933 results match your criteria BMC developmental biology[Journal]


Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis.

BMC Dev Biol 2019 Apr 17;19(1). Epub 2019 Apr 17.

MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

Background: The interstitium of the mouse testis contains Leydig cells and a small number of steroidogenic cells with adrenal characteristics which may be derived from the fetal adrenal during development or may be a normal subset of the developing fetal Leydig cells. Currently it is not known what regulates development and/or proliferation of this sub-population of steroidogenic cells in the mouse testis. Androgen receptors (AR) are essential for normal testicular function and in this study we have examined the role of the AR in regulating interstitial cell development. Read More

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http://dx.doi.org/10.1186/s12861-019-0189-5DOI Listing

Expression of NK genes that are not part of the NK cluster in the onychophoran Euperipatoides rowelli (Peripatopsidae).

BMC Dev Biol 2019 04 15;19(1). Epub 2019 Apr 15.

Department of Zoology, Institute of Biology, University of Kassel, Kassel, Germany.

Background: NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. They are typically divided into two subgroups, the NK cluster (NKC) and NK-linked genes (NKL). While the NKC genes have been studied in various bilaterians, corresponding data of many NKL genes are missing to date. Read More

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http://dx.doi.org/10.1186/s12861-019-0185-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466738PMC

Clec14a genetically interacts with Etv2 and Vegf signaling during vasculogenesis and angiogenesis in zebrafish.

BMC Dev Biol 2019 04 5;19(1). Epub 2019 Apr 5.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.

Background: C-lectin family 14 Member A (Clec14a) is a transmembrane protein specifically expressed in vascular endothelial cells during embryogenesis. Previous in vitro and in vivo studies have provided conflicting data regarding Clec14a role in promoting or inhibiting angiogenesis, therefore its functional role in vascular development remains poorly understood.

Results: Here we have generated a novel clec14a mutant allele in zebrafish embryos using TALEN genome editing. Read More

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http://dx.doi.org/10.1186/s12861-019-0188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451255PMC

Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development.

BMC Dev Biol 2019 03 25;19(1). Epub 2019 Mar 25.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.

Background: The embryonic day E10-13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiated by the formation of the epicardium on the outer heart surface, which releases insulin-like growth factor 2 (IGF2) as the primary cardiomyocyte mitogen. Two receptors mediate IGF2 signaling, the IGF1R and the insulin receptor (INSR). Read More

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http://dx.doi.org/10.1186/s12861-019-0186-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434851PMC

Vitellogenins in the spider Parasteatoda tepidariorum - expression profile and putative hormonal regulation of vitellogenesis.

BMC Dev Biol 2019 03 8;19(1). Epub 2019 Mar 8.

Department of Animal Physiology and Ecotoxicology, University of Silesia, Bankowa 9, PL40007, Katowice, Poland.

Background: Knowledge about vitellogenesis in spiders is rudimentary. Therefore, the aim of study was to check the vitellogenin (Vg) presence in various tissues of the female spider Parasteatoda tepidariorum, determine when and where vitellogenesis starts and takes place, and the putative role of selected hormones in the vitellogenesis.

Results: Here we show two genes encoding Vg (PtVg4 and PtVg6) in the genome of the spider P. Read More

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http://dx.doi.org/10.1186/s12861-019-0184-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408786PMC

Computational fluid dynamic analysis of physical forces playing a role in brain organoid cultures in two different multiplex platforms.

BMC Dev Biol 2019 03 7;19(1). Epub 2019 Mar 7.

D'Or Institute for Research and Education (IDOR), Rua Diniz Cordeiro, 30 - Botafogo, Rio de Janeiro, RJ, 22281-100, Brazil.

Background: Organoid cultivation in suspension culture requires agitation at low shear stress to allow for nutrient diffusion, which preserves tissue structure. Multiplex systems for organoid cultivation have been proposed, but whether they meet similar shear stress parameters as the regularly used spinner flask and its correlation with the successful generation of brain organoids has not been determined.

Results: Here we used computational fluid dynamics (CFD) to simulate two multiplex culture conditions: steering plates on an orbital shaker and the use of a previously described bioreactor. Read More

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http://dx.doi.org/10.1186/s12861-019-0183-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404276PMC
March 2019
2 Reads
2.667 Impact Factor

Interleukin-6 increases inner cell mass numbers in bovine embryos.

BMC Dev Biol 2019 02 1;19(1). Epub 2019 Feb 1.

Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, 3430 Litton-Reaves Hall (0306), Blacksburg, VA, 24060, USA.

Background: Work in other species suggests that interleukin-6 (IL6) promotes early embryo development. It was unclear whether IL6 serves as an embryokine in cultured bovine embryos. This work was undertaken to elucidate the role of IL6 during in vitro bovine embryo production. Read More

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http://dx.doi.org/10.1186/s12861-019-0182-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359871PMC
February 2019

Drosophila ML-DmD17-c3 cells respond robustly to Dpp and exhibit complex transcriptional feedback on BMP signaling components.

BMC Dev Biol 2019 01 22;19(1). Epub 2019 Jan 22.

Center for Vision Research and Department of Ophthalmology, Upstate Medical University, NRB-4610, 505 Irving Ave, Syracuse, 13210, NY, USA.

Background: BMP signaling is involved in myriad metazoan developmental processes, and study of this pathway in Drosophila has contributed greatly to our understanding of its molecular and genetic mechanisms. These studies have benefited not only from Drosophila's advanced genetic tools, but from complimentary in vitro culture systems. However, the commonly-used S2 cell line is not intrinsically sensitive to the major BMP ligand Dpp and must therefore be augmented with exogenous pathway components for most experiments. Read More

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http://dx.doi.org/10.1186/s12861-019-0181-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341649PMC
January 2019

Environmental cycles regulate development time via circadian clock mediated gating of adult emergence.

BMC Dev Biol 2018 12 22;18(1):21. Epub 2018 Dec 22.

Behavioural Neurogenetics Laboratory, Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India.

Background: Previous studies have implicated a role for circadian clocks in regulating pre-adult development of organisms. Among them two approaches are most notable: 1) use of insects whose clocks have different free-running periods and 2) imposition of artificial selection on either rate of development, timing of emergence or circadian period in laboratory populations. Using these two approaches, influence of clock on rate of development has been elucidated. Read More

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http://dx.doi.org/10.1186/s12861-018-0180-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303858PMC
December 2018
1 Read

Histone acetyltransferase CBP-related H3K23 acetylation contributes to courtship learning in Drosophila.

BMC Dev Biol 2018 11 20;18(1):20. Epub 2018 Nov 20.

Research Center for Translational Medicine at East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.

Background: Histone modifications are critical in regulating neuronal processes. However, the impacts of individual histone modifications on learning and memory are elusive. Here, we investigated the contributions of histone H3 lysine modifications to learning and memory in Drosophila by using histone lysine-to-alanine mutants. Read More

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http://dx.doi.org/10.1186/s12861-018-0179-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247617PMC
November 2018
18 Reads
2.667 Impact Factor

Fermitin family homolog-2 (FERMT2) is highly expressed in human placental villi and modulates trophoblast invasion.

BMC Dev Biol 2018 11 1;18(1):19. Epub 2018 Nov 1.

Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Dr, University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.

Background: Integrins are transmembrane receptors that mediate cell-extracellular matrix (ECM) and cell-cell adhesion and trophoblast cells undergo changes in integrin expression as they differentiate. However, the mechanism(s) of integrin activation leading to integrin-mediated signaling in trophoblast cell differentiation is unknown. The Fermitin family proteins are integrin activators that help mediate integrin-mediated signaling, but have never been studied in detail within the human placenta. Read More

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http://dx.doi.org/10.1186/s12861-018-0178-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211606PMC
November 2018
20 Reads

Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance.

BMC Dev Biol 2018 08 29;18(1):18. Epub 2018 Aug 29.

Department of Psychology and Counselling, School of Psychology and Public Health, La Trobe University, Plenty Rd., Bundoora, Melbourne, VIC, 3083, Australia.

Background: Myopia (short-sightedness) affects approximately 1.4 billion people worldwide, and prevalence is increasing. Animal models induced by defocusing lenses show striking similarity with human myopia in terms of morphology and the implicated genetic pathways. Read More

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http://dx.doi.org/10.1186/s12861-018-0177-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116556PMC
August 2018
15 Reads

Caspases and matrix metalloproteases facilitate collective behavior of non-neural ectoderm after hindbrain neuropore closure.

BMC Dev Biol 2018 07 31;18(1):17. Epub 2018 Jul 31.

Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Background: Mammalian brain is formed through neural tube closure (NTC), wherein both ridges of opposing neural folds are fused in the midline and remodeled in the roof plate of the neural tube and overlying non-neural ectodermal layer. Apoptosis is widely observed from the beginning of NTC at the neural ridges and is crucial for the proper progression of NTC, but its role after the closure remains less clear.

Results: Here, we conducted live-imaging analysis of the mid-hindbrain neuropore (MHNP) closure and revealed unexpected collective behavior of cells surrounding the MHNP. Read More

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http://dx.doi.org/10.1186/s12861-018-0175-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069860PMC
July 2018
3 Reads

Effects of sex on response of the bovine preimplantation embryo to insulin-like growth factor 1, activin A, and WNT7A.

BMC Dev Biol 2018 07 28;18(1):16. Epub 2018 Jul 28.

Department of Animal Sciences, D. H. Barron Reproductive and Perinatal Biology Research Program, and Genetics Institute, University of Florida, Gainesville, PO Box 110910, Gainesville, FL, 32611-0910, USA.

Background: Alterations in maternal environment can sometimes affect embryonic development in a sexually-dimorphic manner. The objective was to determine whether preimplantation bovine embryos respond to three maternally-derived cell signaling molecules in a sex-dependent manner.

Results: Actions of three embryokines known to increase competence of bovine embryos to develop to the blastocyst stage, insulin-like growth factor 1 (IGF1), activin A, and WNT member 7A (WNT7A), were evaluated for actions on embryos produced in vitro with X- or Y- sorted semen from the same bull. Read More

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http://dx.doi.org/10.1186/s12861-018-0176-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064047PMC
July 2018
3 Reads

Contemporaneous effects of diabetes mellitus and hypothyroidism on spermatogenesis and immunolocalization of Claudin-11 inside the seminiferous tubules of mice.

BMC Dev Biol 2018 06 26;18(1):15. Epub 2018 Jun 26.

Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.

Background: Diabetes and hypothyroidism produce adverse effects on body weight and sexual maturity by inhibiting body growth and metabolism. The occurrence of diabetes is always accompanied with thyroid dysfunction. Thus, it is important to take hypo- or hyper-thyroidism into consideration when exploring the adverse effects caused by diabetes. Read More

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http://dx.doi.org/10.1186/s12861-018-0174-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019809PMC
June 2018
17 Reads

Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach.

BMC Dev Biol 2018 06 19;18(1):14. Epub 2018 Jun 19.

Instituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisboa, Portugal.

Background: Dmrt2a is a zinc finger like transcription factor with several roles during zebrafish early development: left-right asymmetry, synchronisation of the somite clock genes and fast muscle differentiation. Despite the described functions, Dmrt2a mechanism of action is unknown. Therefore, with this work, we propose to identify Dmrt2a downstream genes during zebrafish early development. Read More

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http://dx.doi.org/10.1186/s12861-018-0173-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006574PMC
June 2018
4 Reads

Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster.

BMC Dev Biol 2018 06 14;18(1):13. Epub 2018 Jun 14.

Biology Department, Lewis & Clark College, Portland, USA.

Background: Pregnant women may be exposed to nicotine if they smoke or use tobacco products, nicotine replacement therapy, or via e-cigarettes. Prenatal nicotine exposure has been shown to have deleterious effects on the nervous system in mammals including changes in brain size and in the dopaminergic system. The genetic and molecular mechanisms for these changes are not well understood. Read More

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http://dx.doi.org/10.1186/s12861-018-0172-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001141PMC
June 2018
3 Reads

Cell cycle accumulation of the proliferating cell nuclear antigen PCN-1 transitions from continuous in the adult germline to intermittent in the early embryo of C. elegans.

BMC Dev Biol 2018 05 30;18(1):12. Epub 2018 May 30.

Department of Genetics, Washington University in St. Louis, 660 S. Euclid Ave, St. Louis, MO, 63108, USA.

Background: The proliferating cell nuclear antigen (PCNA or PCN-1 in C. elegans), an essential processivity factor for DNA polymerase δ, has been widely used as a marker of S-phase. In C. Read More

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http://dx.doi.org/10.1186/s12861-018-0171-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977546PMC
May 2018
6 Reads

Dynamic transcriptome landscape of Asian domestic honeybee (Apis cerana) embryonic development revealed by high-quality RNA sequencing.

BMC Dev Biol 2018 04 13;18(1):11. Epub 2018 Apr 13.

Honeybee Research Institute, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.

Background: Honeybee development consists of four stages: embryo, larva, pupa and adult. Embryogenesis, a key process of cell division and differentiation, takes 3 days in honeybees. However, the embryonic transcriptome and the dynamic regulation of embryonic transcription are still largely uncharacterized in honeybees, especially in the Asian honeybee (Apis cerana). Read More

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https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861
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http://dx.doi.org/10.1186/s12861-018-0169-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899340PMC
April 2018
9 Reads

Swimming exercise to control precocious maturation in male seabass (Dicentrarchus labrax).

BMC Dev Biol 2018 04 12;18(1):10. Epub 2018 Apr 12.

Wageningen Marine Research, Wageningen University & Research, Korringaweg 5, 4401, NT, Yerseke, The Netherlands.

Background: Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20-30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses for the industry. In view of the known modulation of reproductive development by swimming exercise in other teleost species, we aimed at investigating the effects of sustained swimming on reproductive development in seabass males during the first year of life in order to determine if swimming could potentially reduce precocious sexual maturation.

Methods: Pre-pubertal seabass (3. Read More

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http://dx.doi.org/10.1186/s12861-018-0170-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897932PMC
April 2018
8 Reads

Molecular signatures of epithelial oviduct cells of a laying hen (Gallus gallus domesticus) and quail (Coturnix japonica).

BMC Dev Biol 2018 04 4;18(1). Epub 2018 Apr 4.

Department of Animal Biochemistry and Biotechnology, UTP University of Science and Technology, Mazowiecka 28, 85-084, Bydgoszcz, Poland.

Background: In this work we have determined molecular signatures of oviduct epithelial and progenitor cells. We have proposed a panel of selected marker genes, which correspond with the phenotype of oviduct cells of a laying hen (Gallus gallus domesticus) and quail (Coturnix japonica). We demonstrated differences in characteristics of those cells, in tissue and in vitro, with respect to different anatomical and functional parts of the oviduct (infundibulum (INF), distal magnum (DM, and proximal magnum (PM)). Read More

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http://dx.doi.org/10.1186/s12861-018-0168-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883888PMC
April 2018
12 Reads

The skeletal ontogeny of Astatotilapia burtoni - a direct-developing model system for the evolution and development of the teleost body plan.

BMC Dev Biol 2018 04 3;18(1). Epub 2018 Apr 3.

Chair in Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, Universitätsstraße 10, 78457, Constance, Germany.

Background: The experimental approach to the evolution and development of the vertebrate skeleton has to a large extent relied on "direct-developing" amniote model organisms, such as the mouse and the chicken. These organisms can however only be partially informative where it concerns secondarily lost features or anatomical novelties not present in their lineages. The widely used anamniotes Xenopus and zebrafish are "indirect-developing" organisms that proceed through an extended time as free-living larvae, before adopting many aspects of their adult morphology, complicating experiments at these stages, and increasing the risk for lethal pleiotropic effects using genetic strategies. Read More

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http://dx.doi.org/10.1186/s12861-018-0166-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883283PMC
April 2018
6 Reads
1 Citation
2.670 Impact Factor

Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster.

BMC Dev Biol 2018 03 27;18(1). Epub 2018 Mar 27.

National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi'an, 710062, China.

Background: FK506-binding proteins (FKBPs) have become the subject of considerable interest in several fields, leading to the identification of several cellular and molecular pathways in which FKBPs impact prenatal development and pathogenesis of many human diseases.

Main Body: This analysis revealed differences between how mammalian and Drosophila FKBPs mechanisms function in relation to the immunosuppressant drugs, FK506 and rapamycin. Differences that could be used to design insect-specific pesticides. Read More

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http://dx.doi.org/10.1186/s12861-018-0167-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870485PMC
March 2018
28 Reads

A parental requirement for dual-specificity phosphatase 6 in zebrafish.

BMC Dev Biol 2018 03 15;18(1). Epub 2018 Mar 15.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.

Background: Signaling cascades, such as the extracellular signal-regulated kinase (ERK) pathway, play vital roles in early vertebrate development. Signals through these pathways are initiated by a growth factor or hormone, are transduced through a kinase cascade, and result in the expression of specific downstream genes that promote cellular proliferation, growth, or differentiation. Tight regulation of these signals is provided by positive or negative modulators at varying levels in the pathway, and is required for proper development and function. Read More

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http://dx.doi.org/10.1186/s12861-018-0164-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856328PMC
March 2018
5 Reads

Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos.

BMC Dev Biol 2018 03 5;18(1). Epub 2018 Mar 5.

Institutes of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.

Background: Tbx5 deficiency in zebrafish causes several abnormal phenotypes of the heart and pectoral fins. It has been reported that exogenous human growth hormone can enhance expression of downstream mediators in the growth hormone and insulin-like growth factor I (IGF-I) pathway and partially restore dysmorphogenesis in tbx5 morphants. This study aimed to further evaluate the effects of IGF-I on cell apoptosis and dysmorphogenesis in zebrafish embryos deficient for tbx5. Read More

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http://dx.doi.org/10.1186/s12861-017-0161-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836385PMC
March 2018
16 Reads

Evidence for a centrosome-attracting body like structure in germ-soma segregation during early development, in the urochordate Oikopleura dioica.

BMC Dev Biol 2018 02 27;18(1). Epub 2018 Feb 27.

Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway.

Background: Germ cell formation has been investigated in sessile forms of tunicates. This process involves the release of a subset of maternal transcripts from the centrosome-attracting body (CAB) in the progenitor cells of the germ line. When germ-soma segregation is completed, CAB structures are missing from the newly formed primordial germ cells (PGCs). Read More

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http://dx.doi.org/10.1186/s12861-018-0165-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830320PMC
February 2018
18 Reads

Expression and function of microRNA-9 in the mid-hindbrain area of embryonic chick.

BMC Dev Biol 2018 02 22;18(1). Epub 2018 Feb 22.

Institute of Clinical Anatomy and Cell Analysis, University of Tuebingen, Oesterbergstrasse 3, D-72074, Tuebingen, Germany.

Background: MiR-9 is a small non-coding RNA that is highly conserved between species and primarily expressed in the central nervous system (CNS). It is known to influence proliferation and neuronal differentiation in the brain and spinal cord of different vertebrates. Different studies have pointed to regional and species-specific differences in the response of neural progenitors to miR-9. Read More

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http://dx.doi.org/10.1186/s12861-017-0159-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824543PMC
February 2018
6 Reads

Dynamics of promoter bivalency and RNAP II pausing in mouse stem and differentiated cells.

BMC Dev Biol 2018 02 20;18(1). Epub 2018 Feb 20.

Division of Developmental Biology, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, UK.

Background: Mammalian embryonic stem cells display a unique epigenetic and transcriptional state to facilitate pluripotency by maintaining lineage-specification genes in a poised state. Two epigenetic and transcription processes involved in maintaining poised state are bivalent chromatin, characterized by the simultaneous presence of activating and repressive histone methylation marks, and RNA polymerase II (RNAPII) promoter proximal pausing. However, the dynamics of histone modifications and RNAPII at promoters in diverse cellular contexts remains underexplored. Read More

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http://dx.doi.org/10.1186/s12861-018-0163-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819258PMC
February 2018
5 Reads

Opsin expression patterns coincide with photoreceptor development during pupal development in the honey bee, Apis mellifera.

BMC Dev Biol 2018 01 30;18(1). Epub 2018 Jan 30.

Department of Behavioral Physiology and Sociobiology, Biozentrum, University of Würzburg, Würzburg, Germany.

Background: The compound eyes of insects allow them to catch photons and convert the energy into electric signals. All compound eyes consist of numerous ommatidia, each comprising a fixed number of photoreceptors. Different ommatidial types are characterized by a specific set of photoreceptors differing in spectral sensitivity. Read More

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http://dx.doi.org/10.1186/s12861-018-0162-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791347PMC
January 2018
10 Reads

In vivo imaging of epithelial wound healing in the cnidarian Clytia hemisphaerica demonstrates early evolution of purse string and cell crawling closure mechanisms.

BMC Dev Biol 2017 12 19;17(1):17. Epub 2017 Dec 19.

Department of Molecular Genetics and Cell Biology, The University of Chicago, 929 East 57th Street, Chicago, IL, 60637, USA.

Background: All animals have mechanisms for healing damage to the epithelial sheets that cover the body and line internal cavities. Epithelial wounds heal either by cells crawling over the wound gap, by contraction of a super-cellular actin cable ("purse string") that surrounds the wound, or some combination of the two mechanisms. Both cell crawling and purse string closure of epithelial wounds are widely observed across vertebrates and invertebrates, suggesting early evolution of these mechanisms. Read More

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http://dx.doi.org/10.1186/s12861-017-0160-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735930PMC
December 2017
18 Reads

The asymmetric cell division machinery in the spiral-cleaving egg and embryo of the marine annelid Platynereis dumerilii.

BMC Dev Biol 2017 Dec 11;17(1):16. Epub 2017 Dec 11.

Department of Genetics, Development and Cell Biology, Iowa State University, 503 Science Hall II, Ames, IA, 50011, USA.

Background: Over one third of all animal phyla utilize a mode of early embryogenesis called 'spiral cleavage' to divide the fertilized egg into embryonic cells with different cell fates. This mode is characterized by a series of invariant, stereotypic, asymmetric cell divisions (ACDs) that generates cells of different size and defined position within the early embryo. Astonishingly, very little is known about the underlying molecular machinery to orchestrate these ACDs in spiral-cleaving embryos. Read More

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https://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861
Publisher Site
http://dx.doi.org/10.1186/s12861-017-0158-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725810PMC
December 2017
15 Reads

Tol2 transposon-mediated transgenesis in the Midas cichlid (Amphilophus citrinellus) - towards understanding gene function and regulatory evolution in an ecological model system for rapid phenotypic diversification.

BMC Dev Biol 2017 Nov 23;17(1):15. Epub 2017 Nov 23.

Chair in Zoology and Evolutionary Biology, Department of Biology, University of Konstanz, Constance, Germany.

Background: The Midas cichlid species complex (Amphilophus spp.) is widely known among evolutionary biologists as a model system for sympatric speciation and adaptive phenotypic divergence within extremely short periods of time (a few hundred generations). The repeated parallel evolution of adaptive phenotypes in this radiation, combined with their near genetic identity, makes them an excellent model for studying phenotypic diversification. Read More

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http://dx.doi.org/10.1186/s12861-017-0157-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701313PMC
November 2017
9 Reads

Unique N-terminal sequences in two Runx1 isoforms are dispensable for Runx1 function.

BMC Dev Biol 2017 10 18;17(1):14. Epub 2017 Oct 18.

Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS). 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.

Background: The Runt-related transcription factors (Runx) are a family of evolutionarily conserved transcriptional regulators that play multiple roles in the developmental control of various cell types. Among the three mammalian Runx proteins, Runx1 is essential for definitive hematopoiesis and its dysfunction leads to human leukemogenesis. There are two promoters, distal (P1) and proximal (P2), in the Runx1 gene, which produce two Runx1 isoforms with distinct N-terminal amino acid sequences, P1-Runx1 and P2-Runx1. Read More

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http://dx.doi.org/10.1186/s12861-017-0156-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648507PMC
October 2017
10 Reads

Respective contribution of the cephalic neural crest and mesoderm to SIX1-expressing head territories in the avian embryo.

BMC Dev Biol 2017 10 10;17(1):13. Epub 2017 Oct 10.

Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France.

Background: Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC), which generates most of craniofacial skeleton, dermis, pericytes, fat cells, and tenocytes; and - the mesoderm, which yields muscles, blood vessel endothelia and some posterior cranial bones. The molecular players that orchestrate co-development of cephalic NC and mesodermal cells to properly construct the head of vertebrates remain poorly understood. Read More

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http://dx.doi.org/10.1186/s12861-017-0155-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634862PMC
October 2017
16 Reads

Integrative analysis of the Pekin duck (Anas anas) MicroRNAome during feather follicle development.

BMC Dev Biol 2017 07 20;17(1):12. Epub 2017 Jul 20.

College of Animal Science and Technology, Anhui Agricultural University, Hefei, People's Republic of China.

Background: The quality and yield of duck feathers are very important economic traits that might be controlled by miRNA regulation. The aim of the present study was to investigate the mechanism underlying the crosstalk between individual miRNAs and the activity of signaling pathways that control the growth of duck feathers during different periods. We therefore conducted a comprehensive investigation using Solexa sequencing technology on the Pekin duck microRNAome over six stages of feather development at days 11, 15, and 20 of embryonic development (during the hatching period), and at 1 day and 4 and 10 weeks posthatch. Read More

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http://dx.doi.org/10.1186/s12861-017-0153-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520360PMC
July 2017
11 Reads

Phylogeny, expression patterns and regulation of DNA Methyltransferases in early development of the flatfish, Solea senegalensis.

BMC Dev Biol 2017 07 17;17(1):11. Epub 2017 Jul 17.

IFAPA Centro El Toruño, Junta de Andalucía, Camino Tiro Pichón s/n, 11500 El Puerto de Santa María, Cádiz, Spain.

Background: The identification of DNA methyltransferases (Dnmt) expression patterns during development and their regulation is important to understand the epigenetic mechanisms that modulate larval plasticity in marine fish. In this study, dnmt1 and dnmt3 paralogs were identified in the flatfish Solea senegalensis and expression patterns in early developmental stages and juveniles were determined. Additionally, the regulation of Dnmt transcription by a specific inhibitor (5-aza-2'-deoxycytidine) and temperature was evaluated. Read More

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http://dx.doi.org/10.1186/s12861-017-0154-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513168PMC
July 2017
24 Reads

Cathepsin B inhibitor improves developmental competency and cryo-tolerance of in vitro ovine embryos.

BMC Dev Biol 2017 07 4;17(1):10. Epub 2017 Jul 4.

Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Royan St., Salman St., Khorasgan, Jey St, Isfahan, 8159358686, Iran.

Background: Cathepsin B is a lysosomal cysteine protease involved in apoptosis and oocytes which have lower developmental competence show higher expression of Cathepsin B. Furthermore, expression of Cathepsin B show a decreasing trend from oocyte toward blastocyst stage.

Results: Present study assessed the effect of cathepsin B inhibitor, E-64, on developmental competency and cryo-survival of pre-implantation ovine IVF derived embryos. Read More

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http://dx.doi.org/10.1186/s12861-017-0152-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496377PMC
July 2017
12 Reads

Expression of Ciona intestinalis AOX causes male reproductive defects in Drosophila melanogaster.

BMC Dev Biol 2017 07 3;17(1). Epub 2017 Jul 3.

Institute of Biosciences and Medical Technology, Tampere University Hospital, University of Tampere, FI-33014, Tampere, Finland.

Background: Mitochondrial alternative respiratory-chain enzymes are phylogenetically widespread, and buffer stresses affecting oxidative phosphorylation in species that possess them. However, they have been lost in the evolutionary lineages leading to vertebrates and arthropods, raising the question as to what survival or reproductive disadvantages they confer. Recent interest in using them in therapy lends a biomedical dimension to this question. Read More

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http://dx.doi.org/10.1186/s12861-017-0151-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496232PMC
July 2017
34 Reads

Comparison of two related lines of tauGFP transgenic mice designed for lineage tracing.

BMC Dev Biol 2017 06 29;17(1). Epub 2017 Jun 29.

Genes and Development Group, Centre for Integrative Physiology, Clinical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.

Background: The tauGFP reporter fusion protein is produced nearly ubiquitously by the TgTP6.3 transgene in TP6.3 mice and its localisation to microtubules offers some advantages over soluble GFP as a lineage marker. Read More

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http://dx.doi.org/10.1186/s12861-017-0149-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492368PMC
June 2017
40 Reads

The many faces of Pluripotency: in vitro adaptations of a continuum of in vivo states.

BMC Dev Biol 2017 06 13;17(1). Epub 2017 Jun 13.

Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic, as well as germ cells. The epiblast of the early mammalian embryo is the founder population of all germ layer derivatives and thus represents the bona fide in vivo pluripotent cell population. The so-called pluripotent state spans several days of development and is lost during gastrulation as epiblast cells make fate decisions towards a mesoderm, endoderm or ectoderm identity. Read More

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http://dx.doi.org/10.1186/s12861-017-0150-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470286PMC
June 2017
36 Reads

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.

BMC Dev Biol 2017 04 26;17(1). Epub 2017 Apr 26.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK.

Background: Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomalies including cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patterning defects, and tracheo-oesophageal and anorectal malformations, and is a model for VACTERL/caudal regression/Currarino syndromes (VACTERL association - Vertebral anomalies, Anal atresia, Cardiac defects, Tracheoesophageal fistula and/or Esophageal atresia, Renal & Radial anomalies and Limb defects).

Results: Using magnetic resonance imaging (MRI), we examined heart development in mouse embryos with zygotic and cardiac specific deletion of Pcsk5. We show that conditional deletion of Pcsk5 in all epiblastic lineages recapitulates all developmental malformations except for tracheo-esophageal malformations. Read More

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http://dx.doi.org/10.1186/s12861-017-0148-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407003PMC
April 2017
14 Reads

Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.

BMC Dev Biol 2017 04 13;17(1). Epub 2017 Apr 13.

Centre for Cancer Biology, University of South Australia and SA Pathology, Frome Road, Adelaide, SA, 5000, Australia.

Background: Cranial neural crest cells (NCCs) are a unique embryonic cell type which give rise to a diverse array of derivatives extending from neurons and glia through to bone and cartilage. Depending on their point of origin along the antero-posterior axis cranial NCCs are rapidly sorted into distinct migratory streams that give rise to axial specific structures. These migratory streams mirror the underlying segmentation of the brain with NCCs exiting the diencephalon and midbrain following distinct paths compared to those exiting the hindbrain rhombomeres (r). Read More

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http://dx.doi.org/10.1186/s12861-017-0147-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390458PMC
April 2017
22 Reads

Nodal and BMP expression during the transition to pentamery in the sea urchin Heliocidaris erythrogramma: insights into patterning the enigmatic echinoderm body plan.

BMC Dev Biol 2017 02 13;17(1). Epub 2017 Feb 13.

School of Medical Science and Bosch Institute, The University of Sydney, Sydney, NSW, 2006, Australia.

Background: The molecular mechanisms underlying the development of the unusual echinoderm pentameral body plan and their likeness to mechanisms underlying the development of the bilateral plans of other deuterostomes are of interest in tracing body plan evolution. In this first study of the spatial expression of genes associated with Nodal and BMP2/4 signalling during the transition to pentamery in sea urchins, we investigate Heliocidaris erythrogramma, a species that provides access to the developing adult rudiment within days of fertilization.

Results: BMP2/4, and the putative downstream genes, Six1/2, Eya, Tbx2/3 and Msx were expressed in the earliest morphological manifestation of pentamery during development, the five hydrocoele lobes. Read More

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http://dx.doi.org/10.1186/s12861-017-0145-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307799PMC
February 2017
12 Reads

A compendium of developmental gene expression in Lake Malawi cichlid fishes.

BMC Dev Biol 2017 02 3;17(1). Epub 2017 Feb 3.

Georgia Institute of Technology, School of Biological Sciences and Institute for Bioengineering and Bioscience, Atlanta, GA, USA.

Background: Lake Malawi cichlids represent one of a growing number of vertebrate models used to uncover the genetic and developmental basis of trait diversity. Rapid evolutionary radiation has resulted in species that share similar genomes but differ markedly in phenotypes including brains and behavior, nuptial coloration and the craniofacial skeleton. Research has begun to identify the genes, as well as the molecular and developmental pathways that underlie trait divergence. Read More

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http://dx.doi.org/10.1186/s12861-017-0146-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291978PMC
February 2017
7 Reads

Embryogenesis in the parasitic nematode Heterodera glycines is independent of host-derived hatching stimulation.

BMC Dev Biol 2017 01 11;17(1). Epub 2017 Jan 11.

Department of Crop Sciences, University of Illinois at Urbana-Champaign, 1102 S. Goodwin Ave, Urbana, 61801, IL, USA.

Background: Many parasites regulate their development to synchronize their life cycle with a compatible host. The parasitic nematode Heterodera glycines displays incomplete host-mediated hatching behavior wherein some H. glycines individuals hatch only in the presence of a host-derived cue while others hatch in water alone. Read More

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http://dx.doi.org/10.1186/s12861-016-0144-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225516PMC
January 2017
25 Reads

The essential requirement of an animal heme peroxidase protein during the wing maturation process in Drosophila.

BMC Dev Biol 2017 01 11;17(1). Epub 2017 Jan 11.

Biology Department, Howard University, 415 College Street, 20059, Washington, DC, NW, USA.

Background: Thus far, a handful of genes have been shown to be related to the wing maturation process in insects. A novel heme peroxidase enzyme known as curly suppressor (Cysu)(formerly CG5873), have been characterized in this report because it is involved in wing morphogenesis. Using bioinformatics tools we found that Cysu is remarkably conserved in the genus Drosophila (>95%) as well as in invertebrates (>70%), although its vertebrate orthologs show poor homology. Read More

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http://dx.doi.org/10.1186/s12861-016-0143-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225594PMC
January 2017
13 Reads

Changes of gonadotropin-releasing hormone receptor 2 during the anadromous spawning migration in Coilia nasus.

BMC Dev Biol 2016 11 24;16(1):42. Epub 2016 Nov 24.

Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, 430070, China.

Background: An increase in the activity of the pituitary-gonad axis (PG-axis) and gonad development are essential for the onset of spawning migration in teleosts. In the fish Coilia nasus, gonad development and spawning migration up the Yangtze River occurs by the end of each summer. We hypothesized that gonadotropin releasing hormones receptor 2 (GnRH-R2), which together produce a signal that interacts with the PG-axis, may help to regulate spawning migration processes. Read More

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http://dx.doi.org/10.1186/s12861-016-0142-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122156PMC
November 2016
14 Reads

Microarray analysis reveals a potential role of LncRNAs expression in cardiac cell proliferation.

BMC Dev Biol 2016 11 18;16(1):41. Epub 2016 Nov 18.

Children's Heart Center, the Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, No. 109, Xueyuan Road, Wenzhou, 325000, Zhejiang Province, People's Republic of China.

Background: Long non-coding RNAs (LncRNAs) have been identified to play important roles in epigenetic processes that underpin organogenesis. However, the role of LncRNAs in the regulation of transition from fetal to adult life of human heart has not been evaluated.

Methods: Immunofiuorescent staining was used to determine the extent of cardiac cell proliferation. Read More

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http://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-
Publisher Site
http://dx.doi.org/10.1186/s12861-016-0139-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116129PMC
November 2016
12 Reads

Diversity of human and mouse homeobox gene expression in development and adult tissues.

BMC Dev Biol 2016 11 3;16(1):40. Epub 2016 Nov 3.

Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK.

Background: Homeobox genes encode a diverse set of transcription factors implicated in a vast range of biological processes including, but not limited to, embryonic cell fate specification and patterning. Although numerous studies report expression of particular sets of homeobox genes, a systematic analysis of the tissue specificity of homeobox genes is lacking.

Results: Here we analyse publicly-available transcriptome data from human and mouse developmental stages, and adult human tissues, to identify groups of homeobox genes with similar expression patterns. Read More

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http://dx.doi.org/10.1186/s12861-016-0140-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094009PMC
November 2016
15 Reads

Left-right axis asymmetry determining human Cryptic gene is transcriptionally repressed by Snail.

BMC Dev Biol 2016 10 28;16(1):39. Epub 2016 Oct 28.

Department of Biotechnology, Bhupat & Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036, India.

Background: Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in initiating the specification of the axis; the downstream events, however, are regulated by signal-transduction and gene-expression changes identifying which remains a crucial challenge. The EGF-CFC family member Cryptic, that functions as a co-receptor for some TGF-beta ligands, is developmentally expressed in higher mammals and mutations in the gene cause loss or change in left-right axis asymmetry. Read More

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http://bmcdevbiol.biomedcentral.com/articles/10.1186/s12861-
Publisher Site
http://dx.doi.org/10.1186/s12861-016-0141-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084438PMC
October 2016
16 Reads