1,812 results match your criteria BMC neuroscience[Journal]


Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain.

BMC Neurosci 2019 Apr 24;20(1):17. Epub 2019 Apr 24.

Battlefield Pain Management Research Group, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, San Antonio, TX, 78234-4504, USA.

Background: Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent stress (CIS) on nociceptive behaviors and brain-derived nerve growth factor (BDNF) system in the prefrontal cortex (PFC) and hypothalamus of rats with and without thermal injury. Read More

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http://dx.doi.org/10.1186/s12868-019-0500-1DOI Listing

Affective and cognitive behavior is not altered by chronic constriction injury in B7-H1 deficient and wildtype mice.

BMC Neurosci 2019 Apr 11;20(1):16. Epub 2019 Apr 11.

Department of Neurology, University of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Background: Chronic neuropathic pain is often associated with anxiety, depressive symptoms, and cognitive impairment with relevant impact on patients` health related quality of life. To investigate the influence of a pro-inflammatory phenotype on affective and cognitive behavior under neuropathic pain conditions, we assessed mice deficient of the B7 homolog 1 (B7-H1), a major inhibitor of inflammatory response.

Results: Adult B7-H1 ko mice and wildtype littermates (WT) received a chronic constriction injury (CCI) of the sciatic nerve, and we assessed mechanical and thermal sensitivity at selected time points. Read More

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http://dx.doi.org/10.1186/s12868-019-0498-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458735PMC

Assessing the protective effect of rosiglitazone against electronic cigarette/tobacco smoke-induced blood-brain barrier impairment.

BMC Neurosci 2019 Apr 4;20(1):15. Epub 2019 Apr 4.

Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, 1300 S. Coulter Street, Amarillo, TX, 79106, USA.

Background: Smoking (TS) and recently e-cigarettes (EC) vaping, have been associated with vascular endothelial dysfunction primarily relevant to oxidative stress, exposure to nicotine, and smoking-induced inflammation. It is accepted that both EC and TS enhance glucose intolerance and the risk of developing type-2 diabetes mellitus which is also one of the causes of blood-brain barrier (BBB) damage and the higher risk of cerebrovascular diseases. Recent studies have shown how Metformin, the first common antidiabetic drug, can protect the BBB integrity through enhancement of nuclear factor erythroid 2-related factor (Nrf2) activity. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-019-0497-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449906PMC
April 2019
3 Reads

Additive effect of 5-HT2C and CB1 receptor blockade on the regulation of sleep-wake cycle.

BMC Neurosci 2019 Mar 20;20(1):14. Epub 2019 Mar 20.

Department of Pharmacodynamics, Semmelweis University, Budapest, Nagyvárad tér 4, 1089, Hungary.

Background: Previous data show that serotonin 2C (5-HT) and cannabinoid 1 (CB) receptors have a role in the modulation of sleep-wake cycle. Namely, antagonists on these receptors promoted wakefulness and inhibited rapid eye movement sleep (REMS) in rodents. The interaction of these receptors are also present in other physiological functions, such as the regulation of appetite. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-019-0495-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427841PMC
March 2019
14 Reads

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease.

BMC Neurosci 2019 Mar 20;20(1):13. Epub 2019 Mar 20.

Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, 474-8511, Japan.

Background: Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogenic mechanisms of AD. Previously, we reported that App mice, which harbor three familial AD mutations (Swedish, Beyreuther/Iberian, and Arctic) exhibited emotional alterations before the onset of definitive cognitive deficits. To determine whether these mice exhibit deficits in learning and memory at more advanced ages, we compared the Morris water maze performance of App and App mice, which harbor only the Swedish mutation, with that of wild-type (WT) C57BL/6J mice at the age of 24 months. Read More

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http://dx.doi.org/10.1186/s12868-019-0496-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425634PMC

Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide.

BMC Neurosci 2019 Mar 18;20(1):11. Epub 2019 Mar 18.

Department of Psychiatry and Behavioral Science, The Johns Hopkins University School of Medicine, Baltimore, USA.

Background: Pre-treatment with the corticotropin-releasing factor antagonist α-helical CRF9-41 prevents inhibition of gastric emptying by cocaine-and amphetamine-regulated transcript peptide at a dorsal hindbrain level, but its inhibition of sucrose intake is not affected. This is suggestive of separable underlying mechanisms of action in the caudal brainstem for cocaine-and amphetamine-regulated transcript peptide with regard to food intake and gastrointestinal functions. Here we further examine cocaine-and amphetamine-regulated transcript peptide-corticotropin-releasing factor receptor interactions in caudal brainstem controls of solid food intake. Read More

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http://dx.doi.org/10.1186/s12868-019-0494-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421688PMC

Effect of lesion proximity on the regenerative response of long descending propriospinal neurons after spinal transection injury.

BMC Neurosci 2019 Mar 18;20(1):10. Epub 2019 Mar 18.

Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.

Background: The spinal cord is limited in its capacity to repair after damage caused by injury or disease. However, propriospinal (PS) neurons in the spinal cord have demonstrated a propensity for axonal regeneration after spinal cord injury. They can regrow and extend axonal projections to re-establish connections across a spinal lesion. Read More

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http://dx.doi.org/10.1186/s12868-019-0491-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421714PMC

Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy.

BMC Neurosci 2019 Mar 18;20(1):12. Epub 2019 Mar 18.

Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.

Background: Transcranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still unclear, and further investigation is needed. The present study proposes to use near-infrared spectroscopy (NIRS) to observe cerebral hemodynamic change caused by tFUS in a noninvasive manner. Read More

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http://dx.doi.org/10.1186/s12868-019-0493-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423784PMC

The short-term recovery of corticomotor responses in elbow flexors.

BMC Neurosci 2019 Mar 14;20(1). Epub 2019 Mar 14.

Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, Calgary, AB, T2N 1N4, Canada.

Background: The recovery of neurophysiological parameters at various time intervals following fatiguing exercise has been investigated previously. However, the repetition of neuromuscular assessments during the recovery period may have interfered with the true corticomotor excitability responses. In this experiment, fatiguing contractions were combined with a single post-fatigue assessment at varying time points. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-019-0492-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419454PMC
March 2019
8 Reads

Enhanced setup for wired continuous long-term EEG monitoring in juvenile and adult rats: application for epilepsy and other disorders.

BMC Neurosci 2019 Mar 4;20(1). Epub 2019 Mar 4.

Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Diana Tamari Sabbagh (DTS) Building, first floor, 117b, P.O. Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon.

Background: The electroencephalogram (EEG) is a widely used laboratory technique in rodent models of epilepsy, traumatic brain injury (TBI), and other neurological diseases accompanied by seizures. Obtaining prolonged continuous EEG tracings over weeks to months is essential to adequately answer research questions related to the chronobiology of seizure emergence, and to the effect of potential novel treatment strategies. Current EEG recording methods include wired and the more recent but very costly wireless technologies. Read More

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http://dx.doi.org/10.1186/s12868-019-0490-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398261PMC
March 2019
3 Reads

Exercise challenge alters Default Mode Network dynamics in Gulf War Illness.

BMC Neurosci 2019 Feb 21;20(1). Epub 2019 Feb 21.

Chronic Pain and Fatigue Research Center, Georgetown University Medical Center, Pre-Clinical Science Building, Rm LD3, 3800 Reservoir Road NW, Washington, DC, 20007, USA.

Background: Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War and has no known cause. Everyday symptoms include pain, fatigue, migraines, and dyscognition. A striking syndromic feature is post-exertional malaise (PEM). Read More

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http://dx.doi.org/10.1186/s12868-019-0488-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385399PMC
February 2019
1 Read

Astrocytes infected with Chlamydia pneumoniae demonstrate altered expression and activity of secretases involved in the generation of β-amyloid found in Alzheimer disease.

BMC Neurosci 2019 Feb 20;20(1). Epub 2019 Feb 20.

Department of Bio-Medical Sciences, Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA, 19131, USA.

Background: Epidemiologic studies strongly suggest that the pathophysiology of late-onset Alzheimer disease (AD) versus early-onset AD has environmental rather than genetic causes, thus revealing potentially novel therapeutic targets to limit disease progression. Several studies supporting the "pathogen hypothesis" of AD demonstrate a strong association between pathogens and the production of β-amyloid, the pathologic hallmark of AD. Although the mechanism of pathogen-induced neurodegeneration of AD remains unclear, astrocytes, a key player of the CNS innate immune response and producer/metabolizer of β-amyloid, have been implicated. Read More

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http://dx.doi.org/10.1186/s12868-019-0489-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383264PMC
February 2019
2 Reads

Time dependent degeneration of the nigrostriatal tract in mice with 6-OHDA lesioned medial forebrain bundle and the effect of activin A on L-Dopa induced dyskinesia.

BMC Neurosci 2019 Feb 13;20(1). Epub 2019 Feb 13.

Centre for Neuroscience and Regenerative Medicine, Faculty of Science, University of Technology Sydney, PO Box 123, Broadway, Sydney, NSW, 2007, Australia.

Background: Accurately assessing promising therapeutic interventions for human diseases depends, in part, on the reproducibility of preclinical disease models. With the development of transgenic mice, the rapid adaptation of a 6-OHDA mouse model of Parkinson's disease that was originally described for the use in rats has come with a lack of a comprehensive characterization of lesion progression. In this study we therefore first characterised the time course of neurodegeneration in the substantia nigra pars compacta and striatum over a 4 week period following 6-OHDA injection into the medial forebrain bundle of mice. Read More

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http://dx.doi.org/10.1186/s12868-019-0487-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374903PMC
February 2019

Correction to: Computing reward prediction errors and learning valence in the insect mushroom body.

BMC Neurosci 2019 01 17;20(1). Epub 2019 Jan 17.

School of Engineering and Informatics, University of Sussex, Brighton, UK.

Following the publication of the original article [1], it was highlighted that an old version of the text for abstract P252 was published, thereby causing the text to no longer correspond with Fig. 1. Read More

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http://dx.doi.org/10.1186/s12868-019-0486-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335675PMC
January 2019
2 Reads

Inhibitory effect of ultrasonic stimulation on the voltage-dependent potassium currents in rat hippocampal CA1 neurons.

BMC Neurosci 2019 Jan 5;20(1). Epub 2019 Jan 5.

State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, No. 8 Hongrong Road, Hongqiao District, Tianjin, 300132, China.

Background: Transcranial ultrasonic stimulation is a novel noninvasive tool for neuromodulation, and has high spatial resolution and deep penetration. Although it can increase excitation of neurons, its effects on neuron are poorly understood. This study was to evaluate effect of ultrasonic stimulation (US) on neurons in vitro. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0485-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321733PMC
January 2019
12 Reads

Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.

BMC Neurosci 2019 Jan 3;20(1). Epub 2019 Jan 3.

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomas, Miguel Hidalgo, 11340, Ciudad de México, Mexico.

Background: Peripheral diabetic neuropathy can be painful and its symptoms include hyperalgesia, allodynia and spontaneous pain. Hydrogen sulfide (HS) is involved in diabetes-induced hyperalgesia and allodynia. However, the molecular target through which HS induces hyperalgesia in diabetic animals is unclear. Read More

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http://dx.doi.org/10.1186/s12868-018-0483-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317195PMC
January 2019
5 Reads

The modulation effect of non-invasive brain stimulation on cognitive function in patients with mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials.

BMC Neurosci 2019 Jan 3;20(1). Epub 2019 Jan 3.

Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Background: To prevent and control dementia, many scholars have focused on the transition stage between normal ageing and dementia, mild cognitive impairment (MCI) which is a key interventional target for dementia. Studies have shown that non-invasive brain stimulation (NIBS) is beneficial to improve cognitive function of MCI patients. However, whether NIBS is conducive to the protection of cognitive ability in MCI patients remains unknown due to limited evidence. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0484-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317253PMC
January 2019
12 Reads

Rapamycin treatment increases hippocampal cell viability in an mTOR-independent manner during exposure to hypoxia mimetic, cobalt chloride.

BMC Neurosci 2018 Dec 29;19(1):82. Epub 2018 Dec 29.

Department of Pharmaceutical Sciences, Biomanufacturing Research Institute Biotechnology Enterprise (BRITE), North Carolina Central University, Durham, NC, USA.

Background: Cobalt chloride (CoCl) induces chemical hypoxia through activation of hypoxia-inducible factor-1 alpha (HIF-1α). Mammalian target of rapamycin (mTOR) is a multifaceted protein capable of regulating cell growth, angiogenesis, metabolism, proliferation, and survival. In this study, we tested the efficacy of a well-known mTOR inhibitor, rapamycin, in reducing oxidative damage and increasing cell viability in the mouse hippocampal cell line, HT22, during a CoCl-simulated hypoxic insult. Read More

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http://dx.doi.org/10.1186/s12868-018-0482-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310999PMC
December 2018
3 Reads

Thrombin contributes to the injury development and neurological deficit after acute subdural hemorrhage in rats only in collaboration with additional blood-derived factors.

BMC Neurosci 2018 Dec 27;19(1):81. Epub 2018 Dec 27.

Institute for Neurosurgical Pathophysiology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.

Background: Acute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated intracranial pressure. Thrombin is one of the potential harmful blood components. Read More

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http://dx.doi.org/10.1186/s12868-018-0481-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307215PMC
December 2018
2 Reads

Offline encoding impaired by epigenetic regulations of monoamines in the guided propagation model of autism.

BMC Neurosci 2018 Dec 17;19(1):80. Epub 2018 Dec 17.

LIMSI (Computer Sciences Laboratory for Mechanics and Engineering Sciences), CNRS, rue John Von Neumann, Campus Universitaire d'Orsay - Bâtiment 508, 91403, Orsay Cedex, France.

Background: Environmental factors can modify the expression of genes, including those involved in the metabolism of neurotransmitters. Accounting for a control role of monoamine neurotransmitters, the guided propagation (GP) memory model may contribute to investigate the consequences of neuromodulation impairments on development disorders such as autism. A prenatal transient excess of 'monoamine oxidase A' enzyme is assumed here to trigger persistent epigenetic regulations that would induce imbalanced metabolisms of synaptic monoamines. Read More

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http://dx.doi.org/10.1186/s12868-018-0477-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298000PMC
December 2018
1 Read

Altered Slc25 family gene expression as markers of mitochondrial dysfunction in brain regions under experimental mixed anxiety/depression-like disorder.

BMC Neurosci 2018 Dec 11;19(1):79. Epub 2018 Dec 11.

Laboratory of Neuropathology Modeling, The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.

Background: Development of anxiety- and depression-like states under chronic social defeat stress in mice has been shown by many experimental studies. In this article, the differentially expressed Slc25* family genes encoding mitochondrial carrier proteins were analyzed in the brain of depressive (defeated) mice versus aggressive mice winning in everyday social confrontations. The collected samples of brain regions were sequenced at JSC Genoanalytica ( http://genoanalytica. Read More

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http://dx.doi.org/10.1186/s12868-018-0480-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288882PMC
December 2018
1 Read

The effect of anesthetic dose on the motor response induced by low-intensity pulsed ultrasound stimulation.

BMC Neurosci 2018 Dec 3;19(1):78. Epub 2018 Dec 3.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.

Background: Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state of the mice. However, the quantitative relationship between motor response and anesthetic dose remains unclear. Read More

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http://dx.doi.org/10.1186/s12868-018-0476-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278113PMC
December 2018
2 Reads

PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration.

BMC Neurosci 2018 Nov 29;19(1):76. Epub 2018 Nov 29.

Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.

Background: Global cerebral ischemia triggers neurodegeneration in the hippocampal CA1 region, but the mechanism of neuronal death remains elusive. The epsilon isoform of protein kinase C (PKCε) has recently been identified as a master switch that controls the nucleocytoplasmic trafficking of ATF2 and the survival of melanoma cells. It is of interest to assess the role of PKCε-ATF2 signaling in neurodegeneration. Read More

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http://dx.doi.org/10.1186/s12868-018-0479-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267029PMC
November 2018
1 Read

Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation.

BMC Neurosci 2018 Nov 29;19(1):77. Epub 2018 Nov 29.

Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.

Background: The treatment of Parkinson's disease is often complicated by levodopa-induced dyskinesia (LID). Nicotinic acetylcholine receptor agonists can alleviate LID in animal models but may be less effective in conditions of severe dopaminergic denervation. While the mechanisms of LID remain incompletely understood, elevated corticostriatal levels of the brain-derived neurotrophic factor (BDNF) have been suggested to play a role. Read More

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http://dx.doi.org/10.1186/s12868-018-0478-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267795PMC
November 2018
3 Reads

Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla H-MRS study.

BMC Neurosci 2018 Nov 20;19(1):75. Epub 2018 Nov 20.

Department of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.

Background: Traumatic brain injury (TBI) is a complex condition and remains a prominent public and medical health issue in individuals of all ages. A rapid increase in extracellular glutamate occurs after TBI, leading to glutamate-induced excitotoxicity, which causes neuronal damage and further functional impairments. Although inhibition of glutamate carboxypeptidase II (GCP II) is considered a potential approach for reducing glutamate-induced excitotoxicity after TBI, further detailed evidence regarding its efficacy is required. Read More

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http://dx.doi.org/10.1186/s12868-018-0473-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245916PMC
November 2018
9 Reads

Biaryl scaffold-focused virtual screening for anti-aggregatory and neuroprotective effects in Alzheimer's disease.

BMC Neurosci 2018 Nov 13;19(1):74. Epub 2018 Nov 13.

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

Background: Alzheimer's disease (AD) is a primary cause of dementia in ageing population affecting more than 35 million people around the globe. It is a chronic neurodegenerative disease caused by defected folding and aggregation of amyloid beta (Aβ) protein. Aβ is formed by the cleavage of membrane embedded amyloid precursor protein (APP) by using enzyme 'transmembrane aspartyl protease, β-secretase'. Read More

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http://dx.doi.org/10.1186/s12868-018-0472-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234579PMC
November 2018
22 Reads
2.665 Impact Factor

Downregulation of calcium-dependent NMDA receptor desensitization by sodium-calcium exchangers: a role of membrane cholesterol.

BMC Neurosci 2018 Nov 12;19(1):73. Epub 2018 Nov 12.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Torez 44, Saint-Petersburg, Russia.

Background: The plasma membrane Na/Ca-exchanger (NCX) has recently been shown to regulate Ca-dependent N-methyl-D-aspartate receptor (NMDAR) desensitization, suggesting a tight interaction of NCXs and NMDARs in lipid nanoclasters or "rafts". To evaluate possible role of this interaction we studied effects of Li on NMDA-elicited whole-cell currents and Ca responses of rat cortical neurons in vitro before and after cholesterol extraction by methyl-β-cyclodextrin (MβCD).

Results: Substitution Li for Na in the external solution caused a concentration-dependent decrease of steady-state NMDAR currents from 440 ± 71 pA to 111 ± 29 pA in 140 mM Na and 140 mM Li, respectively. Read More

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http://dx.doi.org/10.1186/s12868-018-0475-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233507PMC
November 2018
1 Read

Abstracts of the 6th Meeting of the Neapolitan Brain Group.

Authors:

BMC Neurosci 2018 Nov 13;19(Suppl 3):67. Epub 2018 Nov 13.

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http://dx.doi.org/10.1186/s12868-018-0466-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233258PMC
November 2018
2 Reads

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats.

BMC Neurosci 2018 Nov 9;19(1):71. Epub 2018 Nov 9.

Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.

Background: Neurological disorders suggest that the excitotoxicity involves a drastic increase in intracellular Ca concentrations and the formation of reactive oxygen species. The presence of these free radicals may also affect the dopaminergic system. The aim of this work was to determine if riboflavin (B) and pyridoxine (B) provide protection to the brain against free radicals generated by 3-nitropropionic acid (3-NPA) by measuring the levels of dopamine (DA) and selected oxidative stress markers. Read More

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http://dx.doi.org/10.1186/s12868-018-0474-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230234PMC
November 2018
7 Reads

Glycine receptors expression in rat spinal cord and dorsal root ganglion in prostaglandin E2 intrathecal injection models.

BMC Neurosci 2018 Nov 9;19(1):72. Epub 2018 Nov 9.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. The GlyRα3 subunit has recently emerged as a key factor in inflammatory pain pathways in the spinal cord dorsal horn (DH). Our study is to identify the extent of location and cell types expressing different GlyR subunits in spinal cord and dorsal root ganglion (DRGs). Read More

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http://dx.doi.org/10.1186/s12868-018-0470-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230273PMC
November 2018
2 Reads

Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.

BMC Neurosci 2018 Nov 6;19(1):69. Epub 2018 Nov 6.

Department of Animal Behavior, Freie Universität Berlin, Takustraße 6, 14195, Berlin, Germany.

Background: FoxP transcription factors play crucial roles for the development and function of vertebrate brains. In humans the neurally expressed FOXPs, FOXP1, FOXP2, and FOXP4 are implicated in cognition, including language. Neural FoxP expression is specific to particular brain regions but FoxP1, FoxP2 and FoxP4 are not limited to a particular neuron or neurotransmitter type. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0469-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219247PMC
November 2018
14 Reads

PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.

BMC Neurosci 2018 Nov 6;19(1):70. Epub 2018 Nov 6.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Background: The proteasome system plays an important role in synaptic plasticity. Induction and maintenance of long term potentiation is directly dependent on selective targeting of proteins for proteasomal degradation. The 20S proteasome activator PA28αβ activates hydrolysis of small nonubiquitinated peptides and possesses protective functions upon oxidative stress and proteinopathy. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0468-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218978PMC
November 2018
5 Reads

The significance of anti-neuronal antibodies for acute psychiatric disorders: a retrospective case-controlled study.

BMC Neurosci 2018 Nov 3;19(1):68. Epub 2018 Nov 3.

Department of Mental Health, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Background: The clinical significance of anti-neuronal antibodies in patients with psychiatric disorders, but without encephalitis, remains unknown. In patients admitted to acute psychiatric inpatient care we aimed to identify clinical features distinguishing anti-neuronal antibody positive patients from matched controls.

Results: Patients who were serum-positive to N-methyl D-aspartate receptor (NMDAR) (n = 21), contactin-associated protein 2 (CASPR2) (n = 14) and/or glutamic acid decarboxylase 65 (GAD65) (n = 9) antibodies (cases) were age and sex matched (1:2) with serum-negative patients from the same cohort (controls). Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0471-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215671PMC
November 2018
6 Reads

27th Annual Computational Neuroscience Meeting (CNS*2018): Part One.

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BMC Neurosci 2018 10 29;19(Suppl 2):64. Epub 2018 Oct 29.

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http://dx.doi.org/10.1186/s12868-018-0452-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205781PMC
October 2018
2 Reads

27th Annual Computational Neuroscience Meeting (CNS*2018): Part Two.

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BMC Neurosci 2018 10 29;19(Suppl 2):65. Epub 2018 Oct 29.

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http://dx.doi.org/10.1186/s12868-018-0451-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205774PMC
October 2018
2 Reads

Transcranial direct current stimulation for the treatment of tinnitus: a review of clinical trials and mechanisms of action.

BMC Neurosci 2018 Oct 25;19(1):66. Epub 2018 Oct 25.

Biomedical Engineering Department, Polytechnic University of Pachuca, Zempoala, Mexico.

Background: Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous therapeutic outcomes for tinnitus. The present study aims to review the recent advances in applications of tDCS for tinnitus treatment. Read More

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http://dx.doi.org/10.1186/s12868-018-0467-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202858PMC
October 2018
18 Reads
2.665 Impact Factor

Functional EEG connectivity during competition.

BMC Neurosci 2018 Oct 18;19(1):63. Epub 2018 Oct 18.

Research Unit in Affective and Social Neuroscience, Catholic University of the Sacred Heart, Milan, Italy.

Background: Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since it stresses the relevance and salience of social comparison processes between the inter-agents that are involved in a common task. The majority of studies, however, investigated such kind of social interaction via one-person individual paradigms, thus not taking into account relevant information concerning interdependent participants' behavioral and neural responses. Read More

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http://dx.doi.org/10.1186/s12868-018-0464-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194561PMC
October 2018
16 Reads

Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis.

BMC Neurosci 2018 10 17;19(1):62. Epub 2018 Oct 17.

Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.

Efficient blood supply to the brain is of paramount importance to its normal functioning and improper blood flow can result in potentially devastating neurological consequences. Cerebral blood flow in response to neural activity is intrinsically regulated by a complex interplay between various cell types within the brain in a relationship termed neurovascular coupling. The breakdown of neurovascular coupling is evident across a wide variety of both neurological and psychiatric disorders including Alzheimer's disease. Read More

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http://dx.doi.org/10.1186/s12868-018-0465-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192291PMC
October 2018
15 Reads

Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes.

BMC Neurosci 2018 Oct 16;19(1):61. Epub 2018 Oct 16.

Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, #4655 University Road, University Science Park, Changqing District, Jinan, 250355, China.

Background: Epidemiological surveys and studies with animal models have established a relationship between maternal stress and affective disorders in their offspring. However, whether maternal depression before pregnancy influences behaviour and related neurobiological mechanisms in the offspring has not been studied.

Results: A social defeat stress (SDS) maternal rat model was established using the resident-intruder paradigm with female specific pathogen-free Wistar rats and evaluated with behavioural tests. Read More

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http://dx.doi.org/10.1186/s12868-018-0463-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192280PMC
October 2018
7 Reads

Effect of pulsed transcranial ultrasound stimulation at different number of tone-burst on cortico-muscular coupling.

BMC Neurosci 2018 Oct 3;19(1):60. Epub 2018 Oct 3.

Institute of Electric Engineering, Yanshan University, Qinhuangdao, 066004, Hebei, China.

Background: Pulsed transcranial ultrasound stimulation (pTUS) can modulate the neuronal activity of motor cortex and elicit muscle contractions. Cortico-muscular coupling (CMC) can serve as a tool to identify interaction between the oscillatory activity of the motor cortex and effector muscle. This research aims to explore the neuromodulatory effect of low-intensity, pTUS with different number of tone burst to neural circuit of motor-control system by analyzing the coupling relationship between motor cortex and tail muscle in mouse. Read More

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http://dx.doi.org/10.1186/s12868-018-0462-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169002PMC
October 2018
18 Reads
2.665 Impact Factor

An effort toward molecular biology of food deprivation induced food hoarding in gonadectomized NMRI mouse model: focus on neural oxidative status.

BMC Neurosci 2018 Sep 24;19(1):59. Epub 2018 Sep 24.

Department of Accounting, School of Economics and Accounting, Islamic Azad University South Tehran Branch, Tehran, Iran.

Background: Environmental uncertainty, such as food deprivation, may alter internal milieu of nervous system through various mechanisms. In combination with circumstances of stress or aging, high consumption of unsaturated fatty acids and oxygen can make neural tissues sensitive to oxidative stress (OS). For adult rats, diminished level of gonadal steroid hormones accelerates OS and may result in special behavioral manifestations. Read More

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http://dx.doi.org/10.1186/s12868-018-0461-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154416PMC
September 2018
4 Reads

Anti-inflammatory effects of minocycline are mediated by retinoid signaling.

BMC Neurosci 2018 Sep 21;19(1):58. Epub 2018 Sep 21.

Section Clinical Neurobiology, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité - University Medicine Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.

Background: Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data point towards retinoid-mediated effects of minocycline in murine brain and skin, and towards a vicious cycle of neuroinflammation which is driven by microglial activation-induced breakdown of local retinoids such as retinoic acid (RA). We therefore sought to study minocycline's anti-inflammatory effects on human microglial-like monocyte-derived cells in the context of retinoid signaling. Read More

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http://dx.doi.org/10.1186/s12868-018-0460-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151010PMC
September 2018
5 Reads

Transcranial focused ultrasound stimulation of motor cortical areas in freely-moving awake rats.

BMC Neurosci 2018 Sep 19;19(1):57. Epub 2018 Sep 19.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Background: Low-intensity transcranial focused ultrasound (tFUS) has emerged as a new non-invasive modality of brain stimulation with the potential for high spatial selectivity and penetration depth. Anesthesia is typically applied in animal-based tFUS brain stimulation models; however, the type and depth of anesthesia are known to introduce variability in responsiveness to the stimulation. Therefore, the ability to conduct sonication experiments on awake small animals, such as rats, is warranted to avoid confounding effects of anesthesia. Read More

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http://dx.doi.org/10.1186/s12868-018-0459-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146769PMC
September 2018
3 Reads

Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study.

BMC Neurosci 2018 Sep 14;19(1):56. Epub 2018 Sep 14.

Division of Physical Therapy and Division of Rehabilitation Science, Department of Rehabilitation Medicine, Medical School, University of Minnesota, 426 Church St. SE Rm 361, Minneapolis, MN, 55455, USA.

Background: Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI to extend these findings. We test the effect of tFUS on 7T BOLD fMRI signals from individual finger representations in the human primary motor cortex (M1) and connected cortical motor regions. Read More

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http://dx.doi.org/10.1186/s12868-018-0456-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137744PMC
September 2018
1 Read

Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs.

BMC Neurosci 2018 Sep 12;19(1):55. Epub 2018 Sep 12.

Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.

Background: The long-term effects of psychotropic drugs are associated with the reversal of disease-related alterations through the reorganization and normalization of neuronal connections. Molecular factors that trigger drug-induced brain plasticity remain only partly understood. Doublecortin-like kinase 1 (Dclk1) possesses microtubule-polymerizing activity during synaptic plasticity and neurogenesis. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0458-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134793PMC
September 2018
6 Reads

Single-trial dynamics explain magnitude sensitive decision making.

BMC Neurosci 2018 Sep 10;19(1):54. Epub 2018 Sep 10.

School of Psychological and Cognitive Sciences, Peking University, Beijing, 100871, China.

Background: Previous research has reported or predicted, on the basis of theoretical and computational work, magnitude sensitive reaction times. Magnitude sensitivity can arise (1) as a function of single-trial dynamics and/or (2) as recent computational work has suggested, while single-trial dynamics may be magnitude insensitive, magnitude sensitivity could arise as a function of overall reward received which in turn affects the speed at which decision boundaries collapse, allowing faster responses as the overall reward received increases.

Results: Here, we review previous theoretical and empirical results and we present new evidence for magnitude sensitivity arising as a function of single-trial dynamics. Read More

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http://dx.doi.org/10.1186/s12868-018-0457-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131863PMC
September 2018
1 Read

Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons.

BMC Neurosci 2018 Sep 6;19(1):52. Epub 2018 Sep 6.

The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650031, Yunnan, People's Republic of China.

Background: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1β (IL-1β), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. However, the mechanisms of how EPA regulates BDNF expression remains incompletely understood. The present study investigated the role of Akt/CREB signaling in the effect of EPA on BDNF expression and its neuroprotective effect. Read More

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http://dx.doi.org/10.1186/s12868-018-0455-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128001PMC
September 2018
4 Reads

The roles of aromatic residues in the glycine receptor transmembrane domain.

BMC Neurosci 2018 Sep 6;19(1):53. Epub 2018 Sep 6.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

Background: Cys-loop receptors play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular, transmembrane (TM) and intracellular domain. Each TM domain contains 4 α-helices (M1-M4) joined by loops of varying lengths. Read More

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http://dx.doi.org/10.1186/s12868-018-0454-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127993PMC
September 2018
14 Reads

Leptin: role over central nervous system in epilepsy.

BMC Neurosci 2018 09 5;19(1):51. Epub 2018 Sep 5.

Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Cra 24 No 63C-69, Bogotá, Colombia.

Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. Read More

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http://dx.doi.org/10.1186/s12868-018-0453-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126011PMC
September 2018
2 Reads

The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats.

BMC Neurosci 2018 08 13;19(1):49. Epub 2018 Aug 13.

Department of Biology, Rayan Center for Neuroscience and Behavior, Faculty of Science, Ferdowsi University of Mashhad, P.O. Box 9177948974, Mashhad, Iran.

Background: Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known experimental model for epileptic seizures. Read More

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http://dx.doi.org/10.1186/s12868-018-0445-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090721PMC
August 2018
3 Reads