1,877 results match your criteria BMC Pulmonary Medicine[Journal]


Treatment patterns, healthcare resource utilization, and costs among patients with idiopathic pulmonary fibrosis treated with antifibrotic medications in US-based commercial and Medicare Supplemental claims databases: a retrospective cohort study.

BMC Pulm Med 2020 Jul 11;20(1):188. Epub 2020 Jul 11.

IBM Watson Health, 75 Binney Street, Cambridge, MA, 02142, USA.

Background: Pirfenidone and nintedanib are antifibrotic therapies which slow disease progression in idiopathic pulmonary fibrosis (IPF), an irreversible, progressive lung disease with poor prognosis. We compared adherence, persistence, and healthcare costs between patients initiating one of the two therapies.

Methods: We used the IBM Watson Health Commercial and Medicare Supplemental claims databases to select patients with IPF with ≥1 pharmacy claim for pirfenidone or nintedanib between 10/1/2014 and 6/30/2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01224-5DOI Listing

A young male with chronic nonproductive cough diagnosed with blastomycosis in China: a case report.

BMC Pulm Med 2020 Jul 11;20(1):189. Epub 2020 Jul 11.

Department of Respiratory, Shanghai East Hospital, Affiliated to Tongji University, No.150 Jimo Road, Pudong District, Shanghai, 200020, People's Republic of China.

Background: Blastomycosis is a fungal infectious disease prevalent in North America and rarely reported in Asia. Misdiagnosis of malignancy and other infectious diseases were reported.

Case Presentation: A 24-years-old male patient presented with chronic non-productive cough of 4 months duration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01225-4DOI Listing

Conventional Computed Tomographic Calcium Scoring vs full chest CTCS for lung cancer screening: a cost-effectiveness analysis.

BMC Pulm Med 2020 Jul 6;20(1):187. Epub 2020 Jul 6.

Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Background: Conventional CTCS images the mid/lower chest for coronary artery disease (CAD). Because many CAD patients are also at risk for lung malignancy, CTCS often discovers incidental pulmonary nodules (IPN). CTCS excludes the upper chest, where malignancy is common. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01221-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336401PMC

Rapid disease progress in a PVOD patient carrying a novel EIFAK mutation: a case report.

BMC Pulm Med 2020 Jul 6;20(1):186. Epub 2020 Jul 6.

Department of Cardiology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.

Background: Pulmonary veno-occlusive disease (PVOD) and pulmonary arterial hypertension (PAH) share an overlapping disease phenotype. Hence it is necessary to distinguish them.

Case Presentation: Our 14-year-old female patient admitted with progressive shortness of breath, dizziness, and fatigue even after minimal physical activity was clinically suspected for PAH, based on her previous history. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01186-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336641PMC

Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p.

BMC Pulm Med 2020 Jul 2;20(1):185. Epub 2020 Jul 2.

Department of Respiratory Medicine, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, No. 16 Nanwu Road, Guicheng, Nanhai District, Foshan City, Guangdong Province, 528200, P.R. China.

Background: Long noncoding RNA POU class 3 homeobox 3 (POU3F3) is upregulated in esophageal squamous-cell carcinomas. The present study aimed to investigate the role of POU3F3 in non-small cell lung cancer (NSCLC).

Methods: A total of 80 patients with NSCLC (adenocarcinoma) admitted by Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine between May 2016 and May 2018 were enrolled in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01218-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331167PMC

Real-life experience with benralizumab during 6 months.

BMC Pulm Med 2020 Jun 29;20(1):184. Epub 2020 Jun 29.

Pneumology Department, Hospital Universitario Virgen de la Victoria, Campus de Teatinos s/n, 29010, Málaga, Spain.

Background: Benralizumab is a monoclonal antibody that binds to the human interleukin-5 (IL-5) receptor (IL-5R), thereby preventing IL-5 from binding to its receptor and inhibiting differentiation and maturation of eosinophils in the bone marrow. Because of its recent marketing approval, sufficient real-life evidence is lacking to confirm the efficacy and safety data from clinical trials. The purpose of this study was to evaluate the efficacy and safety of benralizumab for the treatment of severe refractory eosinophilic asthma in a real-world cohort of patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01220-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325276PMC

Transbronchial lung cryobiopsy may be of value for nonresolving acute respiratory distress syndrome: case series and systematic literature review.

BMC Pulm Med 2020 Jun 29;20(1):183. Epub 2020 Jun 29.

Department of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital; National Clinical Research Centre for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, 2 Yinghuayuan East Street, Chaoyang District, Beijing, 100029, China.

Background: Identification of pathologic features is helpful for the management of nonresolving acute respiratory distress syndrome (ARDS). Transbronchial lung cryobiopsy (TBLC) is a novel biopsy technique that may have comparable utility to surgical biopsy. The aim of this study was to assess the value of TBLC in patients with nonresolving ARDS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01203-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322907PMC

The association between cystatin C and COPD: a meta-analysis and systematic review.

BMC Pulm Med 2020 Jun 26;20(1):182. Epub 2020 Jun 26.

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Xi'an, 710061, Shaanxi, People's Republic of China.

Background: In recent years, many studies have discovered that cystatin C (Cys C) may play an important role in respiratory diseases, especially in chronic obstructive pulmonary disease (COPD). However, the findings of these studies were inconsistent. This systematic review and meta-analysis aimed to assess the relationship between serum Cys C and COPD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01208-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318461PMC

A case of torsades de pointes induced by the third-generation EGFR-TKI, osimertinib combined with moxifloxacin.

BMC Pulm Med 2020 Jun 24;20(1):181. Epub 2020 Jun 24.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.

Background: Torsade de pointes (TdP) is a malignant arrhythmia that can be induced by QT internal prolongation due to a variety of factors. Here we report an elderly patient with advanced non-small cell lung cancer (NSCLC) had sudden TdP during hospitalization, which was caused by multiple factors such as osimertinib, moxifloxacin and patient self-factors.

Case Presentation: An 85-year-old man with advanced NSCLC with brain andbone metastasis was initially treated with gefitinib targeted therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01217-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313192PMC

Prognostic role of the preoperative neutrophil-to-lymphocyte ratio and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism.

BMC Pulm Med 2020 Jun 24;20(1):180. Epub 2020 Jun 24.

Department of Orthopedic, Affiliated Hospital of Chengde Medical University, Chengde, China.

Background: This retrospective study aimed to investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism (PAPE).

Methods: We retrospectively reviewed the medical records of 101 patients with PAPE admitted from September 1, 2012, to March 31, 2019. The characteristics, surgical information, admission examination data and mortality within 30 days after PAPE were obtained from our electronic medical recording system and follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01216-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315518PMC

Lung and general health effects of Toll-like receptor-4 (TLR4)-interacting SPA4 peptide.

BMC Pulm Med 2020 Jun 23;20(1):179. Epub 2020 Jun 23.

Division of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.

Background: A surfactant protein-A-derived peptide, which we call SPA4 peptide (amino acids: GDFRYSDGTPVNYTNWYRGE), alleviates lung infection and inflammation. This study investigated the effects of intratracheally administered SPA4 peptide on systemic, lung, and health parameters in an outbred mouse strain, and in an intratracheal lipopolysaccharide (LPS) challenge model.

Methods: The outbred CD-1 mice were intratracheally administered with incremental doses of SPA4 peptide (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01187-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310322PMC
June 2020
2.489 Impact Factor

Six-minute walking distance in healthy Chinese people older than 60 years.

BMC Pulm Med 2020 Jun 22;20(1):177. Epub 2020 Jun 22.

Department of General Practice, Zhejiang Hospital, Hangzhou, Zhe Jiang, China.

Background: The six-minute walking test (6MWT) is a tool that plays a key role in evaluating the functional exercise capacity, prognosis and evaluation of treatment response of patients with various cardiopulmonary diseases. However, standard reference equations are currently unavailable for the six-minute walking distance (6MWD) for people aged 60-85 years in China. The purpose of this study was to 1) measure the 6MWD of healthy Chinese people aged 60-85 years, 2) establish reference equations for predicting the 6MWD, and 3) compare our reference equations with equations reported in previously published studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01211-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310198PMC

Influence of age on the diagnostic accuracy of soluble biomarkers for tuberculous pleural effusion: a post hoc analysis.

BMC Pulm Med 2020 Jun 22;20(1):178. Epub 2020 Jun 22.

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti Nanlu, Chaoyang District, Beijing, 100020, China.

Background: Accurately diagnosing pleural effusion is a frequent and significant problem in clinical practice. Combining pleural biomarkers with patients' age may be a valuable method for diagnosing TPE. We sought to evaluate the influence of age on diagnostic values of pleural adenosine deaminase (ADA), interferon-gamma (IFN-γ), and interleukin 27 (IL-27) for tuberculous pleural effusion (TPE). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01219-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310016PMC
June 2020
2.489 Impact Factor

Thoracic perfusion of recombinant mutant human tumor necrosis factor (rmhTNF) can be considered as a good adjunct in the treatment of malignant pleural effusion caused by lung cancer.

BMC Pulm Med 2020 Jun 18;20(1):175. Epub 2020 Jun 18.

Department of Respiration, Jining NO.1 People's Hospital, Jining, 272011, Shandong Province, China.

Background: Tumor necrosis factor (TNF) has been investigated to be correlated with the occurrence and progression of lung cancer. This investigation was to assess the efficacy and safety of recombinant mutant human tumor necrosis factor (rmhTNF) for controlling malignant pleural effusion (MPE) through thoracic perfusion.

Methods: Through searching from MEDLINE, Web of Science, EMBASE, Cochrance Library, OVID and China National Knowledge Infrastructure (CNKI), a total of 12 studies with 694 patients were included in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01210-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301477PMC

Data driven decision making to characterize clinical personas of parents of children with cystic fibrosis: a mixed methods study.

BMC Pulm Med 2020 Jun 18;20(1):174. Epub 2020 Jun 18.

Haslinger Family Pediatric Palliative Care Center, Akron Children's Hospital, Akron, OH, USA.

Background: Beginning at a young age, children with cystic fibrosis (CF) embark on demanding care regimens that pose challenges to parents. We examined the extent to which clinical, demographic and psychosocial features inform patterns of adherence to pulmonary therapies and how these patterns can be used to develop clinical personas, defined as aspects of adherence barriers that are presented by parents and/or perceived by clinicians, in order to enhance personalized CF care delivery.

Methods: We undertook an explanatory sequential mixed-methods study consisting of i) multivariate clustering to create clusters corresponding to parental adherence patterns (quantitative phase); ii) parental participant interviews to create clinical personas interpreted from clustering (qualitative phase). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01202-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301999PMC

Exploring characteristics of COPD patients with clinical improvement after integrated disease management or usual care: post-hoc analysis of the RECODE study.

BMC Pulm Med 2020 Jun 18;20(1):176. Epub 2020 Jun 18.

Department of Public Health and Primary Care, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, Netherlands.

Background: The cluster randomized controlled trial on (cost-)effectiveness of integrated chronic obstructive pulmonary disease (COPD) management in primary care (RECODE) showed that integrated disease management (IDM) in primary care had no effect on quality of life (QOL) in COPD patients compared with usual care (guideline-supported non-programmatic care). It is possible that only a subset of COPD patients in primary care benefit from IDM. We therefore examined which patients benefit from IDM, and whether patient characteristics predict clinical improvement over time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01213-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302138PMC
June 2020
2.489 Impact Factor

Changing clinical characteristics of non-cystic fibrosis bronchiectasis in children.

BMC Pulm Med 2020 Jun 16;20(1):172. Epub 2020 Jun 16.

Division of Pediatric Pulmonology, Marmara University, School of Medicine, Istanbul, Turkey.

Background: The prevalence of non-cystic fibrosis (CF) bronchiectasis is increasing in both developed and developing countries in recent years. Although the main features remain similar, etiologies seem to change. Our aim was to evaluate the clinical and laboratory characteristics of our recent non-CF bronchiectasis patients and to compare these with our historical cohort in 2001. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01214-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298950PMC

Hepatitis in children with tuberculosis: a case report and review of the literature.

BMC Pulm Med 2020 Jun 16;20(1):173. Epub 2020 Jun 16.

Division of Pediatric Infectious Diseases, Nationwide Children's Hospital, Columbus, OH, USA.

Background: Hepatitis in young children with tuberculosis (TB) outside miliary TB is not well described and represents a challenge because of the hepatotoxicity associated with first-line anti-TB treatment.

Case Presentation: We report an antibiotic naïve 13-month-old male from Nepal with pulmonary TB and hepatitis, who improved after TB treatment. We also performed a literature review for TB-associated hepatitis in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01215-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298953PMC

Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study.

BMC Pulm Med 2020 Jun 16;20(1):171. Epub 2020 Jun 16.

National Heart and Lung Institute, Imperial College London, London, UK.

Background: Low lung function has been associated with increased body mass index (BMI). The aim of this study was to investigate whether the effect of BMI on lung function is mediated by DNA methylation.

Methods: We used individual data from 285,495 participants in four population-based cohorts: the European Community Respiratory Health Survey, the Northern Finland Birth Cohort 1966, the Swiss Study on Air Pollution and Lung Disease in Adults, and the UK Biobank. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01212-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298775PMC
June 2020
2.489 Impact Factor

Cancer development in patients with COPD: a retrospective analysis of the National Health Insurance Service-National Sample Cohort in Korea.

BMC Pulm Med 2020 Jun 15;20(1):170. Epub 2020 Jun 15.

Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Worldcup road 164, Suwon, Gyeonggi-do, 16499, South Korea.

Background: COPD is a well-known risk factor for lung cancer, independent of smoking behavior. By investigating the retrospective National Health Insurance Service-National Sample Cohort (NHIS-NSC) in Korea, this study attempted to prove the hypothesis that COPD is a risk factor for major cancers developing outside of the lungs. We also aimed to investigate the environmental factors associated with the development of lung cancer in COPD patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01194-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296952PMC
June 2020
2.489 Impact Factor

Empirical prescribing of penicillin G/V reduces risk of readmission of hospitalized patients with community-acquired pneumonia in Norway: a retrospective observational study.

BMC Pulm Med 2020 Jun 15;20(1):169. Epub 2020 Jun 15.

Department of Pharmacy, Faculty of Health Sciences, UiT - The Arctic University of Norway, N-9037, Tromsø, Norway.

Background: Norwegian guideline recommendations on first-line empirical antibiotic prescribing in hospitalised patients with community-acquired pneumonia (CAP) are penicillin G/V in monotherapy, or penicillin G in combination with gentamicin (or cefotaxime) in severely ill patients. The aim of this study was to explore how different empirical antibiotic treatments impact on length of hospital stay (LOS) and 30-day hospital readmission. A secondary aim was to describe median intravenous- and total treatment duration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294665PMC

How does the EQ-5D-5L perform in asthma patients compared with an asthma-specific quality of life questionnaire?

BMC Pulm Med 2020 Jun 13;20(1):168. Epub 2020 Jun 13.

Institute of Health Economics and Health Care Management, Helmholtz Zentrum München (GmbH) - German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

Background: Asthma patients experience impairments in health-related quality of life (HRQL). Interventions are available to improve HRQL. EQ-5D-5L is a common generic tool used to evaluate health interventions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01205-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293124PMC

An 8 week open-label interventional multicenter study to explore the lung clearance index as endpoint for clinical trials in cystic fibrosis patients ≥8 years of age, chronically infected with Pseudomonas aeruginosa.

BMC Pulm Med 2020 Jun 12;20(1):167. Epub 2020 Jun 12.

Novartis Pharma GmbH, Nürnberg, Germany.

Background: Forced expiratory volume in 1 second (FEV) is the only parameter currently recognized as a surrogate endpoint in cystic fibrosis (CF) trials. However, FEV is relatively insensitive to changes in the small airways of patients with milder lung disease. This pilot study aimed to explore the lung clearance index (LCI) as a marker for use in efficacy trials with inhaled antibiotics in CF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01201-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291662PMC

Procalcitonin and C-reactive protein perform better than the neutrophil/lymphocyte count ratio in evaluating hospital acquired pneumonia.

BMC Pulm Med 2020 Jun 11;20(1):166. Epub 2020 Jun 11.

Department of Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.

Background: The relationship between biomarkers and hospital-acquired pneumonia (HAP) is understudied, especially in severe cases admitted to the intensive care unit (ICU). Compared with community-acquired pneumonia (CAP), HAP might have different traits regarding biomarkers due to the previous history in hospitals.

Methods: A total of 593 adult patients were enrolled in this retrospective cohort study to determine the neutrophil/lymphocyte count ratio (NLCR), procalcitonin (PCT), C-reactive protein (CRP) and serum lactate level upon admission to the ICU. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01207-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289235PMC

Hippocratic concepts of acute and urgent respiratory diseases still relevant to contemporary medical thinking and practice: a scoping review.

BMC Pulm Med 2020 Jun 10;20(1):165. Epub 2020 Jun 10.

Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.

Background: The collected works of Hippocrates were searched for concepts on the diagnosis, prognosis, and treatment of acute and urgent respiratory diseases, with the objective to trace their origins in the Hippocratic Collection.

Methods: A scoping review was performed to map out key concepts of acute and severe respiratory diseases in the entire Hippocratic Collection. The digital library Thesaurus Lingua Graeca (TLG) was researched for references in the entire Hippocratic Collection regarding the epidemiology, pathophysiology, prognosis, diagnosis and treatment of acute respiratory diseases; then, the relevant texts were studied in their English translation by the Loeb Classical Library. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01193-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288510PMC

Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.

BMC Pulm Med 2020 Jun 9;20(1):164. Epub 2020 Jun 9.

Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Tlalpan 4502, CP 14080, Ciudad de Mexico, Mexico.

Background: Several lung structural and functional abnormalities may occur associated with aging, including emphysema. In this study, we evaluated the frequency and risk factors associated with emphysema in respiratory asymptomatic individuals enrolled in our Lung Aging Program. From a cohort of 687 subjects, we found by high-resolution computed tomography (HRCT) 29 individuals (4%) with emphysematous changes that were compared with 87 controls (3:1) randomly selected from the same cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01204-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285611PMC
June 2020
2.489 Impact Factor

Findings from a pilot randomised trial of a social network self-management intervention in COPD.

BMC Pulm Med 2020 Jun 8;20(1):162. Epub 2020 Jun 8.

NIHR Wessex CLARHC, Southampton, UK.

Background: Self-Management Support (SMS), refers to the actions taken by individuals to recognise and manage their own health. It is increasingly recognised that individuals with chronic obstructive pulmonary disease (COPD) require additional support with their Self-management. Emerging evidence suggests that the use of a social network intervention can improve health outcomes and increase quality of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-1130-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278059PMC

MIR205HG acts as a ceRNA to expedite cell proliferation and progression in lung squamous cell carcinoma via targeting miR-299-3p/MAP3K2 axis.

BMC Pulm Med 2020 Jun 8;20(1):163. Epub 2020 Jun 8.

Three Wards of Outpatient Service, Wuhan Jin Yin Tan Hospital, No.1 Yintan Road, Dongxihu District, Wuhan, 433013, Hubei, China.

Introduction: Long noncoding RNAs (lncRNAs) have been associated with many types of cancers, but their molecular mechanisms in lung squamous cell carcinoma (LUSC) have not been fully studied. Therefore, the current study investigated the regulation role of microRNA-205 host gene (MIR205HG) in LUSC and recognized the target genes managed by this lncRNA.

Methods: MIR205HG expression was assessed by the quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-1174-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278044PMC

Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial.

BMC Pulm Med 2020 Jun 5;20(1):160. Epub 2020 Jun 5.

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin-kawaracho, Sakyo, Kyoto, 606-8507, Japan.

Background: Ceftriaxone (CTRX) and ampicillin/sulbactam (ABPC/SBT) are recommended by various guidelines as the first-line antibiotics for community-acquired pneumonia (CAP). However, which of these antibiotics is more effective for treating non-aspiration CAP remains unclear.

Methods: This study was a prospective, single-center, open-label, quasi-randomized controlled trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01198-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275365PMC

Pulmonary cryptococcosis coexisting with central type lung cancer in an immuocompetent patient: a case report and literature review.

BMC Pulm Med 2020 Jun 5;20(1):161. Epub 2020 Jun 5.

City Hope National Medical Center, Duarte, California, USA.

Background: Pulmonary Cryptococcosis is a common fungal infection mainly caused by Cryptococcus neoformans/C.gattii species in immunocompromised patients. Cases of pulmonary cryptococcosis in patients with normal immune function are increasingly common in China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01200-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275487PMC

Management of initial colonisations with Burkholderia species in France, with retrospective analysis in five cystic fibrosis Centres: a pilot study.

BMC Pulm Med 2020 Jun 5;20(1):159. Epub 2020 Jun 5.

CRCM pédiatrique, Service de Pneumo-Allergologie pédiatrique, Hôpital des Enfants, Centre Hospitalier Universitaire de Toulouse, 330 avenue de Grande-Bretagne - TSA 40031, 31059, Toulouse cedex 9, France.

Background: Whereas Burkholderia infections are recognized to impair prognosis in cystic fibrosis (CF) patients, there is no recommendation to date for early eradication therapy. The aim of our study was to analyse the current management of initial colonisations with Burkholderia cepacia complex (BCC) or B. gladioli in French CF Centres and its impact on bacterial clearance and clinical outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01190-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275364PMC

Combination of 1.1 mm flexible cryoprobe with conventional guide sheath and therapeutic bronchoscope in biopsy of apical upper lobe solitary pulmonary nodule.

BMC Pulm Med 2020 Jun 3;20(1):158. Epub 2020 Jun 3.

Division of Respiratory Medicine, Department of Medicine, Sarawak General Hospital, Ministry of Health, Kuching, Sarawak, Malaysia.

Background: Lung cancer is frequently situated peripherally in the upper lobes of the lung. Acquiring adequate tissue from this difficult-to-reach area remains a challenge. Transbronchial cryobiopsy (TBCB) has the ability to acquire larger specimens, but the rigidity of the standard 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01199-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269002PMC

Recovery from hypoxemia and Hypercapnia following noninvasive pressure support ventilation in a patient with statin-associated necrotizing myopathy: a case report.

BMC Pulm Med 2020 Jun 3;20(1):156. Epub 2020 Jun 3.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.

Background: Statin-associated necrotizing myopathy (SANM) is a rare autoimmune disorder caused by administration of statins. SANM is characterized by weakness due to necrosis and regeneration of myofibers. Here we report the first case of SANM with acute respiratory failure treated with noninvasive pressure support ventilation in addition to immunosuppressants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01195-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268346PMC

Treatment of superimposed preeclampsia on chronic hypertension in a twin pregnancy with automatic continuous positive airway pressure: a case report.

BMC Pulm Med 2020 Jun 3;20(1):157. Epub 2020 Jun 3.

Department of Obstetrics and Gynecology, CHA Bundang Medical Center, 59 Yatap-ro, Seongnam, 13496, Republic of Korea.

Background: Obstructive sleep apnoea (OSA) is related with adverse pregnancy outcomes, including preeclampsia. However, there are small studies about treatment of OSA with automatic continuous positive airway pressure (CPAP) in adverse obstetric outcomes.

Case Presentation: We introduce a case of 34 year old twin pregnant woman diagnosed with superimposed preeclampsia on chronic hypertension at 28 + 1/7 weeks of gestation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01196-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268687PMC

Clinical characteristics and organ system involvement in sarcoidosis: comparison of the University of Minnesota Cohort with other cohorts.

BMC Pulm Med 2020 Jun 1;20(1):155. Epub 2020 Jun 1.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Univesity of Minnesota Medical School, Minneapolis, USA.

Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Clinical cohort studies of different populations are important to understand the high variability in clinical presentation and disease course of sarcoidosis. The aim of the study is to evaluate clinical characteristics, including organ involvement, pulmonary function tests, and laboratory parameters, in a sarcoidosis cohort at the University of Minnesota. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01191-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268634PMC

Changes in REVEAL risk score in patients with pulmonary arterial hypertension treated with macitentan in clinical practice: results from the PRACMA study.

BMC Pulm Med 2020 Jun 2;20(1):154. Epub 2020 Jun 2.

Pulmonary Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background: Macitentan is a dual endothelin receptor antagonist indicated for the long-term treatment of pulmonary arterial hypertension (PAH). We evaluated the change over time in REVEAL risk score in incident and prevalent patients receiving macitentan for the first time.

Methods: Retrospective, observational study including adult patients with idiopathic/heritable PAH or PAH associated with connective tissue disorders or congenital heart disease treated with macitentan for ≥6-month follow-up in Spain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01197-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265251PMC

LncRNA WTAPP1 promotes cancer cell invasion and migration in NSCLC by downregulating lncRNA HAND2-AS1.

BMC Pulm Med 2020 May 30;20(1):153. Epub 2020 May 30.

Department of Thoracic Surgery, The Second Hospital of Jilin University, No.218 Ziqiang Street, Changchun City, Jilin Province, 130041, People's Republic of China.

Background: Long non-coding RNA (lncRNA) Wilms Tumor 1 Associated Protein Pseudogene 1 (WTAPP1) has been reported to be a critical player in the angiogenesis and migration of endothelial progenitor cells, while its involvement in cancer biology remains unknown. This study was carried out to investigate the role of WTAPP1 in non-small cell lung cancer (NSCLC).

Methods: The expression of WTAPP1 and lncRNA HAND2 Antisense RNA 1 (HAND2-AS1) in plasma and tissues from NSCLC patients was detected by qRT-PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01180-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260856PMC

Health-related quality of life associates with change in FEV in COPD: results from the COSYCONET cohort.

BMC Pulm Med 2020 May 29;20(1):148. Epub 2020 May 29.

Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, GmbH - German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.

Background: Forced expiratory volume in one second (FEV) characterizes the pathophysiology of COPD and different trajectories of FEV decline have been observed in patients with COPD (e.g. gradual or episodic). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-1147-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257512PMC

MiR-449b-5p targets lncRNA PSMG3-AS1 to suppress cancer cell proliferation in lung adenocarcinoma.

BMC Pulm Med 2020 May 29;20(1):152. Epub 2020 May 29.

Department of Pathology, the 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), NO.789 East Suzhou Street, New Urban Area, Urumqi, 830000, Xinjiang, China.

Background: PSMG3-AS1 has been characterized as an oncogenic lncRNA in breast cancer, while its role in other cancers is unknown. This study investigated the role of PSMG3-AS1 in lung adenocarcinoma (LUAD).

Methods: This study included 64 LUAD patients (42 males and 22 females) who were enrolled between May 2012 and May 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01189-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260832PMC
May 2020
2.489 Impact Factor

Clinical characteristics and survival of Chinese patients diagnosed with pulmonary arterial hypertension who carry BMPR2 or EIF2KAK4 variants.

BMC Pulm Med 2020 May 29;20(1):150. Epub 2020 May 29.

State Key Laboratory of Cardiovascular Disease, Center of Pulmonary Vascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, North Lishi Road, Xicheng District, No.167, Beijing, China.

Background: Variants in the gene encoding bone morphogenetic protein receptor type II (BMPR2) are the most common genetic cause of pulmonary arterial hypertension (PAH), whereas biallelic variants in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF2AK4) are described in pulmonary veno-occlusive disease/pulmonary capillary haemangiomatosis (PVOD/PCH). Racial background may influence the clinical characteristics of patients diagnosed with PAH or PVOD/PCH. Here, we compared the clinical characteristics and survival between patients with BMPR2 variants or EIF2AK4 variants in a Chinese population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01179-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257189PMC

Recurrent pneumothorax and intrapulmonary cavitary lesions in a male patient with vascular Ehlers-Danlos syndrome and a novel missense mutation in the COL3A1 gene: a case report.

BMC Pulm Med 2020 May 29;20(1):149. Epub 2020 May 29.

Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, Zhejiang, 325000, People's Republic of China.

Background: Vascular Ehlers-Danlos syndrome (vEDS) is a rare autosomal dominant hereditary collagen disease caused by a defect or deficiency in the pro-α1 chain of type III procollagen encoded by the COL3A1 gene. Patients with vEDS rarely present with multiple pneumothoraces. The clinical features of this disease are not familiar to clinicians and are easily missed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-1164-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257228PMC

Evaluation of time courses of agreement between minutely obtained transcutaneous blood gas data and the gold standard arterial data from spontaneously breathing Asian adults, and various subgroup analyses.

BMC Pulm Med 2020 May 29;20(1):151. Epub 2020 May 29.

Intensive Care Unit, University of Minnesota, Minneapolis, MN, USA.

Background: Usual clinical practice for arterial blood gas analysis (BGA) in conscious patients involves a one-time arterial puncture to be performed after a resting period of 20-30 min. The aim of this study was to evaluate the use of transcutaneous BGA for estimating this gold standard arterial BGA.

Methods: Spontaneously breathing Asian adults (healthy volunteers and respiratory patients) were enrolled (n = 295). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01184-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257137PMC

Clinical implication of plasma exchange on life-threatening antineutrophil cytoplasmic antibody-associated vasculitis.

BMC Pulm Med 2020 May 28;20(1):147. Epub 2020 May 28.

Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: We assessed the rate of and predictors for all-cause mortality in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) receiving plasma exchange (PLEX) and evaluated the survival benefit of PLEX for diffuse alveolar haemorrhage (DAH) between AAV patients receiving PLEX and those not receiving PLEX.

Methods: We retrospectively reviewed the medical records of 212 patients with AAV. Demographic, clinical and laboratory data at the time of PLEX were collected from nine patients receiving PLEX, six of whom had DAH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01181-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257153PMC

Comparison of sputum induction and bronchoscopy in diagnosis of sputum smear-negative pulmonary tuberculosis: a systemic review and meta-analysis.

BMC Pulm Med 2020 May 25;20(1):146. Epub 2020 May 25.

Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, 361001, China.

Background: Pulmonary tuberculosis is one of the most common infectious diseases worldwide. Patients with suspected pulmonary tuberculosis with negative smear are recommended to undergo further tests including sputum induction and bronchoscopy. Our study is aimed to compare sputum induction and bronchoscopic specimens in the diagnosis of sputum smear-negative pulmonary tuberculosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01192-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249394PMC

Correction to: Assessment of stigma in patients with cystic fibrosis.

BMC Pulm Med 2020 05 20;20(1):145. Epub 2020 May 20.

The Ottawa Hospital, 501 Smyth Road, Ottawa, Ontario, K1H 8 M5, Canada.

An amendment to this paper has been published and can be accessed via the original article. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-1176-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238593PMC

Prognosis of patients with acute exacerbation of combined pulmonary fibrosis and emphysema: a retrospective single-centre study.

BMC Pulm Med 2020 May 20;20(1):144. Epub 2020 May 20.

First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1, Asahi Matsumoto, Nagano Prefecture, 390-8621, Japan.

Background: Previous analyses of combined pulmonary fibrosis and emphysema (CPFE) cohorts have provided conflicting data on the survival of patients with CPFE. Therefore, the aim of this study was to investigate the clinical prognosis of acute exacerbations (AE) of CPFE.

Methods: We retrospectively reviewed the medical records of patients who had been treated at the Shinshu University Hospital (Matsumoto, Japan) between 2003 and 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01185-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238596PMC

Supervised pulmonary hypertension exercise rehabilitation (SPHERe): study protocol for a multi-centre randomised controlled trial.

BMC Pulm Med 2020 May 19;20(1):143. Epub 2020 May 19.

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.

Background: Supervised cardio-pulmonary rehabilitation may be safe and beneficial for people with pulmonary hypertension (PH) in groups 1 (pulmonary arterial hypertension) and 4 (chronic thromboembolic disease), particularly as a hospital in-patient. It has not been tested in the most common PH groups; 2 (left heart disease), 3 (lung disease), or 5 (other disorders). Further it has not been evaluated in the UK National Health Service (NHS) out-patient setting, or with long-term follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01182-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236437PMC

Multivariate joint modeling to identify markers of growth and lung function decline that predict cystic fibrosis pulmonary exacerbation onset.

BMC Pulm Med 2020 May 19;20(1):142. Epub 2020 May 19.

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Attenuated decreases in lung function can signal the onset of acute respiratory events known as pulmonary exacerbations (PEs) in children and adolescents with cystic fibrosis (CF). Univariate joint modeling facilitates dynamic risk prediction of PE onset and accounts for measurement error of the lung function marker. However, CF is a multi-system disease and the extent to which simultaneously modeling growth and nutrition markers improves PE predictive accuracy is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-1177-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236487PMC

Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.

BMC Pulm Med 2020 May 15;20(1):141. Epub 2020 May 15.

Medical Genetics Division, Department of Pediatrics, King Abdullah specialized Children's Hospital, King Abdulaziz Medical City, P. O Box 22490, Riyadh, 11426, Saudi Arabia.

Background: Primary Ciliary Dyskinesia (PCD) is also known as immotile-cilia syndrome, an autosomal recessive disorder of ciliary function, leading to mucus retention in the respiratory system in childhood. Our knowledge in the pathophysiological aspect of this devastating disorder is increasing with the advancement of genetic and molecular testing.

Case Presentation: Here in, we report two siblings with a classical clinical and radiological presentation of PCD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-1175-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229615PMC
May 2020
2.489 Impact Factor

Values of different specimen preparation methods for the diagnosis of lung cancer by endobronchial ultrasound guided transbronchial needle aspiration.

BMC Pulm Med 2020 May 15;20(1):140. Epub 2020 May 15.

Department of Respiratory Medicine, Tai Zhou Hospital of Zhejiang Province, LinHai, Zhejiang, P. R. China.

Background: Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has been become an important procedure for the diagnosis and staging of lung cancer. Our research identified the effects of different pathological preparation on the diagnosis of lung cancer for specimens obtained by biopsy.

Methods: Patients were clinically considered if lung cancer was accompanied by mediastinal or hilar lymph node enlargement between March 2014 and November 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-020-01183-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229603PMC