1,462 results match your criteria BMC Pulmonary Medicine[Journal]


Impact of leaks and ventilation parameters on the efficacy of humidifiers during home ventilation for tracheostomized patients: a bench study.

BMC Pulm Med 2019 Feb 18;19(1):43. Epub 2019 Feb 18.

Service de Pneumologie et Réanimation Médicale (Département "R3S")AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, 47-83 boulevard de l'hôpital, F-75013, Paris, France.

Background: During invasive ventilation, the upper airway is bypassed and no longer participates in humidification of inspired gases, which is essential to avoid harmful consequences such as endotracheal tube occlusion. In the case of increased air flow, especially in the presence of leaks (intentional or unintentional), the humidification provided by humidifiers may become ineffective. The objective of this bench study was to evaluate the quality of humidification provided by heated humidifiers under various home ventilation conditions. Read More

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http://dx.doi.org/10.1186/s12890-019-0812-zDOI Listing
February 2019

Postpneumonectomy-like syndrome due to bronchial carcinoid: a unique case report.

BMC Pulm Med 2019 Feb 18;19(1):44. Epub 2019 Feb 18.

1st Respiratory Medicine Department, University of Athens, "Sotiria" Hospital, 152 Mesogeion Ave, 115 27, Athens, Greece.

Background: Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contralateral hemithorax, mimicking the mediastinal shift observed in postpneumonectomy syndrome after pneumonectomy. We report a unique case of postpneumonectomy-like syndrome caused by an atypical bronchial carcinoid completely occluding the left main bronchus.

Case Presentation: A 25-year-old woman presented with symptoms of chronic exertional dyspnea and productive cough. Read More

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http://dx.doi.org/10.1186/s12890-018-0767-5DOI Listing
February 2019

Atypical bronchial carcinoid with postobstructive mycobacterial infection: case report and review of literature.

BMC Pulm Med 2019 Feb 15;19(1):41. Epub 2019 Feb 15.

Department of Pulmonary Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low among clinicians. The synchronous presentation of lung cancer and mycobacterial infection is well known but the combination of pulmonary carcinoid and mycobacterial infection is rare. Read More

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http://dx.doi.org/10.1186/s12890-019-0806-xDOI Listing
February 2019
1 Read

Aerosol drug delivery to the lungs during nasal high flow therapy: an in vitro study.

BMC Pulm Med 2019 Feb 15;19(1):42. Epub 2019 Feb 15.

Advanced Drug Delivery Group, School of Pharmacy, The University of Sydney Faculty of Medicine and Health, Sydney, NSW, 2006, Australia.

Background: Aerosol delivery through a nasal high flow (NHF) system is attractive for clinicians as it allows for simultaneous administration of oxygen and inhalable drugs. However, delivering a fine particle fraction (FPF, particle wt. fraction < 5. Read More

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http://dx.doi.org/10.1186/s12890-019-0807-9DOI Listing
February 2019
1 Read

Asthma and atopy prevalence are not reduced among former tuberculosis patients compared with controls in Lima, Peru.

BMC Pulm Med 2019 Feb 13;19(1):40. Epub 2019 Feb 13.

The University of Sydney, St. Vincent's Hospital Sydney, Heart Lung Clinic, Xavier Building. 390, Victoria Street, 2010, Australia.

Background: Although there are theoretical reasons for believing that asthma and atopy may be negatively correlated with tuberculosis, epidemiological studies have had conflicting findings.

Objective: To determine if people with confirmed tuberculosis were less likely to be atopic and less likely to have atopic disease including asthma compared to those with no previous tuberculosis.

Methods: Patients in Lima, Peru with a prior history of tuberculosis were identified from clinic records in this cohort study. Read More

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http://dx.doi.org/10.1186/s12890-019-0804-zDOI Listing
February 2019
1 Read

NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis.

BMC Pulm Med 2019 Feb 13;19(1):39. Epub 2019 Feb 13.

Department of Pulmonology, Hospital de São João and Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Diffuse lung diseases (DLD) are characterized by different immunophenotypes in the bronchoalveolar lavage fluid (BALF). We aimed to evaluate the diagnostic value of BALF NK and NKT cell counts of patients with DLD and lymphocytic alveolitis.

Methods: We assessed 202 patients with DLD, who underwent BALF immunophenotyping. Read More

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http://dx.doi.org/10.1186/s12890-019-0802-1DOI Listing
February 2019
2 Reads

Age distribution and seasonality in acute eosinophilic pneumonia: analysis using a national inpatient database.

BMC Pulm Med 2019 Feb 12;19(1):38. Epub 2019 Feb 12.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 1130033, Japan.

Background: Acute eosinophilic pneumonia (AEP) is a rare inflammatory lung disease. Previous studies have shown that most patients with AEP are aged 20 to 40 years, whereas several case studies have included older patients with AEP. These studies also suggested that AEP is more prevalent in summer, but they were limited due to their small sample sizes. Read More

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http://dx.doi.org/10.1186/s12890-019-0800-3DOI Listing
February 2019

Bronchoscopy to assess patients with hemoptysis: which is the optimal timing?

BMC Pulm Med 2019 Feb 11;19(1):36. Epub 2019 Feb 11.

Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical, Experimental Sciences, University of Sassari, Sassari, Italy.

Background: Bronchoscopy plays a key role to diagnose the etiology, to localize the site, and to identify the sources of the bleeding in patients with hemoptysis, but the ideal timing of an endoscopic examination is still unclear.

Methods: We performed a secondary analysis of an observational and multicenter study, aimed at evaluating the epidemiology of hemoptysis in Italy and the diagnostic yield of the most frequently prescribed examinations. The aim of the study was to evaluate whether an early bronchoscopy (i. Read More

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http://dx.doi.org/10.1186/s12890-019-0795-9DOI Listing
February 2019
4 Reads

Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression.

BMC Pulm Med 2019 Feb 11;19(1):35. Epub 2019 Feb 11.

Department of Emergency, the First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunan, People's Republic of China.

Background: Reactive oxygen species (ROS) levels largely determine pulmonary fibrosis. Antioxidants have been found to ameliorate lung fibrosis after long-term paraquat (PQ) exposure. The effects of antioxidants, however, on the signalling pathways involved in PQ-induced lung fibrosis have not yet been investigated sufficiently. Read More

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http://dx.doi.org/10.1186/s12890-019-0799-5DOI Listing
February 2019

Prognostic values of the Berlin definition criteria, blood lactate level, and fibroproliferative changes on high-resolution computed tomography in ARDS patients.

BMC Pulm Med 2019 Feb 11;19(1):37. Epub 2019 Feb 11.

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Background: In the Berlin definition, acute respiratory distress syndrome (ARDS) is stratified into three stages according to oxygenation severity at the onset. The relevance between ARDS severity and prognosis varies among published reports and has not been verified, especially in Asian patients.

Methods: In this study, we examined the associations between the Berlin definition criteria and prognosis and clinical parameters, including high-resolution computed tomography (HRCT) scores of fibroproliferative changes of the lungs. Read More

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http://dx.doi.org/10.1186/s12890-019-0803-0DOI Listing
February 2019

Long-term follow-up of self-expandable metallic stents in benign tracheobronchial stenosis: a retrospective study.

BMC Pulm Med 2019 Feb 8;19(1):33. Epub 2019 Feb 8.

Department of Respiratory Medicine, Chengdu Third People's Hospital, NO.82 Qinglong Street, Qingyang District, Chengdu, 610031, Sichuan, China.

Background: Self-expandable metallic stents (SEMSs) have enabled a approving management of malignant airway stenosis. However, the long-term efficacy and safety of this treatment in patients with benign airway stricture are unclear. We conducted this study to retrospectively determine the efficacy and long-term outcomes in patients who have undergone SEMS placement for benign tracheobronchial stenosis. Read More

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http://dx.doi.org/10.1186/s12890-019-0793-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368722PMC
February 2019

Pulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case report.

BMC Pulm Med 2019 Feb 8;19(1):34. Epub 2019 Feb 8.

Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Background: Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder defined by high serum immunoglobulin E titers that is associated with recurrent respiratory infections, formation of pneumoatoceles, recurrent skin abscesses, and characteristic dental and skeletal abnormalities.

Case Presentation: We report a case of a 56-year-old male with a history of HIES, cavitary mycetomas, and allergic bronchopulmonary aspergillosis who presented with recurrent massive hemoptysis. Bronchial artery angiography and bronchoscopy failed to identify active hemorrhage, and two embolizations of the bronchial artery did not resolve the bleeding. Read More

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http://dx.doi.org/10.1186/s12890-019-0797-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368789PMC
February 2019
1 Read

Health-related quality of life varies in different respiratory disorders: a multi-case control population based study.

BMC Pulm Med 2019 Feb 7;19(1):32. Epub 2019 Feb 7.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, c/o Istituti Biologici II, Strada Le Grazie 8, 37134, Verona, Italy.

Background And Objective: Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB).

Methods: Controls (n = 328) and cases of NAR (n = 95), AR (n = 163), CB (n = 48), CA (n = 224), PA (n = 126) and COPD (n = 28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. Read More

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http://dx.doi.org/10.1186/s12890-019-0796-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367788PMC
February 2019
1 Read

TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis.

BMC Pulm Med 2019 Feb 7;19(1):31. Epub 2019 Feb 7.

Experimental and Translational Respiratory Medicine Group, Level 2 East, Hunter Medical Research Institute, School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, NSW, 2308, Australia.

Background: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has previously been demonstrated to play a pro-inflammatory role in allergic airways disease and COPD through the upregulation of the E3 ubiquitin ligase MID1 and the subsequent deactivation of protein phosphatase 2A (PP2A).

Methods: Biopsies were taken from eight IPF patients presenting to the Second Affiliated Hospital of Jilin University, China between January 2013 and February 2014 with control samples obtained from resected lung cancers. Serum TRAIL, MID1 protein and PP2A activity in biopsies, and patients' lung function were measured. Read More

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http://dx.doi.org/10.1186/s12890-019-0786-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367767PMC
February 2019

Severe thoracic trauma caused left pneumonectomy complicated by right traumatic wet lung, reversed by extracorporeal membrane oxygenation support-a case report.

BMC Pulm Med 2019 Feb 6;19(1):30. Epub 2019 Feb 6.

Critical Care Medicine Department of The First People's Hospital of Foshan, Lingnan Avenue North 81, Shiwan, Chancheng, Foshan, 528000, China.

Background: Double lumen intubation and one-lung ventilation should be applied without delay in cases of traumatic main bronchial rupture. In most cases, when the patients' vital signs have been stabilized, the repair can be performed. However, when one-lung ventilation is complicated by traumatic wet lung, the mortality rate is likely to be much higher. Read More

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http://dx.doi.org/10.1186/s12890-019-0790-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366044PMC
February 2019
1 Read

CD147 increases mucus secretion induced by cigarette smoke in COPD.

BMC Pulm Med 2019 Feb 6;19(1):29. Epub 2019 Feb 6.

Department of Gerontology and Respirology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.

Background: CD147 is expressed in many tissues and is involved in many inflammatory diseases. Emerging evidence suggests that the overproduction of mucus is a malignant factor in chronic obstructive pulmonary disease (COPD), which results in severe airway obstruction and repeated airway infections. However, it is still unclear whether CD147 is involved in mucus production in COPD. Read More

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http://dx.doi.org/10.1186/s12890-019-0791-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364420PMC
February 2019
1 Read

Increased expression of lung TRPV1/TRPA1 in a cough model of bleomycin-induced pulmonary fibrosis in Guinea pigs.

BMC Pulm Med 2019 Feb 4;19(1):27. Epub 2019 Feb 4.

Department of Respiratory Medicine, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No. 23rd Art Museum Backstreet, Dongcheng District, Beijing, 100010, China.

Background: Chronic cough is a difficult-to-treat comorbidity of idiopathic pulmonary fibrosis (IPF), and significantly impacts on the quality of life of patients with IPF. Transient receptor potential (TRP) channel proteins may play an important role in chronic cough. However, expression of these proteins in lung of IPF is largely unknown. Read More

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http://dx.doi.org/10.1186/s12890-019-0792-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360795PMC
February 2019
1 Read
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Oxygen desaturation during the 6-min walk test as a risk for osteoporosis in non-cystic fibrosis bronchiectasis.

BMC Pulm Med 2019 Feb 4;19(1):28. Epub 2019 Feb 4.

Department of Thoracic Medicine, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, 199 Tun-Hwa North Road, Taipei, 105, Taiwan.

Background: Osteoporosis is a common comorbidity in non-cystic fibrosis (non-CF) bronchiectasis patients. We determined whether desaturation during 6-min walk test (6MWT) can be a predictor for osteoporosis risk.

Methods: This was a retrospective cross-sectional study. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-019-0794-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360688PMC
February 2019
7 Reads

IgG4-related disease can present as recurrent spontaneous hemothorax: a case report.

BMC Pulm Med 2019 Feb 1;19(1):26. Epub 2019 Feb 1.

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Immunoglobulin G4-related disease (IgG4-RD) encompasses a group of immune-mediated disorders that are gaining increasing recognition. Pulmonary presentations are common, with four types of patterns been described on radiography, including solid nodular, bronchovascular, ground glass opacities, and alveolar interstitial. Pleural thickening and pleural effusion have also been reported. Read More

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http://dx.doi.org/10.1186/s12890-019-0785-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359758PMC
February 2019
3 Reads

Airway smooth muscle as an underutilised biomarker: a case report.

BMC Pulm Med 2019 Jan 28;19(1):24. Epub 2019 Jan 28.

Department of Thoracic Medicine, Frankston Hospital, 2 Hastings Road, Frankston, Victoria, Australia.

Background: Severe asthma and chronic obstructive pulmonary disease (COPD) can be challenging to manage, particularly when the clinical features may be similar. With the increased availability of advanced therapies for both entities, it is more important than ever to diagnose and phenotype accurately to inform appropriate treatment decisions. This case highlights the use of endobronchial biopsies to allow for histological evaluation of airways disease, and in particular the role of airway smooth muscle mass as an additional biomarker that could facilitate the diagnostic process. Read More

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http://dx.doi.org/10.1186/s12890-019-0789-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348684PMC
January 2019
1 Read

A severe case of Streptococcal pyogenes empyema following influenza A infection.

BMC Pulm Med 2019 Jan 28;19(1):25. Epub 2019 Jan 28.

Department of Clinical Infectious Diseases, Aichi Medical University Hospital, 1-1 Yazakokarimata, Nagakute, 480-1195, Aichi, Japan.

Background: Any immunological mechanisms induced by influenza virus could cause severe secondary bacterial superinfection such as those by Streptococcus pyogenes [group A streptococcus (GAS)], Streptococcus pneumoniae or Staphylococcus aureus. Over recent years, the frequency of pleural empyema has increased in children with influenza infection. We present a severe case of acute empyema caused by S. Read More

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http://dx.doi.org/10.1186/s12890-019-0787-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350381PMC
January 2019
1 Read

Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma.

BMC Pulm Med 2019 Jan 28;19(1):23. Epub 2019 Jan 28.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, PO box 30.0001, 9700, RB, Groningen, The Netherlands.

Background: Bronchial provocation is often used to confirm asthma. Dyspnea sensation, however, associates poorly with the evoked drop in FEV. Provocation tests only use the large airways parameter FEV, although dyspnea is associated with both large- and small airways dysfunction. Read More

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http://dx.doi.org/10.1186/s12890-019-0783-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348600PMC
January 2019

A prospective study of salvational intervention with ICS/LABA for reducing chronic obstructive pulmonary disease exacerbation under severe air pollution (SIRCAP) in Beijing: protocol of a multi-center randomized controlled trial.

BMC Pulm Med 2019 Jan 25;19(1):22. Epub 2019 Jan 25.

Department of Respiratory and Critical Care Medicine, Beijing Jishuitan Hospital, Beijing, China.

Background: Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality all over the world. Acute exacerbation of COPD (AECOPD) not only accelerates the progression of disease, but also causes hospital administration and death events. Epidemiologic studies have shown air pollution is a high risk factor of AECOPD. Read More

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http://dx.doi.org/10.1186/s12890-018-0771-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347780PMC
January 2019
5 Reads

CyFiT telehealth: protocol for a randomised controlled trial of an online outpatient physiotherapy service for children with cystic fibrosis.

BMC Pulm Med 2019 Jan 24;19(1):21. Epub 2019 Jan 24.

The University of Queensland School of Health and Rehabilitation Sciences, Building 84A, The University of Queensland, St Lucia, Queensland, 4072, Australia.

Background: Telehealth and telemonitoring is an emerging area of study in people with cystic fibrosis (CF), with the potential of increasing access to care, and minimising infection control risks to patients without compromising their health outcomes. To date, limited evidence is available to support the use of telehealth in paediatric population with CF in a clinical setting. This study aims to investigate the utility of a multimodal telehealth-based outpatient physiotherapy service and assess its effect on quality of life, functional exercise capacity, hospital admission and intravenous antibiotic requirements, lung function, processes of care, participation in activities of daily living, and health economics associated with operating an innovative service. Read More

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http://dx.doi.org/10.1186/s12890-019-0784-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344991PMC
January 2019
3 Reads

An evaluation of methods for the isolation of nontuberculous mycobacteria from patients with cystic fibrosis, bronchiectasis and patients assessed for lung transplantation.

BMC Pulm Med 2019 Jan 21;19(1):19. Epub 2019 Jan 21.

Microbiology Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK.

Background: RGM medium is an agar-based, selective culture medium designed for the isolation of nontuberculous mycobacteria (NTM) from the sputum of patients with cystic fibrosis (CF). We evaluated RGM medium for the detection of NTM in patients with CF (405 samples), bronchiectasis (323 samples) and other lung diseases necessitating lung transplantation (274 samples).

Methods: In total, 1002 respiratory samples from 676 patients were included in the study. Read More

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http://dx.doi.org/10.1186/s12890-019-0781-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341538PMC
January 2019
3 Reads

A single-institution study of concordance of pathological diagnoses for interstitial lung diseases between pre-transplantation surgical lung biopsies and lung explants.

BMC Pulm Med 2019 Jan 21;19(1):20. Epub 2019 Jan 21.

Department of Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: By comparing diagnoses made by pre-transplant surgical lung biopsy (SLB) and the final pathologic diagnosis of the explanted pathology (EP), we aimed to study the factors that could impact pathologic diagnoses in patients with interstitial lung disease (ILD).

Methods: We retrospectively reviewed the lung transplant database at Cleveland Clinic [01/01/2006-12/31/2013] to include all lung transplant recipients with a prior diagnosis of ILD. Two pulmonary pathologists independently reviewed each SLB and lung explant. Read More

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http://dx.doi.org/10.1186/s12890-019-0778-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341514PMC
January 2019
1 Read
2.489 Impact Factor

Development and validation of a simple-to-use clinical nomogram for predicting obstructive sleep apnea.

BMC Pulm Med 2019 Jan 18;19(1):18. Epub 2019 Jan 18.

Department of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, Shanghai, 200233, China.

Background: The high cost and low availability of polysomnography (PSG) limits the timely diagnosis of OSA. Herein, we developed and validated a simple-to-use nomogram for predicting OSA.

Methods: We collected and analyzed the cross-sectional data of 4162 participants with suspected OSA, seen at our sleep center between 2007 and 2016. Read More

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http://dx.doi.org/10.1186/s12890-019-0782-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339352PMC
January 2019
2 Reads

Bacteriologically confirmed extra pulmonary tuberculosis and treatment outcome of patients consulted and treated under program conditions in the littoral region of Cameroon.

BMC Pulm Med 2019 Jan 17;19(1):17. Epub 2019 Jan 17.

Laboratory for Public Health Research Biotechnologies, Biotechnology Centre, University of Yaoundé, Yaoundé, Cameroon.

Background: Extra-pulmonary tuberculosis (EPTB) is defined as any bacteriologically confirmed or clinically diagnosed case of TB involving organs other than the lungs. It is frequently a diagnostic and therapeutic challenge with paucity of data available. The aim of this study was to assess the prevalence of bacteriologically confirmed EPTB; to determine the most affected organs and to evaluate the therapeutic outcome of EPTB patients treated under program conditions in the littoral region of Cameroon. Read More

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http://dx.doi.org/10.1186/s12890-018-0770-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337766PMC
January 2019
8 Reads

Diagnostic yield and risk/benefit analysis of trans-bronchial lung cryobiopsy in diffuse parenchymal lung diseases: a large cohort of 699 patients.

BMC Pulm Med 2019 Jan 16;19(1):16. Epub 2019 Jan 16.

Department of Thoracic Diseases, G.B. Morgagni - L. Pierantoni Hospital, Via C. Forlanini 34, 47121, Forlì, FC, Italy.

Background: Standardization of trans-bronchial lung cryobiopsy in diffuse parenchymal lung diseases is imminent; however, the majority of published series on cryobiopsy include a limited number of patients and are characterized by several differences in procedural technical details.

Methods: This is an observational, retrospective cohort study. Aim of the study was to suggest some sampling strategies related to transbronchial cryobiopsy in the diagnostic work-up of patients with diffuse parenchymal lung diseases. Read More

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http://dx.doi.org/10.1186/s12890-019-0780-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335717PMC
January 2019
2 Reads

Are there differences among operators in false-negative rates of endosonography with needle aspiration for mediastinal nodal staging of non-small cell lung cancer?

BMC Pulm Med 2019 Jan 14;19(1):14. Epub 2019 Jan 14.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-ro 81, Gangnam-gu, Seoul, 06351, Republic of Korea.

Background: Endosonography with needle aspiration (EBUS/EUS-NA) is recommended as the first choice for mediastinal nodal assessment in non-small cell lung cancer (NSCLC). It is important to maintain adequate negative predictive value of the procedure to avoid unnecessary additional surgical staging, but there are few studies on the influence of operator-related factors including competency on false negative results. This study aims to compare the false negative rate of individual operators and whether it changes according to accumulation of experience. Read More

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http://dx.doi.org/10.1186/s12890-018-0774-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332520PMC
January 2019
1 Read

Acute exacerbation of idiopathic pulmonary fibrosis induced by pertussis: the first case report.

BMC Pulm Med 2019 Jan 14;19(1):15. Epub 2019 Jan 14.

Department of Internal Medicine, Division of Allergology and Respiratory Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.

Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe condition with limited treatment strategies. Although respiratory infection is a major cause of AE-IPF, no reports have indicated pertussis infection as a cause. Here we report two cases of pertussis infection-induced AE-IPF. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-019-0779-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332631PMC
January 2019
6 Reads

Health-related quality of life as predictor for mortality in patients treated with long-term mechanical ventilation.

BMC Pulm Med 2019 Jan 11;19(1):13. Epub 2019 Jan 11.

Department of Global Public Health and Primary Care, University in Bergen, Kalfarveien 31, 5018, Bergen, Norway.

Background: The Severe Respiratory Insufficiency (SRI) questionnaire is a specific measure of health-related quality of life (HRQoL) in patients treated with long-term mechanical ventilation (LTMV). The aim of the present study was to examine whether SRI sum scores and related subscales are associated with mortality in LTMV patients.

Methods: The study included 112 LTMV patients (non-invasive and invasive) from the Norwegian LTMV registry in Western Norway from 2008 with follow-up in August 2014. Read More

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http://dx.doi.org/10.1186/s12890-018-0768-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330471PMC
January 2019
6 Reads

Safe and effective use of nivolumab for treating lung adenocarcinoma associated with sporadic lymphangioleiomyomatosis: a rare case report.

BMC Pulm Med 2019 Jan 11;19(1):12. Epub 2019 Jan 11.

Service d'Oncologie Thoracique, Hôpital Bichat, 46 rue Henri Huchard, 75018, Paris, France.

Background: Sporadic lymphangioleiomyomatosis (LAM) is a rare form of diffuse parenchymal lung disease. PD-1 blocking antibodies constitute an essential treatment option for advanced non-small-cell lung cancer (NSCLC). The effect of immune checkpoint inhibitors in lymphangioleiomyomatosis patients with non-small cell lung cancer is unknown: concomitant symptomatic interstitial lung disease or the use of immunosuppressors was a key exclusion criterion in the original studies of immune checkpoint inhibitors, especially regarding the risk of interstitial lung disease exacerbation. Read More

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http://dx.doi.org/10.1186/s12890-018-0775-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329093PMC
January 2019
9 Reads

Characterizing idiopathic pulmonary fibrosis patients using US Medicare-advantage health plan claims data.

BMC Pulm Med 2019 Jan 10;19(1):11. Epub 2019 Jan 10.

Optum Epidemiology, 315 E. Eisenhower Parkway, Suite 305, Ann Arbor, MI, 48108, USA.

Background: Idiopathic pulmonary fibrosis (IPF) is a rare life-threating interstitial lung disease (ILD). This study characterizes demographics, health care utilization, and comorbidities among elderly IPF patients and estimates prevalence and incidence rates for selected outcomes.

Methods: Cohort study using a large US health insurance database (Optum's Medicare Advantage plan). Read More

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http://dx.doi.org/10.1186/s12890-018-0759-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327584PMC
January 2019
8 Reads

Predictive factors for relapse of cryptogenic organizing pneumonia.

BMC Pulm Med 2019 Jan 9;19(1):10. Epub 2019 Jan 9.

Division of Respiratory Diseases, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Background: Relapse of cryptogenic organizing pneumonia (COP) may lead to poor long-term prognosis and necessitates multiple rounds of steroid treatment with potential adverse effects. The objective of this study is to identify predictive factors of COP relapse by comparing demographic and clinical variables between relapse and non-relapse groups.

Methods: During 2008-2013, 33 COP patients were treated, of which 23 (69. Read More

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http://dx.doi.org/10.1186/s12890-018-0764-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327473PMC
January 2019
20 Reads

Effect of surfactant administration on outcomes of adult patients in acute respiratory distress syndrome: a meta-analysis of randomized controlled trials.

BMC Pulm Med 2019 Jan 9;19(1). Epub 2019 Jan 9.

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, No.87, Dingjiaqiao Road, Gulou District, Nanjing, 210009, China.

Introduction: Surfactant is usually deficiency in adult acute respiratory distress syndrome(ARDS) patients and surfactant administration may be a useful therapy. The aim of this study was to perform a meta-analysis of the effect of surfactant administration on outcomes of adult patients with acute respiratory distress syndrome.

Methods: PubMed, EMBASE, Medline, Cochrane database, Elsevier, Web of Science and http://clinicaltrials. Read More

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http://dx.doi.org/10.1186/s12890-018-0761-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325713PMC
January 2019
2 Reads

Objectively measured physical activity and sedentary behaviour in children with bronchiectasis: a cross-sectional study.

BMC Pulm Med 2019 Jan 8;19(1). Epub 2019 Jan 8.

Institute of Health and Biomedical Innovation, Centre for Children's Health Research, Queensland University of Technology, Brisbane, Australia.

Background: Bronchiectasis is a major contributor to respiratory morbidity and health care utilization in children and youth. Current treatment guidelines for bronchiectasis recommend participation in regular physical activity (PA) to improve aerobic fitness and quality of life (QoL). However, no previous study has assessed physical activity and sedentary behavior in this patient group, and the extent to which children with bronchiectasis meet guidelines for PA is unknown. Read More

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http://dx.doi.org/10.1186/s12890-018-0772-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323769PMC
January 2019
12 Reads

Intrapulmonary metastasis from primary pulmonary meningioma presenting as multiple cystic lesions: a case report.

BMC Pulm Med 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Background: Cystic lung lesions involving both lungs include a variety of diseases, such as pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis and pulmonary metastasis. Primary pulmonary meningioma accompanied with intrapulmonary metastasis was extremely rare and we were not aware of previous studies reporting with cystic radiological manifestation.

Case Presentation: A 64-year-old female patient was admitted to our department for a mass located in right posterior mediastinum with multiple cystic pulmonary lesions. Read More

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http://dx.doi.org/10.1186/s12890-018-0773-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325864PMC
January 2019
9 Reads

TB sequel: incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB - a study protocol.

BMC Pulm Med 2019 Jan 7;19(1). Epub 2019 Jan 7.

The Aurum Institute, Johannesburg, South Africa.

Background: Up to fifty percent of microbiologically cured tuberculosis (TB) patients may be left with permanent, moderate or severe pulmonary function impairment. Very few studies have systematically examined pulmonary outcomes in patients to understand the pathophysiologic basis and long-term socio-economic consequences of this injury. The planned multi-country, multi-centre observational TB cohort study, aims to advance the understanding of the clinical, microbiological, immunological and socio-economic risk factors affecting long-term outcome of pulmonary TB. Read More

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http://dx.doi.org/10.1186/s12890-018-0777-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323671PMC
January 2019
6 Reads

Progressive plasterer's pneumoconiosis complicated by fibrotic interstitial pneumonia: a case report.

BMC Pulm Med 2019 Jan 7;19(1). Epub 2019 Jan 7.

Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Background: Although the prevalence of pneumoconiosis has been decreasing due to improvements in working conditions and regular health examinations, occupational hygiene measures are still being established. Plasterers encounter a number of hazardous materials that may be inhaled in the absence of sufficient protection.

Case Presentation: A 64-year-old man who plastered without any dust protection for more than 40 years was referred to our hospital with suspected interstitial pneumonia. Read More

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http://dx.doi.org/10.1186/s12890-018-0776-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323823PMC
January 2019
2 Reads

A phase I, randomized, observer-blinded, single and multiple ascending-dose study to investigate the safety, pharmacokinetics, and immunogenicity of BITS7201A, a bispecific antibody targeting IL-13 and IL-17, in healthy volunteers.

BMC Pulm Med 2019 Jan 7;19(1). Epub 2019 Jan 7.

Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.

Background: Inhibition of interleukin (IL)-13, a Type 2 inflammatory mediator in asthma, improves lung function and reduces exacerbations; however, more effective therapies are needed. A subset of asthma patients also exhibits elevated IL-17, which is associated with greater disease severity, neutrophilic inflammation, and steroid resistance. BITS7201A is a novel, humanized bispecific antibody that binds and neutralizes both IL-13 and IL-17. Read More

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http://dx.doi.org/10.1186/s12890-018-0763-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323662PMC
January 2019
2 Reads

Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer.

BMC Pulm Med 2019 Jan 7;19(1). Epub 2019 Jan 7.

Rouen University Hospital, Clinique Pneumologique & CIC INSERM U 1404, F-76000, Rouen, France.

Background: EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib based theranostic agent for the molecular imaging of mutated EGFR tumours in vitro and ex vivo using a mice xenograft model and fibred confocal fluorescence microscopy (FCFM).

Methods: The fluorescent tracer was synthesized in our laboratory by addition of fluorescein to an erlotinib molecule. Read More

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http://dx.doi.org/10.1186/s12890-018-0760-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322267PMC
January 2019
2 Reads

The association between dynamic lung volume and peak oxygen uptake in a healthy general population: the HUNT study.

BMC Pulm Med 2019 Jan 6;19(1). Epub 2019 Jan 6.

K.G. Jebsen Center for Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Background: Although dynamic lung volume is not considered a limiting factor of peak oxygen uptake (VO) in healthy subjects, an association between forced expiratory lung volume in one second (FEV) and VO has been reported in a healthy population aged 69 - 77 years. We hypothesized that a corresponding association could be found in a healthy general population including young and middle-aged subjects.

Methods: In a population-based study in Norway, we investigated the association between FEV above the lower limit of normal (LLN) and VO using linear regression and assessed the ventilatory reserve (VR) in healthy subjects aged 20 - 79 years (n = 741). Read More

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http://dx.doi.org/10.1186/s12890-018-0762-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322288PMC
January 2019
2 Reads

Poor lung ultrasound score in shock patients admitted to the ICU is associated with worse outcome.

BMC Pulm Med 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Critical Care Medicine, West China school of medicine/West China hospital, Sichuan University, 37 Guoxue Avenue, Chengdu, 610041, People's Republic of China.

Background: The lung ultrasound score has been regarded as a decent semiquantitative score to measure the lung aeration loss. The score has been proven to be valuable in diagnosing and monitoring lung pathology, but no studies have demonstrated its relationship to the outcome. We aimed to investigate the relationship between the lung ultrasound score and outcome in shock patients in the Intensive Care Unit. Read More

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http://dx.doi.org/10.1186/s12890-018-0755-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318853PMC
January 2019
2 Reads

Endothelial cells from pulmonary endarterectomy specimens possess a high angiogenic potential and express high levels of hepatocyte growth factor.

BMC Pulm Med 2018 Dec 29;18(1):197. Epub 2018 Dec 29.

Department of Respirology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba City, 260-8670, Japan.

Background: Impaired angiogenesis is assumed to be an important factor in the development of chronic thromboembolic pulmonary hypertension (CTEPH). However, the role of endothelial cells (ECs) in CTEPH remains unclear. The aim of this study was to investigate the angiogenic potential of ECs from pulmonary endarterectomy (PEA) specimens. Read More

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http://dx.doi.org/10.1186/s12890-018-0769-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310963PMC
December 2018
7 Reads

Clinical expression of cystic fibrosis in a large cohort of Italian siblings.

BMC Pulm Med 2018 Dec 22;18(1):196. Epub 2018 Dec 22.

Dipartimento di Bioscienze e Territorio, Università del Molise, Isernia, Italy.

Background: A clinical heterogeneity was reported in patients with Cystic Fibrosis (CF) with the same CFTR genotype and between siblings with CF.

Methods: We investigated all clinical aspects in a cohort of 101 pairs of siblings with CF (including 6 triplets) followed since diagnosis.

Results: Severe lung disease had a 22. Read More

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http://dx.doi.org/10.1186/s12890-018-0766-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303904PMC
December 2018
8 Reads

Guideline adherence in hospital recruited and population based COPD patients.

BMC Pulm Med 2018 Dec 20;18(1):195. Epub 2018 Dec 20.

Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.

Background: Evidence from several studies show poor guideline adherence to COPD treatment, but no such study has been undertaken in Norway. The objectives of this study, was to estimate and compare the guideline adherence to COPD treatment in general population-based and hospital-recruited COPD patients, and find possible predictors of guideline adherence.

Methods: From the prospective, observational EconCOPD-study, we analysed guideline adherence for 90 population-based COPD cases compared to 245 hospital-recruited COPD patients. Read More

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http://dx.doi.org/10.1186/s12890-018-0756-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302492PMC
December 2018
1 Read

Automated computed tomographic scoring of lung disease in adults with primary ciliary dyskinesia.

BMC Pulm Med 2018 Dec 18;18(1):194. Epub 2018 Dec 18.

Radiology Department, Groupe Hospitalier Cochin-Hôtel Dieu, AP-HP, Université Paris Descartes - Sorbonne Paris Cité, Paris, France.

Background: The present study aimed to develop an automated computed tomography (CT) score based on the CT quantification of high-attenuating lung structures, in order to provide a quantitative assessment of lung structural abnormalities in patients with Primary Ciliary Dyskinesia (PCD).

Methods: Adult (≥18 years) PCD patients who underwent both chest CT and spirometry within a 6-month period were retrospectively included. Commercially available lung segmentation software was used to isolate the lungs from the mediastinum and chest wall and obtain histograms of lung density. Read More

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http://dx.doi.org/10.1186/s12890-018-0758-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299576PMC
December 2018
9 Reads
2.721 Impact Factor

Pulmonary carcinosarcoma showing an obvious response to pazopanib: a case report.

BMC Pulm Med 2018 Dec 12;18(1):193. Epub 2018 Dec 12.

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-0934, Japan.

Background: Pulmonary carcinosarcoma (PCS) is a rare primary lung malignancy and has a poor prognosis among lung tumor histological subtypes. However, an appropriate treatment strategy has not been developed for unresectable PCS.

Case Presentation: A 65-year-old man who was diagnosed with PCS was treated by surgical removal of the primary lung lesion, followed by six cycles of adjuvant chemotherapy with cisplatin plus irinotecan. Read More

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http://dx.doi.org/10.1186/s12890-018-0757-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291996PMC
December 2018
6 Reads

WISP1 mediates lung injury following hepatic ischemia reperfusion dependent on TLR4 in mice.

BMC Pulm Med 2018 Dec 6;18(1):189. Epub 2018 Dec 6.

Department of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Shanghai, 200120, China.

Background: Hepatic ischemia-reperfusion injury (IRI) is a common pathological phenomenon, which causes hepatic injury as well as remote organ injuries such as the lung. Several mediators, such as oxidative stress, Ca overload and neutrophil infiltration, have been implied in the pathogenesis of liver and remote organ injuries following reperfusion. WNT1 inducible signaling pathway protein 1 (WISP1) is an extracellular matrix protein that has been associated with the onset of several malignant diseases. Read More

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http://dx.doi.org/10.1186/s12890-018-0744-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282316PMC
December 2018
1 Read
2.489 Impact Factor