC Pediatr 2019 Mar 18;19(1):80. Epub 2019 Mar 18.

Department of Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Box: 24923, 13110, Safat, Kuwait.

Background: Although dysmenorrhea is not a life-threatening condition, it can cause a substantial burden on individuals and communities. There is no data on the prevalence of dysmenorrhea in Kuwait. This study aimed to estimate the prevalence of dysmenorrhea among female public high-school students in Kuwait and investigate factors associated with dysmenorrhea. Read More

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http://dx.doi.org/10.1186/s12887-019-1442-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421654PMC
March 2019
3 Reads

Overweight trajectory and cardio metabolic risk factors in young adults.

BMC Pediatr 2019 Mar 11;19(1):75. Epub 2019 Mar 11.

Postgraduate Program in Epidemiology, Federal University of Pelotas, Caixa postal 354, Marechal Deodoro, 1160, Pelotas, RS, 96020-220, Brazil.

Background: Obesity is one of the conditions that increases the risk of cardiovascular disease. Studies about obesity trajectory and cardio metabolic outcomes at adulthood are still scarce. Therefore, we aimed to assess the association between patterns of overweight over the life-course and cardio metabolic risk factors in young adults. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1445-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410517PMC
March 2019
7 Reads

Sensation seeking in 3- to 6-year-old children: associations with socio-demographic parameters and behavioural difficulties.

BMC Pediatr 2019 Mar 11;19(1):77. Epub 2019 Mar 11.

LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany.

Background: The present study investigates whether sensation seeking in pre-school-age children is associated with age, gender and socio-economic status, and how sensation seeking relates to behavioural difficulties.

Methods: The study sample consisted of 423 three- to six-year-old children whose parents had completed questionnaires on the children's sensation seeking (Sensation Seeking Scale for Young Children), socio-economic status, and behavioural difficulties (Strengths and Difficulties Questionnaire). Multiple linear regression models were applied to investigate associations between sensation seeking and age, gender, socio-economic status and behavioural difficulties. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1450-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410503PMC
March 2019
4 Reads

Development of a web-based assessment tool that evaluates the meal situation when a child has a percutaneous endoscopic gastrostomy.

BMC Pediatr 2019 Mar 11;19(1):76. Epub 2019 Mar 11.

Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Box 457, 405 30, Gothenburg, Sweden.

Background: Children with cancer often suffer side effects from their treatment, for example nausea and vomiting, which can lead to malnutrition. If a child cannot eat orally, a percutaneous endoscopic gastrostomy (PEG) can improve his or her well-being, psychosocial development and growth by enabling the supply of nourishment and facilitating the administration of necessary medicines. Few data exist on children's comfort when using a PEG. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
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http://dx.doi.org/10.1186/s12887-019-1447-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410499PMC
March 2019
5 Reads

Case report: Cholecystoduodenostomy for cholestatic liver disease in a premature infant with cystic fibrosis and short gut syndrome.

BMC Pediatr 2019 Mar 11;19(1):78. Epub 2019 Mar 11.

Discipline of Paediatrics, School of Women's and Children's Health, Medicine, University of New South Wales, Sydney, NSW, Australia.

Background: Cholecystoduodenostomy is a surgical procedure that bypasses the extrahepatic biliary tree and connects the gallbladder directly to the duodenum. This case describes the successful use of this procedure in a novel situation.

Case Presentation: A premature (34 weeks gestation) female infant with cystic fibrosis required a laparotomy on day 1 of life due to an intrauterine small bowel perforation. Read More

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http://dx.doi.org/10.1186/s12887-019-1443-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410495PMC
March 2019
2 Reads

A case report of a challenging diagnosis of biliary atresia in a patient receiving total parenteral nutrition.

BMC Pediatr 2019 Mar 8;19(1):72. Epub 2019 Mar 8.

Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Background: Total parenteral nutrition (TPN) and biliary atresia (BA) are common causes of cholestasis in infancy. The diagnosis of BA is time sensitive due to an inverse correlation between age at intervention (hepatic portoenterostomy - HPE) and survival without liver transplantation. Clinical, laboratory, and histologic features of BA and parenteral nutrition associated cholestasis (PNAC) are similar, creating a diagnostic dilemma for cholestatic infants on parenteral nutrition. Read More

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http://dx.doi.org/10.1186/s12887-019-1446-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407171PMC
March 2019
1 Read

Is vitamin C enough? A case report of scurvy in a five-year-old girl and review of the literature.

BMC Pediatr 2019 Mar 8;19(1):74. Epub 2019 Mar 8.

Feeding Program, Penn State Hershey Medical Center, 905 W. Governor Road, Hershey, PA, 17033, USA.

Background: Numerous cases of scurvy secondary to diet limitations have been reported in the literature with most being boys with special needs. To date, the focus of the literature describing vitamin C deficiency has been the medical sequelae of the deficiency. There has been little attention given underlying diet limitations causing the vitamin C deficiency. Read More

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http://dx.doi.org/10.1186/s12887-019-1437-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408840PMC
March 2019
2 Reads

Rare cause of Hemophagocytic Lymphohistiocytosis due to mutation in PRF1 and SH2D1A genes in two children - a case report with a review.

BMC Pediatr 2019 Mar 8;19(1):73. Epub 2019 Mar 8.

FRIGE's Institute of Human Genetics, FRIGE House, Jodhpur Gam Road, Satellite, Ahmedabad, Gujarat, 380015, India.

Background: Hemophagocytic Lymphohistiocytosis (HLH) is a rare, complex, life-threatening hyper-inflammatory condition due to over activation of lymphocytes mediated secretory cytokines in the body. It occurs as a primary HLH due to genetic defect that mostly occurs in the childhood and associated with early neonatal death. Secondary HLH is triggered by secondary to infection and can occur at any age. Read More

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http://dx.doi.org/10.1186/s12887-019-1444-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407181PMC
March 2019
1 Read

Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children.

BMC Pediatr 2019 Mar 7;19(1):71. Epub 2019 Mar 7.

Department of Pediatrics, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat-13110, Jabriya, Kuwait.

Background: The incidence of type 1 diabetes mellitus (T1DM) in Kuwait is amongst the highest in the world. Vitamin D is considered to be involved in immune modulation and its deficiency contribute to autoimmune destruction of insulin producing beta cells in T1DM patients. Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility. Read More

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http://dx.doi.org/10.1186/s12887-019-1448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404350PMC
March 2019
1 Read

Effect of maternal smoking in pregnancy and childhood on child and adolescent sleep outcomes to 21 years: a birth cohort study.

BMC Pediatr 2019 Mar 6;19(1):70. Epub 2019 Mar 6.

School of Public Health, The University of Queensland, QLD, Brisbane, 4006, Australia.

Background: The effects of prenatal maternal smoking have been studied extensively, however little research has examined the effects of prenatal exposure to maternal smoking on offspring sleep, particularly over several developmental periods. We examined the effects of prenatal maternal smoking and postnatal smoking from birth to 14 years, on offspring sleep at 6 months, 5, 14 and 21 years.

Methods: This was a prospective, community-based birth cohort study involving 7223 women who delivered a singleton child in Brisbane, Australia between 1981 and 1983. Read More

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http://dx.doi.org/10.1186/s12887-019-1439-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402153PMC
March 2019
2 Reads
1.918 Impact Factor

Impact of birthweight on health-care utilization during early childhood - a birth cohort study.

BMC Pediatr 2019 Mar 1;19(1):69. Epub 2019 Mar 1.

Center for Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

Background: Comprehensive data are needed to evaluate the burden of low birthweight. Analysis of routine data on health-care utilization during early childhood were used to test the hypothesis that infants with low birthweight have (i) increased inpatient health-care utilization, (ii) higher hospital costs and (iii) different morbidity pattern in early childhood when compared with normal birthweight infants.

Methods: Children born between 2007 and 2013 that were insured at birth with the statutory health insurance AOK PLUS were included (N = 118,166, equaling 49% of the Saxon newborns) and classified into very low (< 1500 g, VLBW), low (1500-2499 g, LBW) birthweight and reference group (> 2500 g). Read More

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http://dx.doi.org/10.1186/s12887-019-1424-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397462PMC

Practice variation in anti-epileptic drug use for neonatal hypoxic-ischemic encephalopathy among regional NICUs.

BMC Pediatr 2019 Feb 27;19(1):67. Epub 2019 Feb 27.

Children's National Health Systems, Washington, DC, USA.

Background: While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systematically evaluated. This is important as these centers typically have multidisciplinary neonatal neurocritical care teams and protocolized approaches to treating conditions such as hypoxic ischemic encephalopathy (HIE), a population at high risk for neonatal seizures. To identify opportunities for quality improvement (QI), we evaluated ICV in AED utilization for neonates with HIE treated with therapeutic hypothermia (TH) across regional NICUs in the US. Read More

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https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-019-1441-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391819PMC
February 2019
9 Reads