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    Acute cerebellitis in adults: a case report and review of the literature.
    BMC Res Notes 2017 Nov 22;10(1):610. Epub 2017 Nov 22.
    Department of Neurology, Gelre ziekenhuizen Apeldoorn, PO Box 9014, 7300DS, Apeldoorn, The Netherlands.
    Background: Acute cerebellitis is a rare disease with the majority of cases described in children. Little is known about the clinical characteristics and outcome in adults.

    Case Presentation: A 37-year-old Caucasian woman presented with headache, nausea, and photophobia, and was diagnosed as having a migraine attack. Read More

    A preliminary study of cross-amplified microsatellite loci using molted feathers from a near-threatened Painted Stork (Mycteria leucocephala) population of north India as a DNA source.
    BMC Res Notes 2017 Nov 21;10(1):604. Epub 2017 Nov 21.
    Department of Environmental Studies, University of Delhi, Delhi, 110007, India.
    Objective: In continuation of an earlier study in which we reported the cross-amplification of Wood stork microsatellites on the DNA obtained from molted feathers of Painted stork (Mycteria leucocephala), here we investigated the nature of cross-amplified microsatellites and the effect of non-invasive samples on cross-amplification success. In a limited manner, we also addressed the genetic diversity and differentiation in a north Indian population of the Painted Stork examined over three nesting seasons.

    Results: Among the nine cross-amplified loci, only 5 were polymorphic. Read More

    High urinary interleukin-2 in late post-transplant period portends a risk of decline in kidney allograft function: a preliminary study.
    BMC Res Notes 2017 Nov 21;10(1):605. Epub 2017 Nov 21.
    Department of Transplantology and Endocrine Surgery with the Course of Cardiovascular Surgery, State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine", Zaporizhzhia Regional Hospital, 10 Orikhiv highway, Zaporizhzhia, 69050, Ukraine.
    Background: Predictive factors for the rate of decline in kidney allograft function beyond the first post-transplant year have not been thoroughly studied. We aimed to determine whether a single measurement of serum and urinary interleukin 2, interleukin 8 and interleukin 10 at 1-15 years after kidney transplantation could predict a decline in estimated glomerular filtration rate (eGFR) over a 2-year period.

    Results: Greater serum concentrations of interleukin 8 and interleukin 10 in 30 recipients of kidney allograft at enrollment were associated with lower eGFR after 1 year (beta = - 0. Read More

    Timing of first focused antenatal care booking and associated factors among pregnant mothers who attend antenatal care in Central Zone, Tigray, Ethiopia.
    BMC Res Notes 2017 Nov 21;10(1):608. Epub 2017 Nov 21.
    School of Nursing, College of Health Science and Referral Hospital, Aksum University, Aksum, Ethiopia.
    Objective: Focused antenatal care became the recommended type of antenatal care following the publication of a World Health Organization trial on antenatal care where it was discovered that the traditional antenatal care approach do not necessarily improve pregnancy out-come. This study was aimed to assess timing of first focused antenatal care booking and associated factors among pregnant mothers. Facility based cross sectional study was used in the randomly selected health facilities. Read More

    High-throughput SuperSAGE for gene expression analysis of Nicotiana tabacum-Rhizoctonia solani interaction.
    BMC Res Notes 2017 Nov 21;10(1):603. Epub 2017 Nov 21.
    Center for Genetic Engineering and Biotechnology, 10600, Havana, Cuba.
    Objective: The ubiquitous soil pathogen Rhizoctonia solani causes serious diseases in different plant species. Despite the importance of this disease, little is known regarding the molecular basis of susceptibility. SuperSAGE technology and next-generation sequencing were used to generate transcript libraries during the compatible Nicotiana tabacum-R. Read More

    Schistosoma mansoni and other helminthes infections at Haike primary school children, North-East, Ethiopia: a cross-sectional study.
    BMC Res Notes 2017 Nov 21;10(1):609. Epub 2017 Nov 21.
    Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
    Objectives: Schistosomiasis and soil-transmitted helminthes infections are among the widely distributed infections worldwide. In Ethiopia, parasitic helminthic infections and schistosomiasis are among the most predominant causes of outpatient morbidity. Hence there is still lack of epidemiological information in North-Eastern Ethiopia, this study aimed to determine the prevalence and associated factors of Schistosoma mansoni and other helminthes infections at Haike primary school children, Haike, North-East Ethiopia. Read More

    No long-term effect of a 2-days intervention on how to prepare homemade food, on toddlers' skepticism for new food and intake of fruits and vegetables and sweet beverages: a randomized, controlled trial.
    BMC Res Notes 2017 Nov 21;10(1):607. Epub 2017 Nov 21.
    Department of Public Health, Sport and Nutrition, University of Agder, PO 422, 4604, Kristiansand, Norway.
    Objective: Optimal nutrition from early age reduces the risk of developing non-communicable diseases later in life. The aim of this study was to examine the long-term effect on toddlers' fruit and vegetable intake and sweet beverages, and skepticism for new food, of a 2-days' intervention on how to prepare homemade food for toddlers.

    Results: The effect of the cooking intervention was evaluated by a randomized, controlled trial where 110 parents of 4-6 months old infants were included. Read More

    Absence of nuclease activity in commonly used oxygen-scavenging systems.
    BMC Res Notes 2017 Nov 21;10(1):606. Epub 2017 Nov 21.
    Molecular Virology, Department of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.
    Objective: Oxygen scavenging systems are routinely used during single-molecule imaging experiments to improve fluorescent dye stability. Previous work has shown nuclease contamination in the commonly used oxygen scavenging systems. This study evaluates the potential for nuclease contamination in these oxygen scavenging systems. Read More

    Calpain-5 gene expression in the mouse eye and brain.
    BMC Res Notes 2017 Nov 21;10(1):602. Epub 2017 Nov 21.
    Omics Laboratory, Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, 94304, USA.
    Objective: Our objective was to characterize CAPN5 gene expression in the mouse central nervous system. Mouse brain and eye sections were probed with two high-affinity RNA oligonucleotide analogs designed to bind CAPN5 RNA and one scramble, control oligonucleotide. Images were captured in brightfield. Read More

    Evaluation of the effect of a floxed Neo cassette within the dystroglycan (Dag1) gene.
    BMC Res Notes 2017 Nov 21;10(1):601. Epub 2017 Nov 21.
    Istituto di Chimica del Riconoscimento Molecolare (CNR), c/o Università Cattolica del Sacro Cuore, Rome, Italy.
    Objective: Dystroglycan (DG) is an adhesion complex formed by two subunits, α-DG and β-DG. In skeletal muscle, DG is part of the dystrophin-glycoprotein complex that is crucial for sarcolemma stability and it is involved in a plethora of muscular dystrophy phenotypes. Due to the important role played by DG in skeletal muscle stability as well as in a wide variety of other tissues including brain and the peripheral nervous system, it is essential to investigate its genetic assembly and transcriptional regulation. Read More

    The analysis of novel microRNA mimic sequences in cancer cells reveals lack of specificity in stem-loop RT-qPCR-based microRNA detection.
    BMC Res Notes 2017 Nov 17;10(1):600. Epub 2017 Nov 17.
    Asbestos Diseases Research Institute, Sydney, NSW, 2139, Australia.
    Objective: MicroRNAs are frequently downregulated in cancer, and restoring expression has tumour suppressive activity in tumour cells. Our recent phase I clinical trial investigated microRNA-based therapy in patients with malignant pleural mesothelioma. Treatment with TargomiRs, microRNA mimics with novel sequence packaged in EGFR antibody-targeted bacterial minicells, revealed clear signs of clinical activity. Read More

    Self-reported actual and desired proportion of sitting, standing, walking and physically demanding tasks of office employees in the workplace setting: do they fit together?
    BMC Res Notes 2017 Nov 17;10(1):504. Epub 2017 Nov 17.
    Institute of Health Promotion and Clinical Movement Science, German Sport University Cologne, Cologne, Germany.
    Objective: Occupational sitting time in white-collar workers represents a prominent contributor to overall daily sitting time, which is associated with various health risks. Workplace interventions intending to reduce sitting time during work typically focus on replacing sitting with standing. The aim was to investigate and compare actual and desired proportions of time spent sitting, standing, walking, and doing physically demanding tasks at work reported by desk-based workers. Read More

    Multiple small hemorrhagic infarcts in cerebral air embolism: a case report.
    BMC Res Notes 2017 Nov 16;10(1):599. Epub 2017 Nov 16.
    Department of Neurology, Kobe City Medical Center General Hospital, Hyogo, Japan.
    Background: Cerebral air embolism is a rare cause of cerebral infarction. In cerebral air embolism, T2 star-weighted imaging shows numerous spotty hypointense signals. Previous reports have suggested that these signals represent air in the brain and are gradually diminished and absorbed. Read More

    Bacillus anthracis gamma phage lysis among soil bacteria: an update on test specificity.
    BMC Res Notes 2017 Nov 16;10(1):598. Epub 2017 Nov 16.
    Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.
    Background: Bacillus anthracis, which causes anthrax in humans and animals, is enzootic in parts of the U.S. state of Texas where cases are typically reported in animals annually. Read More

    Glycemic control and associated factors among type 2 diabetic patients at Shanan Gibe Hospital, Southwest Ethiopia.
    BMC Res Notes 2017 Nov 15;10(1):597. Epub 2017 Nov 15.
    Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
    Objective: The aim of this study was to assess the rate of glycemic control and factors affecting glycemic control in type 2 diabetic patients.

    Results: A total of 174 type 2 diabetic patients were interviewed and were studied. Mean age of the patients was 48. Read More

    Peer assisted learning among Sri Lankan medical undergraduates: a cross sectional study.
    BMC Res Notes 2017 Nov 14;10(1):595. Epub 2017 Nov 14.
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08, Sri Lanka.
    Objective: The objectives of this study were to; (a) evaluate the current practices of peer assisted learning among second year and final year medical students of Faculty of Medicine, University of Colombo, Sri Lanka; (b) identify reasons for engaging in peer assisted learning; (c) identify perceived weaknesses in current learning activities; and (d) determine student characteristics associated with engaging in peer assisted learning.

    Results: This cross sectional study interviewed two hundred and eighty-four eligible students. Average number of hours spent on peer assisted learning during a week was significantly greater among second year students compared to final year students (15. Read More

    How Brunei trainee teachers cope with distress: counseling implications.
    BMC Res Notes 2017 Nov 14;10(1):596. Epub 2017 Nov 14.
    Psychological Studies and Human Development Academic Group, Sultan Hassanal Bolkiah Institute of Education, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, Bandar Seri Begawan, BE 1410, Brunei Darussalam.
    Objective: This study investigated the strategies used by student teachers when dealing with distress during training. Specifically, this study addressed the following research goals: (1) identify Ways of Coping that predict achievement on a quantitative reasoning test; (2) determine participants' coping differences per sex, age, and ability in quantitative reasoning; and (3) reveal coping strategies that work best for each and both sexes in fostering academic achievement in quantitative reasoning. The data used in this study was from a single observation. Read More

    The proportion of the population of England that self-identifies as lesbian, gay or bisexual: producing modelled estimates based on national social surveys.
    BMC Res Notes 2017 Nov 13;10(1):594. Epub 2017 Nov 13.
    Clinical Trial and Population Studies Department, Plymouth University Peninsula Schools of Medicine and Dentistry, 1 Davy Road, Plymouth, PL6 8BX, UK.
    Objectives: There is currently no widely accepted estimate of the proportion of people in England that self-identifies as lesbian, gay or bisexual (LGB), which is needed if we are to compare health inequality between different population groups. Using systematic review methods, this study identified all national social surveys with a question on sexual orientation and pooled those which represented the overall population of England. LGB proportions were synthesized into an aggregated mean estimate using weights based on sample size, response rate and missing data. Read More

    Indoor air pollution from secondhand tobacco smoke, solid fuels, and kerosene in homes with active tuberculosis disease in South Africa.
    BMC Res Notes 2017 Nov 13;10(1):591. Epub 2017 Nov 13.
    Department of Health North West Province, Department of Internal Medicine, Klerksdorp Tshepong Hospital Complex, Matlosana, 2574, South Africa.
    Objectives: Secondhand tobacco smoke (SHS), use of solid fuels, and kerosene may play an important role in perpetuating the tuberculosis (TB) epidemic. The purpose of this study was to explore the prevalence of household air pollution (HAP) from these sources in homes of someone with TB in a high HIV-prevalence setting. A convenience sample of homes and household members participating in an ongoing active case-finding study in Matlosana district townships surrounding Klerksdorp, South Africa were included. Read More

    Quantifying mitochondrial DNA copy number using robust regression to interpret real time PCR results.
    BMC Res Notes 2017 Nov 13;10(1):593. Epub 2017 Nov 13.
    Department of Tumor Biology, Radiumhospital, 0379, Oslo, Norway.
    Background: Real time PCR (rtPCR) is a quantitative assay to determine the relative DNA copy number in a sample versus a reference. The [Formula: see text] method is the standard for the analysis of the output data generated by an rtPCR experiment. We developed an alternative based on fitting a robust regression to the rtPCR signal. Read More

    Frequency and determinants for hemorrhagic transformation of posterior cerebral stroke : Posterior ischemic stroke and hemorrhagic transformation.
    BMC Res Notes 2017 Nov 13;10(1):592. Epub 2017 Nov 13.
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche (BioNeC), Università degli Studi di Palermo, Via Gaetano La Loggia 1, 90129, Palermo, Italy.
    Background: hemorrhagic transformation is a threatening ischemic stroke complication. Frequency of hemorrhagic transformation differs greatly among studies, and its risk factors have been usually studied in patients with anterior ischemic stroke who received thrombolytic therapy. We evaluated, in a hospital-based series of patients with posterior ischemic stroke not treated with thrombolysis, frequency and risk factors of hemorrhagic transformation. Read More

    Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: findings from a cross-sectional study.
    BMC Res Notes 2017 Nov 10;10(1):589. Epub 2017 Nov 10.
    Service des Maladies Infectieuses et Médecine Interne Générale, Centre Hospitalier et Universitaire de Liège, Liège, Belgium.
    Background: The national antiretroviral therapy in the Republic of Chad provides free of charge antiretroviral regimens and therapeutic monitoring for patients receiving antiretroviral therapy nationwide. For a successful programmatic uptake, these efforts merit to be supported by thorough assessments of antiretroviral therapy response and HIV-1 drug resistance surveillance, especially with risks of cross-resistance due to the gradual stavudine phasing out in such national settings. We therefore evaluated the virological response to antiretroviral therapy, HIV-1 drug resistance emergence and circulating HIV-1 clades in a Chad context. Read More

    Artificial neural networks to predict future bone mineral density and bone loss rate in Japanese postmenopausal women.
    BMC Res Notes 2017 Nov 10;10(1):590. Epub 2017 Nov 10.
    Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, 113-8655, Japan.
    Objective: Predictions of the future bone mineral density and bone loss rate are important to tailor medicine for women with osteoporosis, because of the possible presence of personal risk factors affecting the severity of osteoporosis in the future. We investigated whether it was possible to predict bone mineral density and bone loss rate in the future using artificial neural networks.

    Results: A total of 135 women over 50 years old residing in T town of Wakayama Prefecture, Japan were analyzed to establish a statistical model. Read More

    Development of a peer-supported, self-management intervention for people following mental health crisis.
    BMC Res Notes 2017 Nov 9;10(1):588. Epub 2017 Nov 9.
    Division of Psychiatry, University College London, 6th Floor, Maple House, 149 Tottenham Court Road, London, W1T 7NF, UK.
    Background: A documented gap in support exists for service users following discharge from acute mental health services, and structured interventions to reduce relapse are rarely provided. Peer-facilitated self-management interventions have potential to meet this need, but evidence for their effectiveness is limited. This paper describes the development of a peer-provided self-management intervention for mental health service users following discharge from crisis resolution teams (CRTs). Read More

    A foot-care program to facilitate self-care by the elderly: a non-randomized intervention study.
    BMC Res Notes 2017 Nov 9;10(1):586. Epub 2017 Nov 9.
    Faculty of Health Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, 920-0942, Japan.
    Objective: We aimed to evaluate a foot-care awareness program designed to improve foot morphology, physical functioning, and fall prevention among the community-dwelling elderly. Eleven independent community-dwelling elderly women (aged 61-83 years) were provided with foot-care advice and shown effective foot-care techniques to perform regularly for 6 months, and compared with a control group of 10 elderly women who did not receive any intervention. Measurements of foot form, functional capacity, subjective foot movement, and physical function were taken at baseline and 6-month follow-up. Read More

    Improving adherence in mental health service users with severe mental illness in South Africa: a pilot randomized controlled trial of a treatment partner and text message intervention vs. treatment as usual.
    BMC Res Notes 2017 Nov 9;10(1):584. Epub 2017 Nov 9.
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
    Objectives: Medication non-adherence is a significant problem in treatment of severe mental disorders and is associated with poor clinical outcomes and increased demand on services. Task-shifting interventions incorporating mobile health may improve adherence in mental health service users in low- and middle-income countries. Seventy-seven participants were recruited from a psychiatric hospital in Cape Town, with 42 randomized to receive the intervention and 35 to treatment as usual. Read More

    Family planning need of people living with HIV/AIDS in antiretroviral therapy clinics of Horro Guduru Wollega zone, Ethiopia.
    BMC Res Notes 2017 Nov 9;10(1):581. Epub 2017 Nov 9.
    Department of Nursing and Midwifery, College of Health Sciences, Wollega University, P.O. Box 395, Nekemte, Ethiopia.
    Objective: The purpose of this study was to identify factors associated with family planning needs among people living with human immunodeficiency virus (HIV) in Ethiopia.

    Results: Three hundred twenty-one participants provided information on family planning methods and associated factors. Forty-six-point four percent of respondents reported using at least one form of family planning method; injectables (50. Read More

    Round cell sarcoma of the colon with CIC rearrangement.
    BMC Res Notes 2017 Nov 9;10(1):582. Epub 2017 Nov 9.
    Oncology Unit, Institut Salah Azaiez Tunis, Tunis, Tunisia.
    Background: The CIC-rearranged sarcoma is a very rare highly aggressive malignant soft tissue group of tumors. It has recently been described as highly aggressive soft tissue tumors of children and young adults sharing similar morphological features with the Ewing sarcoma. The digestive localization is exceptional. Read More

    Dyslipidaemia in a Black African diabetic population: burden, pattern and predictors.
    BMC Res Notes 2017 Nov 9;10(1):587. Epub 2017 Nov 9.
    Department of Medicine, Uganda Martyrs Hospital Lubaga, P.O. BOX 7146, Kampala, Uganda.
    Objectives: This study sought to assess the burden, pattern and predictors of dyslipidaemia in 425 adult diabetic patients in Uganda.

    Results: The median (IQR) age of the study participants was 53 (43.5-62) years with a female majority (283, 66. Read More

    Application of ultrasound imaging biomarkers (HistoScanning™) improves staging reliability of prostate biopsies.
    BMC Res Notes 2017 Nov 9;10(1):579. Epub 2017 Nov 9.
    Department of Urology and Pediatric Urology, University Hospital Schleswig-Holstein, UKSH, Campus Kiel, Arnold Heller Strasse 3, 24105, Kiel, Germany.
    Objective: Imaging biomarkers like HistoScanning™ augment the informative value of ultrasound. Analogue image-guidance might improve the diagnostic accuracy of prostate biopsies and reduce misclassifications in preoperative staging and grading.

    Results: Comparison of 77 image-guided versus 88 systematic prostate biopsies revealed that incorrect staging and Gleason misclassification occurs less frequently in image-guided than in systematic prostate biopsies. Read More

    Intrinsic DNA curvature in trypanosomes.
    BMC Res Notes 2017 Nov 9;10(1):585. Epub 2017 Nov 9.
    Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la Republica, 11400, Montevideo, Uruguay.
    Background: Trypanosoma cruzi and Trypanosoma brucei are protozoan parasites causing Chagas disease and African sleeping sickness, displaying unique features of cellular and molecular biology. Remarkably, no canonical signals for RNA polymerase II promoters, which drive protein coding genes transcription, have been identified so far. The secondary structure of DNA has long been recognized as a signal in biological processes and more recently, its involvement in transcription initiation in Leishmania was proposed. Read More

    A complicated prosthetic valve endocarditis due to methicillin resistant Staphylococci treated with linezolid and ciprofloxacin: a case report.
    BMC Res Notes 2017 Nov 9;10(1):580. Epub 2017 Nov 9.
    Teaching Hospital, Kandy, Sri Lanka.
    Background: Prosthetic valve endocarditis (PVE) due to methicillin resistant Staphylococcus aureus (MRSA) is a rare disease with significant mortality and morbidity. With the emerging resistance and adverse effect profile of vancomycin which is the standard treatment, there is a compelling necessity of an effective alternative for vancomycin. Linezolid is proved as such an agent for infections caused by MRSA in other sites. Read More

    Coinfection of intestinal schistosomiasis and malaria and association with haemoglobin levels and nutritional status in school children in Mara region, Northwestern Tanzania: a cross-sectional exploratory study.
    BMC Res Notes 2017 Nov 9;10(1):583. Epub 2017 Nov 9.
    Department of Disease Control and Environmental Health, School of Public Health, Makerere University, P. O. Box 7072, Kampala, Uganda.
    Background: Schistosomiasis represents a major public health problem in Tanzania despite ongoing national control efforts. This study examined whether intestinal schistosomiasis is associated with malaria and assessed the contribution of intestinal schistosomiasis and malaria on anaemia and undernutrition in school children in Mara region, North-western Tanzania.

    Methods: Stool samples were collected from each of 928 school children randomly selected from 5 schools and examined for intestinal schistosomiasis using the Kato Katz method. Read More

    Management of X-linked adrenoleukodystrophy in Morocco: actual situation.
    BMC Res Notes 2017 Nov 7;10(1):567. Epub 2017 Nov 7.
    Biochemistry Laboratory, Faculty of Medicine and Pharmacy, University Mohammed V Souissi, Rabat, Morocco.
    Objectives: X-linked adrenoleukodystrophy is a neurodegenerative disorder caused by mutations in the ABCD1 gene. Adrenomyeloneuropathy and childhood cerebral Adrenoleukodystrophy are the most common phenotypes. This paper focuses on a descriptive study of the first program of diagnosis, treatment, and follow-up of this disease in Morocco. Read More

    Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease.
    BMC Res Notes 2017 Nov 7;10(1):573. Epub 2017 Nov 7.
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
    Objective: Gain-of-function (GOF) mutations in RHBDF2 cause tylosis. Patients present with hyperproliferative skin, and keratinocytes from tylosis patients' skin show an enhanced wound-healing phenotype. The curly bare mouse model of tylosis, carrying a GOF mutation in the Rhbdf2 gene (Rhbdf2 (cub) ), presents with epidermal hyperplasia and shows accelerated cutaneous wound-healing phenotype through enhanced secretion of the epidermal growth factor receptor family ligand amphiregulin. Read More

    Multi-drug resistance and extended spectrum beta lactamase producing Gram negative bacteria from chicken meat in Bharatpur Metropolitan, Nepal.
    BMC Res Notes 2017 Nov 7;10(1):574. Epub 2017 Nov 7.
    Department of Microbiology, Prithu Technical College, Institute of Agriculture and Animal Science, Tribhuvan University, Dang, Nepal.
    Objective: Multidrug resistance (MDR) and extended spectrum beta lactamase (ESBL) producer Gram negative bacteria are considered as a major health problem, globally. ESBL enzyme hydrolyses the beta lactam ring of third generation cephalosporins, which alters the structure of the antibiotic. Due to the modification in structure of the antibiotic, bacteria show resistance to these antibiotics. Read More

    Prevalence and determinants of pulmonary hypertension in a group of Cameroonian patients without chronic lung disease: a cross-sectional echocardiographic study.
    BMC Res Notes 2017 Nov 7;10(1):571. Epub 2017 Nov 7.
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
    Objective: To study prevalence and determinants of pulmonary hypertension (PH) in a group of Cameroonian patients without chronic lung disease. We conducted a cross-sectional study conducted between April and December 2011 in a private cardiology clinic in Bafoussam, Cameroon. We included consenting participants aged ≥ 18, who underwent a Doppler echocardiography. Read More

    Use of tuberculin skin test for assessment of immune recovery among previously malnourished children in Ethiopia.
    BMC Res Notes 2017 Nov 7;10(1):570. Epub 2017 Nov 7.
    Department of Paediatrics and Child Health, Jimma University, Jimma, Oromia, Ethiopia.
    Objective: To compare levels of immunity in children recovering from severe acute malnutrition (cases) against those of community controls (controls).

    Results: At baseline children recovering from severe acute malnutrition had lower, mid upper arm circumference (122 mm for cases and 135 mm for controls; p < 0.001), weight-for-height Z-score (- 1. Read More

    Body mass index and thoracic subcutaneous adipose tissue depth: possible implications for adequacy of chest compressions.
    BMC Res Notes 2017 Nov 7;10(1):575. Epub 2017 Nov 7.
    Emergency and Retrieval Medicine Consultant, Retrieval Medicine, Alice Springs Hospital, Gap Road Alice Springs, Alice Springs, Northern Territory, Australia.
    Objective: Adequacy of cardiopulmonary resuscitation relies on compression of the thoracic cage to produce changes in intra-thoracic pressures sufficient to generate a pressure gradient. In order to evaluate the efficacy of cardiopulmonary resuscitation in morbid obesity, it is first necessary to determine the depth of thoracic subcutaneous adipose tissue (SAT) and to correlate this with body mass index (BMI).

    Results: Computerised-tomography images of the thorax of 55 patients with a diagnosis of obesity or morbid obesity (mean BMI 45. Read More

    Genetic model misspecification in genetic association studies.
    BMC Res Notes 2017 Nov 7;10(1):569. Epub 2017 Nov 7.
    Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, Social Epidemiology Research Unit, National Institutes of Health, National Human Genome Research Institute, Bethesda, USA.
    Objective: The underlying model of the genetic determinant of a trait is generally not known with certainty a priori. Hence, in genetic association studies, a dominant model might be erroneously modelled as additive, an error investigated previously. We explored this question, for candidate gene studies, by evaluating the sample size required to compensate for the misspecification and improve inference at the analysis stage. Read More

    Phage typing or CRISPR typing for epidemiological surveillance of Salmonella Typhimurium?
    BMC Res Notes 2017 Nov 7;10(1):578. Epub 2017 Nov 7.
    Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK.
    Objective: Salmonella Typhimurium is the most dominant Salmonella serovar around the world. It is associated with foodborne gastroenteritis outbreaks but has recently been associated with invasive illness and deaths. Characterization of S. Read More

    Hyperuricemia in type 2 diabetic model KK-A(y)/Ta mice: a potent animal model with positive correlation between insulin resistance and plasma high uric acid levels.
    BMC Res Notes 2017 Nov 7;10(1):577. Epub 2017 Nov 7.
    Center for Bioscience Research and Education, Utsunomiya University, Mine-machi 350, Utsunomiya, Tochigi, 321-8505, Japan.
    Objective: Hyperuricemia is recognized as a main cause of gout. Accumulating clinical evidence suggests that hyperuricemia is strongly associated with insulin resistance and abnormal glucose metabolism. However, there seem no proper animal models for investigating such associations. Read More

    Anal incontinence and quality of life following operative treatment of simple cryptoglandular fistula-in-ano: a prospective study.
    BMC Res Notes 2017 Nov 7;10(1):572. Epub 2017 Nov 7.
    Department of Surgery, Faculty of Medicine, University of Colombo, Kynsey Road, P. O. Box 271, Colombo 8, Sri Lanka.
    Background: Anal incontinence is a known complication following operative treatment of fistula-in-ano which can significantly impact the quality of life. This study was aimed to objectively assess the impact of operative treatment of simple fistula-in-ano on quality of life related to anal incontinence. Therefore, a prospective study was conducted in 34 patients who underwent surgery for fistula-in-ano over a period of 24 months. Read More

    Common oral conditions and correlates: an oral health survey in Kwara State Nigeria.
    BMC Res Notes 2017 Nov 7;10(1):568. Epub 2017 Nov 7.
    Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine University of Ibadan, Ibadan, Nigeria.
    Background: Oral diseases are one of the most prevalent health problems today with distribution and severity varying in different parts of the world and within the same country. Oral health surveys are needed to determine prevalence of oral conditions and the nature and urgency of oral health interventions. A modified version of World Health Organisation pathfinder survey methods was used to determine prevalence of oral conditions amongst 150 respondents in two local government areas in Kwara State, Nigeria. Read More

    PVL overexpression due to genomic rearrangements and mutations in the S. aureus reference strain ATCC25923.
    BMC Res Notes 2017 Nov 7;10(1):576. Epub 2017 Nov 7.
    Alere Technologies GmbH (Abbott Rapid Diagnostics), Jena, Germany.
    Objective: ATCC25923 is a Staphylococcus aureus strain that is positive for the Panton Valentin leukocidin. It has been used for decades as reference strain. We observed that two separately maintained clones of ATCC25923 ("G477 and G478") differed grossly in the expression of this toxin. Read More

    A microdeletion in the GRHL2 Gene in two unrelated patients with congenital fibrosis of the extra ocular muscles.
    BMC Res Notes 2017 Nov 6;10(1):562. Epub 2017 Nov 6.
    Division of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
    Objective: Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is known to be caused by mutations in KIF21A or TUBB3 or other known genes (SALL4, CHN1, HOXA1). However, affected children may harbor other genetic defects. Therefore, a candidate gene analysis (KIF21A, TUBB3 SALL4, CHN1, HOXA1) and a high-resolution array comparative genomic hybridization (arrayCGH) was performed in two unrelated children with sporadic CFEOM1. Read More

    Development of interstitial pneumonia during treatment with eribulin: a case report.
    BMC Res Notes 2017 Nov 6;10(1):557. Epub 2017 Nov 6.
    Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.
    Background: Eribulin is typically used to treat patients with advanced breast cancer, and anti-cancer agents often cause the development of interstitial pneumonia in Japanese patients with advanced cancer. However, few case reports have addressed eribulin-induced interstitial pneumonia. Herein, we report a rare case of interstitial pneumonia-specifically, organized pneumonia-during treatment with eribulin in a patient with advanced breast cancer. Read More

    Level of asthma control and risk factors for poor asthma control among clinic patients seen at a Referral Hospital in Addis Ababa, Ethiopia.
    BMC Res Notes 2017 Nov 6;10(1):558. Epub 2017 Nov 6.
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University, College of Physicians and Surgeons, New York, NY, USA.
    Objective: Uncontrolled asthma negatively impacts patients, families, and the community. The level of symptom control among asthmatics in Ethiopia has not been well studied. We investigated the level of asthma control and risk factors for poor asthma control in clinic patients seen in the largest public hospital in Ethiopia. Read More

    Penile metastasis from rectal adenocarcinoma: a case report.
    BMC Res Notes 2017 Nov 6;10(1):564. Epub 2017 Nov 6.
    Department of Pathology, Hassan II University Hospital, Fès, Morocco.
    Background: Despite its rich vasculature, the penis is rarely involved by metastasis. Since the first description of penile metastasis in 1870, fewer than 500 cases have been reported in the literature. The pelvic organs are the main source of primary tumors that metastasize to the penis. Read More

    Prevalence of markers of HIV infection among febrile adults and children in Bo, Sierra Leone, 2012-2013.
    BMC Res Notes 2017 Nov 6;10(1):565. Epub 2017 Nov 6.
    Center for Biomolecular Science & Engineering, U.S. Naval Research Laboratory, Washington, DC, USA.
    Objective: The goal of this study was to examine the prevalence of HIV among febrile patients seeking care in Mercy Hospital, Bo, Sierra Leone, in 2012-2013.

    Results: A total of 1207 febrile persons were tested for HIV with Determine™ and SD Bioline rapid diagnostic tests kits that detect the presence of HIV antibodies and HIV p24 antigens. The overall prevalence of HIV among the tested patients was 8. Read More

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