782 results match your criteria BMC Urology[Journal]


Preoperative neutrophil-to-lymphocyte ratio predicts the surgical outcome of Xp11.2 translocation/TFE3 renal cell carcinoma patients.

BMC Urol 2018 Jun 11;18(1):60. Epub 2018 Jun 11.

Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu Province, China.

Background: The preoperative neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CRP/Alb ratio) and platelet-to-lymphocyte ratio (PLR) have been demonstrated to predict the clinical outcome of various human cancer, including renal cell carcinoma(RCC). The aim of our study was to explore the prognostic values of these ratios in patients with Xp11.2 translocation/TFE3 gene fusions renal cell carcinoma (Xp11. Read More

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June 2018
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Prognostic significance of epidermal growth factor receptor (EGFR) over expression in urothelial carcinoma of urinary bladder.

BMC Urol 2018 Jun 7;18(1):59. Epub 2018 Jun 7.

Brown University, Providence, RI, USA.

Background: Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency of over expression in bladder cancer has not been studied in our population; therefore we aimed to evaluate the frequency and prognostic significance of EGFR immunohistochemical expression in locoregional population.

Methods: We performed EGFR immunohistochemistry on 126 cases of bladder cancer and association of EGFR expression with tumor grade, lamina propria invasion, deep muscle invasion and recurrence of disease was evaluated. Read More

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With a new clip technique surgically inducing varicocele in Sprague-Dawley rats.

BMC Urol 2018 Jun 7;18(1):58. Epub 2018 Jun 7.

Department of Urology, the Third Affiliated Hospital of Southern Medical University, No. 183 West Zhongshan Road, Tianhe District, 510630, Guangzhou, People's Republic of China.

Background: We introduced and recreated a more consistent and effective experimental varicocele rat model by a new clip technique.

Methods: A total of 40 rats were numbered and randomly assigned to 5 groups of 8 each, including sham surgery (Group I), conventional (Group II) and clip groups with 0.7, 0. Read More

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Observation versus treatment among men with favorable risk prostate cancer in a community-based integrated health care system: a retrospective cohort study.

BMC Urol 2018 Jun 4;18(1):55. Epub 2018 Jun 4.

Wayne State University School of Medicine and the Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.

Background: The objective of this study was to describe overall survival and the management of men with favorable risk prostate cancer (PCa) within a large community-based health care system in the United States.

Methods: A retrospective cohort study was conducted using linked electronic health records from men aged ≥40 years with favorable risk PCa (T1 or 2, PSA ≤15, Gleason ≤7 [3 + 4]) diagnosed between January 2005 and October 2013. Cohorts were defined as receiving any treatment (IMT) or no treatment (OBS) within 6 months after index PCa diagnosis. Read More

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June 2018
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Knowledge and attitude for overactive bladder care among women: development and measurement.

BMC Urol 2018 Jun 5;18(1):56. Epub 2018 Jun 5.

Departments of Medicine and Surgery, Divisions of Geriatrics and Urology, Perelman School of Medicine Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Background: Overactive bladder (OAB) affects millions of women. It is important to assess knowledge and attitude in affected patients. The study objective was to develop surveys to assess OAB knowledge and OAB related attitude, and its association with OAB treatment status. Read More

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June 2018
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Nephron-sparing management of Xanthogranulomatous pyelonephritis presenting as spontaneous renal hemorrhage: a case report and literature review.

BMC Urol 2018 Jun 5;18(1):57. Epub 2018 Jun 5.

Department of Urology, Wake Forest Baptist Health, Medical Center Blvd, Winston-Salem, NC, 27157, USA.

Background: Xanthogranulomatous pyelonephritis (XGP) is an uncommon infectious disease of the kidney known to mimic other renal maladies. A rare presentation of this uncommon disease is spontaneous renal hemorrhage (SRH).

Case Presentation: We report a case of XGP in a 58 year old woman who presented with abdominal pain, hematuria, and radiating left flank pain. Read More

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June 2018
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Does anchoring vaginal mesh increase the potential for correcting stress incontinence?

BMC Urol 2018 May 31;18(1):53. Epub 2018 May 31.

Department of Obstetrics and Gynaecology, Blekinge Hospital, Karlskrona, Sweden.

Background: This study aims to explore the feasibility of anchoring a four-arm transvaginal mesh (TVM) to the mid-urethra to correct an anterior compartment POP-Quantification stage II-III (Q II-III) and concomitant genuine SUI.

Methods: We analysed clinical data from 248 patients with stage II-III anterior prolapse and concomitant SUI who had undergone surgery at a tertiary referral centre in Hungary between January 2008 and June 2010. One hundred and twenty-four women treated with anterior colporrhaphy and 62 patients implanted with a conventional permanent TVM were selected as historical matched controls. Read More

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May 2018
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Daily tadalafil for the chronic phase of stuttering priapism: a case report.

BMC Urol 2018 May 31;18(1):54. Epub 2018 May 31.

Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy.

Background: Recurrent (stuttering) ischemic priapism is a challenging clinical condition. Frequent recurrences result in frequent hospital admissions whereas treatment with a shunting procedure often results in erectile dysfunction.

Case Presentation: A 22-year-old man with stuttering idiopathic priapism developed erectile dysfunction (IIEF-5 score 12) following a Winter's shunt; he was given tadalafil, 5 mg/daily, for 6 months. Read More

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May 2018
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The location of the bladder neck in postoperative cystography predicts continence convalescence after radical prostatectomy.

BMC Urol 2018 May 30;18(1):52. Epub 2018 May 30.

Department of Urology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Background: This study was conducted to determine whether the location of the bladder neck in postoperative cystography predicts recovery of continence after radical prostatectomy.

Methods: Between 2008 and 2015, 203 patients who underwent laparoscopic radical prostatectomy (LRP, n = 99) and robot assisted radical prostatectomy (RARP, n = 104) were analyzed. The location of the bladder neck was visualized by postoperative routine cystography, and quantitative evaluation of the bladder neck position was performed according to the bladder neck to pubic symphysis (BNPS) ratio proposed by Olgin et al. Read More

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May 2018
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Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally?

BMC Urol 2018 May 29;18(1):50. Epub 2018 May 29.

University Hospital of Federal University of Maranhão, Barão de Itapari Street, Centro, São Luís, Brazil.

Background: The objectives of this study were to determine the minimum incidence of penile cancer in the poorest Brazilian state, and to describe the epidemiologic and clinical characteristics of patients diagnosed with the disease.

Methods: A retrospective study of 392 patients diagnosed with penile cancer in the three most important referral center in the state was conducted during 2004-2014.

Results: The age-standardized incidence was 6. Read More

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May 2018
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Cancer detection rate of prebiopsy MRI with subsequent systematic and targeted biopsy are superior to non-targeting systematic biopsy without MRI in biopsy naïve patients: a retrospective cohort study.

BMC Urol 2018 May 30;18(1):51. Epub 2018 May 30.

Department of Urology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Background: To determine whether prebiopsy multiparametric magnetic resonance imaging (mpMRI) with subsequent systematic plus targeted biopsies for suspicious lesions improve prostate cancer detection compared with standard non-targeting systematic biopsies without mpMRI in biopsy-naïve patients.

Methods: Patients who underwent their first prostate biopsy due to suspicion of prostate cancer were analyzed retrospectively to compare the biopsy outcomes between patients who received prebiopsy mpMRI (215 patients) and those who did not (281 patients). mpMRI was performed to determine pre-biopsy likelihood of the presence of prostate cancer using a three-point scale (1 = low level of suspicion, 2 = equivocal, and 3 = high level of suspicion). Read More

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May 2018
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Decolonization potential of 0.02% polyhexanide irrigation solution in urethral catheters under practice-like in vitro conditions.

BMC Urol 2018 May 24;18(1):49. Epub 2018 May 24.

Department of Research and Development, B. Braun Medical Ltd., Sempach, Switzerland.

Background: Long-term use of indwelling urethral catheters is associated with high risk of urinary tract infection (UTI) and blockage, which may in turn cause significant morbidity and reduce the life of the catheter. A 0.02% polyhexanide irrigation solution has been developed for routine mechanical rinsing together with bacterial decolonization of suprapubic and indwelling urethral catheters. Read More

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May 2018
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Assessment of the use of contrast enhanced ultrasound in guiding microdissection testicular sperm extraction in nonobstructive azoospermia.

BMC Urol 2018 May 23;18(1):48. Epub 2018 May 23.

Department of Andrology, Shanghai General Hospital, Shanghai Jiaotong University, 100 Haining RD, Shanghai, 200080, China.

Background: The aim of this study is to assess the value of contrast-enhanced ultrasound (CEUS) as a new non-invasive approach to locate the testicular area in which spermatogenesis is most likely to be found in non-obstructive azoospermic testes and to evaluate the accuracy of CEUS as a predictor of successful sperm retrieval.

Methods: CEUS was performed in 120 nonobstructive azoospermia (NOA) patients. Microdissection testicular sperm extraction (M-TESE) was performed on the best and poorest perfusion areas selected by CEUS and on conventional areas. Read More

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May 2018
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Site-dependent differences in the composite fibers of male pelvic plexus branches: an immunohistochemical analysis of donated elderly cadavers.

BMC Urol 2018 May 22;18(1):47. Epub 2018 May 22.

Department of Urology, Tottori University Faculty of Medicine, Yonago, Japan.

Background: Although the pelvic autonomic plexus branches are considered to be a mixture of sympathetic and parasympathetic nerves, little is known regarding the composite fibers of the pelvic plexus branches. This study aimed to investigate the immunohistochemical features of sympathetic and parasympathetic nerves in the pelvic autonomic plexus branches.

Methods: Using 10 donated elderly male cadavers, the detailed topohistology of nerve fibers at and around the bladder, seminal vesicle, prostate, and rectum was examined. Read More

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May 2018
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Posterior urethral valves: 10 years audit of epidemiologic, diagnostic and therapeutic aspects in Yaoundé gynaeco-obstetric and paediatric hospital.

BMC Urol 2018 May 21;18(1):46. Epub 2018 May 21.

Departmennt of Surgery and Subspecialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.

Background: The incidence of posterior urethral valve (PUV) is estimated at 1:5000-1:8000 males. It is the most common paediatric urologic urgency and the most common cause of male obstructive uropathy and chronic renal failure in children. The study aimed to describe the experience of Yaoundé gynaeco-obstetrics and paediatric hospital in the management of PUV. Read More

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May 2018
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Risk factors for urinary tract infection in patients with urolithiasis-primary report of a single center cohort.

BMC Urol 2018 May 21;18(1):45. Epub 2018 May 21.

Department of Urology, Urologic Minimally Invasive Treatment Center in Liaoning Province, The Fourth Affiliated Hospital of China Medical University, No4, Chongshan East Road, Shenyang, 110032, China.

Background: Urinary tract infection (UTI) is very common in patients with urolithiasis, which makes the treatment of urolithiasis complicated, even dangerous. The objective of this study was to determine the risk factors for UTI in patients with urolithiasis.

Methods: Eight hundred six patients with urolithiasis were retrospectively evaluated in the fourth affiliated hospital of China Medical University. Read More

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May 2018
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Pre- and intra-operative predictors of postoperative hospital length of stay in patients undergoing radical prostatectomy for prostate cancer in China: a retrospective observational study.

BMC Urol 2018 May 18;18(1):43. Epub 2018 May 18.

Department of Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.

Background: Hospital length of stay (LOS) has recently been receiving increasing attention as a marker of medical resource consumption. Identifying predictors of longer LOS can better equip doctors to counsel patients and facilitate more efficient patient flow and utilization of medical resources. The objective of this study was to identify pre- and intra-operative risk factors for postoperative hospital LOS in patients who had undergone radical prostatectomy in China. Read More

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May 2018
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Adjustable single-incision mini-slings (Ajust®) versus other slings in surgical management of female stress urinary incontinence: a meta-analysis of effectiveness and complications.

BMC Urol 2018 May 18;18(1):44. Epub 2018 May 18.

Department of Urology, School of Medicine Hangzhou, Second Affiliated Hospital, Zhejiang University, No.88 Jiefang Road, Hangzhou, Zhejiang Province, People's Republic of China.

Background: Adjustable single-incision mini-sling (SIMS) is a new category of SIMS for stress urinary incontinence (SUI). The aim of this study was to compare the efficacy and safety of adjustable single-incision mini-sling with other slings.

Methods: Literature search in databases such as Pubmed, and Conchrane Library was performed up to December, 2015. Read More

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May 2018
2 Reads

Obesity impairs male fertility through long-term effects on spermatogenesis.

BMC Urol 2018 May 16;18(1):42. Epub 2018 May 16.

Graduate School of Peking Union Medical College, No. 9 Dongdansantiao, Dongcheng District, Beijing, 100730, People's Republic of China.

Objective: This study aimed to investigate the effect and possible underlying mechanisms of high-fat diet-induced obesity on spermatogenesis in male rats.

Methods: A total of 45 male rats were randomly divided into control (n = 15, normal diet) and obesity groups (n = 30, high-fat diet) and were fed for 16 weeks. Body weight and organ indexes were determined after sacrifice. Read More

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May 2018
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Perioperative outcomes of zero ischemia radiofrequency ablation-assisted tumor enucleation for renal cell carcinoma: results of 182 patients.

BMC Urol 2018 May 15;18(1):41. Epub 2018 May 15.

Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, 321 Zhongshan Rd., Nanjing, 210008, People's Republic of China.

Background: To evaluate the perioperative outcomes of zero ischemia radiofrequency ablation-assisted tumor enucleation.

Methods: Patients undergoing zero ischemia radiofrequency ablation-assisted tumor enucleation were retrospectively identified from July 2008 to March 2013. The tumor was enucleated after RFA treatment. Read More

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Primary synovial sarcoma of the kidney: a case report of complete pathological response at a Lebanese tertiary care center.

BMC Urol 2018 May 11;18(1):40. Epub 2018 May 11.

Department of Internal Medicine, Division of Hematology/Oncology, American University of Beirut - Medical Center, P.o.Box: 11-0236, Riad El Solh, Beirut, 110 72020, Lebanon.

Background: Primary synovial sarcoma of the kidney is a rare type of soft tissue sarcoma. Its presenting features can resemble those of other renal tumors; rendering its early diagnosis, a dilemma. Several cases of renal synovial sarcoma have been reported in the literature with varying treatment options and outcomes. Read More

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Hand-assisted living-donor nephrectomy: a retrospective comparison of two techniques.

BMC Urol 2018 May 10;18(1):39. Epub 2018 May 10.

Division of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland.

Background: Living-donor nephrectomy (LDN) is challenging, as surgery is performed on healthy individuals. Minimally invasive techniques for LDN have become standard in most centers. Nevertheless, numerous techniques have been described with no consensus on which is the superior approach. Read More

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Cost implications of PSA screening differ by age.

BMC Urol 2018 May 9;18(1):38. Epub 2018 May 9.

Department of Medicine, Johns Hopkins University School of Medicine, 2024 E. Monument Street, Suite 2-519, Baltimore, MD, 21287, USA.

Background: Multiple guidelines seek to alter rates of prostate-specific antigen (PSA)-based prostate cancer screening. The costs borne by payers associated with PSA-based screening for men of different age groups-including the costs of screening and subsequent diagnosis, treatment, and adverse events-remain uncertain. We sought to develop a model of PSA costs that could be used by payers and health care systems to inform cost considerations under a range of different scenarios. Read More

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Longitudinal recovery patterns of penile length and the underexplored benefit of long-term phosphodiesterase-5 inhibitor use after radical prostatectomy.

BMC Urol 2018 May 9;18(1):37. Epub 2018 May 9.

Section of Urologic Oncology, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, USA.

Background: Penile length (PL) shortening is an underreported phenomenon following radical prostatectomy (RP) and risk factors are not fully explored. We aimed to describe longitudinal patterns of PL recovery and evaluate factors predicting complete return to baseline PL.

Methods: PL measurement was performed during a preoperative and postoperative follow-up visits at 7 days and 3, 6, 9, and 12 months. Read More

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Reflex erection in the rat: reciprocal interplay between hemodynamic and somatic events.

BMC Urol 2018 May 8;18(1):36. Epub 2018 May 8.

Lomonosov Moscow State University, Biology faculty, 1-12 Leninskie gory, Moscow, 119234, Russia.

Background: Penile erection is a complex reflex under spinal control and modulated by the brain. The hemodynamic events under autonomic control and the perineal muscles somatic activity are interconnected during the reflex erection at the spinal level, however if the afferent feedback on the corpus cavernosum pressure during an erection affects the somatic activity (perineal muscles contractions) and vice versa is not known. This study was aimed to test this hypothesis using a rat model. Read More

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May 2018
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Surgical management of large adrenal tumors: impact of different laparoscopic approaches and resection methods on perioperative and long-term outcomes.

BMC Urol 2018 May 8;18(1):31. Epub 2018 May 8.

Department of Urology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu, 641000, Sichuan, China.

Background: The indication of retroperitoneal laparoscopic adrenalectomy (RLA) was extended with the retroperitoneal approach and has been wildly accepted and technologically matured. However, the management of large adrenal tumors via this approach still remains controversial. The aim of this study was to perform a comprehensive analysis on the minimally invasive surgical management of larger adrenal tumors. Read More

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Efficacy analysis of self-help position therapy after holmium laser lithotripsy via flexible ureteroscopy.

BMC Urol 2018 May 8;18(1):33. Epub 2018 May 8.

Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China.

Background: To observe the efficacy of self-help position therapy (SHPT) after holmium laser lithotripsy via flexible ureteroscopy (FURS).

Methods: From January 2010 to November 2015, 736 nephrolithiasis patients who had received FURS lithotripsy were analyzed retrospectively. In position group, 220 cases accepted SHPT after lithotripsies, and 428 cases as control, coming from another independent inpatient area in the same center. Read More

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May 2018
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Thrombosed varicocele - a rare cause for acute scrotal pain: a case report.

BMC Urol 2018 May 8;18(1):34. Epub 2018 May 8.

Department Of Urology, Apollo Hospitals, Mysore, Karnataka, India.

Background: Acute scrotal pain has various causes. Testicular torsion, torsion of appendages and Epididymo-orchitis are common causes, while varicocele thromboses are a rare cause. Varicocele thromboses can occur post operatively or spontaneously. Read More

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Gastrointestinal cancer and bilateral hydronephrosis resulted in a high risk of ureteral stent failure.

BMC Urol 2018 May 8;18(1):35. Epub 2018 May 8.

Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 2320024, Japan.

Background: Urologists frequently encounter malignant ureteral obstruction (MUO) caused by advanced urological or non-urological malignant disease, but the treatment policy is unclear. The present study examined the risk factors for predicting ureteral stent failure in patients with MUO after ureteral stent insertion and the change in the renal function after retrograde ureteral stent insertion in cases of bilateral hydronephrosis.

Methods: A total of 39 patients who required ureteral stent placement for MUO at Yokohama City University Medical Center (Yokohama, Japan) between February 2007 and May 2016 were included in this study. Read More

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May 2018
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Impact of early changes in serum biomarkers following androgen deprivation therapy on clinical outcomes in metastatic hormone-sensitive prostate cancer.

BMC Urol 2018 May 8;18(1):32. Epub 2018 May 8.

Department of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

Background: Less evidence is known about the role of early changes in serum biomarker after androgen deprivation therapy (ADT) in patients with metastatic hormone-sensitive prostate cancer (mHSPC). Here we evaluated the impact of pre-treatment prognostic factors and early changes in serum biomarkers on prostate specific antigen (PSA) progression-free and overall survival rates in mHSPC.

Methods: We retrospectively reviewed the medical records of 60 mHSPC patients (median age 72 years) treated with ADT whose laboratory data at baseline and following 12 weeks were available. Read More

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Efficacy and safety of PDE5-Is and α-1 blockers for treating lower ureteric stones or LUTS: a meta-analysis of RCTs.

BMC Urol 2018 May 3;18(1):30. Epub 2018 May 3.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: Lower ureteric stones and lower urinary tract symptoms are common in urology.Drug treatment is one of standard therapy,but the efficacy was controversial.Thus we aimed to investigate the efficacy and safety of monotherapy or combination therapy of adrenoceptor1 blockers and phosphodiesterase5 inhibitors for treatment. Read More

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Standardised high dose versus low dose cranberry Proanthocyanidin extracts for the prevention of recurrent urinary tract infection in healthy women [PACCANN]: a double blind randomised controlled trial protocol.

BMC Urol 2018 May 2;18(1):29. Epub 2018 May 2.

Department of Obstetrics and Gynaecology, Laval University, CHU de Québec - Université Laval, 2705, boulevard Laurier, Local A1385, Québec, Québec, G1V 4G2, Canada.

Background: Urinary tract infections (UTIs) are amongst the most common bacterial infections affecting women. Although antibiotics are the treatment of choice for UTI, cranberry derived products have been used for many years to prevent UTIs, with limited evidence as to their efficacy. Our objective is to assess the efficacy of a cranberry extract capsule standardized in A-type linkage proanthocyanidins (PACs) for the prevention of recurrent urinary tract infection. Read More

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Single-stage laparoscopic surgery for bilateral organ tumors using a transumbilical approach with a zigzag incision: a report of two cases.

BMC Urol 2018 May 2;18(1):28. Epub 2018 May 2.

Department of Urology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, 020-8505, Japan.

Background: Reduced port laparoscopic surgery (RPLS) is comparable to conventional multiport laparoscopic surgery and has the potential to provide improved cosmesis and decreased pain; as such, it satisfies a growing demand for less invasive surgical procedures. Moreover, a zigzag incision of the umbilicus results in a less visible scar in plastic surgery. Here we report a series of two cases with bilateral organ tumors treated by single-stage RPLS using a combination of a transumbilical approach and a zigzag incision. Read More

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May 2018
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What predicts emotional response in men awaiting prostate biopsy?

BMC Urol 2018 Apr 24;18(1):27. Epub 2018 Apr 24.

Prostate Cancer Institute, National University of Ireland Galway, Galway, Ireland.

Background: Incidence of prostate cancer is increasing as opportunistic screening becomes widespread and life expectancy rises. Despite screening availability, research reveals conflicting results on medical outcomes, for example, disease specific mortality. However the gold standard in early diagnosis of potentially curable organ confined prostate cancer is transrectal ultrasound-guided systematic prostate biopsy (TRUS-BX). Read More

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Significant response to nivolumab for metastatic chromophobe renal cell carcinoma with sarcomatoid differentiation: a case report.

BMC Urol 2018 Apr 18;18(1):26. Epub 2018 Apr 18.

Department of Urology, Kanagawa Cancer Center, 2-3-2, Nakao, Asahi-ku, Yokohama, Kanagawa, 2418515, Japan.

Background: The treatment of advanced or metastatic renal cell carcinoma (RCC) has drastically changed since the approval of immune checkpoint therapy. Nivolumab is a treatment option for patients with metastatic RCC, previously treated with targeted antiangiogenic therapy. The efficacy of nivolumab for patients with RCC was established by the Checkmate 025 clinical trial. Read More

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April 2018
6 Reads

Role of lymph node dissection in the management of upper tract urothelial carcinomas: a meta-analysis.

BMC Urol 2018 Apr 10;18(1):24. Epub 2018 Apr 10.

Department of Urology, Peking University First Hospital and Institute of Urology, National Research Center for Genitourinary Oncology, Beijing, 100034, China.

Background: Lymph node dissection (LND) is not routinely performed during radical nephroureterectomy (RNU) in upper tract urothelial carcinomas (UTUC) and the role of LND has been controversial. We aim to investigate whether patients with LND had improved survival in UTUC patients.

Methods: We performed a systematic literature search of PubMed, Embase, and Cochrane library for citations published prior to January 2016, describing LND performed among UTUC patients and conducted a standard meta-analysis of survival outcomes. Read More

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April 2018
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Surgical management of urolithiasis - a systematic analysis of available guidelines.

BMC Urol 2018 Apr 10;18(1):25. Epub 2018 Apr 10.

Department of Radiation Oncology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Background: Several societies around the world issue guidelines incorporating the latest evidence. However, even the most commonly cited guidelines of the European Association of Urology (EAU) and the American Urological Association (AUA) leave the clinician with several treatment options and differ on specific points. We aimed to identify discrepancies and areas of consensus between guidelines to give novel insights into areas where low consensus between the guideline panels exists, and therefore where more evidence might increase consensus. Read More

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April 2018
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Comparison of clinicopathologic characteristics, epigenetic biomarkers and prognosis between renal pelvic and ureteral tumors in upper tract urothelial carcinoma.

BMC Urol 2018 Mar 27;18(1):22. Epub 2018 Mar 27.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku St, Xicheng District, Beijing, 100034, China.

Background: There's no consensus about the difference between renal pelvic and ureteral tumors in terms of clinical features, pathological outcomes, epigenetic biomarkers and prognosis.

Methods: The data of 341 patients with renal pelvic tumors and 271 patients with ureteral tumors who underwent radical nephroureterectomy between 1999 and 2011 were retrospectively reviewed. The clinicopathologic features, gene promoters methylation status and oncologic outcomes were compared. Read More

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March 2018
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Triptorelin relieves lower urinary tract symptoms in Chinese advanced prostate cancer patients: a multicenter, non-interventional, prospective study.

BMC Urol 2018 Mar 27;18(1):23. Epub 2018 Mar 27.

Department of Urology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.

Background: Although triptorelin is increasingly used in China for biochemical castration, its effects on primary prostate cancer symptoms remain unclear. This study aimed to assess the prevalence of lower urinary tract symptoms (LUTS) in Chinese prostate cancer patients and the effectiveness of triptorelin on LUTS.

Methods: In this 48-week multicenter, non-interventional, prospective study, we enrolled patients with locally advanced or metastatic prostate cancer. Read More

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March 2018
2 Reads

Fungaemia caused by obstructive renal candida bezoars leads to bilateral chorioretinitis: a case report.

BMC Urol 2018 Mar 16;18(1):21. Epub 2018 Mar 16.

Department of Urology, University of Bonn, Sigmund-Freud-Str. 25, D-53127, Bonn, Germany.

Background: Renal fungal bezoars are remarkably rare and mostly occur in immunodeficient patients. Only a small number of cases with immunocompetent patients have been published so far. The published treatment approaches comprised systemic antimycotic therapy and surgical or minimal invasive removal of the fungal balls. Read More

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March 2018
6 Reads

Prognostic significance of the combination of preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in patients with renal cell carcinoma after nephrectomy.

BMC Urol 2018 Mar 15;18(1):20. Epub 2018 Mar 15.

Department of Urology, Peking University First Hospital, No. 8, Xishiku Street, Xicheng District, Beijing, 100034, China.

Background: To evaluate the prognostic significance of the novel index combining preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in renal cell carcinoma (RCC) patients.

Methods: We enrolled 1360 patients who underwent nephrectomy in our institution from 2001 to 2010. The cutoff values for HALP, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were defined by using X-tile software. Read More

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March 2018
2 Reads

Kidney stone formers have more renal parenchymal crystals than non-stone formers, particularly in the papilla region.

BMC Urol 2018 Mar 12;18(1):19. Epub 2018 Mar 12.

Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.

Background: We investigated the renoprotective ability of healthy people against kidney stone formation. To clarify intratubular crystal kinetics and processing in human kidneys, we performed a quantitative and morphological observation of nephrectomized renal parenchyma tissues.

Methods: Clinical data and pathological samples from 60 patients who underwent radical nephrectomy for renal cancer were collected from June 2004 to June 2010. Read More

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March 2018
1 Read

Clinical utility of a non-invasive urine test for risk assessing patients with no obvious benign cause of hematuria: a physician-patient real world data analysis.

BMC Urol 2018 Mar 9;18(1):18. Epub 2018 Mar 9.

Pacific Edge Limited, 87 St David Street, Dunedin, 9016, New Zealand.

Background: The non-invasive Cxbladder urine test system has demonstrated clinical utility in ruling out urothelial carcinoma (UC) in patients with asymptomatic microscopic hematuria (AMH), suggesting that the number of invasive diagnostic tests, including cystoscopy, used in this patient population may be reduced by Cxbladder testing prior to conducting a full urological work-up. The aim of this study was to demonstrate the enhanced clinical utility of communicating objective information on diagnostic decisions made by individual physicians on individual patients with AMH.

Methods: Three hundred ninety-six physician-patient decisions were generated from twelve participant physicians evaluating real world case notes from the same 33 patients presenting with AMH. Read More

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March 2018
3 Reads

Progressive bladder remodeling due to bladder outlet obstruction: a systematic review of morphological and molecular evidences in humans.

BMC Urol 2018 Mar 9;18(1):15. Epub 2018 Mar 9.

Dipartimento di Medicina Sperimentale e Chirurgia, Università Degli Studi di Roma "Tor Vergata", Roma, Italy.

Background: Bladder outlet obstruction is a common urological condition. We aimed to summarize available evidences about bladder outlet obstruction-induced molecular and morphological alterations occurring in human bladder.

Methods: We performed a literature search up to December 2017 including clinical and preclinical basic research studies on humans. Read More

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March 2018
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Antihypertensive drugs use and the risk of prostate cancer: a meta-analysis of 21 observational studies.

BMC Urol 2018 Mar 7;18(1):17. Epub 2018 Mar 7.

Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.

Background: Due to the lack of strong evidence to identify the relationship between antihypertensive drugs use and the risk of prostate cancer, it was needed to do a systematic review to go into the subject.

Methods: We systematically searched PubMed, Web of Science and Embase to identify studies published, through May 2015. Two evaluators independently reviewed and selected articles involving the subject. Read More

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March 2018
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Mannitol reduces nephron loss after warm renal ischemia in a porcine model.

BMC Urol 2018 Mar 6;18(1):16. Epub 2018 Mar 6.

Urogenital Research Unit, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.

Background: Mannitol has been employed to ameliorate renal warm ischemia damage during partial nephrectomy, however, there is limited scientific evidence to support the use of mannitol during partial nephrectomy. The objective of the present study was to investigate the glomerular number after renal warm ischemia, with and without the use of mannitol in a Pig Model.

Methods: Twenty-four male pigs were assigned into three groups. Read More

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March 2018
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miR-221-5p enhances cell proliferation and metastasis through post-transcriptional regulation of SOCS1 in human prostate cancer.

BMC Urol 2018 Mar 5;18(1):14. Epub 2018 Mar 5.

Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210023, China.

Background: To investigate the effect of miR-221-5p on cell proliferaton and metastasis of human prostate cancer in vitro and vivo.

Methods: We established PC3 cell lines with stable overexpression or silencing of miRNA-221-5p via lentivirus infection. miRNA-221-5p and its target gene SOCS1 expression levels in the stable cells were analyzed by real-time polymerase chain reaction (RT-PCR) and western blotting. Read More

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March 2018
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Ki-67 expression predicts biochemical recurrence after radical prostatectomy in the setting of positive surgical margins.

BMC Urol 2018 Mar 5;18(1):13. Epub 2018 Mar 5.

Division of Urology, Faculty of Medicine, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon.

Background: Positive surgical margin (PSM) is a predictor of biochemical recurrence (BCR) following radical prostatectomy (RP). Attempts to stratify PSM based on linear length, Gleason score, location and number have failed to add to predictive models using margin status alone. We evaluated the prognostic significance of Ki-67 expression in this setting. Read More

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March 2018
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Silodosin 8 mg improves benign prostatic obstruction in Caucasian patients with lower urinary tract symptoms suggestive of benign prostatic enlargement: results from an explorative clinical study.

BMC Urol 2018 Mar 5;18(1):12. Epub 2018 Mar 5.

Department of Neurosciences, Human Reproduction and Odontostomatology, University of Naples, Federico II - Via Pansini 5, 80131, Naples, Italy.

Background: To preliminary investigate the effects of silodosin 8 mg once daily on obstruction urodynamic parameters and subjective symptoms in Caucasian patients with lower urinary tract symptoms suggestive of benign prostatic enlargement.

Methods: We performed a single-center, open-label, single-arm, post-marketing interventional clinical trial. Inclusion criteria were: Caucasian subjects aged ≥50 years waiting to undergo surgery for lower urinary tract symptoms suggestive of benign prostatic enlargement, international prostate symptom total score ≥ 13, international prostate symptom-quality of life score ≥ 3, prostate volume ≥ 30 ml, maximum urine flow rate ≤ 15 mL/s, bladder outlet obstruction index > 40. Read More

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March 2018
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Renal capsule metastasis from renal pelvic cancer: a case report.

BMC Urol 2018 Mar 1;18(1):11. Epub 2018 Mar 1.

Pathology, Kinki Central Hospital of Mutual Aid Association of Public Teachers, 3-1 Kurumazuka, Itami, Hyogo, 664-8533, Japan.

Background: Metastatic renal cancers are relatively common. Most are metastases to the renal parenchyma via a hematogenous route and are derived from lung, breast, and gastrointestinal cancer, malignant melanoma, and hematologic malignant cancer. However, little is known about renal capsule metastasis from other cancers. Read More

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March 2018
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