2,196 results match your criteria BMC Neurology[Journal]


GABA receptor encephalitis in a patient diagnosed with amyotrophic lateral sclerosis.

BMC Neurol 2019 Mar 14;19(1):41. Epub 2019 Mar 14.

German Center for Neurodegenerative Diseases (DZNE) Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Background: In 2010 the spectrum of known antigens in autoimmune encephalitis has been expanded by GABA receptors. Until now over 80 patients with GABA receptor encephalitis have been described. We report the occurrence of GABA receptor antibodies in a patient with clinically diagnosed amyotrophic lateral sclerosis (ALS). Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1269-7DOI Listing
March 2019
1 Read

Guided Self-rehabilitation Contract vs conventional therapy in chronic stroke-induced hemiparesis: NEURORESTORE, a multicenter randomized controlled trial.

BMC Neurol 2019 Mar 12;19(1):39. Epub 2019 Mar 12.

EA 7377 BIOTN, Laboratoire Analyse et Restauration du Mouvement, Université Paris Est Créteil (UPEC), F-94010, Créteil, France.

Background: After discharge from hospital following a stroke, prescriptions of community-based rehabilitation are often downgraded to "maintenance" rehabilitation or discontinued. This classic therapeutic behavior stems from persistent confusion between lesion-induced plasticity, which lasts for the first 6 months essentially, and behavior-induced plasticity, of indefinite duration, through which intense rehabilitation might remain effective. This prospective, randomized, multicenter, single-blind study in subjects with chronic stroke-induced hemiparesis evaluates changes in active function with a Guided Self-rehabilitation Contract vs conventional therapy alone, pursued for a year. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1257-yDOI Listing
March 2019
1 Read

Effect of early supported discharge after stroke on patient reported outcome based on the Swedish Riksstroke registry.

BMC Neurol 2019 Mar 12;19(1):40. Epub 2019 Mar 12.

Department of Public Health and Clinical Medicine, Umeå University, S-901 87, Umeå, Sweden.

Background: The efficacy of early supported discharge (ESD) has not been tested in current stroke care setting, which provide relatively short hospital stays, access to hyper-acute therapies and early carotid stenosis interventions. This study aimed to compare patient-reported outcome measures (PROM) among patients with stroke that received modern stroke unit care with or without ESD.

Methods: Observational study of 30,232 patients with first-ever stroke registered in the Riksstroke registry in Sweden, between 1 January 2010 and 31 December 2013. Read More

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http://dx.doi.org/10.1186/s12883-019-1268-8DOI Listing

The therapeutic value of cerebrospinal fluid ctDNA detection by next-generation sequencing for meningeal carcinomatosis: a case report.

BMC Neurol 2019 Mar 9;19(1):38. Epub 2019 Mar 9.

Department of Neurology, The Second Hospital of Hebei Medical University, No 215, Peace Road, Shijiazhuang, China.

Background: It is usually very complicated to treat meningeal carcinomatosis, and it is important to treat it as soon as possible.

Case Presentation: The 19-Del mutation was found in the exon for the epidermal growth factor receptor gene in the pleural effusion of a patient on March 11th, 2015. He took 250 mg of oral gefitinib once a day for 11 months beginning in December of 2015. Read More

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http://dx.doi.org/10.1186/s12883-019-1266-xDOI Listing
March 2019
1 Read

Influence of different rehabilitative aerobic exercise programs on (anti-) inflammatory immune signalling, cognitive and functional capacity in persons with MS - study protocol of a randomized controlled trial.

BMC Neurol 2019 Mar 8;19(1):37. Epub 2019 Mar 8.

Deparment of Neurology, Kliniken-Valens, Rehabilitationsklinik-Valens, Taminaplatz 1, 7317, Valens, Switzerland.

Background: Studies have shown positive effects of therapeutic exercise on motor- and cognitive function as well as on psychosocial outcomes in persons with multiple sclerosis (MS). A reduction of inflammatory stress through physical exercise has been suspected as one key mechanism, mediating the positive effects of exercise in the context of MS. The primary objective of this trial is to investigate the acute and chronic effects of different exercise modalities on (anti-)inflammatory immune signalling as well as on cognitive and functional capacity in persons with MS. Read More

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http://dx.doi.org/10.1186/s12883-019-1267-9DOI Listing
March 2019
2 Reads

Effectiveness of rituximab in neuromyelitis optica: a meta-analysis.

BMC Neurol 2019 Mar 6;19(1):36. Epub 2019 Mar 6.

Department of Neurology, Gansu Provincial Hospital, No. 204 of Donggang West Road, Lanzhou City, Gansu province, 730000, People's Republic of China.

Background: Neuromyelitis optica (NMO) is a severe inflammatory autoimmune disorder of the central nervous system and often results in paralysis or blindness. Rituximab (RTX) is a mouse-human chimeric monoclonal antibody specific for the CD20 antigen on B lymphocytes and used to treat many autoimmune diseases. Disability and relapses were measured using the Expanded Disability Status Scale (EDSS) and annualized relapse rate (ARR) ratio to evaluate the effectiveness of RTX. Read More

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http://dx.doi.org/10.1186/s12883-019-1261-2DOI Listing
March 2019
1 Read
2.040 Impact Factor

Doxycycline for the treatment of nodding syndrome (DONS); the study protocol of a phase II randomised controlled trial.

BMC Neurol 2019 Mar 6;19(1):35. Epub 2019 Mar 6.

Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, OX3 7FZ, UK.

Background: Nodding syndrome is a poorly understood neurological disorder of unknown aetiology, affecting several thousand children in Africa. There has been a consistent epidemiological association with infection by the filarial parasite, Onchocerca volvulus and antibodies to leiomodin and DJ-1, cross-reacting with O.volvulus proteins, have been reported. Read More

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http://dx.doi.org/10.1186/s12883-019-1256-zDOI Listing

Progressive stenosis and radiological findings of vasculitis over the entire internal carotid artery in moyamoya vasculopathy associated with graves' disease: a case report and review of the literature.

BMC Neurol 2019 Mar 2;19(1):34. Epub 2019 Mar 2.

Department of Neurology, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi, Japan.

Background: Moyamoya vasculopathy (MMV) associated with Graves' disease (GD) is a rare condition resulting in ischemic stroke accompanied by thyrotoxicity. Radiological findings of vasculitis have been reported in the walls of distal internal carotid arteries (ICAs) in these patients; however, no reports have described in detail the processes of progression of the lesions in the proximal ICA. Moreover, treatments to prevent recurrence of ischemic stroke and progression of MMV have not yet been sufficiently elucidated. Read More

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http://dx.doi.org/10.1186/s12883-019-1262-1DOI Listing
March 2019
2 Reads

Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis.

BMC Neurol 2019 Feb 28;19(1):33. Epub 2019 Feb 28.

Mount Sinai Medical Center, New York City, USA.

Background: Although patients with dementia frequently experience neuropsychological symptoms (NPS) such as agitation, which profoundly impacts patients, caregivers, and the healthcare system, few studies have evaluated the associated burden of agitation or agitation-related symptoms in dementia.

Methods: This retrospective analysis of claims data from the Truven Health MarketScan® database (2012-2015) compared clinical characteristics, treatment patterns, healthcare resource utilization, and costs among patients with dementia with behavioral disturbances (BD) versus patients with dementia without BD. Existing BD diagnosis codes 294. Read More

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http://dx.doi.org/10.1186/s12883-019-1260-3DOI Listing
February 2019

COL6A1 mutation leading to Bethlem myopathy with recurrent hematuria: a case report.

BMC Neurol 2019 Feb 26;19(1):32. Epub 2019 Feb 26.

Department of Neurology, Affiliated Qianfoshan Hospital of Shandong University, NO.16766, Jingshi Road, Shandong, Jinan, 250014, CN, China.

Background: Collagen VI-related myopathies are a spectrum of muscular diseases with features of muscle weakness and atrophy, multiple contractures of joints, distal hyperextensibility, severe respiratory dysfunction and cutaneous alterations, attributable to mutations in the COL6A1, COL6A2, and COL6A3 genes. However, no case of collagen VI mutations with hematuria has been reported. We report a 14-year-old boy who had both Bethlem myopathy and recurrent hematuria and who carried a known de novo COL6A1 missense mutation c. Read More

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http://dx.doi.org/10.1186/s12883-019-1263-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390614PMC
February 2019

rs1234313 and rs45454293 are risk factors of cerebral arterial thrombosis, large artery atherosclerosis, and carotid plaque in the Han Chinese population: a case-control study.

BMC Neurol 2019 Feb 23;19(1):31. Epub 2019 Feb 23.

Department of Neurology, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, People's Republic of China.

Background: Ischemic stroke is a leading cause of mortality and morbidity worldwide. Stenosis or blockage of an artery from atherosclerosis can cause insufficient cerebral blood supply, which leads to ischemic stroke. It has been reported that the polymorphisms of TNFSF4 (tumor necrosis factor super family member 4) are associated with multiple autoimmune diseases. Read More

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http://dx.doi.org/10.1186/s12883-019-1259-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387510PMC
February 2019

Establishment and utility assessment of posterior reversible encephalopathy syndrome early warning scoring (PEWS) scale establishment and utility assessment of PEWS scale.

BMC Neurol 2019 Feb 21;19(1):30. Epub 2019 Feb 21.

Department of Pediatrics, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China.

Background: Posterior reversible encephalopathy syndrome (PRES) is a complication that occurs during various diseases' treatment. Imaging examination is the gold standard for diagnosis. PRES frequently occurrence in patients with hematological malignancies results in poorer prognosis and higher mortality. Read More

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http://dx.doi.org/10.1186/s12883-019-1247-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385440PMC
February 2019
2 Reads

A case of surgically-associated anti GQ1b antibody syndrome accompanied by saccadic ping pong gaze.

BMC Neurol 2019 Feb 19;19(1):28. Epub 2019 Feb 19.

Department of Neurology, Harrison International Peace Hospital, 2 Renmin Zhong Road, Taocheng District, Hengshui, 050000, Hebei, China.

Background: Periodic alternating ping-pong gaze (PPG) is a rare disease with few reports. To our knowledge, there was no report on anti GQ1b antibody syndrome accompanied by PPG. This paper reported a case of anti GQ1b antibody syndrome with Bickerstaff's Encephalitis (BBE) overlapping classic Guillain-Barre Syndrome (GBS) after aortic valve replacement, accompanied by an excessive PPG in the course of diagnosis and treatment, this was indeed rarely. Read More

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http://dx.doi.org/10.1186/s12883-019-1258-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380021PMC
February 2019
2 Reads

Promoting faster pathways to surgery: a clinical audit of patients with refractory epilepsy.

BMC Neurol 2019 Feb 19;19(1):29. Epub 2019 Feb 19.

Australian Institute of Health Innovation, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Background: Individuals with epilepsy who cannot be adequately controlled with anti-epileptic drugs, refractory epilepsy, may be suitable for surgical treatment following detailed assessment. This is a complex process and there are concerns over delays in referring refractory epilepsy patients for surgery and subsequent treatment. The aim of this study was to explore the different patient pathways, referral and surgical timeframes, and surgical and medical treatment options for refractory epilepsy patients referred to two Tertiary Epilepsy Clinics in New South Wales, Australia. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1255-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381714PMC
February 2019
5 Reads

Autism, spectrum or clusters? An EEG coherence study.

BMC Neurol 2019 Feb 14;19(1):27. Epub 2019 Feb 14.

Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Enders 107, Boston, MA, 02115, USA.

Background: Autism prevalence continues to grow, yet a universally agreed upon etiology is lacking despite manifold evidence of abnormalities especially in terms of genetics and epigenetics. The authors postulate that the broad definition of an omnibus 'spectrum disorder' may inhibit delineation of meaningful clinical correlations. This paper presents evidence that an objectively defined, EEG based brain measure may be helpful in illuminating the autism spectrum versus subgroups (clusters) question. Read More

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http://dx.doi.org/10.1186/s12883-019-1254-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375153PMC
February 2019
1 Read

Optimizing early enteral nutrition in severe stroke (OPENS): protocol for a multicentre randomized controlled trial.

BMC Neurol 2019 Feb 12;19(1):24. Epub 2019 Feb 12.

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.

Background: Malnutrition is one of the crucial factors associated with poor prognosis in critical ill patients, yet a significant evidence gap surrounds the management of initial enteral feeding in severe stroke. The Optimizing Early Enteral Nutrition in Severe Stroke (OPENS) trial will compare a strategy of modified full enteral nutrition (EN) (standard full EN in conjunction with prokinetic drug) and a strategy of permissive underfeeding (40 to 60% of estimated caloric requirements) with standard full EN (advancement to target nutrition goals) in patients with severe stroke.

Methods: The OPENS trial is a multicenter randomized controlled study. Read More

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http://dx.doi.org/10.1186/s12883-019-1253-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371599PMC
February 2019
2.040 Impact Factor

Early risk assessment of circulating endothelial progenitor cells and plasma stromal cell-derived factor-1 for nondisabling ischemic cerebrovascular events.

BMC Neurol 2019 Feb 12;19(1):22. Epub 2019 Feb 12.

Department of Neurology, Second Peoples Hospital of Chengdu, Chengdu, 610000, Sichuan Province, China.

Background: Endothelial progenitor cells (EPCs) play an important role in ischemic stroke. However, there are few studies on the relationship between EPC and nondisabling ischemic cerebrovascular events. Our aim was to investigate the association of EPCs and SDF-1 (serum stromal cell-derived factor-1) with NICE (nondisabling ischemic cerebrovascular events). Read More

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http://dx.doi.org/10.1186/s12883-019-1250-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371535PMC
February 2019

Stroke prevention in patients with acute ischemic stroke and atrial fibrillation in Germany - a cross sectional survey.

BMC Neurol 2019 Feb 12;19(1):25. Epub 2019 Feb 12.

Department of Neurology, University Hospital Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.

Background: Atrial fibrillation (AF) is present in 15-20% of patients with acute ischemic stroke. Oral anticoagulation reduces the risk of AF-related recurrent stroke but clinical guideline recommendations are rather vague regarding its use in the acute phase of stroke. We aimed to assess the current clinical practice of medical stroke prevention in AF patients during the acute phase of ischemic stroke. Read More

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http://dx.doi.org/10.1186/s12883-019-1249-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371606PMC
February 2019

Mixed cerebrovascular disease in an elderly patient with mixed vascular risk factors: a case report.

BMC Neurol 2019 Feb 12;19(1):26. Epub 2019 Feb 12.

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.

Background: Mixed cerebrovascular disease is a diagnostic entity that presents with hemorrhagic and ischemic stroke clinically and/or subclinically. Here, we report a patient with mixed vascular risk factors, who presented with multiple intracerebral hemorrhages and a simultaneously occurring cerebral infarction with hemorrhagic transformation.

Case Presentation: A 63-year-old male with no history of trauma or prior neurological disease presented with a sudden onset of weakness in his right limbs, followed by an episode of focal seizure without impaired awareness. Read More

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http://dx.doi.org/10.1186/s12883-019-1248-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371517PMC
February 2019
4 Reads

The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis.

BMC Neurol 2019 Feb 12;19(1):23. Epub 2019 Feb 12.

Department of Neurology, Harvard Medical School, Boston, MA, USA.

Background: Serum hematological indices such as the neutrophil-lymphocyte ratio (NLR) or monocyte-lymphocyte ratio (MLR) have been used as biomarkers of pathogenic inflammation and prognostication in multiple areas of medicine; recent evidence shows correlation with psychological parameters as well.

Objectives/aims: To characterize clinical, neuroimaging, and psycho-neuro-immunological associations with NLR and MLR in persons with multiple sclerosis (MS).

Methods: We identified a large cohort of clinically well-defined patients from our longitudinal database that included MS-related outcomes, disease-modifying therapy, patient-reported outcome (PRO) measures, and quantified cerebral MRI at 1. Read More

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http://dx.doi.org/10.1186/s12883-019-1245-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371437PMC
February 2019

Assessment of fatigability in patients with spinal muscular atrophy: development and content validity of a set of endurance tests.

BMC Neurol 2019 Feb 9;19(1):21. Epub 2019 Feb 9.

Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, PO Box 85090, KB 02.056.0, 3508, AB, Utrecht, The Netherlands.

Background: Fatigability has emerged as an important dimension of physical impairment in patients with Spinal Muscular Atrophy (SMA). At present reliable and valid outcome measures for both mildly and severely affected patients are lacking. Therefore the primary aim of this study is the development of clinical outcome measures for fatigability in patients with SMA across the range of severity. Read More

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http://dx.doi.org/10.1186/s12883-019-1244-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368708PMC
February 2019
7 Reads

Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial.

BMC Neurol 2019 Feb 9;19(1):20. Epub 2019 Feb 9.

Cognitive Neurology and Alzheimer's Disease Research Centre, Parkwood Institute - Main Building, Room A230, 550, Wellington Road, London, Ontario, N6G 0A7, Canada.

Background: Currently there are no disease-modifying treatments for Parkinson's disease dementia (PDD), a condition linked to aggregation of the protein α-synuclein in subcortical and cortical brain areas. One of the leading genetic risk factors for Parkinson's disease is being a carrier in the gene for β-Glucocerebrosidase (GCase; gene name GBA1). Studies in cell culture and animal models have shown that raising the levels of GCase can decrease levels of α-synuclein. Read More

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http://dx.doi.org/10.1186/s12883-019-1252-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368728PMC
February 2019
1 Read

Antibody-LGI 1 autoimmune encephalitis manifesting as rapidly progressive dementia and hyponatremia: a case report and literature review.

BMC Neurol 2019 Feb 7;19(1):19. Epub 2019 Feb 7.

Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.

Background: Anti leucine-rich glioma inactivated 1 (LGI1) encephalitis is a rare autoimmune encephalitis (AE), characterized by acute or subacute cognitive impairment, faciobrachial dystonic seizures, psychiatric disturbances and hyponatremia. Antibody-LGI 1 autoimmune encephalitis (anti-LGI1 AE) has increasingly been recognized as a primary autoimmune disorder with favorable prognosis and response to treatment.

Case Presentation: Herein, we reported a male patient presenting as rapidly progressive dementia and hyponatremia. Read More

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http://dx.doi.org/10.1186/s12883-019-1251-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366039PMC
February 2019
2 Reads
2.040 Impact Factor

Patterns of traumatic brain injury and six-month neuropsychological outcomes in Uganda.

BMC Neurol 2019 Feb 4;19(1):18. Epub 2019 Feb 4.

Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda.

Background: Traumatic brain injuries in Uganda are on the increase, however little is known about the neuropsychological outcomes in survivors. This study characterized patients with traumatic brain injury (TBI) and the associated six-month neuropsychological outcomes in a Ugandan tertiary hospital.

Methods: Patients admitted at Mulago Hospital with head injury from November 2015 to April 2016 were prospectively enrolled during admission and followed up at six months after discharge to assess cognition, posttraumatic stress symptoms (PTSS), depression symptoms and physical disability. Read More

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http://dx.doi.org/10.1186/s12883-019-1246-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360708PMC
February 2019
3 Reads

Association between autonomic dysfunction and olfactory dysfunction in Parkinson's disease in southern Chinese.

BMC Neurol 2019 Feb 2;19(1):17. Epub 2019 Feb 2.

Department of Neurology, East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China.

Background: The aim was to investigate the autonomic dysfunction between Parkinson's disease (PD) patients with olfactory dysfunction and PD patients without olfactory dysfunction in southern Chinese population.

Methods: Fifty-six PD patients with olfactory dysfunction and 44 patients without olfactory dysfunction were included. All patients were evaluated by Sniffin' sticks (SS-16), scales for outcomes in Parkinson's disease-autonomic questionnaire, Hamilton anxiety rating scale and Hamilton depression rating scale RESULTS: The score of subpart of gastrointestinal symptoms and subpart of urinary symptoms were different in two groups (gastrointestinal symptoms: p value: 0. Read More

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http://dx.doi.org/10.1186/s12883-019-1243-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359856PMC
February 2019
4 Reads
2.040 Impact Factor

Correction to: Concordance analysis of microarray studies identifies representative gene expression changes in Parkinson's disease: a comparison of 33 human and animal studies.

BMC Neurol 2019 Jan 30;19(1):16. Epub 2019 Jan 30.

Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, UK.

Following publication of the original article [1], the authors reported the following errors on their article. Read More

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http://dx.doi.org/10.1186/s12883-019-1240-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354380PMC
January 2019
1 Read

Acute alcohol intoxication may cause delay in stroke treatment - case reports.

BMC Neurol 2019 Jan 29;19(1):14. Epub 2019 Jan 29.

Department of Neurology, Faculty of Medicine, University of Debrecen, Moricz Zs. krt 22, Debrecen, 4032, Hungary.

Background: The signs and symptoms of acute alcohol intoxication resemble those of vertebrobasilar stroke. Due to their shared symptoms including double vision, nystagmus, dysarthria, and ataxia, the differential diagnosis of alcohol intoxication and vertebrobasilar stroke may pose a challenge. Moreover, if alcohol intoxication and stroke occur simultaneously, the signs and symptoms of stroke may be attributed to the effects of alcohol, leading to delayed stroke diagnosis and failure to perform reperfusion therapy. Read More

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http://dx.doi.org/10.1186/s12883-019-1241-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350361PMC
January 2019
1 Read

One-year versus five-year hospital readmission after ischemic stroke and TIA.

BMC Neurol 2019 Jan 29;19(1):15. Epub 2019 Jan 29.

Department of Clinical Medicine, University of Bergen, Jonas Lies veg 87, N-5021, Bergen, Norway.

Background: The burden of hospital readmission after stroke is substantial, but little knowledge exists on factors associated with long-term readmission after stroke. In a cohort comprising patients with ischemic stroke and transient ischemic attack (TIA), we examined and compared factors associated with readmission within 1 year and first readmission during year 2-5.

Methods: Patients with ischemic stroke or TIA who were discharged alive between July 2007 and October 2012, were followed for 5 years by review of medical charts. Read More

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http://dx.doi.org/10.1186/s12883-019-1242-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352360PMC
January 2019
8 Reads

Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population.

BMC Neurol 2019 Jan 22;19(1):13. Epub 2019 Jan 22.

Department of Pharmacy, Shandong Provincial Hospital affiliated to Shandong University, Jinan, 250100, China.

Background: Epilepsy is one of the most common chronic disabling neurologic diseases. The purpose of our study was to investigate whether there is an association between t-PA (tissue plasminogen activator, rs2020918 and rs4646972), PAI-1 (plasminogen activator inhibitor 1, rs1799768) polymorphisms and susceptibility to temporal lobe epilepsy (TLE) in Chinese Han population.

Method: One hundred and twenty-one cases of patients who were diagnosed as TLE and 146 normal controls were enrolled and the genotypes of t-PA and PAI-1 were detected by polymerase chain reaction-ligase detection reaction (PCR-LDR) method after the genomic DNA being extracted from peripheral blood. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1239-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343363PMC
January 2019
8 Reads

A qualitative study of the communication and information needs of people with learning disabilities and epilepsy with physicians, nurses and carers.

BMC Neurol 2019 Jan 19;19(1):12. Epub 2019 Jan 19.

School of Nursing and Midwifery, Department of Mental Health, University of Cape Coast, Cape Coast, Ghana.

Background: Living with a chronic condition such as epilepsy can have a debilitating effect on the individual and their carers. Managing epilepsy among people with learning disabilities may present a challenge because of limited communication and may require a multidisciplinary approach. The study investigated the communication and information needs of people with learning disabilities with epilepsy and their physicians, nurses and carers. Read More

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http://dx.doi.org/10.1186/s12883-018-1235-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339405PMC
January 2019
2 Reads

Futile reperfusion and predicted therapeutic benefits after successful endovascular treatment according to initial stroke severity.

BMC Neurol 2019 Jan 15;19(1):11. Epub 2019 Jan 15.

Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: Futile reperfusion (poor functional status despite successful reperfusion) was observed in up to 67% of patients enrolled in recent endovascular treatment (EVT) clinical trials. We investigated the impact of baseline stroke severity on both futile reperfusion and therapeutic benefit of successful EVT.

Methods: Using a prospective multicenter stroke registry, we identified consecutive ischemic stroke patients with anterior circulation large artery occlusion, who were reperfused successfully by EVT (Thrombolysis in Cerebral Infarction grade 2b-3). Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1237-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332890PMC
January 2019
9 Reads

Epidemiology of non-traumatic spinal cord injury in Uganda: a single center, prospective study with MRI evaluation.

BMC Neurol 2019 Jan 15;19(1):10. Epub 2019 Jan 15.

Department of Radiology and Biomedical Imaging ,Yale School of Medicine, Yale University, New Haven, CT, USA.

Background: A few reliable national data concerning the etiology of non-traumatic spinal cord injury (SCI) in sub-Sahara Africa exists, mainly because of the limitations of diagnostic imaging. These are both expensive and mostly unavailable in several resource-limited settings. Only a few studies have employed the magnetic resonance imaging (MRI) in documenting non-traumatic SCI and most of these studies are from South Africa. Read More

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https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-
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http://dx.doi.org/10.1186/s12883-019-1236-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332574PMC
January 2019
4 Reads

Spinocerebellar ataxia type 31 associated with REM sleep behavior disorder: a case report.

BMC Neurol 2019 Jan 11;19(1). Epub 2019 Jan 11.

Department of Neurology, University of Yamanashi, 1110 Shimokatou, Yamanashi, 409-3898, Japan.

Background: Spinocerebellar ataxia type 31 (SCA 31) is a slowly progressive neurodegenerative disorder characterized by pure cerebellar ataxia. Unlike other CAG repeat diseases, sleep-related problems have not been reported in patients with SCA 31 so far.

Case Presentation: A 67-year-old woman was admitted to our hospital with dysarthria and gait disturbance after onset age of 62 years. Read More

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http://dx.doi.org/10.1186/s12883-019-1238-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329112PMC
January 2019
9 Reads

Correction to: Time spent lying, sitting, and upright during hospitalization after stroke: a prospective observation study.

BMC Neurol 2019 Jan 11;19(1). Epub 2019 Jan 11.

Department of Neuromedicine and Movement Science, Faculty of Medicine and health science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.

The original version of this article. Read More

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http://dx.doi.org/10.1186/s12883-018-1226-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329179PMC
January 2019
1 Read

Does all single infarction have lower risk of stroke recurrence than multiple infarctions in minor stroke?

BMC Neurol 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Single acute infarction (SAI) usually had lower risk of stroke recurrence than multiple acute infarctions (MAIs) in minor stroke. To evaluate whether all SAI had lower risk of stroke recurrence than MAIs in minor stroke.

Methods: We derived data from the imaging subgroup of the Clopidogrel in High-risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial. Read More

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http://dx.doi.org/10.1186/s12883-018-1215-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325885PMC
January 2019
14 Reads
2.040 Impact Factor

A randomized placebo-controlled trial of delayed-release dimethyl fumarate in patients with relapsing-remitting multiple sclerosis from East Asia and other countries.

BMC Neurol 2019 Jan 7;19(1). Epub 2019 Jan 7.

Biogen, Cambridge, MA, USA.

Background: Delayed-release dimethyl fumarate (DMF) has demonstrated efficacy and a favorable benefit-risk profile in phase 2 and 3 studies that enrolled predominantly white patients with relapsing-remitting multiple sclerosis (RRMS). In this study (APEX, Part I), we evaluated the efficacy/safety outcomes of DMF in a predominantly East Asian population of patients with RRMS.

Methods: In this 24-week, randomized, double-blind, placebo-controlled phase 3 study, 225 patients, 142 of which were East Asian (63. Read More

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http://dx.doi.org/10.1186/s12883-018-1220-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322309PMC
January 2019
4 Reads
2.040 Impact Factor

Noninvasive molecular diagnosis of craniopharyngioma with MRI-based radiomics approach.

BMC Neurol 2019 Jan 7;19(1). Epub 2019 Jan 7.

Department of Electronic Engineering, Fudan University, Shanghai, China.

Background: Frequent somatic mutations of BRAF and CTNNB1 were identified in both histological subtypes of craniopharyngioma (adamantinomatous and papillary) which shed light on target therapy to cure this oncogenic disease. The aim of this study was to investigate the noninvasive MRI-based radiomics diagnosis to detect BRAF and CTNNB1 mutations in craniopharyngioma patients.

Methods: Forty-four patients pathologically diagnosed as adamantinomatous craniopharyngioma (ACP) or papillary craniopharyngioma (PCP) were retrospectively studied. Read More

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http://dx.doi.org/10.1186/s12883-018-1216-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322318PMC
January 2019
10 Reads

Gout and the risk of Parkinson's disease in older adults: a study of U.S. Medicare data.

BMC Neurol 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of Medicine at School of Medicine, University of Alabama at Birmingham, Faculty Office Tower 805B, 510 20th Street S, Birmingham, AL, 35294-0022, USA.

Background: In the presence of limited available data, our objective was to assess the association of gout with the risk of incident Parkinson's disease (PD) in adults 65 years or older.

Methods: We used the 5% random sample of Medicare claims data from 2006 to 2012 to examine the association of gout with incident PD. The multivariable Cox regression model adjusted for demographics, comorbidity, and common cardiovascular disease and gout medications. Read More

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http://dx.doi.org/10.1186/s12883-018-1234-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321725PMC
January 2019
3 Reads

Stroke risk after transient ischemic attack in a Norwegian prospective cohort.

BMC Neurol 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, P.O.Box 8905, N-7491, Trondheim, Norway.

Background: Transient ischemic attack (TIA) is a risk factor of stroke. Modern treatment regimens and changing risk factors in the population justify new estimates of stroke risk after TIA, and evaluation of the recommended ABCD stroke risk score.

Methods: From October, 2012, to July, 2014, we performed a prospective, multicenter study in Central Norway, enrolling patients with a TIA within the previous 2 weeks. Read More

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http://dx.doi.org/10.1186/s12883-018-1225-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317188PMC
January 2019
8 Reads

Changes in background electroencephalographic activity in benign childhood epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study.

BMC Neurol 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Background: Several neuroimaging studies have reported neurophysiological alterations in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. Read More

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http://dx.doi.org/10.1186/s12883-018-1228-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317234PMC
January 2019
9 Reads

Quantitative clinical and autoimmune assessments in stiff person syndrome: evidence for a progressive disorder.

BMC Neurol 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Neurology, Thomas Jefferson University, Philadelphia, USA.

Background: Stiff Person Syndrome (SPS) is an under-diagnosed disorder that affects mobility and the quality of life of affected patients. The aim of the study is to describe the natural history of SPS, the extent of accumulated disability and the associated clinical and immunological features in patients followed for up to 8 years in a single center.

Methods: Our collective cohort included 57 SPS patients. Read More

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http://dx.doi.org/10.1186/s12883-018-1232-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317182PMC
January 2019
2 Reads

Myasthenia gravis following human papillomavirus vaccination: a case report.

BMC Neurol 2018 Dec 28;18(1):222. Epub 2018 Dec 28.

Department of Neurology, Chonbuk National University School of Medicine, Jeonju, 54896, Republic of Korea.

Background: Myasthenia gravis (MG), an autoimmune neuromuscular disorder, occurs owing to autoantibodies against acetylcholine receptors. MG symptoms can be triggered by various vaccines. Many studies have evaluated the safety and adverse events of the human papillomavirus (HPV) vaccine. Read More

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http://dx.doi.org/10.1186/s12883-018-1233-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309058PMC
December 2018
11 Reads

First three cases of scalp temperature change in symptomatic areas affected by nummular headache: a case report.

BMC Neurol 2018 Dec 28;18(1):223. Epub 2018 Dec 28.

Department of Encephalopathy, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 530023, China.

Background: Nummular headache is a distinct headache disorder characterized by a rounded or elliptical symptomatic area that is typically 2 to 6 cm in diameter and does not change in shape or size with time. Although the pathomechanism is still not clear, nummular headache is thought to be a primary headache disorder. To date, more than 250 cases have been reported; the symptoms of this disease vary, but no cases with scalp temperature changes in the symptomatic areas have been reported yet. Read More

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http://dx.doi.org/10.1186/s12883-018-1231-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309064PMC
December 2018
3 Reads

Hypotension and bradycardia, a serious adverse effect of piribedil, a case report and literature review.

BMC Neurol 2018 Dec 27;18(1):221. Epub 2018 Dec 27.

Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong province, China.

Background: Dopamine agonists (DAs) are efficacious for the treatment of motor and nonmotor symptoms in patients with Parkinson's disease (PD). The treatment of PD with DAs is often complicated by adverse drug reactions (ADRs) of dopaminergic and non-dopaminergic origins. The DA piribedil is widely used in Asian, European, and Latin American countries; therefore, its ADRs are pertinent to clinicians. Read More

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http://dx.doi.org/10.1186/s12883-018-1230-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307137PMC
December 2018
1 Read
2.040 Impact Factor

Subclinical Leber's hereditary optic neuropathy with pediatric acute spinal cord onset: more than meets the eye.

BMC Neurol 2018 Dec 27;18(1):220. Epub 2018 Dec 27.

Department of Pathophysiology and Transplantation, Dino Ferrari Centre, University of Milan, Milan, Italy.

Background: Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by visual loss consequent to optic nerve atrophy. In some cases, LHON is associated with heterogeneous neurological extraocular manifestations and is referred to as "Leber plus disease"; rarely it is associated with a multiple sclerosis (MS)-like syndrome known as Harding disease, but no pediatric extraocular acute spinal onset is reported.

Case Presentation: We describe the case of a 5-year-old girl carrying the G3460A mtDNA mutation who was referred to clinical examination for bilateral upper and lower limb weakness with no sign of optic neuropathy. Read More

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http://dx.doi.org/10.1186/s12883-018-1227-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307307PMC
December 2018
13 Reads

Risk factors associated with 31-day unplanned readmission in 50,912 discharged patients after stroke in China.

BMC Neurol 2018 Dec 26;18(1):218. Epub 2018 Dec 26.

School of Computer Science, Northwestern Polytechnical University Xi'an, Shangxi Province, 710129, China.

Background: Unplanned readmission within 31 days of discharge after stroke is a useful indicator for monitoring quality of hospital care. We evaluated the risk factors associated with 31-day unplanned readmission of stroke patients in China.

Methods: We identified 50,912 patients from 375 hospitals in 29 provinces, municipalities or autonomous districts across China who experienced an unplanned readmission after stroke between 2015 and 2016, and extracted data from the inpatients' cover sheet data from the Medical Record Monitoring Database. Read More

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http://dx.doi.org/10.1186/s12883-018-1209-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306006PMC
December 2018
11 Reads

Acute-onset multiple acyl-CoA dehydrogenase deficiency mimicking Guillain-Barré syndrome: two cases report.

BMC Neurol 2018 Dec 26;18(1):219. Epub 2018 Dec 26.

Department of Neurology, Peking University People's Hospital, #11 Xizhimen South Avenue, Xicheng District, Beijing, 100044, China.

Background: Multiple acyl-CoA dehydrogenase deficiency (MADD) showed great clinical heterogeneity and poses a challenge to diagnosis. Guillain-Barré syndrome (GBS) is an acute-onset autoimmune-mediated peripheral neuropathy. However, no patients of acute-onset MADD mimicking the GBS phenotype are reported previously. Read More

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http://dx.doi.org/10.1186/s12883-018-1221-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306005PMC
December 2018
8 Reads
2.040 Impact Factor

The cubital tunnel syndrome caused by intraneural ganglion cyst of the ulnar nerve at the elbow: a case report.

BMC Neurol 2018 Dec 22;18(1):217. Epub 2018 Dec 22.

Department of Hand Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province, 310003, People's Republic of China.

Background: Cubital tunnel syndrome is common nerve compression syndrome among peripheral nerve compression diseases. However, the syndrome caused by intraneural ganglion cysts has been rarely reported. Medical approaches, like ultrasound-guided aspiration and open surgical treatment remain to be discussed. Read More

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http://dx.doi.org/10.1186/s12883-018-1229-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303969PMC
December 2018
9 Reads

Rebound of relapses after discontinuation of rituximab in a patient with MOG-IgG1 positive highly relapsing optic neuritis: a case report.

BMC Neurol 2018 Dec 21;18(1):216. Epub 2018 Dec 21.

Department of Neurology, Seoul National University Hospital, 101, Daehak-Ro Jongno-Gu, Seoul, 03080, Republic of Korea.

Background: Myelin oligodendrocyte glycoprotein immunoglobulin G1 (MOG-IgG1)-associated disease is suggested as a separate disease entity distinct from multiple sclerosis and neuromyelitis optica spectrum disorder. Nonetheless, the optimal treatment regimen for preventing relapses in MOG-IgG1-associated disease remains unclear.

Case Presentation: We describe the case of a 45-year-old man with MOG-IgG1-positive highly relapsing optic neuritis who had experienced 5 attacks over 21 months and had monocular blindness despite prednisolone and azathioprine therapy. Read More

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http://dx.doi.org/10.1186/s12883-018-1222-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302456PMC
December 2018
1 Read

Predictors of thrombolysis in the telestroke and non telestroke settings for hypertensive acute ischemic stroke patients.

BMC Neurol 2018 Dec 21;18(1):215. Epub 2018 Dec 21.

University of South Carolina, School of Medicine-Greenville, Greenville, SC, 29605, USA.

Background: In acute ischemic stroke patients, telestroke technology provides sustainable approaches to improve the use of thrombolysis therapy. How this is achieved as it relates to inclusion or exclusion of clinical risk factors for thrombolysis is not fully understood. We investigated this in a population of hypertensive stroke patients. Read More

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http://dx.doi.org/10.1186/s12883-018-1204-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302528PMC
December 2018
8 Reads