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    Semi-automated quantification of hard exudates in colour fundus photographs diagnosed with diabetic retinopathy.
    BMC Ophthalmol 2017 Sep 20;17(1):172. Epub 2017 Sep 20.
    Smt. Kanuri Santhamma Retina Vitreous Centre, L.V.Prasad Eye Institute, Hyderabad, 500034, India.
    Background: Hard exudates (HEs) are the classical sign of diabetic retinopathy (DR) which is one of the leading causes of blindness, especially in developing countries. Accordingly, disease screening involves examining HEs qualitatively using fundus camera. However, for monitoring the treatment response, quantification of HEs becomes crucial and hence clinicians now seek to measure the area of HEs in the digital colour fundus (CF) photographs. Read More

    Ocular knowledge and practice among type 2 diabetic patients in a tertiary care hospital in Bangladesh.
    BMC Ophthalmol 2017 Sep 19;17(1):171. Epub 2017 Sep 19.
    Department of Biostatistics, Bangladesh University of Health Sciences, 125/1, Darus Salam, Mirpur-1, Dhaka, Bangladesh.
    Background And Aims: Diabetes mellitus is likely to have a major effect on vision, and adequate knowledge of its ocular manifestations is of substantial importance to diabetic patients. The study aimed to assess the ocular knowledge and practices among Type 2 diabetic patients of Bangladesh.

    Methods: This cross-sectional study included 122 diabetic patients from the outpatient department (OPD) of the apex diabetic healthcare hospital of the country under the sponsorship of the Diabetic Association of Bangladesh (BIRDEM). Read More

    Evaluation of preoperative speed of progression and its association with surgical outcomes in primary congenital glaucoma patients: a retrospective study.
    BMC Ophthalmol 2017 Sep 18;17(1):170. Epub 2017 Sep 18.
    Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, People's Republic of China.
    Background: Surgeries are inevitable for treating primary congenital glaucoma (PCG) and risk factors of surgical failure play a key role in surgical decision making. The aim of this study was to investigate the influence of delay of surgery and preoperative speed of progression (SP) on the surgical outcomes in these patients.

    Methods: Medical records of 83 eyes of 51 PCG patients with trabeculotomy within 3 years were retrospectively observed. Read More

    Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography.
    BMC Ophthalmol 2017 Sep 15;17(1):167. Epub 2017 Sep 15.
    Yaoeda Eye Clinic, 2-1649-1 Naga-Chou, Nagaoka, Niigata, 940-0053, Japan.
    Background: To investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT).

    Methods: This study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3. Read More

    Descemet membrane detachment in femtosecond laser-assisted cataract surgery: a case report.
    BMC Ophthalmol 2017 Sep 16;17(1):169. Epub 2017 Sep 16.
    Eye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
    Background: Femtosecond laser-assisted cataract surgery (FLACS) has grown in popularity among ophthalmologists as a novel technique. However, descemet membrane detachment (DMD) began to be found as the complication after FLACS. We report a case of serious DMD following FLACS due to the inappropriate incision design. Read More

    Analysis of various factors affecting pupil size in patients with glaucoma.
    BMC Ophthalmol 2017 Sep 16;17(1):168. Epub 2017 Sep 16.
    Department of ophthalmology, College of Medicine, Dankook University, 119, Dandae-ro, Dnognam-gu, Cheonan-si, Chungnam, 31119, Republic of Korea.
    Background: Pupil size is an important factor in predicting post-operative satisfaction. We assessed the correlation between pupil size, measured by Humphrey static perimetry, and various affecting factors in patients with glaucoma.

    Methods: In total, 825 eyes of 415 patients were evaluated retrospectively. Read More

    Internal limiting membrane peeling and gas tamponade for myopic foveoschisis: a systematic review and meta-analysis.
    BMC Ophthalmol 2017 Sep 8;17(1):166. Epub 2017 Sep 8.
    Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road., Xi-Cheng District, Beijing, 100050, China.
    Background: Myopic foveoschisis (MF) is among the leading causes of visual loss in high myopia. However, it remains controversial whether internal limiting membrane (ILM) peeling or gas tamponade is necessary treatment option for MF.

    Methods: PubMed, EMBASE, CBM, CNKI, WANFANG DATA and VIP databases were systematically reviewed. Read More

    Plasma metabolomic study in Chinese patients with wet age-related macular degeneration.
    BMC Ophthalmol 2017 Sep 6;17(1):165. Epub 2017 Sep 6.
    Department of Ophthalmology, China-Japan Friendship Hospital, Yinghua Donglu, Chaoyang District, Beijing, 100029, China.
    Background: Age-related macular degeneration (AMD) is a leading disease associated with blindness. It has a high incidence and complex pathogenesis. We aimed to study the metabolomic characteristics in Chinese patients with wet AMD by analyzing the morning plasma of 20 healthy controls and 20 wet AMD patients for metabolic differences. Read More

    The quality of systematic reviews about interventions for refractive error can be improved: a review of systematic reviews.
    BMC Ophthalmol 2017 Sep 5;17(1):164. Epub 2017 Sep 5.
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
    Background: Systematic reviews should inform American Academy of Ophthalmology (AAO) Preferred Practice Pattern® (PPP) guidelines. The quality of systematic reviews related to the forthcoming Preferred Practice Pattern® guideline (PPP) Refractive Errors & Refractive Surgery is unknown. We sought to identify reliable systematic reviews to assist the AAO Refractive Errors & Refractive Surgery PPP. Read More

    Apln-CreERT:mT/mG reporter mice as a tool for sprouting angiogenesis study.
    BMC Ophthalmol 2017 Sep 2;17(1):163. Epub 2017 Sep 2.
    Department of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, 197 Ruijin Er Rd, Huangpu District, Shanghai, 200025, China.
    Background: Angiogenesis is defined as a new blood vessel sprouting from pre-existing vessels, and the sprouting angiogenesis is the start phase of angiogenesis, which is critical for both physiological and pathological processes, such as embryonic development, organ growth, wound healing, tumor growth, diabetic retinopathy and age-related macular degeneration. Better understanding of the mechanisms of sprout angiogenesis will provide a rationale for the treatments of these angiogenesis related diseases.

    Methods: mT/mG tool mice are crossed with Apln-CreERT mice to generate Apln-CreERT: mT/mG mice, then we used neonatal retinal angiogenesis model to observe the angiogenic pattern of Apln-CreERT:mT/mG mice compared with Cdh5-CreERT:mT/mG mice. Read More

    Prevalence, pattern and risk factors of retinal vein occlusion in an elderly population in Nepal: the Bhaktapur retina study.
    BMC Ophthalmol 2017 Sep 2;17(1):162. Epub 2017 Sep 2.
    Vrije University Medical Center, Amsterdam, The Netherlands.
    Background: This study aims to explore the prevalence, pattern and risk factors of retinal vein occlusion (RVO) in an elderly population of Nepal.

    Method: One thousand eight hundred sixty subjects of age 60 years and above were enrolled in a population-based, cross-sectional study. Detailed history, visual acuity, anterior segment and posterior segment examinations were done. Read More

    Portable OCT-assisted surgical treatment of intracorneal pre-Descemet epithelial cyst: a case report.
    BMC Ophthalmol 2017 Aug 29;17(1):160. Epub 2017 Aug 29.
    Department of Ophthalmology, Corneal Dystrophy Research Institute, Institute of Vision Research, Severance Biomedical Science Institute, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, Seoul, 120-752, South Korea.
    Background: Intracorneal epithelial cysts are a rare clinical condition that can occur anywhere in the corneal tissue; however, they appear most commonly in the stroma. They are sometimes challenging to treat because of their location, depth, and visual outcomes. Herein, we report a pre-Descemet epithelial cyst that was successfully treated surgically, with guidance from Fourier-domain optical coherence tomography (FD-OCT). Read More

    Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration.
    BMC Ophthalmol 2017 Aug 29;17(1):161. Epub 2017 Aug 29.
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Background: Lutein and zeaxanthin are suggested micronutrient supplements to prevent the progression of age-related macular degeneration (AMD), a leading cause of blindness worldwide. To monitor the levels of lutein/zeaxanthin in the macula, macular pigment optical density (MPOD) is measured. A commercially available device (MPSII®, Elektron Technology, Switzerland), using technology based on heterochromatic flicker photometry, can measure both absolute and estimated values of MPOD. Read More

    Combined Brown syndrome and superior oblique palsy without a trochlear nerve: case report.
    BMC Ophthalmol 2017 Aug 25;17(1):159. Epub 2017 Aug 25.
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166, Gumiro, Bundang-gu, Seongnam, Gyeonggi-do, 463-707, South Korea.
    Background: Congenital Brown syndrome is characterized by limited elevation particularly during adduction. The pathogenesis of congenital Brown syndrome is still controversial.

    Case Presentation: A 6-year-old boy had been tilting his head to the left since infancy. Read More

    Comparison of 12-month therapeutic effect of conbercept and ranibizumab for diabetic macular edema: a real-life clinical practice study.
    BMC Ophthalmol 2017 Aug 25;17(1):158. Epub 2017 Aug 25.
    Department of Ophthalmology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, 200065, China.
    Background: To compare the efficacy of intravitreal conbercept and ranibizumab in the treatment of diabetic macular edema (DME) in a real-life clinical practice.

    Methods: This was a retrospective study. Among 62 Chinese patients with DME, 32 patients (36 eyes) received intravitreal conbercept (IVC) injections and 30 patients (32 eyes) received intravitreal ranibizumab (IVR) injections, once a month for 3 months followed by as needed therapy. Read More

    Applying next generation sequencing with microdroplet PCR to determine the disease-causing mutations in retinal dystrophies.
    BMC Ophthalmol 2017 Aug 24;17(1):157. Epub 2017 Aug 24.
    Intramural IT and Bioinformatics Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
    Background: Inherited Retinal dystrophy (IRD) is a broad group of inherited retinal disorders with heterogeneous genotypes and phenotypes. Next generation sequencing (NGS) methods have been broadly applied for analyzing patients with IRD. Here we report a novel approach to enrich the target gene panel by microdroplet PCR. Read More

    Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis.
    BMC Ophthalmol 2017 Aug 24;17(1):155. Epub 2017 Aug 24.
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Many patients who suffer unilateral non-arteritic anterior ischemic optic neuropathy (NAION) will eventually develop the same condition in their other eye, worrying them about losing vision in both eyes. The purpose of this meta-analysis is to determine whether it is possible to predict the visual outcome of the consecutive NAION event based on initial presentation and to compare mean visual loss of firstly versus secondly affected eyes.

    Methods: A systematic review and meta-analysis of studies published between January 1st 1966 and May 31st 2016 reporting on visual acuity and/or visual field loss of both affected eyes, measured either at presentation or follow-up following bilateral NAION. Read More

    Comparison of astigmatism prediction error taken with the Pentacam measurements, Baylor nomogram, and Barrett formula for toric intraocular lens implantation.
    BMC Ophthalmol 2017 Aug 24;17(1):156. Epub 2017 Aug 24.
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, #81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
    Background: To evaluate and compare the astigmatism prediction errors taken with the Pentacam measurements, Baylor nomogram, and Barrett formula for toric intraocular lens (IOL) implantation.

    Methods: Phacoemulsification with toric Precizon IOL implantation was performed in 41 eyes with corneal astigmatism (range, 1 to 5 diopters (D)) determined by IOLMaster and SimK on Pentacam. Preoperative corneal astigmatism measurements were obtained from IOLMaster readings (IOLMaster, Baylor-IOLMaster, and Barrett-IOLMaster) and Pentacam readings (SimK, Baylor-SimK, Barrett-SimK, wavefront, true net power, total corneal refractive power, and vector derived by manual vector summation using corneal front and back astigmatism). Read More

    Awareness and knowledge of glaucoma and associated factors among adults: a cross sectional study in Gondar Town, Northwest Ethiopia.
    BMC Ophthalmol 2017 Aug 24;17(1):154. Epub 2017 Aug 24.
    Department of Optometry, College of Medicine and Health Sciences, University of Gondar, P.O. BOX: 196, Gondar, Ethiopia.
    Background: Raising public awareness and knowledge about glaucoma is a key for early case identification and prevention of blindness. However, awareness and knowledge about glaucoma is unknown at community level, making provision of interventions difficult. This study was intended to assess the awareness and knowledge of adults about glaucoma and the factors affecting it in Gondar town, Northwest Ethiopia. Read More

    The association between socioeconomic status and visual impairments among primary glaucoma: the results from Nationwide Korean National Health Insurance Cohort from 2004 to 2013.
    BMC Ophthalmol 2017 Aug 23;17(1):153. Epub 2017 Aug 23.
    Institute of Health Services Research, Department of Preventive Medicine, College of Medicine, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
    Background: Glaucoma is one of the most leading causes of permanent visual impairments in Korea, and social expenses spent for the glaucoma are increasing. This study is to identify association between socioeconomic status and the visual impairments caused by primary glaucoma in Korea.

    Methods: This study is based on a cohort study using stratified representative samples in the National Health Insurance claim data from 2002 to 2013 with 1,025,340 representative subjects. Read More

    Intraocular lens power calculation using standard formulas and ray tracing after DMEK in patients with Fuchs endothelial dystrophy.
    BMC Ophthalmol 2017 Aug 23;17(1):152. Epub 2017 Aug 23.
    Department of Ophthalmology, University of Münster Medical Center, Albert-Schweitzer-Campus 1, Building D15, 48149, Muenster, Germany.
    Background: The study presented here aims to optimize the accuracy of intraocular lens (IOL) power calculations in patients after DMEK by evaluation of the impact of the altered anterior/posterior corneal curvature relationship.

    Methods: Scheimpflug-based Oculus Pentacam imaging was performed after DMEK surgery for Fuchs endothelial dystrophy. The IOL power was calculated for all patients by ray tracing, aiming for postoperative emmetropia. Read More

    Bacterial pathogens associated with external ocular infections alongside eminent proportion of multidrug resistant isolates at the University of Gondar Hospital, northwest Ethiopia.
    BMC Ophthalmol 2017 Aug 22;17(1):151. Epub 2017 Aug 22.
    Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences (CMHS), University of Gondar (UOG), P.O. box 196, Gondar, Ethiopia.
    Background: External ocular infection is a public health problem in Ethiopia. The aim of this study was to determine the prevalence and antimicrobial susceptibility pattern of external ocular bacterial infections.

    Methods: A cross sectional study was conducted at the University of Gondar Hospital among patients seeking health services at the Department of Ophthalmology from January to April, 2016. Read More

    Visual function improvement using photocromic and selective blue-violet light filtering spectacle lenses in patients affected by retinal diseases.
    BMC Ophthalmol 2017 Aug 22;17(1):149. Epub 2017 Aug 22.
    Department of Ophthalmology, San Paolo Hospital, University of Milan, Milan, Italy.
    Background: To evaluate functional visual parameters using photocromic and selective blue-violet light filtering spectacle lenses in patients affected by central or peripheral scotoma due to retinal diseases. Sixty patients were enrolled in this study: 30 patients affected by central scotoma, group 1, and 30 affected by peripheral scotoma, group 2. Black on White Best Corrected Visual Acuity (BW-BCVA), White on Black Best Corrected Visual Acuity (WB-BCVA), Mars Contrast Sensitivity (CS) and a Glare Test (GT) were performed to all patients. Read More

    Hydrophilic intraocular lens opacification after posterior lamellar keratoplasty - a material analysis with special reference to optical quality assessment.
    BMC Ophthalmol 2017 Aug 22;17(1):150. Epub 2017 Aug 22.
    International Vision Correction Research Centre and the David J. Apple International Laboratory for Ocular Pathology, Department of Ophthalmology, University of Heidelberg, INF 400, 69120, Heidelberg, Germany.
    Background: Laboratory analysis and optical quality assessment of explanted hydrophilic intraocular lenses (IOLs) with clinically significant opacification after posterior lamellar keratoplasty (DMEK and DSAEK).

    Methods: Thirteen opacified IOLs after posterior lamellar keratoplasty, 8 after descemet stripping automated endothelial keratoplasty (DSAEK), 3 after descemet membrane endothelial keratoplasty (DMEK) and 2 after both DSAEK and DMEK were analysed in our laboratory. Analyses included optical bench assessment for optical quality, light microscopy, scanning electron microscopy (SEM) and energy dispersive X-Ray spectroscopy (EDS). Read More

    Dislocation of a previously successful XEN glaucoma implant into the anterior chamber: a case report.
    BMC Ophthalmol 2017 Aug 22;17(1):148. Epub 2017 Aug 22.
    Sussex Eye Hospital, Brighton, UK.
    Background: XEN glaucoma implant (XEN gel stent, Aquesys, Inc) is a new minimally invasive device approved for the treatment of glaucoma.

    Case Presentation: A 45 year old female was being followed and treated for primary open angle glaucoma in our tertiary referral center. Due to failure of medical treatment in controlling the glaucoma, surgery was offered to the patient. Read More

    Predictive models of long-term anatomic outcome in age-related macular degeneration treated with as-needed Ranibizumab.
    BMC Ophthalmol 2017 Aug 18;17(1):147. Epub 2017 Aug 18.
    Instituto de Oftalmobiologia Aplicada (IOBA), Campus Miguel Delibes, University of Valladolid, P° de Belén n° 17, 47011, Valladolid, Spain.
    Background: To analyze predictors and develop predictive models of anatomic outcome in neovascular age-related macular degeneration (AMD) treated with as-needed ranibizumab after 4 years of follow-up.

    Methods: A multicenter consecutive case series non-interventional study was performed. Clinical, funduscopic and OCT characteristics of 194 treatment-naïve patients with AMD treated with as-needed ranibizumab for at least 2 years and up to 4 years were analyzed at baseline, 3 months and each year until the end of the follow-up. Read More

    Ocular toxicity due to Trametinib and Dabrafenib.
    BMC Ophthalmol 2017 Aug 17;17(1):146. Epub 2017 Aug 17.
    General Hospital Klagenfurt, Department of Opthalmology, Feschnigstraße 11, A-9020, Klagenfurt, Austria.
    Background: To report a case of uveitis and neuroretinal detachment in a patient treated with Trametinib and Dabrafenib due to metastatic cutaneous melanoma stage IV.

    Case Presentation: We evaluated slit lamp examination, fundoscopy, optical coherence tomography, fluorescein and indocyanine green angiography in a 66 years old man suffering visual loss. Fundoscopy showed serous neuroretinal detachment of the fovea accompanied with white spots surrounding the fovea in both eyes. Read More

    Early onset coats' disease initially treated as unilateral ROP at 39 weeks postmenstrual age: a case report.
    BMC Ophthalmol 2017 Aug 16;17(1):145. Epub 2017 Aug 16.
    Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
    Background: This is the youngest case of Coats' disease, in terms of postmenstrual age (PMA), to be reported in the literature. This case highlights the remarkable variations in the clinical manifestations and the very early onset of Coats' disease. This case is unusual in both the age of onset and atypical clinical features, which resemble retinopathy of prematurity (ROP). Read More

    MiRNAs regulate oxidative stress related genes via binding to the 3' UTR and TATA-box regions: a new hypothesis for cataract pathogenesis.
    BMC Ophthalmol 2017 Aug 14;17(1):142. Epub 2017 Aug 14.
    Basic Research Center, Affiliated Shaanxi Provincial Tumor Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, China.
    Background: Age-related cataracts are related to oxidative stress. However, the genome-wide screening of cataract related oxidative stress related genes are not thoroughly investigated. Our study aims to identify cataract regulated miRNA target genes that are related to oxidative stress and to propose a new possible mechanism for cataract formation. Read More

    Case report of ocular Kaposi's sarcoma.
    BMC Ophthalmol 2017 Aug 14;17(1):143. Epub 2017 Aug 14.
    The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at Sun Yat-sen University, #54 Xian lie South Road, Guangzhou, 510060, China.
    Background: Kaposi's sarcoma (KS) is generally considered a neoplastic disorder of vascular origin and occurs in patients with acquired immunodeficiency syndrome (AIDS) or who have received immunosuppressive treatments after an organ transplant (Soulier et al., Blood 86(4):1276-80, 1995; Viejo-Borbolla and Schulz, AIDS Rev 5(4):222-9, 2003; Schulz, J Antimicrob Chemother 45(Suppl T3):15-27, 2000; Aversa et al. Crit Rev Oncol Hematol 53(3):253-65, 2005; Mbulaiteye and Engels, Int J Cancer 119(11):2685-91, 2006; Tessari et al. Read More

    Cystoid macular oedema associated with Rosai-Dorfman disease: a case report.
    BMC Ophthalmol 2017 Aug 14;17(1):141. Epub 2017 Aug 14.
    Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
    Background: The aim of this study is to report a case of cystoid macular oedema (CME) associated with Rosai-Dorfman Disease (RDD).

    Case Presentation: A 52-year-old male initially presented with a two-month history of a congested left eye. At presentation, visual acuity was 20/20 in the right eye and 20/80 in the left eye. Read More

    Changes in macular sensitivity after half-dose photodynamic therapy for chronic central serous chorioretinopathy.
    BMC Ophthalmol 2017 Aug 10;17(1):140. Epub 2017 Aug 10.
    Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650031, China.
    Background: To evaluate the macular sensitivity changes after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR).

    Methods: Eighteen patients (26 eyes) with chronic CSCR were recruited in the same hospital between April 2011 and December 2012. All patients were treated with one session of half-dose PDT after complete ophthalmic examination. Read More

    Patients' preferences for involvement in the decision-making process for treating diabetic retinopathy.
    BMC Ophthalmol 2017 Aug 9;17(1):139. Epub 2017 Aug 9.
    Center for Ophthalmology, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
    Background: To assess factors associated with the preferred role of the attending ophthalmologist in the decision-making processes before treating diabetic retinopathy (DR).

    Methods: Cross-sectional study of 810 adults attending secondary diabetes care centers (NCT02311504). Diabetes patients were classified using a validated questionnaire in an ophthalmologist-dominant decision-making (ODM), shared decision-making (SDM) and patient-dominant decision-making (PDM) style. Read More

    Endoscopic dacryocystorhinostomy with an otologic T-type ventilation tube in repeated revision cases.
    BMC Ophthalmol 2017 Aug 7;17(1):138. Epub 2017 Aug 7.
    Department of Otorhinolarynogology, The Second People's Hospital of Wuxi, Nanjing Medical University, NO. 68, Zhongshan Road Wuxi, Nanjing, Jiangsu, 214002, China.
    Background: To compare the frequency of appearance of complications, anatomical success and functional success after conventional endoscopic dacryocystorhinostomies (EN-DCRs) or EN-DCR with otologic T-Type ventilation tube combined with silicone tube intubation in repeated revision cases.

    Methods: Twenty-two patients who had epiphora and recurrent dacryocystitis after at least a previous failed revision DCR as well as 22 patients receiving conventional EN-DCR only were enrolled in the study between January 2008 and December 2011. Operations were performed by using an otologic T-tube combined with silicone tube intubation. Read More

    Acute uveal effusion during phacoemulsification with preoperative central serous chorioretinopathy: a case report.
    BMC Ophthalmol 2017 Aug 3;17(1):137. Epub 2017 Aug 3.
    Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
    Background: We report a case of acute uveal effusion during phacoemulsification in an eye with preoperative chronic central serous chorioretinopathy (CSC).

    Case Presentation: A 55-year-old man with a history of chronic CSC for >18 months presented with bilateral opaque lenses. A preoperative ophthalmic examination showed suspected lenticonus and risky anatomical features, including a thick ciliary body, and anterior rotation of the ciliary process and iris root in both eyes. Read More

    Long term safety and tolerability of Tafluprost 0.0015% vs Timolol 0.1% preservative-free in ocular hypertensive and in primary open-angle glaucoma patients: a cross sectional study.
    BMC Ophthalmol 2017 Aug 3;17(1):136. Epub 2017 Aug 3.
    Eye Clinic, Department of Surgical Sciences, University of Torino, Via Juvarra 19, 10122, Torino, Italy.
    Background: The effects of preservatives of antiglaucoma medications on corneal surface and tear function have been widely shown in literature; it's not the same as regards the active compounds themselves. The purpose of our study was to compare Ocular Surface Disease (OSD) signs and symptoms of Tafluprost 0.0015% versus preservative free (PF) Timolol 0. Read More

    Notch1 signaling induces epithelial-mesenchymal transition in lens epithelium cells during hypoxia.
    BMC Ophthalmol 2017 Aug 1;17(1):135. Epub 2017 Aug 1.
    Department of Ophthalmology, Shengjing Hospital, China Medical University, NO.36 Sanhao Street, Shenyang City, Liaoning Province, 110004, China.
    Background: Posterior Capsular Opacification (PCO) is one of the most common complications of cataract surgery which can result in severe visual damage. Epithelial-Mesenchymal Transition (EMT) of lens epithelium cells (LEC) is the pathological basis of PCO. Recent research showed that hypoxia acted as an inducer of EMT through a Notch1/Snail1/E-cadherin pathway. Read More

    Intraoperative optical coherence tomography assisted analysis of pars Plana vitrectomy for retinal detachment in morning glory syndrome: a case report.
    BMC Ophthalmol 2017 Aug 1;17(1):134. Epub 2017 Aug 1.
    Department of Ophthalmology, Rudolf Foundation Clinic, Juchgasse 25, A-1030, Vienna, Austria.
    Background: The pathogenesis of non-rhegmatogenous retinal detachment (non-RRD) associated with morning glory syndrome (MGS) is not established, as well as best surgical approach to treat RD. Our purpose was to analyse intraoperative optical coherence tomography data (iOCT) in all steps of pars plana vitrectomy (PPV) for non-RRD in MGS, in order to follow pathophysiological aspects of the disease and to understand the tissues behaviour during surgical workflow.

    Case Presentation: Intraoperative spectral domain optical coherent tomography (iSD-OCT) assisted PPV using Rescan 700 (Carl Zeiss Meditech, Jena, Germany) with epiretinal membrane (ERM) and internal retinal membrane (ILM) peeling, and air endotamponade was performed on the only eye of a 21 years old female with non-RRD associated with MGS. Read More

    Association of alpha A-crystallin polymorphisms with susceptibility to nuclear age-related cataract in a Han Chinese population.
    BMC Ophthalmol 2017 Jul 29;17(1):133. Epub 2017 Jul 29.
    Department of Ophthalmology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China.
    Background: Alpha A-crystallin (CRYAA) is considered critical for the maintenance of lens transparency and is related to the pathogenesis of age-related cataracts (ARCs), especially the nuclear subtype. As the 5' untranslated region (5' UTR) modulates gene expression, the purpose of current study was to investigate whether single nucleotide polymorphisms (SNPs) in the 5' UTR of CRYAA were associated with susceptibility to ARC in a Han Chinese population and to clarify the mechanism of this association.

    Methods: SNPs in the 5' UTR (-1 to -1000) of CRYAA were identified in 243 nuclear ARC patients and 263 controls using polymerase chain reaction and DNA sequencing. Read More

    Conjunctival lymphoma during pregnancy: a case report.
    BMC Ophthalmol 2017 Jul 27;17(1):131. Epub 2017 Jul 27.
    Department of Ophthalmology, Chang Gung Memorial Hospital and University, #5, Fu-Hsing Street, Kweishan, Taoyuan, 333, Taiwan.
    Background: To present a case of conjunctival lymphoma in a young woman complicated by pregnancy.

    Case Presentation: A 38-year-old previously healthy woman presented with a 2-year history of progressive right blepharoptosis. Giant papillomatous sessile masses were identified in the upper and lower fornix bilaterally and involved the tarsus of the right upper lid. Read More

    Clinical efficacy of implantation of toric intraocular lenses with different incision positions: a comparative study of steep-axis incision and non-steep-axis incision.
    BMC Ophthalmol 2017 Jul 27;17(1):132. Epub 2017 Jul 27.
    Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China.
    Background: To compare the clinical outcomes after implantation of AcrySof Toric IOLs with different clear corneal incisions.

    Methods: Sixty cataract patients with regular corneal astigmatism who underwent phacoemulsification combined with implantation of an AcrySof Toric IOL were enrolled. They were divided into two groups according to the position of the clear corneal incision: steep-axis and non-steep-axis. Read More

    Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model.
    BMC Ophthalmol 2017 Jul 24;17(1):129. Epub 2017 Jul 24.
    Faculty of Veterinary, Department of Animal Nutrition, Firat University, Elazig, Turkey.
    Background: Several studies associated high-fat intakes with a high incidence of age-related macular degeneration (AMD). Lutein and Zeaxanthin isomers (L/Zi) may counteract reactive oxygen species produced by oxidative stress. The present study was conducted to determine the possible effects of L/Zi administration on lipid profile, protein genes associated with oxidative stress and inflammation pathways in the obesity induced by a high-fat diet (HFD) in rodents. Read More

    Outcomes after the surgery for acquired nonaccommodative esotropia.
    BMC Ophthalmol 2017 Jul 24;17(1):130. Epub 2017 Jul 24.
    Department of Ophthalmology, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Shingil-ro 1, Youngdeungpo-gu, Seoul, 07441, South Korea.
    Background: To analyze the surgical outcomes for patients diagnosed with acquired nonaccommodative esotropia (ANAET).

    Methods: In this retrospective study, the medical records of 35 patients who had undergone the surgery for ANAET with a postoperative follow-up period of 6 months or more were reviewed. The main outcome measures were postoperative esodeviation angle, final success rate, and factors affecting surgical outcome. Read More

    Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report.
    BMC Ophthalmol 2017 Jul 19;17(1):128. Epub 2017 Jul 19.
    Department of Ophthalmology, National Defense Medical College, 3-2 Namiki, Tokorozawa City, Saitama, 359-8513, Japan.
    Background: Coxsackieviruses are members of a group of viruses called the enteroviruses, which may cause respiratory and gastrointestinal symptoms, erythema, meningoencephalitis, myocarditis, pericarditis, and myositis. Unilateral acute idiopathic maculopathy caused by coxsackievirus A16 has been associated with hand, foot, and mouth disease, but only a few reports describe retinitis associated with coxsackievirus serotype B3 or B4. We report a case of bilateral multifocal obstructive retinal vasculitis that developed after coxsackievirus A4 infection. Read More

    Visumax femtolasik versus Moria M2 microkeratome in mild to moderate myopia: efficacy, safety, predictability, aberrometric changes and flap thickness predictability.
    BMC Ophthalmol 2017 Jul 17;17(1):125. Epub 2017 Jul 17.
    Department of ophthalmology, Faculty of medicine, Mansoura university, 24 Al-Gomhoria street, Mansoura, Egypt.
    Introduction: This is an interventional prospective clinical study which was conducted to evaluate the efficacy, safety, predictability, ocular aberrations, and flap thickness predictability of Visumax femtosecond laser (FSL) compared to Moria M2 microkeratome (MK) in mild to moderate myopia.

    Methods: This study included 60 eyes who were divided into two groups. Thirty eyes in group (I) in which the flap was created with Visumax FSL, while in group II (30 eyes) the Moria M2 MK was used. Read More

    Periorbital changes associated with prostaglandin analogs in Korean patients.
    BMC Ophthalmol 2017 Jul 17;17(1):126. Epub 2017 Jul 17.
    Department of Ophthalmology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, 896 Pyeongchon-dong, Dongan-gu, Anyang, Gyeonggi-do, 431-070, South Korea.
    Background: Prostaglandin analogs (PGAs) are commonly used to treat glaucoma because of their powerful intraocular pressure lowering effect. However, various periorbital changes associated with the use of PGAs have been reported. We investigated the incidence of periorbital changes in Korean patients who were treated with PGAs, and analyzed clinical factors associated with superior sulcus deepening. Read More

    The peripheral and Central Humphrey visual field - morphological changes during aging.
    BMC Ophthalmol 2017 Jul 17;17(1):127. Epub 2017 Jul 17.
    Department of Anatomy, TU Dresden, Dresden, Germany.
    Background: To define age-related changes in the visual field by comparing 'standard' central and unique peripheral visual field measurements in healthy volunteers.

    Methods: In a single center, retrospective, Cross-sectional, observational study, 20 volunteers with no retinal diseases or risk factors, ranging in age between 30 and 94 years (four age groups: 30's, 50's, 70's, 90's) were measured in one eye (preferentially the right one) using a Humphrey visual field 24-2 and 60-4.

    Results: While the central visual field remained relatively well preserved during aging showing only a mild reduction in sensitivity, a profound loss of the peripheral visual field was observed beginning in the fifth decade of life and decreasing continuously up to the 90ies. Read More

    The effect of oral acetazolamide on cystoid macular edema in hydroxychloroquine retinopathy: a case report.
    BMC Ophthalmol 2017 Jul 12;17(1):124. Epub 2017 Jul 12.
    Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, #17 Haengdang-dong, Seongdong-gu, Seoul, 133-792, South Korea.
    Background: Hydroxychloroquine (HCQ) retinopathy can accompany other retinal complications such as cystoid macular edema (CME), which leads to central visual loss. We report a case of CME with HCQ retinopathy that improved with the use of oral acetazolamide, and discussed the possible mechanisms of CME in HCQ retinopathy using multimodal imaging modalities.

    Case Presentation: A 62-year-old patient with systemic lupus erythematosus (SLE) and HCQ retinopathy developed bilateral CME with visual decline. Read More

    Association of lifestyle and body structure to ocular axial length in Japanese elementary school children.
    BMC Ophthalmol 2017 Jul 12;17(1):123. Epub 2017 Jul 12.
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
    Background: The purpose of this study is to determine whether the lifestyle and body stature are significantly associated with the axial length (AL) of the eyes of Japanese third grade students.

    Methods: A prospective, cross sectional, observational study was performed on 122 third grade students consisting of 61 boys and 61 girls ages 8 to 9 years. The AL, body height, body weight, and body mass index (BMI) were measured. Read More

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