Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking tissue-type plasminogen activator.
- Jessica A Krizo,
- Linley E Moreland,
- Ashutosh Rastogi,
- Xiang Mou,
- Rebecca A Prosser,
- Eric M Mintz
BMC Physiol 2018 Jan 25;18(1). Epub 2018 Jan 25.
Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA.
Background: Circadian rhythms of physiology and behavior are driven by a circadian clock located in the suprachiasmatic nucleus of the hypothalamus. This clock is synchronized to environmental day/night cycles by photic input, which is dependent on the presence of mature brain-derived neurotrophic factor (BDNF) in the SCN. Mature BDNF is produced by the enzyme plasmin, which is converted from plasminogen by the enzyme tissue-type plasminogen activator (tPA). Read More