1,793 results match your criteria BMC Neuroscience [Journal]


Offline encoding impaired by epigenetic regulations of monoamines in the guided propagation model of autism.

BMC Neurosci 2018 Dec 17;19(1):80. Epub 2018 Dec 17.

LIMSI (Computer Sciences Laboratory for Mechanics and Engineering Sciences), CNRS, rue John Von Neumann, Campus Universitaire d'Orsay - Bâtiment 508, 91403, Orsay Cedex, France.

Background: Environmental factors can modify the expression of genes, including those involved in the metabolism of neurotransmitters. Accounting for a control role of monoamine neurotransmitters, the guided propagation (GP) memory model may contribute to investigate the consequences of neuromodulation impairments on development disorders such as autism. A prenatal transient excess of 'monoamine oxidase A' enzyme is assumed here to trigger persistent epigenetic regulations that would induce imbalanced metabolisms of synaptic monoamines. Read More

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http://dx.doi.org/10.1186/s12868-018-0477-1DOI Listing
December 2018

Altered Slc25 family gene expression as markers of mitochondrial dysfunction in brain regions under experimental mixed anxiety/depression-like disorder.

BMC Neurosci 2018 Dec 11;19(1):79. Epub 2018 Dec 11.

Laboratory of Neuropathology Modeling, The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.

Background: Development of anxiety- and depression-like states under chronic social defeat stress in mice has been shown by many experimental studies. In this article, the differentially expressed Slc25* family genes encoding mitochondrial carrier proteins were analyzed in the brain of depressive (defeated) mice versus aggressive mice winning in everyday social confrontations. The collected samples of brain regions were sequenced at JSC Genoanalytica ( http://genoanalytica. Read More

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http://dx.doi.org/10.1186/s12868-018-0480-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288882PMC
December 2018

The effect of anesthetic dose on the motor response induced by low-intensity pulsed ultrasound stimulation.

BMC Neurosci 2018 Dec 3;19(1):78. Epub 2018 Dec 3.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.

Background: Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state of the mice. However, the quantitative relationship between motor response and anesthetic dose remains unclear. Read More

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http://dx.doi.org/10.1186/s12868-018-0476-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278113PMC
December 2018

PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration.

BMC Neurosci 2018 Nov 29;19(1):76. Epub 2018 Nov 29.

Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA.

Background: Global cerebral ischemia triggers neurodegeneration in the hippocampal CA1 region, but the mechanism of neuronal death remains elusive. The epsilon isoform of protein kinase C (PKCε) has recently been identified as a master switch that controls the nucleocytoplasmic trafficking of ATF2 and the survival of melanoma cells. It is of interest to assess the role of PKCε-ATF2 signaling in neurodegeneration. Read More

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http://dx.doi.org/10.1186/s12868-018-0479-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267029PMC
November 2018

Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation.

BMC Neurosci 2018 Nov 29;19(1):77. Epub 2018 Nov 29.

Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.

Background: The treatment of Parkinson's disease is often complicated by levodopa-induced dyskinesia (LID). Nicotinic acetylcholine receptor agonists can alleviate LID in animal models but may be less effective in conditions of severe dopaminergic denervation. While the mechanisms of LID remain incompletely understood, elevated corticostriatal levels of the brain-derived neurotrophic factor (BDNF) have been suggested to play a role. Read More

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http://dx.doi.org/10.1186/s12868-018-0478-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267795PMC
November 2018
1 Read

Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla H-MRS study.

BMC Neurosci 2018 Nov 20;19(1):75. Epub 2018 Nov 20.

Department of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.

Background: Traumatic brain injury (TBI) is a complex condition and remains a prominent public and medical health issue in individuals of all ages. A rapid increase in extracellular glutamate occurs after TBI, leading to glutamate-induced excitotoxicity, which causes neuronal damage and further functional impairments. Although inhibition of glutamate carboxypeptidase II (GCP II) is considered a potential approach for reducing glutamate-induced excitotoxicity after TBI, further detailed evidence regarding its efficacy is required. Read More

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http://dx.doi.org/10.1186/s12868-018-0473-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245916PMC
November 2018
4 Reads

Biaryl scaffold-focused virtual screening for anti-aggregatory and neuroprotective effects in Alzheimer's disease.

BMC Neurosci 2018 Nov 13;19(1):74. Epub 2018 Nov 13.

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

Background: Alzheimer's disease (AD) is a primary cause of dementia in ageing population affecting more than 35 million people around the globe. It is a chronic neurodegenerative disease caused by defected folding and aggregation of amyloid beta (Aβ) protein. Aβ is formed by the cleavage of membrane embedded amyloid precursor protein (APP) by using enzyme 'transmembrane aspartyl protease, β-secretase'. Read More

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http://dx.doi.org/10.1186/s12868-018-0472-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234579PMC
November 2018
11 Reads
2.665 Impact Factor

Downregulation of calcium-dependent NMDA receptor desensitization by sodium-calcium exchangers: a role of membrane cholesterol.

BMC Neurosci 2018 Nov 12;19(1):73. Epub 2018 Nov 12.

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Torez 44, Saint-Petersburg, Russia.

Background: The plasma membrane Na/Ca-exchanger (NCX) has recently been shown to regulate Ca-dependent N-methyl-D-aspartate receptor (NMDAR) desensitization, suggesting a tight interaction of NCXs and NMDARs in lipid nanoclasters or "rafts". To evaluate possible role of this interaction we studied effects of Li on NMDA-elicited whole-cell currents and Ca responses of rat cortical neurons in vitro before and after cholesterol extraction by methyl-β-cyclodextrin (MβCD).

Results: Substitution Li for Na in the external solution caused a concentration-dependent decrease of steady-state NMDAR currents from 440 ± 71 pA to 111 ± 29 pA in 140 mM Na and 140 mM Li, respectively. Read More

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http://dx.doi.org/10.1186/s12868-018-0475-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233507PMC
November 2018

Abstracts of the 6th Meeting of the Neapolitan Brain Group.

Authors:

BMC Neurosci 2018 Nov 13;19(Suppl 3):67. Epub 2018 Nov 13.

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http://dx.doi.org/10.1186/s12868-018-0466-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233258PMC
November 2018

Riboflavin and pyridoxine restore dopamine levels and reduce oxidative stress in brain of rats.

BMC Neurosci 2018 Nov 9;19(1):71. Epub 2018 Nov 9.

Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), Mexico City, Mexico.

Background: Neurological disorders suggest that the excitotoxicity involves a drastic increase in intracellular Ca concentrations and the formation of reactive oxygen species. The presence of these free radicals may also affect the dopaminergic system. The aim of this work was to determine if riboflavin (B) and pyridoxine (B) provide protection to the brain against free radicals generated by 3-nitropropionic acid (3-NPA) by measuring the levels of dopamine (DA) and selected oxidative stress markers. Read More

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http://dx.doi.org/10.1186/s12868-018-0474-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230234PMC
November 2018
5 Reads

Glycine receptors expression in rat spinal cord and dorsal root ganglion in prostaglandin E2 intrathecal injection models.

BMC Neurosci 2018 Nov 9;19(1):72. Epub 2018 Nov 9.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. The GlyRα3 subunit has recently emerged as a key factor in inflammatory pain pathways in the spinal cord dorsal horn (DH). Our study is to identify the extent of location and cell types expressing different GlyR subunits in spinal cord and dorsal root ganglion (DRGs). Read More

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http://dx.doi.org/10.1186/s12868-018-0470-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230273PMC
November 2018

Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.

BMC Neurosci 2018 Nov 6;19(1):69. Epub 2018 Nov 6.

Department of Animal Behavior, Freie Universität Berlin, Takustraße 6, 14195, Berlin, Germany.

Background: FoxP transcription factors play crucial roles for the development and function of vertebrate brains. In humans the neurally expressed FOXPs, FOXP1, FOXP2, and FOXP4 are implicated in cognition, including language. Neural FoxP expression is specific to particular brain regions but FoxP1, FoxP2 and FoxP4 are not limited to a particular neuron or neurotransmitter type. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0469-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219247PMC
November 2018
3 Reads

PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.

BMC Neurosci 2018 Nov 6;19(1):70. Epub 2018 Nov 6.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Background: The proteasome system plays an important role in synaptic plasticity. Induction and maintenance of long term potentiation is directly dependent on selective targeting of proteins for proteasomal degradation. The 20S proteasome activator PA28αβ activates hydrolysis of small nonubiquitinated peptides and possesses protective functions upon oxidative stress and proteinopathy. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0468-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218978PMC
November 2018
3 Reads

The significance of anti-neuronal antibodies for acute psychiatric disorders: a retrospective case-controlled study.

BMC Neurosci 2018 Nov 3;19(1):68. Epub 2018 Nov 3.

Department of Mental Health, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Background: The clinical significance of anti-neuronal antibodies in patients with psychiatric disorders, but without encephalitis, remains unknown. In patients admitted to acute psychiatric inpatient care we aimed to identify clinical features distinguishing anti-neuronal antibody positive patients from matched controls.

Results: Patients who were serum-positive to N-methyl D-aspartate receptor (NMDAR) (n = 21), contactin-associated protein 2 (CASPR2) (n = 14) and/or glutamic acid decarboxylase 65 (GAD65) (n = 9) antibodies (cases) were age and sex matched (1:2) with serum-negative patients from the same cohort (controls). Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0471-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215671PMC
November 2018
4 Reads

Transcranial direct current stimulation for the treatment of tinnitus: a review of clinical trials and mechanisms of action.

BMC Neurosci 2018 Oct 25;19(1):66. Epub 2018 Oct 25.

Biomedical Engineering Department, Polytechnic University of Pachuca, Zempoala, Mexico.

Background: Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous therapeutic outcomes for tinnitus. The present study aims to review the recent advances in applications of tDCS for tinnitus treatment. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0467-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202858PMC
October 2018
6 Reads
2.665 Impact Factor

Functional EEG connectivity during competition.

BMC Neurosci 2018 Oct 18;19(1):63. Epub 2018 Oct 18.

Research Unit in Affective and Social Neuroscience, Catholic University of the Sacred Heart, Milan, Italy.

Background: Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since it stresses the relevance and salience of social comparison processes between the inter-agents that are involved in a common task. The majority of studies, however, investigated such kind of social interaction via one-person individual paradigms, thus not taking into account relevant information concerning interdependent participants' behavioral and neural responses. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0464-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194561PMC
October 2018
5 Reads

Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis.

BMC Neurosci 2018 Oct 17;19(1):62. Epub 2018 Oct 17.

Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.

Efficient blood supply to the brain is of paramount importance to its normal functioning and improper blood flow can result in potentially devastating neurological consequences. Cerebral blood flow in response to neural activity is intrinsically regulated by a complex interplay between various cell types within the brain in a relationship termed neurovascular coupling. The breakdown of neurovascular coupling is evident across a wide variety of both neurological and psychiatric disorders including Alzheimer's disease. Read More

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http://dx.doi.org/10.1186/s12868-018-0465-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192291PMC
October 2018
4 Reads

Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes.

BMC Neurosci 2018 Oct 16;19(1):61. Epub 2018 Oct 16.

Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, #4655 University Road, University Science Park, Changqing District, Jinan, 250355, China.

Background: Epidemiological surveys and studies with animal models have established a relationship between maternal stress and affective disorders in their offspring. However, whether maternal depression before pregnancy influences behaviour and related neurobiological mechanisms in the offspring has not been studied.

Results: A social defeat stress (SDS) maternal rat model was established using the resident-intruder paradigm with female specific pathogen-free Wistar rats and evaluated with behavioural tests. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0463-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192280PMC
October 2018
2 Reads

Effect of pulsed transcranial ultrasound stimulation at different number of tone-burst on cortico-muscular coupling.

BMC Neurosci 2018 Oct 3;19(1):60. Epub 2018 Oct 3.

Institute of Electric Engineering, Yanshan University, Qinhuangdao, 066004, Hebei, China.

Background: Pulsed transcranial ultrasound stimulation (pTUS) can modulate the neuronal activity of motor cortex and elicit muscle contractions. Cortico-muscular coupling (CMC) can serve as a tool to identify interaction between the oscillatory activity of the motor cortex and effector muscle. This research aims to explore the neuromodulatory effect of low-intensity, pTUS with different number of tone burst to neural circuit of motor-control system by analyzing the coupling relationship between motor cortex and tail muscle in mouse. Read More

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http://dx.doi.org/10.1186/s12868-018-0462-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169002PMC
October 2018
4 Reads
2.660 Impact Factor

An effort toward molecular biology of food deprivation induced food hoarding in gonadectomized NMRI mouse model: focus on neural oxidative status.

BMC Neurosci 2018 Sep 24;19(1):59. Epub 2018 Sep 24.

Department of Accounting, School of Economics and Accounting, Islamic Azad University South Tehran Branch, Tehran, Iran.

Background: Environmental uncertainty, such as food deprivation, may alter internal milieu of nervous system through various mechanisms. In combination with circumstances of stress or aging, high consumption of unsaturated fatty acids and oxygen can make neural tissues sensitive to oxidative stress (OS). For adult rats, diminished level of gonadal steroid hormones accelerates OS and may result in special behavioral manifestations. Read More

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http://dx.doi.org/10.1186/s12868-018-0461-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154416PMC
September 2018
3 Reads

Anti-inflammatory effects of minocycline are mediated by retinoid signaling.

BMC Neurosci 2018 Sep 21;19(1):58. Epub 2018 Sep 21.

Section Clinical Neurobiology, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité - University Medicine Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.

Background: Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data point towards retinoid-mediated effects of minocycline in murine brain and skin, and towards a vicious cycle of neuroinflammation which is driven by microglial activation-induced breakdown of local retinoids such as retinoic acid (RA). We therefore sought to study minocycline's anti-inflammatory effects on human microglial-like monocyte-derived cells in the context of retinoid signaling. Read More

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http://dx.doi.org/10.1186/s12868-018-0460-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151010PMC
September 2018

Transcranial focused ultrasound stimulation of motor cortical areas in freely-moving awake rats.

BMC Neurosci 2018 Sep 19;19(1):57. Epub 2018 Sep 19.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Background: Low-intensity transcranial focused ultrasound (tFUS) has emerged as a new non-invasive modality of brain stimulation with the potential for high spatial selectivity and penetration depth. Anesthesia is typically applied in animal-based tFUS brain stimulation models; however, the type and depth of anesthesia are known to introduce variability in responsiveness to the stimulation. Therefore, the ability to conduct sonication experiments on awake small animals, such as rats, is warranted to avoid confounding effects of anesthesia. Read More

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http://dx.doi.org/10.1186/s12868-018-0459-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146769PMC
September 2018

Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study.

BMC Neurosci 2018 Sep 14;19(1):56. Epub 2018 Sep 14.

Division of Physical Therapy and Division of Rehabilitation Science, Department of Rehabilitation Medicine, Medical School, University of Minnesota, 426 Church St. SE Rm 361, Minneapolis, MN, 55455, USA.

Background: Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI to extend these findings. We test the effect of tFUS on 7T BOLD fMRI signals from individual finger representations in the human primary motor cortex (M1) and connected cortical motor regions. Read More

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http://dx.doi.org/10.1186/s12868-018-0456-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137744PMC
September 2018

Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs.

BMC Neurosci 2018 Sep 12;19(1):55. Epub 2018 Sep 12.

Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.

Background: The long-term effects of psychotropic drugs are associated with the reversal of disease-related alterations through the reorganization and normalization of neuronal connections. Molecular factors that trigger drug-induced brain plasticity remain only partly understood. Doublecortin-like kinase 1 (Dclk1) possesses microtubule-polymerizing activity during synaptic plasticity and neurogenesis. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0458-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134793PMC
September 2018
3 Reads

Single-trial dynamics explain magnitude sensitive decision making.

BMC Neurosci 2018 Sep 10;19(1):54. Epub 2018 Sep 10.

School of Psychological and Cognitive Sciences, Peking University, Beijing, 100871, China.

Background: Previous research has reported or predicted, on the basis of theoretical and computational work, magnitude sensitive reaction times. Magnitude sensitivity can arise (1) as a function of single-trial dynamics and/or (2) as recent computational work has suggested, while single-trial dynamics may be magnitude insensitive, magnitude sensitivity could arise as a function of overall reward received which in turn affects the speed at which decision boundaries collapse, allowing faster responses as the overall reward received increases.

Results: Here, we review previous theoretical and empirical results and we present new evidence for magnitude sensitivity arising as a function of single-trial dynamics. Read More

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http://dx.doi.org/10.1186/s12868-018-0457-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131863PMC
September 2018

Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons.

BMC Neurosci 2018 Sep 6;19(1):52. Epub 2018 Sep 6.

The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650031, Yunnan, People's Republic of China.

Background: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1β (IL-1β), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. However, the mechanisms of how EPA regulates BDNF expression remains incompletely understood. The present study investigated the role of Akt/CREB signaling in the effect of EPA on BDNF expression and its neuroprotective effect. Read More

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http://dx.doi.org/10.1186/s12868-018-0455-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128001PMC
September 2018

The roles of aromatic residues in the glycine receptor transmembrane domain.

BMC Neurosci 2018 Sep 6;19(1):53. Epub 2018 Sep 6.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

Background: Cys-loop receptors play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular, transmembrane (TM) and intracellular domain. Each TM domain contains 4 α-helices (M1-M4) joined by loops of varying lengths. Read More

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http://dx.doi.org/10.1186/s12868-018-0454-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127993PMC
September 2018
7 Reads

Leptin: role over central nervous system in epilepsy.

BMC Neurosci 2018 Sep 5;19(1):51. Epub 2018 Sep 5.

Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Cra 24 No 63C-69, Bogotá, Colombia.

Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. Read More

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http://dx.doi.org/10.1186/s12868-018-0453-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126011PMC
September 2018

The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats.

BMC Neurosci 2018 Aug 13;19(1):49. Epub 2018 Aug 13.

Department of Biology, Rayan Center for Neuroscience and Behavior, Faculty of Science, Ferdowsi University of Mashhad, P.O. Box 9177948974, Mashhad, Iran.

Background: Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known experimental model for epileptic seizures. Read More

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http://dx.doi.org/10.1186/s12868-018-0445-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090721PMC
August 2018
1 Read

Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity.

BMC Neurosci 2018 Aug 13;19(1):50. Epub 2018 Aug 13.

Ralph H Johnson VA Medical Center, Charleston, SC, USA.

Background: Spinal cord injury (SCI) is one of the leading causes of disability and chronic pain. In SCI-induced pathology, homeostasis of the nitric oxide (NO) metabolome is lost. Major NO metabolites such as S-nitrosoglutathione (GSNO) and peroxynitrite are reported to play pivotal roles in regulating the activities of key cysteine proteases, calpains. Read More

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http://dx.doi.org/10.1186/s12868-018-0450-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090709PMC
August 2018
12 Reads

Arc protein expression after unilateral intracranial self-stimulation of the medial forebrain bundle is upregulated in specific nuclei of memory-related areas.

BMC Neurosci 2018 Aug 8;19(1):48. Epub 2018 Aug 8.

Departament de Psicobiologia i de Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autónoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.

Background: Intracranial Self-Stimulation (ICSS) of the medial forebrain bundle (MFB) is a deep brain stimulation procedure, which has a powerful enhancement effect on explicit and implicit memory. However, the downstream synaptic plasticity events of MFB-ICSS in memory related areas have not been described thoroughly. This study complements previous work studying the effect of MFB-ICSS on the expression of the activity-regulated cytoskeleton-associated (Arc) protein, which has been widely established as a synaptic plasticity marker. Read More

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http://dx.doi.org/10.1186/s12868-018-0449-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083502PMC
August 2018
1 Read

Differential modulation of human GABA-ρ1 receptor by sulfur-containing compounds structurally related to taurine.

BMC Neurosci 2018 Aug 3;19(1):47. Epub 2018 Aug 3.

Departamento de Investigación APEC, Asociación para Evitar la Ceguera en México I.A.P. Hospital Dr. Luis Sánchez Bulnes, Fernández Leal 60, Col. La Concepción Coyoacán, 04020, Mexico City, Mexico.

Background: The amino acid taurine (2-Aminoethanesulfonic acid) modulates inhibitory neurotransmitter receptors. This study aimed to determine if the dual action of taurine on GABA-ρ1R relates to its structure. To address this, we tested the ability of the structurally related compounds homotaurine, hypotaurine, and isethionic acid to modulate GABA-ρ1R. Read More

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http://dx.doi.org/10.1186/s12868-018-0448-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076408PMC
August 2018
2 Reads

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis.

BMC Neurosci 2018 Jul 28;19(1):46. Epub 2018 Jul 28.

Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, 474-8511, Japan.

Background: Alzheimer's disease (AD), the most common cause of dementia, is characterized by the progressive deposition of amyloid-β (Aβ) peptides and neurofibrillary tangles. Mouse models of Aβ amyloidosis generated by knock-in (KI) of a humanized Aβ sequence provide distinct advantages over traditional transgenic models that rely on overexpression of amyloid precursor protein (APP). In App-KI mice, three familial AD-associated mutations were introduced into the endogenous mouse App locus to recapitulate Aβ pathology observed in AD: the Swedish (NL) mutation, which elevates total Aβ production; the Beyreuther/Iberian (F) mutation, which increases the Aβ42/Aβ40 ratio; and the Arctic (G) mutation, which promotes Aβ aggregation. Read More

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http://dx.doi.org/10.1186/s12868-018-0446-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064053PMC
July 2018
2 Reads

Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer's disease with PET imaging agents F-flutemetamol and F-florbetaben.

BMC Neurosci 2018 Jul 27;19(1):45. Epub 2018 Jul 27.

Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan, 602-812, Korea.

Background: Although amyloid beta (Aβ) imaging is widely used for diagnosing and monitoring Alzheimer's disease in clinical fields, paralleling comparison between F-flutemetamol and F-florbetaben was rarely attempted in AD mouse model. We performed a comparison of Aβ PET images between F-flutemetamol and F-florbetaben in a recently developed APPswe mouse model, C57BL/6-Tg (NSE-hAPPsw) Korl.

Results: After an injection (0. Read More

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http://dx.doi.org/10.1186/s12868-018-0447-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063010PMC
July 2018
12 Reads

Relationship between ambient light and glucose metabolism in healthy subjects.

BMC Neurosci 2018 Jul 24;19(1):44. Epub 2018 Jul 24.

Department of Neuropsychiatry, Faculty of Medicine, Oita University, Idaigaoka 1-1, Hasama-machi, Yufu-City, Oita, 879-5593, Japan.

Background: Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants of the no intervention group from our previous randomized controlled trial and analyzed the association between ambient light and [F]-FDG uptake in the brain. Read More

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http://dx.doi.org/10.1186/s12868-018-0444-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057026PMC
July 2018
1 Read

Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors.

BMC Neurosci 2018 Jul 20;19(1):43. Epub 2018 Jul 20.

Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA.

Background: Light exposure induces oxidative stress, which contributes to ocular diseases of aging. Blue light provides a model for light-induced oxidative stress, lipid peroxidation and retinal degeneration in Drosophila melanogaster. In contrast to mature adults, which undergo retinal degeneration when exposed to prolonged blue light, newly-eclosed flies are resistant to blue light-induced retinal degeneration. Read More

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http://dx.doi.org/10.1186/s12868-018-0443-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053765PMC
July 2018
10 Reads

Calcium currents in striatal fast-spiking interneurons: dopaminergic modulation of Ca1 channels.

BMC Neurosci 2018 Jul 16;19(1):42. Epub 2018 Jul 16.

División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n Ciudad Universitaria, Col. Coyoacán, 04510, Ciudad de México, México.

Background: Striatal fast-spiking interneurons (FSI) are a subset of GABAergic cells that express calcium-binding protein parvalbumin (PV). They provide feed-forward inhibition to striatal projection neurons (SPNs), receive cortical, thalamic and dopaminergic inputs and are coupled together by electrical and chemical synapses, being important components of the striatal circuitry. It is known that dopamine (DA) depolarizes FSI via D-class DA receptors, but no studies about the ionic mechanism of this action have been reported. Read More

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http://dx.doi.org/10.1186/s12868-018-0441-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048700PMC
July 2018
9 Reads

Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice.

BMC Neurosci 2018 Jul 16;19(1):41. Epub 2018 Jul 16.

Department of Psychiatry, Kawasaki Medical School, Kurashiki, 701-0192, Japan.

Background: Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) are present. Several previous studies have shown that juvenile stress is implicated in the development of neuropsychiatric disorders. Read More

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http://dx.doi.org/10.1186/s12868-018-0442-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048828PMC
July 2018
2 Reads

Mapping visuospatial attention: the greyscales task in combination with repetitive navigated transcranial magnetic stimulation.

BMC Neurosci 2018 Jul 11;19(1):40. Epub 2018 Jul 11.

Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.

Background: Visuospatial attention is executed by the frontoparietal cortical areas of the brain. Damage to these areas can result in visual neglect. We therefore aimed to assess a combination of the greyscales task and repetitive navigated transcranial magnetic stimulation (rTMS) to identify cortical regions involved in visuospatial attention processes. Read More

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https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12868-018-0440-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042394PMC
July 2018
12 Reads

A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus.

BMC Neurosci 2018 Jul 6;19(1):39. Epub 2018 Jul 6.

Department of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220, Prague, Czech Republic.

Background: Tick-borne encephalitis (TBE) is the main tick-borne viral infection in Eurasia. Its manifestations range from inapparent infections and fevers with complete recovery to debilitating or fatal encephalitis. The basis of this heterogeneity is largely unknown, but part of this variation is likely due to host genetic. Read More

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http://dx.doi.org/10.1186/s12868-018-0438-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034256PMC
July 2018
5 Reads
2.660 Impact Factor

Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder.

BMC Neurosci 2018 Jul 4;19(1):38. Epub 2018 Jul 4.

Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

Background: Post-traumatic stress disorder (PTSD) is an important psychological disease that can develop following the physical experience or witnessing of traumatic events. The psychopathological response to traumatic stressors increases inflammation in the hippocampus and induces memory deficits. Melatonin (MTG) plays critical roles in circadian rhythm disorders, Alzheimer's disease, and other neurological disorders. Read More

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http://dx.doi.org/10.1186/s12868-018-0439-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032787PMC
July 2018
5 Reads

Late administration of high-frequency electrical stimulation increases nerve regeneration without aggravating neuropathic pain in a nerve crush injury.

BMC Neurosci 2018 Jun 25;19(1):37. Epub 2018 Jun 25.

Department of Neurosurgery, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sec. 4, 40705, Taichung, Taiwan.

Background: High-frequency transcutaneous neuromuscular electrical nerve stimulation (TENS) is currently used for the administration of electrical current in denervated muscle to alleviate muscle atrophy and enhance motor function; however, the time window (i.e. either immediate or delayed) for achieving benefit is still undetermined. Read More

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http://dx.doi.org/10.1186/s12868-018-0437-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020201PMC
June 2018
10 Reads

Higher levels of thyroxine may predict a favorable response to donepezil treatment in patients with Alzheimer disease: a prospective, case-control study.

BMC Neurosci 2018 Jun 22;19(1):36. Epub 2018 Jun 22.

Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, No. 130, Kai-Syuan, 2nd Road, Ling-Ya District, Kaohsiung, 802, Taiwan.

Background: Cholinergic hypothesis has been advanced as an etiology of Alzheimer disease (AD) on the basis of the presynaptic deficit found in the diseased brains, and cholinesterase inhibitors (ChEIs) are the treatment of choice for these patients. However, only about half of treatment efficacy was found. Because increasing evidence supports an extensive interrelationship between thyroid hormones (THs), cortisol level and the cholinergic system, the aim of the present study was to evaluate thyroid function and cortisol level in patients with mild to moderate AD before and after ChEIs treatment, and to identify possible variations in response. Read More

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http://dx.doi.org/10.1186/s12868-018-0436-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013955PMC
June 2018
8 Reads

Neural correlates of free recall of "famous events" in a "hypermnestic" individual as compared to an age- and education-matched reference group.

BMC Neurosci 2018 Jun 19;19(1):35. Epub 2018 Jun 19.

Center for Cognitive Sciences, University of Bremen, Bremen, Germany.

Background: Memory performance of an individual (within the age range: 50-55 years old) showing superior memory abilities (protagonist PR) was compared to an age- and education-matched reference group in a historical facts ("famous events") retrieval task.

Results: Contrasting task versus baseline performance both PR and the reference group showed fMRI activation patterns in parietal and occipital brain regions. The reference group additionally demonstrated activation patterns in cingulate gyrus, whereas PR showed additional widespread activation patterns comprising frontal and cerebellar brain regions. Read More

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http://dx.doi.org/10.1186/s12868-018-0435-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006772PMC
June 2018
3 Reads

Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields.

BMC Neurosci 2018 Jun 13;19(1):34. Epub 2018 Jun 13.

Stroke Unit, Azienda Socio Sanitaria Territoriale "Spedali Civili", "Spedali Civili" Hospital, Piazza Spedali Civili 1, 25123, Brescia, Italy.

Background: Non-depolarizing magnetic fields, like low frequency-pulsed electromagnetic fields (LF-PEMFs) have shown the ability to modulate living structures, principally by influencing synaptic activity and ion channels on cellular membranes. Recently, the CTU Mega 20 device was presented as a molecular accelerator, using energy up to 200 J and providing high-power (2 Tesla) pulsating fields with a water-repulsive (diamagnetic) action and tissue biostimulation. We tested the hypothesis that LF-PEMFs could modulate long-term corticospinal excitability in healthy brains by applying CTU Mega 20. Read More

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http://dx.doi.org/10.1186/s12868-018-0434-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998451PMC
June 2018
2 Reads
2.660 Impact Factor

Altered functional connectivity of the default mode network by glucose loading in young, healthy participants.

BMC Neurosci 2018 May 31;19(1):33. Epub 2018 May 31.

Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.

Background: The functional connectivity of the default mode network (DMN) decreases in patients with Alzheimer's disease (AD) as well as in patients with type 2 diabetes mellitus (T2DM). Altered functional connectivity of the DMN is associated with cognitive impairment. T2DM is a known cause of cognitive dysfunction and dementia in the elderly, and studies have established that T2DM is a risk factor for AD. Read More

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http://dx.doi.org/10.1186/s12868-018-0433-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984391PMC
May 2018
4 Reads

Extremely low frequency electromagnetic field exposure and restraint stress induce changes on the brain lipid profile of Wistar rats.

BMC Neurosci 2018 May 21;19(1):31. Epub 2018 May 21.

Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Escolar s/n, Ciudad Universitaria, C.P. 04510, Mexico City, Mexico.

Background: Exposure to electromagnetic fields can affect human health, damaging tissues and cell homeostasis. Stress modulates neuronal responses and composition of brain lipids. The aim of this study was to evaluate the effects of chronic extremely low frequency electromagnetic field (ELF-EMF) exposure, restraint stress (RS) or both (RS + ELF-EMF) on lipid profile and lipid peroxidation in Wistar rat brain. Read More

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http://dx.doi.org/10.1186/s12868-018-0432-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963128PMC
May 2018
2 Reads

Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis.

BMC Neurosci 2018 May 21;19(1):32. Epub 2018 May 21.

Department of Neurology, Medical University of Innsbruck, Innrain 66, G2, 6020, Innsbruck, Austria.

Background: The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs). A connection between the abnormal accumulation of α-synuclein in GCIs and disease initiation and progression has been postulated. Mechanisms involved in the formation of GCIs are unclear. Read More

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http://dx.doi.org/10.1186/s12868-018-0431-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963177PMC
May 2018
2 Reads
2.660 Impact Factor