156,256 results match your criteria BMC Pediatrics [Journal]


The impact of integrin β2 on granulocyte/macrophage progenitor proliferation.

Stem Cells 2018 Dec 11. Epub 2018 Dec 11.

Beijing Key Laboratory od Diabetes Prevention and Research, Endocrinology Center, Lu He hospital, Capital Medical University, Beijing, China.

Rationale: Previously we reported that although the HSPC frequency in bone marrow cells (BMC) was comparable between β2-/- and β2+/+ mice, transplantation of β2-/- BMC into lethally irradiated CD45.1 recipient resulted in more myeloid cell production than β2+/+ BMC.

Objective: To address if integrin β2 deficiency skews granulocyte/macrophage progenitor (GMP) proliferation. Read More

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December 2018
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Study of pancreatic lipase inhibition kinetics and LC-QTOF-MS based identification of bioactive constituents of Momordica charantia fruits.

Biomed Chromatogr 2018 Dec 9:e4463. Epub 2018 Dec 9.

AB Sciex, Gurgaon, Haryana, India.

The different parts of Momordica charantia are well reported for its several therapeutic applications against hyperglycemia, hypercholesterolemia associated with pancreatic lipase (PL). Inhibition of this enzyme prevents the absorption of dietary triglyceride in the intestine, and thus exerts the anti-obesity effect. This study was aimed to investigate the bioactive constituents of the fruits of M. Read More

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December 2018
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Development of a high performance liquid chromatography method with fluorescence detection for the routine quantification of tamoxifen, endoxifen, and 4-hydroxytamoxifen in plasma from breast cancer patients.

Biomed Chromatogr 2018 Dec 9:e4462. Epub 2018 Dec 9.

Unidad de Investigación Médica Yucatan, Unidad Médica de Alta Especialidad, Centro Médico Ignacio García Téllez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico.

To date, several methods for quantification of tamoxifen and its metabolites have been developed, most of which employ liquid chromatography tandem-mass spectrometry (LC-MS/MS). These methods are highly sensitive and reproducible, but are also time-consuming and require expensive equipment; one of its main disadvantages is matrix ionization effects. A more viable option, particularly in developing countries, is high-performance liquid chromatography (HPLC) coupled with UV or fluorescence detection (FLD). Read More

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December 2018

Ultra high performance liquid chromatography with tandem mass spectrometry method for determination of four compounds in rat plasma after oral administration of Xanthii fructus and stir-fried Xanthii fructus extracts.

Biomed Chromatogr 2018 Dec 9:e4464. Epub 2018 Dec 9.

Engineering Center of State Ministry of Education for Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, China.

Xanthii fructus (XF), the fruit of Xanthium sibiricum Patr. is a traditional Chinese materia medica commonly used to treat allergic rhinitis (AR) and other rhinitis diseases. To uncover the mechanism of stir frying process and its effect on pharmacokinetic behavior of active compounds in model rats, four active compounds including chlorogenic acid, 4-caffeoylquinic acid, 1,5-O-dicaffeoylquinic acid and apigenin were selected based on previous spectrum-effect experiments. Read More

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December 2018

LC-ESI-MS/MS determination of copanlisib, a novel PI3K inhibitor in plasma and its application to a pharmacokinetic study in mice.

Biomed Chromatogr 2018 Dec 9:e4460. Epub 2018 Dec 9.

Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore, India.

A sensitive, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of copanlisib in mouse plasma using enasidenib as an internal standard (IS) as per regulatory guideline. Copanlisib and the IS were extracted from mouse plasma using ethyl acetate as an extraction solvent and chromatographed using an isocratic mobile phase (0.2% formic acid:acetonitrile; 25:75, v/v) on a HyPURITY C column. Read More

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December 2018

Determination of ospemifene in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.

Biomed Chromatogr 2018 Dec 7:e4451. Epub 2018 Dec 7.

Department of Chemistry, GITAM University, Hyderabad, India.

A highly sensitive, specific and rapid Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) analytical method has been developed and validated for the determination of ospemifene in human plasma using ospemifene-d as an internal standard. Solid phase extraction (SPE) technique with Phenomenex Strata X-33μM polymeric sorbent cartridges (30 mg/1ml) was used to extract the analytes from the plasma. The chromatographic separation was achieved on Agilent Eclipse XDB-Phenyl, 4. Read More

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December 2018

Simultaneous quantification of oxybutynin and its active metabolite N-desethyl oxybutynin in rat plasma by ultra high performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study of oxybutynin transdermal patch.

Biomed Chromatogr 2018 Dec 7:e4456. Epub 2018 Dec 7.

Department of Analytical Chemistry, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR China.

A rapid, selective and sensitive ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed to simultaneously determine oxybutynin (OB) and its active metabolite N-desethyl oxybutynin (DEOB) in rat plasma. Sample of 0.1 mL plasma was extracted with n-hexane. Read More

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December 2018

Preparation and in vitro/in vivo evaluation of anastrozole reservoir-type intravaginal ring.

Biomed Chromatogr 2018 Dec 9:e4459. Epub 2018 Dec 9.

National Research Institute for Family Planning, Beijing, China.

This report details the preparation of anastrozole (ATZ) reservoir-type intravaginal ring (IVR) and the detection the concentration of ATZ in Beagle dog plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS). An ATZ reservoir-type IVR which included ATZ silicone elastomer core and non-active silicone layer, was manufactured by reaction injection moulding at 80°C for 20 min. In vitro release experiment was performed under sink conditions and the samples are determined by high performance liquid chromatography (HPLC). Read More

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December 2018

Monitoring residue levels and dietary risk assessment of pymetrozine for Chinese consumption of cauliflower.

Biomed Chromatogr 2018 Dec 7:e4455. Epub 2018 Dec 7.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, P. R. China.

The present study investigates the occurrence of pymetrozine residues in cauliflower samples obtained from six cauliflower-producing areas of China during fixed time periods in 2017 and estimates the dietary risk of pymetrozine in cauliflower. A liquid chromatography with tandem mass spectrometry method was developed and validated to detect pymetrozine in cauliflower. The samples were extracted by 20 mL of acetonitrile and purified with dispersive solid-phase extraction using C as sorbent. Read More

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December 2018

Communication and comprehensive cancer control coalitions: lessons from two decades of campaigns, outreach, and training.

Cancer Causes Control 2018 Dec 10. Epub 2018 Dec 10.

Department of Kinesiology and Health Education, The University of Texas at Austin, 2109 San Jacinto Blvd. (D3700), Austin, TX, 78712-1415, USA.

Purpose: Comprehensive cancer control (CCC) coalitions and programs have delivered effective models and approaches to reducing cancer burden across the United States over the last two decades. Communication plays an essential role in diverse coalition activities from prevention to survivorship, including organizational and community capacity-building and as cancer control intervention strategies.

Methods: Based upon a review of published CCC research as well as public health communication best practices, this article describes lessons learned to assist CCC coalitions and programs with systematic implementation of communication efforts as key strategies in cancer control. Read More

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December 2018
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Angle-specific analysis of isokinetic quadriceps and hamstring torques and ratios in patients after ACL-reconstruction.

BMC Sports Sci Med Rehabil 2018 6;10:23. Epub 2018 Dec 6.

5Exercise Science and Neuroscience, Department of Exercise & Health, University of Paderborn, Warburger Str. 100, 33098 Paderborn, Germany.

Background: Strength deficits, muscle imbalances, and quadriceps inhibition are common after the surgical reconstruction of the anterior cruciate ligament (ACL), even after the patient's returned-to-sport. Typically, asymmetries between the operated and non-operated leg as well as the hamstring/quadriceps (HQ) ratio are calculated using maximum isokinetic torque values. Moreover, the knee flexion angles, which correspond to the measured torque values, were not considered. Read More

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December 2018
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Comparison of the kinematics and kinetics of shoulder exercises performed with constant and elastic resistance.

BMC Sports Sci Med Rehabil 2018 28;10:22. Epub 2018 Nov 28.

1Institute for Biomechanics, ETH Zürich, Leopold-Ruzicka-Weg 4, 8093 Zürich, Switzerland.

Background: Internal and external rotation exercises of the shoulder are frequently performed to avoid injury and pain. Knowledge about the motion and loadings of the upper extremities during these exercises is crucial for the development of optimal training recommendations. However, a comparison of the angles and corresponding moments in the upper extremities that are achieved during internal and external rotation exercises for the shoulder by using different resistance types has not yet been performed. Read More

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November 2018

Infections in patients with aplastic Anemia in Chiang Mai University.

BMC Hematol 2018 4;18:35. Epub 2018 Dec 4.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200 Thailand.

Background: Infection is a major complication in aplastic anemia (AA) patients. Primary objectives of this study were to determine the prevalence of infections and to determine types of pathogens associated with infections in patients with AA. Secondary objectives were to evaluate overall survival after infections as well as risk factors of infections in patients with AA. Read More

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December 2018

Direct reprogramming of fibroblasts into antigen-presenting dendritic cells.

Sci Immunol 2018 Dec;3(30)

Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, BMC A12, 221 84, Lund, Sweden.

Ectopic expression of transcription factors has been used to reprogram differentiated somatic cells toward pluripotency or to directly reprogram them to other somatic cell lineages. This concept has been explored in the context of regenerative medicine. Here, we set out to generate dendritic cells (DCs) capable of presenting antigens from mouse and human fibroblasts. Read More

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December 2018

Common femoral artery antegrade and retrograde approaches have similar access site complications.

J Vasc Surg 2018 Dec 4. Epub 2018 Dec 4.

Division of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass.

Objective: Ipsilateral antegrade access (AA) is an alternative access option for contralateral retrograde access (RA) in treating infrainguinal occlusive disease. Our goal was to assess whether AA is associated with higher access site complications.

Methods: The Vascular Quality Initiative database was searched from 2010 to 2017 for all infrainguinal peripheral vascular interventions. Read More

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December 2018

Implementation of a research capstone course with expanded flexibility.

Curr Pharm Teach Learn 2019 Jan 2;11(1):81-86. Epub 2018 Oct 2.

Department of Pharmacy and Health Systems Sciences, School of Pharmacy, Mail Stop R218 TF Northeastern University, 360 Huntington Avenue, Boston, MA 02115 United States. Electronic address:

Background And Purpose: A research-focused capstone course was designed to improve flexibility in the way pharmacy students meet the university's capstone requirement. The requirement aims to integrate knowledge, skills, and attitudes from didactic coursework and to apply them in a scholarly way to improve critical and evidence-based thinking, communication skills, and professionalism. This report describes the capstone course and faculty and student perceptions after the first year of implementation. Read More

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January 2019

Prevalence and associated factors of hypertension among adult patients in Felege-Hiwot Comprehensive Referral Hospitals, northwest, Ethiopia: a cross-sectional study.

BMC Res Notes 2018 Dec 10;11(1):876. Epub 2018 Dec 10.

College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.

Objective: The main objective of this study was to assess the prevalence and factors associated with hypertension among adult patients in Felege-Hiwot Comprehensive Referral Hospital, northwest Ethiopia, 2018.

Result: The prevalence of hypertension in the current study area was 27.3%. Read More

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December 2018

Epidemiology of potential drug-drug interactions in elderly population admitted to critical care units of Peshawar, Pakistan.

BMC Pharmacol Toxicol 2018 Dec 10;19(1):85. Epub 2018 Dec 10.

Department of Pharmacy, University of Malakand, Lower Dir District, Pakistan.

Background: Aging population, is a reality in many countries because of improvement in the health care, patient safety and other supplemental factors. Pharmacotherapy in this population must be evaluated due to their higher susceptibility to adverse drug outcomes, like potential drug-drug interactions (PDDIs). Research in this regard is limited particularly in developing countries. Read More

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December 2018

Effects of treatment with rituximab on microcirculation in patients with long-term systemic sclerosis.

BMC Res Notes 2018 Dec 10;11(1):874. Epub 2018 Dec 10.

State University of Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: To investigate the effect of rituximab on microcirculation in long-term SSc.

Results: Four patients with diffuse SSc over 3 years of disease received rituximab cycles of two 1-g infusions every 6 months for 2 years. Videocapillaroscopy was performed at baseline, 12 months, and 24 months and semi-quantitative scoring of videocapillaroscopy abnormalities was performed and the microangiopathy evolution score (MES: range 0-9) was calculated. Read More

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December 2018

Reliability of birth weight recall by parent or guardian respondents in a study of healthy adolescents.

BMC Res Notes 2018 Dec 10;11(1):878. Epub 2018 Dec 10.

Department of Public Health Sciences, Henry Ford Hospital, One Ford Place, 5C, Detroit, MI, 48202, USA.

Objective: Birth weight, which can be an indicator for risk of chronic diseases throughout the lifespan, is one of the most commonly used measures in the study of developmental origins of health and disease. There is limited information on the reliability of parent/guardian reported birth weight by race or by respondent type (i.e. Read More

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December 2018

Hepatitis C virus infections and associated risk factors in patients with diabetes mellitus; case control study in North West Tigray, Ethiopia.

BMC Res Notes 2018 Dec 10;11(1):873. Epub 2018 Dec 10.

Department of Public Health, College of Health Science, Aksum University, Aksum, Tigray, Ethiopia.

Objective: The objective of this study was to determine the seroprevalence of Hepatitis C virus among patients with Diabetes mellitus and healthy control groups in North West Tigray. Blood samples from each study subject was tested for Hepatitis C virus by using anti Hepatitis C virus antibody rapid test kits and confirmed using enzyme linked immuno sorbent assy.

Result: The overall seroprevalence of Hepatitis C virus, Hepatitis C virus among diabetic and non diabetic study subjects were found (16. Read More

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December 2018

Pregnant women adherence level to antenatal care visit and its effect on perinatal outcome among mothers in Tigray Public Health institutions, 2017: cohort study.

BMC Res Notes 2018 Dec 7;11(1):872. Epub 2018 Dec 7.

Department of Midwifery, Mekele University College of Health Sciences, Tigray, Ethiopia.

Objective: To assess pregnant women adherence level to antenatal care visit and its effect on perinatal outcome among mothers in Tigray Public Health institutions, 2017.

Results: The overall adherence level of the women towards to antenatal care visit was 49.9% and incidence of PPH, still birth, early neonatal death, late neonatal death and low birth weight complication was 4. Read More

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December 2018

A comparative quantitative study of utilizing artificial intelligence on electronic health records in the USA and China during 2008-2017.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):117. Epub 2018 Dec 7.

School of Information Science and Technology, Guangdong University of Foreign Studies, Guangzhou, China.

Background: The application of artificial intelligence techniques for processing electronic health records data plays increasingly significant role in advancing clinical decision support. This study conducts a quantitative comparison on the research of utilizing artificial intelligence on electronic health records between the USA and China to discovery their research similarities and differences.

Methods: Publications from both Web of Science and PubMed are retrieved to explore the research status and academic performances of the two countries quantitatively. Read More

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December 2018

A prospective study on dual time F-FDG-PET/CT in high-risk prostate cancer patients.

BMC Res Notes 2018 Dec 7;11(1):871. Epub 2018 Dec 7.

Department of Urology, Odense University Hospital, Odense, Denmark.

Objective: This proof of concept study investigated whether dual time point FDG-PET/CT with image acquisition after 1 and 3 h could be useful in preoperative staging of patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection for high-risk prostate cancer.

Results: Twenty patients with high-risk prostate cancer underwent dual time point FDG-PET/CT before undergoing surgery. Histologically confirmed lymph node metastases were found in 9/20 (45%). Read More

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December 2018

Young maternal age is a risk factor for child undernutrition in Tamale Metropolis, Ghana.

BMC Res Notes 2018 Dec 10;11(1):877. Epub 2018 Dec 10.

Department of Nutritional Sciences, School of Allied Health Sciences, University for Development Studies, P O Box TL 1883, Tamale, Ghana.

Objective: Malnutrition is a common cause of morbidity and mortality in children. The aim of this study was to compare the nutritional status of children under 5 years of teenage and adult mothers in Tamale Metropolis, Ghana. A case-control study involving 300 (150 cases, 150 controls) mother-child pairs was carried out. Read More

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December 2018

Evaluation of the acute flaccid paralysis (AFP) surveillance system in Mwenezi district, Masvingo, 2018: a descriptive study.

BMC Res Notes 2018 Dec 10;11(1):875. Epub 2018 Dec 10.

Department of Community Medicine, University of Zimbabwe, Harare, Zimbabwe.

Objectives: Poliomyelitis is an infectious disease caused by the polio virus which affects mostly young children below the age of 15 years. For surveillance children with acute flaccid paralysis (AFP) are tracked. In Zimbabwe every district should report two cases per 100,000 population of children under the age of 15 years old. Read More

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December 2018

Defining electronic-prescribing and infusion-related medication errors in paediatric intensive care - a Delphi study.

BMC Med Inform Decis Mak 2018 Dec 7;18(1):130. Epub 2018 Dec 7.

Our Lady's Children's Hospital, Crumlin, Dublin, 12, Ireland.

Background: The use of health information technology (HIT) to improve patient safety is widely advocated by governmental and safety agencies. Electronic-prescribing and smart-pump technology are examples of HIT medication error reduction strategies. The introduction of new errors on HIT implementation is, however, also recognised. Read More

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December 2018

Comparative features of infections of two Massachusetts (Mass) infectious bronchitis virus (IBV) variants isolated from Western Canadian layer flocks.

BMC Vet Res 2018 Dec 10;14(1):391. Epub 2018 Dec 10.

Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Health Research Innovation Center 2C53, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.

Background: Infectious bronchitis virus (IBV) is one of the leading causes of mortality and morbidity in chickens. There are numerous serotypes and variants, which do not confer cross protection resulting in failure of currently used IBV vaccines. Although variant IBV isolates with major genetic differences have been subjected to comparative studies, it is unknown whether minor genetic differences in IBV variants within a serotype are different in terms of pathogenesis and eliciting host responses. Read More

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December 2018

Simple and rationale-providing SMS reminders to promote accelerometer use: a within-trial randomised trial comparing persuasive messages.

BMC Public Health 2018 Dec 7;18(1):1352. Epub 2018 Dec 7.

Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.

Background: Literature on persuasion suggests compliance increases when requests are accompanied with a reason (i.e. the "because-heuristic"). Read More

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December 2018

Application of data mining methods to improve screening for the risk of early gastric cancer.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):121. Epub 2018 Dec 7.

College of Medical Information Engineering, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.

Background: Although gastric cancer is a malignancy with high morbidity and mortality in China, the survival rate of patients with early gastric cancer (EGC) is high after surgical resection. To strengthen diagnosing and screening is the key to improve the survival and life quality of patients with EGC. This study applied data mining methods to improve screening for the risk of EGC on the basis of noninvasive factors, and displayed important influence factors for the risk of EGC. Read More

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December 2018
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A patient-oriented clinical decision support system for CRC risk assessment and preventative care.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):118. Epub 2018 Dec 7.

Department of BioHealth Informatics, School of Informatics and Computing, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, IN, USA.

Background: Colorectal Cancer (CRC) is the third leading cause of cancer death among men and women in the United States. Research has shown that the risk of CRC associates with genetic and lifestyle factors. It is possible to prevent or minimize certain CRC risks by adopting a healthy lifestyle. Read More

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December 2018

Primary health information standard system based on semantic interoperability.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):112. Epub 2018 Dec 7.

The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: To realize semantic interoperability for Primary Health Information System (PHIS), this study analyzes and applies existing health information data standards in China. This research aims to establish a Primary Health Information Standard System (PHISS), and achieve the semantic level interoperability and application of primary health information.

Methods: First, the PHISS in accordance with the structural standards of national information standards system in China was constructed. Read More

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December 2018

How to assure access of essential RMNCH medicines by looking at policy and systems factors: an analysis of countdown to 2015 countries.

BMC Health Serv Res 2018 Dec 7;18(1):952. Epub 2018 Dec 7.

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.

Background: In 2000, the Millennium Development Goals set targets for social achievements by 2015 including goals related to maternal and child health, with mixed success. Several initiatives supported these goals including assuring availability of appropriate medicines and commodities to meet health service targets. To reach the new Sustainable Development Goals by 2030, information is needed to address policy and systems factors to improve access to lifesaving commodities. Read More

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December 2018

SBLC: a hybrid model for disease named entity recognition based on semantic bidirectional LSTMs and conditional random fields.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):114. Epub 2018 Dec 7.

School of Computer Science and Technology, Guangdong University of Technology, Guangzhou, China.

Background: Disease named entity recognition (NER) is a fundamental step in information processing of medical texts. However, disease NER involves complex issues such as descriptive modifiers in actual practice. The accurate identification of disease NER is a still an open and essential research problem in medical information extraction and text mining tasks. Read More

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December 2018

Mining and standardizing chinese consumer health terms.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):120. Epub 2018 Dec 7.

Institute of Medical Information, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, 100020, China.

Background: Health professionals and consumers use different terms to express medical events or concerns, which makes the communication barriers between the professionals and consumers. This may lead to bias in the diagnosis or treatment due to the misunderstanding or incomplete understanding. To solve the issue, a consumer health vocabulary was developed to map the consumer-used health terms to professional-used medical terms. Read More

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December 2018

An automated pipeline for analyzing medication event reports in clinical settings.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):113. Epub 2018 Dec 7.

School of Biomedical Informatics, University of Texas Health Science Center at Houston, 7000 Fannin Street, Suite 600, Houston, 77030, TX, USA.

Background: Medication events in clinical settings are significant threats to patient safety. Analyzing and learning from the medication event reports is an important way to prevent the recurrence of these events. Currently, the analysis of medication event reports is ineffective and requires heavy workloads for clinicians. Read More

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December 2018

Decline in HPV-vaccination uptake in Denmark - the association between HPV-related media coverage and HPV-vaccination.

BMC Public Health 2018 Dec 10;18(1):1360. Epub 2018 Dec 10.

Division of Infectious Disease Preparedness, Statens Serum Institut, 2300, Copenhagen, Artillerivej 5, Denmark.

Background: In 2014, Denmark experienced a rapid decline in vaccination uptake for the human papillomavirus (HPV) vaccine after a successful introduction of the vaccine in 2009. Before the decline, the uptake of the first HPV vaccine was around 90% for girls born in the period 1998 to 2000, while it dropped to 54% for girls born in 2003. The decline followed negative public attention from 2013 coinciding with increasing suspected adverse-event reporting to the Danish Medicines Agency. Read More

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December 2018

A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination setting-high coverage and safety, but no significant impact on transmission.

BMC Med 2018 Dec 10;16(1):215. Epub 2018 Dec 10.

Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Background: Mass drug administration (MDA) has the potential to interrupt malaria transmission and has been suggested as a tool for malaria elimination in low-endemic settings. This study aimed to determine the effectiveness and safety of two rounds of MDA in Zanzibar, a pre-elimination setting.

Methods: A cluster randomised controlled trial was conducted in 16 areas considered as malaria hotspots, with an annual parasite index of > 0. Read More

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December 2018

Randomized controlled trial to evaluate the utility of suction and inner-stylet of EBUS-TBNA for mediastinal and hilar lymphadenopathy.

BMC Pulm Med 2018 Dec 7;18(1):192. Epub 2018 Dec 7.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, China.

Background: The optimal procedure for maximizing the diagnostic yield and minimizing the procedural complexity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is controversial. We conducted a prospective randomized controlled trial to determine the optimal procedure of EBUS-TBNA for mediastinal and hilar lymphadenopathy, with a particular focus on the roles of the inner-stylet and suction.

Methods: Consecutive patients with enlarged mediastinal and hilar lymph nodes (LNs), detected by computed tomography (CT) or positron emission tomography-CT (PET-CT), who underwent EBUS-TBNA were included. Read More

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December 2018

Extract of Paecilomyces hepiali mycelia induces lipolysis through PKA-mediated phosphorylation of hormone-sensitive lipase and ERK-mediated downregulation of perilipin in 3T3-L1 adipocytes.

BMC Complement Altern Med 2018 Dec 7;18(1):326. Epub 2018 Dec 7.

School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.

Background: Cordyceps sinensis has been used for centuries in China as one of the most valued herbal medicine and tonic food. Paecilomyces hepiali, a fungal strain isolated from natural C. sinensis, has been used widely as a substitute of C. Read More

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December 2018

Conservation analysis and pathogenicity prediction of mutant genes of ectodysplasin a.

BMC Med Genet 2018 Dec 7;19(1):209. Epub 2018 Dec 7.

Department of Prosthodontics, Changsha Stomatological Hospital, Changsha, 410004, Hunan, China.

Background: Hypohidrotic ectodermal dysplasia (HED) is a common recessive X-linked hereditary disease that affects the development of ectoderm. Gene mutations of ectodysplasin A (EDA) play key roles in process of this disease. In our preliminary study, three unknown mutation sites (c. Read More

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December 2018

An audit of antimicrobial prescribing by dental practitioners in the north east of England and Cumbria.

BMC Oral Health 2018 Dec 10;18(1):206. Epub 2018 Dec 10.

Faculty of Health Sciences and Wellbeing, Sciences Complex, City Campus, Chester Road, University of Sunderland, Sunderland, SR1 3SD, UK.

Background: Inappropriate prescribing of antimicrobials is a significant threat to global public health. In England, approximately 5% of all antimicrobial items are prescribed by dentists, despite the limited indications for their use in the treatment of oral infections in published clinical guidelines. The objective of this study was to survey antimicrobial prescribing by dental practitioners in North East England and Cumbria, identify educational and training needs and develop a self-assessment tool that can be used for Continued Professional Development by individual practitioners. Read More

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December 2018

Prevalence of osteochondral lesions in the fetlock and hock joints of Standardbred horses that survived bacterial infection before 6 months of age.

BMC Vet Res 2018 Dec 10;14(1):390. Epub 2018 Dec 10.

Equine Section, Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ullevålsveien 72, 0454, Oslo, Norway.

Background: Young Standardbred horses frequently develop fragments in joints. Some fragments represent osteochondrosis; others are considered developmental, but it is uncertain whether they result from preceding osteochondrosis. Osteochondrosis occurs as a consequence of failure of the cartilage canal blood supply and ischaemic chondronecrosis. Read More

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December 2018

Fortification of Carica papaya fruit seeds to school meal snacks may aid Africa mass deworming programs: a preliminary survey.

BMC Complement Altern Med 2018 Dec 7;18(1):327. Epub 2018 Dec 7.

The Graduate School, Kenya Medical Research Institute, Mbagathi Road, Nairobi, P.O. BOX 54840, Kenya.

Background: Soil transmitted helminths (STHs) are among the world's neglected tropical diseases. Morbidity due to STHs is greatest in school-age children who typically have the highest burden of infection. In 2001, WHO passed a resolution for the use of large-scale mass drug administration (MDA) to deworm vulnerable children through school based programs. Read More

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December 2018

A longitudinal feature selection method identifies relevant genes to distinguish complicated injury and uncomplicated injury over time.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):115. Epub 2018 Dec 7.

Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA, 30322, USA.

Background: Feature selection and gene set analysis are of increasing interest in the field of bioinformatics. While these two approaches have been developed for different purposes, we describe how some gene set analysis methods can be utilized to conduct feature selection.

Methods: We adopted a gene set analysis method, the significance analysis of microarray gene set reduction (SAMGSR) algorithm, to carry out feature selection for longitudinal gene expression data. Read More

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December 2018

Bacteria and parasites in Podarcis sicula and P. sicula klemmerii.

BMC Vet Res 2018 Dec 10;14(1):392. Epub 2018 Dec 10.

Dipartimento di Medicina Veterinaria e Produzioni Animali, Università di Napoli Federico II, Naples, Italy.

Background: New epidemiological data on bacterial and parasitic infections in 24 Italian wall lizards, namely Podarcis sicula (mainland population) and P. sicula klemmerii (insular population) in southern Italy were provided. To achieve this goal, samples were collected from individuals belonging to the two populations and analysed by microbiological and parasitological methods. Read More

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December 2018

Process evaluation of a National Primary Eye Care Programme in Rwanda.

BMC Health Serv Res 2018 Dec 7;18(1):950. Epub 2018 Dec 7.

Africa Vision Research Institute, Durban, South Africa, University of Calabar, Calabar, Nigeria.

Background: Visual impairment is a global public health problem, with an estimated 285 million affected globally, of which 43% are due to refractive error. A lack of specialist eye care in low and middle-income countries indicates a new model of care would support a task-shifting model and address this urgent need. We describe the features and results of the process evaluation of a national primary eye care (PEC) programme in Rwanda. Read More

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December 2018

Perioperative management in a patient with type 1 diabetes mellitus who presented severe hypoglycemia during dental implant surgery: a case report.

BMC Oral Health 2018 Dec 7;18(1):204. Epub 2018 Dec 7.

Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, 4-1 Seiryomachi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Background: Patients with type 1 diabetes mellitus (DM) have poor glycemic control owing to extreme impairments in glucose tolerance. There are few reports regarding dental implant surgery in patients with type 1 DM. We describe herein the perioperative glycemic management in an outpatient with type 1 DM who experienced a rare case of severe hypoglycemia during dental implant surgery. Read More

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December 2018

Living at home after emergency hospital admission: prospective cohort study in older adults with and without cognitive spectrum disorder.

BMC Med 2018 Dec 11;16(1):231. Epub 2018 Dec 11.

Dementia and Ageing Research Group, Faculty of Social Science, University of Stirling, Stirling, FK9 4LA, Scotland.

Background: Cognitive spectrum disorders (CSDs) are common in hospitalised older adults and associated with adverse outcomes. Their association with the maintenance of independent living has not been established. The aim was to establish the role of CSDs on the likelihood of living at home 30 days after discharge or being newly admitted to a care home. Read More

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December 2018

Undergraduate medical education in Sierra Leone: a qualitative study of the student experience.

BMC Med Educ 2018 Dec 7;18(1):298. Epub 2018 Dec 7.

Independent Researcher, Liverpool, UK.

Background: Sierra Leone, a low-income and post-conflict country, has an extreme shortage of qualified medical doctors. Given the complex challenges facing medical education in this country and the need for context-specific knowledge, the aim of this paper is to explore the undergraduate medical education experience in Sierra Leone through qualitative interviews with recent graduates.

Methods: In-depth interviews were conducted with purposively sampled junior doctors (n = 15) who had graduated from the only medical school in Sierra Leone. Read More

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December 2018