Functional insights from proteome-wide structural modeling of Treponema pallidum subspecies pallidum, the causative agent of syphilis.
- Simon Houston,
- Karen Vivien Lithgow,
- Kara Krista Osbak,
- Chris Richard Kenyon,
- Caroline E Cameron
BMC Struct Biol 2018 May 16;18(1). Epub 2018 May 16.
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.
Background: Syphilis continues to be a major global health threat with 11 million new infections each year, and a global burden of 36 million cases. The causative agent of syphilis, Treponema pallidum subspecies pallidum, is a highly virulent bacterium, however the molecular mechanisms underlying T. pallidum pathogenesis remain to be definitively identified. Read More