6,825 results match your criteria BMC Research Notes [Journal]


Predictors associated with HIV/AIDS patients dropout from antiretroviral therapy at Mettu Karl Hospital, southwest Ethiopia.

Authors:
Melaku Tadege

BMC Res Notes 2019 Apr 18;12(1):232. Epub 2019 Apr 18.

Department of Statistics, Injibara University, Injibara, Amhara, Ethiopia.

Objective: The aim of this study was to determine the major risk factors of antiretroviral therapy dropout. The retrospective cohort research design was applied. 1512 HIV patients were included from Mettu Karl Hospital in Illubabor Zone, southwest part of Ethiopia from September 2005 to January 2018. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4267-3DOI Listing
April 2019
1 Read

Effect of Peer Assisted Learning (PAL) education on knowledge, attitude and behavior related to prevention and control of diabetes.

BMC Res Notes 2019 Apr 15;12(1):227. Epub 2019 Apr 15.

Neyriz Health and Care Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: The present study aimed to compare the effect of Peer Assisted Learning (PAL) method and routine lecture on knowledge, attitudes, and behaviors of participants in the prevention of diabetes.

Results: The results showed that one month after the intervention and the implementation of the educational program, the mean scores of the two groups in terms of knowledge, attitude, and behavior increased significantly. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4261-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466761PMC
April 2019
1 Read

Treatment potential of pathogen-reactive antibodies sequentially purified from pooled human immunoglobulin.

BMC Res Notes 2019 Apr 15;12(1):228. Epub 2019 Apr 15.

Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.

Objective: Intravenous immune globulin (IVIG), pooled from human blood, is a polyspecific antibody preparation that inhibits the super-antigenic proteins associated with streptococcal and staphylococcal toxic shock, and the Shiga toxin. In addition to this toxin-neutralising activity, IVIG contains other pathogen-reactive antibodies that may confer additional therapeutic benefits. We sought to determine if pathogen-reactive antibodies that promote opsonophagocytosis of different organisms can be sequentially affinity-purified from one IVIG preparation. Read More

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http://dx.doi.org/10.1186/s13104-019-4262-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466806PMC
April 2019
1 Read

Use of headspace-gas chromatography-ion mobility spectrometry to detect volatile fingerprints of palm fibre oil and sludge palm oil in samples of crude palm oil.

BMC Res Notes 2019 Apr 16;12(1):229. Epub 2019 Apr 16.

Faculty of Computing, Engineering and Science, University of South Wales, Pontypridd, CF37 1DL, UK.

Objective: The addition of residual oils such as palm fibre oil (PFO) and sludge palm oil (SPO) to crude palm oil (CPO) can be problematic within supply chains. PFO is thought to aggravate the accumulation of monochloropropanediols (MCPDs) in CPO, whilst SPO is an acidic by-product of CPO milling and is not fit for human consumption. Traditional targeted techniques to detect such additives are costly, time-consuming and require highly trained operators. Read More

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http://dx.doi.org/10.1186/s13104-019-4263-7DOI Listing

Prevalence, infection intensity and associated factors of soil transmitted helminths among primary school children in Gurage zone, South Central Ethiopia: a cross-sectional study design.

BMC Res Notes 2019 Apr 16;12(1):231. Epub 2019 Apr 16.

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wolkite University, P.O. Box 07, Wolkite, Ethiopia.

Objective: The aim of this study was to determine the prevalence of soil transmitted helminthes among primary school children. School based cross-sectional study design was employed. A total of six hundred study subjects were selected by a multistage sampling method. Read More

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http://dx.doi.org/10.1186/s13104-019-4254-8DOI Listing

Monomorium ant is a carrier for pathogenic and potentially pathogenic bacteria.

BMC Res Notes 2019 Apr 16;12(1):230. Epub 2019 Apr 16.

Crop & Environment Sciences, Harper Adams University, Edgmond, Newport, TF10 8NB, UK.

Objectives: Household ants are regarded as a major household pest and their close association with microorganisms and people means that they may constitute a disease risk. Our study is the first to provide information on the pathogenicity of Monomorium spp. a common insect in Kuwait by quantifying and identifying the exoskeleton bacterial burden. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4266-4DOI Listing
April 2019
2 Reads

The trials and tribulations of conducting an m-health pilot randomized controlled trial to improve oral cancer therapy adherence: recommendations for future multisite, non-drug clinical trials.

BMC Res Notes 2019 Apr 15;12(1):226. Epub 2019 Apr 15.

Peter MacCallum Cancer Centre, Parkville, Melbourne, VIC, Australia.

Objective: Integrating mobile phone-based health (m-health) interventions into healthcare systems is one solution to improve access to services for the growing number of patients with chronic illness. Practical challenges such as poor recruitment and inadequate resource allocation can hamper the assessment of such interventions with clinical trial methodology. This paper highlights the challenges encountered during a pilot randomized controlled trial of an m-health medication adherence intervention and offers recommendations for future multi-site, non-drug clinical trials. Read More

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http://dx.doi.org/10.1186/s13104-019-4264-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466650PMC
April 2019
1 Read

Estimating transfection efficiency in differentiated and undifferentiated neural cells.

BMC Res Notes 2019 Apr 15;12(1):225. Epub 2019 Apr 15.

Behavioral Genetics Unit, Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia.

Objective: Delivery of constructs for silencing or over-expressing genes or their modified versions is a crucial step for studying neuronal cell biology. Therefore, efficient transfection is important for the success of these experimental techniques especially in post-mitotic cells like neurons. In this study, we have assessed the transfection rate, using a previously established protocol, in both primary cortical cultures and neuroblastoma cell lines. Read More

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http://dx.doi.org/10.1186/s13104-019-4249-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466792PMC

Zero-valent iron sand filtration reduces concentrations of virus-like particles and modifies virome community composition in reclaimed water used for agricultural irrigation.

BMC Res Notes 2019 Apr 11;12(1):223. Epub 2019 Apr 11.

Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, School of Public Health Building (255), 4200 Valley Drive, Room 2234P, College Park, MD, 20742, USA.

Objective: Zero-valent iron sand filtration can remove multiple contaminants, including some types of pathogenic bacteria, from contaminated water. However, its efficacy at removing complex viral populations, such as those found in reclaimed water used for agricultural irrigation, has not been fully evaluated. Therefore, this study utilized metagenomic sequencing and epifluorescent microscopy to enumerate and characterize viral populations found in reclaimed water and zero-valent iron-sand filtered reclaimed water sampled three times during a larger greenhouse study. Read More

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http://dx.doi.org/10.1186/s13104-019-4251-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458639PMC

A human specific Alu DNA cassette is found flanking the genes of transcription factor AP2.

BMC Res Notes 2019 Apr 11;12(1):222. Epub 2019 Apr 11.

Basic Medical Sciences Dept., College of Dentistry, Almustqbal University, PO Box 156, Buraida, Qassim, 51411, Saudi Arabia.

Objective: Alu elements are retroposons that invaded the primate genome and shaped its biology. Some Alus inserted recently and are polymorphic in the human population. It is these Alus that are being sought after in disease association studies and regulatory biology. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4247-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458609PMC
April 2019
2 Reads

Level of knowledge among health care providers on preparation of injectable artesunate for treatment of severe malaria in public health facilities in Tanzania.

BMC Res Notes 2019 Apr 11;12(1):224. Epub 2019 Apr 11.

Muhimbili University of Health & Allied Sciences, Dar-es-Salaam, Tanzania.

Objective: In Tanzania, seminars and training on the preparation and administration of injectable artesunate were given to health care providers (HCP) during its introduction in 2013. Published evidence on knowledge of its preparation among HCP in public health facilities is scarce. The study determined level of knowledge of health care providers (HCP) in public health facilities on the preparation of injectable artesunate for severe malaria. Read More

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http://dx.doi.org/10.1186/s13104-019-4257-5DOI Listing

Tobacco use and caries increment in young adults: a prospective observational study.

BMC Res Notes 2019 Apr 11;12(1):218. Epub 2019 Apr 11.

Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Norre Allé 20, 2200, Copenhagen N, Denmark.

Objective: Tobacco use has a negative influence on general and oral health but data concerning caries are mainly derived from epidemiological and cross-sectional studies. The aim of this study was to investigate smoking and use of smokeless tobacco (Swedish snus) as determinants of dental caries increment in young adults over 3 years. The baseline cohort consisted of 1295 19-year-olds registered at eight Public Dental Clinics representing socioeconomic strata. Read More

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http://dx.doi.org/10.1186/s13104-019-4253-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458795PMC

Prospective cohort of adult oral health in Piracicaba, SP, Brazil.

BMC Res Notes 2019 Apr 11;12(1):221. Epub 2019 Apr 11.

Department of Community Dentistry, Piracicaba Dental School, University of Campinas, Avenue Limeira, 901, P.O. Box: 52, Piracicaba, SP, Zip Code: 13414-018, Brazil.

Objective: To describe the methodological aspects of a Prospective Cohort Study of adult oral health in Piracicaba, Brazil.

Results: This Prospective Cohort Study evaluated adults (20-64 years old) between the years of 2011 and 2015, in Piracicaba, São Paulo, Brazil. The main objective was to evaluate the risk factors for tooth loss in adults. Read More

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http://dx.doi.org/10.1186/s13104-019-4243-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458779PMC

Bacillus subtilis RarA forms damage-inducible foci that scan the entire cell.

BMC Res Notes 2019 Apr 11;12(1):219. Epub 2019 Apr 11.

SYNMIKRO, LOEWE Center for Synthetic Microbiology, Marburg, Germany.

Objectives: Little is known about the activity and dynamics of ATPase RarA in B. subtilis, proposed to act at stalled DNA replication forks due to DNA damage. We performed fluorescence microscopy time lapse experiments with a functional RarA-mVenus fusion to visualize the dynamics of RarA during conditions that generate DNA damage. Read More

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http://dx.doi.org/10.1186/s13104-019-4252-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458690PMC

An OpenMP-based tool for finding longest common subsequence in bioinformatics.

BMC Res Notes 2019 Apr 11;12(1):220. Epub 2019 Apr 11.

Department of Biochemistry and Medical Genetics and The George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Room 308-Basic Medical Sciences Building, 745 Bannatyne Avenue, Winnipeg, MB, R3E 0J9, Canada.

Objective: Finding the longest common subsequence (LCS) among sequences is NP-hard. This is an important problem in bioinformatics for DNA sequence alignment and pattern discovery. In this research, we propose new CPU-based parallel implementations that can provide significant advantages in terms of execution times, monetary cost, and pervasiveness in finding LCS of DNA sequences in an environment where Graphics Processing Units are not available. Read More

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http://dx.doi.org/10.1186/s13104-019-4256-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458724PMC

Implementation of palliative care for patients with terminal diseases from the viewpoint of healthcare personnel.

BMC Res Notes 2019 Apr 8;12(1):217. Epub 2019 Apr 8.

Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Jl. Pasteur No. 38, Bandung, 40161, Indonesia.

Objective: In Indonesia, palliative care has not been uniformly implemented at all levels of healthcare facilities. Healthcare personnel play an important role in providing that care. This study aimed to explore the current conditions and expectations regarding palliative care from the perspective of healthcare personnel. Read More

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http://dx.doi.org/10.1186/s13104-019-4260-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454743PMC

Work motivation and its effects on organizational performance: the case of nurses in Hawassa public and private hospitals: Mixed method study approach.

BMC Res Notes 2019 Apr 8;12(1):213. Epub 2019 Apr 8.

African Institute of Governance & Development, Ethiopian Civil Service University, Addis Ababa, Ethiopia.

Objective: The main objective of the study was to assess level of motivation, how nurses perceived work motivation and its effects on organizational performance among nurses working in Hawassa public and private hospitals.

Results: It was found that majority (64.1%) of the nurses perceived motivation as motivators. Read More

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http://dx.doi.org/10.1186/s13104-019-4255-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454626PMC

Self-care practices regarding diabetes among diabetic patients in West Ethiopia.

BMC Res Notes 2019 Apr 8;12(1):212. Epub 2019 Apr 8.

Clinical Pharmacy Unit, Department of Pharmacy, College of Health Sciences, Wollega University, Nekemte, Oromia, Ethiopia.

Objective: To assess the self-care practices and associated factors among diabetic patients in West Ethiopia.

Results: A total of 252 study participants were included in the study, of this 54.8% were male. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4258-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454742PMC
April 2019
7 Reads

Predictive value of persistent NS1 antigen positivity beyond 3rd day for dengue haemorrhagic fever in Sri Lankan children.

BMC Res Notes 2019 Apr 8;12(1):214. Epub 2019 Apr 8.

Centre for Clinical Management of Dengue and Dengue Haemorrhagic Fever (CCMDDHF), District General Hospital Negombo, Negombo, Sri Lanka.

Objective: Dengue haemorrhagic fever (DHF) is a major public health concern responsible for significant morbidity in both adult and paediatric populations in Sri Lanka. This study examined if persistent non structural protein 1 (NS1) antigen positivity beyond day 3 was predictive of the occurrence of dengue haemorrhagic fever. The patients were followed up during their in-hospital stay and the severity of the illness was classified according to the WHO classification. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4250-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454706PMC
April 2019
2 Reads

Effects of vitamin D3 and its chemical analogs on the growth of Hodgkin's lymphoma, in vitro.

BMC Res Notes 2019 Apr 8;12(1):216. Epub 2019 Apr 8.

Department of Biological Sciences, Lehman College, City University of New York, Bronx, NY, 10468, USA.

Objective: Vitamin D receptor (VDR) activities have been noted for a number of B cell malignancies which showed varying sensitivities to vitamin D3 (1,25-dihydroxyvitamin D3, VD3, calcitriol) and its synthetic analogs. The objective of this study was to address the potential effects of VD3 and vitamin D3 analogs (VDAs) on the growth of Hodgkin's lymphoma (HL), a malignant pathology of B cell origin, in vitro.

Results: Immunofluorescence staining showed the expression of VDR by primary Hodgkin's (H) and Reed-Sternberg (RS)-HRS-tumor cells in HL histological sections. Read More

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http://dx.doi.org/10.1186/s13104-019-4241-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454773PMC
April 2019
1 Read

Appropriate complementary feeding practice and associated factors among mothers having children aged 6-24 months in Debre Tabor Hospital, North West Ethiopia, 2016.

BMC Res Notes 2019 Apr 8;12(1):215. Epub 2019 Apr 8.

School of Midwifery, University of Gondar, Gondar City, Ethiopia.

Objective: This study was aimed to assess appropriate complementary feeding practice and associated factors among mothers having children aged 6-24 months in Debre Tabor Hospital, North West Ethiopia, 2016.

Results: In this study, 37.2% of mothers had appropriate complementary feeding practice. Read More

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http://dx.doi.org/10.1186/s13104-019-4259-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454628PMC

Schistosoma mansoni infection among preschool age children attending Erer Health Center, Ethiopia and the response rate to praziquantel.

BMC Res Notes 2019 Apr 5;12(1):211. Epub 2019 Apr 5.

Department of Microbiology Immunology and Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Objective: Preschool age children (PSAC) are excluded from community based praziquantel treatment programs mainly due to paucity of evidence on the magnitude of schistosomiasis, efficacy and safety of this treatment in PSAC. The aim of this study is to assess Schistosoma mansoni infection rate and evaluate response to praziquantel in PSAC. A facility based longitudinal study was employed from April to June 2016 at Erer Health Center, Eastern Ethiopia. Read More

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http://dx.doi.org/10.1186/s13104-019-4246-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451229PMC
April 2019
1 Read

Erectile dysfunction and associated factors among men with diabetes mellitus from a tertiary diabetic center in Northern Sri Lanka.

BMC Res Notes 2019 Apr 5;12(1):210. Epub 2019 Apr 5.

Teaching Hospital Jaffna, Jaffna, Sri Lanka.

Objective: Prevalence of erectile dysfunction (ED) in diabetic men is considerably high but it is often underdiagnosed and undermanaged. There were no data available about the prevalence and the risk factors of ED in our region. So a cross-sectional study was conducted to identify the prevalence and associated risk factors of ED in a tertiary care diabetic center in Northern Sri Lanka. Read More

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http://dx.doi.org/10.1186/s13104-019-4244-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451292PMC
April 2019
1 Read

Trend in magnitude of tuberculosis in Awi Zone, Northwest Ethiopia: a five-year tuberculosis surveillance data analysis.

BMC Res Notes 2019 Apr 5;12(1):209. Epub 2019 Apr 5.

Department of Health Promotion and Behavioural Sciences, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Objective: Ethiopia is among the 30 high tuberculosis (TB) burden countries with annual estimated TB incidence of 164/100,000 population and death rate of 28/100,000 population for 2017. We analyzed the trend in magnitude of tuberculosis in Awi Zone from July 08/2011 up to June 27/2016.

Results: Tuberculosis surveillance data (2012 to 2016) was extracted from Awi Zonal Health Department Health Management Information System database and TB program unit and analyzed by Microsoft Excel 2007. Read More

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http://dx.doi.org/10.1186/s13104-019-4234-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451271PMC
April 2019
1 Read

Predictors of poor glycemic control among patients with type 2 diabetes on follow-up care at a tertiary healthcare setting in Ethiopia.

BMC Res Notes 2019 Apr 4;12(1):207. Epub 2019 Apr 4.

School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.

Objective: Contemporary clinical guidelines endorsed that glycemic control is the ultimate goal in the management patients with diabetes. The aim of this study was to assess the prevalence of glycemic control and to identify predictors of poor glycemic control in patients with type 2 diabetes (T2D). A cross-sectional study was conducted among systematically selected 357 diabetic patients. Read More

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http://dx.doi.org/10.1186/s13104-019-4248-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449968PMC
April 2019
1 Read

Correlating physical activity and quality of life of healthcare workers.

BMC Res Notes 2019 Apr 4;12(1):208. Epub 2019 Apr 4.

Faculty of Social and Education Policy, University of Peloponnese, 20131, Corinth, Greece.

Objective: The purpose of the present study was to investigate healthcare workers' physical exercise levels linked to their quality of life. Healthcare workers' from all departments of a General hospital participated in the study. The instruments used for data collection regarding quality of life and physical exercise (Short Form Health Survey (SF-36) and International Physical Activity Questionnaire-short form). Read More

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http://dx.doi.org/10.1186/s13104-019-4240-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449892PMC
April 2019
1 Read

Attitude of Nursing and Midwifery students towards clinical practice and its associated factors in Northwest Ethiopia: a cross-sectional study.

BMC Res Notes 2019 Apr 3;12(1):205. Epub 2019 Apr 3.

Department of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Objective: The aim of this study was to assess the attitude of Nursing and Midwifery students towards clinical practice and its associated factors at University of Gondar, Northwest Ethiopia. 2018.

Result: The prevalence of a favorable attitude towards clinical practice was found to be 42. Read More

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http://dx.doi.org/10.1186/s13104-019-4230-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448283PMC

Dyslipidaemia is common among patients with type 2 diabetes: a cross-sectional study at Tema Port Clinic.

BMC Res Notes 2019 Apr 3;12(1):204. Epub 2019 Apr 3.

Department of Chemical Pathology, School of Biomedical and Allied Health Sciences (S.B.A.H.S.), University of Ghana, Accra, Ghana.

Objective: This study aimed to evaluate dyslipidemia in Ghanaian subjects with type 2 diabetes.

Results: Hundred individuals with type 2 diabetes and 61 apparently healthy controls participated. The prevalence of hypercholesterolemia among persons with type 2 diabetes was 53%. Read More

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http://dx.doi.org/10.1186/s13104-019-4245-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448301PMC
April 2019
1 Read

Preliminary study on the expression of endothelial cell biology related genes in the liver of dengue virus infected mice treated with Carica papaya leaf juice.

BMC Res Notes 2019 Apr 3;12(1):206. Epub 2019 Apr 3.

Herbal Medicine Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia.

Objective: The purpose of this study was to profile and identify the endothelial cell biology related genes that are affected by dengue virus infection in the liver tissue of AG129 mice, with and without Carica papaya leaf juice treatment.

Results: The dengue fever mouse model was established by intraperitoneal inoculation of dengue virus, New Guinea C strain at 2 × 10 PFU. Daily oral administration of 1000 mg/kg freeze-dried C. Read More

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http://dx.doi.org/10.1186/s13104-019-4242-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448258PMC
April 2019
2 Reads

Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep).

BMC Res Notes 2019 Apr 3;12(1):203. Epub 2019 Apr 3.

Mental Health Services in Esbjerg, Region of Southern Denmark, Gl. Vardevej 101, DK-6715, Esbjerg N, Denmark.

Objective: To examine whether vitamin D supplementation in patients with depression would result in a reduction in Hamilton D-17 depression score (primary outcome) at 3 and 6 months compared to controls and to explore the correlations between serum vitamin D and symptoms of depression, wellbeing, systolic blood pressure, and waist circumference. In this outpatient multicentre study conducted between 2010 and 2013, patients, 18-65 years old, diagnosed with mild to severe depression were randomly assigned to receive D supplementation 70 micrograms daily or placebo on top of standard treatment. Participants, care givers and those assessing the outcomes were blinded to group assignment. Read More

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http://dx.doi.org/10.1186/s13104-019-4218-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446320PMC

Coherence and reliability of a wearable inertial measurement unit for measuring postural sway.

BMC Res Notes 2019 Apr 2;12(1):201. Epub 2019 Apr 2.

Department of Health Sciences/Physiotherapy, Health Science Centre, Lund University, Box 157, 221 00, Lund, Sweden.

Objective: The aim of this study was to test the coherence of a wearable device, an inertial measurement unit (IMU) against the gold standard; also, to test the intra-trial reliability. This study has a cross-sectional design, where measurement of postural sway in the medio-lateral and anterior-posterior directions was performed simultaneously on a force plate and with a IMU called the Snubblometer ("snubbla" is stumble in Swedish). Thirty-two healthy volunteers participated in the tests. Read More

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http://dx.doi.org/10.1186/s13104-019-4238-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446366PMC
April 2019
1 Read

Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel.

BMC Res Notes 2019 Apr 2;12(1):199. Epub 2019 Apr 2.

Department of Clinical Sciences, Division of Medicine, Skåne University Hospital, Lund University, Malmö, Sweden.

Objective: To evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardised meal as well as 30 and 120 min afterwards with the Proseek Multiplex Oncology II kit. Read More

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http://dx.doi.org/10.1186/s13104-019-4237-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446403PMC
April 2019
2 Reads

Diagnostic accuracy of ultrasound characteristics in the identification of malignant thyroid nodules.

BMC Res Notes 2019 Apr 2;12(1):193. Epub 2019 Apr 2.

Department of Community Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, 50008, Sri Lanka.

Objective: This study was aimed at determining the diagnostic accuracy of the ultrasound characteristics in the identification of malignant thyroid nodules in patients attending the surgical clinic at a tertiary care hospital in Sri Lanka.

Results: This prospective validation study was conducted among 263 patients attending the surgical clinic at a tertiary care hospital, Sri Lanka. The ultrasound characteristics having statistically significant associations with thyroid malignancies were identified by employing a multivariable analysis. Read More

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http://dx.doi.org/10.1186/s13104-019-4235-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444851PMC
April 2019
1 Read

A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters.

BMC Res Notes 2019 Apr 2;12(1):194. Epub 2019 Apr 2.

Bioinformatics Group, Wageningen University & Research, Wageningen, The Netherlands.

Objective: Plants produce a plethora of specialized metabolites to defend themselves against pathogens and insects, to attract pollinators and to communicate with other organisms. Many of these are also applied in the clinic and in agriculture. Genes encoding the enzymes that drive the biosynthesis of these metabolites are sometimes physically grouped on the chromosome, in regions called biosynthetic gene clusters (BGCs). Read More

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http://dx.doi.org/10.1186/s13104-019-4222-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444639PMC
April 2019
3 Reads

Synthesis of γ-hydroxy-α-(arylmethyl)carboxylic acids from lactones: pathway to a structural motif derived from lactic acid and amino acid analogs?

BMC Res Notes 2019 Apr 2;12(1):197. Epub 2019 Apr 2.

Institute of Organic Chemistry, Clausthal University of Technology, Leibnizstr. 6, 38678, Clausthal-Zellerfeld, Germany.

Objective: A synthetic pathway to γ-hydroxy-α-(arylmethyl)carboxylic acids starting from α-angelica lactone and γ-butyrolactone was investigated. These γ-hydroxycarboxylic acids resemble structural motifs of lactic acid and amino acids. The possibility of cocondensation with lactic acid towards functionalized poly(lactic acid)s was analyzed. Read More

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http://dx.doi.org/10.1186/s13104-019-4232-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444536PMC

Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan.

BMC Res Notes 2019 Apr 2;12(1):202. Epub 2019 Apr 2.

Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.

Objective: To assess the clinical presentation and hematological profile among young (≤ 55 years) and old (> 55 years) chronic lymphocytic leukemia patients in Sudan.

Result: In the present cross-sectional descriptive study, out of 110 cases studied, among them 31 (28.2%) were young (≤ 55 years) patients with mean age 48 years, and 79 (71. Read More

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http://dx.doi.org/10.1186/s13104-019-4239-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446286PMC
April 2019
3 Reads

Protocol for geolocating rural villages of women in Liberia utilizing a maternity waiting home.

BMC Res Notes 2019 Apr 2;12(1):196. Epub 2019 Apr 2.

University of Michigan School of Nursing, 400 N. Ingalls, Room 3237, Ann Arbor, USA.

Objective: Geospatial data are used by health systems and researchers to understand disease burdens, trace outbreaks, and allocate resources, however, there are few well-documented protocols for collecting and analyzing geographic information systems data in rural areas of low- and middle-income countries. Even with the proliferation of spatial technologies such as Open Street Map and Google Maps, basic geographic data-such as village locations-are not widely available in many countries in sub-Saharan Africa. The purpose of this paper is to report a step-wise protocol, using geographic information system techniques and tools, developed to collect and analyze the type of spatial data necessary to calculate the distance between rural villages and maternity waiting homes located near rural primary healthcare facilities in Bong County, Liberia. Read More

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http://dx.doi.org/10.1186/s13104-019-4224-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444816PMC

Prevalence of glucose-6-phosphate dehydrogenase deficiency in Cameroonian blood donors.

BMC Res Notes 2019 Apr 2;12(1):195. Epub 2019 Apr 2.

Division of Global Pediatrics, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

Objective: Deficiency in G6PD is the most common enzymopathy worldwide. It is frequently found in individuals of African descent in whom it can lead to hemolytic crises triggered by the use of certain antimalarial medications and infection. The prevalence of G6PD deficiency and its contribution to morbidity in West Africa is under-studied. Read More

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http://dx.doi.org/10.1186/s13104-019-4226-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444568PMC
April 2019
2 Reads

Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis.

BMC Res Notes 2019 Apr 2;12(1):200. Epub 2019 Apr 2.

Novartis Pharma AG, Basel, Switzerland.

Objective: Therapeutic effects of focal adhesion kinase (FAK) inhibition using a small molecule inhibitor was evaluated in apolipoprotein E (apoE) knockout (KO) and low-density lipoprotein receptor (LDLr) KO mouse atherosclerosis models.

Results: The prevention trial consisted of an 8-week treatment with an FAK inhibitor concurrent treatment with a high fat (HF)/high cholesterol (HC) diet. The intervention trial consisted of 6- and 8-week treatment after 6- and 8-week pre-loading, respectively, of a HF/HC diet in apoE KO and LDLr KO mice, respectively. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4220-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446301PMC
April 2019
6 Reads

Association of bullying experiences with depressive symptoms and psychosocial functioning among school going children and adolescents.

BMC Res Notes 2019 Apr 2;12(1):198. Epub 2019 Apr 2.

Natchaug Hospital, 189 Storrs Rd, Mansfield Center, CT, 06250, USA.

Objectives: We examined the association of bullying experiences with depressive symptoms and psychosocial functioning among children and adolescents in rural Pakistan. A total of 452 school-going children in Nawabshah, Pakistan were conveniently interviewed to assess rates of bullying experiences and severity of depressive symptoms. Depressive symptoms were assessed using the Patient Health Questionnaire for Adolescents. Read More

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http://dx.doi.org/10.1186/s13104-019-4236-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444870PMC
April 2019
7 Reads

Trend analysis of malaria prevalence in Halaba special district, Southern Ethiopia.

BMC Res Notes 2019 Mar 29;12(1):190. Epub 2019 Mar 29.

Department of Microbial, Cellular and Molecular Biology (Infection Biology Stream), College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Objective: The study aimed to determine the prevalence of malaria in Halaba special district, Southern Ethiopia, from 2013 to 2017.

Results: Of a total 583,668 malaria suspected cases examined during the study period, 55,252 (9.5%) were microscopically confirmed to be positive for malaria, at the rate of 27,712 (50. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4215-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441312PMC
March 2019
3 Reads

microRNA-21 expressions impact on liver fibrosis in biliary atresia patients.

BMC Res Notes 2019 Mar 29;12(1):189. Epub 2019 Mar 29.

Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia.

Objective: Biliary atresia (BA) is the most common cause of neonatal jaundice, characterized by progressive and rapid liver fibrosis. Recent studies have shown that microRNAs (miRNAs) contribute to the liver fibrogenesis. We investigated the miRNA-21 impact in liver fibrogenesis in Indonesian BA patients. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-019-4227-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441216PMC
March 2019
2 Reads

Intestinal parasitic infections among public and private schoolchildren of Kathmandu, Nepal: prevalence and associated risk factors.

BMC Res Notes 2019 Mar 29;12(1):192. Epub 2019 Mar 29.

Shi-Gan International College of Science and Technology, Affiliated to Tribhuvan University, Kathmandu, Nepal.

Objective: Intestinal parasitic infections (IPIs) are a major cause of morbidity among children in developing countries. Investigation about the etiological agents and socio-ecological pattern of the infection would help to design better preventive strategy. The previous studies reported high prevalence of IPIs among schoolchildren of Nepal. Read More

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http://dx.doi.org/10.1186/s13104-019-4225-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441203PMC

Unexpected insertion of carrier DNA sequences into the fission yeast genome during CRISPR-Cas9 mediated gene deletion.

BMC Res Notes 2019 Mar 29;12(1):191. Epub 2019 Mar 29.

School of Biology, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.

Objectives: The fission yeast Schizosaccharomyces pombe is predicted to encode ~ 200 proteins of < 100 amino acids, including a number of previously uncharacterised proteins that are found conserved in related Schizosaccharomyces species only. To begin an investigation of the function of four of these so-called microproteins (designated Smp1-Smp4), CRISPR-Cas9 genome editing technology was used to delete the corresponding genes in haploid fission yeast cells.

Results: None of the four microprotein-encoding genes was essential for viability, meiosis or sporulation, and the deletion cells were no more sensitive to a range of cell stressors than wild-type, leaving the function of the proteins unresolved. Read More

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http://dx.doi.org/10.1186/s13104-019-4228-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441176PMC

Novel binding partners for Prenylated Rab Acceptor 1 identified by a split-ubiquitin yeast two-hybrid screen.

BMC Res Notes 2019 Mar 29;12(1):188. Epub 2019 Mar 29.

Biology Department, Saint Louis University, Macelwane Hall, 3507 Laclede Ave, St. Louis, MO, 63103, USA.

Objective: Prenylated Rab Acceptor 1 (PRA1) is a transmembrane protein localized to the early secretory pathway. It has been found to interact with an array of Rab GTPases, leading to its hypothesized function in the recycling of Rab GTPases. However, all previous strategies used to screen for novel interacting partners have utilized a classic yeast two-hybrid approach that requires both bait and its potential binding partners to be cytosolic proteins. Read More

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http://dx.doi.org/10.1186/s13104-019-4219-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441142PMC

Socioeconomic inequality in stunting among under-5 children in Ethiopia: a decomposition analysis.

BMC Res Notes 2019 Mar 29;12(1):184. Epub 2019 Mar 29.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Ethiopia bears a high stunting burden. However, there is a paucity of evidence on the socioeconomic inequalities of stunting in Ethiopia. Thus, this study was aimed to determine the degree of socioeconomic inequality in stunting and decompose it to the social determinants of stunting. Read More

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http://dx.doi.org/10.1186/s13104-019-4229-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440115PMC

Prevention care for secondary health conditions among people living with spinal cord injuries: research protocol.

BMC Res Notes 2019 Mar 28;12(1):179. Epub 2019 Mar 28.

Department of Physiotherapy, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Johannesburg, 2193, South Africa.

Objective: People living with spinal cord injuries are at a high risk to experience preventable secondary health conditions in their lifetime, which can lead to rehospitalisation and death. Given the fact that spinal cord injury is a long term disability requiring on-going care, there is need to strengthen prevention of secondary health conditions. This study aims to establish factors influencing prevention care for secondary health conditions among people living with spinal cord injuries in a metropolitan area in order to develop a prevention model of care. Read More

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http://dx.doi.org/10.1186/s13104-019-4202-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437883PMC

Factors affecting healthcare utilization for low back pain among nurses in Gondar town, northwest Ethiopia, 2018: a cross-sectional study.

BMC Res Notes 2019 Mar 29;12(1):185. Epub 2019 Mar 29.

Department of Environmental and Occupational Health and Safety, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, P.O.Box 196, Gondar, Ethiopia.

Objective: The objective of this study was to investigate level and factors affecting healthcare utilization for low back pain (LBP) among nurses in Gondar town, Ethiopia. A healthcare-based cross-sectional study was conducted from March to April 2018. We included 422 nurses using stratified sampling technique. Read More

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http://dx.doi.org/10.1186/s13104-019-4231-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439990PMC
March 2019
1 Read

Ribosomal/nucleolar stress induction regulates tert-Butyl hydroperoxide (tBHP) mediated oxidative stress in Anopheles gambiae midguts.

BMC Res Notes 2019 Mar 29;12(1):182. Epub 2019 Mar 29.

Department of Health and Biomedical Sciences, Nelson Mandela-African Institution of Science and Technology, Tengeru, Arusha, 23302, Tanzania.

Objective: A fundamental understanding of redox homeostasis in Anopheles gambiae midgut cells under different oxidative conditions is missing. Such knowledge can aid in the development of new malaria transmission-blocking strategies aimed at disrupting natural homeostatic processes in the mosquito during Plasmodium parasite uptake (i.e. Read More

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http://dx.doi.org/10.1186/s13104-019-4196-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440166PMC