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    Comparison of femtosecond laser-assisted corneal intrastromal xenotransplantation and the allotransplantation in rhesus monkeys.
    BMC Ophthalmol 2017 Nov 9;17(1):202. Epub 2017 Nov 9.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
    Background: In our previous study, we showed that both allogeneic and autogeneic small-incision femtosecond laser-assisted corneal intrastromal transplantation are safe and effective surgeries. However, the results of small-incision femtosecond laser-assisted intrastromal xenotransplantation have not yet been explored. Additionally, we suggest that glycerol-dehydrated corneal lamellae might provide a possible alternative for this xenogenic implantation approach. Read More

    Partially absorbed cataractous lens in the anterior chamber revealing neglected severe ocular contusion: a case report.
    BMC Ophthalmol 2017 Nov 6;17(1):200. Epub 2017 Nov 6.
    Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, PO Box 3851, Messa, Yaoundé, Cameroon.
    Background: Ocular contusion can produce severe lesions, which if not treated appropriately and promptly, can lead to visual impairment. Ocular contusion in childhood may not be reported by children.

    Case Presentation: A 27 year old female presented with a partially absorbed cataractous lens that was dislocated into the anterior chamber of her left eye. Read More

    Effect of primary Phacoviscocanalostomy/ Viscocanalostomy on intraocular pressure of normal tension glaucoma patients: 3-year results.
    BMC Ophthalmol 2017 Nov 6;17(1):201. Epub 2017 Nov 6.
    Stanley Eye Unit, Abergele Hospital, Llanfair Road, Abergele, Conwy, LL22 8DP, UK.
    Background: The objective of this study was to evaluate the efficacy of Viscocanalostomy/Phacoviscocanalostomy (VC/PVC) in lowering intraocular pressure (IOP) in Normal Tension Glaucoma (NTG) patients.

    Methods: Retrospective electronic database review of patients who underwent VC/PVC for NTG between December 2009 and November 2011 at Stanley eye unit in Abergele Hospital. Goldmann applanation tonometry (GAT) was used for all IOP measurements which were taken at the time of listing for surgery and at 1 day, 1 week, 1 month, then 3-monthly up to 1 year, then half-yearly up to 3 years post operatively. Read More

    Serratia marcescens endophthalmitis after pterygium surgery: a case report.
    BMC Ophthalmol 2017 Nov 2;17(1):197. Epub 2017 Nov 2.
    Department of Ophthalmology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 140-743, Korea.
    Background: To report a case of Serratia marcescens endophthalmitis after pterygium surgery using the bare sclera technique with mitomycin C (MMC).

    Case Presentation: A 69-year-old male patient underwent pterygium excision surgery using the bare sclera technique and 0.02% MMC. Read More

    Blue-light filtering alters angiogenic signaling in human retinal pigmented epithelial cells culture model.
    BMC Ophthalmol 2017 Nov 2;17(1):198. Epub 2017 Nov 2.
    Henry C. Witelson Ocular Pathology Laboratory, Pathology Department, McGill University, Montreal, Canada.
    Background: Light exposure and more specifically the spectrum of blue light contribute to the oxidative stress in Age-related macular degeneration (AMD). The purpose of the study was to establish whether blue light filtering could modify proangiogenic signaling produced by retinal pigmented epithelial (RPE) cells under different conditions simulating risk factors for AMD.

    Methods: Three experiments were carried out in order to expose ARPE-19 cells to white light for 48 h with and without blue light-blocking filters (BLF) in different conditions. Read More

    Comparison of intraocular pressure as measured by three different non-contact tonometers and goldmann applanation tonometer for non-glaucomatous subjects.
    BMC Ophthalmol 2017 Nov 2;17(1):199. Epub 2017 Nov 2.
    Department of Ophthalmology, Keimyung University School of Medicine, Dongsan Medical Center, #56, Dalseong-ro, Jung-gu, Daegu, 41931, South Korea.
    Background: To compare the measurement of intraocular pressure (IOP) among the three different non-contact tonometers (NCT) and the Goldmann applanation tonometer (GAT) for non-glaucomatous subjects.

    Methods: In 52 eyes of 52 non-glaucomatous subjects, IOP was measured sequentially with the Canon TX-20P, the Nidek NT-530P, the Topcon CT-1P, and the GAT at the same time. We evaluated the IOP-measurement agreement among the tonometers as well as the factors affecting the measurements. Read More

    Cionni-modified capsular tension ring for surgical repair of cyclodialysis after trabeculectomy: a case report.
    BMC Ophthalmol 2017 Oct 27;17(1):196. Epub 2017 Oct 27.
    Department of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, 83 Fenyang Rd, Shanghai, 20031, China.
    Background: To report a case for repair of cyclodialysis after trabeculectomy with Cionni-modified capsular tension ring.

    Case Presentation: A 64-year-old man who had undergone trabeculectomy of his left eye 3 months earlier visited our clinic owing to blurred vision. His visual acuity was 20/2000 and the intraocular pressure (IOP) was 6 mmHg. Read More

    Hemorrhagic hypopyon as presenting feature of intravascular lymphoma, a case report.
    BMC Ophthalmol 2017 Oct 25;17(1):195. Epub 2017 Oct 25.
    Department of Ophthalmology, Osaka University Medical School, E7, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
    Background: Herpes uveitis has been previously reported to present with hyphema, but hemorrhagic hypopyon is rarely reported as a herpetic uveitis manifestation. We report a case of herpes simplex virus (HSV) presenting with hemorrhagic hypopyon, and speculate on the underlying pathophysiology with relation to an intravascular lymphoma which was subsequently diagnosed as a result.

    Case Presentation: We present a case wherein a 62-year-old Japanese rheumatoid arthritis woman, with HSV uveitis, presented with hemorrhagic hypopyon in the anterior chamber and a fever with photophobia. Read More

    Evaluation of lymphatic vessel dilatations by anterior segment swept-source optical coherence tomography: case report.
    BMC Ophthalmol 2017 Oct 23;17(1):194. Epub 2017 Oct 23.
    Faculty of Medicine Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
    Background: Conjunctival lymphangiectasia is a rare condition presumably caused by the obstruction of lymphatic channels or by an abnormal connection between conjunctival lymphatic and blood vessels. Diagnosis is based on clinical appearance and histology. We report a case of conjunctival lymphangiectasia in which anterior segment optical coherence tomography (OCT) was used to assist the diagnosis and the planning of the biopsy location. Read More

    Intrasession repeatability of ocular anatomical measurements obtained with a multidiagnostic device in healthy eyes.
    BMC Ophthalmol 2017 Oct 18;17(1):193. Epub 2017 Oct 18.
    Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy, University of Alicante, Crta San Vicente del Raspeig s/n 03016, San Vicente del Raspeig, Alicante, Spain.
    Background: To evaluate the intrasession repeatability of anterior chamber depth (ACD), central (CCT) and peripheral corneal thickness (PCT), white-to-white diameter (WTW), and irido-corneal angle (IA) measurements obtained with a multidiagnostic device in healthy eyes.

    Methods: A total of 107 eyes of 107 patients ranging in age from 23 to 65 years were examined with the VX120 system (Visionix-Luneau Technologies). Three consecutive measurements were obtained with this device to assess the intrasession repeatability of ACD, CCT, PCT at different nasal and temporal locations, WTW, and nasal and temporal IA. Read More

    Visual prognosis better in eyes with less severe reduction of visual acuity one year after onset of Leber hereditary optic neuropathy caused by the 11,778 mutation.
    BMC Ophthalmol 2017 Oct 18;17(1):192. Epub 2017 Oct 18.
    Department of Ophthalmology, Keio University School of Medicine, 35 Sninanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Background: Patients with Leber hereditary optic neuropathy (LHON) have a progressive decrease of their visual acuity which can deteriorate to <0.1. Some patients can have a partial recovery of their vision in one or both eyes. Read More

    Prevalence and risk factors for myopia in older adult east Chinese population.
    BMC Ophthalmol 2017 Oct 13;17(1):191. Epub 2017 Oct 13.
    The First Hospital of Jilin University, NO.71 Xinmin Street, Changchun, China.
    Background: To determine the prevalence and associated factors for myopia and high myopia among older population in a rural community in Eastern China.

    Methods: A community-based, cross-sectional survey was conducted in the Weitang town located in Suzhou, an urban metropolis in East China. A total of 5613 Chinese residents aged 60 years and older were invited to complete a questionnaire and participated in a detailed eye examination,including measurements of visual acuity and refractive error using autorefraction and subjective refraction. Read More

    First identification of Gordonia sputi in a post-traumatic endophthalmitis patient - a case report and literatures review.
    BMC Ophthalmol 2017 Oct 11;17(1):190. Epub 2017 Oct 11.
    Ophthalmology Department of SIR RUN RUN SHAW hospital, SIR RUN RUN SHAW Institute of Clinical Medicine of Zhejiang University, #3 Qingchun East Road, Hangzhou, Zhejiang, 310016, People's Republic of China.
    Background: We present a case of post-traumatic endophthalmitis with relatively good prognosis caused by Gordonia sputi, which, to our knowledge is the first case in the literature.

    Case Presentation: A 24 year old man, who underwent an intraocular foreign body extraction half a month before presentation in the left eye, was referred to us complaining of blurred vision and slight pain for 5 days. His first presentation showed moderate intracameral and intravitreous purulent inflammation with a best corrected vision of counting fingers. Read More

    Low recurrence rate of anchored conjunctival rotation flap technique in pterygium surgery.
    BMC Ophthalmol 2017 Oct 10;17(1):187. Epub 2017 Oct 10.
    Department of Ophthalmology, Dongguk University, Ilsan Hospital, 814, Siksadong, Ilsan-dong-gu, Goyang, Kyunggido, 410-773, South Korea.
    Background: To report the recurrence rate for an anchored conjunctival rotation flap technique in primary pterygium surgery.

    Methods: Primary pterygium surgeries performed using anchored conjunctival rotation flap techniques (110 eyes in 110 patients) with a minimum follow-up of 12 months were reviewed. In this technique, a conjunctival flap is rotated to cover the bare sclera and suture-fixated with either 8-0 polyglactin (41 eyes) or 10-0 nylon (69 eyes). Read More

    Mortality in patients treated with intravitreal bevacizumab for age-related macular degeneration.
    BMC Ophthalmol 2017 Oct 10;17(1):189. Epub 2017 Oct 10.
    Central Headquarters, Clalit Health Services, Tel Aviv, Israel.
    Background: The aim of this study is to analyze mortality in patients treated with bevacizumab for wet AMD.

    Methods: We conducted a retrospective case-control study between patients who received intravitreal injections of bevacizumab as the sole treatment for exudative AMD between September 2008 and October 2014 (n = 5385) and age and gender matched controls (n = 10,756). All individuals included in the study were reviewed for sociodemographic data and comorbidities. Read More

    27-gauge and 25-gauge vitrectomy day surgery for idiopathic epiretinal membrane.
    BMC Ophthalmol 2017 Oct 10;17(1):188. Epub 2017 Oct 10.
    Department of Ophthalmology, Nihon University Hospital, 1-6 Surugadai, Kanda, Chiyodaku, Tokyo, 101-8309, Japan.
    Background: This study compared the postoperative outcomes of 27-gauge (G) and 25-G vitrectomy performed for the treatment of idiopathic epiretinal membrane (ERM).

    Methods: The study design was single center, retrospective, interventional case series. Two hundred consecutive eyes that underwent primary vitrectomy for ERM (27-G vitrectomy in 100 eyes and 25-G vitrectomy in 100 eyes) were studied for 6 months. Read More

    Objective and subjective diagnostic parameters in the fellow eye of unilateral keratoconus.
    BMC Ophthalmol 2017 Oct 6;17(1):186. Epub 2017 Oct 6.
    Ophthalmology Center, Faculty of Medicine, Mansoura University, 24 Al-Gomhoria street, Mansoura, Egypt.
    Background: Keratoconus (KC) is usually a bilateral corneal ectatic disease. For significant asymmetric presentation (so called unilateral KC), the fellow eye has the mildest and earliest form of the disease, which is typically called forme fruste keratoconus. The aim of this study was to evaluate the sensitivity and specificity of parameters derived from a Scheimpflug imaging system (Pentacam) as well as the changes in the quality of mesopic vision in the apparently normal fellow eye (forme fruste) to detect the earliest and most sensitive parameters. Read More

    Subretinal echinococcosis: a case report.
    BMC Ophthalmol 2017 Oct 5;17(1):185. Epub 2017 Oct 5.
    Department of Ophthalmology, Peking University First Hospital, Key Laboratory of Vision Loss and Restoration, Ministry of Education, No. 8 Xi Shi Ku Street, Xicheng District, Beijing, 100034, China.
    Background: Echinococcosis is a dangerous zoonotic parasitic disease. Ocular echinococcosis is very rare, especially the hydatid cysts in subretinal space. We present a case of subretinal echinococcosis and management. Read More

    A case of pseudoxanthoma elasticum with proliferative diabetic retinopathy.
    BMC Ophthalmol 2017 Oct 4;17(1):184. Epub 2017 Oct 4.
    Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka, 569-8686, Japan.
    Background: To report the case of a patient with pseudoxanthoma elasticum (PXE) and proliferative diabetic retinopathy (PDR), and discuss the relationship between PXE and diabetic retinopathy (DR).

    Case Presentation: A 47-year-old man with PXE presented with angioid streaks and DR in both eyes, and bilateral panretinal photocoagulation was performed for treatment. Vitrectomy had previously been performed in his right eye for vitreous hemorrhage due to PDR. Read More

    Femtosecond laser-assisted cataract surgery in patients with phakic intraocular lenses and low endothelial cell counts: a case report.
    BMC Ophthalmol 2017 Oct 3;17(1):180. Epub 2017 Oct 3.
    Department of Ophthalmology, Show Chwan Memorial Hospital, No.2, Ln. 530, Sec. 1, Zhongshan Rd., Changhua City, Changhua, 50093, Taiwan.
    Background: Phakic intraocular lens (PIOL) implantation has been used to correct myopia and myopic astigmatism, although corneal decompensation can occur after implantation. Femtosecond laser-assisted cataract surgery (FLACS) has gained in popularity due to its lower postoperative astigmatism and endothelial loss. Herein, we report the use of FLACS in patients who previously received PIOL implantation and have a low corneal endothelial cell count. Read More

    Idiopathic pigmented vitreous cyst without autofluorescence: a case report.
    BMC Ophthalmol 2017 Oct 3;17(1):183. Epub 2017 Oct 3.
    State Key Laboratory of Ophthalmology, Zhongshan Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.
    Background: Vitreous cysts are rare clinical findings and seldom cause visual disturbance. They are generally classified as congenital or acquired and are considered idiopathic when the etiology can not be determined. A previous electron microscopic observation on an idiopathic pigmented vitreous cyst has confirmed its pigment epithelial origin. Read More

    Short-term in vivo morphological changes of amniotic membrane after fibrin glue-assisted pterygium surgery on anterior segment optical coherence tomography: a case presentation.
    BMC Ophthalmol 2017 Oct 3;17(1):181. Epub 2017 Oct 3.
    Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Republic of Korea.
    Background: The evaluations of morphological changes of amniotic membrane (AM), even after successful AM transplantation surgery without complications, may be difficult. Moreover, there was no report regarding morphological changes after fibrin glue-assisted AM transplantation with pterygium excision. Here, we highlight and describe the use of spectral domain optical coherence tomography (OCT) for the evaluation of the morphological features of amniotic membrane (AM) and of associated in vivo structural changes after fibrin glue-assisted pterygium surgery. Read More

    Quantitative evaluation of hard exudates in diabetic macular edema after short-term intravitreal triamcinolone, dexamethasone implant or bevacizumab injections.
    BMC Ophthalmol 2017 Oct 3;17(1):182. Epub 2017 Oct 3.
    Department of Ophthalmology, Hanyang University College of Medicine, Seoul, South Korea.
    Background: To quantitatively compare short-term hard exudates (HEs) alteration in patients with diabetic macular edema (DME) after intravitreal triamcinolone, dexamethasone implant or bevacizumab injections.

    Methods: This retrospective study enrolled DME eyes with HEs that underwent a single-dose intravitreal injection of triamcinolone (25 eyes), dexamethasone implant (20 eyes), or three monthly injections of bevacizumab (25 eyes) and completed at least three months of follow-up. All patients were examined before and after 1, 2 and 3 months of injections. Read More

    Development and validation of a questionnaire assessing the quality of life impact of Colour Blindness (CBQoL).
    BMC Ophthalmol 2017 Oct 2;17(1):179. Epub 2017 Oct 2.
    Department of Ophthalmology, Queen Elizabeth Hospital Birmingham, Birmingham, B15 2WB, UK.
    Background: Congenital colour vision deficiency (CVD), commonly called 'colour blindness', affects around 8% of men and 0.4% of women. Although many aspects of health (e. Read More

    Assessment of biomarkers using multiplex assays in aqueous humor of patients with diabetic retinopathy.
    BMC Ophthalmol 2017 Oct 2;17(1):176. Epub 2017 Oct 2.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
    Background: With the high prevalence of type 2 diabetes, diabetic retinopathy (DR) has become a leading health problem worldwide. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. The purpose of this study was to assess the levels of immune and inflammatory biomarkers in the aqueous humor of patients with different severities of DR and to analyze the correlations between Interleukin-6 (IL-6) and these biomarkers, and between IL-6 and the severity of the disease. Read More

    Public awareness of common eye diseases in Jordan.
    BMC Ophthalmol 2017 Oct 2;17(1):177. Epub 2017 Oct 2.
    Faculty of Medicine, Department of Public Health, Jordan University of Science and Technology, Irbid, Jordan.
    Background: Cataract, glaucoma, diabetic retinopathy and dry eye disease are common with high prevalence in Jordan. This study aims to assess the awareness of these ocular diseases among Jordanian population.

    Method: A self-designed questionnaire was developed in Arabic and used to interview people in different provinces of Jordan. Read More

    Willingness to donate eyes and its associated factors among adults in Gondar town, North West Ethiopia.
    BMC Ophthalmol 2017 Oct 2;17(1):178. Epub 2017 Oct 2.
    Department of Optometry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Background: In Ethiopia, there is a substantial mismatch between need and supply of corneal transplant. Although corneal transplantation service is affected by various factors, willingness to donate eyes is an essential indicator of its availability, accessibility, and acceptability. Therefore, this study aimed to determine the magnitude of willingness to donate eyes and its associated factors, which help to develop appropriate strategies that can address this undersupply and unmet need. Read More

    Associated factors, diagnosis and management of Acanthamoeba keratitis in a referral Center in Southern China.
    BMC Ophthalmol 2017 Oct 2;17(1):175. Epub 2017 Oct 2.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-Sen University, Guangzhou, 510064, China.
    Background: To analyse the associated factors, diagnosis, clinical manifestations and therapeutic effects of Acanthamoeba keratitis at a tertiary ophthalmic centre in Southern China.

    Methods: A retrospective clinical study was performed in fifteen patients who were admitted to Zhongshan Ophthalmic Centre (ZOC) from January 2004 to December 2014. The patients' pathogenesis-associated factors were analysed, and preoperative diagnoses were determined using corneal scraping cultures and/or confocal microscopy followed. Read More

    A chronological study of the bacterial pathogen changes in acute neonatal bacterial conjunctivitis in southern China.
    BMC Ophthalmol 2017 Sep 26;17(1):174. Epub 2017 Sep 26.
    Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, 6400 Freret Street, New Orleans, LA, 70118, USA.
    Background: The aim of the project is to retrospectively study the changes in bacterial pathogens in acute neonatal bacterial conjunctivitis from 2002 to 2016 in Southern China. The results may provide the guidance for drug choice for acute neonatal bacterial conjunctivitis.

    Methods: Secretion specimens for bacterial culture were taken from 485 cases with clinically diagnosed acute bacterial neonatal conjunctivitis. Read More

    Analysis of the VSX1 gene in sporadic keratoconus patients from China.
    BMC Ophthalmol 2017 Sep 26;17(1):173. Epub 2017 Sep 26.
    Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
    Background: Keratoconus normally presents as a sporadic disease. Although different studies have found sequence variants of the visual system homeobox 1 (VSX1) gene associated with keratoconus in humans, no research has detected such variants in sporadic keratoconus patients from China. To investigate the possibility of VSX1 being a candidate susceptibility gene for Chinese patients with sporadic keratoconus, we performed sequence screening of this gene in such patients. Read More

    Semi-automated quantification of hard exudates in colour fundus photographs diagnosed with diabetic retinopathy.
    BMC Ophthalmol 2017 Sep 20;17(1):172. Epub 2017 Sep 20.
    Smt. Kanuri Santhamma Retina Vitreous Centre, L.V.Prasad Eye Institute, Hyderabad, 500034, India.
    Background: Hard exudates (HEs) are the classical sign of diabetic retinopathy (DR) which is one of the leading causes of blindness, especially in developing countries. Accordingly, disease screening involves examining HEs qualitatively using fundus camera. However, for monitoring the treatment response, quantification of HEs becomes crucial and hence clinicians now seek to measure the area of HEs in the digital colour fundus (CF) photographs. Read More

    Ocular knowledge and practice among type 2 diabetic patients in a tertiary care hospital in Bangladesh.
    BMC Ophthalmol 2017 Sep 19;17(1):171. Epub 2017 Sep 19.
    Department of Biostatistics, Bangladesh University of Health Sciences, 125/1, Darus Salam, Mirpur-1, Dhaka, Bangladesh.
    Background And Aims: Diabetes mellitus is likely to have a major effect on vision, and adequate knowledge of its ocular manifestations is of substantial importance to diabetic patients. The study aimed to assess the ocular knowledge and practices among Type 2 diabetic patients of Bangladesh.

    Methods: This cross-sectional study included 122 diabetic patients from the outpatient department (OPD) of the apex diabetic healthcare hospital of the country under the sponsorship of the Diabetic Association of Bangladesh (BIRDEM). Read More

    Evaluation of preoperative speed of progression and its association with surgical outcomes in primary congenital glaucoma patients: a retrospective study.
    BMC Ophthalmol 2017 Sep 18;17(1):170. Epub 2017 Sep 18.
    Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, No. 639, Zhizaoju Road, Shanghai, 200011, People's Republic of China.
    Background: Surgeries are inevitable for treating primary congenital glaucoma (PCG) and risk factors of surgical failure play a key role in surgical decision making. The aim of this study was to investigate the influence of delay of surgery and preoperative speed of progression (SP) on the surgical outcomes in these patients.

    Methods: Medical records of 83 eyes of 51 PCG patients with trabeculotomy within 3 years were retrospectively observed. Read More

    Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography.
    BMC Ophthalmol 2017 Sep 15;17(1):167. Epub 2017 Sep 15.
    Yaoeda Eye Clinic, 2-1649-1 Naga-Chou, Nagaoka, Niigata, 940-0053, Japan.
    Background: To investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT).

    Methods: This study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3. Read More

    Descemet membrane detachment in femtosecond laser-assisted cataract surgery: a case report.
    BMC Ophthalmol 2017 Sep 16;17(1):169. Epub 2017 Sep 16.
    Eye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
    Background: Femtosecond laser-assisted cataract surgery (FLACS) has grown in popularity among ophthalmologists as a novel technique. However, descemet membrane detachment (DMD) began to be found as the complication after FLACS. We report a case of serious DMD following FLACS due to the inappropriate incision design. Read More

    Analysis of various factors affecting pupil size in patients with glaucoma.
    BMC Ophthalmol 2017 Sep 16;17(1):168. Epub 2017 Sep 16.
    Department of ophthalmology, College of Medicine, Dankook University, 119, Dandae-ro, Dnognam-gu, Cheonan-si, Chungnam, 31119, Republic of Korea.
    Background: Pupil size is an important factor in predicting post-operative satisfaction. We assessed the correlation between pupil size, measured by Humphrey static perimetry, and various affecting factors in patients with glaucoma.

    Methods: In total, 825 eyes of 415 patients were evaluated retrospectively. Read More

    Internal limiting membrane peeling and gas tamponade for myopic foveoschisis: a systematic review and meta-analysis.
    BMC Ophthalmol 2017 Sep 8;17(1):166. Epub 2017 Sep 8.
    Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road., Xi-Cheng District, Beijing, 100050, China.
    Background: Myopic foveoschisis (MF) is among the leading causes of visual loss in high myopia. However, it remains controversial whether internal limiting membrane (ILM) peeling or gas tamponade is necessary treatment option for MF.

    Methods: PubMed, EMBASE, CBM, CNKI, WANFANG DATA and VIP databases were systematically reviewed. Read More

    Plasma metabolomic study in Chinese patients with wet age-related macular degeneration.
    BMC Ophthalmol 2017 Sep 6;17(1):165. Epub 2017 Sep 6.
    Department of Ophthalmology, China-Japan Friendship Hospital, Yinghua Donglu, Chaoyang District, Beijing, 100029, China.
    Background: Age-related macular degeneration (AMD) is a leading disease associated with blindness. It has a high incidence and complex pathogenesis. We aimed to study the metabolomic characteristics in Chinese patients with wet AMD by analyzing the morning plasma of 20 healthy controls and 20 wet AMD patients for metabolic differences. Read More

    The quality of systematic reviews about interventions for refractive error can be improved: a review of systematic reviews.
    BMC Ophthalmol 2017 Sep 5;17(1):164. Epub 2017 Sep 5.
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
    Background: Systematic reviews should inform American Academy of Ophthalmology (AAO) Preferred Practice Pattern® (PPP) guidelines. The quality of systematic reviews related to the forthcoming Preferred Practice Pattern® guideline (PPP) Refractive Errors & Refractive Surgery is unknown. We sought to identify reliable systematic reviews to assist the AAO Refractive Errors & Refractive Surgery PPP. Read More

    Apln-CreERT:mT/mG reporter mice as a tool for sprouting angiogenesis study.
    BMC Ophthalmol 2017 Sep 2;17(1):163. Epub 2017 Sep 2.
    Department of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, 197 Ruijin Er Rd, Huangpu District, Shanghai, 200025, China.
    Background: Angiogenesis is defined as a new blood vessel sprouting from pre-existing vessels, and the sprouting angiogenesis is the start phase of angiogenesis, which is critical for both physiological and pathological processes, such as embryonic development, organ growth, wound healing, tumor growth, diabetic retinopathy and age-related macular degeneration. Better understanding of the mechanisms of sprout angiogenesis will provide a rationale for the treatments of these angiogenesis related diseases.

    Methods: mT/mG tool mice are crossed with Apln-CreERT mice to generate Apln-CreERT: mT/mG mice, then we used neonatal retinal angiogenesis model to observe the angiogenic pattern of Apln-CreERT:mT/mG mice compared with Cdh5-CreERT:mT/mG mice. Read More

    Prevalence, pattern and risk factors of retinal vein occlusion in an elderly population in Nepal: the Bhaktapur retina study.
    BMC Ophthalmol 2017 Sep 2;17(1):162. Epub 2017 Sep 2.
    Vrije University Medical Center, Amsterdam, The Netherlands.
    Background: This study aims to explore the prevalence, pattern and risk factors of retinal vein occlusion (RVO) in an elderly population of Nepal.

    Method: One thousand eight hundred sixty subjects of age 60 years and above were enrolled in a population-based, cross-sectional study. Detailed history, visual acuity, anterior segment and posterior segment examinations were done. Read More

    Portable OCT-assisted surgical treatment of intracorneal pre-Descemet epithelial cyst: a case report.
    BMC Ophthalmol 2017 Aug 29;17(1):160. Epub 2017 Aug 29.
    Department of Ophthalmology, Corneal Dystrophy Research Institute, Institute of Vision Research, Severance Biomedical Science Institute, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, Seoul, 120-752, South Korea.
    Background: Intracorneal epithelial cysts are a rare clinical condition that can occur anywhere in the corneal tissue; however, they appear most commonly in the stroma. They are sometimes challenging to treat because of their location, depth, and visual outcomes. Herein, we report a pre-Descemet epithelial cyst that was successfully treated surgically, with guidance from Fourier-domain optical coherence tomography (FD-OCT). Read More

    Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration.
    BMC Ophthalmol 2017 Aug 29;17(1):161. Epub 2017 Aug 29.
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Background: Lutein and zeaxanthin are suggested micronutrient supplements to prevent the progression of age-related macular degeneration (AMD), a leading cause of blindness worldwide. To monitor the levels of lutein/zeaxanthin in the macula, macular pigment optical density (MPOD) is measured. A commercially available device (MPSII®, Elektron Technology, Switzerland), using technology based on heterochromatic flicker photometry, can measure both absolute and estimated values of MPOD. Read More

    Combined Brown syndrome and superior oblique palsy without a trochlear nerve: case report.
    BMC Ophthalmol 2017 Aug 25;17(1):159. Epub 2017 Aug 25.
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166, Gumiro, Bundang-gu, Seongnam, Gyeonggi-do, 463-707, South Korea.
    Background: Congenital Brown syndrome is characterized by limited elevation particularly during adduction. The pathogenesis of congenital Brown syndrome is still controversial.

    Case Presentation: A 6-year-old boy had been tilting his head to the left since infancy. Read More

    Comparison of 12-month therapeutic effect of conbercept and ranibizumab for diabetic macular edema: a real-life clinical practice study.
    BMC Ophthalmol 2017 Aug 25;17(1):158. Epub 2017 Aug 25.
    Department of Ophthalmology, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, 200065, China.
    Background: To compare the efficacy of intravitreal conbercept and ranibizumab in the treatment of diabetic macular edema (DME) in a real-life clinical practice.

    Methods: This was a retrospective study. Among 62 Chinese patients with DME, 32 patients (36 eyes) received intravitreal conbercept (IVC) injections and 30 patients (32 eyes) received intravitreal ranibizumab (IVR) injections, once a month for 3 months followed by as needed therapy. Read More

    Applying next generation sequencing with microdroplet PCR to determine the disease-causing mutations in retinal dystrophies.
    BMC Ophthalmol 2017 Aug 24;17(1):157. Epub 2017 Aug 24.
    Intramural IT and Bioinformatics Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
    Background: Inherited Retinal dystrophy (IRD) is a broad group of inherited retinal disorders with heterogeneous genotypes and phenotypes. Next generation sequencing (NGS) methods have been broadly applied for analyzing patients with IRD. Here we report a novel approach to enrich the target gene panel by microdroplet PCR. Read More

    Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis.
    BMC Ophthalmol 2017 Aug 24;17(1):155. Epub 2017 Aug 24.
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Many patients who suffer unilateral non-arteritic anterior ischemic optic neuropathy (NAION) will eventually develop the same condition in their other eye, worrying them about losing vision in both eyes. The purpose of this meta-analysis is to determine whether it is possible to predict the visual outcome of the consecutive NAION event based on initial presentation and to compare mean visual loss of firstly versus secondly affected eyes.

    Methods: A systematic review and meta-analysis of studies published between January 1st 1966 and May 31st 2016 reporting on visual acuity and/or visual field loss of both affected eyes, measured either at presentation or follow-up following bilateral NAION. Read More

    Comparison of astigmatism prediction error taken with the Pentacam measurements, Baylor nomogram, and Barrett formula for toric intraocular lens implantation.
    BMC Ophthalmol 2017 Aug 24;17(1):156. Epub 2017 Aug 24.
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, #81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
    Background: To evaluate and compare the astigmatism prediction errors taken with the Pentacam measurements, Baylor nomogram, and Barrett formula for toric intraocular lens (IOL) implantation.

    Methods: Phacoemulsification with toric Precizon IOL implantation was performed in 41 eyes with corneal astigmatism (range, 1 to 5 diopters (D)) determined by IOLMaster and SimK on Pentacam. Preoperative corneal astigmatism measurements were obtained from IOLMaster readings (IOLMaster, Baylor-IOLMaster, and Barrett-IOLMaster) and Pentacam readings (SimK, Baylor-SimK, Barrett-SimK, wavefront, true net power, total corneal refractive power, and vector derived by manual vector summation using corneal front and back astigmatism). Read More

    Awareness and knowledge of glaucoma and associated factors among adults: a cross sectional study in Gondar Town, Northwest Ethiopia.
    BMC Ophthalmol 2017 Aug 24;17(1):154. Epub 2017 Aug 24.
    Department of Optometry, College of Medicine and Health Sciences, University of Gondar, P.O. BOX: 196, Gondar, Ethiopia.
    Background: Raising public awareness and knowledge about glaucoma is a key for early case identification and prevention of blindness. However, awareness and knowledge about glaucoma is unknown at community level, making provision of interventions difficult. This study was intended to assess the awareness and knowledge of adults about glaucoma and the factors affecting it in Gondar town, Northwest Ethiopia. Read More

    The association between socioeconomic status and visual impairments among primary glaucoma: the results from Nationwide Korean National Health Insurance Cohort from 2004 to 2013.
    BMC Ophthalmol 2017 Aug 23;17(1):153. Epub 2017 Aug 23.
    Institute of Health Services Research, Department of Preventive Medicine, College of Medicine, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
    Background: Glaucoma is one of the most leading causes of permanent visual impairments in Korea, and social expenses spent for the glaucoma are increasing. This study is to identify association between socioeconomic status and the visual impairments caused by primary glaucoma in Korea.

    Methods: This study is based on a cohort study using stratified representative samples in the National Health Insurance claim data from 2002 to 2013 with 1,025,340 representative subjects. Read More

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