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    1 OF 61

    Medication adherence in patients with schizophrenia: a qualitative study of the patient process in motivational interviewing.
    BMC Psychiatry 2018 May 18;18(1):135. Epub 2018 May 18.
    Inholland University of Applied Sciences, De Boelelaan 1109, 1081 HV, Amsterdam, The Netherlands.
    Background: Motivational interviewing (MI) may be an effective intervention to improve medication adherence in patients with schizophrenia. However, for this patient group, mixed results have been found in randomized controlled trials. Furthermore, the process of becoming (more) motivated for long-term medication adherence in patients with schizophrenia is largely unexplored. Read More

    Policy development and challenges of global mental health: a systematic review of published studies of national-level mental health policies.
    BMC Psychiatry 2018 May 18;18(1):138. Epub 2018 May 18.
    Department of Social Medicine and Health Management, School of Public Health, Central South University, Changsha, China.
    Background: Mental health policy can be an essential and powerful tool to improve a population's mental health. However, around one third of countries do not possess a mental health policy, and there are large disparities in population coverage rates between high- and low-income countries. The goal of this study is to identify the transition and implementation challenges of mental health policies in both high-income countries (HICs) as well as middle- and low-income countries (MLICs). Read More

    Can deep transcranial magnetic stimulation (DTMS) be used to treat substance use disorders (SUD)? A systematic review.
    BMC Psychiatry 2018 May 18;18(1):137. Epub 2018 May 18.
    University of Limerick, Limerick, Ireland.
    Background: Deep transcranial magnetic stimulation (DTMS) is a non-invasive method of stimulating widespread cortical areas and, presumably, deeper neural networks. The current study assessed the effects of DTMS in the treatment of substance use disorders (SUD) using a systematic review.

    Methods: Electronic literature search (PsycInfo, Medline until April 2017) identified k = 9 studies (k = 4 randomized-controlled trials, RCTs, with inactive sham and k = 5 open-label studies). Read More

    Sleep disturbance and psychological distress are associated with functional dyspepsia based on Rome III criteria.
    BMC Psychiatry 2018 May 18;18(1):133. Epub 2018 May 18.
    Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
    Background: Functional dyspepsia (FD) is considered a bio-psychosocial disorder. The role of psychosocial factors in FD pathogenesis remains unclear.

    Methods: This study evaluated sleep quality and mood symptoms in patients with FD, assessing the associations of FD severity, disordered sleep, and psychological symptoms. Read More

    Depression and its psychosocial risk factors in pregnant Kenyan adolescents: a cross-sectional study in a community health Centre of Nairobi.
    BMC Psychiatry 2018 May 18;18(1):136. Epub 2018 May 18.
    Department of Psychiatry, College of Health Sciences, University of Nairobi, Nairobi, 00100 (47074), Kenya.
    Background: Adolescent pregnancies within urban resource-deprived settlements predispose young girls to adverse mental health and psychosocial adversities, notably depression. Depression in sub-Saharan Africa is a leading contributor to years lived with disability (YLD). The study's objective was to determine the prevalence of depression and related psychosocial risks among pregnant adolescents reporting at a maternal and child health clinic in Nairobi, Kenya. Read More

    Randomised Controlled Trial (RCT) of cannabinoid replacement therapy (Nabiximols) for the management of treatment-resistant cannabis dependent patients: a study protocol.
    BMC Psychiatry 2018 May 18;18(1):140. Epub 2018 May 18.
    Discipline of Addiction Medicine, Central Clinical School, University of Sydney, Sydney, NSW, Australia.
    Background: The cannabis extract nabiximols (Sativex®) effectively supresses withdrawal symptoms and cravings in treatment resistant cannabis dependent individuals, who have high relapse rates following conventional withdrawal treatments. This study examines the efficacy, safety and cost-effectiveness of longer-term nabiximols treatment for outpatient cannabis dependent patients who have not responded to previous conventional treatment approaches.

    Methods/design: A phase III multi-site outpatient, randomised, double-blinded, placebo controlled parallel design, comparing a 12-week course of nabiximols to placebo, with follow up at 24 weeks after enrolment. Read More

    The influence of cross-sectoral treatment models on patients with mental disorders in Germany: study protocol of a nationwide long-term evaluation study (EVA64).
    BMC Psychiatry 2018 May 18;18(1):139. Epub 2018 May 18.
    Center of Evidence-based Health Care, Medizinische Fakultät Carl Gustav Carus, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
    Background: Close, continuous and efficient collaboration between different professions and sectors of care is necessary to provide patient-centered care for individuals with mental disorders. The lack of structured collaboration between in- and outpatient care constitutes a limitation of the German health care system. Since 2012, a new law in Germany (§64b Social code book (SGB) V) has enabled the establishment of cross-sectoral and patient-centered treatment models in psychiatry. Read More

    Risk behavior in patients with severe mental disorders: a prospective study of 121,830 patients managed in rural households of western China.
    BMC Psychiatry 2018 May 18;18(1):134. Epub 2018 May 18.
    Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Background: The management of severe mental disorder (SMD) patients in communities is an important initiative of healthcare reform in China. Yet the effects in terms of risk behavior of patients are unclear, particularly in rural areas. This study aims to examine high risk behaviors, changing trends, and possible associated factors among SMD patients in the rural areas of western China. Read More

    Anxiety and depression in primary Sjögren's syndrome: a cross-sectional study.
    BMC Psychiatry 2018 May 16;18(1):131. Epub 2018 May 16.
    Department of Rheumatology, Affliated Hospital of Nantong University, 20th Xisi road, 226001, Nantong, People's Republic of China.
    Background: Prevalence of anxiety and depression is high in people with Primary Sjögren's syndrome (pSS). However, there are currently no known reported studies about anxiety/depression in pSS patients from China. Our aim was to compare anxiety/depression in pSS patients and healthy controls; to investigate the prevalence of anxiety and/or depression among pSS patients in China; to evaluate its relationship with the disease activity, fatigue, pain, education, ocular surface disease, oral health, swallowing disorders, employment status, European League Against Rheumatism Sjögren's Syndrome Patient Reported Index(ESSPRI) as well as to analyze potential determinants of anxiety and depression. Read More

    Prevalence, patterns and predictors of depression treatment among community-dwelling older adults with stroke in the United States: a cross sectional study.
    BMC Psychiatry 2018 May 16;18(1):130. Epub 2018 May 16.
    Department of Pharmacy Practice and Science, College of Pharmacy, The University of Arizona, 1295 North Martin Avenue, Tucson, AZ, 85721, USA.
    Background: Depression is one of the most common psychiatric conditions among stroke survivors and is associated with several negative health outcomes. However, little is known about the depression treatment patterns among stroke survivors. The objective of this study was to examine national-level prevalence, patterns and predictors of depression treatment among community-dwelling stroke survivors. Read More

    Mental health supported accommodation services: a systematic review of mental health and psychosocial outcomes.
    BMC Psychiatry 2018 May 15;18(1):128. Epub 2018 May 15.
    Division of Psychiatry, Faculty of Brain Sciences, UCL, 6th Floor, Maple House, 149 Tottenham Court Road, London, W1T 7NF, UK.
    Background: Post-deinstitutionalisation, mental health supported accommodation services have been implemented widely. The available research evidence is heterogeneous in nature and resistant to synthesis attempts, leaving researchers and policy makers with no clear summary what works and for whom. In this context, we undertook a comprehensive systematic review of quantitative studies in order to synthesise the current evidence on mental health and psychosocial outcomes for individuals residing in mental health supported accommodation services. Read More

    Functional connectivity of hippocampal subregions in PTSD: relations with symptoms.
    BMC Psychiatry 2018 May 15;18(1):129. Epub 2018 May 15.
    Department of Psychology, Ryerson University, 350 Victoria St, Toronto, ON, M5B 2K3, Canada.
    Background: Posttraumatic stress disorder (PTSD) is associated with abnormal hippocampal activity; however, the functional connectivity (FC) of the hippocampus with other brain regions in PTSD and its relations with symptoms warrants further attention. We investigated subregional hippocampal FC in PTSD during a resting state compared with a trauma-exposed control (TEC) group. Based on extant research, we targeted the FCs of the anterior and posterior hippocampal subregions with the amygdala, medial prefrontal cortex (mPFC), and the posterior cingulate (PCC). Read More

    Memory and potential correlates among children in Jordan.
    BMC Psychiatry 2018 May 11;18(1):127. Epub 2018 May 11.
    Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, 22110, Jordan.
    Background: Cognitive functioning hugely affects the performance of tasks of different complexity. Memory, one of the most important cognitive skills, allows children to practice and acquire necessary skills and knowledge and interact with the surrounding environment. Therefore, it is crucial to study the factors that influence the memory of children. Read More

    There is more to mental illness than negative affect: comprehensive temperament profiles in depression and generalized anxiety.
    BMC Psychiatry 2018 May 10;18(1):125. Epub 2018 May 10.
    Collective Intelligence Laboratory, Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Canada.
    Background: Temperament and mental illness are thought to represent varying degrees along the same continuum of neurotransmitter imbalances. A taxonomy of temperament could provide the basis for a new taxonomy of mental illness. Most popular models of temperament, being based heavily on emotionality traits, show very poor ability to discriminate between mental disorders. Read More

    Correction to: Dialectical behaviour therapy for treating adults and adolescents with emotional and behavioural dysregulation: study protocol of a coordinated implementation in a publicly funded health service.
    BMC Psychiatry 2018 May 7;18(1):123. Epub 2018 May 7.
    National Suicide Research Foundation, Western Gateway Building, University College Cork, Cork, Ireland.
    Upon publication of the original article (1) it was highlighted by the authors that there was just one error in the manuscript in the 'Sample size' subsection of the Methods/Design. Read More

    Understanding the ups and downs of living well: the voices of people experiencing early mental health recovery.
    BMC Psychiatry 2018 May 4;18(1):121. Epub 2018 May 4.
    WentWest, Blacktown, Australia.
    Background: The aim of this study was to better understand early-stage mental health recovery experiences of people living with severe and persistent mental illness and complex needs.

    Methods: Semi-structured, in-depth interviews were conducted with 13 people engaged in an Australian program specifically designed for people facing complex barriers to their recovery. Interview data were analysed thematically using constant comparative methods. Read More

    Predicting intentions to seek help for depression among undergraduates in Sri Lanka.
    BMC Psychiatry 2018 May 4;18(1):122. Epub 2018 May 4.
    Centre for Mental Health, Melbourne School of Population and Global Health, University of Melbourne, 207 Bouverie Street, Parkville, VIC, 3010, Australia.
    Background: Studies have found that although there are high rates of depression among university students, their help-seeking practices are poor. It is important to identify students who are less likely to seek the necessary help, to encourage better help-seeking among them. This study, which was conducted among undergraduates in Sri Lanka, examined the associations between personal characteristics of the undergraduates and their intentions to seek help for depression. Read More

    Evaluation of an electronic consultation service in psychiatry for primary care providers.
    BMC Psychiatry 2018 May 2;18(1):119. Epub 2018 May 2.
    Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
    Background: This study explores the effectiveness of an electronic consultation (eConsult) service between primary care providers and psychiatry, and the types and content of the clinical questions that were asked.

    Methods: This is a retrospective eConsult review study. All eConsults directed to Psychiatry from July 2011 to January 2015 by Primary care providers were reviewed. Read More

    Cost-effectiveness of the mobile application TCApp combined with face-to-face CBT treatment compared to face-to-face CBT treatment alone for patients with an eating disorder: study protocol of a multi-centre randomised controlled trial.
    BMC Psychiatry 2018 May 2;18(1):118. Epub 2018 May 2.
    Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu of Barcelona, Passeig Sant Joan de Déu, 2, 08950, Esplugues, Spain.
    Background: The clinical utility of the existing apps for people with eating disorders (EDs) is not clear. The TCApp has been specifically developed for people with EDs, is based on the principles of Cognitive Behavioural Treatment (CBT) and allows a bidirectional link between the patient and the therapist. The objectives of the study are, first, to assess the clinical efficacy of a combined intervention for Eating Disorders (EDs) that includes an online intervention through the TCApp plus standard face-to-face CBT in comparison to standard face-to-face CBT alone, and second, to examine the cost-effectiveness of the TCApp and identify potential predicting, moderating and mediating variables that promote or hinder the implementation of the TCApp in ED units in Spain. Read More

    How to integrate proxy data from two informants in life event assessment in psychological autopsy.
    BMC Psychiatry 2018 Apr 27;18(1):115. Epub 2018 Apr 27.
    Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, Zhejiang, China.
    Background: Life event assessment is an important part in psychological autopsy, and how to integrate its proxy data from two informants is a major methodological issue which needs solving.

    Methods: Totally 416 living subjects and their two informants were interviewed by psychological autopsy, and life events were assessed with Paykel's Interview for Recent Life Events. Validities of integrated proxy data using six psychological autopsy information reconstruction methods were evaluated, with living subjects' self-reports used as gold-standard criteria. Read More

    Associations between degree and sub-dimensions of depression and metabolic syndrome (MetS) in the community: results from the Gutenberg Health Study (GHS).
    BMC Psychiatry 2018 Apr 27;18(1):114. Epub 2018 Apr 27.
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
    Background: A growing number of studies have associated metabolic syndrome (MetS) and depression, both retrospectively and prospectively. However, it has remained unclear, which degrees, or sub-dimensions of depression are related to MetS and if comorbid depression affects health care utilization. The purpose of the study was to determine the associations of a) somatic and cognitive-affective symptoms to MetS and b) depression and MetS to health care utilization. Read More

    Collaborative, individualised lifestyle interventions are acceptable to people with first episode psychosis; a qualitative study.
    BMC Psychiatry 2018 Apr 25;18(1):111. Epub 2018 Apr 25.
    Division of Psychology and Mental Health, The University of Manchester, Manchester Academic Health Science Centre, Coupland 1 Building, Oxford Road, Manchester, M13 9PL, UK.
    Background: The adverse impact of unhealthy lifestyle choices and the prescription of antipsychotic medications contribute to weight gain, poor cardiovascular health and reduced life expectancy for people with psychosis. The present study aimed to explore the acceptability and perceived outcomes of a lifestyle intervention designed to prevent or reduce weight gain in people with first-episode psychosis.

    Methods: This was a qualitative study using a data-driven approach. Read More

    Psychometric properties and measurement invariance of the Beck hopelessness scale (BHS): results from a German representative population sample.
    BMC Psychiatry 2018 Apr 25;18(1):110. Epub 2018 Apr 25.
    Department of Psychosomatic Medicine and Psychotherapy, University of Mainz, |Untere Zahlbacher Str. 8, 55131, Mainz, Germany.
    Background: The Beck Hopelessness Scale (BHS) has been the most frequently used instrument for the measurement of hopelessness in the past 40 years. Only recently has it officially been translated into German. The psychometric properties and factor structure of the BHS have been cause for intensive debate in the past. Read More

    Distributional patterns of item responses and total scores on the PHQ-9 in the general population: data from the National Health and Nutrition Examination Survey.
    BMC Psychiatry 2018 Apr 23;18(1):108. Epub 2018 Apr 23.
    Department of Health Promotion and Human Behavior, Department of Clinical Epidemiology, Kyoto University Graduate School of Medicine/School of Public Health, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
    Background: Recently, item responses and total scores on depression screening scales have been reported to have characteristic distributions in the general population. The distributional pattern of responses to the Patient Health Questionnaire-9 (PHQ-9) in the general population has not been well studied. Thus, we carried out a pattern analysis of the PHQ-9 item responses and total scores in US adults. Read More

    The German version of the helping alliance questionnaire: psychometric properties in patients with persistent depressive disorder.
    BMC Psychiatry 2018 Apr 23;18(1):107. Epub 2018 Apr 23.
    Central Institute of Mental Health, Department of Clinical Psychology, Medical Faculty Mannheim/Heidelberg University, J5, 68159 Mannheim, Heidelberg, Germany.
    Background: The Helping Alliance Questionnaire (HAQ) is a frequently used and highly relevant instrument to assess the therapeutic alliance. The questionnaire was translated into German by Bassler and colleagues (1995) and is available for patients (HAQ-P) and therapists (HAQ-T). Whereas the HAQ-P has been tested regarding psychometrics, the HAQ-T has not. Read More

    Validation of the posttraumatic stress disorder checklist - 5 (PCL-5) in a primary care population with high HIV prevalence in Zimbabwe.
    BMC Psychiatry 2018 Apr 23;18(1):109. Epub 2018 Apr 23.
    College of Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
    Background: There is a dearth of validated tools measuring posttraumatic stress disorder (PTSD) in low and middle-income countries in sub-Saharan Africa. We validated the Shona version of the PTSD Checklist for DSM-5 (PCL-5) in a primary health care clinic in Harare, Zimbabwe.

    Method: Adults aged 18 and above attending the clinic were enrolled over a two-week period in June 2016. Read More

    Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science.
    BMC Psychiatry 2018 Apr 18;18(1):106. Epub 2018 Apr 18.
    National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India.
    Background: There is emerging evidence that there are shared genetic, environmental and developmental risk factors in psychiatry, that cut across traditional diagnostic boundaries. With this background, the Discovery biology of neuropsychiatric syndromes (DBNS) proposes to recruit patients from five different syndromes (schizophrenia, bipolar disorder, obsessive compulsive disorder, Alzheimer's dementia and substance use disorders), identify those with multiple affected relatives, and invite these families to participate in this study. The families will be assessed: 1) To compare neuro-endophenotype measures between patients, first degree relatives (FDR) and healthy controls. Read More

    Assessment of subjective emotional valence and long-lasting impact of life events: development and psychometrics of the Stralsund Life Event List (SEL).
    BMC Psychiatry 2018 Apr 18;18(1):105. Epub 2018 Apr 18.
    Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Ellernholzstraße 1-2, 17489, Greifswald, Germany.
    Background: Life events (LEs) are associated with future physical and mental health. They are crucial for understanding the pathways to mental disorders as well as the interactions with biological parameters. However, deeper insight is needed into the complex interplay between the type of LE, its subjective evaluation and accompanying factors such as social support. Read More

    Characterizing the experience of agitation in patients with bipolar disorder and schizophrenia.
    BMC Psychiatry 2018 Apr 16;18(1):104. Epub 2018 Apr 16.
    Adelphi Real World, Macclesfield, UK.
    Background: Agitation is a common manifestation of bipolar disorder and schizophrenia which includes symptoms ranging from inner tension and unease to violence and aggression. Much of the existing literature has focused on agitation in the acute setting, with the patient experience poorly defined. Thus, the aim of this study was to characterize agitation and its management from a patient perspective, with the focus on those who reside in the community. Read More

    Efficacy of shared decision-making on treatment adherence of patients with bipolar disorder: a cluster randomized trial (ShareD-BD).
    BMC Psychiatry 2018 Apr 13;18(1):103. Epub 2018 Apr 13.
    CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, EA7280, Clermont-Ferrand, France.
    Background: Shared decision-making (SDM) is a model of interaction between doctors and patients in which both actors contribute to the medical decision-making process. SDM has raised great interest in mental healthcare over the last decade, as it is considered a fundamental part of patient-centered care. However, there is no research evaluating the efficacy of SDM compared to usual care (CAU), as it relates to quality of care and more specifically treatment adherence, in bipolar disorder (BD). Read More

    An internet-based intervention for people with psychosis (EviBaS): study protocol for a randomized controlled trial.
    BMC Psychiatry 2018 Apr 13;18(1):102. Epub 2018 Apr 13.
    Department of Clinical Psychology and Psychotherapy, University of Bern, Fabrikstrasse 8, 3012, Bern, Switzerland.
    Background: Evidence shows that internet-based self-help interventions are effective in reducing symptoms for a wide range of mental disorders. To date, online interventions treating psychotic disorders have been scarce, even though psychosis is among the most burdensome disorders worldwide. Furthermore, the implementation of cognitive-behavioral therapy (CBT) for psychosis in routine health care is challenging. Read More

    A video-based transdiagnostic REBT universal prevention program for internalizing problems in adolescents: study protocol of a cluster randomized controlled trial.
    BMC Psychiatry 2018 Apr 13;18(1):101. Epub 2018 Apr 13.
    Department of Clinical Psychology and Psychotherapy, Babeș-Bolyai University, Republicii St., No. 37, 400015, Cluj-Napoca, Romania.
    Background: Internalizing problems are the most prevalent mental health problems in adolescents. Transdiagnostic programs are promising manners to treat multiple problems within the same protocol, however, there is limited research regarding the efficacy of such programs delivered as universal prevention programs in school settings. Therefore, the present study aims to investigate the efficacy of a video-based transdiagnostic rational emotive behavioral therapy (REBT) universal prevention program, for internalizing problems. Read More

    Standardisation framework for the Maudsley staging method for treatment resistance in depression.
    BMC Psychiatry 2018 Apr 11;18(1):100. Epub 2018 Apr 11.
    King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, Centre for Affective Disorders, London, UK.
    Background: Treatment-resistant depression (TRD) is a serious and relatively common clinical condition. Lack of consensus on defining and staging TRD remains one of the main barriers to understanding TRD and approaches to intervention. The Maudsley Staging Method (MSM) is the first multidimensional model developed to define and stage treatment-resistance in "unipolar depression". Read More

    Using photo-elicitation to understand reasons for repeated self-harm: a qualitative study.
    BMC Psychiatry 2018 Apr 11;18(1):98. Epub 2018 Apr 11.
    Institute of Health Sciences, School of Medicine, University of Leeds, 101 Clarendon Rd, Leeds, LS2 9LJ, UK.
    Background: Reasons for self-harm are not well understood. One of the reasons for this is that first-hand accounts are usually elicited using traditional interview and questionnaire methods. This study aims to explore the acceptability of using an approach (photo-elicitation) that does not rely on solely verbal or written techniques, and to make a preliminary assessment of whether people can usefully employ images to support a discussion about the reasons why they self-harm. Read More

    Shared facial emotion processing functional network findings in medication-naïve major depressive disorder and healthy individuals: detection by sICA.
    BMC Psychiatry 2018 Apr 10;18(1):96. Epub 2018 Apr 10.
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
    Background: The fundamental mechanism underlying emotional processing in major depressive disorder (MDD) remains unclear. To better understand the neural correlates of emotional processing in MDD, we investigated the role of multiple functional networks (FNs) during emotional stimuli processing.

    Methods: Thirty-two medication-naïve subjects with MDD and 36 healthy controls (HCs) underwent an emotional faces fMRI task that included neutral, happy and fearful expressions. Read More

    Machine learning classification of first-episode schizophrenia spectrum disorders and controls using whole brain white matter fractional anisotropy.
    BMC Psychiatry 2018 Apr 10;18(1):97. Epub 2018 Apr 10.
    National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic.
    Background: Early diagnosis of schizophrenia could improve the outcome of the illness. Unlike classical between-group comparisons, machine learning can identify subtle disease patterns on a single subject level, which could help realize the potential of MRI in establishing a psychiatric diagnosis. Machine learning has previously been predominantly tested on gray-matter structural or functional MRI data. Read More

    Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study.
    BMC Psychiatry 2018 Apr 10;18(1):94. Epub 2018 Apr 10.
    Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
    Background: Major depressive disorder (MDD) is a mixed disorder with the highly irregular course, inconsistent response to treatment and has no well-known mechanism for the pathophysiology. Major causes of depression are genetic, neurobiological, and environmental. However, over the past few years, altered serum levels of macro-minerals (MM) and trace elements (TE) have been recognized as major causative factors to the pathogenesis of many mental disorders. Read More

    Prospective, randomized, double-blind, placebo-controlled phase IIa clinical trial on the effects of an estrogen-progestin combination as add-on to inpatient psychotherapy in adult female patients suffering from anorexia nervosa.
    BMC Psychiatry 2018 Apr 10;18(1):93. Epub 2018 Apr 10.
    Department of Psychosomatic Medicine and Psychotherapy, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany.
    Background: There is a need for novel treatment approaches in anorexia nervosa (AN). While there is broad knowledge with regard to altered appetite regulation and neuropsychological deficits in AN patients on the one hand, and the effects of estrogen replacement upon neuropsychological performance in healthy subjects on the other, up to now, no study has implemented estrogen replacement in AN patients, in order to examine its effects upon AN-associated and general psychopathology, neuropsychological performance and concentrations of peptide components of the hypothalamus-pituitary-adrenal (HPA) axis and within appetite-regulating circuits.

    Methods: This is a randomized placebo-controlled clinical trial on the effects of a 10-week oral estrogen replacement (combination of ethinyl estradiol 0. Read More

    Trauma exposure and the mediating role of posttraumatic stress on somatic symptoms in civilian war victims.
    BMC Psychiatry 2018 Apr 10;18(1):92. Epub 2018 Apr 10.
    Division of Clinical and Health Psychology, Department of Psychology, University of Fribourg, 1700, Fribourg, Switzerland.
    Background: It has been well documented that the exposure to war has a negative effect on the psychological health of civilian. However, little is known on the impact of war exposure on the physical health of the civilian population. In addition, the link between trauma exposure and somatic symptoms remain poorly understood. Read More

    The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment.
    BMC Psychiatry 2018 Apr 10;18(1):95. Epub 2018 Apr 10.
    Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Post Box 104, Ottestad, N-2381, Brumunddal, Norway.
    Background: Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol into account. Read More

    Psychometric properties of the Arabic version of the confusion assessment method for the intensive care unit (CAM-ICU).
    BMC Psychiatry 2018 Apr 6;18(1):91. Epub 2018 Apr 6.
    King Abdullah International Medical Research Center, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
    Background: It is recommended that critically ill patients undergo routine delirium monitoring with a valid and reliable tool such as the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). However, the validity and reliability of the Arabic version of the CAM-ICU has not been investigated. Here, we test the validity and reliability of the Arabic CAM-ICU. Read More

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