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    1147 results match your criteria BMC Pulmonary Medicine[Journal]

    1 OF 23

    Combined effects of leaks, respiratory system properties and upper airway patency on the performance of home ventilators: a bench study.
    BMC Pulm Med 2017 Nov 21;17(1):145. Epub 2017 Nov 21.
    Service des Explorations Fonctionnelles Multidisciplinaires, AP-HP, Hôpital Antoine-Béclère, 157 rue de la Porte de Trivaux, 92140, Clamart, France.
    Background: Combined effects of leaks, mechanical property of respiratory system and upper airway (UA) patency on patient-ventilator synchrony (PVA) and the level of clinically "tolerable" leaks are not well established in home ventilators.

    Methods: We comparatively assessed on a bench model, the highest leak level tolerated without inducing significant asynchrony ("critical leak") in three home ventilators (Astral 150, Trilogy 100 and Vivo 60; noted as A150, T100 and V60 respectively) subjected to three simulated diseased respiratory conditions: chronic obstructive pulmonary disease (COPD), obesity hypoventilation (OHS) and neuromuscular disorders (NMD), with both open and closed UA. Also, total leak values in the device reports were compared to the bench-measured values. Read More

    Serum concentrations of Krebs von den Lungen-6, surfactant protein D, and matrix metalloproteinase-2 as diagnostic biomarkers in patients with asbestosis and silicosis: a case-control study.
    BMC Pulm Med 2017 Nov 17;17(1):144. Epub 2017 Nov 17.
    Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chao-Yang District, Beijing, 100020, China.
    Background: Asbestosis and silicosis are progressive pneumoconioses characterized by interstitial fibrosis following exposure to asbestos or silica dust. We evaluated the potential diagnostic biomarkers for these diseases.

    Methods: The serum concentrations of Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and matrix metalloproteinase-2 (MMP-2), MMP-7, and MMP-9 were measured in 43 patients with asbestosis, 45 patients with silicosis, 40 dust-exposed workers (DEWs) without pneumoconiosis, and 45 healthy controls (HCs). Read More

    Analytical performance of Envisia: a genomic classifier for usual interstitial pneumonia.
    BMC Pulm Med 2017 Nov 17;17(1):141. Epub 2017 Nov 17.
    Veracyte, Inc., 6000 Shoreline Ct., Suite 300, South San Francisco, 94080, California, USA.
    Background: Clinical guidelines specify that diagnosis of interstitial pulmonary fibrosis (IPF) requires identification of usual interstitial pneumonia (UIP) pattern. While UIP can be identified by high resolution CT of the chest, the results are often inconclusive, making surgical lung biopsy necessary to reach a definitive diagnosis (Raghu et al., Am J Respir Crit Care Med 183(6):788-824, 2011). Read More

    Can high-flow nasal cannula reduce the rate of reintubation in adult patients after extubation? A meta-analysis.
    BMC Pulm Med 2017 Nov 17;17(1):142. Epub 2017 Nov 17.
    Department of Respiratory and Critical Care, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, China.
    Background: The effects of high flow nasal cannula (HFNC) on adult patients after extubation remain controversial. We aimed to further determine the effectiveness of HFNC in comparison to noninvasive positive pressure ventilation (NIPPV) and conventional oxygen therapy (COT).

    Methods: The Pubmed, Embase, Medline, Cochrane Central Register of Controlled Trails (CENTRAL) as well as the Information Sciences Institute (ISI) Web of Science were searched for all the controlled study comparing HFNC with NIPPV and COT in adult patients after extubation. Read More

    Efficacy and safety of nasal high-flow oxygen in COPD patients.
    BMC Pulm Med 2017 Nov 17;17(1):143. Epub 2017 Nov 17.
    Pneumology, Internal Medicine II, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
    Background: Nasal high-flow oxygen therapy (HFOT) is a novel treatment option for patients suffering from acute or chronic respiratory failure. Aim of our study was to compare safety and efficacy of HFOT with those of conventional oxygen treatment (COT) in normo- and hypercapnic COPD patients.

    Methods: A single cohort of 77 clinically stable hypoxemic patients with an indication for long-term oxygen treatment (LTOT) with or without hypercapnia successively received COT and HFOT for 60 min each, including oxygen adaption and separated by a 30 min washout phase. Read More

    COPD online-rehabilitation versus conventional COPD rehabilitation - rationale and design for a multicenter randomized controlled trial study protocol (CORe trial).
    BMC Pulm Med 2017 Nov 16;17(1):140. Epub 2017 Nov 16.
    Research Unit for Chronic Diseases and Telemedicine, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2450, Copenhagen, NV, Denmark.
    Background: Rehabilitation of patients with chronic obstructive pulmonary disease (COPD) is a key treatment in COPD. However, despite the existing evidence and a strong recommendation from lung associations worldwide, 50% of patients with COPD decline to participate in COPD rehabilitation program and 30-50% drop-out before completion. The main reasons are severe symptoms, inflexible accessibility and necessity for transportation. Read More

    Neurally Adjusted Ventilatory Assist (NAVA) or Pressure Support Ventilation (PSV) during spontaneous breathing trials in critically ill patients: a crossover trial.
    BMC Pulm Med 2017 Nov 7;17(1):139. Epub 2017 Nov 7.
    Divisao de Pneumologia, Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil.
    Background: Neurally Adjusted Ventilatory Assist (NAVA) is a proportional ventilatory mode that uses the electrical activity of the diaphragm (EAdi) to offer ventilatory assistance in proportion to patient effort. NAVA has been increasingly used for critically ill patients, but it has not been evaluated during spontaneous breathing trials (SBT). We designed a pilot trial to assess the feasibility of using NAVA during SBTs, and to compare the breathing pattern and patient-ventilator asynchrony of NAVA with Pressure Support (PSV) during SBTs. Read More

    Antibiotic perturbation of mixed-strain Pseudomonas aeruginosa infection in patients with cystic fibrosis.
    BMC Pulm Med 2017 Nov 2;17(1):138. Epub 2017 Nov 2.
    UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia.
    Background: Pulmonary exacerbations in cystic fibrosis (CF) remain poorly understood and treatment is usually targeted at Pseudomonas aeruginosa. Within Australia a predominant shared P. aeruginosa strain (AUST-02) is associated with greater treatment needs. Read More

    A rise in mean platelet volume during hospitalization for community-acquired pneumonia predicts poor prognosis: a retrospective observational cohort study.
    BMC Pulm Med 2017 Oct 30;17(1):137. Epub 2017 Oct 30.
    Department of Internal Medicine "F", Assaf Harofeh Medical Center, 70300, Zerifin, Israel.
    Background: Clinical characteristics and the prognostic significance of changes in mean platelet volume (MPV) during hospitalization for community-acquired pneumonia (CAP) have not been investigated.

    Methods: Among 976 adults hospitalized for CAP, clinical characteristics, in-hospital outcomes (transfer to the intensive care unit, treatment with mechanical ventilation, prolonged hospital stay and death), and all-cause mortality following discharge, were compared according to ΔMPV (MPV on discharge minus MPV on admission): groups A (no rising MPV, ΔMPV < 0.6 fL) and B (rising MPV, ΔMPV ≥ 0. Read More

    Knowledge gaps in patients with COPD and their proxies.
    BMC Pulm Med 2017 Oct 30;17(1):136. Epub 2017 Oct 30.
    Department of Research & Education, CIRO, Horn, the Netherlands.
    Background: Although proxies of patients with chronic obstructive pulmonary disease (COPD) need health-related knowledge to support patients in managing their disease, their current level of knowledge remains unknown. We aimed to compare health-related knowledge (generic and COPD-related knowledge) between patients with COPD and their resident proxies.

    Methods: In this cross-sectional study, we included stable patients with moderate to very severe COPD and their resident proxies (n = 194 couples). Read More

    Successful transition from Treprostinil to Selexipag in patient with severe pulmonary arterial hypertension.
    BMC Pulm Med 2017 Oct 26;17(1):135. Epub 2017 Oct 26.
    Department of Cardiology, International University of Health and Welfare Mita Hospital, Tokyo, Japan.
    Background: In this report, we describe the first successful case of transition from subcutaneous administration of treprostinil to selexipag in a patient with severe pulmonary arterial hypertension (PAH), by evaluating hemodynamic changes and exercise tolerance.

    Case Presentation: A 38-year-old female with idiopathic PAH (IPAH) had received initial triple combination therapy (macitentan PO, tadalafil PO, and treprostinil SC) and achieved excellent improvement in hemodynamics. Afterwards, due to the development of side effects from subcutaneous administration, we replaced treprostinil therapy with oral selexipag, resulting in stable hemodynamic parameters and exercise capacities. Read More

    Clinical effects of direct hemoperfusion using a polymyxin B-immobilized fiber column in clinically amyopathic dermatomyositis-associated rapidly progressive interstitial pneumonias.
    BMC Pulm Med 2017 Oct 24;17(1):134. Epub 2017 Oct 24.
    Department of Respiratory Medicine, Kumamoto University Hospital, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
    Background: Rapidly progressive interstitial pneumonias (RPIPs) associated with clinically amyopathic dermatomyositis (CADM) are highly resistant to therapy and have a poor prognosis. Multimodal therapies, including direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX-DHP), have a protective effect on RPIPs. We evaluated the effects of PMX-DHP on CADM-associated RPIPs. Read More

    Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers.
    BMC Pulm Med 2017 Oct 20;17(1):133. Epub 2017 Oct 20.
    Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
    Background: Idiopathic Pulmonary Fibrosis (IPF) is a fatal fibrotic lung disease occurring predominantly in middle-aged and older adults. The traditional diagnostic classification of IPF is based on clinical, radiological, and histopathological features. However, the considerable heterogeneity in IPF presentation suggests that differences in gene expression profiles can help to characterize and distinguish disease severity. Read More

    The value of repeat radial-probe endobronchial ultrasound-guided transbronchial biopsy after initial non-diagnostic results in patients with peripheral pulmonary lesions.
    BMC Pulm Med 2017 Oct 17;17(1):132. Epub 2017 Oct 17.
    Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Rd, Taipei, 100, Taiwan.
    Background: Radial-probe endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) is invaluable in the diagnosis of peripheral pulmonary lesions (PPLs); however, in certain instances, the procedure has to be repeated because of initial non-diagnostic procedure(s). Little if any literature has been published on this issue. Therefore, the aim of this study was to investigate the utility of repeat rEBUS-guided TBB in achieving a definitive diagnosis of PPLs. Read More

    Chronic obstructive pulmonary disease, bronchial asthma and allergic rhinitis in the adult population within the commonwealth of independent states: rationale and design of the CORE study.
    BMC Pulm Med 2017 Oct 10;17(1):131. Epub 2017 Oct 10.
    GlaxoSmithKline, Kiev, Ukraine.
    Background: Main treatable Chronic Respiratory Diseases (CRDs) like Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma (BA) and Allergic Rhinitis (AR) are underdiagnosed and undertreated worldwide. CORE study was aimed to assess the point prevalence of COPD, BA and AR in the adult population of major cities of Commonwealth of Independent States (CIS) countries - Azerbaijan, Kazakhstan, and Ukraine based on study questionnaires and/or spirometry, and to document risk factors, characterize the COPD, BA and AR population to provide a clearer "epidemiological data".

    Methods: A descriptive, cross-sectional, population-based epidemiological study conducted from 2013 to 2015 with two-stage cluster geographical randomization. Read More

    Effectiveness of pulmonary rehabilitation in patients with interstitial lung disease of different etiology: a multicenter prospective study.
    BMC Pulm Med 2017 Oct 10;17(1):130. Epub 2017 Oct 10.
    Respiratory Diseases Unit-AOU Policlinico, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, Modena, Italy.
    Background: Recent evidences show that Pulmonary Rehabilitation (PR) is effective in patients with Interstitial Lung Disease (ILD). It is still unclear whether disease severity and/or etiology might impact on the reported benefits. We designed this prospective study 1) to confirm the efficacy of rehabilitation in a population of patients with ILDs and 2) to investigate whether baseline exercise capacity, disease severity or ILD etiology might affect outcomes. Read More

    Respiratory mechanics in infants with severe bronchiolitis on controlled mechanical ventilation.
    BMC Pulm Med 2017 Oct 6;17(1):129. Epub 2017 Oct 6.
    Pediatric Intensive Care Unit, Clínica Alemana de Santiago, Vitacura, 5951, Santiago, Chile.
    Background: Analysis of respiratory mechanics during mechanical ventilation (MV) is able to estimate resistive, elastic and inertial components of the working pressure of the respiratory system. Our aim was to discriminate the components of the working pressure of the respiratory system in infants on MV with severe bronchiolitis admitted to two PICU's.

    Methods: Infants younger than 1 year old with acute respiratory failure caused by severe bronchiolitis underwent neuromuscular blockade, tracheal intubation and volume controlled MV. Read More

    Association between dementia and discharge status in patients hospitalized with pneumonia.
    BMC Pulm Med 2017 Oct 6;17(1):128. Epub 2017 Oct 6.
    Department of Respiratory Medicine, Graduate School of Medicine, Tokyo, Japan.
    Background: Pneumonia is the most common cause of death in patients with dementia, but the outcomes of patients with dementia hospitalized with pneumonia are poorly understood. We sought to illuminate the association between dementia and in-hospital mortality and discharge status in patients hospitalized with pneumonia.

    Methods: We used the Diagnosis Procedure Combination database, a national inpatient database in Japan, to identify retrospectively patients aged ≥60 years admitted to hospital with pneumonia during the study period of May 1, 2010 to March 31, 2014. Read More

    The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicentre randomized controlled trial (VENIM).
    BMC Pulm Med 2017 Sep 20;17(1):127. Epub 2017 Sep 20.
    Emergency Department, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, China.
    Background: Acute respiratory failure (ARF) is still one of the most severe complications in immunocompromised patients. Our previous systematic review showed noninvasive mechanical ventilation (NIV) reduced mortality, length of hospitalization and ICU stay in AIDS/hematological malignancy patients with relatively less severe ARF, compared to invasive mechanical ventilation (IMV). However, this systematic review was based on 13 observational studies and the quality of evidence was low to moderate. Read More

    A qualitative study to identify parents' perceptions of and barriers to asthma management in children from South Asian and White British families.
    BMC Pulm Med 2017 Sep 20;17(1):126. Epub 2017 Sep 20.
    Faculty of Health and Social Studies, Mary Seacole Research Centre, De Montfort University, The Gateway, Leicester, LE1 9BH, UK.
    Background: Over one million children receive treatment for asthma in the UK. South Asian children experience excess morbidity and higher rates of hospitalization than the White population. This study aimed to explore perceptions and experiences of asthma and asthma management in British South Asian and White British families, to identify barriers to optimal management and to inform culturally appropriate interventions to improve management. Read More

    The effect of sedation and/or analgesia as rescue treatment during noninvasive positive pressure ventilation in the patients with Interface intolerance after Extubation.
    BMC Pulm Med 2017 Sep 15;17(1):125. Epub 2017 Sep 15.
    Department of Respiratory and Critical Care, No.37 Guoxue Alley, Chengdu, 610041, China.
    Background: Sedation and/or analgesia can relieve the patient-ventilator asynchrony. However, whether sedation and/or analgesia can benefit the clinical outcome of the patients with interface intolerance is still unclear.

    Methods: A retrospective study was performed on patients with interface intolerance who received noninvasive positive pressure ventilation (NIPPV) after extubation in seven intensive care units (ICU) of West China Hospital, Sichuan University. Read More

    Unmet needs in the treatment of idiopathic pulmonary fibrosis-insights from patient chart review in five European countries.
    BMC Pulm Med 2017 Sep 15;17(1):124. Epub 2017 Sep 15.
    Regional Referral Centre for Rare Lung Diseases, University of Catania, Catania, Italy.
    Background: Two antifibrotic drugs, pirfenidone and nintedanib, are approved by the European Medicines Agency and the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF). In this analysis, treatment patterns of European patients with IPF were investigated to understand antifibrotic prescribing and identify unmet needs in IPF treatment practice.

    Methods: Between February and March 2016, respiratory physicians from France, Germany, Italy, Spain, and the UK participated in an online questionnaire designed to collect information on IPF treatment patterns in patients under their care. Read More

    Clinical and radiological characteristics of patients with late-onset severe restrictive lung defect after hematopoietic stem cell transplantation.
    BMC Pulm Med 2017 Sep 7;17(1):123. Epub 2017 Sep 7.
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Background: Late-onset noninfectious pulmonary complications (LONIPCs), which occur more than 3 months after allogeneic hematopoietic stem cell transplantation (HSCT), are major causes of morbidity and mortality after transplantation. Among LONIPCs, we occasionally treat patients with late-onset severe restrictive lung defect after HSCT; however, its clinical features have not been fully elucidated.

    Methods: A retrospective chart review of a single center on cases of late-onset severe restrictive lung defect after HSCT was performed. Read More

    Exploring efficacy and safety of oral Pirfenidone for progressive, non-IPF lung fibrosis (RELIEF) - a randomized, double-blind, placebo-controlled, parallel group, multi-center, phase II trial.
    BMC Pulm Med 2017 Sep 6;17(1):122. Epub 2017 Sep 6.
    Department of Internal Medicine II, University of Giessen-Marburg Lung Center, Justus-Liebig University Giessen, Giessen, Germany.
    Background: Pirfenidone is currently approved in the EU for the treatment of mild to moderate idiopathic pulmonary fibrosis (IPF) and offers a beneficial risk-benefit profile. However, there are several other, progressive fibrotic lung diseases, in which conventional anti-inflammatory therapy is not sufficiently effective and antifibrotic therapies may offer a novel treatment option.

    Methods/design: We designed a study protocol for inclusion of patients with progressive fibrotic lung disease despite conventional anti-inflammatory therapy (EudraCT 2014-000861-32). Read More

    Pulmonary challenge with carbon nanoparticles induces a dose-dependent increase in circulating leukocytes in healthy males.
    BMC Pulm Med 2017 Sep 6;17(1):121. Epub 2017 Sep 6.
    Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Room F-5-260, Amsterdam, The Netherlands.
    Background: Inhalation of particulate matter, as part of air pollution, is associated with increased morbidity and mortality. Nanoparticles (< 100 nm) are likely candidates for triggering inflammatory responses and activation of coagulation pathways because of their ability to enter lung cells and pass bronchial mucosa. We tested the hypothesis that bronchial segmental instillation of carbon nanoparticles causes inflammation and activation of coagulation pathways in healthy humans in vivo. Read More

    Propensity score analysis of lung cancer risk in a population with high prevalence of non-smoking related lung cancer.
    BMC Pulm Med 2017 Sep 6;17(1):120. Epub 2017 Sep 6.
    Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
    Background: Lung cancer has been the leading cause of cancer-related mortality worldwide among both men and women in recent years. There is an increase in the incidence of nonsmoking-related lung cancer in recent years. The purpose of the present study was to investigate multiple potential risk factors for nonsmoking-related lung cancer among Asian Ethnic Groups. Read More

    Reference Equations for the Six-Minute Walk Distance in the Healthy Chinese Han Population, Aged 18-30 Years.
    BMC Pulm Med 2017 Aug 29;17(1):119. Epub 2017 Aug 29.
    Department of General and Intensive Care Medical, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhe Jiang Province, China.
    Background: The six-minute walk test (6MWT) is a safe, simple, inexpensive tool for evaluating the functional exercise capacity. However, there is a lack of standard reference equations for the six-minute walk distance (6MWD) in the healthy Chinese Han population with an age of 18-30 years. The aims of the present study were as follows: 1) to measure the anthropometric data and the walking distance in a sample of healthy Chinese Han population, aged 18-30 years; 2) to construct reference equations for the 6MWD; 3) to compare the measured 6MWD of our cohort with previously published equations. Read More

    Reference values of fractional excretion of exhaled nitric oxide among non-smokers and current smokers.
    BMC Pulm Med 2017 Aug 25;17(1):118. Epub 2017 Aug 25.
    Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Background: Fractional exhaled nitric oxide (FENO) is used to assess of airway inflammation; diagnose asthma and monitor adherence to advised therapy. Reliable and accurate reference values for FENO are needed for both non-smoking and current smoking adults in the clinical setting. The present study was performed to establish reference adult FENO values among never-smokers, former smokers and current smokers. Read More

    Influence of resting lung diffusion on exercise capacity in patients with COPD.
    BMC Pulm Med 2017 Aug 25;17(1):117. Epub 2017 Aug 25.
    Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ, USA.
    Background: Lung diffusing capacity for carbon monoxide (DLCO) gives an overall assessment of functional lung surface area for gas exchange and can be assessed using various methods. DLCO is an important factor in exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). We investigated if the intra-breath (IBDLCO) method may give a more sensitive measure of available gas exchange surface area than the more typical single breath (SBDLCO) method and if COPD subjects with the largest resting DLCO relative to pulmonary blood flow (Qc) would have a more preserved exercise capacity. Read More

    Volatile organic compounds in ventilated critical care patients: a systematic evaluation of cofactors.
    BMC Pulm Med 2017 Aug 22;17(1):116. Epub 2017 Aug 22.
    Department of Anaesthesiology, Intensive Care and Pain Therapy, Centre of Breath Research, Saarland University Medical Centre, Kirrberger Strasse 100, 66421, Homburg (Saar), Germany.
    Background: Expired gas (exhalome) analysis of ventilated critical ill patients can be used for drug monitoring and biomarker diagnostics. However, it remains unclear to what extent volatile organic compounds are present in gases from intensive care ventilators, gas cylinders, central hospital gas supplies, and ambient air. We therefore systematically evaluated background volatiles in inspired gas and their influence on the exhalome. Read More

    Effect of counselling during pulmonary rehabilitation on self-determined motivation towards physical activity in people with chronic obstructive pulmonary disease - protocol of a mixed methods study.
    BMC Pulm Med 2017 Aug 17;17(1):115. Epub 2017 Aug 17.
    Zurich University of Applied Sciences, Institute for Physiotherapy, Technikumstrasse 71, 8401, Winterthur, Switzerland.
    Background: Physical activity promotion in people with Chronic Obstructive Pulmonary Disease (COPD) is focus of research and public health. Patient-centred interventions like counselling are promising approaches to help patients reducing sedentary behaviour. Aim of the present study is to investigate if a physical activity counselling program during pulmonary rehabilitation increases physical activity level in daily life in people with COPD. Read More

    A multi-center randomized, controlled, open-label trial evaluating the effects of eosinophil-guided corticosteroid-sparing therapy in hospitalised patients with COPD exacerbations - The CORTICO steroid reduction in COPD (CORTICO-COP) study protocol.
    BMC Pulm Med 2017 Aug 15;17(1):114. Epub 2017 Aug 15.
    Department of Internal Medicine, Herlev and Gentofte University Hospital, Hellerup, Denmark.
    Background: The most commonly applied treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a 5-day course of high-dose systemic corticosteroids. However, this treatment has not been shown to reduce mortality and can potentially have serious side effects. Recent research has shown that, presumably, only a subgroup of COPD patients identifieable by blood eosinophil count benefit from a rescue course of prednisolone. Read More

    FEV1 and FVC and systemic inflammation in a spinal cord injury cohort.
    BMC Pulm Med 2017 Aug 15;17(1):113. Epub 2017 Aug 15.
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 401 Park Drive, Landmark Center 3rd Floor West, Boston, MA, 02215, USA.
    Background: Systemic inflammation has been associated with reduced pulmonary function in individuals with and without chronic medical conditions. Individuals with chronic spinal cord injury (SCI) have clinical characteristics that promote systemic inflammation and also have reduced pulmonary function. We sought to assess the associations between biomarkers of systemic inflammation with pulmonary function in a chronic SCI cohort, adjusting for other potential confounding factors. Read More

    Serological and morphological prognostic factors in patients with interstitial pneumonia with autoimmune features.
    BMC Pulm Med 2017 Aug 14;17(1):111. Epub 2017 Aug 14.
    Department of Respiratory Medicine, Kurashiki Central Hospital, Kurashiki, Japan.
    Background: To identify the prognostic factors for survival in patients with interstitial pneumonia with autoimmune features (IPAF) who meet the serological domain of the IPAF criteria.

    Methods: We retrospectively analysed 99 IPAF patients who met the serological domain and were hospitalised at the Respiratory Medicine Unit of Kurashiki Central Hospital from 1999 to 2015. The high-resolution computed tomography findings were usual interstitial pneumonia (UIP; n = 1), non-specific interstitial pneumonia (NSIP; n = 63), NSIP with organizing pneumonia (OP) overlap (n = 15), and OP (n = 20). Read More

    Association between Charlson comorbidity index score and outcome in patients with stage IIIB-IV non-small cell lung cancer.
    BMC Pulm Med 2017 Aug 15;17(1):112. Epub 2017 Aug 15.
    Cancer Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xicheng District, Beijing, 100050, China.
    Background: This retrospective study investigated the association between the Charlson comorbidity index (CCI) score and the survival of patients with stage IIIB-IV (advanced, non-resectable) non-small cell lung cancer (NSCLC) who also did not have gene mutations in epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK).

    Methods: The records of 165 patients (28-80 y, median 61 y) who met the above criteria and were admitted to Beijing Friendship Hospital Capital Medical University from 1 May 2010 to 1 October 2014were reviewed. Associations between baseline variables and the CCI score were assessed via univariate and multivariate logistic regression analysis. Read More

    Cathepsin-S degraded decorin are elevated in fibrotic lung disorders - development and biological validation of a new serum biomarker.
    BMC Pulm Med 2017 Aug 9;17(1):110. Epub 2017 Aug 9.
    Nordic Bioscience A/S, Herlev, Denmark.
    Background: Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnover and tissue homeostasis. Degradation of decorin might disturb normal tissue homeostasis contributing to extracellular matrix remodeling diseases. Here, we present the development and validation of a competitive enzyme-linked immunosorbent assay (ELISA) quantifying a specific fragment of degraded decorin, which has potential as a novel non-invasive serum biomarker for fibrotic lung disorders. Read More

    Prognostic nomogram for inpatients with asthma exacerbation.
    BMC Pulm Med 2017 Aug 4;17(1):108. Epub 2017 Aug 4.
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Background: Asthma exacerbation may require a visit to the emergency room as well as hospitalization and can occasionally be fatal. However, there is limited information about the prognostic factors for asthma exacerbation requiring hospitalization, and no methods are available to predict an inpatient's prognosis. We investigated the clinical features and factors affecting in-hospital mortality of patients with asthma exacerbation and generated a nomogram to predict in-hospital death using a national inpatient database in Japan. Read More

    Diagnostic value of medical thoracoscopy in malignant pleural effusion.
    BMC Pulm Med 2017 Aug 4;17(1):109. Epub 2017 Aug 4.
    Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
    Background: Medical thoracoscopy has been shown to be an efficacious procedure in diagnosing unexplained exudative pleural effusions with excellent safety. This study aimed to assess the diagnostic significance of thoracoscopy in the management of patients with malignant pleural effusion (MPE).

    Methods: Consecutive patients with malignant pleural effusion were retrospectively reviewed, and their demographic, radiographic, thoracoscopic and histological data were collected. Read More

    Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and sarcoidosis: more pathological findings in the same chest CT, or a single pathological pathway?
    BMC Pulm Med 2017 Jul 28;17(1):107. Epub 2017 Jul 28.
    Respiratory Unit, Ospedale San Paolo, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.
    Background: Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome, lymphangioleiomyomatosis/tuberous sclerosis complex (LAM-TSC), and sarcoidosis are three rare diseases. Here we present, to the best of our knowledge, the first description of a patient with the coexistence of these three diseases.

    Case Presentation: A 47-year-old woman affected by LAM-TSC and primary biliary cirrosis/autoimmune hepatitis overlap syndrome. Read More

    Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis.
    BMC Pulm Med 2017 Jul 27;17(1):106. Epub 2017 Jul 27.
    Division of Pulmonary Medicine, University of Washington School of Medicine, Seattle, WA, USA.
    Background: The role of air pollution in increasing susceptibility to respiratory tract infections in the cystic fibrosis (CF) population has not been well described. We recently demonstrated that chronic PM2.5 exposure is associated with an increased risk of initial Pseudomonas aeruginosa acquisition in young children with CF. Read More

    Intravenous superoxide dismutase as a protective agent to prevent impairment of lung function induced by high tidal volume ventilation.
    BMC Pulm Med 2017 Jul 26;17(1):105. Epub 2017 Jul 26.
    School of Medicine, Fu Jen Catholic University, No. 510, Zhongzheng Rd., Xinzhuang Dist, New Taipei City, 24205, Taiwan.
    Background: Positive-pressure mechanical ventilation is essential in assisting patients with respiratory failure in the intensive care unit and facilitating oxygenation in the operating room. However, it was also recognized as a primary factor leading to hospital-acquired pulmonary dysfunction, in which pulmonary oxidative stress and lung inflammation had been known to play important roles. Cu/Zn superoxide dismutase (SOD) is an important antioxidant, and possesses anti-inflammatory capacity. Read More

    Prognosis and longitudinal changes of physical activity in idiopathic pulmonary fibrosis.
    BMC Pulm Med 2017 Jul 25;17(1):104. Epub 2017 Jul 25.
    Pulmonary Research Institute at LungenClinic Grosshansdorf, Woehrendamm 80, 22927, Grosshansdorf, Germany.
    Background: Physical activity (PA) is associated with disease severity in idiopathic pulmonary fibrosis (IPF), but longitudinal studies evaluating its prognostic value and changes over time are lacking.

    Methods: We measured PA (steps per day, SPD) in a cohort of 46 IPF-patients (mean age, 67 years; mean FVC, 76.1%pred. Read More

    Successful rescue combination of extracorporeal membrane oxygenation, high-frequency oscillatory ventilation and prone positioning for the management of severe methicillin-resistant Staphylococcus aureus pneumonia complicated by pneumothorax: a case report and literature review.
    BMC Pulm Med 2017 Jul 20;17(1):103. Epub 2017 Jul 20.
    Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.
    Background: To describe the experience of combination therapy with extracorporeal membrane oxygenation(ECMO), high-frequency oscillatory ventilation(HFOV) and prone positioning in treating severe respiratory failure caused by community acquired methicillin resistant Staphylococcus aureus(CA-MRSA).

    Case Presentation: A 30-year-old female presented with fever and dyspnea for 3 days. She was diagnosed CA-MRSA pneumonia complicated by severe respiratory failure, pneumothorax and neutropenia. Read More

    Analysis of long term CD4+CD25highCD127- T-reg cells kinetics in peripheral blood of lung transplant recipients.
    BMC Pulm Med 2017 Jul 18;17(1):102. Epub 2017 Jul 18.
    Department of Internal Medicine, University of Pavia, Pavia, Italy.
    Background: The role of CD4(+)CD25(high)CD127(-) T-reg cells in solid-organ Transplant (Tx) acceptance has been extensively studied. In previous studies on kidney and liver recipients, peripheral T-reg cell counts were associated to graft survival, while in lung Tx, there is limited evidence for similar findings. This study aims to analyze long term peripheral kinetics of T-reg-cells in a cohort of lung recipients and tests its association to several clinical variables. Read More

    Type 2 diabetes is associated with an increased prevalence of respiratory symptoms as compared to the general population.
    BMC Pulm Med 2017 Jul 17;17(1):101. Epub 2017 Jul 17.
    Unit of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, Strada Le Grazie, 8 -, 37134, Verona, Italy.
    Background: To estimate the prevalence of respiratory symptoms in individuals with type 2 diabetes, as compared to the general population.

    Methods: Between 2007 and 2010 the screening questionnaire of GEIRD (Gene Environment Interactions in Respiratory Diseases) study was administered to two samples of Verona general population, aged respectively 45-64 years and 65-84 years, and to a convenience sample of individuals with type 2 diabetes, consequently recruited at the local Diabetes Centre. Ninety-four and 165 people with type 2 diabetes, aged respectively 45-64 and 65-84 years, were compared with 676 and 591 subjects in the same age range from the general population. Read More

    Monitoring clinical and microbiological evolution of a cystic fibrosis patient over 26 years: experience of a Brazilian CF Centre.
    BMC Pulm Med 2017 Jul 14;17(1):100. Epub 2017 Jul 14.
    Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Burkholderia cepacia complex is a group of opportunistic pathogens in cystic fibrosis (CF) patients believed to be associated with poor prognosis and patient-to-patient transmissibility. Little is known about clinical outcomes after B. vietnamiensis chronic colonization/infection. Read More

    Patient preferences for dry powder inhaler attributes in asthma and chronic obstructive pulmonary disease in France: a discrete choice experiment.
    BMC Pulm Med 2017 Jul 6;17(1):99. Epub 2017 Jul 6.
    Respiratory and Intensive Care Medicine, Cochin Hospital Group, AP-HP, University Paris Descartes, Paris, France.
    Background: Dry powder inhalers (DPIs) are often used in asthma and chronic obstructive pulmonary disease (COPD) therapies. Using the discrete choice experiment (DCE) methodology, this study conducted in France was designed to assess patients' preferences for different attributes of DPIs.

    Methods: Attributes of DPIs were defined based on a literature review, patient focus group discussions and interviews with healthcare professionals (qualitative phase of the study). Read More

    Regulating autonomic nervous system homeostasis improves pulmonary function in rabbits with acute lung injury.
    BMC Pulm Med 2017 Jul 3;17(1):98. Epub 2017 Jul 3.
    Department of Anesthesiology, the Second Affiliated Hospital of Harbin Medical University, the HeiLongJiang Province key laboratory on Anesthesiology and Critical Care Medicine, NO.246 of Xuefu Road, Nangang District, Harbin, Heilongjiang Province, 150081, China.
    Background: This study aimed to investigate the effects of regulating autonomic nervous system (ANS) homeostasis by inhibiting sympathetic hyperactivity and/or enhancing parasympathetic activity on pulmonary inflammation and functional disturbance.

    Methods: An animal model of acute lung injury (ALI) was established in rabbits by an intratracheal injection of hydrochloric acid (HCl) in rabbits. Animals in control groups were received saline or HCl only, and the others received both HCl and followed treatments: vagus nerve stimulation (VNS), intravenous injection of tetrahydroaminoacridine (THA), or stellate ganglion block (SGB). Read More

    Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia.
    BMC Pulm Med 2017 Jun 30;17(1):97. Epub 2017 Jun 30.
    Department of Pediatrics, Södersjukhuset, Sachs' Children and Youth Hospital, 118 83, Stockholm, Sweden.
    Background: Bronchopulmonary dysplasia (BPD) is a strong risk factor for respiratory morbidity in children born preterm. Our aims were to evaluate lung function in adolescents born preterm with and without a history of BPD, and to assess lung function change over time from school age.

    Methods: Fifty-one individuals born in Stockholm, Sweden between gestational ages 24 to 31 weeks (23 neonatally diagnosed with respiratory distress syndrome (RDS) but not BPD, and 28 graded as mild (n = 17), moderate (n = 7) or severe (n = 4) BPD) were examined in adolescence (13-17 years of age) using spirometry, impulse oscillometry (IOS), plethysmography, and ergospirometry. Read More

    Prevalence and associated risk factors of chronic bronchitis in First Nations people.
    BMC Pulm Med 2017 Jun 29;17(1):95. Epub 2017 Jun 29.
    Canadian Centre for Health and Safety in Agriculture, Royal University Hospital, 104, Clinic Place, Saskatoon, SK, S7N 2Z4, Canada.
    Background: Inadequate housing, low family income, household smoking, personal smoking status, and poor schooling are some of the conditions that have been significantly associated with the prevalence and incidence of chronic bronchitis. The aim of the current study was to determine the prevalence of chronic bronchitis (CB) and associated risk factors among First Nations people.

    Methods: An interviewer-administered survey was conducted as part of the First Nations Lung Health Project in 2012 and 2013 with 874 individuals from 406 households in two First Nations communities located in the province of Saskatchewan, Canada. Read More

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