1,326 results match your criteria BMC Pulmonary Medicine[Journal]


Obliterative bronchiolitis associated with rheumatoid arthritis: analysis of a single-center case series.

BMC Pulm Med 2018 Jun 22;18(1):105. Epub 2018 Jun 22.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.

Background: Rheumatoid arthritis (RA) is a systemic autoimmune condition characterized by erosive inflammation of the joints. One rare pulmonary manifestation is obliterative bronchiolitis (OB), a small airways disease characterized by the destruction of bronchiolar epithelium and airflow obstruction.

Methods: We retrospectively reviewed the clinical data of patients with rheumatoid arthritis-associated obliterative bronchiolitis (RA-OB) from 01/01/2000 to 12/31/2015. Read More

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Heparin-binding protein in sputum as a marker of pulmonary inflammation, lung function, and bacterial load in children with cystic fibrosis.

BMC Pulm Med 2018 Jun 20;18(1):104. Epub 2018 Jun 20.

Department of Clinical Sciences Lund, Division of Infection Medicine, BMC B14, Lund University, Skåne University Hospital, Tornavägen 10, SE-22184, Lund, Sweden.

Background: Cystic fibrosis (CF) is associated with bacterial pulmonary infections and neutrophil-dominated inflammation in the airways. The aim of this study was to evaluate the neutrophil-derived protein Heparin-binding protein (HBP) as a potential sputum marker of airway inflammation and bacterial load.

Methods: Nineteen CF patients, aged 6-18 years, were prospectively followed for 6 months with sputum sampling at every visit to the CF clinic. Read More

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June 2018
2 Reads

Earlier smoking after waking and the risk of asthma: a cross-sectional study using NHANES data.

BMC Pulm Med 2018 Jun 18;18(1):102. Epub 2018 Jun 18.

Master of Public Health Program, Department of Population Health, University of North Dakota, 1301 North Columbia Rd. Stop 9037, Grand Forks, ND, 58202, USA.

Background: Recent research shows that nicotine dependence conveys additional health risks above and beyond smoking behavior. The current study examines whether smoking within 5 min of waking, an indicator of nicotine dependence, is independently associated with asthma outcomes.

Methods: Data were drawn from five pooled cross-sectional waves (2005-14) of NHANES, and the final sample consisted of N = 4081 current adult smokers. Read More

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"Velcro-type" crackles predict specific radiologic features of fibrotic interstitial lung disease.

BMC Pulm Med 2018 Jun 18;18(1):103. Epub 2018 Jun 18.

Division of Respiratory Medicine, University Hospital "A. Gemelli", Catholic University of Sacred Heart, Rome, Italy.

Background: "Velcro-type" crackles on chest auscultation are considered a typical acoustic finding of Fibrotic Interstitial Lung Disease (FILD), however whether they may have a role in the early detection of these disorders has been unknown. This study investigated how "Velcro-type" crackles correlate with the presence of distinct patterns of FILD and individual radiologic features of pulmonary fibrosis on High Resolution Computed Tomography (HRCT).

Methods: Lung sounds were digitally recorded from subjects immediately prior to undergoing clinically indicated chest HRCT. Read More

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Activation and polarization of circulating monocytes in severe chronic obstructive pulmonary disease.

BMC Pulm Med 2018 Jun 15;18(1):101. Epub 2018 Jun 15.

Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.

Background: The ability of circulating monocytes to develop into lung macrophages and promote lung tissue damage depends upon their phenotypic pattern of differentiation and activation. Whether this phenotypic pattern varies with COPD severity is unknown. Here we characterize the activation and differentiation status of circulating monocytes in patients with moderate vs. Read More

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Acute effects of combined exercise and oscillatory positive expiratory pressure therapy on sputum properties and lung diffusing capacity in cystic fibrosis: a randomized, controlled, crossover trial.

BMC Pulm Med 2018 Jun 14;18(1):99. Epub 2018 Jun 14.

Division of Occupational and Environmental Medicine, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

Background: Regular airway clearance by chest physiotherapy and/or exercise is critical to lung health in cystic fibrosis (CF). Combination of cycling exercise and chest physiotherapy using the Flutter® device on sputum properties has not yet been investigated.

Methods: This prospective, randomized crossover study compared a single bout of continuous cycling exercise at moderate intensity (experiment A, control condition) vs a combination of interval cycling exercise plus Flutter® (experiment B). Read More

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June 2018
2 Reads

Comparison of peak inspiratory flow rate via the Breezhaler®, Ellipta® and HandiHaler® dry powder inhalers in patients with moderate to very severe COPD: a randomized cross-over trial.

BMC Pulm Med 2018 Jun 14;18(1):100. Epub 2018 Jun 14.

Novartis Pharma AG, Basel, Switzerland.

Background: The chronic and progressive nature of chronic obstructive pulmonary disease (COPD) requires self-administration of inhaled medication. Dry powder inhalers (DPIs) are increasingly being used for inhalation therapy in COPD. Important considerations when selecting DPIs include inhalation effort required and flow rates achieved by patients. Read More

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Physical activity and sedentary time are related to clinically relevant health outcomes among adults with obstructive lung disease.

BMC Pulm Med 2018 Jun 7;18(1):98. Epub 2018 Jun 7.

Faculty of Medicine and Dentistry, University of Alberta, and G.F. Macdonald Centre for Lung Health, 3-135 Clinical Sciences Building, 11304 - 83 Avenue, Edmonton, Alberta, T6G 2J3, Canada.

Background: The purpose of the current study was to determine the association between sedentary time and physical activity with clinically relevant health outcomes among adults with impaired spirometry and those with or without self-reported obstructive lung disease (asthma or COPD).

Methods: Data from participants of the Canadian Longitudinal Study on Aging were used for analysis (n = 4156). Lung function was assessed using spirometry. Read More

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Pulmonary sequestration in adults: a retrospective review of resected and unresected cases.

BMC Pulm Med 2018 Jun 5;18(1):97. Epub 2018 Jun 5.

Division of Pulmonary and Critical Care Medicine, Gonda 18 South, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.

Background: Pulmonary sequestration (PS) is a form of congenital pulmonary malformation that is generally diagnosed in childhood or adolescence and usually resected when diagnosed. We aim to identify the clinical presentation and course of patients diagnosed to have PS during adulthood.

Methods: Using a computer-assisted search of Mayo clinic medical records, we identified adult patients with PS diagnosed between 1997 and 2016. Read More

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June 2018
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Risk factors for interstitial lung disease: a 9-year Nationwide population-based study.

BMC Pulm Med 2018 Jun 4;18(1):96. Epub 2018 Jun 4.

Department of Occupational & Environmental Medicine, Sungso Hospital, Andong, Republic of Korea.

Background: Understanding the risk factors that are associated with the development of interstitial lung disease might have an important role in understanding the pathogenetic mechanism of interstitial lung disease as well as prevention. We aimed to determine independent risk factors of interstitial lung disease development.

Methods: This was a retrospective cohort study with nationwide population-based 9-year longitudinal data. Read More

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June 2018
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Delayed isolation of smear-positive pulmonary tuberculosis patients in a Japanese acute care hospital.

BMC Pulm Med 2018 May 31;18(1):94. Epub 2018 May 31.

Muribushi Okinawa Project for Teaching Hospitals, Okinawa, Okinawa Prefecture, Japan.

Background: Active pulmonary tuberculosis (TB) is associated with intra-hospital spread of the disease. Expeditious diagnosis and isolation are critical for infection control. However, factors that lead to delayed isolation of smear-positive pulmonary TB patients, especially among the elderly, have not been reported. Read More

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May 2018
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Global lung function initiative 2012 reference values for spirometry in Asian Americans.

BMC Pulm Med 2018 May 31;18(1):95. Epub 2018 May 31.

Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100730, China.

Background: Spirometry reference values specifically designed for Asian Americans are currently unavailable. The performance of Global Lung Function Initiative 2012 (GLI-2012) equations on assessing spirometry in Asian Americans has not been evaluated. This study aimed to assess the fitness of relevant GLI-2012 equations for spirometry in Asian Americans. Read More

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Effectiveness of a standardized electronic admission order set for acute exacerbation of chronic obstructive pulmonary disease.

BMC Pulm Med 2018 May 30;18(1):93. Epub 2018 May 30.

Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Background: Variation in hospital management of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may prolong length of stay, increasing the risk of hospital-acquired complications and worsening quality of life. We sought to determine whether an evidence-based computerized AECOPD admission order set could improve quality and reduce length of stay.

Methods: The order set was designed by a provincial COPD working group and implemented voluntarily among three physician groups in a Canadian tertiary-care teaching hospital. Read More

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Stability of gene expression by primary bronchial epithelial cells over increasing passage number.

BMC Pulm Med 2018 May 29;18(1):91. Epub 2018 May 29.

Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA.

Background: An increasing number of studies using primary human bronchial epithelial cells (BECs) have reported intrinsic differences in the expression of several genes between cells from asthmatic and non-asthmatic donors. The stability of gene expression by primary BECs with increasing cell passage number has not been well characterized.

Methods: To determine if expression by primary BECs from asthmatic and non-asthmatic children of selected genes associated with airway remodeling, innate immune response, immunomodulatory factors, and markers of differentiated airway epithelium, are stable over increasing cell passage number, we studied gene expression patterns in passages 1, 2, 3, 4, and 5 BECs from asthmatic (n = 6) and healthy (n = 6) subjects that were differentiated at an air-liquid interface. Read More

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May 2018
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Mixed pneumonic plague and nosocomial MDR-bacterial infection of lung: a rare case report.

BMC Pulm Med 2018 May 29;18(1):92. Epub 2018 May 29.

Plague Unit- Institut Pasteur de Madagascar, BP1274 Ambatofotsikely, 101, Antananarivo, Madagascar.

Background: Plague is a life-threatening disease caused by the bacterium, Yersinia pestis. Madagascar is the leading country for human plague cases worldwide. Human plague is a serious disease, particularly in its septicaemic and pneumonic forms. Read More

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May 2018
1 Read

The level of lipopolysaccharide-binding protein is elevated in adult patients with obstructive sleep apnea.

BMC Pulm Med 2018 May 29;18(1):90. Epub 2018 May 29.

Department of Respiratory Medicine in Zhejiang Hospital, 12 Lingyin Road, Xihu District, Hangzhou, 310013, Zhejiang Province, China.

Background: lipopolysaccharide-binding protein (LBP) has been to be a surrogate marker of inflammation in OSA. This study aimed to test the hypothesis that the concentration of LBP is elevated in adult patients with obstructive sleep apnea (OSA).

Methods: A total of 90 patients were enrolled into the study, 50 subjects were divided into OSA groups and 40 in healthy control according to PSG examination. Read More

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May 2018
2 Reads

Effect of altering breathing frequency on maximum voluntary ventilation in healthy adults.

BMC Pulm Med 2018 May 24;18(1):89. Epub 2018 May 24.

Exercise Physiology Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 37-131 CHS Building, Los Angeles, CA, 90095, USA.

Background: Compared to other pulmonary function tests, there is a lack of standardization regarding how a maximum voluntary ventilation (MVV) maneuver is performed. Specifically, little is known about the variation in breathing frequency (f) and its potential impact on the accuracy of test results. This study examines the effect of several preselected values for f and one self-selected f (f) on MVV. Read More

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May 2018
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Six underlying health conditions strongly influence mortality based on pneumonia severity in an ageing population of Japan: a prospective cohort study.

BMC Pulm Med 2018 May 23;18(1):88. Epub 2018 May 23.

Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.

Background: Mortality prediction of pneumonia by severity scores in patients with multiple underlying health conditions has not fully been investigated. This prospective cohort study is to identify mortality-associated underlying health conditions and to analyse their influence on severity-based pneumonia mortality prediction.

Methods: Adult patients with community-acquired pneumonia or healthcare-associated pneumonia (HCAP) who visited four community hospitals between September 2011 and January 2013 were enrolled. Read More

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May 2018
2 Reads

Outcomes of lung transplantation in adults with bronchiectasis.

BMC Pulm Med 2018 May 22;18(1):82. Epub 2018 May 22.

Institute of Cellular Medicine, Newcastle University, M2060 Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

Background: Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here.

Methods: A retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for bronchiectasis at the Freeman Hospital between 1990 and 2013. Read More

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The first case of multiple pulmonary granulomas with amyloid deposition in a dental technician; a rare manifestation as an occupational lung disease.

BMC Pulm Med 2018 May 22;18(1):77. Epub 2018 May 22.

Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryou-machi, Aoba-ku, Sendai, 980-8574, Japan.

Background: Occupational lung diseases, such as pneumoconiosis, are one of the health problems of dental workers that have been receiving increasing interest. Pulmonary amyloidosis is a heterogenous group of diseases, and can be classified into primary (idiopathic) and secondary (associated with various inflammatory diseases, hereditary, or neoplastic). To date, the development of pulmonary amyloidosis in dental workers has not been reported. Read More

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Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis.

BMC Pulm Med 2018 May 22;18(1):79. Epub 2018 May 22.

Department of Pediatrics I, University of Tübingen, Tübingen, Germany.

Bronchiectasis is a common feature of severe inherited and acquired pulmonary disease conditions. Among inherited diseases, cystic fibrosis (CF) is the major disorder associated with bronchiectasis, while acquired conditions frequently featuring bronchiectasis include post-infective bronchiectasis and chronic obstructive pulmonary disease (COPD). Mechanistically, bronchiectasis is driven by a complex interplay of inflammation and infection with neutrophilic inflammation playing a predominant role. Read More

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May 2018
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"The missing ingredient": the patient perspective of health related quality of life in bronchiectasis: a qualitative study.

BMC Pulm Med 2018 May 22;18(1):81. Epub 2018 May 22.

Division of Molecular and Clinical Medicine, University of Dundee, Dundee, DD1 9SY, UK.

Background: Bronchiectasis is a heterogeneous disease which affects quality of life. Measuring symptoms and quality of life has proved challenging and research is limited by extrapolation of questionnaires and treatments from other diseases. The objective of this study was to identify the major contributors to quality of life in bronchiectasis and to evaluate existing health related quality of life questionnaires in bronchiectasis. Read More

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May 2018
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Viruses in bronchiectasis: a pilot study to explore the presence of community acquired respiratory viruses in stable patients and during acute exacerbations.

BMC Pulm Med 2018 May 22;18(1):84. Epub 2018 May 22.

Department of Respiratory Medicine, Concord Repatriation General Hospital, Concord, NSW, 2139, Australia.

Background: Bronchiectasis is a chronic respiratory condition. Persistent bacterial colonisation in the stable state with increased and sometimes altered bacterial burden during exacerbations are accepted as key features in the pathophysiology. The extent to which respiratory viruses are present during stable periods and in exacerbations is less well understood. Read More

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May 2018
1 Read

Patient information, education and self-management in bronchiectasis: facilitating improvements to optimise health outcomes.

BMC Pulm Med 2018 May 22;18(1):80. Epub 2018 May 22.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Background: Bronchiectasis is an incurable lung disease characterised by irreversible airway dilatation. It causes symptoms including chronic productive cough, dyspnoea, and recurrent respiratory infections often requiring hospital admission. Fatigue and reductions in quality of life are also reported in bronchiectasis. Read More

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Bronchiectasis: an emerging global epidemic.

BMC Pulm Med 2018 May 22;18(1):76. Epub 2018 May 22.

Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital and Medical School, Dundee, UK.

Bronchiectasis has an increasing profile within respiratory medicine. This chronic and irreversible airways disease is common but suffers from a lack of evidenced based therapy for patients and, a lack of understanding of its inherent heterogeneity. Research focused on bronchiectasis must therefore be prioritized if we are to adequately address this evolving clinical problem. Read More

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Profiling non-tuberculous mycobacteria in an Asian setting: characteristics and clinical outcomes of hospitalized patients in Singapore.

BMC Pulm Med 2018 May 22;18(1):85. Epub 2018 May 22.

Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

Background: Non-tuberculous mycobacteria (NTM) infection is an increasing problem worldwide. The epidemiology of NTM in most Asian countries is unknown. This study investigated the epidemiology, and clinical profile of inpatients in whom NTM was isolated from various anatomical sites in a Singaporean population attending a major tertiary referral centre. Read More

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May 2018
4 Reads

NonTuberculous Mycobacteria infection and lung transplantation in cystic fibrosis: a worldwide survey of clinical practice.

BMC Pulm Med 2018 May 22;18(1):86. Epub 2018 May 22.

Institute of Cellular Medicine, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

Background: In people with cystic fibrosis infection with NonTuberculous Mycobacteria is of increasing prevalence. Mycobacterium abscessus complex is of particular concern and has been associated with adverse clinical outcomes. Optimal treatment usually requires multiple antibiotics for over 12 months. Read More

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May 2018
2 Reads

Symptom prevalence of patients with fibrotic interstitial lung disease: a systematic literature review.

BMC Pulm Med 2018 May 22;18(1):78. Epub 2018 May 22.

Cicely Saunders Institute, Bessemer Rd, London, UK.

Background: Those affected by advanced fibrotic interstitial lung diseases have limited treatment options and in the terminal stages, the focus of care is on symptom management. However, quantitatively, little is known about symptom prevalence. We aimed to determine the prevalence of symptoms in Progressive Idiopathic Fibrotic Interstitial Lung Disease (PIF-ILD). Read More

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May 2018
2 Reads

The lung microbiome in children with HIV-bronchiectasis: a cross-sectional pilot study.

BMC Pulm Med 2018 May 22;18(1):87. Epub 2018 May 22.

Department of Paediatrics and Child Health, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Background: Data on the lung microbiome in HIV-infected children is limited. The current study sought to determine the lung microbiome in HIV-associated bronchiectasis and to assess its association with pulmonary exacerbations.

Methods: A cross-sectional pilot study of 22 children (68% male; mean age 10. Read More

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May 2018
1 Read

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis.

BMC Pulm Med 2018 May 22;18(1):83. Epub 2018 May 22.

Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, 11 Mandalay Road, Singapore, 308232, Singapore.

Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasis is age-related and there is some geographical variation in incidence, prevalence and clinical features. Most bronchiectasis is reported to be idiopathic however post-infectious aetiologies dominate across Asia especially secondary to tuberculosis. Read More

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Occupational risk factors for idiopathic pulmonary fibrosis in Southern Europe: a case-control study.

BMC Pulm Med 2018 May 21;18(1):75. Epub 2018 May 21.

Section of Occupational Medicine, Respiratory Diseases and Toxicology, University of Perugia, Piazzale Gambuli, 06100, Perugia, Italy.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia of unknown cause associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Occupational risk factors have been proposed to be associated with UIP. The aim of this case-control study is to evaluate the relationship between UIP pattern and occupational exposure in Southern Europe. Read More

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May 2018
1 Read

Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD.

BMC Pulm Med 2018 May 21;18(1):74. Epub 2018 May 21.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: Findings describing the relationship between pulmonary function and peripheral vascular function have been inconclusive. We explored this relationship in Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD).

Methods: Brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were measured by a waveform analyser, and pulmonary function by turbine flowmeter spirometry. Read More

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Radiological pleuroparenchymal fibroelastosis associated to limited cutaneous systemic sclerosis: a case report.

BMC Pulm Med 2018 May 18;18(1):73. Epub 2018 May 18.

Internal Medicine Department, Hôpital Hôtel-Dieu, Centre Hospitalier Universitaire de Nantes, 1 place Alexis Ricordeau, 44093, Nantes, France.

Background: Pleuroparenchymal fibroelastosis (PPFE) is a very rare interstitial lung disease (ILD) characterized by progressive fibrotic lesions of the visceral pleura and the sub-pleural parenchyma, affecting predominantly the upper lobes. PPFE may occur in different contextes like bone marrow or lung transplantations, but also in the context of telomeropathy with mutations of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) or regulator of telomere elongation helicase 1 (RTEL1) genes. PPFE-like lesions have recently been described in patients with connective tissue disease (CTD)-related ILD. Read More

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May 2018
1 Read

Sleep-disordered breathing in patients with newly diagnosed lung cancer.

BMC Pulm Med 2018 May 16;18(1):72. Epub 2018 May 16.

Division of Pneumology, University Hospital RWTH Aachen, Aachen, Germany.

Background: There are currently no data on the prevalence of sleep-disordered breathing (SDB) in patients with newly-diagnosed lung cancer. This might be of interest given that SDB is associated with increased cancer incidence and mortality. Furthermore, intermittent hypoxia has been linked with tumor growth and progression. Read More

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May 2018
2 Reads

Management of acute respiratory failure in interstitial lung diseases: overview and clinical insights.

BMC Pulm Med 2018 May 15;18(1):70. Epub 2018 May 15.

Internsive Care Unit, Hospital Morales Meseguer, Múrcia, Spain.

Background: Interstitial lung diseases (ILDs) are a heterogeneous group of diseases characterized by widespread fibrotic and inflammatory abnormalities of the lung. Respiratory failure is a common complication in advanced stages or following acute worsening of the underlying disease. Aim of this review is to evaluate the current evidence in determining the best management of acute respiratory failure (ARF) in ILDs. Read More

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May 2018
1 Read

Telerehabilitation versus traditional centre-based pulmonary rehabilitation for people with chronic respiratory disease: protocol for a randomised controlled trial.

BMC Pulm Med 2018 May 15;18(1):71. Epub 2018 May 15.

Discipline of Physiotherapy, La Trobe University; Department of Physiotherapy, Alfred Health and Institute for Breathing and Sleep, La Trobe University, Melbourne, VIC, Australia.

Background: Pulmonary rehabilitation is an effective therapeutic intervention for people with chronic respiratory disease. However, fewer than 5% of eligible individuals receive pulmonary rehabilitation on an annual basis, largely due to limited availability of services and difficulties associated with travel and transport. The Rehabilitation Exercise At Home (REAcH) study is an assessor-blinded, multi-centre, randomised controlled equivalence trial designed to compare the efficacy of home-based telerehabilitation and traditional centre-based pulmonary rehabilitation in people with chronic respiratory disease. Read More

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May 2018
2 Reads

Prevalence of asthma among the adult general population of five Middle Eastern countries: results of the SNAPSHOT program.

BMC Pulm Med 2018 May 11;18(1):68. Epub 2018 May 11.

GlaxoSmithKline, PO Box 50199, Dubai, United Arab Emirates.

Background: Asthma is a common chronic respiratory disease leading to morbidity, mortality and impaired quality of life worldwide. Information on asthma prevalence in the Middle East is fragmented and relatively out-dated. The SNAPSHOT program was conducted to obtain updated information. Read More

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May 2018
2 Reads

Underlying and immediate causes of death in patients with idiopathic pulmonary fibrosis.

BMC Pulm Med 2018 May 11;18(1):69. Epub 2018 May 11.

Respiratory Medicine, Research Unit of Internal Medicine, University of Oulu and Medical Research Center Oulu, Oulu University Hospital, P.O. Box 20, 90029, Oulu, Finland.

Background: The most common cause of death of patients with idiopathic pulmonary fibrosis (IPF) has been reported to be the lung disease itself and mortality from IPF appears to be increasing. However, the causes of death in patients with IPF taking into account differences between genders and smoking histories as well as disease progression, have not been previously explored.

Methods: Retrospective data from hospital register and death certificates from national database of IPF patients treated in Kuopio University Hospital (KUH) from 2002 to 2012 were collected. Read More

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Higher serum 25-hydroxyvitamin D concentrations are associated with active pulmonary tuberculosis in hospitalised HIV infected patients in a low income tropical setting: a cross sectional study.

BMC Pulm Med 2018 May 8;18(1):67. Epub 2018 May 8.

Department of Chemical Pathology, University of Zimbabwe, College of Health Sciences, P.O. Box A178, Avondale, Harare, Zimbabwe.

Background: The inherent risk of developing tuberculosis (TB) in HIV- infected individuals is further enhanced by hypovitaminosis D. Interventions that offset HIV-associated immune deterioration potentially arrest disease progression and incidence of opportunistic infections including TB. Despite conflicting reports on association between vitamin D deficiency (VDD) and risk of TB, vitamin D (VD) supplementation remains a promising intervention. Read More

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May 2018
1 Read

Potential effect of household environment on prevalence of tuberculosis in India: evidence from the recent round of a cross-sectional survey.

BMC Pulm Med 2018 May 3;18(1):66. Epub 2018 May 3.

International Institute for Population Sciences, Govandi Station Road, Deonar Mumbai, 400088, India.

Background: Tuberculosis (TB) has been a major health problem globally since ages, and even today, it is a major cause of morbidity in millions of people each year. In 2015 alone, TB accounted for about 1.4 million deaths globally, with India carrying the biggest burden of the disease. Read More

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May 2018
2 Reads

Clinical utility of blood neutrophil-lymphocyte ratio in Japanese COPD patients.

BMC Pulm Med 2018 May 2;18(1):65. Epub 2018 May 2.

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of inflammation in chronic obstructive pulmonary disease (COPD) patients. But, a meaningful threshold and the longitudinal changes are unknown. We aimed to investigate the association between NLR and the clinical characteristics of COPD patients and to determine a meaningful threshold and the longitudinal changes for NLR. Read More

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May 2018
3 Reads

Delays to treatment initiation is associated with tuberculosis treatment outcomes among patients on directly observed treatment short course in Southwest Ethiopia: a follow-up study.

BMC Pulm Med 2018 May 2;18(1):64. Epub 2018 May 2.

Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Despite reported long delays to initiate anti-TB treatment and poor outcomes in different parts of Ethiopia and elsewhere, evidences on association between the delay and treatment outcomes are scanty.

Methods: A follow up study among 735 new TB cases registered at health facilities in districts of southwest Ethiopia was conducted from January 2015 to June 2016. Patients reported days elapsed between onset of illness and treatment commencement of 30 days cutoff was considered to ascertain exposure. Read More

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May 2018
2 Reads

Anti-fibrotic effects of pirfenidone and rapamycin in primary IPF fibroblasts and human alveolar epithelial cells.

BMC Pulm Med 2018 Apr 27;18(1):63. Epub 2018 Apr 27.

Department of Pneumology, Bellvitge University Hospital, Barcelona, Spain.

Background: Pirfenidone, a pleiotropic anti-fibrotic treatment, has been shown to slow down disease progression of idiopathic pulmonary fibrosis (IPF), a fatal and devastating lung disease. Rapamycin, an inhibitor of fibroblast proliferation could be a potential anti-fibrotic drug to improve the effects of pirfenidone.

Methods: Primary lung fibroblasts from IPF patients and human alveolar epithelial cells (A549) were treated in vitro with pirfenidone and rapamycin in the presence or absence of transforming growth factor β1 (TGF-β). Read More

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April 2018
1 Read

Improved heart hemodynamics after draining large-volume pleural effusion: a prospective cohort study.

BMC Pulm Med 2018 Apr 25;18(1):62. Epub 2018 Apr 25.

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Gongti Nanlu, Chaoyang District, Beijing, 100020, China.

Background: Pleural effusion (PE) drainage can relieve the symptoms of dyspnea; however, details of the resulting hemodynamic changes remain undefined.

Methods: Subjects older than 12 years with massive PE requiring pleural drainage were included in this study. Hemodynamic parameters were collected using transthoracic echocardiography at pre-drainage, immediately post-drainage, and 24 h after drainage. Read More

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Factors associated with asthma control: MOSAR study (Multicenter Observational Study of Asthma in Rabat-Morocco).

BMC Pulm Med 2018 Apr 24;18(1):61. Epub 2018 Apr 24.

Research team of Pharmacoepidemiology & Pharmacoeconomics, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Background: The purpose of the study is to describe the profile of patients with asthma and to identify the signifiant risks and the protective factors associated with asthma control.

Methods: A prospective epidemiological study was conducted in three hospitals of Rabat-Morocco and included 396 patients with asthma. Differences in characteristics across the levels of asthma control were compared by the one-way analysis of variance for continuous variables, and chi-square test was used for categorical variables. Read More

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April 2018
2 Reads

Is daily physical activity affected by dynamic hyperinflation in adults with cystic fibrosis?

BMC Pulm Med 2018 Apr 19;18(1):60. Epub 2018 Apr 19.

Department of Public Health and Infectious Diseases, Adult Cystic Fibrosis Center, Sapienza University of Rome, 00185, Rome, Italy.

Background: The aim of this study was to investigate the relationship between dynamic hyperinflation and daily physical activity (DPA) in adults with cystic fibrosis (CF).

Methods: Thirty-four clinically stable CF were studied. All patients undertook incremental cardiopulmonary exercise testing (CPET). Read More

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April 2018
2 Reads

MDA-5 associated rapidly progressive interstitial lung disease with recurrent Pneumothoraces: a case report.

BMC Pulm Med 2018 Apr 17;18(1):59. Epub 2018 Apr 17.

Rheumatology Department, Cork University Hospital, Wilton, Cork, Ireland.

Background: Clinically hypomyopathic dermatomyositis is a rare disease that is important to recognize, investigate and treat early as it is associated with poor prognosis. In a proportion of patients, myositis specific antibodies could be negative, but with high clinical suspicion, myositis associated antibodies should be ordered. Anti-MDA-5 antibodies was reported in literature to be associated with severe and rapidly progressive interstitial lung disease, with few case reports of pneumothorax and/or pneumomediastinum. Read More

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April 2018
2 Reads

Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma.

BMC Pulm Med 2018 Apr 10;18(1):58. Epub 2018 Apr 10.

University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.

Background: Although pre-puberty asthma is more prevalent in males, after puberty through middle-age, asthma is more prevalent in females. The surge of sex hormones with puberty might explain this gender switch.

Methods: To examine the effects of sex hormones on lung function and symptoms with puberty, Tanner stage was assessed in 187 children 6-18 years of age (59% severe) enrolled in the NIH/NHLBI Severe Asthma Research Program (SARP). Read More

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April 2018
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Comparative bench study evaluation of different infant interfaces for non-invasive ventilation.

BMC Pulm Med 2018 Apr 7;18(1):57. Epub 2018 Apr 7.

Intensive Care and Anaesthesia Department and Ventilab, Catholic University of Rome, Policlinico A. Gemelli, Largo Agostino Gemelli 8, 00168, Rome, Italy.

Background: To compare, in terms of patient-ventilator interaction and performance, a new nasal mask (Respireo, AirLiquide, FR) with the Endotracheal tube (ET) and a commonly used nasal mask (FPM, Fisher and Paykel, NZ) for delivering Pressure Support Ventilation (PSV) in an infant model of Acute Respiratory Failure (ARF).

Methods: An active test lung (ASL 5000) connected to an infant mannequin through 3 different interfaces (Respireo, ET and FPM), was ventilated with a standard ICU ventilator set in PSV. The test lung was set to simulate a 5. Read More

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April 2018
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Aspergillus fumigatus during COPD exacerbation: a pair-matched retrospective study.

BMC Pulm Med 2018 Apr 3;18(1):55. Epub 2018 Apr 3.

Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, 100730, People's Republic of China.

Background: Recently awareness of the importance of Aspergillus colonization in the airway of patients with chronic obstructive pulmonary disease (COPD) was rising. The aim of this study was to investigate the clinical features and short-term outcomes of COPD patients with Aspergillus colonization during acute exacerbation.

Methods: A pair-matched retrospective study on patients presenting with COPD exacerbation was conducted from January 2014 to March 2016 in Beijing Hospital, China. Read More

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April 2018
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