961 results match your criteria BMC developmental biology[Journal]


Notch signaling in mouse blastocyst development and hatching.

BMC Dev Biol 2020 Jun 2;20(1). Epub 2020 Jun 2.

Reproduction and Development Laboratory, CIISA - Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477, Lisbon, Portugal.

Background: Mammalian early embryo development requires a well-orchestrated interplay of cell signaling pathways. Notch is a major regulatory pathway involved in cell-fate determination in embryonic and adult scenarios. However, the role of Notch in embryonic pre-implantation development is controversial. Read More

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http://dx.doi.org/10.1186/s12861-020-00216-2DOI Listing

Ephrin-B2 paces neuronal production in the developing neocortex.

BMC Dev Biol 2020 May 13;20(1):12. Epub 2020 May 13.

Centre de Biologie Intégrative (CBI), Centre de Biologie du Développement (CBD), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062, Toulouse, France.

Background: During mammalian cerebral cortex development, different types of projection neurons are produced in a precise temporal order and in stereotypical numbers. The mechanisms regulating timely generation of neocortex projection neurons and ensuring production in sufficient numbers of each neuronal identity are only partially understood.

Results: Here, we show that ephrin-B2, a member of the Eph:ephrin cell-to-cell communication pathway, sets the neurogenic tempo in the neocortex. Read More

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http://dx.doi.org/10.1186/s12861-020-00215-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222552PMC

High expressions of the cytoglobin and PGC-1α genes during the tissue regeneration of house gecko (Hemidactylus platyurus) tails.

BMC Dev Biol 2020 May 11;20(1):11. Epub 2020 May 11.

Center of Hypoxia and Oxidative Stress Studies (CHOSS), Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia Jl, Salemba Raya no. 6 Jl, Jakarta Pusat, Indonesia.

Background: The tissue regeneration process requires high oxygen and energy levels. Cytoglobin (Cygb) is a member of the globin family, which has the ability to bind oxygen, plays a role in dealing with oxidative stress, and carries oxygen into the mitochondria. Energy production for tissue regeneration is associated with mitochondria-especially mitochondrial biogenesis. Read More

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http://dx.doi.org/10.1186/s12861-020-00214-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216616PMC

The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits.

BMC Dev Biol 2020 Apr 22;20(1). Epub 2020 Apr 22.

College of Animal Science and Technology, Shandong Agricultural University, Tai'an, 271018, People's Republic of China.

Background: Hair follicles are an appendage of the vertebrate epithelium in the skin that arise from the embryonic ectoderm and regenerate cyclically during adulthood. Dermal papilla cells (DPCs) are the key dermal component of the hair follicle that directly regulate hair follicle development, growth and regeneration. According to recent studies, miRNAs play an important role in regulating hair follicle morphogenesis and the proliferation, differentiation and apoptosis of hair follicle stem cells. Read More

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http://dx.doi.org/10.1186/s12861-020-00213-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178635PMC

A practical staging atlas to study embryonic development of Octopus vulgaris under controlled laboratory conditions.

BMC Dev Biol 2020 Apr 16;20(1). Epub 2020 Apr 16.

Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven, Leuven, Belgium.

Background: Octopus vulgaris has been an iconic cephalopod species for neurobiology research as well as for cephalopod aquaculture. It is one of the most intelligent and well-studied invertebrates, possessing both long- and short-term memory and the striking ability to perform complex cognitive tasks. Nevertheless, how the common octopus developed these uncommon features remains enigmatic. Read More

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http://dx.doi.org/10.1186/s12861-020-00212-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164171PMC

Butterfly eyespot color pattern formation requires physical contact of the pupal wing epithelium with extracellular materials for morphogenic signal propagation.

Authors:
Joji M Otaki

BMC Dev Biol 2020 Mar 31;20(1). Epub 2020 Mar 31.

The BCPH Unit of Molecular Physiology, Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Okinawa, 903-0213, Japan.

Background: Eyespot color pattern formation on butterfly wings is sensitive to physical damage and physical distortion as well as physical contact with materials on the surface of wing epithelial tissue at the pupal stage. Contact-mediated eyespot color pattern changes may imply a developmental role of the extracellular matrix in morphogenic signal propagation. Here, we examined eyespot responses to various contact materials, focusing on the hindwing posterior eyespots of the blue pansy butterfly, Junonia orithya. Read More

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http://dx.doi.org/10.1186/s12861-020-00211-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110832PMC

Bioelectrical and cytoskeletal patterns correlate with altered axial polarity in the follicular epithelium of the Drosophila mutant gurken.

BMC Dev Biol 2020 03 13;20(1). Epub 2020 Mar 13.

RWTH Aachen University, Institut für Biologie II, Abt. Zoologie und Humanbiologie, Worringerweg 3, 52056, Aachen, Germany.

Background: Bioelectrical signals are known to be involved in the generation of cell and tissue polarity as well as in cytoskeletal dynamics. The epithelium of Drosophila ovarian follicles is a suitable model system for studying connections between electrochemical gradients, patterns of cytoskeletal elements and axial polarity. By interactions between soma and germline cells, the transforming growth factor-α homolog Gurken (Grk) establishes both the anteroposterior and the dorsoventral axis during oogenesis. Read More

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http://dx.doi.org/10.1186/s12861-020-00210-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071586PMC

Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids.

BMC Dev Biol 2020 02 26;20(1). Epub 2020 Feb 26.

The Wellcome Trust/ Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.

Background: Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously reported human pancreas organoid (hPO) cultures do not expand efficiently long-term in a chemically defined, serum-free medium. We sought to generate a 3D culture system for long-term expansion of human pancreas ductal cells as hPOs to serve as the basis for studies of human pancreas ductal epithelium, exocrine pancreatic diseases and the development of a genomically stable replacement cell therapy for diabetes mellitus. Read More

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http://dx.doi.org/10.1186/s12861-020-0209-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043048PMC
February 2020

Keratin 86 is up-regulated in the uterus during implantation, induced by oestradiol.

BMC Dev Biol 2020 02 7;20(1). Epub 2020 Feb 7.

College of Basic Medical Sciences, Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian, 116044, Liaoning, China.

Background: Uterine receptivity is one of the determinants of embryo implantation, which is responsible for pregnancy success. Aberrant embryo implantation due to disrupted uterine receptivity is usually found in ovarian hyperstimulation induced hyperoestrogen patients.

Results: This study identified keratin 86 (KRT86), a fibrous structural protein, which was upregulated in uterine endometrium during peri-implantation. Read More

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http://dx.doi.org/10.1186/s12861-020-0208-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006210PMC
February 2020
2.667 Impact Factor

Downregulation of lncRNA DANCR promotes osteogenic differentiation of periodontal ligament stem cells.

BMC Dev Biol 2020 01 14;20(1). Epub 2020 Jan 14.

Department of Stomatology, Shanghai East Hospital Affiliated to Tongji University, No.150 Jimo Rd., Shanghai, 200120, China.

Background: Long non-coding RNAs (lncRNAs) have been widely known to have an appreciable effect in physiology and pathology. In tooth regeneration, periodontal ligament stem cells (PDLSCs) are regarded as a key effector, whereas, how lncRNA acts in the osteogenic differentiation of PDLSCs have not been completely understood. This study aims to find out the relationship between lncRNA DANCR and the proliferation and osteogenic differentiation of PDLSCs. Read More

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http://dx.doi.org/10.1186/s12861-019-0206-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958786PMC
January 2020

Spontaneous embryo resorption in the mouse is triggered by embryonic apoptosis followed by rapid removal via maternal sterile purulent inflammation.

BMC Dev Biol 2020 01 9;20(1). Epub 2020 Jan 9.

Institute of Anatomy, Prof. em., University of Tubingen, Tubingen, Germany.

Background: In normal mammalian development a high percentage of implantations is lost by spontaneous resorption. This is a major problem in assisted reproduction and blastocyst transfer. Which embryo will be resorbed is unpredictable. Read More

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http://dx.doi.org/10.1186/s12861-019-0201-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953269PMC
January 2020

Expression analysis of Rab11 during zebrafish embryonic development.

BMC Dev Biol 2019 12 30;19(1):25. Epub 2019 Dec 30.

College of life science, Nantong University, 9# Seyuan Road, Nantong, 226001, China.

Background: Rab proteins are GTPases responsible for intracellular vesicular trafficking regulation. Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development. In zebrafish, there are 3 rab11 paralogues, known as rab11a, rab11ba and rab11bb, sharing high identity with each other. Read More

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http://dx.doi.org/10.1186/s12861-019-0207-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936149PMC
December 2019

Comparison of the transcriptomes of two tardigrades with different hatching coordination.

BMC Dev Biol 2019 12 9;19(1):24. Epub 2019 Dec 9.

Institute for Advanced Biosciences, Keio University, Mizukami 246-2, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan.

Background: Tardigrades are microscopic organisms, famous for their tolerance against extreme environments. The establishment of rearing systems of multiple species has allowed for comparison of tardigrade physiology, in particular in embryogenesis. Interestingly, in-lab cultures of limnic species showed smaller variation in hatching timing than terrestrial species, suggesting a hatching regulation mechanism acquired by adaptation to their habitat. Read More

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http://dx.doi.org/10.1186/s12861-019-0205-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925440PMC
December 2019

DNA methylation and miRNA-1296 act in concert to mediate spatiotemporal expression of KPNA7 during bovine oocyte and early embryonic development.

BMC Dev Biol 2019 12 2;19(1):23. Epub 2019 Dec 2.

Laboratory of Animal Biotechnology and Genomics, Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV, 26506, USA.

Background: Epigenetic regulation of oocyte-specific maternal factors is essential for oocyte and early embryonic development. KPNA7 is an oocyte-specific maternal factor, which controls transportation of nuclear proteins important for early embryonic development. To elucidate the epigenetic mechanisms involved in the controlled expression of KPNA7, both DNA methylation associated transcriptional silencing and microRNA (miRNA)-mediated mRNA degradation of KPNA7 were examined. Read More

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http://dx.doi.org/10.1186/s12861-019-0204-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886206PMC
December 2019

Survival of Polyploid hybrid salamander embryos.

BMC Dev Biol 2019 11 12;19(1):21. Epub 2019 Nov 12.

Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA.

Background: Animals with polyploid, hybrid nuclei offer a challenge for models of gene expression and regulation during embryogenesis. To understand how such organisms proceed through development, we examined the timing and prevalence of mortality among embryos of unisexual salamanders in the genus Ambystoma.

Results: Our regional field surveys suggested that heightened rates of embryo mortality among unisexual salamanders begin in the earliest stages of embryogenesis. Read More

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http://dx.doi.org/10.1186/s12861-019-0202-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849221PMC
November 2019

Electrochemical gradients are involved in regulating cytoskeletal patterns during epithelial morphogenesis in the Drosophila ovary.

BMC Dev Biol 2019 11 12;19(1):22. Epub 2019 Nov 12.

Institut für Biologie II, Abt. Zoologie und Humanbiologie, RWTH Aachen University, Worringerweg 3, 52056, Aachen, Germany.

Background: During Drosophila oogenesis, the follicular epithelium differentiates into several morphologically distinct follicle-cell populations. Characteristic bioelectrical properties make this tissue a suitable model system for studying connections between electrochemical signals and the organisation of the cytoskeleton. Recently, we have described stage-specific transcellular antero-posterior and dorso-ventral gradients of intracellular pH (pH) and membrane potential (V) depending on the asymmetrical distribution and/or activity of various ion-transport mechanisms. Read More

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http://dx.doi.org/10.1186/s12861-019-0203-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852995PMC
November 2019

YWHA (14-3-3) protein isoforms and their interactions with CDC25B phosphatase in mouse oogenesis and oocyte maturation.

BMC Dev Biol 2019 10 22;19(1):20. Epub 2019 Oct 22.

Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA.

Background: Immature mammalian oocytes are held arrested at prophase I of meiosis by an inhibitory phosphorylation of cyclin-dependent kinase 1 (CDK1). Release from this meiotic arrest and germinal vesicle breakdown is dependent on dephosphorylation of CDK1 by the protein, cell cycle division 25B (CDC25B). Evidence suggests that phosphorylated CDC25B is bound to YWHA (14-3-3) proteins in the cytoplasm of immature oocytes and is thus maintained in an inactive form. Read More

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http://dx.doi.org/10.1186/s12861-019-0200-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805688PMC
October 2019

A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice.

BMC Dev Biol 2019 10 7;19(1):19. Epub 2019 Oct 7.

Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, 10461, USA.

Background: Mouse NOTCH1 carries a highly conserved O-fucose glycan at Thr466 in epidermal growth factor-like repeat 12 (EGF12) of the extracellular domain. O-Fucose at this site has been shown by X-ray crystallography to be recognized by both DLL4 and JAG1 Notch ligands. We previously showed that a Notch1 Thr466Ala mutant exhibits very little ligand-induced NOTCH1 signaling in a reporter assay, whereas a Thr466Ser mutation enables the transfer of O-fucose and reverts the NOTCH1 signaling defect. Read More

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http://dx.doi.org/10.1186/s12861-019-0199-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781419PMC
October 2019
1 Read

Sonic hedgehog promotes chondrogenesis of rabbit bone marrow stem cells in a rotary cell culture system.

BMC Dev Biol 2019 08 12;19(1):18. Epub 2019 Aug 12.

Department of Orthopaedics, Tenth People's Hospital of Tongji University, Tongji University, Shanghai, 200072, China.

Background: Sonic hedgehog (Shh) is an important signalling protein involved in the induction of early cartilaginous differentiation. Herein, we demonstrate that Shh markedly induces chondrogenesis of rabbit bone marrow stromal cells (BMSCs) under microgravity conditions, and promotes cartilage regeneration.

Results: In the rotary cell culture system (RCCS), chondrogenic differentiation was revealed by stronger Toluidine Blue and collagen II immunohistochemical staining in the Shh transfection group, and chondroinductive activity of Shh was equivalent to that of TGF-β. Read More

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http://dx.doi.org/10.1186/s12861-019-0198-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689882PMC
August 2019
2 Reads
2.667 Impact Factor

Role of PRY-1/Axin in heterochronic miRNA-mediated seam cell development.

BMC Dev Biol 2019 07 15;19(1):17. Epub 2019 Jul 15.

Department of Biology, McMaster University, ON L8S-4K1, Hamilton, Canada.

Background: Caenorhabditis elegans seam cells serve as a good model to understand how genes and signaling pathways interact to control asymmetric cell fates. The stage-specific pattern of seam cell division is coordinated by a genetic network that includes WNT asymmetry pathway components WRM-1, LIT-1, and POP-1, as well as heterochronic microRNAs (miRNAs) and their downstream targets. Mutations in pry-1, a negative regulator of WNT signaling that belongs to the Axin family, were shown to cause seam cell defects; however, the mechanism of PRY-1 action and its interactions with miRNAs remain unclear. Read More

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http://dx.doi.org/10.1186/s12861-019-0197-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631683PMC

Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression.

BMC Dev Biol 2019 07 8;19(1):16. Epub 2019 Jul 8.

Blood Research Institute, Versiti, 8733 West Watertown Plank Road, Milwaukee, WI, 53226, USA.

Background: The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role during early mammalian development and pluripotency. While multiple groups have generated knockouts combining loss of different Tet proteins in murine embryonic stem cells (ESCs), differences in genetic background and approaches has made it difficult to directly compare results and discern the direct mechanism by which Tet proteins regulate the transcriptome. To address this concern, we utilized genomic editing in an isogenic pluripotent background which permitted a quantitative, flow-cytometry based measurement of pluripotency in combination with genome-wide assessment of gene expression and DNA methylation changes. Read More

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http://dx.doi.org/10.1186/s12861-019-0196-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615237PMC

Insulin signaling mediates previtellogenic development and enhances juvenile hormone-mediated vitellogenesis in a lepidopteran insect, Maruca vitrata.

BMC Dev Biol 2019 07 5;19(1):14. Epub 2019 Jul 5.

Department of Plant Medicals, Andong National University, Andong, 36729, Korea.

Background: Insulin/insulin-like growth peptide signaling (IIS) down-regulates hemolymph sugar level and facilitates larval growth in the soybean pod borer, Maruca vitrata. The objective of this study is to determine whether IIS of M. vitrata can mediate ovarian development of adult females. Read More

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http://dx.doi.org/10.1186/s12861-019-0194-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610926PMC
July 2019
2 Reads

Importance of prostate androgen-regulated mucin-like protein 1 in development of the bovine blastocyst.

BMC Dev Biol 2019 07 5;19(1):15. Epub 2019 Jul 5.

Department of Animal Sciences, D.H. Barron Reproductive and Perinatal Biology Research Program and Genetics Institute, University of Florida, PO Box 110910, Gainesville, Florida, 32611-0910, USA.

Background: Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in the coding region of PARM1 has been associated with competence of bovine embryos to develop to the blastocyst stage. Here we tested the importance of PARM1 for development by evaluating consequences of reducing PARM1 mRNA abundance on embryonic development and differentiation, gene expression and resistance to ER stress. Read More

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http://dx.doi.org/10.1186/s12861-019-0195-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612098PMC
July 2019
1 Read

A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos.

BMC Dev Biol 2019 07 4;19(1):13. Epub 2019 Jul 4.

School of Biosciences, University of Nottingham, Nottingham, LE12 5RD, UK.

Background: The segregation of the hypoblast and the emergence of the pluripotent epiblast mark the final stages of blastocyst formation in mammalian embryos. In bovine embryos the formation of the hypoblast has been partially studied, and evidence shows that MEK signalling plays a limited role in the segregation of this lineage. Here we explored the role of different signalling pathways during lineage segregation in the bovine embryo using immunofluorescence analysis of NANOG and SOX17 as readouts of epiblast and hypoblast, respectively. Read More

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http://dx.doi.org/10.1186/s12861-019-0193-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610975PMC
July 2019
3 Reads

Electrochemical patterns during Drosophila oogenesis: ion-transport mechanisms generate stage-specific gradients of pH and membrane potential in the follicle-cell epithelium.

BMC Dev Biol 2019 06 21;19(1):12. Epub 2019 Jun 21.

RWTH Aachen University, Institut für Biologie II, Abt. Zoologie und Humanbiologie, Worringerweg 3, 52056, Aachen, Germany.

Background: Alterations of bioelectrical properties of cells and tissues are known to function as wide-ranging signals during development, regeneration and wound-healing in several species. The Drosophila follicle-cell epithelium provides an appropriate model system for studying the potential role of electrochemical signals, like intracellular pH (pH) and membrane potential (V), during development. Therefore, we analysed stage-specific gradients of pH and V as well as their dependence on specific ion-transport mechanisms. Read More

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http://dx.doi.org/10.1186/s12861-019-0192-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588877PMC
June 2019
5 Reads

Growth and cellular patterning during fetal human inner ear development studied by a correlative imaging approach.

BMC Dev Biol 2019 05 20;19(1):11. Epub 2019 May 20.

VetCore Facility for Research, Imaging Unit, University of Veterinary Medicine Vienna, Veterinaerplatz 1, A-1210, Vienna, Austria.

Background: Progressive transformation of the otic placode into the functional inner ear during gestational development in humans leads to the acquisition of hearing perception via the cochlea and balance and spatial orientation via the vestibular organ.

Results: Using a correlative approach involving micro-computerized tomography (micro-CT), transmission electron microscopy and histological techniques we were able to examine both the morphological and cellular changes associated with human inner ear development. Such an evaluation allowed for the examination of 3D geometry with high spatial and temporal resolution. Read More

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http://dx.doi.org/10.1186/s12861-019-0191-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528216PMC
May 2019
5 Reads

An annual cycle of gene regulation in the red-legged salamander mental gland: from hypertrophy to expression of rapidly evolving pheromones.

BMC Dev Biol 2019 04 27;19(1):10. Epub 2019 Apr 27.

Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, 40292, USA.

Background: Cell differentiation is mediated by synchronized waves of coordinated expression for hundreds to thousands of genes, and must be regulated to produce complex tissues and phenotypes. For many animal species, sexual selection has driven the development of elaborate male ornaments, requiring sex-specific differentiation pathways. One such male ornament is the pheromone-producing mental gland of the red-legged salamander (Plethodon shermani). Read More

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http://dx.doi.org/10.1186/s12861-019-0190-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487043PMC
April 2019
4 Reads

Molecular cloning and characteristics of DnaJa1and DnaJb1 in Coilia nasus: possible function involved in oogenesis during spawning migration.

BMC Dev Biol 2019 04 25;19(1). Epub 2019 Apr 25.

Scientific Observing and Experimental Station of Fishery Resources and Environment in the Lower Reaches of the Yangtze River, Ministry of Agriculture and Rural Affaris. Freshwater Fisheries Research Center, CAFS, WuXi, 214081, China.

Background: Coilia nasus oogenesis/spawning migration is a well-defined synchronous arrangement process. DnaJs are indispensable molecular chaperones for oogenesis process. However, how DnaJs involved the anadromous spawning migration mechanism is outstanding and plausible. Read More

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https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861
Publisher Site
http://dx.doi.org/10.1186/s12861-019-0187-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485077PMC
April 2019
18 Reads

Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis.

BMC Dev Biol 2019 04 17;19(1). Epub 2019 Apr 17.

MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

Background: The interstitium of the mouse testis contains Leydig cells and a small number of steroidogenic cells with adrenal characteristics which may be derived from the fetal adrenal during development or may be a normal subset of the developing fetal Leydig cells. Currently it is not known what regulates development and/or proliferation of this sub-population of steroidogenic cells in the mouse testis. Androgen receptors (AR) are essential for normal testicular function and in this study we have examined the role of the AR in regulating interstitial cell development. Read More

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http://dx.doi.org/10.1186/s12861-019-0189-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472051PMC
April 2019
4 Reads

Expression of NK genes that are not part of the NK cluster in the onychophoran Euperipatoides rowelli (Peripatopsidae).

BMC Dev Biol 2019 04 15;19(1). Epub 2019 Apr 15.

Department of Zoology, Institute of Biology, University of Kassel, Kassel, Germany.

Background: NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. They are typically divided into two subgroups, the NK cluster (NKC) and NK-linked genes (NKL). While the NKC genes have been studied in various bilaterians, corresponding data of many NKL genes are missing to date. Read More

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https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861
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http://dx.doi.org/10.1186/s12861-019-0185-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466738PMC
April 2019
1 Read

Clec14a genetically interacts with Etv2 and Vegf signaling during vasculogenesis and angiogenesis in zebrafish.

BMC Dev Biol 2019 04 5;19(1). Epub 2019 Apr 5.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.

Background: C-lectin family 14 Member A (Clec14a) is a transmembrane protein specifically expressed in vascular endothelial cells during embryogenesis. Previous in vitro and in vivo studies have provided conflicting data regarding Clec14a role in promoting or inhibiting angiogenesis, therefore its functional role in vascular development remains poorly understood.

Results: Here we have generated a novel clec14a mutant allele in zebrafish embryos using TALEN genome editing. Read More

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http://dx.doi.org/10.1186/s12861-019-0188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451255PMC

Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development.

BMC Dev Biol 2019 03 25;19(1). Epub 2019 Mar 25.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.

Background: The embryonic day E10-13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiated by the formation of the epicardium on the outer heart surface, which releases insulin-like growth factor 2 (IGF2) as the primary cardiomyocyte mitogen. Two receptors mediate IGF2 signaling, the IGF1R and the insulin receptor (INSR). Read More

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http://dx.doi.org/10.1186/s12861-019-0186-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434851PMC
March 2019
1 Read

Vitellogenins in the spider Parasteatoda tepidariorum - expression profile and putative hormonal regulation of vitellogenesis.

BMC Dev Biol 2019 03 8;19(1). Epub 2019 Mar 8.

Department of Animal Physiology and Ecotoxicology, University of Silesia, Bankowa 9, PL40007, Katowice, Poland.

Background: Knowledge about vitellogenesis in spiders is rudimentary. Therefore, the aim of study was to check the vitellogenin (Vg) presence in various tissues of the female spider Parasteatoda tepidariorum, determine when and where vitellogenesis starts and takes place, and the putative role of selected hormones in the vitellogenesis.

Results: Here we show two genes encoding Vg (PtVg4 and PtVg6) in the genome of the spider P. Read More

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http://dx.doi.org/10.1186/s12861-019-0184-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408786PMC
March 2019
1 Read

Computational fluid dynamic analysis of physical forces playing a role in brain organoid cultures in two different multiplex platforms.

BMC Dev Biol 2019 03 7;19(1). Epub 2019 Mar 7.

D'Or Institute for Research and Education (IDOR), Rua Diniz Cordeiro, 30 - Botafogo, Rio de Janeiro, RJ, 22281-100, Brazil.

Background: Organoid cultivation in suspension culture requires agitation at low shear stress to allow for nutrient diffusion, which preserves tissue structure. Multiplex systems for organoid cultivation have been proposed, but whether they meet similar shear stress parameters as the regularly used spinner flask and its correlation with the successful generation of brain organoids has not been determined.

Results: Here we used computational fluid dynamics (CFD) to simulate two multiplex culture conditions: steering plates on an orbital shaker and the use of a previously described bioreactor. Read More

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http://dx.doi.org/10.1186/s12861-019-0183-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404276PMC
March 2019
4 Reads
2.667 Impact Factor

Interleukin-6 increases inner cell mass numbers in bovine embryos.

BMC Dev Biol 2019 02 1;19(1). Epub 2019 Feb 1.

Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, 3430 Litton-Reaves Hall (0306), Blacksburg, VA, 24060, USA.

Background: Work in other species suggests that interleukin-6 (IL6) promotes early embryo development. It was unclear whether IL6 serves as an embryokine in cultured bovine embryos. This work was undertaken to elucidate the role of IL6 during in vitro bovine embryo production. Read More

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http://dx.doi.org/10.1186/s12861-019-0182-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359871PMC
February 2019

Drosophila ML-DmD17-c3 cells respond robustly to Dpp and exhibit complex transcriptional feedback on BMP signaling components.

BMC Dev Biol 2019 01 22;19(1). Epub 2019 Jan 22.

Center for Vision Research and Department of Ophthalmology, Upstate Medical University, NRB-4610, 505 Irving Ave, Syracuse, 13210, NY, USA.

Background: BMP signaling is involved in myriad metazoan developmental processes, and study of this pathway in Drosophila has contributed greatly to our understanding of its molecular and genetic mechanisms. These studies have benefited not only from Drosophila's advanced genetic tools, but from complimentary in vitro culture systems. However, the commonly-used S2 cell line is not intrinsically sensitive to the major BMP ligand Dpp and must therefore be augmented with exogenous pathway components for most experiments. Read More

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http://dx.doi.org/10.1186/s12861-019-0181-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341649PMC
January 2019
1 Read

Environmental cycles regulate development time via circadian clock mediated gating of adult emergence.

BMC Dev Biol 2018 12 22;18(1):21. Epub 2018 Dec 22.

Behavioural Neurogenetics Laboratory, Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India.

Background: Previous studies have implicated a role for circadian clocks in regulating pre-adult development of organisms. Among them two approaches are most notable: 1) use of insects whose clocks have different free-running periods and 2) imposition of artificial selection on either rate of development, timing of emergence or circadian period in laboratory populations. Using these two approaches, influence of clock on rate of development has been elucidated. Read More

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http://dx.doi.org/10.1186/s12861-018-0180-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303858PMC
December 2018
2 Reads

Histone acetyltransferase CBP-related H3K23 acetylation contributes to courtship learning in Drosophila.

BMC Dev Biol 2018 11 20;18(1):20. Epub 2018 Nov 20.

Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.

Background: Histone modifications are critical in regulating neuronal processes. However, the impacts of individual histone modifications on learning and memory are elusive. Here, we investigated the contributions of histone H3 lysine modifications to learning and memory in Drosophila by using histone lysine-to-alanine mutants. Read More

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http://dx.doi.org/10.1186/s12861-018-0179-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247617PMC
November 2018
37 Reads
2.667 Impact Factor

Fermitin family homolog-2 (FERMT2) is highly expressed in human placental villi and modulates trophoblast invasion.

BMC Dev Biol 2018 11 1;18(1):19. Epub 2018 Nov 1.

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Dr, University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.

Background: Integrins are transmembrane receptors that mediate cell-extracellular matrix (ECM) and cell-cell adhesion and trophoblast cells undergo changes in integrin expression as they differentiate. However, the mechanism(s) of integrin activation leading to integrin-mediated signaling in trophoblast cell differentiation is unknown. The Fermitin family proteins are integrin activators that help mediate integrin-mediated signaling, but have never been studied in detail within the human placenta. Read More

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http://dx.doi.org/10.1186/s12861-018-0178-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211606PMC
November 2018
36 Reads

Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance.

BMC Dev Biol 2018 08 29;18(1):18. Epub 2018 Aug 29.

Department of Psychology and Counselling, School of Psychology and Public Health, La Trobe University, Plenty Rd., Bundoora, Melbourne, VIC, 3083, Australia.

Background: Myopia (short-sightedness) affects approximately 1.4 billion people worldwide, and prevalence is increasing. Animal models induced by defocusing lenses show striking similarity with human myopia in terms of morphology and the implicated genetic pathways. Read More

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http://dx.doi.org/10.1186/s12861-018-0177-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116556PMC
August 2018
34 Reads

Caspases and matrix metalloproteases facilitate collective behavior of non-neural ectoderm after hindbrain neuropore closure.

BMC Dev Biol 2018 07 31;18(1):17. Epub 2018 Jul 31.

Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Background: Mammalian brain is formed through neural tube closure (NTC), wherein both ridges of opposing neural folds are fused in the midline and remodeled in the roof plate of the neural tube and overlying non-neural ectodermal layer. Apoptosis is widely observed from the beginning of NTC at the neural ridges and is crucial for the proper progression of NTC, but its role after the closure remains less clear.

Results: Here, we conducted live-imaging analysis of the mid-hindbrain neuropore (MHNP) closure and revealed unexpected collective behavior of cells surrounding the MHNP. Read More

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http://dx.doi.org/10.1186/s12861-018-0175-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069860PMC
July 2018
5 Reads

Effects of sex on response of the bovine preimplantation embryo to insulin-like growth factor 1, activin A, and WNT7A.

BMC Dev Biol 2018 07 28;18(1):16. Epub 2018 Jul 28.

Department of Animal Sciences, D. H. Barron Reproductive and Perinatal Biology Research Program, and Genetics Institute, University of Florida, Gainesville, PO Box 110910, Gainesville, FL, 32611-0910, USA.

Background: Alterations in maternal environment can sometimes affect embryonic development in a sexually-dimorphic manner. The objective was to determine whether preimplantation bovine embryos respond to three maternally-derived cell signaling molecules in a sex-dependent manner.

Results: Actions of three embryokines known to increase competence of bovine embryos to develop to the blastocyst stage, insulin-like growth factor 1 (IGF1), activin A, and WNT member 7A (WNT7A), were evaluated for actions on embryos produced in vitro with X- or Y- sorted semen from the same bull. Read More

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http://dx.doi.org/10.1186/s12861-018-0176-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064047PMC
July 2018
6 Reads

Contemporaneous effects of diabetes mellitus and hypothyroidism on spermatogenesis and immunolocalization of Claudin-11 inside the seminiferous tubules of mice.

BMC Dev Biol 2018 06 26;18(1):15. Epub 2018 Jun 26.

Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

Background: Diabetes and hypothyroidism produce adverse effects on body weight and sexual maturity by inhibiting body growth and metabolism. The occurrence of diabetes is always accompanied with thyroid dysfunction. Thus, it is important to take hypo- or hyper-thyroidism into consideration when exploring the adverse effects caused by diabetes. Read More

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http://dx.doi.org/10.1186/s12861-018-0174-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019809PMC
June 2018
39 Reads

Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach.

BMC Dev Biol 2018 06 19;18(1):14. Epub 2018 Jun 19.

Instituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal.

Background: Dmrt2a is a zinc finger like transcription factor with several roles during zebrafish early development: left-right asymmetry, synchronisation of the somite clock genes and fast muscle differentiation. Despite the described functions, Dmrt2a mechanism of action is unknown. Therefore, with this work, we propose to identify Dmrt2a downstream genes during zebrafish early development. Read More

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http://dx.doi.org/10.1186/s12861-018-0173-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006574PMC
June 2018
6 Reads

Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster.

BMC Dev Biol 2018 06 14;18(1):13. Epub 2018 Jun 14.

Biology Department, Lewis & Clark College, Portland, USA.

Background: Pregnant women may be exposed to nicotine if they smoke or use tobacco products, nicotine replacement therapy, or via e-cigarettes. Prenatal nicotine exposure has been shown to have deleterious effects on the nervous system in mammals including changes in brain size and in the dopaminergic system. The genetic and molecular mechanisms for these changes are not well understood. Read More

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http://dx.doi.org/10.1186/s12861-018-0172-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001141PMC
June 2018
6 Reads

Cell cycle accumulation of the proliferating cell nuclear antigen PCN-1 transitions from continuous in the adult germline to intermittent in the early embryo of C. elegans.

BMC Dev Biol 2018 05 30;18(1):12. Epub 2018 May 30.

Department of Genetics, Washington University in St. Louis, 660 S. Euclid Ave, St. Louis, MO, 63108, USA.

Background: The proliferating cell nuclear antigen (PCNA or PCN-1 in C. elegans), an essential processivity factor for DNA polymerase δ, has been widely used as a marker of S-phase. In C. Read More

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http://dx.doi.org/10.1186/s12861-018-0171-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977546PMC
May 2018
8 Reads

Dynamic transcriptome landscape of Asian domestic honeybee (Apis cerana) embryonic development revealed by high-quality RNA sequencing.

BMC Dev Biol 2018 04 13;18(1):11. Epub 2018 Apr 13.

Honeybee Research Institute, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.

Background: Honeybee development consists of four stages: embryo, larva, pupa and adult. Embryogenesis, a key process of cell division and differentiation, takes 3 days in honeybees. However, the embryonic transcriptome and the dynamic regulation of embryonic transcription are still largely uncharacterized in honeybees, especially in the Asian honeybee (Apis cerana). Read More

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https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861
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http://dx.doi.org/10.1186/s12861-018-0169-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899340PMC
April 2018
11 Reads

Swimming exercise to control precocious maturation in male seabass (Dicentrarchus labrax).

BMC Dev Biol 2018 04 12;18(1):10. Epub 2018 Apr 12.

Wageningen Marine Research, Wageningen University & Research, Korringaweg 5, 4401, NT, Yerseke, The Netherlands.

Background: Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20-30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses for the industry. In view of the known modulation of reproductive development by swimming exercise in other teleost species, we aimed at investigating the effects of sustained swimming on reproductive development in seabass males during the first year of life in order to determine if swimming could potentially reduce precocious sexual maturation.

Methods: Pre-pubertal seabass (3. Read More

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http://dx.doi.org/10.1186/s12861-018-0170-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897932PMC
April 2018
22 Reads

Molecular signatures of epithelial oviduct cells of a laying hen (Gallus gallus domesticus) and quail (Coturnix japonica).

BMC Dev Biol 2018 04 4;18(1). Epub 2018 Apr 4.

Department of Animal Biochemistry and Biotechnology, UTP University of Science and Technology, Mazowiecka 28, 85-084, Bydgoszcz, Poland.

Background: In this work we have determined molecular signatures of oviduct epithelial and progenitor cells. We have proposed a panel of selected marker genes, which correspond with the phenotype of oviduct cells of a laying hen (Gallus gallus domesticus) and quail (Coturnix japonica). We demonstrated differences in characteristics of those cells, in tissue and in vitro, with respect to different anatomical and functional parts of the oviduct (infundibulum (INF), distal magnum (DM, and proximal magnum (PM)). Read More

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http://dx.doi.org/10.1186/s12861-018-0168-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883888PMC
April 2018
15 Reads

The skeletal ontogeny of Astatotilapia burtoni - a direct-developing model system for the evolution and development of the teleost body plan.

BMC Dev Biol 2018 04 3;18(1). Epub 2018 Apr 3.

Chair in Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, Universitätsstraße 10, 78457, Constance, Germany.

Background: The experimental approach to the evolution and development of the vertebrate skeleton has to a large extent relied on "direct-developing" amniote model organisms, such as the mouse and the chicken. These organisms can however only be partially informative where it concerns secondarily lost features or anatomical novelties not present in their lineages. The widely used anamniotes Xenopus and zebrafish are "indirect-developing" organisms that proceed through an extended time as free-living larvae, before adopting many aspects of their adult morphology, complicating experiments at these stages, and increasing the risk for lethal pleiotropic effects using genetic strategies. Read More

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http://dx.doi.org/10.1186/s12861-018-0166-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883283PMC
April 2018
13 Reads
1 Citation
2.670 Impact Factor