2,370 results match your criteria BMC Pediatrics [Journal]


A case report of a teenager with severe hand, foot, and mouth disease with brainstem encephalitis caused by enterovirus 71.

BMC Pediatr 2019 Feb 13;19(1):59. Epub 2019 Feb 13.

Intensive Care Unit, Key Medical Laboratory of Pediatrics, Chongqing Health Bureau, Ministry of Education; Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Hand, foot, and mouth disease (HFMD) is an acute viral infection occurring mostly in infants and children. Enterovirus 71 (EV71) infection mostly occurs in children < 5 years of age. Severe cases, however, are usually encountered in children under the age of 3 years, and exceedingly rare in teenagers > 14 years and adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1428-4DOI Listing
February 2019

First experience with Tolvaptan for the treatment of neonates and infants with capillary leak syndrome after cardiac surgery.

BMC Pediatr 2019 Feb 12;19(1):57. Epub 2019 Feb 12.

Department of Pediatric Cardiology, University of Erlangen-Nürnberg, Loschgestrasse 15, 91054, Erlangen, Germany.

Background: Postoperative fluid management in critically ill neonates and infants with capillary leak syndrome (CLS) and extensive volume overload after cardiac surgery on cardiopulmonary bypass is challenging. CLS is often resistant to conventional diuretic therapy, aggravating the course of weaning from invasive ventilation, increasing length of stay on ICU and morbidity and mortality.

Methods: Tolvaptan (TLV, vasopressin type 2 receptor antagonist) was used as an additive diuretic in neonates and infants with CLS after cardiac surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1418-6DOI Listing
February 2019

Macronutrient content of pooled donor human milk before and after Holder pasteurization.

BMC Pediatr 2019 Feb 12;19(1):58. Epub 2019 Feb 12.

NICU Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Donor human milk (DHM) is the best alternative for preterm infants when their own mother's milk is unavailable. DHM should be pasteurized to guarantee microbiological safety; however, this process can influence the macronutrient content. The aim of this study was to investigate the effect of Holder pasteurization (HoP) on DHM macronutrient content. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1427-5DOI Listing
February 2019

Prevalence and burden of illness of treated hemolytic neonatal hyperbilirubinemia in a privately insured population in the United States.

BMC Pediatr 2019 Feb 11;19(1):53. Epub 2019 Feb 11.

HealthCore, Inc., An Independent Subsidiary of Anthem, Inc, Wilmington, DE, 19801, USA.

Background: Prevalence of hemolytic neonatal hyperbilirubinemia (NHB) is not well characterized, and economic burden at the population level is poorly understood. This study evaluated the prevalence, clinical characteristics, and economic burden of hemolytic NHB newborns receiving treatment in U.S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1414-xDOI Listing
February 2019
1 Read

Cross-sectional associations of objectively assessed sleep duration with physical activity, BMI and television viewing in German primary school children.

BMC Pediatr 2019 Feb 11;19(1):54. Epub 2019 Feb 11.

Division of Sports and Rehabilitation Medicine, Department of Internal Medicine II, Ulm University Medical Centre, Leimgrubenweg 14, D-89075, Ulm, Germany.

Background: The global incidence of overweight and obesity has increased dramatically among children and adolescents over the past decades. Insufficient sleep duration and physical inactivity are known risk factors for overweight and obesity in children. To engage children in a healthier lifestyle knowledge about associations of sleep duration and behavioural aspects in children are vital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1429-3DOI Listing
February 2019

Endocrine and metabolic complications in children and adolescents with Sickle Cell Disease: an Italian cohort study.

BMC Pediatr 2019 Feb 11;19(1):56. Epub 2019 Feb 11.

Post Graduate School of Pediatrics, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124, Modena, Italy.

Background: Children with Sickle Cell Disease (SCD) show endocrine complications and metabolic alterations. The physiopathology of these conditions is not completely understood: iron overload due to chronic transfusions, ischemic damage, and inflammatory state related to vaso-occlusive crises may be involved. Aims of this study were to evaluate the growth pattern, endocrine complications, and metabolic alterations and to detect the relationship between these conditions and the SCD severity in affected children and adolescents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1423-9DOI Listing
February 2019
1 Read

A 10-year-old boy with dyspnea and hypoxia: abernathy malformation masquerading as pulmonary arteriovenous fistula.

BMC Pediatr 2019 Feb 11;19(1):55. Epub 2019 Feb 11.

Department of Cardiology, Shanghai Children's Hospital, Shanghai Jiaotong University, No. 355 Luding Road, Shanghai, 200062, China.

Background: Abernethy malformation is an extremely rare congenital malformation characterised by an extrahepatic portosystemic shunt. Children with Abernathy malformation can develop hepatopulmonary syndrome (HPS) with pulmonary arteriovenous fistulas (PAVF) or pulmonary hypertension. PAVF manifests as central cyanosis with effort intolerance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1422-xDOI Listing
February 2019
1 Read

Infant mortality in Brazil attributable to inborn errors of metabolism associated with sudden death: a time-series study (2002-2014).

BMC Pediatr 2019 Feb 8;19(1):52. Epub 2019 Feb 8.

Graduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Background: The literature suggests that 0.9 to 6% of infants who die unexpectedly may have had a metabolic disorder. At least 43 different inborn errors of metabolism (IEMs) have been associated with sudden death (SUDI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1421-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367785PMC
February 2019

Safety and immunogenicity of a varicella vaccine without human serum albumin (HSA) versus a HSA-containing formulation administered in the second year of life: a phase III, double-blind, randomized study.

BMC Pediatr 2019 Feb 7;19(1):50. Epub 2019 Feb 7.

GSK, Avenue Fleming 20, B-1300, Wavre, Belgium.

Background: A new formulation of the live-attenuated varicella vaccine Varilrix (GSK) produced without human serum albumin (HSA) was developed to minimize a theoretical risk of transmission of infectious diseases. A previous study showed that the vaccine was immunologically non-inferior to the HSA-containing vaccine and well-tolerated in toddlers; low-grade fever was numerically higher in children receiving the vaccine without HSA, but the study lacked power to conclude on this difference.

Methods: In this phase III, double-blind, multi-center study, healthy 12-23-month-olds were randomized (1:1) to receive two doses of the varicella vaccine without (Var-HSA group) or with HSA (Var + HSA group) at days 0 and 42. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-019-1425-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366055PMC
February 2019
13 Reads

A systematic review of the diagnostic accuracy of Loop-mediated-isothermal AMPlification (LAMP) in the diagnosis of invasive meningococcal disease in children.

BMC Pediatr 2019 Feb 7;19(1):49. Epub 2019 Feb 7.

Centre for Experimental Medicine, Queen's University Belfast, Wellcome Wolfson Institute of Experimental Medicine, 97 Lisburn Road, Belfast, BT9 7AE, UK.

Background: The early recognition of meningococcal disease in children is vital. During the prodrome however, meningococcal infection presents similarly to many self-limiting viral infections. This mandates a cautious approach with many children receiving unnecessary broad-spectrum parenteral antibiotics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1403-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366060PMC
February 2019
2 Reads

Structured on-the-job training to improve retention of newborn resuscitation skills: a national cohort Helping Babies Breathe study in Tanzania.

BMC Pediatr 2019 Feb 7;19(1):51. Epub 2019 Feb 7.

Division of Global Health, Department of Pediatrics, Massachusetts General Hospital, 125 Nashua Street, 8th Floor, Boston, MA, 02114, USA.

Background: Newborn resuscitation is a life-saving intervention for birth asphyxia, a leading cause of neonatal mortality. Improving provider newborn resuscitation skills is critical for delivering quality care, but the retention of these skills has been a challenge. Tanzania implemented a national newborn resuscitation using the Helping Babies Breathe (HBB) training program to help address this problem. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1419-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366017PMC
February 2019
1 Read

Nonsynostotic plagiocephaly: a child health care intervention in Skaraborg, Sweden.

BMC Pediatr 2019 Feb 6;19(1):48. Epub 2019 Feb 6.

The Skaraborg Institute for Research and Development, Stationsgatan 12, 541 30, Skövde, Sweden.

Background: The aim was to evaluate the intervention's effect on prevention and reversal of nonsynostotic plagiocephaly.

Methods: Thirty-eight intervention group nurses were educated about nonsynostotic plagiocephaly and asked to follow guidelines; 18 control group nurses were not. In a longitudinal single-blinded clinical intervention, parents brought infants to well-child visits according to the national schedule. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1405-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364473PMC
February 2019
1 Read

High level of treatment failure and drug resistance to first-line antiretroviral therapies among HIV-infected children receiving decentralized care in Senegal.

BMC Pediatr 2019 Feb 5;19(1):47. Epub 2019 Feb 5.

Bacteriology-Virology Laboratory, A. Le Dantec CHU, Cheikh Anta Diop University, Dakar, Senegal.

Background: In Senegal in 2015, an estimated 4800 children were living with HIV, with 1200 receiving ARV treatment, of whom half had follow-up care in decentralized sites outside Dakar. However, until now no studies have determined the efficacy of pediatric treatment in decentralized settings, even though the emergence of viral resistance, particularly among children in Africa, is a well-known phenomenon. This study aimed to assess the virological status of HIV-infected children in all decentralized facilities to help improve access to quality care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1420-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362577PMC
February 2019

Parents' self-directed practices towards the use of antibiotics for upper respiratory tract infections in Makkah, Saudi Arabia.

BMC Pediatr 2019 Feb 4;19(1):46. Epub 2019 Feb 4.

Department of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Background: Excessive and inappropriate antimicrobial use in the community is one risk factor that can result in the spread of antimicrobial resistance. Upper respiratory tract infections are most frequently reported among children and mainly of viral origin and do not require antibiotics. We have conducted Knowledge, Attitude and Perception (KAP) survey of parents to explore the parent's knowledge, attitude & perception of Saudi parents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360761PMC
February 2019
3 Reads
1.918 Impact Factor

Performance characteristics of a local triage tool and internationally validated tools among under-fives presenting to an urban emergency department in Tanzania.

BMC Pediatr 2019 Feb 1;19(1):44. Epub 2019 Feb 1.

Department of Emergency Medicine, University of California, San Francisco, California, USA.

Background: A number of region-specific validated triage systems exist; however very little is known about their performance in resource limited settings. We compare the local triage tool and internationally validated tools among under-fives presenting to an urban emergency department in Tanzania.

Methodology: Prospective descriptive study of consecutive under-fives seen at Muhimbili National Hospital (MNH), ED between November 2017 to April 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1417-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357459PMC
February 2019
2 Reads

The evolving epidemiology of rotavirus A infection in Brazil a decade after the introduction of universal vaccination with Rotarix®.

BMC Pediatr 2019 Jan 31;19(1):42. Epub 2019 Jan 31.

Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brasil 4365 Pavilhão Hélio e Peggy Pereira, Manguinhos, Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Brazil introduced the monovalent rotavirus vaccine (Rotarix®) in 2006. This study aimed to assess the epidemiology and genotype distribution of species-A rotavirus (RVA) in Brazil, comparing the pre- and post-vaccination periods.

Methods: Laboratory-based RVA surveillance included 866 municipalities in 22 Brazilian states, over a 21-year period. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-019-1415-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354375PMC
January 2019
2 Reads

Quality of care and suspected developmental delay among children aged 1-59 months: a cross-sectional study in 8 counties of rural China.

BMC Pediatr 2019 Jan 31;19(1):41. Epub 2019 Jan 31.

Department of Maternal and Child Health, School of Public Health, Peking University, No. 38 Xueyuan Road, Haidian District, Beijing, 100191, China.

Background: The data about quality of care of more than 70 countries were available from UNICEF but little was known about China. We examined the status about quality of care and explored its associations with developmental outcomes in Chinese children.

Methods: A cross-sectional study with probability proportional to size sampling method was conducted in 8 counties of rural China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1406-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354395PMC
January 2019

Lessons from a patient with cardiac arrest due to massive pulmonary embolism as the initial presentation of Wilms tumor: a case report and literature review.

BMC Pediatr 2019 Jan 31;19(1):39. Epub 2019 Jan 31.

Department of Pediatrics, JA Toride Medical Center, 2-1-1, Hongo, Toride, Ibaraki, Japan.

Background: Finding an abdominal mass or hematuria is the initial step in diagnosing Wilms tumor. As the first manifestation of Wilms tumor, it is exceedingly rare for pulmonary tumor embolism to present with cardiac arrest. A case of a patient whose sudden cardiac arrest due to massive pulmonary tumor embolism of Wilms tumor was not responsive to resuscitation is presented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1413-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354414PMC
January 2019
2 Reads

Distribution of distinct subsets of circulating T follicular helper cells in Kawasaki disease.

BMC Pediatr 2019 Jan 31;19(1):43. Epub 2019 Jan 31.

Department of Pediatric Rheumatology and Allergy, The First Hospital of Jilin University, Changchun, 130021, China.

Background: Kawasaki disease (KD) is an acute febrile vasculitis that primarily affects children. Previous studies have shown that both innate and adapt immune systems are involved in the immunopathogenesis of KD. The following study analyzes the distribution of the subsets of Circulating T follicular helper cells (cTfh cells) in KD patients with and without coronary artery lesions (CALs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1412-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357512PMC
January 2019
1 Read

Reliability and accuracy of smartphones for paediatric infectious disease consultations for children with rash in the paediatric emergency department.

BMC Pediatr 2019 Jan 31;19(1):40. Epub 2019 Jan 31.

Department of Pediatric Emergency Department, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Objective: Smartphones and associated messaging applications have become the most common means of communication among health care workers and the general population. The aim of this study was to evaluate the reliability and accuracy of smartphones for the diagnosis of rash in children admitted to emergency departments during the night shift.

Methods: The images of the children who were admitted to the paediatric emergency department with rash were included in this study, and at least two images taken with smartphones by residents or paediatric infectious disease fellows were re-directed to the chief consultant of the Paediatric-Infectious Department via smartphone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1416-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354364PMC
January 2019
1 Read

Sail sign in neonatal pneumomediastinum: a case report.

BMC Pediatr 2019 Jan 31;19(1):38. Epub 2019 Jan 31.

NSW Newborn & Paediatric Emergency Transport Service, Sydney, Australia.

Background: Pneumomediastinum is an uncommon cause of neonatal respiratory distress. Clinical history and examination of the neonate may be uninformative in determining the aetiology of the respiratory distress. Chest x-ray can be diagnostic of pneumomediastinum however is often difficult to interpret. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1397-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354351PMC
January 2019
3 Reads

Cognitive and motor outcomes in children born low birth weight: a systematic review and meta-analysis of studies from South Asia.

BMC Pediatr 2019 Jan 29;19(1):35. Epub 2019 Jan 29.

Indian Institute of Technology (IIT), New Delhi, India.

Background: South Asia contributes substantially to global low birth weight population (i.e. those with birth weight < 2500 g). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1408-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350290PMC
January 2019
1 Read
1.918 Impact Factor

Predictors of treatment failure, time to switch and reasons for switching to second line antiretroviral therapy in HIV infected children receiving first line anti-retroviral therapy at a Tertiary Care Hospital in Ethiopia.

BMC Pediatr 2019 Jan 29;19(1):37. Epub 2019 Jan 29.

Department of Pharmacology and Clinical Pharmacy, School of Pharmacy , College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Treatment failure and delay in switching to second line regimen are major concerns in the treatment of HIV infected children in a resource limited setting. The aim of this study was to determine the prevalence and predictors of first line antiretroviral therapy (ART) regimen failure, reasons and time taken to switch to second line antiretroviral (ARV) medications after treatment failure among HIV-infected children.

Methods: A retrospective cohort study was conducted February 2003 to May 2018 in HIV-clinic at Tikur Anbessa Specialized Hospital (TASH), Ethiopia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1402-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352354PMC
January 2019

Clinical, etiological and antimicrobial susceptibility profile of pediatric urinary tract infections in a tertiary care hospital of Nepal.

BMC Pediatr 2019 Jan 29;19(1):36. Epub 2019 Jan 29.

Department of Microbiology and Infectious Diseases, B. P. Koirala Institute of Health Sciences, Dharan, Sunsari, 56700, Nepal.

Background: Urinary tract infection (UTI) is one of most common pediatric infections. The study was designed to assess the clinical profile, common bacterial microorganisms causing UTI and their antimicrobial susceptibility patterns at B. P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1410-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350346PMC
January 2019
1 Read

Bariatric surgery in adolescents: a prospective randomized controlled trial comparing laparoscopic gastric banding to combined lifestyle interventions in adolescents with severe obesity (BASIC trial).

BMC Pediatr 2019 Jan 28;19(1):34. Epub 2019 Jan 28.

NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

Background: Obesity in children and adolescents is an increasing problem associated with multiple co-morbidities including metabolic and endocrine changes, cardiovascular abnormalities, and impaired quality of life. Combined lifestyle interventions are the current standard treatment for severe obesity in children. However, the medium- and long-term results of these interventions are relatively poor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1395-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350363PMC
January 2019
2 Reads

Time-to-recovery from severe acute malnutrition in children 6-59 months of age enrolled in the outpatient treatment program in Shebedino, Southern Ethiopia: a prospective cohort study.

BMC Pediatr 2019 Jan 28;19(1):33. Epub 2019 Jan 28.

School of Public Health, Hawassa University, Hawassa city, Ethiopia.

Background: In Ethiopia uncomplicated severe acute malnutrition (SAM) is managed at health posts level through the outpatient therapeutic program (OTP). Yet, evidence on the treatment success rate of the program is scarce. This study determines the treatment outcomes and predictors of time-to-recovery among children 6-59 months of age with SAM managed at the health posts level in Shebedino district, Southern Ethiopia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1407-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348627PMC
January 2019
1 Read

Deciphering risk factors for blood stream infections, bacteria species and antimicrobial resistance profiles among children under five years of age in North-Western Tanzania: a multicentre study in a cascade of referral health care system.

BMC Pediatr 2019 Jan 26;19(1):32. Epub 2019 Jan 26.

Department of Microbiology and Immunology, Weill-Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.

Background: Blood stream infections (BSIs) cause a complex cascade of inflammatory events, resulting in significant morbidity and mortality in children in Tanzania. This study was designed to delineate circulating bacterial species, antimicrobial resistance (AMR) profiles and risk factors for BSIs and mortality among children in the cascade of referral health care facilities so as to guide comprehensive BSIs management.

Methods: A multiple cross sectional analytical study was conducted between July 20, 2016 to October 04, 2017 involving 950 children less than five years of age in the North-western part of Tanzania. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1411-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347777PMC
January 2019
1 Read

Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: study protocol.

BMC Pediatr 2019 Jan 26;19(1):31. Epub 2019 Jan 26.

Medical Innovation Promotion Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

Background: There is no established standard chemotherapy for recurrent pediatric solid tumors such as neuroblastoma and sarcoma. Since some of these tumor cells show dysfunctions in homologous recombination repair, the goal is to conduct a phase I study of olaparib, a poly(ADP-ribose) polymerase inhibitor. In this clinical trial, the aims are to evaluate the safety, tolerability, and efficacy of olaparib in pediatric patients with refractory solid tumors and to recommend a dose for phase II trials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1409-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347807PMC
January 2019
1 Read

"From the moment I wake up I will use it…every day, very hour": a qualitative study on the patterns of adolescents' mobile touch screen device use from adolescent and parent perspectives.

BMC Pediatr 2019 Jan 24;19(1):30. Epub 2019 Jan 24.

School of Physiotherapy and Exercise Science, Curtin University, Kent Street Bentley, Perth, WA, 6845, Australia.

Background: The use of mobile touch screen devices, e.g. smartphones and tablet computers, has become increasingly prevalent among adolescents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1399-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346550PMC
January 2019
1 Read

A health systems strengthening intervention to improve quality of care for sick and small newborn infants: results from an evaluation in district hospitals in KwaZulu-Natal, South Africa.

BMC Pediatr 2019 Jan 24;19(1):29. Epub 2019 Jan 24.

KwaZulu-Natal Department of Health, Pietermaritzburg, South Africa.

Background: Many newborn infants die from preventable causes in South Africa, often these deaths occur in district hospitals. A multipronged intervention aiming to improve quality of newborn care in district hospitals was implemented comprising training in clinical care for sick and small newborns, skills development for health managers, on-site mentoring, and hospital accreditation. We present the results of the project evaluation. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-019-1396-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345064PMC
January 2019
3 Reads

Myocardial oedema in an 8-year-old Chinese boy with Idiopathic systemic capillary leak syndrome.

BMC Pediatr 2019 Jan 21;19(1):28. Epub 2019 Jan 21.

Department of Paediatric Cardiology, Queen Mary Hospital, Room 322, New Clinical Building, 102 Pokfulam Road, Pokfulam, Hong Kong.

Background: Idiopathic systemic capillary leak syndrome (ISCLS) is rare, and there has been about 32 cases reported in children worldwide since this disorder was first described in 1960. Clinical guidelines on the management approach stemming from robust scientific evidence are lacking. This case report presents the first reported paediatric case of severe ISCLS with significant myocardial oedema and emphasizes this disease's impact on a child's cardiac function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1401-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340176PMC
January 2019
3 Reads

Risk factors for recurrent severe anemia among previously transfused children in Uganda: an age-matched case-control study.

BMC Pediatr 2019 Jan 18;19(1):27. Epub 2019 Jan 18.

Department of Global Child Health, Emma Children's Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Background: In resource-poor settings, transfused children often experience recurrence of severe anemia (SA) following discharge from hospital. This study determined the factors associated with recurrent severe anemia (RSA) among previously transfused Ugandan children aged less than 5 years.

Methods: A case-control study was conducted in five hospitals in Uganda from March 2017 to September 2018. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-019-1398-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337863PMC
January 2019
8 Reads

Developmental outcomes of preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension at 18-24 months of corrected age.

BMC Pediatr 2019 Jan 17;19(1):26. Epub 2019 Jan 17.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, Republic of Korea.

Background: Owing to advances in the critical care of premature infants with bronchopulmonary dysplasia (BPD), BPD-associated pulmonary hypertension (PH) is becoming a growing concern. However, only few investigations were available on neurodevelopmental outcomes in preterm infants with PH. Therefore, this study aimed to identify the impact of PH on growth and neurodevelopment at 18-24 months of corrected age (CA). Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-019-1400-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337852PMC
January 2019
4 Reads

The subject-dependent, cumulative, and recency association of aerobic fitness with academic performance in Taiwanese junior high school students.

BMC Pediatr 2019 Jan 17;19(1):25. Epub 2019 Jan 17.

Department of Physical Education, No.162, Sec. 1, Heping E. Rd., Da'an Dist., Taipei, 10610, Taiwan, Republic of China.

Background: The objective of the current study was to examine whether the relation between aerobic fitness and academic achievement during adolescence is subject-dependent, and to investigate cumulative and recency effects.

Methods: This study made use of two nationwide datasets. The first was the aerobic fitness profile of junior high school students collected by the Ministry of Education in Taiwan. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-018-1384-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337796PMC
January 2019
4 Reads

Diagnosis and antibiotic treatment of group a streptococcal pharyngitis in children in a primary care setting: impact of point-of-care polymerase chain reaction.

BMC Pediatr 2019 Jan 16;19(1):24. Epub 2019 Jan 16.

Roche Molecular Systems, Pleasanton, CA, USA.

Background: To compare the sensitivity and specificity of the recommended 2-step rapid antigen detection test (RADT) with confirmatory culture vs the point-of-care (POC) polymerase chain reaction (PCR) Roche cobas® Liat® Strep A test for detection of group A Streptococcus (GAS) in pediatric patients with pharyngitis, and to investigate the impact of these tests on antibiotic use in a large pediatric clinic.

Methods: This prospective, open-label study was conducted at a single site during fall/winter 2016-2017. A total of 275 patients aged 3 to 18 years with symptoms of pharyngitis had a throat-swab specimen analyzed using RADT, POC PCR, and culture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1393-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335697PMC
January 2019
2 Reads

Do video game interventions improve motor outcomes in children with developmental coordination disorder? A systematic review using the ICF framework.

BMC Pediatr 2019 Jan 16;19(1):22. Epub 2019 Jan 16.

Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.

Background: Children with developmental coordination disorder (DCD) experience a range of difficulties that can potentially limit their academic, social and physical ability. Recent research has developed interventions that aim to improve motor outcomes in a variety of paediatric cohorts using video gaming equipment. Therefore, we aimed to systematically review the literature on virtual reality or video game interventions that aim to improve motor outcomes in children with DCD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1381-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335818PMC
January 2019
2 Reads

The association between antibiotics in the first year of life and child growth trajectory.

BMC Pediatr 2019 Jan 16;19(1):23. Epub 2019 Jan 16.

Department of Pediatrics, UCSD School of Medicine, University of California San Diego, 9500 Gilman Drive, MC 0874, La Jolla, CA, San Diego, CA, 92093, USA.

Background: Antibiotics are frequently prescribed to children, and may be an environmental influence that contributes to the increasing prevalence of childhood obesity. The aim of this study was to examine the effect of antibiotic use in the first year of life on child growth trajectories from birth to age 6 years including significant covariates.

Methods: Data from 586 children in the Infant Feeding Practices II (IFPS II) and 6 year follow-up study (6YFU) were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1363-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335775PMC
January 2019
2 Reads

Cross-cultural validation of the Bengali version KIDSCREEN-27 quality of life questionnaire.

BMC Pediatr 2019 Jan 15;19(1):19. Epub 2019 Jan 15.

Discipline of Child and Adolescent Health, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.

Background: Measuring the health-related quality of life (HRQoL) of adolescents, including those with cerebral palsy (CP) (the major cause of childhood physical disability worldwide) in Bangladesh is pertinent although there is a dearth of validated instruments for assessing this concept. For application in a case-control study comparing HRQoL between adolescents with CP and peers without disability in Bangladesh (a typical low- and middle-income country) we cross-culturally translated and psychometrically tested KIDSCREEN-27.

Methods: KIDSCREEN-27 was translated to Bengali using forward and backwards translation protocol and interviewer administered to adolescents with CP and their age and sex matched peers without disability. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-018-1373-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334442PMC
January 2019
10 Reads

Occult child abuse presenting as pneumatosis intestinalis and portomesenteric venous gas - a case report.

BMC Pediatr 2019 Jan 15;19(1):21. Epub 2019 Jan 15.

Department of Pediatric Emergency Medicine, Children's Hospital, China Medical University, Taichung, Taiwan.

Background: Pneumatosis intestinalis and portomesenteric venous gas are usually caused by necrotizing enterocolitis; however they can occur secondary to abusive abdominal trauma with bone fractures and bruising. It is difficult to recognize initially if there is no bruising on the skin or bone fractures.

Case Presentation: We report a 1-year-old child with no obvious history of trauma who presented with conscious disturbance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1382-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334378PMC
January 2019
3 Reads

The influence of gestational age in the psychometric testing of the Bernese Pain Scale for Neonates.

BMC Pediatr 2019 Jan 15;19(1):20. Epub 2019 Jan 15.

Division of Midwifery, Department of Health Professions, Bern University of Applied Sciences, Murtenstrasse 10, 3008, Bern, Switzerland.

Background: Assessing pain in neonates is challenging because full-term and preterm neonates of different gestational ages (GAs) have widely varied reactions to pain. We validated the Bernese Pain Scale for Neonates (BPSN) by testing its use among a large sample of neonates that represented all GAs.

Methods: In this prospective multisite validation study, we assessed 154 neonates between 24 2/7 and 41 4/7 weeks GA, based on the results of 1-5 capillary heel sticks in their first 14 days of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1380-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334397PMC
January 2019
5 Reads

Risk factors associated with mortality in neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and clinical implications.

BMC Pediatr 2019 Jan 14;19(1):18. Epub 2019 Jan 14.

Department of Hepatology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Background: Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) has high prevalence in East Asia, and has been reported in other parts of the world. NICCD is also the most common form of genetic cholestasis among East Asians. There has been reports of mortalities or liver transplants associated with NICCD, but risk factors associated with poor outcome were unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1383-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330752PMC
January 2019
2 Reads
1.918 Impact Factor

Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response.

BMC Pediatr 2019 Jan 12;19(1):17. Epub 2019 Jan 12.

Mallinckrodt Pharmaceuticals, Bedminster, NJ, USA.

Background: Substantial numbers of neonates with hypoxic respiratory failure (HRF) do not immediately respond to inhaled nitric oxide (iNO) and are often labeled as non-responders. This retrospective data analysis assessed time to treatment response in the iNO key registration trial.

Methods: Treatment response was defined as a ≥10% increase in partial pressure of arterial oxygen (PaO) or a ≥10% decrease in oxygenation index (OI) after initiation of study gas without the need for extracorporeal membrane oxygenation (ECMO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1368-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330425PMC
January 2019
2 Reads
1.918 Impact Factor

Genetic investigation confirmed the clinical phenotype of congenital chloride diarrhea in a Hungarian patient: a case report.

BMC Pediatr 2019 Jan 11;19(1):16. Epub 2019 Jan 11.

Department of Medical Genetics, University of Szeged, Szeged, Hungary.

Background: Congenital chloride diarrhea (CCD, OMIM 214700) is a rare autosomal recessively inherited condition characterized by watery diarrhea, hypochloremia and metabolic alkalosis. Mutations of the solute carrier family 26, member 3 (SLC26A3, OMIM 126650) gene are responsible for the disease. The gene encodes a transmembrane protein, which is essential for intestinal chloride absorption. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-019-1390-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330408PMC
January 2019
8 Reads

The effect of placebo on endurance capacity in normal weight children - a randomized trial.

BMC Pediatr 2019 Jan 10;19(1):15. Epub 2019 Jan 10.

Pediatric Department, Child Health Sport Center, Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: The aim of the study was to examine the influence of the placebo effect on the endurance capacity results in normal weight children.

Methods: Twenty-four pre-pubertal normal-weight children aged 6-13 years participated in the study. Subjects underwent anthropometric measurements (weight, height, BMI percentile, and fat percentage), a progressive treadmill exercise test to evaluate endurance capacity, and filled habitual activity questionnaire. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-019-1394-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327389PMC
January 2019
6 Reads

Ultrasound of the infant hip: manual fixation is equivalent to Graf's technique regarding image quality-a randomized trial.

BMC Pediatr 2019 Jan 10;19(1):14. Epub 2019 Jan 10.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Background: In Middle Europe ultrasonography is the standard method used to screen for developmental dysplasia of the hip in infants. Our aim was to determine whether manual fixation of the child is equivalent to Graf's technique regarding image quality.

Methods: This randomized trial was conducted at a free-standing general pediatric outpatient clinic in Vienna, Austria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-019-1392-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327546PMC
January 2019
8 Reads

Physical activity for children with chronic disease; a narrative review and practical applications.

BMC Pediatr 2019 Jan 8;19(1):12. Epub 2019 Jan 8.

Translational Medicine, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 10th floor, 686 Bay St., Toronto, ON, M5G 0A4, Canada.

Background: Physical activity (PA) is associated with a diverse range of health benefits. International guidelines suggest that children should be participating in a minimum of 60 min of moderate to vigorous intensity PA per day to achieve these benefits. However, current guidelines are intended for healthy children, and thus may not be applicable to children with a chronic disease. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-018-1377-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325687PMC
January 2019
10 Reads

Combination therapy with erythropoietin, magnesium sulfate and hypothermia for hypoxic-ischemic encephalopathy: an open-label pilot study to assess the safety and feasibility.

BMC Pediatr 2019 Jan 8;19(1):13. Epub 2019 Jan 8.

Department of Neonatology, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka, 534-0021, Japan.

Background: Although therapeutic hypothermia improves the outcome of neonatal hypoxic-ischemic encephalopathy (HIE), its efficacy is still limited. This preliminary study evaluates the safety and feasibility of the combination therapy with erythropoietin (Epo), magnesium sulfate and hypothermia in neonates with HIE.

Methods: A combination therapy with Epo (300 U/kg every other day for 2 weeks), magnesium sulfate (250 mg/kg for 3 days) and hypothermia was started within 6 h of birth in neonates who met the institutional criteria for hypothermia therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1389-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325796PMC
January 2019
2 Reads

Protocol for a transdiagnostic study of children with problems of attention, learning and memory (CALM).

BMC Pediatr 2019 Jan 8;19(1):10. Epub 2019 Jan 8.

MRC Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB2 7EF, England.

Background: A substantial proportion of the school-age population experience cognitive-related learning difficulties. Not all children who struggle at school receive a diagnosis, yet their problems are sufficient to warrant additional support. Understanding the causes of learning difficulties is the key to developing effective prevention and intervention strategies for struggling learners. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-018-1385-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328007PMC
January 2019
11 Reads

Evaluation of systemic inflammatory response syndrome-negative sepsis from a Chinese regional pediatric network.

BMC Pediatr 2019 Jan 8;19(1):11. Epub 2019 Jan 8.

Departments of Pediatrics and Pediatric Critical Care, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Background: The identification of sepsis in children varies depending on the definition used. Our purpose was to compare clinical data and outcome of atypical sepsis, manifested as having sepsis but not fulfilling the criteria of systemic inflammatory response syndrome (SIRS-negative sepsis, SNS), in children based on the modified Angus criteria with those of sepsis (S) and severe sepsis (SS) based on the international consensus criteria.

Methods: Pediatric departments in 11 regional city and county referral hospitals with emergency and intensive care settings in Huai'an serving for 843,000 children participated in a parallel multicenter prospective survey. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-018-1364-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325779PMC
January 2019
9 Reads