2,101 results match your criteria BMC Ophthalmology[Journal]


Choroidal origin of endogenous Candida endophthalmitis.

Authors:
Mark P Breazzano

BMC Ophthalmol 2020 Jul 13;20(1):283. Epub 2020 Jul 13.

Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Irving Medical Center, New York-Presbyterian Hospital, 635 W 165th St, New York, NY, 10032, USA.

Endogenous Candida endophthalmitis (ECE) has been established with microscopic histopathology, both by autopsy and experimentation, to primarily originate from and involve the choroid. Zhuang et al. examined a series of patients with ECE using spectral-domain optical coherence tomography (SD-OCT) imaging and present a new classification scheme. Read More

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http://dx.doi.org/10.1186/s12886-020-01540-8DOI Listing

Clinical characteristics and prognosis of Total Rhegmatogenous retinal detachment: a matched case-control study.

BMC Ophthalmol 2020 Jul 13;20(1):286. Epub 2020 Jul 13.

Department of Ophthalmology, Chungnam National University Hospital, 282, Munhwa-ro, Jung-gu, Daejeon, Republic of Korea.

Background: Although many studies have reported clinical features, surgical outcomes of rhegmatogenous retinal detachment (RRD), studies focusing on total RRD are rare. In this study, we investigate the clinical characteristics, risk factors, and prognosis of total RRD.

Methods: A retrospective chart review was performed on cases of 44 total RRD and an age- and sex-matched 88 partial RRD. Read More

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http://dx.doi.org/10.1186/s12886-020-01560-4DOI Listing

Corneae from body donors in anatomy department: valuable use for clinical transplantation and experimental research.

BMC Ophthalmol 2020 Jul 13;20(1):284. Epub 2020 Jul 13.

Department of Ophthalmology, Saarland University Medical Center (UKS), Homburg, Germany.

Background: Explanted corneae are highly needed for the surgical management of patients with severe corneal diseases. The aim of this study was to determine whether the body donors from the Institute of Anatomy are a suitable source of donor corneae.

Methods: At the Institute of Anatomy at Saarland University Medical Center in Homburg, corneae are prelevated from body donors who had consented to the removal of tissues for transplantation purposes during their lifetime. Read More

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http://dx.doi.org/10.1186/s12886-020-01546-2DOI Listing

Spontaneous resolution of a traumatic cataract in a patient with an open-globe ocular injury: a case report.

BMC Ophthalmol 2020 Jul 13;20(1):285. Epub 2020 Jul 13.

Department of Ophthalmology, Qilu Hospital of Shandong University, 107#, Wenhua Xi Road, Jinan, Shandong, 250012, PR China.

Background: We report a case of spontaneous resolution of a traumatic cataract in a patient with an open-globe ocular injury. This case highlights the importance of conservative management in these types of cases, as excellent visual outcome is possible without invasive surgical intervention.

Case Presentation: A 13-year-old boy presented with a corneal laceration in the left eye caused by a neuter pen. Read More

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http://dx.doi.org/10.1186/s12886-020-01555-1DOI Listing

Ophthalmic manifestations of congenital protein C deficiency: a case report and mini review.

BMC Ophthalmol 2020 Jul 13;20(1):282. Epub 2020 Jul 13.

Eye research center, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran, IR, Iran.

Background: Homozygous protein C (PC) deficiency is a potentially fatal disease with ocular blinding presentation or sequela.

Case Presentation: A 5 month-old boy was presented for evaluation of leukocoria. He had a history of frequent bruises and PC deficiency, treated with warfarin. Read More

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http://dx.doi.org/10.1186/s12886-020-01424-xDOI Listing

Corneal biomechanical properties in myopic eyes evaluated via Scheimpflug imaging.

BMC Ophthalmol 2020 Jul 11;20(1):279. Epub 2020 Jul 11.

School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Background: To investigate the biomechanical properties of the cornea in myopic eyes using corneal visualization Scheimpflug technology (Corvis ST). The relationships between the biomechanical properties of the cornea and the degree of myopia were also investigated.

Methods: 265 eyes of 265 subjects were included. Read More

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http://dx.doi.org/10.1186/s12886-020-01530-wDOI Listing

Branch retinal artery occlusion secondary to high-altitude exposure and diabetic retinopathy: a case report.

BMC Ophthalmol 2020 Jul 11;20(1):281. Epub 2020 Jul 11.

Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, NO.95 Yong'an Road, Xicheng District, Beijing, 100050, China.

Background: To report a case of branch retinal artery occlusion (BRAO) secondary to high-altitude exposure and diabetic retinopathy (DR), and to characterize the retinal changes before and after hyperbaric oxygen (HBO) treatment.

Case Presentation: We present a case of a 42-year-old man with DR who travelled to Tibet (in China, 3800 m/12467 ft. above mean sea level). Read More

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http://dx.doi.org/10.1186/s12886-020-01563-1DOI Listing

Macular hole edge morphology predicts restoration of postoperative retinal microstructure and functional outcome.

BMC Ophthalmol 2020 Jul 11;20(1):280. Epub 2020 Jul 11.

Department of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang Province, China.

Background: To investigate the ability of intraoperative optical coherence tomography (iOCT) during macular hole (MH) surgery to image different hole edge configurations and predict the restoration of retinal microstructure and visual outcomes.

Methods: This retrospective case series study included 53 MH patients. One eye each was assessed with iOCT during vitrectomy after internal limiting membrane (ILM) peeling. Read More

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http://dx.doi.org/10.1186/s12886-020-01541-7DOI Listing

Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study.

BMC Ophthalmol 2020 Jul 11;20(1):278. Epub 2020 Jul 11.

Hankou Aier Eye Hospital, Wuhan, 430021, China.

Background: To observe the effects of chalazion and its treatments on meibomian gland function and morphology in the chalazion area.

Methods: This nonrandomized, prospective observational clinical study included 58 patients (67 eyelids) who were cured of chalazion, including 23 patients (23 eyelids) treated with a conservative method and 35 patients (44 eyelids) treated with surgery. Infrared meibomian gland photography combined with image analysis by ImageJ software was used to measure the chalazion area proportion. Read More

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http://dx.doi.org/10.1186/s12886-020-01557-zDOI Listing

Three-year outcome of aflibercept treatment for Japanese patients with neovascular age-related macular degeneration.

BMC Ophthalmol 2020 Jul 10;20(1):276. Epub 2020 Jul 10.

Department of Ophthalmology, Hirosaki University, Hirosaki-Shi, Aomori Pref., Japan.

Background: To evaluate the three-year outcome after intravitreal aflibercept injection (IAI) for neovascular age-related macular degeneration (nAMD).

Methods: Forty-nine treatment-naïve nAMD patients (50 eyes) were enrolled in this prospective study. The eyes received IAI at two-month intervals in the first year. Read More

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http://dx.doi.org/10.1186/s12886-020-01542-6DOI Listing

The protective effect of 3% diquafosol on meibomian gland morphology in glaucoma patients treated with prostaglandin analogs: a 12-month follow-up study.

BMC Ophthalmol 2020 Jul 10;20(1):277. Epub 2020 Jul 10.

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-Gu, Gwangju, 61469, South Korea.

Background: To determine if 3% diquafosol (DQS) can preserve the meibomian gland morphology in glaucoma patients treated with prostaglandin analogs (PGA) for a 12-month follow-up period.

Methods: This study included 84 eyes of 46 normal tension glaucoma (NTG) patients who were treated with either preservative-containing PGA (PC-PGA; 16 patients, 28 eyes), preservative-free PGA (PF-PGA; 21 patients, 39 eyes), or a combination of PC-PGA and 3% DQS (PC-PGA + DQS; 9 patients, 17 eyes). The meibography of the upper eyelid was acquired using Keratograph® 5 M at baseline and at each follow-up (1, 3, 6, 9, and 12 months). Read More

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http://dx.doi.org/10.1186/s12886-020-01550-6DOI Listing

Comparison of refractive outcomes after photorefractive keratectomy with different optical zones using Mel 90 excimer laser.

BMC Ophthalmol 2020 Jul 9;20(1):270. Epub 2020 Jul 9.

Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, Republic of Korea.

Background: A larger optical zone for photorefractive keratectomy may improve optical quality and stability. However, there is need for limiting ablation diameter in that a larger ablation diameter requires greater ablation depth, and minimizing ablation depth may reduce adverse effects on postoperative wound healing, haze and keratoectasia. In this study, we compared the changes in clinical outcomes and the degree of regression between a 6. Read More

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http://dx.doi.org/10.1186/s12886-020-01537-3DOI Listing
July 2020
1.075 Impact Factor

Unilateral multifocal choroiditis following EBV-positive mononucleosis responsive to immunosuppression: a case report.

BMC Ophthalmol 2020 Jul 9;20(1):273. Epub 2020 Jul 9.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 1905 W Taylor St, Chicago, IL, 60612, USA.

Background: Multifocal choroiditis (MFC) is a relatively uncommon bilateral inflammatory chorioretinopathy affecting Caucasian young women with myopia. We present images from a case of completely unilateral multifocal choroiditis following EBV-positive mononucleosis that demonstrated a dramatic clinical response to immunosuppression.

Case Presentation: A 20-year-old woman with bilateral high myopia (-6D) and a documented normal prior retinal examination presented with visual loss in the right eye 2 months following confirmed Epstein-Barr virus (EBV) positive mononucleosis. Read More

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http://dx.doi.org/10.1186/s12886-020-01525-7DOI Listing

Efficacy of intravitreal Lucentis injection on major and macular branch retinal vein occlusion.

BMC Ophthalmol 2020 Jul 9;20(1):274. Epub 2020 Jul 9.

Department of Ophthalmology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No.107, west wenhua road, Jinan, Shandong, 250012, P.R. China.

Background: The objective of our study was to assess the efficacy of intravitreal Lucentis injection on major and macular branch retinal vein occlusion (BRVO).

Methods: In this retrospective analysis, 43 patients (major BRVO n = 24; macular BRVO, n = 19) were treated with intravitreal injection of Lucentis with a 1 + PRN regimen, which is diagnosed by fluorescein fundus angiography (FFA). "1 + PRN", namely, one intravitreal injection of Lucentis at the baseline, and then continue or stop according to the condition of the patient. Read More

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http://dx.doi.org/10.1186/s12886-020-01544-4DOI Listing

Pathogenic role of the vitreous in angle-closure glaucoma with autosomal recessive bestrophinopathy: a case report.

BMC Ophthalmol 2020 Jul 9;20(1):271. Epub 2020 Jul 9.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, 100730, China.

Background: Autosomal recessive bestrophinopathy (ARB) is caused by homozygous or compound heterozygous mutations in the BEST1 gene and always accompanied with refractory angle-closure glaucoma (ACG). The exact mechanism for the pan-ocular abnormalities in ARB is still unknown and the management of ACG in these cases is challenging.

Case Presentation: A 26-year-old patient with a novel autosomal-recessively inherited c. Read More

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http://dx.doi.org/10.1186/s12886-020-01543-5DOI Listing

Symptoms of ocular surface disease in construction workers: comparative study with office workers.

BMC Ophthalmol 2020 Jul 9;20(1):272. Epub 2020 Jul 9.

Department of Clinical Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza García, Nuevo León, Mexico.

Background: To investigate and contrast the prevalence of dry eye symptoms in construction workers and office workers using the OSDI questionnaire.

Methods: A cross-sectional, observational study was conducted using the OSDI questionnaire to evaluate dry eye symptoms and associated risk factors. Sampled size calculation with a power of 80% and a 95% degree of confidence suggested the inclusion of 298 participants. Read More

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http://dx.doi.org/10.1186/s12886-020-01548-0DOI Listing

Safety and efficacy of ripasudil in Japanese patients with glaucoma or ocular hypertension: 12-month interim analysis of ROCK-J, a post-marketing surveillance study.

BMC Ophthalmol 2020 Jul 9;20(1):275. Epub 2020 Jul 9.

Post Marketing Surveillance Department, Kowa Co., Ltd., Tokyo, Japan.

Background: Ripasudil is approved in Japan for glaucoma or ocular hypertension (OH) when other treatments are ineffective or cannot be administered. Its long-term safety and efficacy are being examined in a post-marketing surveillance study; 12-month data are described here.

Methods: This prospective, open-label, observational study enrolled patients with glaucoma or OH who started ripasudil during routine care. Read More

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http://dx.doi.org/10.1186/s12886-020-01490-1DOI Listing

Association of anthropometric measures across the life-course with refractive error and ocular biometry at age 15 years.

BMC Ophthalmol 2020 Jul 8;20(1):269. Epub 2020 Jul 8.

Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Duckworth Lane, Bradford, BD9 6RJ, England.

Background: A recent Genome-wide association meta-analysis (GWAS) of refractive error reported shared genetics with anthropometric traits such as height, BMI and obesity. To explore a potential relationship with refractive error and ocular structure we performed a life-course analysis including both maternal and child characteristics using data from the Avon Longitudinal Study of Parents and Children cohort.

Methods: Measures collected across the life-course were analysed to explore the association of height, weight, and BMI with refractive error and ocular biometric measures at age 15 years from 1613children. Read More

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http://dx.doi.org/10.1186/s12886-020-01480-3DOI Listing

Effect of silicone oil on peripapillary capillary density in patients with rhegmatogenous retinal detachment.

BMC Ophthalmol 2020 Jul 7;20(1):268. Epub 2020 Jul 7.

Department of Ophthalmology, Peking Union Medical College Hospital, No.1 Shuai Fu Yuan, Dongcheng District, Beijing, 100730, China.

Purpose: To evaluate the effect of silicone oil (SO) on peripapillary blood flow using OCT angiography.

Methods: This prospective case series recruited patients with unilateral rhegmatogenous retinal detachment (RRD) who underwent vitrectomy and SO tamponade. Patients were examined before SO removal and at 10 days, 1 month, and 3 months after SO removal on a spectral domain OCT angiography device (RTVue XR Avanti, Optovue Inc. Read More

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http://dx.doi.org/10.1186/s12886-020-01533-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339486PMC

Multiple recurrent myxofibrosarcoma of the orbit: case report and review of the literature.

BMC Ophthalmol 2020 Jul 6;20(1):264. Epub 2020 Jul 6.

Department of Ophthalmology, West China Hospital of Sichuan University, No. 37 Guoxue Xiang, Wuhou District, Chengdu, 610041, Sichuan Province, China.

Background: Although myxofibrosarcoma (MFS) is the most common mesenchymal tumor, occurrence in the orbit is extremely rare. A characteristic clinical feature of MFS is its propensity for local recurrence (LR). Still, none of published literature has described the entire clinical course of multiple recurrences of MFS in the orbit. Read More

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http://dx.doi.org/10.1186/s12886-020-01458-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336468PMC

Surgical outcomes of the removal of posterior segment metallic intraocular foreign bodies.

BMC Ophthalmol 2020 Jul 6;20(1):267. Epub 2020 Jul 6.

Department of Ophthalmology, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung, 813, Taiwan, Republic of China.

Background: Posterior segment metallic intraocular foreign bodies (IOFBs) are a leading cause of visual morbidity and blindness, especially among young and middle-aged working populations. Here, we aimed to evaluate the surgical outcomes of the removal of such IOFBs that result from injuries.

Methods: In this retrospective study, 39 patients injured by metallic posterior segment IOFBs and who underwent primary repair procedures, vitrectomies, and IOFBs removal with or without procedures for traumatic cataract removal, scleral buckling and intraoperative tamponade application from January, 2008 to January, 2019. Read More

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http://dx.doi.org/10.1186/s12886-020-01535-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339457PMC

Subthreshold yellow laser for fovea-involving diabetic macular edema in a series of patients with good vision: effectiveness and safety of a fovea-sparing technique.

BMC Ophthalmol 2020 Jul 6;20(1):266. Epub 2020 Jul 6.

Ophthalmology department, Joan XXIII University Hospital, Rovira i Virgili University, Mallafré i Guasch, 4, 43002, Tarragona, Spain.

Purpose: Patients with center-involved diabetic macular edema (CI-DME) with good visual acuity (VA) represent a controversial clinical scenario in which a subthreshold laser might be a reasonable approach. We report a case series of patients with CI-DME with VA better than 20/32 who were treated with a subthreshold 577 nm (yellow) laser.

Methods: The area of retinal thickening on OCT was treated with confluent laser spots at individually titrated power. Read More

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http://dx.doi.org/10.1186/s12886-020-01536-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339496PMC

Seasonal variation in the occurrence of retinal vein occlusion: a 4-year cross-sectional study.

BMC Ophthalmol 2020 Jul 6;20(1):265. Epub 2020 Jul 6.

Department of Ophthalmology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, Japan.

Background: Retinal vein occlusion (RVO) is a common retinal vascular disease that causes a loss of vision. Therefore, we investigated whether there is seasonal variation in the onset of RVO, to examine the possibility of preventing it.

Methods: Patients with RVO who were treated at the Juntendo University Urayasu Hospital between April 2013 and March 2017 were included in this retrospective study. Read More

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http://dx.doi.org/10.1186/s12886-020-01534-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339458PMC

Case report-immune recovery posterior scleritis in a HIV positive patient.

BMC Ophthalmol 2020 Jul 2;20(1):262. Epub 2020 Jul 2.

Department of Ophthalmology, Huashan Hospital of Fudan University, No. 12, Middle Urumqi Road, Shanghai, 200040, China.

Background: Posterior scleritis is an uncommon vision-threatening disorder that is often recurrent and difficult to cure due to its complex etiology. In HIV patients, posterior scleritis may develop several months after significant rise in CD4+ T-lymphocyte, even after several years, which may be diagnosed as late-onset immune recovery scleritis.

Case Presentation: Here we report a case of posterior scleritis in a HIV positive patient who presented with severe periocular pain and decreased vision in the left eye, with exudative retinal detachment and optic nerve involvement. Read More

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http://dx.doi.org/10.1186/s12886-020-01529-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330949PMC

A predictive model for early diagnosis of keratoconus.

BMC Ophthalmol 2020 Jul 2;20(1):263. Epub 2020 Jul 2.

UGC Ophthalmology, Torrecárdenas University Hospital, Almería, Spain.

Background: The diagnosis of keratoconus in the early stages of the disease is necessary to initiate an early treatment of keratoconus. Furthermore, to avoid possible refractive surgery that could produce ectasias. This study aims to describe the topographic, pachymetric and aberrometry characteristics in patients with keratoconus, subclinical keratoconus and normal corneas. Read More

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http://dx.doi.org/10.1186/s12886-020-01531-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331257PMC

Levels of cytokines in the aqueous humor guided treatment of refractory macular edema in adult-onset coats' disease.

BMC Ophthalmol 2020 Jun 30;20(1):261. Epub 2020 Jun 30.

Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, No. 8, South Road of Worker's Stadium, Chaoyang District, Beijing, 100020, China.

Background: Two cases with refractory macular edema secondary to adult-onset Coats' disease underwent unsatisfactory treatment by intravitreal injections of anti-vascular endothelial growth factor (VEGF) drugs and retinal photocoagulation.

Case Presentation: The authors highlight the guiding effect of the measurement of cytokines in the aqueous humor for the treatment of adult-onset Coats' disease with refractory macular edema. In the two cases, typical Coats' disease changes, including telangiectasis, subretinal exudation and macular edema were observed. Read More

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http://dx.doi.org/10.1186/s12886-020-01474-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329434PMC

Speed and accuracy of saccades in patients with glaucoma evaluated using an eye tracking perimeter.

BMC Ophthalmol 2020 Jun 30;20(1):259. Epub 2020 Jun 30.

University of Edinburgh, Edinburgh, UK.

Background: To examine the speed and accuracy of saccadic eye movements during a novel eye tracking threshold visual field assessment and determine whether eye movement parameters may improve ability to detect glaucoma.

Methods: A prospective study including both eyes of 31 patients with glaucoma and 23 controls. Standard automated perimetry (SAP) and eye tracking perimetry (saccadic vector optokinetic perimetry, SVOP) was performed. Read More

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http://dx.doi.org/10.1186/s12886-020-01528-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325566PMC

Optical coherence tomography angiography (OCTA) findings in Serpiginous Choroiditis.

BMC Ophthalmol 2020 Jun 30;20(1):258. Epub 2020 Jun 30.

Department of Ophthalmology, Campus Virchow- Klinikum, Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt- Universität zu Berlin and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: To describe changes in the retina/choroid in patients with Serpiginous Choroiditis (SC) by Optical Coherence Tomography Angiography (OCTA) in a multimodal imaging approach.

Methods: Prospective, monocentric study of 24 eyes of 12 consenting patients diagnosed with SC, who underwent OCTA, which was analyzed and compared to other methods such as enhanced depth imaging-OCT, fluorescein angiography, indocyanine green angiography, and fundus autofluorescence.

Results: The study group consisted of 9 patients with peripapillary SC, 1 macular SC, and 2 atypical cases. Read More

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http://dx.doi.org/10.1186/s12886-020-01527-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325353PMC
June 2020
1.075 Impact Factor

Elevated vitreous Lipocalin-2 levels of patients with proliferative diabetic retinopathy.

BMC Ophthalmol 2020 Jun 30;20(1):260. Epub 2020 Jun 30.

Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, China.

Background: Lipocalin-2 (LCN2) is a novel adipokine with potential roles in obesity, insulin resistance, and inflammation. This study aims to assess the concentrations of LCN2 and vascular endothelial growth factor (VEGF) expressed in the vitreous humors of patients with proliferative diabetic retinopathy (PDR).

Methods: The concentrations of LCN2 and VEGF were measured from the vitreous of 67 patients undergoing vitrectomy (20 controls and 47 PDR) via enzyme-linked immunosorbent assay (ELISA). Read More

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http://dx.doi.org/10.1186/s12886-020-01462-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329527PMC

Cost-effectiveness of immediate versus delayed sequential bilateral cataract surgery in the Netherlands (the BICAT-NL study): study design of a prospective multicenter randomised controlled trial.

BMC Ophthalmol 2020 Jun 29;20(1):257. Epub 2020 Jun 29.

Maastricht University Medical Center+, University Eye Clinic Maastricht, P. Debyelaan 25, 6229 HX, Maastricht, the Netherlands.

Background: Cataract surgery is one of the most frequently performed types of surgery. Most patients suffer from bilateral cataract and while cataract surgery of only one eye is effective in restoring functional vision, second-eye surgery leads to further improvements in health-related quality of life, and is cost-effective. At present, most patients undergo cataract surgery in both eyes on separate days as recommended in national guidelines, referred to as delayed sequential bilateral cataract surgery (DSBCS). Read More

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http://dx.doi.org/10.1186/s12886-020-01521-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323372PMC

Clinical analysis and predictive factors associated with improved visual acuity of infectious endophthalmitis.

BMC Ophthalmol 2020 Jun 29;20(1):256. Epub 2020 Jun 29.

Department of Ophthalmfology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Tianjin, 300052, China.

Background: To describe the clinical characteristics and analyze the predictive factors associated with improved visual acuity of 359 patients with infectious endophthalmitis.

Methods: This study retrospectively analyzed 359 eyes of 359 patients with infectious endophthalmitis from January 2014 to December 2018. The findings summarized some epidemiological characteristics of these patients, including age, sex, occupation, patient visit time, etiology, causative organisms, therapy, and best-corrected visual acuity. Read More

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http://dx.doi.org/10.1186/s12886-020-01517-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325235PMC

Heimann-Bielschowsky phenomenon and hypotropic DVD in case of monocular vision loss: a case report.

BMC Ophthalmol 2020 Jun 26;20(1):254. Epub 2020 Jun 26.

Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu, South Korea.

Background: The Heimann-Bielschowsky phenomenon (HBP) is an underrecognized condition characterized by slow, pendular, vertical oscillations of the eye accompanying monocular vision loss. Hypotropic dissociated vertical deviation (DVD) is another rare condition induced by asymmetric visual input. This report documents a rare case of HBP with hypotropic DVD. Read More

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http://dx.doi.org/10.1186/s12886-020-01502-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318472PMC

Association of 5p15.2 and 15q14 with high myopia in Tujia and Miao Chinese populations.

BMC Ophthalmol 2020 Jun 26;20(1):255. Epub 2020 Jun 26.

Department of Hubei Minzu University Affiliated Enshi Clinical Medical School, The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture, No.158, Wuyang Road, Enshi, 445000, Hubei Provence, China.

Background: The polymorphisms rs6885224 and rs634990 have been reported to be associated with high myopia in many populations. As there is still no report on whether these two SNPs are associated with myopia in the Tujia and Miao minority areas of China, we conducted a replication study to evaluate the association of single-nucleotide polymorphisms in the regions 5p15.2 and 15q14 with high myopia in Tujia and Miao Chinese populations. Read More

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http://dx.doi.org/10.1186/s12886-020-01516-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318420PMC
June 2020
1.075 Impact Factor

The effect of dot size in random-dot stereograms on the results of stereoacuity measurements.

BMC Ophthalmol 2020 Jun 24;20(1):253. Epub 2020 Jun 24.

Department of Optometry, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Nanguan District, Changchun, 130041, China.

Background: This study aimed to evaluate the effect of the size of the dots in random-dot stereograms on the results of stereoacuity measurements.

Methods: A stereopsis measurement system was created using a phoropter and two 4 K smartphones. Three dot sizes, including 1 × 1 pixel, 6 × 6 pixels, and 10 × 10 pixels (equivalent to 0. Read More

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http://dx.doi.org/10.1186/s12886-020-01526-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313195PMC

Vogt-Koyanagi-Harada disease-like uveitis following nivolumab administration treated with steroid pulse therapy: a case report.

BMC Ophthalmol 2020 Jun 24;20(1):252. Epub 2020 Jun 24.

Department of Ophthalmology, Kameda Medical Center, Kamogawa, Japan.

Background: Immune checkpoint inhibitors can cause various adverse effects. Recently it has been shown that Vogt-Koyanagi-Harada (VKH) disease-like uveitis can occur in patients treated with nivolumab.

Case Presentation: A 69-year-old man developed bilateral panuveitis after nivolumab treatment for recurrent hypopharyngeal cancer. Read More

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http://dx.doi.org/10.1186/s12886-020-01519-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313170PMC

Retraction Note: Comparison of 0.05% cyclosporine and 3% diquafosol solution for dry eye patients: a randomized, blinded, multicenter clinical trial.

BMC Ophthalmol 2020 06 23;20(1):251. Epub 2020 Jun 23.

Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul, 07345, South Korea.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s12886-020-01524-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310420PMC

Multimodal imaging in sclerochoroidal calcification: a case report and literature review.

BMC Ophthalmol 2020 Jun 22;20(1):248. Epub 2020 Jun 22.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Background: Sclerochoroidal calcification (SCC), a rare condition found in elderly people, is idiopathic or occasionally secondary to disorders affecting calcium metabolism. Findings of multimodal imaging including choroidal circulation are, however, largely unknown. We present a patient of SCC with systemic background, who underwent multimodal imaging evaluations. Read More

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http://dx.doi.org/10.1186/s12886-020-01520-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310239PMC

Eiology and prognosis of canalicular laceration repair using canalicular anastomosis combined with bicanalicular stent intubation.

BMC Ophthalmol 2020 Jun 22;20(1):246. Epub 2020 Jun 22.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No 639 ZhiZaoJu Road, Shanghai, 200011, China.

Background: To evaluate the etiology of lacrimal canalicular laceration and explore the possible risk factors influencing prognosis.

Methods: The data of 142 patients (142 eyes) with lacrimal canalicular lacerations who were surgically treated using canalicular anastomosis combined with bicanalicular stent intubation between March 2017 and March 2018 were reviewed. The analyzed data contained demographic information, types of trauma, injury locations, associated additional ocular injuries, and surgical outcomes at follow-up. Read More

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http://dx.doi.org/10.1186/s12886-020-01506-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310031PMC
June 2020
1.075 Impact Factor

Acute retinal necrosis following dexamethasone intravitreal implant (Ozurdex®) administration in an immunocompetent adult with a history of HSV encephalitis: a case report.

BMC Ophthalmol 2020 Jun 22;20(1):247. Epub 2020 Jun 22.

Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, Zhejiang, People's Republic of China.

Background: Dexamethasone intravitreal implants (0.7 mg) (Ozurdex®, Allergan Inc., Madison, NJ) are FDA approved for managing macular oedema (ME) of retinal vein occlusion (RVO). Read More

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http://dx.doi.org/10.1186/s12886-020-01514-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310153PMC
June 2020
1.075 Impact Factor

Comparison of fundus changes following silicone oil and sterilized air tamponade for macular-on retinal detachment patients.

BMC Ophthalmol 2020 Jun 22;20(1):249. Epub 2020 Jun 22.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: To investigate different tamponade effects of intravitreal silicone oil (SO) and sterilized air on macular vasculature and structure after successful retinal repair for macular-on rhegmatogenous retinal detachment (RRD) patients.

Method: 21 eyes (21 patients) with macular-on RRD underwent single pars plana vitrectomy following intravitreal SO or sterilized air (Gas) tamponade. Optical Coherence Tomography (OCT) and angiography were used to evaluate retinal layer thickness and flow density (FD) changes throughout the observation period of 12 weeks. Read More

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http://dx.doi.org/10.1186/s12886-020-01523-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310510PMC
June 2020
1.075 Impact Factor

Lhasa childhood eye study: the rationale, methodology, and baseline data of a 5 year follow-up of school-based cohort study in the Tibetan plateau region of Southwest China.

BMC Ophthalmol 2020 Jun 22;20(1):250. Epub 2020 Jun 22.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, 100730, China.

Background: Tibetan Plateau is a highland area with special geographical location, time zone, and ethnic composition. We herein report the rationale, methodology and baseline data of the school-based childhood cohort study named Lhasa Childhood Eye Study (LCES), with the primary objective to pursue a comprehensive understanding on the longitudinal trends of refractive error as well as other ocular diseases and to address the differences between Tibetan Plateau and other parts of the world.

Methods: Grade one students from primary schools in Lhasa were cluster randomly selected. Read More

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http://dx.doi.org/10.1186/s12886-020-01522-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310065PMC
June 2020
1.075 Impact Factor

Surgical procedure of canaliculoplasty in the treatment of primary canaliculitis associated with canalicular dilatation.

BMC Ophthalmol 2020 Jun 20;20(1):245. Epub 2020 Jun 20.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China.

Background: Primary canaliculitis is a chronic infection of the proximal lacrimal pathway. We aimed to evaluate surgical outcomes of a canaliculoplasty procedure for primary canaliculitis associated with canalicular dilatation.

Methods: This study enrolled 42 primary canaliculitis patients with canalicular dilatation who underwent canaliculoplasty. Read More

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http://dx.doi.org/10.1186/s12886-020-01503-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305593PMC

Conjunctival structure of glaucomatous eyes treated with anti-glaucoma eye drops: a cross-sectional study using anterior segment optical coherence tomography.

BMC Ophthalmol 2020 Jun 19;20(1):244. Epub 2020 Jun 19.

Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Yoshida, Fukui, 910-1193, Japan.

Background: To determine the effect of various factors to the preservation rate of the conjunctival layer borderlines of glaucomatous eyes treated with anti-glaucoma eye drops.

Methods: Anterior segment optical coherence tomography (AS-OCT) images of the bulbar conjunctiva of 328 eyes were analyzed with and without anti-glaucoma eye drops to quantify the preservation rates of the conjunctival layer borderlines.

Results: More anti-glaucoma eye drops and a longer duration of administration were associated with lower preservation rates of the borderlines between both the conjunctival stroma/Tenon's capsule (P < 0. Read More

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http://dx.doi.org/10.1186/s12886-020-01518-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304144PMC

Thickness profiles of the corneal epithelium along the steep and flat meridians of astigmatic corneas after orthokeratology.

BMC Ophthalmol 2020 Jun 19;20(1):240. Epub 2020 Jun 19.

Department of Ophthalmology, Eye and ENT Hospital, Fudan University; Key Laboratory of Myopia of The State Health Ministry, 200031, 83 Fenyang Road, Shanghai, People's Republic of China.

Background: The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear.

Methods: This is a prospective study. Fifty-seven subjects with up to 1. Read More

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http://dx.doi.org/10.1186/s12886-020-01477-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304131PMC

Combination of Ranibizumab with macular laser for macular edema secondary to branch retinal vein occlusion: one-year results from a randomized controlled double-blind trial.

BMC Ophthalmol 2020 Jun 19;20(1):241. Epub 2020 Jun 19.

Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Background: It is not clear whether macular laser combined with anti-vascular endothelial growth factor (VEGF) can reduce the number of anti-VEGF injections in the treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). Our study aimed to investigate the effects of intravitreal ranibizumab with or without macular laser for ME secondary to BRVO and its associated number of anti-VEGF injections.

Methods: This is a prospective, randomized, double-blind, monocentric trial. Read More

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http://dx.doi.org/10.1186/s12886-020-01498-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304204PMC

Clinical utility of aqueous humor polymerase chain reaction and serologic testing for suspected infectious uveitis: a single-center retrospective study in South Korea.

BMC Ophthalmol 2020 Jun 19;20(1):242. Epub 2020 Jun 19.

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 135-720, South Korea.

Background: This study aimed to assess and compare the clinical value of aqueous humor polymerase chain reaction (PCR) and serologic tests in patients diagnosed with suspected infectious uveitis.

Methods: In this retrospective observational study, data of 358 patients who were diagnosed with suspected infectious uveitis and who underwent aqueous humor PCR testing were analyzed. PCR and serologic test results were compared with the clinical features. Read More

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http://dx.doi.org/10.1186/s12886-020-01513-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304133PMC
June 2020
1.075 Impact Factor

Comparison of clinical results between trans-PRK and femtosecond LASIK for correction of high myopia.

BMC Ophthalmol 2020 Jun 19;20(1):243. Epub 2020 Jun 19.

Qingdao Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, 266071, Shandong Province, China.

Background: To compare the clinical outcomes of transepithelial photorefractive keratectomy (TPRK) with femtosecond laser-assisted in situ keratomileusis (FS-LASIK) for correction of high myopia.

Methods: In this prospective, non-randomised, cohort study, 85 eyes of 46 patients treated with TPRK and 80 eyes of 42 patients treated with FS-LASIK were included. All eyes were highly myopic (spherical equivalent refraction <- 6. Read More

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http://dx.doi.org/10.1186/s12886-020-01515-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304146PMC

Short-time evaluation on intraocular scattering after implantable collamer lens implantation for correcting high myopia.

BMC Ophthalmol 2020 Jun 17;20(1):235. Epub 2020 Jun 17.

Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology, Tianjin Medical University, Nankai University Eye Hospital, No. 4 Gansu Road, Heping District, Tianjin, People's Republic of China.

Background: To compare the intraocular scattering before and after implantation of implantable collamer lens (ICL) V4c for correction of high myopia in a short term.

Methods: In this study, 38 eyes of 19 patients who underwent the implantation of ICL V4c were followed up for 3 months. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), objective scattering index (OSI), modulation transfer function cutoff frequency (MTF cutoff), strehl ratio (S/R), OV100%, OV20% and OV9% were measured pre- and postoperatively. Read More

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http://dx.doi.org/10.1186/s12886-020-01482-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301533PMC
June 2020
1.075 Impact Factor

Refractive, visual, and subjective quality of vision outcomes for very high myopia LASIK from - 10.00 to - 13.50 diopters.

BMC Ophthalmol 2020 Jun 17;20(1):234. Epub 2020 Jun 17.

LASIK MD, 1250 Rene-Levesque Blvd W, MD Level, Montreal, QC, H3B 4W8, Canada.

Background: To evaluate laser-assisted in situ keratomileusis (LASIK) outcomes, subjective quality of vision (QoV) and patient satisfaction in eyes with very high myopia (VHM) above - 10.00 diopters (D).

Methods: Consecutive myopic and myopic-astigmatism eyes with spherical equivalent (SEQ) ranging between - 10. Read More

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http://dx.doi.org/10.1186/s12886-020-01481-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302155PMC

Correlation of binocular refractive error and calculation of intraocular Lens power for the second eye.

BMC Ophthalmol 2020 Jun 18;20(1):237. Epub 2020 Jun 18.

Department of Ophthalmology, University of Heidelberg, 69120, Heidelberg, Germany.

Background: Reducing refractive error has always been a tricky problem. The aim of this study was to verify the correlation between binocular refractive error (RE) after sequential cataract surgery and explore an individualized calculation method of intraocular lens (IOL) for the second eye.

Methods: This was a prospective study. Read More

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http://dx.doi.org/10.1186/s12886-020-01496-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302342PMC