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    Effect of propranolol on heart rate variability in hyperthyroidism.
    BMC Res Notes 2018 Feb 22;11(1):151. Epub 2018 Feb 22.
    National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon.
    Objectives: We aimed to determine the effect of propanolol on heart rate variability (HRV) in hyperthyroidism before antithyroid treatment. This was a before and after study, on ten patients presenting overt hyperthyroidism naïve to treatment. In each patient, a resting electrocardiogram was done followed by estimation of cardiac autonomic dysfunction during five maneuvers (Ewing battery tests). Read More

    miRCancerdb: a database for correlation analysis between microRNA and gene expression in cancer.
    BMC Res Notes 2018 Feb 7;11(1):103. Epub 2018 Feb 7.
    Department of Biochemistry and Convergence Medical Sciences and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, 527-27, Republic of Korea.
    Objectives: microRNAs regulate expression of target genes by specifically binding to their transcripts, subsequently leading to translational inhibition or mRNA degradation. Gene regulation by microRNAs has been implicated in a wide range of physiological and pathological conditions. Here, we leverage the use of public-access data and the available genomic annotations to pre-calculate the correlation of the expression of a large number of microRNAs with gene at the mRNA and protein level in the context of cancers. Read More

    Pegylated and liposomal doxorubicin is associated with high mortality and causes limited cardiotoxicity in mice.
    BMC Res Notes 2018 Feb 21;11(1):148. Epub 2018 Feb 21.
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
    Objective: We wanted to determine the impact of different doses of a pegylated and liposomal formulation of the cardiotoxic drug doxorubicin on cardiac function, fibrosis and survival in mice. The drug causes myocardial damage by producing reactive oxygen species, mitochondrial damage and lipid peroxidation. Thymosin beta 4 is a peptide with cardioprotective, anti-oxidant and anti-fibrotic properties and we further investigated whether the peptide could attenuate this drug-induced injury by measuring cardiac function and fibrosis. Read More

    Assessment of communication technology and post-operative telephone surveillance during global urology mission.
    BMC Res Notes 2018 Feb 21;11(1):149. Epub 2018 Feb 21.
    Virginia Urology, Richmond, Virginia, USA.
    Objective: Compliance with post-operative follow-up in the context of international surgical trips is often poor. The etiology of this problem is multifactorial and includes lack of local physician involvement, transportation costs, and work responsibilities. We aimed to better understand availability of communication technologies within Belize and use this information to improve follow-up after visiting surgical trips to a public hospital in Belize City. Read More

    Diurnal variation of NMDA receptor expression in the rat cerebral cortex is associated with traumatic brain injury damage.
    BMC Res Notes 2018 Feb 21;11(1):150. Epub 2018 Feb 21.
    Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.
    Objective: Data from our laboratory suggest that recovery from a traumatic brain injury depends on the time of day at which it occurred. In this study, we examined whether traumatic brain injury -induced damage is related to circadian variation in N-methyl-D-aspartate receptor expression in rat cortex.

    Results: We confirmed that traumatic brain injury recovery depended on the time of day at which the damage occurred. Read More

    Adherence to the face-down positioning after vitrectomy and gas tamponade: a time series analysis.
    BMC Res Notes 2018 Feb 20;11(1):142. Epub 2018 Feb 20.
    Department of Ophthalmology, Fujita Health University School of Medicine, Fujita Health University Hospital, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
    Objective: To determine the adherence to the face-down positioning (FDP) in 296 patients who had undergone vitrectomy and gas tamponade.

    Results: We studied 119 female and 177 male patients who had undergone primary vitrectomy and gas tamponade for a macular hole (MH) or for rhegmatogenous retinal detachments (RRDs). Adherence was assessed and recorded four times per day for 3 days postsurgery. Read More

    Increased attachment security is related to early therapy drop-out in substance use disorders.
    BMC Res Notes 2018 Feb 20;11(1):141. Epub 2018 Feb 20.
    Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, Graz, Austria.
    Objectives: Previous research work suggests a positive association between secure attachment and increased therapy adherence (TA) in different patient groups. However, there is still a strong need for research focusing on the influence of attachment on TA in substance use disorder (SUD) treatment. Hence, this study attempts to investigate the predictive value of different attachment patterns concerning TA in SUD inpatients. Read More

    Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity.
    BMC Res Notes 2018 Feb 20;11(1):138. Epub 2018 Feb 20.
    Department of Pediatrics, Université Laval, CHUL, 2705 Boul. Laurier, RC-9800, Quebec, QC, G1V 4G2, Canada.
    Objective: The Hairy Enhancer of Split 1 (HES1) is a transcriptional repressor that regulates cellular proliferation and differentiation during development. We previously found an interaction between HES1 and Fanconi anemia (FA) proteins. FA is a hematological and developmental disorder caused by mutations in more than 20 different genes. Read More

    Schistosoma mansoni and other intestinal parasitic infections in schoolchildren and vervet monkeys in Lake Ziway area, Ethiopia.
    BMC Res Notes 2018 Feb 20;11(1):146. Epub 2018 Feb 20.
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
    Objective: To assess Schistosoma mansoni and other intestinal parasitic infections in schoolchildren and vervet monkeys (Chlorocebus aethiops) in Bochessa Village, Ziway, Ethiopia.

    Results: Fecal specimens from selected schoolchildren and droppings of the vervet monkeys were collected and microscopically examined for intestinal parasites using the Kato-Katz thick smear and formol-ether concentration techniques. The prevalences of S. Read More

    Development and evaluation of 16 new microsatellite loci for the rock ptarmigan (Lagopus muta) and cross-species amplification for the willow grouse (L. lagopus).
    BMC Res Notes 2018 Feb 20;11(1):147. Epub 2018 Feb 20.
    Department of Natural Sciences and Environmental Health, University College of Southeast Norway, Gullbringvegen 36, 3800, Bø i Telemark, Norway.
    Objective: The genetic markers designed for this study can facilitate future genetic studies on the rock ptarmigan (Lagopus muta). To our knowledge no microsatellite markers have ever been developed specifically for this species before. These new microsatellite markers will be useful for population genetics studies and for future conservation projects. Read More

    Molecular detection of colistin resistance genes (mcr-1 to mcr-5) in human vaginal swabs.
    BMC Res Notes 2018 Feb 20;11(1):143. Epub 2018 Feb 20.
    College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
    Objective: Colistin resistance has emerged worldwide and has been threatening the efficacy of one of the last-resort antimicrobials used for treatment of multidrug resistant Gram-negative bacteria. While five colistin resistance genes (mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5) have been described, few data are available on the prevalence of mcr-genes other than mcr-1 in human samples.

    Results: In this study, the presence of five currently described colistin resistance genes (mcr 1-5) in vaginal swabs of women undergoing infertility evaluation was reported. Read More

    Risk factors associated with precancerous cervical lesion among women screened at Marie Stops Ethiopia, Adama town, Ethiopia 2017: a case control study.
    BMC Res Notes 2018 Feb 20;11(1):145. Epub 2018 Feb 20.
    Department of Nursing and Midwifery, School of Allied Health Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
    Objective: Although cervical cancer is a preventable disease, it remains a leading cause of death among women in developing countries. In this unmatched case control design, 55 cases and 109 controls were included. The main objective of this study was to assess the risk factors of precancerous cervical lesion in Adama town. Read More

    Co-infection of intestinal parasites and Helicobacter pylori among upper gastrointestinal symptomatic adult patients attending Mekanesalem Hospital, northeast Ethiopia.
    BMC Res Notes 2018 Feb 20;11(1):144. Epub 2018 Feb 20.
    , Po. Box 1145, Dessie, Ethiopia.
    Objective: Intestinal parasites and H. pylori are well-known for their high prevalence worldwide. Thus, the objective of this study waste assess risk factors and co-infection of intestinal parasites and H. Read More

    Agreement of self- and physician-collected samples for detection of high-risk human papillomavirus infections in women attending a colposcopy clinic in Thailand.
    BMC Res Notes 2018 Feb 20;11(1):136. Epub 2018 Feb 20.
    Data Management Unit, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.
    Objective: To study the concordance between vaginal self- and endocervical physician-collected high-risk (hr) HPV testing in Thai women who attended a colposcopy clinic. Vaginal samples were obtained by self-sampling with a dry brush before endocervical samples were obtained by physicians. Both specimens were analyzed for hrHPV by Cobas4800 HPV test. Read More

    Aspirin is associated with low oral pH levels and antacid helps to increase oral pH.
    BMC Res Notes 2018 Feb 20;11(1):137. Epub 2018 Feb 20.
    Ministry of Health, Colombo, Sri Lanka.
    Objective: Aspirin is a commonly used medicine for primary and secondary prevention of cardiovascular diseases. It is an acidic medicine associated with gastric irritation and acid reflux, which in turn can lead to low oral pH levels. Therefore, it is important to understand the association between aspirin and oral pH levels in order to achieve an optimum oral health condition among patients who take aspirin on prescription. Read More

    Long-term effects on the progress of neuropathy after diabetic Charcot foot: an 8.5-year prospective case-control study.
    BMC Res Notes 2018 Feb 20;11(1):140. Epub 2018 Feb 20.
    Copenhagen Diabetes Foot Center (CODIF), Bispebjerg Hospital, University of Copenhagen, 2400, Copenhagen NV, Denmark.
    Objective: Charcot foot is a severe complication to diabetes mellitus, associated with diabetic neuropathy. Any long-term effects of a Charcot foot on the progress of neuropathy are still largely unexplored. The objective was to investigate whether a previous Charcot foot had any long-term effects on the progress of neuropathy. Read More

    Human regulatory proteins associate with non-coding RNAs from the EBV IR1 region.
    BMC Res Notes 2018 Feb 20;11(1):139. Epub 2018 Feb 20.
    Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, 2437 Pammel Drive, Ames, IA, 50011, USA.
    Objective: The function of Epstein-Barr virus (EBV) stable intronic sequence (sis)RNAs, non-coding RNAs transcribed from a region required for EBV-mediated cellular transformation, remain unknown. To better understand the function of ebv-sisRNA-1 and ebv-sisRNA-2 from the internal repeat (IR)1 region of EBV, we used a combination of bioinformatics and biochemistry to identify associated RNA binding proteins. The findings reported here are part of ongoing studies to determine the functions of non-coding RNAs from the IR1 region of EBV. Read More

    The transcriptome response of the ruminal methanogen Methanobrevibacter ruminantium strain M1 to the inhibitor lauric acid.
    BMC Res Notes 2018 Feb 17;11(1):135. Epub 2018 Feb 17.
    Institute of Agricultural Sciences, ETH Zurich, Universitätstrasse 2, 8092, Zurich, Switzerland.
    Objective: Lauric acid (C) is a medium-chain fatty acid that inhibits growth and production of the greenhouse gas methane by rumen methanogens such as Methanobrevibacter ruminantium. To understand the inhibitory mechanism of C, a transcriptome analysis was performed in M. ruminantium strain M1 (DSM 1093) using RNA-Seq. Read More

    Evidence of reduced treatment adherence among HIV infected paediatric and adolescent populations in Nairobi at the onset of the UNAIDS Universal Test and Treat Program.
    BMC Res Notes 2018 Feb 17;11(1):134. Epub 2018 Feb 17.
    Kenya Medical Research Institute (KEMRI), Mbagathi Road, Nairobi, Kenya.
    Objective: We conducted a retrospective cohort study to evaluate the efficacy of the World Health Organization (WHO) "Universal Test and Treat" (UTT) policy, initiated in Kenya in September 2016. Under this policy, every human immunodeficiency virus (HIV)-infected person should be initiated on antiretroviral therapy (ART). We compared intra- and inter-group viral suppression and ART adherence rates for pre-UTT (initiated on ART in March-August 2016) and UTT groups (initiated in September 2016). Read More

    Prevalence of erectile dysfunction and associated factors among diabetic men attending the diabetic clinic at Felege Hiwot Referral Hospital, Bahir Dar, North West Ethiopia, 2016.
    BMC Res Notes 2018 Feb 15;11(1):130. Epub 2018 Feb 15.
    Department of Health Education and Behavioural Sciences, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
    Objective: Even though several scholars have conducted study in different part of the world on erectile dysfunction in patients diagnosed with diabetes mellitus, it's magnitude vary among their finding with the range between 20 and 90%. This study aimed at assessing the prevalence of erectile dysfunction and associated factors among diabetic clients.

    Results: A cross sectional study was conducted from January 2016 to March, 2016. Read More

    A survey of workplace violence against physicians in the hospitals, Myanmar.
    BMC Res Notes 2018 Feb 15;11(1):133. Epub 2018 Feb 15.
    Department of Orthopaedic Surgery, (1000) bedded Nay Pyi Taw General Hospital, Nay Pyi Taw, Myanmar.
    Objective: Workplace violence in hospitals is recently becoming a major global concern in many countries. However, in Myanmar, we have felt that patients and their families have rarely made unreasonable complaints in hospitals, and then, the purpose of this study is to report the current state of workplace violence in hospitals in Myanmar. Participants are 196 physicians (108 males and 88 females) in hospitals in Myanmar. Read More

    T-ARMS PCR genotyping of SNP rs445709131 using thermostable strand displacement polymerase.
    BMC Res Notes 2018 Feb 15;11(1):132. Epub 2018 Feb 15.
    ICAR-Central Institute for Research on Cattle, Grass Farm Road, Meerut Cantt, Meerut, UP, 250001, India.
    Objectives: In a recent publication, we reported the successful use of tetra primer-amplification refractory mutation system based polymerase chain reaction (T-ARMS-PCR) for genotyping of rs445709131-SNP responsible for the bovine leukocyte adhesion deficiency (BLAD) in cattle. The SNP is characterized by higher GC content of the surrounding region, hence, the previous protocol utilized dimethyl sulfoxide as PCR enhancer. Here, the reaction cocktail was modified with the use of thermostable strand displacement polymerase (SD polymerase) instead of commonly used Taq DNA Polymerase. Read More

    Occupational exposure to HIV in a developing country: assessing knowledge and attitude of healthcare professional before and after an awareness symposium.
    BMC Res Notes 2018 Feb 15;11(1):131. Epub 2018 Feb 15.
    Department of Emergency Medicine, Aga Khan University, Karachi, Pakistan.
    Objective: Health care providers (HCPs) are at risk of occupational exposure to HIV infection. In developing world these exposure occur due to general lack of awareness, education and structured training of HCPs. The objective of the study was to asses if continuing medical education symposium can be used as an effective educational tool to improve attitude, awareness and knowledge regarding occupational exposure to HIV infection. Read More

    Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values.
    BMC Res Notes 2018 Feb 14;11(1):129. Epub 2018 Feb 14.
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
    Objectives: This study assessed the activity of thiopurine S-methyltransferase (TPMT) in Nigerians with a view to providing data on susceptibility to thiopurine toxicity, and as well generate reference activity values for clinical use.

    Results: TPMT activity, expressed as the amount of 6MMP in ng/mL after 1 h incubation at 37 °C per haemoglobin (U/g Hb), varied between 2.34 and 63. Read More

    Rasch analysis of the Trypophobia Questionnaire.
    BMC Res Notes 2018 Feb 14;11(1):128. Epub 2018 Feb 14.
    Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
    Objective: This study aimed to assess Rasch-based psychometric properties of the Trypophobia Questionnaire measuring proneness to trypophobia, which refers to disgust and unpleasantness induced by the observation of clusters of objects (e.g., lotus seed pods). Read More

    A case series on common cold to severe bronchiolitis and pneumonia in children following human metapneumovirus infection in Sri Lanka.
    BMC Res Notes 2018 Feb 14;11(1):127. Epub 2018 Feb 14.
    Department of Pediatrics, Faculty of Medical and Allied Sciences, Rajarata University of Sri Lanka, Anuradhapura, Sri Lanka.
    Objectives: The prevalence of hMPV infections in Sri Lanka has not been reported and here we report a case series of hMPV infection in children less than 5 years. Patients with ARTI were included from Teaching Hospital, Anuradhapura from March 2013 to August 2014. Indirect fluorescence assay was performed on nasopharyngeal aspirates for the identification of respiratory viruses [respiratory syncytial virus (RSV), parainfluenza virus 1, 2 and 3, influenza A and B and hMPV]. Read More

    Modulation of pro-apoptotic effects and mitochondrial potential on B16F10 cells by DODAC/PHO-S liposomes.
    BMC Res Notes 2018 Feb 14;11(1):126. Epub 2018 Feb 14.
    Biochemistry and Biophysical Laboratory, Butantan Institute, 1500, Vital Brasil Avenue, Sao Paulo, 05503-900, Brazil.
    Objective: We aimed to evaluate the potential of DODAC/PHO-S liposomes on the modulation of the expression of pro-apoptotic proteins, loss of lysosomal integrity and the mitochondrial electrical potential, compared with phosphoethanolamine.

    Results: The results of this study demonstrate that DODAC/PHO-S liposomes have exhibited broad cytotoxic potential in B16F10 murine melanoma cells, with significantly greater proportions than treatment with PHO-S. The treatment with the DODAC/PHO-S 2. Read More

    Variability of phenolic and alkaloid content in different plant parts of Carissa edulis Vahl and Zanthoxylum chalybeum Engl.
    BMC Res Notes 2018 Feb 13;11(1):125. Epub 2018 Feb 13.
    National Forestry Resources Research Institute, P.O Box 1752, Kampala, Uganda.
    Objective: The objective of the study was to investigate the relative abundance and effect of post-harvest treatment on total phenolics (TP) and total alkaloids in the leaves and bark of Carissa edulis and Zanthoxylum chalybeum, which would give an indication of the suitability of leaves as alternative sources of medicine in these plant species.

    Results: Results indicated higher levels of total phenolics than total alkaloids in both of the species under both freezing and air drying conditions. While more alkaloids were found in leaves compared to bark, there was no difference in abundance of phenols between the plant parts of both species. Read More

    Potassium permanganate cleansing is an effective sanitary method for the reduction of bacterial bioload on raw Coriandrum sativum.
    BMC Res Notes 2018 Feb 13;11(1):124. Epub 2018 Feb 13.
    Manipal College of Medical Sciences, Pokhara, Nepal.
    Objective: Raw vegetables including flowers, leaves, stems, and roots are important carriers of food borne pathogens. We evaluated the bacteriological contamination of unwashed coriander leaves, and effectiveness of cleansing with 0.1% potassium permanganate solution as decontamination method. Read More

    Simple descriptive missing data indicators in longitudinal studies with attrition, intermittent missing data and a high number of follow-ups.
    BMC Res Notes 2018 Feb 13;11(1):123. Epub 2018 Feb 13.
    Department of Work Psychology and Physiology, National Institute of Occupational Health, PO box 8149 Dep, 0033, Oslo, Norway.
    Objective: Missing data in longitudinal studies may constitute a source of bias. We suggest three simple missing data indicators for the initial phase of getting an overview of the missingness pattern in a dataset with a high number of follow-ups. Possible use of the indicators is exemplified in two datasets allowing wave nonresponse; a Norwegian dataset of 420 subjects examined at 21 occasions during 6. Read More

    Histopathologic characteristics of biopsies from dogs undergoing surgery with concurrent gross splenic and hepatic masses: 125 cases (2012-2016).
    BMC Res Notes 2018 Feb 13;11(1):122. Epub 2018 Feb 13.
    Biostatistics Unit, Feinstein Institute for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY, 11030, USA.
    Objective: To investigate the histopathologic characteristics of concurrent splenic and liver masses in dogs undergoing splenectomy and liver mass biopsy/resection. Medical records of 125 client-owned dogs found to have splenic mass or masses and a liver mass or masses during surgery were examined. Signalment (age, sex, breed), body weight, and results of histopathology were recorded for all dogs. Read More

    Assessment of GeneXpert GxAlert platform for multi-drug resistant tuberculosis diagnosis and patients' linkage to care in Tanzania.
    BMC Res Notes 2018 Feb 9;11(1):121. Epub 2018 Feb 9.
    National Institute for Medical Research, Muhimbili Medical Research Centre, Dar es Salaam, Tanzania.
    Objective: The gap between patients diagnosed with multi-drug resistant tuberculosis (MDR-TB) and enrolment in treatment is one of the major challenges in tuberculosis control programmes. A 4-year (2013-2016) retrospective review of patients' clinical data and subsequent in-depth interviews with health providers were conducted to assess the effectiveness of the GeneXpert GxAlert platform for MDR-TB diagnosis and its impact on linkage of patients to care in Tanzania.

    Results: A total of 782 new rifampicin resistant cases were notified, but only 242 (32. Read More

    Transcriptomic response in Acropora muricata under acute temperature stress follows preconditioned seasonal temperature fluctuations.
    BMC Res Notes 2018 Feb 9;11(1):119. Epub 2018 Feb 9.
    Biodiversity Research Center, Academia Sinica, Taipei, Taiwan.
    Objective: Global climate change has resulted in the decline of health and condition of various coral reefs worldwide. Here, we describe expression profiles of Acropora muricata collected during opposing seasons in Otsuki, Kochi, Japan to define the capacity of corals to cope with changing environmental conditions. Coral communities in Otsuki experience large temperature fluctuations between the winter (~ 16 °C) and summer (~ 27 °C). Read More

    Patient delay in seeking tuberculosis diagnosis and associated factors in Hadiya Zone, Southern Ethiopia.
    BMC Res Notes 2018 Feb 9;11(1):115. Epub 2018 Feb 9.
    Department of Public Health, Hosanna College of Health Sciences, Hosanna, Ethiopia.
    Objective: To assess patient delay in seeking tuberculosis diagnosis and associated factors in Hadiya Zone, Southern Ethiopia.

    Results: The median patient delay in tuberculosis diagnosis in Hadiya Zone was found to be 30 days. Socioeconomic and perception related factors were identified as independent predictors for tuberculosis diagnosis delay. Read More

    Oxford Screening CSF and Respiratory samples ('OSCAR'): results of a pilot study to screen clinical samples from a diagnostic microbiology laboratory for viruses using Illumina next generation sequencing.
    BMC Res Notes 2018 Feb 9;11(1):120. Epub 2018 Feb 9.
    Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford, OX1 3SY, UK.
    Objectives: There is increasing interest in the use of metagenomic (next generation sequencing, NGS) approaches for diagnosis of infection. We undertook a pilot study to screen samples submitted to a diagnostic microbiology laboratory in a UK teaching hospital using Illumina HiSeq. In the short-term, this small dataset provides insights into the virome of human respiratory and cerebrospinal fluid (CSF) samples. Read More

    Children with oedema recover better than those with severe wasting in outpatient therapeutic program at Boloso Sore district, Southwest Ethiopia.
    BMC Res Notes 2018 Feb 9;11(1):118. Epub 2018 Feb 9.
    School of Public Health, Wolaita Sodo University, 126, Wolaita Sodo, Ethiopia.
    Objectives: Severely undernourished young children clinically present with a typical nutritional oedema or none-oedematous. However, research evidence is limited on how these types predict treatment outcomes in Ethiopia. This study was aimed to compare oedematous and none-oedematous children for their treatment outcomes in Boloso Sore district in Southwest Ethiopia. Read More

    Proteome-wide comparison between the amino acid composition of domains and linkers.
    BMC Res Notes 2018 Feb 9;11(1):117. Epub 2018 Feb 9.
    Faculty of Biology, Johannes Gutenberg University Mainz, Gresemundweg 2, 55128, Mainz, Germany.
    Objective: Amino acid composition is a sequence feature that has been extensively used to characterize proteomes of many species and protein families. Yet the analysis of amino acid composition of protein domains and the linkers connecting them has received less attention. Here, we perform both a comprehensive full-proteome amino acid composition analysis and a similar analysis focusing on domains and linkers, to uncover domain- or linker-specific differential amino acid usage patterns. Read More

    Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy.
    BMC Res Notes 2018 Feb 9;11(1):116. Epub 2018 Feb 9.
    Department of Periodontology, Tokyo Dental College, Tokyo, Japan.
    Objective: This study aimed to evaluate clinically the effect of a novel dentifrice containing three kinds of bactericidal ingredients on periodontal disease.

    Results: This was a single-arm, prospective clinical study that enrolled patients with periodontitis undergoing supportive periodontal therapy. Periodontal examination, microbiological testing of saliva samples, and evaluation of inflammatory markers (IL-1β, IL-6, IL-8, TNF-α) in gingival crevicular fluid were performed. Read More

    The correlation between serum AMH and HOMA-IR among PCOS phenotypes.
    BMC Res Notes 2018 Feb 9;11(1):114. Epub 2018 Feb 9.
    Division of Reproductive Endocrinology and Infertility, Department of Obstetric and Gynecology Faculty of Medicine, Universitas Indonesia; Dr, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
    Background: Polycystic ovarian syndrome (PCOS) is known to be one of the most prevalent endocrine disorders affecting reproductive age women. One of the endocrine disorder is hyperinsulinemia, which corresponds with the severity of PCOS. However, the pathogenesis of PCOS is not fully understood, but one theory of anti-mullerian hormone (AMH) has been proposed as one of the factor related to the degree of severity of PCOS. Read More

    Endodontic management of mandibular canine with two roots and two canals: a rare case report.
    BMC Res Notes 2018 Feb 8;11(1):111. Epub 2018 Feb 8.
    Department of Conservative Dentistry and Endodontics, Kathmandu Medical College, Kathmandu, Nepal.
    Background: In general, mandibular canines have a single root and a single canal. The occurrence of two roots and two canals is a rare entity ranging from 1 to 5%. The anatomy of root canal morphology plays a decisive role in determining the conditions under which endodontic treatment can be performed effectively. Read More

    Effect of spirometry on intra-thoracic pressures.
    BMC Res Notes 2018 Feb 8;11(1):110. Epub 2018 Feb 8.
    Centre for Human Performance, Exercise and Rehabilitation, Brunel University, London, UK.
    Objective: Due to the high intra-thoracic pressures associated with forced vital capacity manoeuvres, spirometry is contraindicated for vulnerable patients. However, the typical pressure response to spirometry has not been reported. Eight healthy, recreationally-active men performed spirometry while oesophageal pressure was recorded using a latex balloon-tipped catheter. Read More

    Adipocytokines in obese Ghanaian subjects with or without type 2 diabetes.
    BMC Res Notes 2018 Feb 8;11(1):109. Epub 2018 Feb 8.
    Department of Nutrition and Dietetics, S.B.A.H.S, Korle-Bu, Accra, Ghana.
    Objective: This study aimed to evaluate serum leptin and high sensitivity C-reactive protein (hsCRP) concentrations in obese Ghanaians with or without type 2 diabetes and to find out the extent to which their levels are influenced by underlying disorders.

    Results: Obese subjects with type 2 diabetes had lower leptin but higher hsCRP levels compared with obese non-diabetic controls. There were negative correlations within the control group for glucose vs % muscle mass (r = - 0. Read More

    Seroprevalence of hepatitis B surface antigen (HBsAg) in Bo, Sierra Leone, 2012-2013.
    BMC Res Notes 2018 Feb 8;11(1):113. Epub 2018 Feb 8.
    Center for Biomolecular Science & Engineering, U.S. Naval Research Laboratory, Washington, DC, USA.
    Objective: The aim of this study was to determine the prevalence of hepatitis B surface antigen (HBsAg) among febrile individuals tested at Mercy Hospital Research Laboratory (MHRL) in Bo, Sierra Leone.

    Results: A total of 860 febrile individuals ages 5 years and older were tested by MHRL between July 2012 and June 2013 with a Standard Diagnostics Bioline HBsAg rapid diagnostic test. The overall HBsAg prevalence rate was 13. Read More

    Bluetongue disease in small ruminants in south western Ethiopia: cross-sectional sero-epidemiological study.
    BMC Res Notes 2018 Feb 8;11(1):112. Epub 2018 Feb 8.
    Virus Laboratory, Center for Animal Disease Research and Diagnosis (CADRD), Indian Veterinary Research Institute (IVRI), Izatnagar, Uttar Pradesh, 243 122, India.
    Objective: The status of bluetongue disease, vectors for transmission of the disease and the serotypes involved are not clearly known in Ethiopia. This sero-epidemiological study was conducted to determine the seroprevalence and associated risk factors of bluetongue in small ruminants of South Western Ethiopia.

    Result: 422 serum samples were screened for the presence of bluetongue virus (BTV) specific antibodies using competitive enzyme-linked immunosorbent assay (c-ELISA) and 30. Read More

    Incidence of acute lymphocytic leukemia in Calgary, Alberta, Canada: a retrospective cohort study.
    BMC Res Notes 2018 Feb 7;11(1):104. Epub 2018 Feb 7.
    Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
    Objective: Acute lymphocytic leukemia (ALL) is a rare malignant neoplasm that develops from abnormal lymphoid stem cells. ALL incidence is highest among children and declines towards adolescence. There is limited data on the epidemiology of ALL, especially in Canada. Read More

    Cryptosporidium infection in bovine calves: prevalence and potential risk factors in northwest Ethiopia.
    BMC Res Notes 2018 Feb 7;11(1):105. Epub 2018 Feb 7.
    College of Veterinary Medicine and Agriculture, Addis Ababa University, P.O. Box: 38, Debre-Zeit, Ethiopia.
    Objective: Cryptosporidium is an enteric protozoan organism that causes gastrointestinal disorders in different animals, mainly in calves. The parasite has also a zoonotic importance of children and immunocompromised patients. However, data are limited to northwest Ethiopia. Read More

    Double non-contiguous fractures in a patient with spondylo-epiphyseal dysplasia with spinal ankylosis treated with open and percutaneous spinal fixation technique: a case report.
    BMC Res Notes 2018 Feb 7;11(1):106. Epub 2018 Feb 7.
    Department of Spine Surgery, Saga Medical Centre, Koseikan, 400 Nakabaru Kase-Machi, Saga, 840-8571, Japan.
    Background: Patients with ankylosing spines are susceptible to developing spinal fractures even with minor trauma and can develop early or late neurological injuries. These fractures require early and aggressive surgical management to enable spinal stability and/or neural decompression. Being highly unstable by nature, they require relatively long segment instrumentation and fusion, which can increase paravertebral soft tissue damage and perioperative bleeding. Read More

    Discrimination between some Mycoplasma spp. and Acholeplasma laidlawii in bovine milk using high resolution melting curve analysis.
    BMC Res Notes 2018 Feb 7;11(1):107. Epub 2018 Feb 7.
    School of Animal and Veterinary Sciences, Roseworthy Campus, The University of Adelaide, Roseworthy, South Australia, 5371, Australia.
    Objectives: This study aimed to provide a rapid, accurate and cost-effective diagnostic real time polymerase chain reaction-high resolution melting curve assay (PCR-HRM) to identify and distinguish between four different mycoplasmas and Acholeplasma laidlawii isolated at cow-level from a single commercial dairy farm in South Australia. One set of genus-level universal primers was designed targeting the 16S ribosomal RNA gene.

    Results: Real time PCR-HRM analysis was able to identify and distinguish between five different mollicutes, namely A. Read More

    Direct serogrouping of Dichelobacter nodosus from Victorian farms using conventional multiplex polymerase chain reaction.
    BMC Res Notes 2018 Feb 7;11(1):108. Epub 2018 Feb 7.
    Department of Animal, Plant and Soil Science and Centre for AgriBioscience (AgriBio), La Trobe University, Bundoora, Melbourne, VIC, Australia.
    Objective: Dichelobacter nodosus is the causative agent of footrot in sheep. Ovine footrot is a major problem in Australia that results in large economic losses and a represents a very significant animal welfare issue. D. Read More

    Comparative genomics reveals a widespread distribution of an exopolysaccharide biosynthesis gene cluster among Vibrionaceae.
    BMC Res Notes 2018 Feb 6;11(1):102. Epub 2018 Feb 6.
    Ifremer, Atlantique Center, Biotechnology and Marine Resources Unit, Marine Ecosystems and Marine Molecules for the Biotechnologies Laboratory, Rue de l'Ile d'Yeu, BP21105, 44311, Nantes Cedex 3, France.
    Objectives: The eps locus in Vibrio diabolicus is involved in the production of the biotechnologically valuable HE800 EPS. In this study, the distribution and diversity of similar eps gene clusters across Vibrionaceae and its variability in relation to phylogenetic relationship were investigated. The aim was to provide a better knowledge of the eps gene cluster importance and to facilitate discovery of new EPS with potent interesting bioactivities. Read More

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