156,690 results match your criteria BMC Pharmacology [Journal]


Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar.

BMC Res Notes 2018 Dec 14;11(1):898. Epub 2018 Dec 14.

Unité d'Immunologie, Institut Pasteur de Madagascar, Ambatofotsikely, P.O. Box 1274, Antananarivo, Madagascar.

Objectives: In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. Read More

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December 2018

Clinical, immunological and bacteriological characteristics of H7N9 patients nosocomially co-infected by Acinetobacter Baumannii: a case control study.

BMC Infect Dis 2018 Dec 14;18(1):664. Epub 2018 Dec 14.

Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, 518112, China.

Background: Bacterial co-infection of patients suffering from influenza pneumonia is a key element that increases morbidity and mortality. The occurrence of Acinetobacter baumannii co-infection in patients with avian influenza A (H7N9) virus infection has been described as one of the most prevalent bacterial co-infections. However, the clinical and laboratory features of this entity of H7N9 and A. Read More

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December 2018

Correction to: Effectiveness of aripiprazole once-monthly in schizophrenia patients pretreated with oral aripiprazole: a 6-month, real-life non-interventional study.

BMC Psychiatry 2018 Dec 14;18(1):389. Epub 2018 Dec 14.

Klinik für Psychiatrie und Psychotherapie, Zentrum für Psychosoziale, Medizin, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20, ,246, Hamburg, Germany.

Following publication of the original article. Read More

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December 2018

Inventory of oncologists' unmet needs for tools to support decision-making about palliative treatment for metastatic colorectal cancer.

BMC Med Inform Decis Mak 2018 Dec 14;18(1):132. Epub 2018 Dec 14.

Department of Epidemiology and Biostatistics, Amsterdam UMC, location VUMC, F-wing Medical Faculty building, PO Box 7057 1007, MB, Amsterdam, The Netherlands.

Background: Decision-making about palliative care for metastatic colorectal cancer (mCRC) consists of many different treatment-related decisions, and there generally is no best treatment option. Decision support systems (DSS), e.g. Read More

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December 2018

Current and ceased users of sit stand workstations: a qualitative evaluation of ergonomics, safety and health factors within a workplace setting.

BMC Public Health 2018 Dec 14;18(1):1374. Epub 2018 Dec 14.

Centre for Ergonomics and Human Factors, School of Psychology and Public Health, College of Science, Health and Engineering, Latrobe University, Melbourne, Australia.

Background: Many workplaces have implemented sit-stand workstations (SSW), which enable a worker to transition between sitting and standing as they perform their work activities. The factors which determine the initial adoption, sustainability or cessation of use for a SSW, remain largely unexamined. This study investigates the experiences of workers who had previously used or were currently using a SSW. Read More

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December 2018

Quantification and pharmacokinetic study of entrectinib in rat plasma using ultra-performance liquid chromatography tandem mass spectrometry.

Biomed Chromatogr 2018 Dec 13:e4467. Epub 2018 Dec 13.

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China.

To characterize the preclinical plasma pharmacokinetics of entrectinib, a reproducible and precise assay is necessary. In this study, we developed and validated a simple ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the measurement of entrectinib using carbamazepine as the internal standard (IS) in rat plasma. Sample preparation was a simple protein precipitation with acetonitrile, then entrectinib was eluted on an Acquity UPLC BEH C18 column (2. Read More

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December 2018

An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLC-QTOF-MS method.

Biomed Chromatogr 2018 Dec 13:e4469. Epub 2018 Dec 13.

Drug Metabolism and Interactions Research Lab, Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.

Green tea extracts (GTE) has been reported to be a kinase inhibitor and modulator for various drug metabolizing enzymes. It may give synergetic antioncogenic effect, but with a possibility of pharmacokinetic interactions with various co-administered anticancer agents like palbociclib (PAL), a selective inhibitor of CDK-4/6 primarily metabolized by CYP3A4 enzyme. To explore the impact of GTE on PAL pharmacokinetics in Sprague Dawley rats, a rapid and sensitive UHPLC-QTOF-MS method was established. Read More

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December 2018

Determination of Olanzapine for Therapeutic Drug Monitoring in Schizophrenia Patients by LC/MS Method.

Biomed Chromatogr 2018 Dec 13:e4468. Epub 2018 Dec 13.

Department of Psychiatry, İzmir Katip Çelebi University, Ataturk Training and Research Hospital, İzmir, Turkey.

Olanzapine is an atypical antipsychotic drug from thienobenzodiazepine family which displays efficacy in patients with schizophrenia and related psychoses. A novel LC/MS method was developed and validated for determination of olanzapine in schizophrenia patients plasma. A liquid-liquid extraction procedure carried out by using 5 mL diethyl ether-diisopropyl ether mixture (1:1, v/v). Read More

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December 2018

Stability and degradation products of imipenem applying High-Resolution Mass Spectrometry: an analytical study focused on solutions for infusion.

Biomed Chromatogr 2018 Dec 13:e4471. Epub 2018 Dec 13.

Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre-RS, Brazil.

Carbapenems show recognized instability in aqueous solutions, therefore some care must be taken from its handling and preparation to its use in the hospital environment. Here, the stability and degradation products of imipenem were investigated from conditions that simulate its clinical use. For this, a simple stability-indicating method by HPLC-DAD was validated with focus on quantitation of drug concentration remaining from infusion solutions (sodium chloride 0. Read More

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December 2018

A quantitative LC-MS/MS method for determination of a small molecule agonist of EphA2 in mouse plasma and brain tissue.

Biomed Chromatogr 2018 Dec 12:e4461. Epub 2018 Dec 12.

Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Compound 27 [1, 12-bis(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)dodecane-1,12-dione ] is a novel small molecule agonist of EphA2 receptor Tyrosine Kinase. It showed much improved activity for the activation of EphA2 receptor compared to the parental compound Doxazosin. To support further pharmacological and toxicological studies of the compound, a method using liquid chromatography and electrospray ionization tandem mass spectrometry (LC- MS/MS) has been developed for the quantification of this compound. Read More

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December 2018

Analysis of carbenoxolone by ultra-performance liquid chromatography tandem mass spectrometry in mouse brain and blood after systemic administration.

Biomed Chromatogr 2018 Dec 11:e4465. Epub 2018 Dec 11.

Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA, USA.

Carbenoxolone is a derivative of glycyrrhetinic acid found in the root of Glycyrrhiza glabra, colloquially known as licorice. It has been used as a treatment for peptic and oral ulcers. In recent years, carbenoxolone has been utilized in basic research for its ability to block gap junctional communication. Read More

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December 2018

Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT-QuIC.

BMC Res Notes 2018 Dec 14;11(1):895. Epub 2018 Dec 14.

Virus and Prion Research Unit, National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, IA, 50010, USA.

Objective: Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the misfolding of the cellular prion protein (PrP) into a pathogenic form (PrP) that accumulates in the brain and lymphatic tissue. Amplification based assays such as real-time quaking induced conversion allow us to assess the conversion of PrP to PrP. Read More

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December 2018

Determinants of burnout syndrome among nurses in Cameroon.

BMC Res Notes 2018 Dec 14;11(1):893. Epub 2018 Dec 14.

Health and Human (2HD) Research Network, Douala, Cameroon.

Objectives: Burnout syndrome is common amongst medical personnel. The objective of this study was to identify determinants of burnout syndrome among nurses in the north west and south west regions of Cameroon.

Results: A cross-sectional analysis during the months of January-June 2018 was carried out recruiting nurses consecutively after consent from state-owned and private hospitals in the English-speaking regions of Cameroon. Read More

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December 2018

A neural network analysis of Lifeways cross-generation imputed data.

BMC Res Notes 2018 Dec 14;11(1):897. Epub 2018 Dec 14.

School of Mathematics and Statistics, University College Dublin, Belfield, Dublin 4, Dublin, Ireland.

Objectives: Neural networks are a powerful statistical tool that use nonlinear regression type models to obtain predictions. Their use in the Lifeways cross-generation study that examined body mass index (BMI) of children, among other measures, is explored here. Our aim is to predict the BMI of children from that of their parents and maternal and paternal grandparents. Read More

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December 2018

Co-expression of long non-coding RNAs and autism risk genes in the developing human brain.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):91. Epub 2018 Dec 14.

Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29646, USA.

Background: Autism Spectrum Disorder (ASD) is the umbrella term for a group of neurodevelopmental disorders convergent on behavioral phenotypes. While many genes have been implicated in the disorder, the predominant focus of previous research has been on protein coding genes. This leaves a vast number of long non-coding RNAs (lncRNAs) not characterized for their role in the disorder although lncRNAs have been shown to play important roles in development and are highly represented in the brain. Read More

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December 2018

A problem shared is a problem halved? Comparing burdens arising for family caregivers of patients with disorders of consciousness in institutionalized versus at home care.

BMC Psychol 2018 Dec 14;6(1):58. Epub 2018 Dec 14.

Department of Psychology, University of Bielefeld, Bielefeld, Germany.

Background: Disorders-of-consciousness (DOC) are rare conditions leading to very severe physical and mental disabilities. Providing care for DOC patients has been described as a stressful experience, eroding the physical and psychological health of the caregiver. Different forms of care may have different impacts on the caregivers and institutionalized care has been suggested to have an unburdening effect, but this possibility has never been empirically studied. Read More

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December 2018

Level of unintended pregnancy among reproductive age women in Bahir Dar city administration, Northwest Ethiopia.

BMC Res Notes 2018 Dec 14;11(1):891. Epub 2018 Dec 14.

Department of Reproductive Health, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Objective: The objective of this study was to determine the prevalence and determinants of unintended pregnancy among reproductive age women in Bahir Dar town, Northwest Ethiopia.

Result: The prevalence of unintended pregnancy was 15.8% (95% CI 13. Read More

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December 2018

Adherence to face-down and non-supine positioning after macular hole surgery.

BMC Ophthalmol 2018 Dec 14;18(1):322. Epub 2018 Dec 14.

Department of Ophthalmology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

Background: This study aimed to investigate patient adherence to face-down positioning (FDP) and non-supine positioning (NSP) following vitrectomy with gas tamponade for treating macular holes (MHs).

Methods: Nursing records of 92 patients who underwent vitrectomy with gas tamponade for small-diameter (diameter < 400 μm) MHs during April 2016-June 2017 were examined. Forty-seven and 45 patients were instructed to maintain FDP and NSP (FDP and NSP groups), respectively. Read More

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December 2018

Low dietary diversity and associated factors among lactating mothers in Angecha districts, Southern Ethiopia: community based cross-sectional study.

BMC Res Notes 2018 Dec 14;11(1):892. Epub 2018 Dec 14.

Department of Reproductive Health, Institute of Public Health, College of Medicine and Health Science, University of Gondar, 196, Gondar, Ethiopia.

Objective: The objective of the study was to assess prevalence low dietary diversity and associated factors among lactating mother in Angecha district, Southern Ethiopia.

Results: The magnitude of low dietary diversity was 52.2%, 95% confidence interval (47. Read More

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December 2018
2 Reads

Piloting of WHO Safe Childbirth Checklist using a modified version in Sri Lanka.

BMC Res Notes 2018 Dec 14;11(1):896. Epub 2018 Dec 14.

University Obstetrics Unit, De Soysa Hospital for Women, Colombo, Sri Lanka.

Objectives: Data was gathered to study the impact of a context-specific modified WHO Safe Childbirth Checklist (mSCC) at two tertiary care settings in Sri Lanka, as a part of an implementation program.

Data Description: We provide data sets of a prospective observational study which was conducted in the University Obstetrics Unit at De Soysa Hospital for Women (DSHW), Colombo and two Obstetric Units at Teaching Hospital, Mahamodara, Galle (THMG), Sri Lanka. These consist of demographic and checklist implementation details and data on the level of acceptance. Read More

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December 2018

Frequency and associated risk factors of non-fatal overdose reported by pregnant women with opioid use disorder.

Addict Sci Clin Pract 2018 Dec 14;13(1):26. Epub 2018 Dec 14.

Department of Pediatrics, Boston University School of Medicine, Boston Medical Center, Boston, MA, 02118, USA.

Background: Little is known about opioid overdose or naloxone access among pregnant women.

Objectives: The objectives of this study were to determine the prevalence of non-fatal overdose, risk factors for overdose, and naloxone access among third trimester women in treatment for opioid use disorder.

Methods: We collected baseline data from a case management parental-support intervention study. Read More

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December 2018

Effect of CFIm25 knockout on RNA polymerase II transcription.

BMC Res Notes 2018 Dec 14;11(1):894. Epub 2018 Dec 14.

Sir William Dunn School of Pathology, University of Oxford, South Park Roads, Oxford, OX1 3RE, UK.

Objectives: Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is a highly regulated process. Most human genes have multiple poly(A) sites, which define different possible mRNA ends, suggesting the existence of mechanisms that regulate which poly(A) site is used. Poly(A) site selection may be mediated by cleavage factor I (CFIm), which is part of the cleavage and polyadenylation (CPA) complex. Read More

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December 2018

Effectiveness and costs of non-invasive foetal RHD genotyping in rhesus-D negative mothers: a French multicentric two-arm study of 850 women.

BMC Pregnancy Childbirth 2018 Dec 14;18(1):496. Epub 2018 Dec 14.

AP-HP Health Economics Clinical Research Platform (URCEco), Hotel Dieu, Place de Parvis, 75004, Paris, France.

Background: The determination of foetal Rhesus D (RHD) status allows appropriate use of IgRh prophylaxis by restricting its use to cases of RHD feto-maternal incompatibilities. There is a degree of uncertainty about the cost-effectiveness of foetal RHD determination, yet screening programs are being introduced into clinical practice in many countries. This paper evaluates the impact of non-invasive foetal Rhesus D (RHD) status determination on the costs of managing RHD-negative pregnant women and on the appropriate use of anti-D prophylaxis in a large sample of RHD-negative pregnant women using individual prospectively collected clinical and economic data. Read More

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December 2018

Systems biology analysis reveals new insights into invasive lung cancer.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):117. Epub 2018 Dec 14.

MidSouth Bioinformatics Center and Joint Bioinformatics Ph.D. Program, University of Arkansas at Little Rock and University of Arkansas for Medical Sciences, 2801 S. University Avenue, Little Rock, AR, 72204, USA.

Background: Adenocarcinoma in situ (AIS) is a pre-invasive lesion in the lung and a subtype of lung adenocarcinoma. The patients with AIS can be cured by resecting the lesion completely. In contrast, the patients with invasive lung adenocarcinoma have very poor 5-year survival rate. Read More

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December 2018

A hotspots analysis-relation discovery representation model for revealing diabetes mellitus and obesity.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):116. Epub 2018 Dec 14.

Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun, 130012, China.

Background: Nowadays, because of the huge economic burden on society causing by obesity and diabetes, they turn into the most serious public health challenges in the world. To reveal the close and complex relationships between diabetes, obesity and other diseases, search the effective treatment for them, a novel model named as representative latent Dirichlet allocation (RLDA) topic model is presented.

Results: RLDA was applied to a corpus of more than 337,000 literatures of diabetes and obesity which were published from 2007 to 2016. Read More

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December 2018

Comparative toxicogenomics of three insensitive munitions constituents 2,4-dinitroanisole, nitroguanidine and nitrotriazolone in the soil nematode Caenorhabditis elegans.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):92. Epub 2018 Dec 14.

Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, MS, 39180, USA.

Background: Ecotoxicological studies on the insensitive munitions formulation IMX-101 and its components 2,4-dinitroanisole (DNAN), nitroguanidine (NQ) and nitrotriazolone (NTO) in various organisms showed that DNAN was the main contributor to the overall toxicity of IMX-101 and suggested that the three compounds acted independently. These results motivated this toxicogenomics study to discern toxicological mechanisms for these compounds at the molecular level.

Methods: Here we used the soil nematode Caenorhabditis elegans, a well-characterized genomics model, as the test organism and a species-specific, transcriptome-wide 44 K-oligo probe microarray for gene expression analysis. Read More

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December 2018

Using automated electronic medical record data extraction to model ALS survival and progression.

BMC Neurol 2018 Dec 14;18(1):205. Epub 2018 Dec 14.

Department of Neurology, University of Kansas Medical Center, Kansas City, USA.

Background: To assess the feasibility of using automated capture of Electronic Medical Record (EMR) data to build predictive models for amyotrophic lateral sclerosis (ALS) outcomes.

Methods: We used an Informatics for Integrating Biology and the Bedside search discovery tool to identify and extract data from 354 ALS patients from the University of Kansas Medical Center EMR. The completeness and integrity of the data extraction were verified by manual chart review. Read More

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December 2018

Evaluation of an educational intervention in oral health for primary care physicians: a cluster randomized controlled study.

BMC Oral Health 2018 Dec 14;18(1):218. Epub 2018 Dec 14.

Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, P.O. Box 7804, N-5020, Bergen, Norway.

Background: Family physicians are in frequent contact with patients, and their contribution to oral health promotion programs could be utilized more effectively. We implemented an oral health care (OHC) educational seminar for physicians and evaluated its impact on their knowledge retention in OHC.

Methods: We conducted an educational trial for primary care physicians (n = 106) working in Public Health Centers in Tehran city. Read More

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December 2018
1.147 Impact Factor

MISC: missing imputation for single-cell RNA sequencing data.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):114. Epub 2018 Dec 14.

Joint Bioinformatics Program, University of Arkansas Little Rock George Washington Donaghey College of Engineering & IT and University of Arkansas for Medical Sciences, Little Rock, AR, 72204, USA.

Background: Single-cell RNA sequencing (scRNA-seq) technology provides an effective way to study cell heterogeneity. However, due to the low capture efficiency and stochastic gene expression, scRNA-seq data often contains a high percentage of missing values. It has been showed that the missing rate can reach approximately 30% even after noise reduction. Read More

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December 2018

EMPATHIC-N in a Greek-Cypriot sample: confirming its factorial structure.

BMC Health Serv Res 2018 Dec 14;18(1):968. Epub 2018 Dec 14.

Health Management Unit, Open University of Cyprus, Nicosia, Cyprus.

Background: Family-centered care has been receiving increased attention during the last decades and health professionals recognize family satisfaction with care as an important health indicator. The Empowerment of Parents in The Intensive Care-Neonatology (EMPATHIC-N) is a newly developed, yet empirically reliable and valid measure for the assessment of parental satisfaction with the care provided by Neonatal Intensive Care Units (NICU). The present study aims to present the Greek version of the EMPATHIC-N and to confirm its factorial structure. Read More

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December 2018

MICRAT: a novel algorithm for inferring gene regulatory networks using time series gene expression data.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):115. Epub 2018 Dec 14.

School of Computing, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.

Background: Reconstruction of gene regulatory networks (GRNs), also known as reverse engineering of GRNs, aims to infer the potential regulation relationships between genes. With the development of biotechnology, such as gene chip microarray and RNA-sequencing, the high-throughput data generated provide us with more opportunities to infer the gene-gene interaction relationships using gene expression data and hence understand the underlying mechanism of biological processes. Gene regulatory networks are known to exhibit a multiplicity of interaction mechanisms which include functional and non-functional, and linear and non-linear relationships. Read More

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December 2018

Pathogenicity and molecular characterization of a fowl adenovirus 4 isolated from chicken associated with IBH and HPS in China.

BMC Vet Res 2018 Dec 14;14(1):400. Epub 2018 Dec 14.

College of Veterinary Medicine, Hebei Agricultural University, Baoding, 071001, Hebei, China.

Background: Since July in 2015, an emerging infectious disease, Fowl adenovirus (FAdV) species C infection with Hepatitis-Hydropericardium syndrome was prevalent in chicken flocks in China. In our study, one FAdV strain was isolated from commercial broiler chickens and was designated as SDSX1.The phylogenetic information, genetic mutations and pathogenicity of SDSX1 were evaluated. Read More

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December 2018

Using the behavior change wheel to identify barriers to and potential solutions for primary care clinical guideline use in four provinces in South Africa.

BMC Health Serv Res 2018 Dec 14;18(1):965. Epub 2018 Dec 14.

Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177, Stockholm, Sweden.

Background: Clinical practice guidelines risk having little impact on healthcare if not effectively implemented. Theory informed, targeted implementation may maximise their impact. Our study explored barriers to and facilitators of guideline implementation and use by South African primary care nurses and allied healthcare workers in four provinces in South Africa. Read More

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December 2018

Predictors of medical student interest in Indigenous health learning and clinical practice: a Canadian case study.

BMC Med Educ 2018 Dec 14;18(1):307. Epub 2018 Dec 14.

Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.

Background: Including content on Indigenous health in medical school curricula has become a widely-acknowledged prerequisite to reducing the health disparities experienced by Indigenous peoples in Canada. However, little is known about what levels of awareness and interest medical students have about Indigenous peoples when they enter medical school. Additionally, it is unclear whether current Indigenous health curricula ultimately improve students' beliefs and behaviours. Read More

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December 2018

Household food insecurity and coping strategies among pensioners in Jimma Town, South West Ethiopia.

BMC Public Health 2018 Dec 14;18(1):1373. Epub 2018 Dec 14.

Department of Health, Behaviour and Society, Jimma University, Jimma, Ethiopia.

Background: Ethiopia is currently facing new challenges related to food insecurity among the urban poor. Pensioners are segments of the population with reduced income and working capacity because of advancement of age and other related problems. There is no empirical evidence on Jimma Town pensioner's household food insecurity and coping strategies. Read More

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December 2018

Economic evaluations in community aged care: a systematic review.

BMC Health Serv Res 2018 Dec 14;18(1):967. Epub 2018 Dec 14.

Institute for Choice, University of South Australia Business School, Adelaide, SA, Australia.

Background: This paper reports the methods and findings from a systematic review of economic evaluations conducted in the community aged care sector between 2000 and 2016.

Methods: Online databases searched were PubMed, Medline, Scopus, and web of science, CINAHL and informit. Studies were included if they 1) were full economic evaluations that compared both the costs and outcomes of two or more interventions 2) in study population of people aged 65 years and over 3) dependent older people living in the community 4) alternatives being compared were care models or service delivery interventions in the community aged care sector (a group of programs that have been established as a support system to allow older people to remain living in their own homes for as long as possible, as an alternative to institutional or residential care) and 5) published in the English language between 2000 and November 2016. Read More

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December 2018

Dietary nutrient allocation to somatic tissue synthesis in emerging subimago freshwater mayfly Ephemera danica.

BMC Ecol 2018 Dec 14;18(1):57. Epub 2018 Dec 14.

Limnological Institute, University of Konstanz, Mainaustrasse 252, 78464, Constance, Germany.

Background: The relative importance of nutrients derived from different sources for tissue synthesis is crucial for predicting a species responds to changes in food availability. The ecological and physiological strategies that govern the incorporation and routing of nutrients for reproduction are often well understood. However, the role and adaptive value of both species and individual variation during early life-stage remain elusive. Read More

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December 2018

Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease.

BMC Med Genomics 2018 Dec 14;11(1):111. Epub 2018 Dec 14.

Centre for Pharmacology and Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Background: Non-alcoholic fatty liver disease (NAFLD) is a major health burden in need for new medication. To identify potential drug targets a genomic study was performed in lipid-laden primary human hepatocyte (PHH) and human hepatoma cell cultures.

Methods: PHH, HuH7 and HepG2 hepatoma cell cultures were treated with lipids and/or TNFα. Read More

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December 2018

The development of a survey instrument to measure the barriers to the conduct and application of research in complementary and alternative medicine: a Delphi study.

BMC Complement Altern Med 2018 Dec 14;18(1):335. Epub 2018 Dec 14.

Department of Rural Health, University of South Australia, North Terrace, Adelaide, SA, 5000, Australia.

Background: As Complementary and Alternative medicine (CAM) grows in popularity, there is overt recognition for research evidence to inform clinical practice. While various strategies have been trialed to overcome the barriers to such progress, it is important to first understand the extent to which these barriers impact the conduct and application of CAM research. This study aimed to garner consensus and agreement among CAM researchers and practitioners in refining and validating a preliminary survey instrument for measuring these barriers. Read More

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December 2018

Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):118. Epub 2018 Dec 14.

National Medical Centre of Colorectal Disease, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001, China.

Background: Bladder cancer (BC) is the most common cancer of the urinary bladder and upper tract, in which the clinical management is limited. AURKA (aurora kinase A) has been identified as an oncogene in cancer development; however, its potential role and underlying mechanisms in the progression of BC remain unknown.

Results: In this study, we evaluated Aurora kinase A (AURKA) expression in patient samples by performing gene expression profiling, and found that AURKA expression levels were significantly higher in BC tissues than in normal tissues. Read More

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December 2018
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Local anaesthesia training for undergraduate students - how big is the step from model to man?

BMC Med Educ 2018 Dec 14;18(1):308. Epub 2018 Dec 14.

Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nuremberg, Glückstrasse 11, 91054, Erlangen, Germany.

Background: Local anesthesia is an important skill and a prerequisite for most dental treatments. However, the step from theory to application on the patient is huge for the novice. Hence, a mannequin training model course was developed and implemented into the existing local anesthesia curriculum in undergraduate dental students. Read More

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December 2018

The prevalence and clinical seriousness of medication discrepancies identified upon hospital admission of pediatric patients.

BMC Health Serv Res 2018 Dec 14;18(1):966. Epub 2018 Dec 14.

Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Al-Hodeida University, Al-Hodeida, Yemen.

Background: Medication discrepancies are seen frequently in hospital setting upon admission or discharge. Medication Reconciliation service is a practice designed to ensure that patients' medications are ordered in a correct manner upon hospital admission, thus reducing the risk of having medication discrepancies. This study aimed to determine the prevalence of medication discrepancies and their clinical seriousness in pediatric patients at the time of hospital admission. Read More

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December 2018

Factors associated with overweight cats successfully completing a diet-based weight loss programme: an observational study.

BMC Vet Res 2018 Dec 14;14(1):397. Epub 2018 Dec 14.

Institute of Veterinary Science, University of Liverpool, Neston, UK.

Background: The most common approach for controlled weight loss in cats is dietary caloric restriction, using a purpose-formulated diet. Most previous studies have only assessed short-term outcomes, and no previous study has examined overall success (i.e. Read More

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December 2018

Recombinant Expression and Bioactivity Comparison of Four Typical Fungal Immunomodulatory Proteins from Three Main Ganoderma Species.

BMC Biotechnol 2018 Dec 14;18(1):80. Epub 2018 Dec 14.

Liaoning Province Key Laboratory of Agricultural Technology, College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, 110866, China.

Background: More than a dozen of fungal immunomodulatory proteins (FIPs) have been identified to date, most of which are from Ganoderma species. However, little is known about the similarities and differences between different Ganoderma FIPs' bioactivities. In the current study, two FIP genes termed FIP-gap1 and FIP-gap2 from G. Read More

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December 2018

Qualitative study exploring the phenomenon of multiple electronic prescribing systems within single hospital organisations.

BMC Health Serv Res 2018 Dec 14;18(1):969. Epub 2018 Dec 14.

Research Department of Practice and Policy, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.

Background: A previous census of electronic prescribing (EP) systems in England showed that more than half of hospitals with EP reported more than one EP system within the same hospital. Our objectives were to describe the rationale for having multiple EP systems within a single hospital, and to explore perceptions of stakeholders about the advantages and disadvantages of multiple systems including any impact on patient safety.

Methods: Hospitals were selected from previous census respondents. Read More

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December 2018

Exploring mental health practice among Traditional health practitioners: a qualitative study in rural Kenya.

BMC Complement Altern Med 2018 Dec 14;18(1):334. Epub 2018 Dec 14.

Africa Mental Health Foundation and Department of Psychiatry, University of Nairobi, Mawensi Road, Off Elgon road, Mawensi Garden, P.O. BOX 48423-00100, Nairobi, Kenya.

Background: Involvement of traditional health practitioners (THPs) in the form of collaboration with the formal health care system is suggested to improve the pathways to mental health care in Kenya, yet understanding of the current traditional practice and THPs' perspectives is lacking. The aim of this study was to explore the views of THPs with respect to their mental health practice.

Methods: This study qualitatively explored the views of THPs, using four focus group discussions (FDGs) each consisting of 8-10 traditional and faith healers, resulting in a total of 36 participants. Read More

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December 2018

Obstetric and perinatal outcomes of singleton pregnancies conceived via assisted reproductive technology complicated by gestational diabetes mellitus: a prospective cohort study.

BMC Pregnancy Childbirth 2018 Dec 14;18(1):495. Epub 2018 Dec 14.

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Firouzeh St., South Vali- Asr Ave., Vali- Asr Sq., Tehran, 15937-16615, Iran.

Background: Growing evidence indicates that the risk of obstetric and perinatal outcomes is higher in women with assisted reproductive technology (ART). However, there is little known about pregnancy related complications and co-morbidity in gestational diabetes mellitus (GDM) following singleton pregnancies achieved by ART in comparison with spontaneous conception (SC).

Methods: Two hundred sixty singleton pregnant women conceived by ART and 314 pregnant women conceived by spontaneous conception (SC) were participated in this prospective cohort study. Read More

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December 2018

Development and evaluation of a broadly reactive reverse transcription recombinase polymerase amplification assay for rapid detection of murine norovirus.

BMC Vet Res 2018 Dec 14;14(1):399. Epub 2018 Dec 14.

Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.

Background: Murine norovirus (MNV) is recognized as the most prevalent viral pathogen in captive mouse colonies. The rapid detection assay for MNV would be a useful tool for monitoring and preventing MNV infection. A recombinase polymerase amplification (RPA) assay was established in this study to provide a solution for rapid and sensitive detection of MNV. Read More

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December 2018

The emerging role of microRNA-4487/6845-3p in Alzheimer's disease pathologies is induced by Aβ25-35 triggered in SH-SY5Y cell.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):119. Epub 2018 Dec 14.

Department of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.

Background: Accumulation of amyloid β-peptide (Aβ) is implicated in the pathogenesis and development of Alzheimer's disease (AD). Neuron-enriched miRNA was aberrantly regulated and may be associated with the pathogenesis of AD. However, regarding whether miRNA is involved in the accumulation of Aβ in AD, the underlying molecule mechanism remains unclear. Read More

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December 2018

A rare case of intracardiac fibrosarcoma with myxoid features inducing venous occlusion in a dog - a case report.

BMC Vet Res 2018 Dec 14;14(1):398. Epub 2018 Dec 14.

Department of Pathology, University of Agricultural Sciences and Veterinary Medicine "Ion Ionescu de la Brad", Iași, Romania.

Background: In both humans and animals, cardiac fibrosarcoma is rare among primary cardiac malignant neoplasia. The overall prevalence of cardiac neoplasia in dogs is low, reported to be between 0.17% and 0. Read More

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December 2018
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