138 results match your criteria BMC hematology[Journal]


Seroprevalence of transfusion transmitted infections among blood donors in Gash Barka Zonal Blood Transfusion Center, Barentu, Eritrea, 2014 through 2017.

BMC Hematol 2019 12;19. Epub 2019 Mar 12.

Department of Clinical Laboratory Science, Asmara College of Health Sciences, P.O. Box 8566, Asmara, Eritrea.

Background: Transfusion-transmissible infections pose a major health risk in developing countries, including Eritrea. In the present study, we sought to determine the prevalence of specific transfusion transmitted infections (TTIs) and the associated risk factors among blood donors at a newly established regional blood transfusion center in Barentu, Eritrea.

Methods: The seroprevalence of markers for specific TTIs by sex, age, educational status, residence, occupation, and donor type was evaluated for donors who donated blood between July 2014 and April 2017. Read More

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http://dx.doi.org/10.1186/s12878-019-0136-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417238PMC
March 2019
2 Reads

Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine.

BMC Hematol 2019 18;19. Epub 2019 Feb 18.

1Department of Medical Laboratory Sciences, Al-Quds University, East Jerusalem, Palestine.

Background: We aimed to investigate the molecular basis of β-Thalassemia intermedia (TI) in the West Bank region and its management practices.

Methods: This was a case series multi-center study and included 51 cases of TI. DNA sequencing was used to analyze β-globin gene mutations. Read More

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http://dx.doi.org/10.1186/s12878-019-0135-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380065PMC
February 2019
3 Reads

Magnitude of elevated iron stores and risk associated in steady state sickle cell anemia Congolese children: a cross sectional study.

BMC Hematol 2019 8;19. Epub 2019 Feb 8.

1Division of Nephrology, Nephrology Unit, Department of Internal Medicine, University Hospital of Kinshasa, Faculty of Medicine, University of Kinshasa, Kinshasa XI, PO.BOX 123, Democratic Republic of Congo.

Background: The serum ferritin assay is recommended in Sickle Cell Anemia (SCA) patients receiving regular transfusions. According to several authors, elevated iron stores indicating iron chelation corresponds to hyperferritinemia ≥500 ng/ml, and becomes detectable after twenty blood transfusions. The objectives of the study were to determine the prevalence of elevated iron stores and identify associated risk factors in a case series of Steady state SCA Congolese children. Read More

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http://dx.doi.org/10.1186/s12878-019-0134-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368684PMC
February 2019
3 Reads

Effect of iron deficiency anemia on HbA1c in diabetic patients at Tikur Anbessa specialized teaching hospital, Addis Ababa Ethiopia.

BMC Hematol 2019 9;19. Epub 2019 Jan 9.

1College of Medicine and Health Sciences Department of Medical Laboratory Sciences, Wolkite University, Wolkite, Ethiopia.

Background: Hemoglobin A1C (HbA1c) is the predominant hemoglobin found in HbA1 fractions. A1c assay is the recommended assay for diagnosing diabetes and any condition that changes red cell turnover such as Iron deficiency Anemia (IDA), will lead to spurious A1C results. Therefore, the present study was aimed at determining the effect of IDA on HbA1c in diabetic patients attending Black Lion Specialized Teaching Hospital, Addis Ababa, Ethiopia. Read More

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http://dx.doi.org/10.1186/s12878-018-0132-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327502PMC
January 2019
1 Read

Prevalence of anemia among adults at Hawassa University referral hospital, Southern Ethiopia.

BMC Hematol 2019 8;19. Epub 2019 Jan 8.

2School of Nursing and Midwifery, Hawassa University College of Medicine and Health Sciences, Hawassa, Ethiopia.

Introduction: Anemia is a public health problem in Ethiopia. In spite of the fact that anemia is a common health burden with much severe consequences, the prevalence of the different types of anemia and its severity have not yet been well documented in different parts of the country. The study aimed to assess the prevalence of different types of anemia, including severity and association with age and sex of study population. Read More

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http://dx.doi.org/10.1186/s12878-018-0133-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323856PMC
January 2019

The role of haematological indices in predicting early iron deficiency among pregnant women in an urban area of Sri Lanka.

BMC Hematol 2018 22;18:37. Epub 2018 Dec 22.

1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Early detection and treatment of iron deficiency during pregnancy is crucial for optimum pregnancy outcomes. Anaemia is a late indictor of iron deficiency measured as Hb < 11 g/dL, and is widely used as a proxy for iron deficiency. We aimed to evaluate the role of red cell indices as a screening tool for early detection of iron deficiency among pregnant women in an urban area of Sri Lanka. Read More

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http://dx.doi.org/10.1186/s12878-018-0131-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303966PMC
December 2018
2 Reads

Risk factors of metabolic syndrome among adult Sudanese sickle cell anemia patients.

BMC Hematol 2018 27;18:38. Epub 2018 Dec 27.

Department of Physiology, Faculty of Medicine, Alneelain University, P.O. Box: 11121, 12702 Khartoum, Sudan.

Background: Sickle cell disease is a hereditary disorder characterized by haematological anaemia. Several studies assumed that adult sickle patients might develop metabolic syndrome features as hyperglycaemia, hypertension and dyslipidaemia. The aim of this study was to evaluate the metabolic syndrome risk factors among adult Sudanese with sickle cell anemia in the steady state. Read More

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http://dx.doi.org/10.1186/s12878-018-0110-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307197PMC
December 2018
3 Reads

Motivational factors for blood donation, potential barriers, and knowledge about blood donation in first-time and repeat blood donors.

BMC Hematol 2018 20;18:36. Epub 2018 Dec 20.

2Educational Innovations in Science and Technology, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region Ghana.

Background: Blood transfusion is an essential component of the health care system of every country and patients who require blood transfusion service as part of the clinical management of their condition have the right to expect that sufficient and safe blood will be available to meet their needs. However, this is not always the case, especially in developing countries. To recruit and retain adequate regular voluntary non-remunerated blood donors the motivators and barriers of donors must be understood. Read More

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https://bmchematol.biomedcentral.com/articles/10.1186/s12878
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http://dx.doi.org/10.1186/s12878-018-0130-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302390PMC
December 2018
2 Reads

Infections in patients with aplastic Anemia in Chiang Mai University.

BMC Hematol 2018 4;18:35. Epub 2018 Dec 4.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200 Thailand.

Background: Infection is a major complication in aplastic anemia (AA) patients. Primary objectives of this study were to determine the prevalence of infections and to determine types of pathogens associated with infections in patients with AA. Secondary objectives were to evaluate overall survival after infections as well as risk factors of infections in patients with AA. Read More

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http://dx.doi.org/10.1186/s12878-018-0129-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280474PMC
December 2018
2 Reads

Recombinant activated factor VII (rFVIIa) in refractory haemorrhage for non-haemophiliacs: an eleven-year single-centre experience.

BMC Hematol 2018 23;18:34. Epub 2018 Nov 23.

1Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, PNG Malaysia.

Background: Massive bleeding is one of the commonest salvageable causes of death. The search for an ideal haemostatic agent during massive bleeding is still ongoing. One of the novel haemostatic medications is recombinant activated factor VII (rFVIIa). Read More

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http://dx.doi.org/10.1186/s12878-018-0126-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251212PMC
November 2018
14 Reads

A ten year review of the sickle cell program in Muhimbili National Hospital, Tanzania.

BMC Hematol 2018 14;18:33. Epub 2018 Nov 14.

1Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania.

Background: Africa has the highest burden of Sickle cell disease (SCD) but there are few large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania, with 11,000 SCD births annually, established the Muhimbili Sickle Cell program aiming to improve understanding of SCD in Africa. We report the profile of SCD seen in the first 10 years at Muhimbili National Hospital (MNH). Read More

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http://dx.doi.org/10.1186/s12878-018-0125-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236876PMC
November 2018
15 Reads

Prevalence of anemia and its associated factors in human immuno deficiency virus infected adult individuals in Ethiopia. A systematic review and meta-analysis.

BMC Hematol 2018 12;18:32. Epub 2018 Nov 12.

6Department of Health Informatics, University of Gondar, P.O. Box 196, Gondar, Ethiopia.

Background: Anemia is a common hematologic disorder among human Immunodeficiency virus (HIV) infected adult Individuals. However, there is no concrete scientific evidence established at national level in Ethiopia. Hence, this review gave special emphasis on Ethiopian HIV infected adult individuals to estimate pooled prevalence of anemia and its associated factors at national level. Read More

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http://dx.doi.org/10.1186/s12878-018-0127-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233542PMC
November 2018
23 Reads

Prevalence, types and determinants of anemia among pregnant women in Sudan: a systematic review and meta-analysis.

BMC Hematol 2018 8;18:31. Epub 2018 Nov 8.

3Scarborough General Hospital, Scarborough, YO12 6QL UK.

Background: Anemia during pregnancy is a public health problem especially in developing countries and it is associated with maternal and perinatal adverse outcomes. There is no meta-analysis on anemia during pregnancy in Sudan. The current systemic review and meta-analysis was conducted to assess the prevalence, types and determinant of anemia during pregnancy in Sudan. Read More

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http://dx.doi.org/10.1186/s12878-018-0124-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225563PMC
November 2018

Storage related haematological and biochemical changes in infected and sickle cell trait donor blood.

BMC Hematol 2018 6;18:30. Epub 2018 Nov 6.

1Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.

Background: In sub-Saharan Africa where sickle cell trait (SCT) and malaria is prevalent, significant proportions of blood donors may be affected by one or more of these abnormalities. The haemato-biochemical properties of SCT and asymptomatic malaria in donor blood have not been evaluated. This study evaluated the haemato-biochemical impact of SCT and asymptomatic malaria infections in citrate-phosphate-dextrose-adenine (CPDA-1) stored donor blood units. Read More

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https://bmchematol.biomedcentral.com/articles/10.1186/s12878
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http://dx.doi.org/10.1186/s12878-018-0128-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220467PMC
November 2018
27 Reads

Effect of iron-folic acid supplementation on change of hemoglobin among visceral Leishmaniasis patients in northwest Ethiopia: a retrospective follow up study.

BMC Hematol 2018 21;18:29. Epub 2018 Sep 21.

2Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: An individual with visceral Leishmaniasis (VL) commonly present with anemia and one of the VL treatment center in northwest Ethiopia has been recommended iron-folic acid supplementation to these patients. But there is no documented evidence whether iron-folic acid supplementation improves the hematological profile of patients. Therefore, the study aimed to assess change in hemoglobin (Hb) and its determinant factors among VL patients with and without iron-folic acid supplementation in northwest Ethiopia. Read More

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http://dx.doi.org/10.1186/s12878-018-0123-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151065PMC
September 2018
3 Reads

The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura.

BMC Hematol 2018 20;18:28. Epub 2018 Sep 20.

2Department of Gastroenterology, Aleppo University Hospital, Aleppo, Syria.

Background: Idiopathic (immune) thrombocytopenic purpura (ITP) is an acquired disorder characterized by autoantibodies against platelet membrane antigens. Several studies found an association between Helicobacter Pylori infection and the incidence of ITP. So far, It is still unclear whether eradication will increase platelet counts in adult ITP patients. Read More

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http://dx.doi.org/10.1186/s12878-018-0119-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148778PMC
September 2018
3 Reads

The clinical presentation, utilization, and outcome of individuals with sickle cell anaemia presenting to urban emergency department of a tertiary hospital in Tanzania.

BMC Hematol 2018 17;18:25. Epub 2018 Sep 17.

7Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: Sickle cell anaemia (SCA) is prevalent in sub-Saharan Africa, with high risk of complications requiring emergency care. There is limited information about presentation of patients with SCA to hospitals for emergency care. We describe the clinical presentation, resource utilization, and outcomes of SCA patients presenting to the emergency department (ED) at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania. Read More

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https://bmchematol.biomedcentral.com/articles/10.1186/s12878
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http://dx.doi.org/10.1186/s12878-018-0122-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142707PMC
September 2018
4 Reads

Biochemical and hematological changes among anemic and non-anemic pregnant women attending antenatal clinic at the Bolgatanga regional hospital, Ghana.

BMC Hematol 2018 17;18:27. Epub 2018 Sep 17.

5Department of Molecular Medicine, School of Medical Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: Anemia in pregnancy may not only be associated with maternal morbidity and mortality but can also be detrimental to the fetus. A definitive diagnosis of anemia is a pre-requisite to unravelling possible cause(s), to allow appropriate treatment intervention. It is hypothesised that measured hemoglobin (HGB), complemented by biochemical and other hematological parameters would enhance anemia diagnosis. Read More

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http://dx.doi.org/10.1186/s12878-018-0121-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142348PMC
September 2018
4 Reads

Diagnostic accuracy in field conditions of the sickle SCAN® rapid test for sickle cell disease among children and adults in two West African settings: the DREPATEST study.

BMC Hematol 2018 17;18:26. Epub 2018 Sep 17.

3Inserm UMR 1027, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps, Université Paul Sabatier Toulouse 3, Faculté de Médecine Purpan, 37 Allées Jules Guesde, 31073 Toulouse Cedex 7, France.

Background: Sickle cell disease (SCD) accounts for 5% of mortality in African children aged < 5 years. Improving the care management and quality of life of patients with SCD requires a reliable diagnosis in resource-limited settings. We assessed the diagnostic accuracy of the rapid Sickle SCAN® point-of-care (POC) test for SCD used in field conditions in two West-African countries. Read More

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http://dx.doi.org/10.1186/s12878-018-0120-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142627PMC
September 2018
3 Reads

Seroprevalence and trends of transfusion transmitted infections at Harar blood bank in Harari regional state, Eastern Ethiopia: eight years retrospective study.

BMC Hematol 2018 15;18:24. Epub 2018 Sep 15.

College of Health and Medical Sciences, Department of Medical Laboratory Sciences, Haramaya University, P.O. Box 235, Harar, Ethiopia.

Background: The use of unscreened blood exposes the patient to many transfusion transmitted infections including Hepatitis B Virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), and syphilis, among others. Thus, blood transfusion demands for meticulous pre-transfusion testing and screening. Trends of transfusion transmitted infections are important to take appropriate measures on blood bank services. Read More

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http://dx.doi.org/10.1186/s12878-018-0115-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139147PMC
September 2018
4 Reads

Albumin, copper, manganese and cobalt levels in children suffering from sickle cell anemia at Kasumbalesa, in Democratic Republic of Congo.

BMC Hematol 2018 6;18:23. Epub 2018 Sep 6.

Department of Research, High Institute of Techniques Medicales, Lubumbashi, Democratic Republic of Congo.

Background: Sickle Cell Anemia (SCA) is characterized by high levels of oxidative stress markers and low levels of antioxidant capacity. Antioxidant defence mechanisms against the harmful effects of ROS requires cellular and extracellular enzymes. These enzymes requires micronutrient for complete activity. Read More

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https://bmchematol.biomedcentral.com/articles/10.1186/s12878
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http://dx.doi.org/10.1186/s12878-018-0118-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127910PMC
September 2018
23 Reads

Evaluation and characterization of tumor lysis syndrome before and after chemotherapy among pediatric oncology patients in Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia.

BMC Hematol 2018 4;18:22. Epub 2018 Sep 4.

2Department of Medical Biochemistry, School of Medicine, College of Health sciences, Addis Ababa University, P. O. Box 9086, Addis Ababa, Ethiopia.

Background: Tumor lysis syndrome (TLS) is a life-threatening emergency disorder, caused by an abrupt release of intracellular metabolites after tumor cell death. It is characterized by a series of metabolic manifestations, especially hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. The aim of this study was to evaluate and characterize the incidence of tumor lysis syndrome among pediatric oncology patients before and after treatment. Read More

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http://dx.doi.org/10.1186/s12878-018-0117-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122136PMC
September 2018
2 Reads

A new adult AML case with an extremely complex karyotype, remission and relapse combined with high hyperdiploidy of a normal chromosome set in secondary AML.

BMC Hematol 2018 31;18:21. Epub 2018 Aug 31.

1Department of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission, Damascus, Syria.

Background: Chromosomal abnormalities are diagnostic and prognostic key factors in acute myeloid leukemia (AML) patients, as they play a central role for risk stratification algorithms. High hyperdiploidy (HH), a rare cytogenetic abnormality seen commonly in elder male AML patients, is normally categorized under AML with complex karyotype (CK). Accordingly, patients with HH generally are associated with low remission rates and a short overall survival. Read More

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http://dx.doi.org/10.1186/s12878-018-0114-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119272PMC
August 2018
1 Read

Useful clinical features and hematological parameters for the diagnosis of dengue infection in patients with acute febrile illness: a retrospective study.

BMC Hematol 2018 29;18:20. Epub 2018 Aug 29.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intravaroros road, A. Muang, Chiang Mai, 50200 Thailand.

Background: Dengue infection patients are presented with acute febrile illness. Clinical presentations may mimic other infections. The serology for definite diagnosis is costly and inaccessible in many hospitals. Read More

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http://dx.doi.org/10.1186/s12878-018-0116-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114047PMC
August 2018
2 Reads

Rapid access clinic for unexplained lymphadenopathy and suspected malignancy: prospective analysis of 1000 patients.

BMC Hematol 2018 14;18:19. Epub 2018 Aug 14.

1Department of Medicine, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT UK.

Background: In patients presenting with peripheral lymphadenopathy, it is critical to effectively identify those with underlying cancer who require urgent specialist care.

Methods: We analyzed a large dataset of 1000 consecutive patients with unexplained lymphadenopathy referred between 2001 and 2009 to the Royal Marsden Hospital (RMH) rapid access lymph node diagnostic clinic (LNDC).

Results: Cancer was diagnosed in 14% of patients. Read More

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https://bmchematol.biomedcentral.com/articles/10.1186/s12878
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http://dx.doi.org/10.1186/s12878-018-0109-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092787PMC
August 2018
7 Reads

Rare and unusual case of anti-factor XI antibodies in patient with plasma cell leukemia.

BMC Hematol 2018 10;18:18. Epub 2018 Aug 10.

1Laboratory of Hematology and Immunohematology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Background: The acquired inhibitors of coagulation have been observed in very rare cases of monoclonal gammopathies. We report a very rare case of anti-factor XI antibodies in patient with plasma cell leukemia (PCL).

Case Presentation: This is a 59-year-old male patient without pathological history, admitted to the nephrology department for management of renal insufficiency and anemia syndrome. Read More

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http://dx.doi.org/10.1186/s12878-018-0100-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086047PMC
August 2018
26 Reads

Identification of a novel mutation in the factor VIII gene causing severe haemophilia A.

BMC Hematol 2018 31;18:17. Epub 2018 Jul 31.

1Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

Background: Deficiency in coagulation factor VIII encoded by results in the X-linked recessive bleeding disorder haemophilia A (HEMA). Here we describe the identification of a novel variant in the factor VIII gene, , in an adult male patient with severe haemophilia A.

Case Presentation: The patient was diagnosed in early childhood and subsequently co-infected with Hepatitis C and HIV acquired during early blood transfusion for haemophilia in the 1980ies. Read More

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http://dx.doi.org/10.1186/s12878-018-0113-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069878PMC
July 2018
4 Reads

Demographic characteristics of blood and blood components transfusion recipients and pattern of blood utilization in a tertiary health institution in southern Nigeria.

BMC Hematol 2018 31;18:16. Epub 2018 Jul 31.

Haematology Unit, Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria.

Background: An insight into the utilization pattern helps in future planning of blood drive. This study was conducted to describe the demographic characteristics of the transfusion recipients and pattern of blood and blood product utilization in Nigeria.

Methods: Blood bank registers of University of Calabar Teaching Hospital (UCTH) Calabar were analysed for a 12 month period. Read More

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http://dx.doi.org/10.1186/s12878-018-0112-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069751PMC

Hematological profile of pregnant women at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

BMC Hematol 2018 9;18:15. Epub 2018 Jul 9.

3School of Medical Laboratory Science, College of Health science, Addis Ababa University, Addis Ababa, Ethiopia.

Background: In pregnancy, hematological changes occur in order to meet the demands of the developing fetus and placenta, with major alterations in blood volume. Abnormal hematological profile affects pregnancy and its outcome. This study aimed to assess hematological profiles of pregnant women at a tertiary care teaching hospital. Read More

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http://dx.doi.org/10.1186/s12878-018-0111-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038189PMC
July 2018
10 Reads

Anemia and associated factors among children aged 6-23 months in Damot Sore District, Wolaita Zone, South Ethiopia.

BMC Hematol 2018 3;18:14. Epub 2018 Jul 3.

2Institute of Health, Public Health Faculty, Population and Family Health Department, Nutrition Course Team, Jimma University, Jimma, Ethiopia.

Background: Anemia affects a significant part of the population in nearly every country in the globe. Iron requirements are greatest at ages 6-23 months when growth is extremely rapid and critically essential in critical times of life. Even though infants and toddlers are highly at risk, they are not considered as separate populations in the estimation of anemia. Read More

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https://bmchematol.biomedcentral.com/articles/10.1186/s12878
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http://dx.doi.org/10.1186/s12878-018-0108-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029164PMC
July 2018
23 Reads

Adapting medical guidelines to be patient-centered using a patient-driven process for individuals with sickle cell disease and their caregivers.

BMC Hematol 2018 8;18:12. Epub 2018 Jun 8.

5Department of Pediatrics, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN USA.

Background: Evidence-based guidelines for sickle cell disease (SCD) health maintenance and management have been developed for primary health care providers, but not for individuals with SCD. To improve the quality of care delivered to individuals with SCD and their caregivers, the main purposes of this study were to: (1) understand the desire for patient-centered guidelines among the SCD community; and (2) adapt guideline material to be patient-centered using community-engagement strategies involving health care providers, community -based organizations, and individuals with the disease.

Methods: From May-December 2016, a volunteer sample of 107 individuals with SCD and their caregivers gave feedback at community forums ( = 64) and community listening sessions ( = 43) about technology use for health information and desire for SCD-related guidelines. Read More

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http://dx.doi.org/10.1186/s12878-018-0106-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994026PMC
June 2018
20 Reads

Experimental folate deficiency in human subjects: what is the influence of vitamin C status on time taken to develop megaloblastic anaemia?

BMC Hematol 2018 19;18:13. Epub 2018 Jun 19.

Unit 10, Laurel Springs, 18 Doolan Street, Nambour, QLD 4560 Australia.

Background: In 1962 Victor Herbert developed megaloblastic anaemia four months after commencing a severely folate-deficient diet whereas, in his self-experiment 50 years later, this author took 19 months to fully deplete his liver folate store. This author proposed that his own larger initial liver folate store, due to his vegetarian diet and consumption of fortified foods, was the cause of the time difference.

Main Text: This author now proposes that Herbert was also likely to have been deficient in vitamin C, thus shortening the time taken to develop folate deficiency. Read More

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http://dx.doi.org/10.1186/s12878-018-0107-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007024PMC
June 2018
4 Reads

Hemostatic state augmented with platelet indices among Sudanese diabetic septic foot.

BMC Hematol 2018 11;18:11. Epub 2018 May 11.

Hematology department, Port Sudan Ahlia College, Port Sudan, Sudan.

Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Read More

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http://dx.doi.org/10.1186/s12878-018-0104-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948665PMC
May 2018
2 Reads

Blood factory: which stem cells?

BMC Hematol 2018 10;18:10. Epub 2018 May 10.

Department of Life Sciences, University of Roehampton, Whiteland College, London, SW15 4JD UK.

Blood transfusions are often essential for treatment of severe anaemia and pregnancy complications. The unavailability of blood is a medical concern, especially in developing countries. New sources of red blood cells (RBC) are under investigation. Read More

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http://dx.doi.org/10.1186/s12878-018-0105-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946469PMC

Prevalence of thrombocytopenia before and after initiation of HAART among HIV infected patients at black lion specialized hospital, Addis Ababa, Ethiopia: a cross sectional study.

BMC Hematol 2018 9;18. Epub 2018 May 9.

2Department of Medical Physiology, School of Medicine, College of Health Sciences, Addis Ababa University, Ethiopia, Addis Ababa, Ethiopia.

Background: Hematological abnormalities are common in HIV positive patients. Of these, thrombocytopenia is a known complication which has been associated with a variety of bleeding disorders. However, its magnitude and related factors have not been well-characterized in the era of highly active antiretroviral therapy (HAART) in Ethiopia. Read More

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http://dx.doi.org/10.1186/s12878-018-0103-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944097PMC
May 2018
8 Reads

Prevalence of cytopenias in both HAART and HAART naïve HIV infected adult patients in Ethiopia: a cross sectional study.

BMC Hematol 2018 5;18. Epub 2018 Apr 5.

3Department of Internal Medicine, Bahir Dar University, -79 Bahir Dar, Ethiopia.

Background: In individuals infected with HIV, hematological abnormalities are common and are associated with increased risk of disease progression and death. However, the profile of hematological abnormalities in HIV infected adult patients is not known in Ethiopia. Thus, the aim of this study was to assess the hematological manifestations of HIV infection and to identify the factors associated with cytopenias in both HAART and HAART naïve HIV infected adult patients in Ethiopia. Read More

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http://dx.doi.org/10.1186/s12878-018-0102-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887186PMC
April 2018
16 Reads

Prevalence of anemia before and after initiation of antiretroviral therapy among HIV infected patients at Black Lion Specialized Hospital, Addis Ababa, Ethiopia: a cross sectional study.

BMC Hematol 2018 15;18. Epub 2018 Mar 15.

2Department of Medical Physiology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Anemia is the most common hematological abnormality in Human immunodeficiency virus (HIV) positive patients and a significant predictor of its progression to AIDS or death. This study was aimed to assess the prevalence of anemia before and after initiation of antiretroviral therapy (ART) among HIV positive patients attending Black Lion Specialized Hospital, Addis Ababa, Ethiopia.

Methods: A cross sectional study was conducted from January to April, 2017 in Black Lion Specialized Hospital, Addis Ababa, Ethiopia. Read More

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http://dx.doi.org/10.1186/s12878-018-0099-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856395PMC
March 2018
6 Reads

A pilot study on the usefulness of peripheral blood flow cytometry for the diagnosis of lower risk myelodysplastic syndromes: the "MDS thermometer".

BMC Hematol 2018 13;18. Epub 2018 Mar 13.

1Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal.

Background: Immunophenotypic analysis of the bone marrow (BM) cells has proven to be helpful in the diagnosis of Myelodysplastic Syndromes (MDS). However, the usefulness of flow cytometry (FCM) for the detection of myelodysplasia in the peripheral blood (PB) still needs to be investigated. The aim of this pilot study was to evaluate the value of FCM-based PB neutrophil and monocyte immunophenotyping for the diagnosis of lower risk MDS (LR-MDS). Read More

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http://dx.doi.org/10.1186/s12878-018-0101-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850915PMC
March 2018
5 Reads

A rare case of avascular necrosis in sickle cell trait: a case report.

BMC Hematol 2018 22;18. Epub 2018 Feb 22.

Georgia Campus-Philadelphia College of Osteopathic Medicine (GA-PCOM), Suwanee, GA 30024 USA.

Background: Sickle cell trait is usually an asymptomatic presentation of a patient with slightly different hemoglobin molecule makeup than normal. It is similar to a more serious disease, sickle cell disease, in which a person's hemoglobin is mutated in such a way that causes their red blood cells to easily change shape in certain environmental and internal states; this causes red blood cells to adhere to the walls and occlude the lumen of the arteries in which they travel, leading to downstream effects secondary to ischemia. Sickle cell trait does not have these ischemic effects, usually. Read More

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http://dx.doi.org/10.1186/s12878-018-0098-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824459PMC
February 2018
3 Reads

More is less, less is more, or does it really matter? The curious case of impact of azacitidine administration schedules on outcomes in patients with myelodysplastic syndromes.

BMC Hematol 2018 1;18. Epub 2018 Feb 1.

1Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT USA.

Myelodysplastic syndromes (MDS) encompass a diverse group of hematologic disorders characterized by ineffective and malignant hematopoiesis, peripheral cytopenias and significantly increased risk of progression to acute myeloid leukemia (AML). The hypomethylating agents (HMA) azacitidine and decitabine induce meaningful clinical responses in a significant subset of patients with MDS. Though never compared directly with decitabine, only azacitidine has improved overall survival (OS) compared to conventional care in a randomized trial in patients with higher-risk MDS. Read More

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http://dx.doi.org/10.1186/s12878-018-0095-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796398PMC
February 2018
6 Reads

Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia.

BMC Hematol 2018 31;18. Epub 2018 Jan 31.

2Department of Medicine, Division of Hematology, Western University, London, ON Canada.

Background: 5-Azacitidine administered as a 7-day dosing regimen (7-0-0) is approved in high risk IPSS myelodysplastic syndrome (MDS) patients. Alternative regimens such as a 5-day (5-0-0) or 7-day with a weekend break (5-2-2) are commonly used. No randomized controlled trial has been done directly comparing all three dosing regimens. Read More

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http://dx.doi.org/10.1186/s12878-017-0094-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793426PMC
January 2018
1 Read

Pregnant mothers are more anemic than lactating mothers, a comparative cross-sectional study, Bahir Dar, Ethiopia.

BMC Hematol 2018 16;18. Epub 2018 Jan 16.

Departement of pediatrics, saint paulose hospital, Addis Ababa, Ethiopia.

Background: Information on the hemoglobin status of pregnant and lactating mothers was scarce. The objectives of this study were to determine the burden and determinants of anemia in the pregnant and lactating mother.

Methods: A comparative cross-sectional study was conducted. Read More

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http://dx.doi.org/10.1186/s12878-018-0096-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771125PMC
January 2018
8 Reads

Factor V Leiden G1691A and prothrombin G20210A mutations among Palestinian patients with sickle cell disease.

BMC Hematol 2018 16;18. Epub 2018 Jan 16.

2Department of Medical Laboratory Sciences, Faculty of Health professions, Al-Quds University, Jerusalem, Palestine.

Background: Vascular thrombosis is an important pathophysiological aspect of sickle cell disease (SCD). This study aimed to investigate the prevalence and clinical impact of factor V Leiden G1691A (FVL) and prothrombin G20210A mutations among Palestinian sickle cell disease (SCD) patients.

Methods: A total of 117 SCD patients, including 59 patients with sickle cell anemia (SS), 33 patients with sickle β-thalassemia and 25 individuals with sickle cell trait (AS) were studied. Read More

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http://dx.doi.org/10.1186/s12878-018-0097-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771009PMC
January 2018
3 Reads

A novel fibrinogen mutation: g. 3057 C > T (p. Arg104 > Cys) impairs fibrinogen secretion.

BMC Hematol 2017 22;17:22. Epub 2017 Dec 22.

Molecular Pathology Laboratory, University of Otago, Christchurch, New Zealand.

Background: Abnormal fibrinogens can be caused by clinically silent hereditary mutations. A new case was detected accidentally in an 11-year-old girl when routine pre-operative coagulation tests were performed for nasal turbinate surgery.

Methods: The fibrinogen genes FGA, FGG and FGB were sequenced using standard protocols. Read More

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http://dx.doi.org/10.1186/s12878-017-0086-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741905PMC
December 2017
1 Read

A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia.

BMC Hematol 2017 28;17:21. Epub 2017 Nov 28.

Department of Hematology & Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Hypertension is a major health problem worldwide. It can lead to cardiovascular disease and also leads to functional disturbances including hematological parameters. The abnormalities of haematological parameters may enhance an end-organ damage. Read More

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http://dx.doi.org/10.1186/s12878-017-0093-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704458PMC
November 2017
11 Reads

Knowledge, attitude and practice of students towards blood donation in Arsi university and Adama science and technology university: a comparative cross sectional study.

BMC Hematol 2017 21;17:20. Epub 2017 Nov 21.

Department of Social and Population Health, Adama General Hospital and Medical College, Adama, Ethiopia.

Background: Blood can save millions of lives. Even though people do not donate blood regularly, there is a constant effort to balance the supply and demand of blood. The aim of this study was, therefore, to determine the knowledge, attitude and practice of blood donation between university students. Read More

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http://dx.doi.org/10.1186/s12878-017-0092-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697394PMC
November 2017
2 Reads

Emergency blood transfusion practices among anaemic children presenting to an urban emergency department of a tertiary hospital in Tanzania.

BMC Hematol 2017 10;17:19. Epub 2017 Nov 10.

Emergency Medicine Department Muhimbili University of Health and Allied Sciences, P.O Box 65001, Dar es Salaam, Tanzania.

Background: Severe anaemia contributes significantly to mortality, especially in children under 5 years of age. Timely blood transfusion is known to improve outcomes. We investigated the magnitude of anaemia and emergency blood transfusion practices amongst children under 5 years presenting to the Emergency Department (ED) of Muhimbili National Hospital (MNH) in Tanzania. Read More

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http://dx.doi.org/10.1186/s12878-017-0091-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681767PMC
November 2017
1 Read

Coagulation profile of Sudanese children with homozygous sickle cell disease and the effect of treatment with omega-3 fatty acid on the coagulation parameters.

BMC Hematol 2017 9;17:18. Epub 2017 Nov 9.

Department of Medical Biochemistry, Faculty of Medicine, University of Khartoum, Alghasr Street, Khartoum, Sudan.

Background: It has been reported that patients with SCD do have an abnormal coagulation profile. Coagulopathy is thought to be one of the key factors that contribute to the vaso-occlusive crisis that characterises sickle cell disease (SCD). In this study, we investigated whether Sudanese sickle cell patients have an abnormal coagulation profile. Read More

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http://dx.doi.org/10.1186/s12878-017-0089-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679360PMC
November 2017

Prevalence and determinants of anemia among pregnant women in Ethiopia; a systematic review and meta-analysis.

BMC Hematol 2017 17;17:17. Epub 2017 Oct 17.

School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, P.O.Box 79, Bahir Dar, Ethiopia.

Background: Anemia during pregnancy is one of the most common indirect obstetric cause of maternal mortality in developing countries. It is responsible for poor maternal and fetal outcomes. A limited number of studies were conducted on anemia during pregnancy in Ethiopia, and they present inconsistent findings. Read More

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http://dx.doi.org/10.1186/s12878-017-0090-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646153PMC
October 2017
13 Reads

Significantly elevated foetal haemoglobin levels in individuals with glucose 6-phosphate dehydrogenase disease and/or sickle cell trait: a cross-sectional study in Cape Coast, Ghana.

BMC Hematol 2017 25;17:16. Epub 2017 Sep 25.

Medical Laboratory Technology Department, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.

Background: Previously published data have demonstrated that sickle red blood cells produce twice as much reactive oxygen species (ROS) suggesting that co-inheritance of sickle cell disease (SCD) and glucose 6-phosphate dehydrogenase (G6PD) enzymopathy could lead to more severe anaemia during sickling crises. Elevated foetal haemoglobin (Hb F) levels have been shown to have positive modulatory effects on sickling crises and disease outcomes. This study sought to assess how inheritance of G6PD enzymopathy affects the level of Hb F and haemoglobin concentration in adults in steady state. Read More

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http://dx.doi.org/10.1186/s12878-017-0088-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613503PMC
September 2017
1 Read