1,499 results match your criteria BMC Pulmonary Medicine[Journal]


Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis.

BMC Pulm Med 2019 Apr 18;19(1):81. Epub 2019 Apr 18.

Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: In many clinical disorders, there is a relationship between the ratio of the diameter of the main pulmonary artery (mPA) to that of the aorta (Ao) on chest computed tomography (CT). The aim of this study was to determine if the mPA/Ao ratio at diagnosis is associated with the clinical characteristics and outcomes in patients with idiopathic pulmonary fibrosis (IPF).

Methods: We retrospectively reviewed the diameters of the pulmonary artery and aorta on chest CT, clinical characteristics, and results of other examinations in 303 patients at the time of initial diagnosis of IPF at our tertiary care center between 2011 and 2015. Read More

View Article

Download full-text PDF

Source
https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
Publisher Site
http://dx.doi.org/10.1186/s12890-019-0843-5DOI Listing
April 2019
1 Read

The multiple systemic artery to pulmonary artery fistulas resulting in severe irreversible pulmonary arterial hypertension in patient with previous history of pneumothorax.

BMC Pulm Med 2019 Apr 16;19(1):80. Epub 2019 Apr 16.

2nd Department of Cardiology, School of Medicine with Dentistry Division in Zabrze, Medical University of Silesia, 10 Curie-Sklodowska str, 41-808, Zabrze, Poland.

Background: Systemic artery to pulmonary artery fistulas (SA-PAFs), are extremely rare in people without congenital heart disease. In this group of patients pulmonary arterial hypertension was reported in the single case. Then, we describe a case of multiple SA-PAFs, which were the cause of severe nonreversible arterial pulmonary hypertension in a patient who had a right-sided pneumothorax 35 years earlier. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0832-8DOI Listing
April 2019
1 Read

Hospital-acquired influenza in an Australian tertiary Centre 2017: a surveillance based study.

BMC Pulm Med 2019 Apr 16;19(1):79. Epub 2019 Apr 16.

Department of Infectious Diseases, Canberra Hospital and Health Services, Canberra, Australian Capital Territory, Australia.

Background: In 2017, Australia experienced its highest levels of influenza virus activity since the 2009 pandemic. This allowed detailed comparison of the characteristics of patients with community and hospital-acquired influenza, and infection control factors that contributed to influenza spread.

Methods: A surveillance based study was conducted on hospitalised patients with laboratory-confirmed influenza at the Canberra Hospital during April-October 2017. Read More

View Article

Download full-text PDF

Source
https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
Publisher Site
http://dx.doi.org/10.1186/s12890-019-0842-6DOI Listing
April 2019
2 Reads

Supporting medication adherence for adults with cystic fibrosis: a randomised feasibility study.

BMC Pulm Med 2019 Apr 11;19(1):77. Epub 2019 Apr 11.

Sheffield Adult Cystic Fibrosis Unit Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK.

Background: Preventative medication reduces hospitalisations in people with cystic fibrosis (PWCF) but adherence is poor. We assessed the feasibility of a randomised controlled trial of a complex intervention, which combines display of real time adherence data and behaviour change techniques.

Methods: Design: Pilot, open-label, parallel-group RCT with concurrent semi-structured interviews. Read More

View Article

Download full-text PDF

Source
https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
Publisher Site
http://dx.doi.org/10.1186/s12890-019-0834-6DOI Listing
April 2019
2 Reads

Negative impact of anorexia and weight loss during prior pirfenidone administration on subsequent nintedanib treatment in patients with idiopathic pulmonary fibrosis.

BMC Pulm Med 2019 Apr 11;19(1):78. Epub 2019 Apr 11.

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Tomioka-Higashi 6-16-1, Kanazawa-ku, Yokohama, 236-0051, Japan.

Background: Current clinical practice guidelines for idiopathic pulmonary fibrosis (IPF) conditionally recommend use of pirfenidone and nintedanib. However, an optimal treatment sequence has not been established, and the data of treatment sequence from pirfenidone to nintedanib are limited. This study aimed to evaluate safety, tolerability and efficacy of nintedanib switched from pirfenidone in patients with IPF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0841-7DOI Listing
April 2019
1 Read

Use of ivacaftor in late diagnosed cystic fibrosis monozygotic twins heterozygous for F508del and R117H-7T - a case report.

BMC Pulm Med 2019 Apr 11;19(1):76. Epub 2019 Apr 11.

Department of Pulmonary Medicine, University Hospital Essen - Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Tueschener Weg 40, 45329, Essen, Germany.

Background: CFTR modulator therapy with ivacaftor is a treatment option for Cystic Fibrosis (CF) patients with at least one copy of a R117H-7T mutation in the CFTR gene. Desirable effects of this therapy are improvement of lung function, decrease in exacerbation rate, normalization or reduction of sweat chloride and weight gain. Monogenetic CF-twins carry identical genetic information, so therapy response and side effects are expected to be nearly identical under this specific therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0840-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458608PMC
April 2019
1 Read

Study protocol: exploring the efficacy of cyclophosphamide added to corticosteroids for treating acute exacerbation of idiopathic pulmonary fibrosis; a randomized double-blind, placebo-controlled, multi-center phase III trial (EXAFIP).

BMC Pulm Med 2019 Apr 11;19(1):75. Epub 2019 Apr 11.

Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Avicenne, Service de pneumologie, Site constitutif du centre de référence des maladies pulmonaires rares OrphaLung, EA2363, Université Paris, 13, Bobigny, France.

Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, with a median survival of 2-3 years and variable natural history, characterized by gradual and progressive deterioration. Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe complication, associated with poor survival and a mortality > 50%. To date, no treatment has proven effective in AE-IPF, with cyclophosphamide (CYC) the only therapy suggested to be effective on survival, primarily based on retrospective series. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0830-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458697PMC
April 2019
1 Read

Comparison of bench test results measuring the accuracy of peak flow meters.

BMC Pulm Med 2019 Apr 8;19(1):74. Epub 2019 Apr 8.

St Mary's Hospital, London, UK.

Background: The study evaluates and compares the accuracy of nine peak flow meters ("PFMs") and spirometers that are currently available in Europe and have Conformité Européene ("CE") marking. The CE marking is a manufacturer's declaration that their product complies with European health regulations and it is a requirement for marketing medical devices in Europe.

Methods: The nine devices were selected as they all had received or were in the process of receiving CE approval in Europe and were readily obtainable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0837-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454778PMC

The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study.

BMC Pulm Med 2019 Apr 4;19(1):73. Epub 2019 Apr 4.

Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata-shi, Niigata, 951-8510, Japan.

Background: The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known. The objective of this study was to investigate the association between the extent of emphysema and long-term outcomes, as well as mortality and postoperative complications, in early-stage lung cancer patients after pulmonary resection.

Methods: The clinical records of 566 consecutive lung cancer patients who underwent pulmonary resection in our department were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0839-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449985PMC
April 2019
1 Read

Combination of clinical symptoms and blood biomarkers can improve discrimination between bacterial or viral community-acquired pneumonia in children.

BMC Pulm Med 2019 Apr 2;19(1):71. Epub 2019 Apr 2.

Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia.

Background: Differentiating bacterial from viral pneumonia is important for guiding targeted management and judicious use of antibiotics. We assessed if clinical characteristics and blood inflammatory biomarkers could be used to distinguish bacterial from viral pneumonia.

Methods: Western Australian children (≤17 years) hospitalized with radiologically-confirmed community-acquired pneumonia were recruited and clinical symptoms and management data were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0835-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444754PMC
April 2019
1 Read

Protective effect of bevacizumab on chemotherapy-related acute exacerbation of interstitial lung disease in patients with advanced non-squamous non-small cell lung cancer.

BMC Pulm Med 2019 Apr 2;19(1):72. Epub 2019 Apr 2.

Department of Respiratory Medicine, Kumamoto University Hospital, Faculty of Life Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Background: Acute exacerbation of interstitial lung disease (AE-ILD) is the most serious complication in lung cancer patients with pre-existing ILD receiving chemotherapy. The role of vascular endothelial growth factor (VEGF) in pathogenesis of AE-ILD is conflicting. The influence of bevacizumab (Bev), a monoclonal antibody against VEGF, on lung cancer patients with pre-existing ILD remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0838-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446385PMC
April 2019
1 Read

Reduced transient receptor potential vanilloid 2 expression in alveolar macrophages causes COPD in mice through impaired phagocytic activity.

BMC Pulm Med 2019 Mar 26;19(1):70. Epub 2019 Mar 26.

Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: Defective phagocytosis in alveolar macrophages is associated with chronic obstructive pulmonary disease (COPD). Transient receptor potential cation channel subfamily V member 2 (TRPV2), a type of nonselective cation channel pertinent to diverse physiological functions, regulates macrophage phagocytosis. However, the role of TRPV2 in COPD remains poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0821-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434859PMC
March 2019
1 Read

Correction to: Are there differences among operators in false-negative rates of endosonography with needle aspiration for mediastinal nodal staging of non-small cell lung cancer?

BMC Pulm Med 2019 03 25;19(1):69. Epub 2019 Mar 25.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-ro 81, Gangnam-gu, Seoul, 06351, Republic of Korea.

Following publication of the original. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0805-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434843PMC
March 2019
1 Read

Risk of acute exacerbations in chronic obstructive pulmonary disease associated with biomass smoke compared with tobacco smoke.

BMC Pulm Med 2019 Mar 22;19(1):68. Epub 2019 Mar 22.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea.

Background: Risk of exacerbations in chronic obstructive pulmonary disease (COPD) associated with biomass smoke has not been well addressed, although biomass smoke is similar in composition to tobacco smoke.

Methods: To investigate whether the risk of exacerbations in COPD associated with biomass smoke differs from that in COPD associated with tobacco smoke, we recruited patients with COPD from two Korean multicenter prospective cohorts. In a multiple linear regression model, the standardized regression coefficient (β) of biomass smoke exposure ≥25 years was most similar to that (β) of tobacco smoke exposure ≥10 pack-years (β = - 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0833-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429752PMC
March 2019
1 Read

The patient experience of pulmonary hypertension: a large cross-sectional study of UK patients.

BMC Pulm Med 2019 Mar 21;19(1):67. Epub 2019 Mar 21.

Pulmonary Hypertension CNS, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK.

Background: Pulmonary Hypertension Association UK (PHA-UK) is the only charity in the UK especially for people affected by pulmonary hypertension (PH). To better understand the impact of PH on patients and carers beyond clinical symptoms, the PHA-UK carried out a cross-sectional survey on the effect of PH on daily living, along with a follow-up survey assessing the financial impact of PH.

Methods: This is a descriptive cross-sectional survey of adult patients with PH in the UK. Read More

View Article

Download full-text PDF

Source
https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
Publisher Site
http://dx.doi.org/10.1186/s12890-019-0827-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429756PMC
March 2019
4 Reads

Elevated serum OX40L is a biomarker for identifying corticosteroid resistance in pediatric asthmatic patients.

Authors:
Su-Li Ma Lei Zhang

BMC Pulm Med 2019 Mar 19;19(1):66. Epub 2019 Mar 19.

Department of Pediatrics, Pudong New District People's Hospital, Shanghai University of Medicine & Health Sciences, No.490 South Huanchuan Road, Pudong New District, Shanghai, 201200, China.

Background: Corticosteroids are widely used to control asthma symptoms, but steroid resistance (SR) is a common adverse reaction. Therefore, it is important to accurately predict the corticosteroid response of asthmatic patients. This study aims to evaluate the serum OX40 ligand (OX40L) in pediatric asthmatic patients, and to investigated its correlations with clinical characteristics and corticosteroid response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0819-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423878PMC
March 2019
2 Reads

Case report: new development of fibrosing interstitial lung disease triggered by HIV-related pneumocystis pneumonia.

BMC Pulm Med 2019 Mar 18;19(1):65. Epub 2019 Mar 18.

AIDS Clinical Center, National Center of Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: Fibrosing interstitial lung disease is the poor prognostic non-infectious lung disease by unknown etiology. Here, we present one case developing interstitial pneumonia with fibrosis after treatment of pneumocystis pneumonia (PCP) in newly diagnosed HIV-1 infected case.

Case Presentation: A previously healthy 63-year old male was referred to our institute because of protracted dyspnea on effort in 2 weeks after pneumocystis pneumonia treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0831-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423812PMC
March 2019
3 Reads

Determinants of frailty in primary care patients with COPD: the Greek UNLOCK study.

BMC Pulm Med 2019 Mar 15;19(1):63. Epub 2019 Mar 15.

Department of Social Medicine, Faculty of Medicine, University of Crete, Voutes Campus, GR-71003, Heraklion, Crete, Greece.

Background: Frailty is a state of increased vulnerability that has a significant risk of unfavorable outcomes such as increased dependency and/or death, but little is known about frailty in people with chronic obstructive pulmonary disease (COPD).

Method: We aimed to determine the prevalence of frailty in COPD patients and to identify the associated risk factors. Two hundred fifty-seven COPD patients enrolled from primary care in Greece between 2015 and 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0824-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419845PMC
March 2019
2 Reads

Korean childhood asthma study (KAS): a prospective, observational cohort of Korean asthmatic children.

BMC Pulm Med 2019 Mar 15;19(1):64. Epub 2019 Mar 15.

Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Osong, South Korea.

Background: Asthma is a syndrome composed of heterogeneous disease entities. Although it is agreed that proper asthma endo-typing and appropriate type-specific interventions are crucial in the management of asthma, little data are available regarding pediatric asthma.

Methods: We designed a cluster-based, prospective, observational cohort study of asthmatic children in Korea (Korean childhood Asthma Study [KAS]). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0829-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420748PMC
March 2019
3 Reads

Tuberculosis and other bacterial co-infection in Cambodia: a single center retrospective cross-sectional study.

BMC Pulm Med 2019 Mar 11;19(1):60. Epub 2019 Mar 11.

International Respiratory and Severe Illness Center, University of Washington, Seattle, WA, USA.

Background: Cambodia, a lower middle-income country of about 16 million individuals in southeast Asia, endures a high burden of both tuberculosis and other lower respiratory infections. Differentiating tuberculosis from other causes of respiratory infection has important clinical implications yet may be challenging to accomplish in the absence of diagnostic microbiology facilities. Furthermore, co-infection of tuberculosis with other bacterial lower respiratory infections may occur. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0828-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417204PMC
March 2019
1 Read

Combined-modality therapy for pulmonary alveolar proteinosis in a remote setting: a case report.

BMC Pulm Med 2019 Mar 12;19(1):61. Epub 2019 Mar 12.

Department of Medicine, Tripler Army Medical Center, 1 Jarrett White Rd, Tripler AMC, Hawaii, 96859, USA.

Background: Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of phospholipoproteinaceous material in the alveoli. The presentation is nonspecific but typically includes dyspnea; the spectrum of disease includes rapidly progressive hypoxic respiratory failure. Whole lung lavage (WLL) is the treatment of choice in symptomatic PAP, but transient worsening of oxygenation sometimes requires salvage modalities of support such as extracorporeal membrane oxygenation (ECMO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0822-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417025PMC
March 2019
1 Read

Reduced forced vital capacity is independently associated with ethnicity, metabolic factors and respiratory symptoms in a Caribbean population: a cross-sectional study.

BMC Pulm Med 2019 Mar 14;19(1):62. Epub 2019 Mar 14.

Faculty of Medical Sciences, Department of Clinical Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Background: Relationships between low forced vital capacity (FVC), and morbidity have previously been studied but there are no data available for the Caribbean population. This study assessed the association of low FVC with risk factors, health variables and socioeconomic status in a community-based study of the Trinidad and Tobago population.

Methods: A cross-sectional survey was conducted using the Burden of Obstructive Lung Disease (BOLD) study protocol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0823-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416949PMC

Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols.

BMC Pulm Med 2019 Mar 7;19(1):59. Epub 2019 Mar 7.

Division of Pulmonary, Allergy, and Critical Care Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.

Background: Lung cancer is the leading cause of cancer-related death due in large part to our inability to diagnose it at an early and potentially curable stage. Screening for lung cancer via low dose computed tomographic (LDCT) imaging has been demonstrated to improve mortality but also results in a high rate of false positive tests. The identification and application of non-invasive molecular biomarkers that improve the performance of CT imaging for the detection of lung cancer in high risk individuals would aid in clinical decision-making, eliminate the need for unnecessary LDCT follow-up, and further refine the screening criteria for an already large high-risk population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0825-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407252PMC
March 2019
2 Reads

Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population.

BMC Pulm Med 2019 Mar 7;19(1):58. Epub 2019 Mar 7.

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700, RB, Groningen, The Netherlands.

Background: Airflow obstruction is a hallmark of chronic obstructive pulmonary disease (COPD), and is defined as either the ratio between forced expiratory volume in one second and forced vital capacity (FEV/FVC) < 70% or < lower limit of normal (LLN). This study aimed to assess the overlap between genome-wide association studies (GWAS) on airflow obstruction using these two definitions in the same population stratified by smoking.

Methods: GWASes were performed in the LifeLines Cohort Study for both airflow obstruction definitions in never-smokers (NS = 5071) and ever-smokers (ES = 4855). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0811-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407273PMC
March 2019
1 Read
2.489 Impact Factor

Transbronchial biopsy from the upper pulmonary lobes is associated with increased risk of pneumothorax - a retrospective study.

BMC Pulm Med 2019 03 1;19(1):56. Epub 2019 Mar 1.

Department of Respiratory Diseases, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavska 20, 62500, Brno, Czech Republic.

Background: Pneumothorax (PTX) is one of the most common complications of transbronchial biopsy (TBB). Previous research suggests that upper pulmonary lobe TBB may be associated with increased risk of PTX development. The aim of this study was to compare the risk of PTX after TBB performed from different pulmonary lobes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0820-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397442PMC

Effects of a long-term home-based exercise training programme using minimal equipment vs. usual care in COPD patients: a study protocol for two multicentre randomised controlled trials (HOMEX-1 and HOMEX-2 trials).

BMC Pulm Med 2019 Mar 1;19(1):57. Epub 2019 Mar 1.

Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Hirschengraben 84, 8001, Zurich, Switzerland.

Background: Exercise training is an important component of pulmonary rehabilitation (PR) programmes in chronic obstructive pulmonary disease (COPD), but the great majority of COPD patients who would benefit from PR never follow such programmes or fail to maintain exercise training after PR completion. Against this background, we developed an exercise training programme that requires minimal equipment and can be implemented long-term in the patient's home-setting. The aims of the HOMEX-1 and HOMEX-2 trials are to assess the effectiveness of this home-based exercise training programme in two groups of COPD patients over the course of one year: patients who have completed PR (HOMEX-1 trial) and patients who did not enrol in existing PR programmes within the last two years (HOMEX-2 trial). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0817-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397487PMC
March 2019
2 Reads

The economic burden of bronchiectasis - known and unknown: a systematic review.

BMC Pulm Med 2019 Feb 28;19(1):54. Epub 2019 Feb 28.

Scottish Centre for Respiratory Research, University of Dundee, Dundee, UK.

Background: The increasing prevalence and recognition of bronchiectasis in clinical practice necessitates a better understanding of the economic disease burden to improve the management and achieve better clinical and economic outcomes. This study aimed to assess the economic burden of bronchiectasis based on a review of published literature.

Methods: A systematic literature review was conducted using MEDLINE, Embase, EconLit and Cochrane databases to identify publications (1 January 2001 to 31 December 2016) on the economic burden of bronchiectasis in adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0818-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393984PMC
February 2019
1 Read

Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer.

BMC Pulm Med 2019 Feb 28;19(1):55. Epub 2019 Feb 28.

Molecular Oncology and Embryology Laboratory, Human Anatomy Unit, School of Medicine, University of Barcelona, IDIBAPS, Casanova 143, 08036, Barcelona, Spain.

Background: HOTTIP, a long non-coding RNA located in the HOXA cluster, plays a role in the patterning of tissues with mesodermal components, including the lung. Overexpression of HOXA genes, including HOTTIP, has been associated with a more aggressive phenotype in several cancers. However, the prognostic impact of HOTTIP has not yet been explored in non-small-cell lung cancer (NSCLC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0816-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393998PMC
February 2019
2 Reads
2.489 Impact Factor

The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis.

BMC Pulm Med 2019 Feb 26;19(1):53. Epub 2019 Feb 26.

Department of Respiratory and Critical Care, West China School of Medicine and West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, China.

Background: Studies investigating the role of hyperoxia in critically ill patients have reported conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients admitted to the intensive care unit (ICU).

Methods: Electronic databases were searched for all the studies exploring the role of hyperoxia in adult patients admitted to ICU. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0810-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390560PMC
February 2019
1 Read

REgistry-based randomized controlled trial of treatment and Duration and mortality in long-term OXygen therapy (REDOX) study protocol.

BMC Pulm Med 2019 Feb 26;19(1):50. Epub 2019 Feb 26.

Department of Clinical Sciences, Division of Respiratory Medicine & Allergology, Lund University, Lund, Sweden.

Objective: Long-term oxygen therapy (LTOT) during 15 h/day or more prolongs survival in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemia. No randomized controlled trial has evaluated the net effects (benefits or harms) from LTOT 24 h/day compared with 15 h/day or the effect in conditions other than COPD. We describe a multicenter, national, phase IV, non-superiority, registry-based, randomized controlled trial (R-RCT) of LTOT prescribed 24 h/day compared with 15 h/day. Read More

View Article

Download full-text PDF

Source
https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
Publisher Site
http://dx.doi.org/10.1186/s12890-019-0809-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390558PMC
February 2019
21 Reads

A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults.

BMC Pulm Med 2019 Feb 26;19(1):52. Epub 2019 Feb 26.

Department of Psychology, University of Oslo, Oslo, Norway.

Background: A small number of studies have shown that the use of cannabis increases the risk of bronchial asthma. There is, however, a paucity of longitudinal studies which are able to control for known risk factors of bronchial asthma.

Methods: Survey data from a population-based longitudinal study encompassing 2602 young adults followed for 13 years were coupled with individual prescription data on asthma medication (β-adrenergic receptor agonists and glucocorticoids for inhalation) from the Norwegian national prescription database, which covers the entire Norwegian population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0814-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390535PMC
February 2019
8 Reads

Utility of bronchoalveolar lavage in the management of immunocompromised patients presenting with lung infiltrates.

BMC Pulm Med 2019 Feb 26;19(1):51. Epub 2019 Feb 26.

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Academia Building Level 3, 20 College Road, S169856, Singapore, Singapore.

Background: Bronchoalveolar lavage (BAL) is utilized for diagnosing lung infiltrates in immunocompromised. There is heterogeneity in the data and reported diagnostic yields range from 26 to 69%. Therefore, selection criteria for BAL to maximize yield and minimize complications are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0801-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390608PMC
February 2019

Hypoxia due to intrapulmonary vascular dilatation in a toddler with a congenital portacaval shunt: case report.

BMC Pulm Med 2019 Feb 22;19(1):49. Epub 2019 Feb 22.

College of Medicine and Health Sciences - UAE University, Alain City, United Arab Emirates.

Background: The term hepatopulmonary syndrome typically applies to cyanosis that results from "intrapulmonary vascular dilatation" due to advanced liver disease. Similar findings may result from a congenital portosystemic shunt without liver disease. An adverse consequence of such shunts is intrapulmonary vascular dilatation, which affects the microvascular gas exchange units for oxygen. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0788-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387555PMC
February 2019
2 Reads

Prognostic significance of crazy paving ground grass opacities in non-HIV Pneumocystis jirovecii pneumonia: an observational cohort study.

BMC Pulm Med 2019 Feb 21;19(1):47. Epub 2019 Feb 21.

Department of Respiratory Medicine, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-0052, Japan.

Background: In patients with non-HIV Pneumocystis jirovecii pneumonia (PjP), computed tomography imaging reveals ground grass opacities (GGO). Previous reports show that some patients with non-HIV PjP exhibit GGO with crazy paving. However, there have been no studies on the association between crazy paving GGO and non-HIV PjP clinical outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0813-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385404PMC
February 2019
2 Reads

Progressive disseminated histoplasmosis with concomitant disseminated nontuberculous mycobacterial infection in a patient with AIDS from a nonendemic region (California).

BMC Pulm Med 2019 Feb 21;19(1):46. Epub 2019 Feb 21.

Department of Infectious Disease, Arrowhead Regional Medical Center, Colton, USA.

Background: Opportunistic infections, while well studied in the AIDS population, continue to have variable and surprising presentations. Here, we present a case of disseminated histoplasmosis with disseminated nontuberculous mycobacterial infection in a 50 year old man with long standing AIDS living in a non-endemic area.

Case Presentation: Patient presented with a constellation of symptoms, and imaging of the chest showed a pulmonary mass with cavitation, multiple nodules, and ground glass opacities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0808-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383272PMC
February 2019

The impact of early diagnosis on the prognosis of extranodal NK/T-cell lymphoma with massive lung involvement: a case report.

BMC Pulm Med 2019 Feb 21;19(1):48. Epub 2019 Feb 21.

Department of Hematology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan.

Background: Pulmonary non-Hodgkin lymphoma (NHL) is rare. The most frequent subtype of pulmonary NHL is low-grade B-cell lymphoma, such as lymphoma of mucosa-associated lymphoma tissue. Extranodal natural killer cell/T-cell lymphoma, nasal type (ENKL) is characterized by predominant extranodal involvement and association with Epstein-Barr virus (EBV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0815-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385406PMC
February 2019
2 Reads

A spatial analysis of geographic variation and factors associated with hospitalization for bacterial pneumonia in Korea.

BMC Pulm Med 2019 Feb 20;19(1):45. Epub 2019 Feb 20.

Department of Health Policy and Management, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, Republic of Korea.

Background: The incidence of pneumonia in Korea started to increase in the 1990's after a period of decrease and stabilization, and the mortality and hospitalization rates for pneumonia in Korea are alarmingly high. This study was performed to examine geographic variation and factors associated with hospitalization for bacterial pneumonia in Korea.

Methods: Data were acquired from the inpatient claims of the 2015 period of the National Health Insurance Service. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0798-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383222PMC
February 2019
2 Reads

Impact of leaks and ventilation parameters on the efficacy of humidifiers during home ventilation for tracheostomized patients: a bench study.

BMC Pulm Med 2019 Feb 18;19(1):43. Epub 2019 Feb 18.

Service de Pneumologie et Réanimation Médicale (Département "R3S")AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, 47-83 boulevard de l'hôpital, F-75013, Paris, France.

Background: During invasive ventilation, the upper airway is bypassed and no longer participates in humidification of inspired gases, which is essential to avoid harmful consequences such as endotracheal tube occlusion. In the case of increased air flow, especially in the presence of leaks (intentional or unintentional), the humidification provided by humidifiers may become ineffective. The objective of this bench study was to evaluate the quality of humidification provided by heated humidifiers under various home ventilation conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0812-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379988PMC
February 2019
1 Read

Postpneumonectomy-like syndrome due to bronchial carcinoid: a unique case report.

BMC Pulm Med 2019 Feb 18;19(1):44. Epub 2019 Feb 18.

1st Respiratory Medicine Department, University of Athens, "Sotiria" Hospital, 152 Mesogeion Ave, 115 27, Athens, Greece.

Background: Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contralateral hemithorax, mimicking the mediastinal shift observed in postpneumonectomy syndrome after pneumonectomy. We report a unique case of postpneumonectomy-like syndrome caused by an atypical bronchial carcinoid completely occluding the left main bronchus.

Case Presentation: A 25-year-old woman presented with symptoms of chronic exertional dyspnea and productive cough. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-018-0767-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380005PMC
February 2019
1 Read

Atypical bronchial carcinoid with postobstructive mycobacterial infection: case report and review of literature.

BMC Pulm Med 2019 Feb 15;19(1):41. Epub 2019 Feb 15.

Department of Pulmonary Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low among clinicians. The synchronous presentation of lung cancer and mycobacterial infection is well known but the combination of pulmonary carcinoid and mycobacterial infection is rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0806-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376781PMC
February 2019
1 Read

Aerosol drug delivery to the lungs during nasal high flow therapy: an in vitro study.

BMC Pulm Med 2019 Feb 15;19(1):42. Epub 2019 Feb 15.

Advanced Drug Delivery Group, School of Pharmacy, The University of Sydney Faculty of Medicine and Health, Sydney, NSW, 2006, Australia.

Background: Aerosol delivery through a nasal high flow (NHF) system is attractive for clinicians as it allows for simultaneous administration of oxygen and inhalable drugs. However, delivering a fine particle fraction (FPF, particle wt. fraction < 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0807-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376697PMC
February 2019
1 Read

Asthma and atopy prevalence are not reduced among former tuberculosis patients compared with controls in Lima, Peru.

BMC Pulm Med 2019 Feb 13;19(1):40. Epub 2019 Feb 13.

The University of Sydney, St. Vincent's Hospital Sydney, Heart Lung Clinic, Xavier Building. 390, Victoria Street, 2010, Australia.

Background: Although there are theoretical reasons for believing that asthma and atopy may be negatively correlated with tuberculosis, epidemiological studies have had conflicting findings.

Objective: To determine if people with confirmed tuberculosis were less likely to be atopic and less likely to have atopic disease including asthma compared to those with no previous tuberculosis.

Methods: Patients in Lima, Peru with a prior history of tuberculosis were identified from clinic records in this cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0804-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373156PMC
February 2019
1 Read

NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis.

BMC Pulm Med 2019 Feb 13;19(1):39. Epub 2019 Feb 13.

Department of Pulmonology, Hospital de São João and Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Diffuse lung diseases (DLD) are characterized by different immunophenotypes in the bronchoalveolar lavage fluid (BALF). We aimed to evaluate the diagnostic value of BALF NK and NKT cell counts of patients with DLD and lymphocytic alveolitis.

Methods: We assessed 202 patients with DLD, who underwent BALF immunophenotyping. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0802-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373142PMC
February 2019
2 Reads

Age distribution and seasonality in acute eosinophilic pneumonia: analysis using a national inpatient database.

BMC Pulm Med 2019 Feb 12;19(1):38. Epub 2019 Feb 12.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.

Background: Acute eosinophilic pneumonia (AEP) is a rare inflammatory lung disease. Previous studies have shown that most patients with AEP are aged 20 to 40 years, whereas several case studies have included older patients with AEP. These studies also suggested that AEP is more prevalent in summer, but they were limited due to their small sample sizes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0800-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371551PMC
February 2019
2 Reads

Bronchoscopy to assess patients with hemoptysis: which is the optimal timing?

BMC Pulm Med 2019 Feb 11;19(1):36. Epub 2019 Feb 11.

Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical, Experimental Sciences, University of Sassari, Sassari, Italy.

Background: Bronchoscopy plays a key role to diagnose the etiology, to localize the site, and to identify the sources of the bleeding in patients with hemoptysis, but the ideal timing of an endoscopic examination is still unclear.

Methods: We performed a secondary analysis of an observational and multicenter study, aimed at evaluating the epidemiology of hemoptysis in Italy and the diagnostic yield of the most frequently prescribed examinations. The aim of the study was to evaluate whether an early bronchoscopy (i. Read More

View Article

Download full-text PDF

Source
https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
Publisher Site
http://dx.doi.org/10.1186/s12890-019-0795-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371580PMC
February 2019
11 Reads

Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression.

BMC Pulm Med 2019 Feb 11;19(1):35. Epub 2019 Feb 11.

Department of Emergency, the First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunan, People's Republic of China.

Background: Reactive oxygen species (ROS) levels largely determine pulmonary fibrosis. Antioxidants have been found to ameliorate lung fibrosis after long-term paraquat (PQ) exposure. The effects of antioxidants, however, on the signalling pathways involved in PQ-induced lung fibrosis have not yet been investigated sufficiently. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0799-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371511PMC
February 2019
2 Reads

Prognostic values of the Berlin definition criteria, blood lactate level, and fibroproliferative changes on high-resolution computed tomography in ARDS patients.

BMC Pulm Med 2019 Feb 11;19(1):37. Epub 2019 Feb 11.

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Background: In the Berlin definition, acute respiratory distress syndrome (ARDS) is stratified into three stages according to oxygenation severity at the onset. The relevance between ARDS severity and prognosis varies among published reports and has not been verified, especially in Asian patients.

Methods: In this study, we examined the associations between the Berlin definition criteria and prognosis and clinical parameters, including high-resolution computed tomography (HRCT) scores of fibroproliferative changes of the lungs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0803-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371514PMC
February 2019
3 Reads

Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study.

BMC Pulm Med 2019 Feb 8;19(1):33. Epub 2019 Feb 8.

Department of Respiratory Medicine, Chengdu Third People's Hospital, NO.82 Qinglong Street, Qingyang District, Chengdu, 610031, Sichuan, China.

Background: Self-expandable metallic stents (SEMSs) have enabled a approving management of malignant airway stenosis. However, the long-term efficacy and safety of this treatment in patients with benign airway stricture are unclear. We conducted this study to retrospectively determine the efficacy and long-term outcomes in patients who have undergone SEMS placement for benign tracheobronchial stenosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0793-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368722PMC
February 2019

Pulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case report.

BMC Pulm Med 2019 Feb 8;19(1):34. Epub 2019 Feb 8.

Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Background: Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder defined by high serum immunoglobulin E titers that is associated with recurrent respiratory infections, formation of pneumoatoceles, recurrent skin abscesses, and characteristic dental and skeletal abnormalities.

Case Presentation: We report a case of a 56-year-old male with a history of HIES, cavitary mycetomas, and allergic bronchopulmonary aspergillosis who presented with recurrent massive hemoptysis. Bronchial artery angiography and bronchoscopy failed to identify active hemorrhage, and two embolizations of the bronchial artery did not resolve the bleeding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0797-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368789PMC
February 2019
2 Reads

Health-related quality of life varies in different respiratory disorders: a multi-case control population based study.

BMC Pulm Med 2019 Feb 7;19(1):32. Epub 2019 Feb 7.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, c/o Istituti Biologici II, Strada Le Grazie 8, 37134, Verona, Italy.

Background And Objective: Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB).

Methods: Controls (n = 328) and cases of NAR (n = 95), AR (n = 163), CB (n = 48), CA (n = 224), PA (n = 126) and COPD (n = 28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-019-0796-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367788PMC
February 2019
2 Reads