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    1950 results match your criteria BMC Neurology[Journal]

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    Right-to-left shunt and subclinical ischemic brain lesions in Chinese migraineurs: a multicentre MRI study.
    BMC Neurol 2018 Feb 14;18(1):18. Epub 2018 Feb 14.
    Neuroscience Centre, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
    Background: Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with the increased prevalence of subclinical ischemic brain lesions in migraineurs.

    Methods: We enrolled 334 migraineurs from a multicentre study from June 2015 to August 2016. Read More

    Effect of tendon vibration during wide-pulse neuromuscular electrical stimulation (NMES) on muscle force production in people with spinal cord injury (SCI).
    BMC Neurol 2018 Feb 13;18(1):17. Epub 2018 Feb 13.
    Centre for Sports and Exercise Science, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia.
    Background: Neuromuscular electrical stimulation (NMES) is commonly used in skeletal muscles in people with spinal cord injury (SCI) with the aim of increasing muscle recruitment and thus muscle force production. NMES has been conventionally used in clinical practice as functional electrical stimulation (FES), using low levels of evoked force that cannot optimally stimulate muscular strength and mass improvements, and thus trigger musculoskeletal changes in paralysed muscles. The use of high intensity intermittent NMES training using wide-pulse width and moderate-intensity as a strength training tool could be a promising method to increase muscle force production in people with SCI. Read More

    Clinical benefit of improved Prehospital stroke scales to detect stroke patients with large vessel occlusions: results from a conditional probabilistic model.
    BMC Neurol 2018 Feb 10;18(1):16. Epub 2018 Feb 10.
    Universität Hamburg, Medizinische Fakultät, Hamburg, Germany.
    Background: Clinical scales to detect large vessel occlusion (LVO) may help to determine the optimal transport destination for patients with suspected acute ischemic stroke (AIS). The clinical benefit associated with improved diagnostic accuracy of these scales has not been quantified.

    Methods: We used a previously reported conditional model to estimate the probability of good outcome (modified Rankin scale sore ≤2) for patients with AIS and unknown vessel status occurring in regions with greater proximity to a primary than to a comprehensive stroke center. Read More

    Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999-2015.
    BMC Neurol 2018 Feb 7;18(1):15. Epub 2018 Feb 7.
    MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Tehran is the capital of Iran with an increasing multiple sclerosis (MS) prevalence. A retrospective population-based study was conducted to evaluate the trends of MS prevalence in Tehran.

    Methods: A population-based survey was conducted for the period 1999 to 2015, based on Iranian MS Society (IMSS) registry system of Tehran, the capital city of Iran. Read More

    The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis.
    BMC Neurol 2018 Jan 31;18(1):14. Epub 2018 Jan 31.
    Department of Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center - University of Freiburg, Hugstetter Strasse 55, D-79106, Freiburg, Germany.
    Background: Some rheumatologic disorders may initially manifest with central nervous system (CNS) affection, mimicking the clinical, magnetic resonance imaging, and cerebrospinal fluid findings of multiple sclerosis (MS). The MRZ reaction (MRZR), composed of the three respective antibody indices (AIs) against measles, rubella, and varicella zoster virus, has been found positive frequently in MS patients. However, it is unclear whether the MRZR is helpful to distinguish rheumatologic disorders with CNS involvement (RDwCNS) from MS. Read More

    Improving physical activity after stroke via treadmill training and self management (IMPACT): a protocol for a randomised controlled trial.
    BMC Neurol 2018 Jan 30;18(1):13. Epub 2018 Jan 30.
    Discipline of Physiotherapy, Faculty of Health Sciences, The University of Sydney, Sydney, NSW, Australia.
    Background: The level of physical activity undertaken by stroke survivors living in the community is generally low. The main objectives of the IMPACT trial are to determine, in individuals undergoing rehabilitation after stroke, if 8 weeks of high-intensity treadmill training embedded in self-management education (i) results in more physical activity than usual physiotherapy gait training and (ii) is more effective at increasing walking ability, cardiorespiratory fitness, self-efficacy, perception of physical activity, participation, and health-related quality of life as well as decreasing cardiovascular risk, and depression, at 8 and 26 weeks.

    Methods: A prospective, two-arm, parallel-group, randomised trial with concealed allocation, blinded measurement and intention-to-treat analysis, will be conducted. Read More

    Association between socioeconomic status and post-stroke functional outcome in deprived rural southern China: a population-based study.
    BMC Neurol 2018 Jan 25;18(1):12. Epub 2018 Jan 25.
    Department of Neurology and Stroke Center, the First Affiliated Hospital of Sun Yat-Sen University, No.58 Zhongshan Road 2, Guangzhou, 510080, China.
    Background: Data on the association between socioeconomic status and post-stroke functional outcome in developing countries is lacking. We aimed to evaluate the association in stroke survivors in deprived rural Southern China.

    Methods: We conducted door-to-door interviews and collected data using a structured questionnaire in stroke survivors from five fourth-class rural areas of Guangdong Province through a non-government initiated registry from August 2014 to March 2015. Read More

    SCL20A2 mutation presenting with acute ischemic stroke: a case report.
    BMC Neurol 2018 Jan 19;18(1):11. Epub 2018 Jan 19.
    Department of Neurology, Qianfoshan Hospital, Shandong University, Jinan, 250014, China.
    Background: Primary familial brain calcification (PFBC) is a rare disorder characterized by distinctive bilateral brain calcification and variable clinical presentations. However, cerebrovascular attack was rarely reported in PFBC patients. We here reported a SLC20A2 mutation patient presenting with acute ischemic stroke. Read More

    Intracisternal tuberculoma: a refractory type of tuberculoma indicating surgical intervention.
    BMC Neurol 2018 Jan 18;18(1):10. Epub 2018 Jan 18.
    Spinal Surgery Department, Guangzhou First People's Hospital, Guangzhou Medical University, 1# Panfu Road, Guangzhou, Guangdong, 510180, China.
    Background: Central nervous system (CNS) tuberculoma is a rare disease with severe neurological deficits. This retrospective research is to review the data of patients diagnosed as CNS tuberculoma. Surgeries were performed in all patients. Read More

    Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study.
    BMC Neurol 2018 Jan 17;18(1). Epub 2018 Jan 17.
    Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
    Background: Transcranial ultrasound is a useful tool for providing the evidences for the early diagnosis and differential diagnosis of Parkinson disease (PD). However, the relationship between hyper echogenicity in substantia nigra (SN) and clinical symptoms of PD patients remains unknown, and the role of dysfunction of iron metabolism on the pathogenesis of SN hyper echogenicity is unclear.

    Methods: PD patients was detected by transcranial sonography and divided into with no hyper echogenicity (PDSN-) group and with hyper echogenicity (PDSN+) group. Read More

    Reperfusion therapy in acute ischemic stroke: dawn of a new era?
    BMC Neurol 2018 Jan 16;18(1). Epub 2018 Jan 16.
    Western Sydney University (WSU), School of Medicine, South West Sydney Clinical School, Sydney, NSW, 2170, Australia.
    Following the success of recent endovascular trials, endovascular therapy has emerged as an exciting addition to the arsenal of clinical management of patients with acute ischemic stroke (AIS). In this paper, we present an extensive overview of intravenous and endovascular reperfusion strategies, recent advances in AIS neurointervention, limitations of various treatment paradigms, and provide insights on imaging-guided reperfusion therapies. A roadmap for imaging guided reperfusion treatment workflow in AIS is also proposed. Read More

    Rationale and design of the CAROLINA® - cognition substudy: a randomised controlled trial on cognitive outcomes of linagliptin versus glimepiride in patients with type 2 diabetes mellitus.
    BMC Neurol 2018 Jan 15;18(1). Epub 2018 Jan 15.
    Clinical development, Therapeutic Area Metabolism, Boehringer Ingelheim, Asker, Norway.
    Background: Type 2 diabetes mellitus is associated with cognitive dysfunction and an increased risk of dementia. Linagliptin is a glucose-lowering agent of the dipeptidyl peptidase-IV (DPP-IV) inhibitor class that is of particular interest for the prevention of accelerated cognitive decline, because it may potentially benefit the brain through pleiotropic effects, beyond glucose lowering. This paper presents the design of a study that aims to establish if linagliptin is superior to the sulfonylurea glimepiride in the prevention of accelerated cognitive decline in patients with type 2 diabetes mellitus. Read More

    Chinese Cervicocephalic artery dissection study (CCADS): rationale and protocol for a multicenter prospective cohort study.
    BMC Neurol 2018 Jan 11;18(1). Epub 2018 Jan 11.
    Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
    Background: Cervicocephalic artery dissection (CAD) is an important etiology of stroke in the youth. Findings from recent studies suggest it a "group of disease entities" with different underlying etiologies, presentations and prognosis, necessitating an integral study including various types of CAD to get a better understanding of this disease. In addition, Chinese patients with CAD are likely to carry different features from their western counterparts, which remains uncertain yet. Read More

    Revealing Alzheimer's disease genes spectrum in the whole-genome by machine learning.
    BMC Neurol 2018 Jan 10;18(1). Epub 2018 Jan 10.
    BGI-Shenzhen, Shenzhen, 518083, China.
    Background: Alzheimer's disease (AD) is an important, progressive neurodegenerative disease, with a complex genetic architecture. A key goal of biomedical research is to seek out disease risk genes, and to elucidate the function of these risk genes in the development of disease. For this purpose, expanding the AD-associated gene set is necessary. Read More

    Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease.
    BMC Neurol 2018 Jan 9;18(1). Epub 2018 Jan 9.
    Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
    Backgrounds: Long non-coding RNA (LncRNA) have been reported to be involved in the pathogenesis of neurodegenerative diseases, but whether it can serve as a biomarker for Alzheimer disease (AD) is not yet known.

    Methods: The present study selected four specific LncRNA (17A, 51A, BACE1 and BC200) as possible AD biomarker. RT-qPCR was performed to validate the LncRNA. Read More

    Daily repetitive sensory stimulation of the paretic hand for the treatment of sensorimotor deficits in patients with subacute stroke: RESET, a randomized, sham-controlled trial.
    BMC Neurol 2018 Jan 9;18(1). Epub 2018 Jan 9.
    Institute for Neuroinformatik, Neural Plasticity Lab, Ruhr-University of Bochum, Bochum, Germany.
    Background: Repetitive sensory stimulation (RSS) adapts the timing of stimulation protocols used in cellular studies to induce synaptic plasticity. In healthy subjects, RSS leads to widespread sensorimotor cortical reorganization paralleled by improved sensorimotor behavior. Here, we investigated whether RSS reduces sensorimotor upper limb impairment in patients with subacute stroke more effectively than conventional therapy. Read More

    Frequency of SCA8, SCA10, SCA12, SCA36, FXTAS and C9orf72 repeat expansions in SCA patients negative for the most common SCA subtypes.
    BMC Neurol 2018 Jan 9;18(1). Epub 2018 Jan 9.
    Department of Human Genetics, Ruhr-University, Gebäude MA5/39, Universitätsstraße 150, 44801, Bochum, Germany.
    Background: Spinocerebellar ataxia (SCA) subtypes are often caused by expansions in non-coding regions of genes like SCA8, SCA10, SCA12 and SCA36. Other ataxias are known to be associated with repeat expansions such as fragile X-associated tremor ataxia syndrome (FXTAS) or expansions in the C9orf72 gene. When no mutation has been identified in the aforementioned genes next-generation sequencing (NGS)-based diagnostics may also be applied. Read More

    MR imaging features of benign retroperitoneal paragangliomas and schwannomas.
    BMC Neurol 2018 Jan 4;18(1). Epub 2018 Jan 4.
    Department of Radiology, Chinese PLA General Hospital, Fuxing Road 28, Box, Beijing, 100853, China.
    Background: To determine whether MRI feature analysis can differentiate benign retroperitoneal extra-adrenal paragangliomas and schwannomas.

    Methods: The MRI features of 50 patients with confirmed benign retroperitoneal extra-adrenal paragangliomas and schwannomas were retrospectively reviewed by two radiologists blinded to the histopathologic diagnosis. These features were compared between two types of tumours by use of the Mann-Whitney test and binary logistic regression. Read More

    The relationship between lower limb muscle volume and body mass in ambulant individuals with bilateral cerebral palsy.
    BMC Neurol 2017 Dec 29;17(1):223. Epub 2017 Dec 29.
    One Small Step Gait Laboratory, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London, SE1 9RT, UK.
    Background: Individuals with cerebral palsy have smaller muscle volumes normalised to body mass than their typically developing peers. The aim of this study is to investigate the relationship between lower limb muscle volume and body mass in young people with bilateral cerebral palsy and their typically developing peers.

    Methods: Twenty-five participants with bilateral cerebral palsy (aged 14. Read More

    Nitrous oxide induced subacute combined degeneration with longitudinally extensive myelopathy with inverted V-sign on spinal MRI: a case report and literature review.
    BMC Neurol 2017 Dec 28;17(1):222. Epub 2017 Dec 28.
    Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
    Background: Nitrous oxide (N2O), a long-standing anesthetic, is also neurotoxic by interfering with the bioavailability of vitamin B12 if abused. A few case studies have reported the neurological and psychiatric complications of N2O.

    Case Presentation: Here, we reported a patient of N2O induced subacute combined degeneration (SCD) with longitudinally extensive myelopathy with inverted V-sign exhibiting progressive limb paresthesia and unsteady gait. Read More

    The analysis of relationship between selected sociodemografic factors and disorders of speech organs in Parkinson`s patients.
    BMC Neurol 2017 Dec 21;17(1):221. Epub 2017 Dec 21.
    Chair and Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252, Szczecin, Poland.
    Background: Evaluation of speech disorders in PD taking into account sociodemographic conditions is not frequent. This paper aims to establish correlations between articulation disorders in PD patients and factors such as the patients' sex, age, education and residence.

    Methods: The study included 92 patients with idiopathic PD diagnosed by means of multiple neurological examinations, biochemical tests, MRI and CT scanning carried out in accordance with the United Kingdom Parkinson's Disease Society Brain Bank (UKPDSBB) criteria. Read More

    Cortical vein thrombosis in adult patients of cerebral venous sinus thrombosis correlates with poor outcome and brain lesions: a retrospective study.
    BMC Neurol 2017 Dec 15;17(1):219. Epub 2017 Dec 15.
    Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan Road II, Guangzhou, 510080, People's Republic of China.
    Background: Cortical vein thrombosis (CVT) receives little attention in adult patients with cerebral venous sinus thrombosis (CVST). This study aimed to investigate the clinical and radiological features of adult CVST patients with concomitant CVT.

    Methods: From May 2009 to May 2016, we recruited 44 adult CVST patients (diagnosed within 1 month of onset; 33. Read More

    Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat.
    BMC Neurol 2017 Dec 16;17(1):220. Epub 2017 Dec 16.
    Molecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Recent studies shows that hyperbaric oxygen (HBO) therapy exerts some protective effects against neural injuries. The purpose of this study was to determine the neuroprotective effects of HBO following sciatic nerve transection (SNT).

    Methods: Rats were randomly divided into five groups (n = 14 per group): Sham-operated (SH) group, SH + HBO group, SNT group, and SNT + pre- and SNT + post-HBO groups (100% oxygen at 2. Read More

    Predictors of post-stroke body temperature elevation.
    BMC Neurol 2017 Dec 13;17(1):218. Epub 2017 Dec 13.
    Department of Neurology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Background: Growing evidence indicates that elevated body temperature after stroke is associated with unfavorable outcome. The aim of the current study was to investigate which factors predict temperature elevation within 48 h of stroke onset. Specifically, we hypothesized that temperature elevation would be associated with stroke symptom severity and that hemorrhagic stroke would cause a more pronounced temperature increase compared to ischemic stroke. Read More

    Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report.
    BMC Neurol 2017 Dec 13;17(1):217. Epub 2017 Dec 13.
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
    Background: Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome, is the most common phenotype of mitochondrial disease. It often develops in childhood or adolescence, usually before the age of 40, in a maternally-inherited manner. Mutations in mitochondrial DNA (mtDNA) are frequently responsible for MELAS. Read More

    Etiology of isolated pontine infarctions: a study based on high-resolution MRI and brain small vessel disease scores.
    BMC Neurol 2017 Dec 12;17(1):216. Epub 2017 Dec 12.
    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    Background: In this retrospective study, we investigated the main pathogenesis of the two types of isolated pontine infarction: paramedian pontine infarcts (PPIs) and small deep pontine infarcts (SDPIs).

    Methods: Acute ischemic stroke patients, comprising 117 PPI patients and 40 SDPI patients, were enrolled. High-resolution magnetic resonance imaging (HR-MRI) and routine MRI sequences were performed for each patient, and clinical data were collected. Read More

    CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population.
    BMC Neurol 2017 Dec 11;17(1):214. Epub 2017 Dec 11.
    Department of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
    Background: CDKN2BAS gene polymorphisms has been shown to correlation with intracranial aneurysm(IA) in the study of foreign people. The study, the author selected the Chinese people as the research object to explore whether CDKN2BAS gene polymorphisms associated with Chinese patients with IA.

    Methods: We selected 200 patients(52. Read More

    Secondary pallidonigral degeneration mimicking recurrent acute stroke in clinical presentation and magnetic resonance imaging: a case report.
    BMC Neurol 2017 Dec 11;17(1):215. Epub 2017 Dec 11.
    Department of Medical Imaging, Taipei Medical University Hospital, 252 Wu Hsing Street, Taipei, 110, Taiwan.
    Background: Secondary pallidonigral transneuronal degeneration after a remote primary cerebral infarct can mimic recurrent stroke at clinical presentation. We describe a patient with secondary pallidonigral degeneration following a previous putaminal infarct, which was diagnosed through diffusion-weighted (DWI) and T2-weighted imaging (T2WI).

    Case Presentation: A 64-year-old man complained of an acute relapse of right-lower-limb weakness following a cerebral infarction 2 months before presentation. Read More

    Anterior sacral meningocele infected with Fusobacterium in a patient with recently diagnosed colorectal carcinoma - a case report.
    BMC Neurol 2017 Dec 8;17(1):212. Epub 2017 Dec 8.
    Department of Neurology, RWTH University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.
    Background: Anterior sacral meningoceles are rare, and usually occur with other malformations of the posterior lower spine. While these are more frequently reported in pediatric cohorts, we report a case in an elderly woman.

    Case Presentation: We report on a 71 year-old woman with a recently diagnosed colorectal adenocarcinoma who presented with a severe bacterial meningitis. Read More

    Inventory of real world data sources in Parkinson's disease.
    BMC Neurol 2017 Dec 8;17(1):213. Epub 2017 Dec 8.
    Lundbeck SAS, 37-45 Quai du Président Roosevelt, CEDEX 92445, Issy-les-Moulineaux, France.
    Background: Real world data have an important role to play in the evaluation of epidemiology and burden of disease; and in assisting health-care decision-makers, especially related to coverage and payment decisions. However, there is currently no overview of the existing longitudinal real world data sources in Parkinson's disease (PD) in the USA. Such an assessment can be very helpful, to support a future effort to harmonize real world data collection and use the available resources in an optimal way. Read More

    Factors necessary for independent walking in patients with thalamic hemorrhage.
    BMC Neurol 2017 Dec 8;17(1):211. Epub 2017 Dec 8.
    Department of Rehabilitation Medicine II, School of Medicine, Fujita Health University, Tsu, Japan.
    Background: Thalamic hemorrhages cause motor paralysis, sensory impairment, and cognitive dysfunctions, all of which may significantly affect walking independence. We examined the factors related to independent walking in patients with thalamic hemorrhage who were admitted to a rehabilitation hospital.

    Methods: We evaluated 128 patients with thalamic hemorrhage (75 men and 53 women; age range, 40-93 years) who were admitted to our rehabilitation hospital. Read More

    Pharmacological targeting of secondary brain damage following ischemic or hemorrhagic stroke, traumatic brain injury, and bacterial meningitis - a systematic review and meta-analysis.
    BMC Neurol 2017 Dec 7;17(1):209. Epub 2017 Dec 7.
    Department of Neurosurgery, Medical Faculty, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.
    Background: The effectiveness of pharmacological strategies exclusively targeting secondary brain damage (SBD) following ischemic stroke, aneurysmal subarachnoid hemorrhage, aSAH, intracerebral hemorrhage (ICH), traumatic brain injury (TBI) and bacterial meningitis is unclear. This meta-analysis studied the effect of SBD targeted treatment on clinical outcome across the pathological entities.

    Methods: Randomized, controlled, double-blinded trials on aforementioned entities with 'death' as endpoint were identified. Read More

    Widespread enlarged perivascular spaces associated with dementia and focal brain dysfunction: case report.
    BMC Neurol 2017 Dec 7;17(1):210. Epub 2017 Dec 7.
    Department of Neurology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan.
    Background: Enlarged perivascular spaces (PVS) are common magnetic resonance imaging (MRI) findings, whereas widespread enlarged PVS are extremely rare. Although most patients with widespread enlarged PVS remain asymptomatic, some develop neurological dysfunctions; however, it remains unclear whether these are the consequence of widespread enlarged PVS.

    Case Presentation: A 64-year-old female patient developed consciousness disturbance, cognitive dysfunctions, fluent aphasia, agraphia, acalculia, and left-right disorientation after suffering from bronchopneumonia. Read More

    The Turkish validation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery.
    BMC Neurol 2017 Dec 6;17(1):208. Epub 2017 Dec 6.
    Department of Neurology, Usak State Hospital, Usak, Turkey.
    Background: Cognitive impairment may be seen in as many as 43-70% of patients with multiple sclerosis (MS) and may be observed in all MS subtypes. The Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS) battery may be used to evaluate cognition status. The purpose of the current study is to validate the BICAMS battery in Turkish. Read More

    Normothermia after decompressive surgery for space-occupying middle cerebral artery infarction: a protocol-based approach.
    BMC Neurol 2017 Dec 4;17(1):205. Epub 2017 Dec 4.
    Department of Neurology, University Hospital, Technische Universität Dresden, Dresden, Germany.
    Background: Moderate hypothermia after decompressive surgery might not be beneficial for stroke patients. However, normothermia may prove to be an effective method of enhancing neurological outcomes. The study aims were to evaluate the application of a pre-specified normothermia protocol in stroke patients after decompressive surgery and its impact on temperature load, and to describe the functional outcome of patients at 12 months after treatment. Read More

    Selection bias in clinical stroke trials depending on ability to consent.
    BMC Neurol 2017 Dec 4;17(1):206. Epub 2017 Dec 4.
    Center for Stroke Research Berlin, Charité University Hospital Berlin, Charitéplatz 1, 10115, Berlin, Germany.
    Background: Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not being able to give informed consent. In some nations, ethics committees will not approve of inclusion in a clinical study via consent of a legal representative. The ethical dilemma of including or excluding those patients has not been properly addressed, as there is little data on the effect of stroke characteristics on the ability to give informed consent. Read More

    Atrial fibrillation is not uncommon among patients with ischemic stroke and transient ischemic stroke in China.
    BMC Neurol 2017 Dec 4;17(1):207. Epub 2017 Dec 4.
    Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China.
    Background: Atrial fibrillation (AF) is reported to be a less frequent cause of ischemic stroke in China than in Europe and North America, but it is not clear whether this is due to underestimation. Our aim was to define the true frequency of AF-associated stroke, to determine the yield of 6-day Holter ECG to detect AF in Chinese stroke patients, and to elucidate predictors of newly detected AF.

    Methods: Patients with acute ischemic stroke or transient ischemic attack (TIA) were enrolled in a prospective, multicenter cohort study of 6-day Holter monitoring within 7 days after stroke onset at 20 sites in China between 2013 and 2015. Read More

    Self-reported physical activity correlates in Swedish adults with multiple sclerosis: a cross-sectional study.
    BMC Neurol 2017 Dec 1;17(1):204. Epub 2017 Dec 1.
    Department of Neuroscience, Section for Physiotherapy, Box 593 Uppsala University, 751 24, Uppsala, Sweden.
    Background: The benefits of physical activity in persons with Multiple Sclerosis (MS) are considerable. Knowledge about factors that correlate to physical activity is helpful in order to develop successful strategies to increase physical activity in persons with MS. Previous studies have focused on correlates to physical activity in MS, however falls self-efficacy, social support and enjoyment of physical activity are not much studied, as well as if the correlates differ with regard to disease severity. Read More

    Prescription of secondary preventive drugs after ischemic stroke: results from the Malaysian National Stroke Registry.
    BMC Neurol 2017 Nov 23;17(1):203. Epub 2017 Nov 23.
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
    Background: Evaluation of secondary stroke prevention in low and middle-income countries remains limited. This study assessed the prescription of secondary preventive drugs among ischemic stroke patients upon hospital discharge in Malaysia and identified factors related to the prescribing decisions.

    Methods: From Malaysian National Stroke Registry, we included patients with non-fatal ischemic stroke. Read More

    The humanistic burden of Pompe disease: are there still unmet needs? A systematic review.
    BMC Neurol 2017 Nov 22;17(1):202. Epub 2017 Nov 22.
    Audentes Therapeutics, 600 California Street, Floor 17, San Francisco, CA, 94104, USA.
    Background: Humanistic burden considers the impact of an illness on a patient's health-related quality of life (HRQoL), activities of daily living (ADL), caregiver health, and caregiver QoL. Humanistic burden also considers treatment satisfaction and adherence to treatment regimens. Pompe disease is an autosomal recessive, progressive, multisystemic neuromuscular disease. Read More

    Cognitive rehabilitation and mindfulness in multiple sclerosis (REMIND-MS): a study protocol for a randomised controlled trial.
    BMC Neurol 2017 Nov 21;17(1):201. Epub 2017 Nov 21.
    Department of Neurology, Amsterdam Neuroscience, MS Center Amsterdam, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, the Netherlands.
    Background: Cognitive problems frequently occur in patients with multiple sclerosis (MS) and profoundly affect their quality of life. So far, the best cognitive treatment options for MS patients are a matter of debate. Therefore, this study aims to investigate the effectiveness of two promising non-pharmacological treatments: cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT). Read More

    The usefulness of chief complaints to predict severity, ventilator dependence, treatment option, and short-term outcome of patients with Guillain-Barré syndrome: a retrospective study.
    BMC Neurol 2017 Nov 21;17(1):200. Epub 2017 Nov 21.
    Neuroscience Centre, Department of Neurology, the First Hospital of Jilin University, Xinmin Street 71#, Changchun, 130021, China.
    Background: It remains an urgent need for early recognition of disease severity, treatment option and outcome of Guillain-Barré syndrome (GBS). The chief complaint may be quickly obtained in clinic and is one of the candidates for early predictors. However, studies on the chief complaint are still lacking in GBS. Read More

    Predictors of early-onset post-ischemic stroke depression: a cross-sectional study.
    BMC Neurol 2017 Nov 17;17(1):199. Epub 2017 Nov 17.
    Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
    Background: Post-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality of life. However, the pathogenesis of PSD is still not clear. This study aimed to investigate the demographic, clinical, and biochemical factors in patients with PSD. Read More

    EEG dynamical correlates of focal and diffuse causes of coma.
    BMC Neurol 2017 Nov 15;17(1):197. Epub 2017 Nov 15.
    Department of Electrical and Systems Engineering, Washington University in St. Louis, 1 Brookings Dr. Campus Box 1042, St. Louis, MO, 63130, USA.
    Background: Rapidly determining the causes of a depressed level of consciousness (DLOC) including coma is a common clinical challenge. Quantitative analysis of the electroencephalogram (EEG) has the potential to improve DLOC assessment by providing readily deployable, temporally detailed characterization of brain activity in such patients. While used commonly for seizure detection, EEG-based assessment of DLOC etiology is less well-established. Read More

    Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels.
    BMC Neurol 2017 Nov 15;17(1):198. Epub 2017 Nov 15.
    Department of Psychiatry, School of Medicine, Washington University in Saint Louis, Saint Louis, MO, USA.
    Background: The genetic architecture of Parkinson's Disease (PD) is complex and not completely understood. Multiple genetic studies to date have identified multiple causal genes and risk loci. Nevertheless, most of the expected genetic heritability remains unexplained. Read More

    Neuroprotective effect of neuroserpin in non-tPA-induced intracerebral hemorrhage mouse models.
    BMC Neurol 2017 Nov 7;17(1):196. Epub 2017 Nov 7.
    Department of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, People's Republic of China.
    Background: The neuroprotective effects of neuroserpin (NSP) have been well documented in both patients and animal models with cerebral ischemia; however, have never been investigated in hemorrhagic stroke. The aim of this study is to verify the neuroprotection of NSP in the non-tPA-induced intracerebral hemorrhage (ICH) mouse model.

    Methods: C57BL/6J male mice (n = 198) were involved in this study. Read More

    Application of the 2016 diagnostic approach for autoimmune encephalitis from Lancet Neurology to Chinese patients.
    BMC Neurol 2017 Nov 6;17(1):195. Epub 2017 Nov 6.
    Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.
    Background: A unified clinical approach to diagnose autoimmune encephalitis was published in Lancet Neurology in 2016. Purpose of our study is to examine the feasibility and reasonability of the 2016 "A clinical approach to diagnosis of autoimmune encephalitis" in China with a retrospective study.

    Methods: We retrospectively collected 95 cases of autoimmune encephalitis and non autoimmune encephalitis cases with detailed clinical data from Beijing Tongren Hospital and the China National Knowledge Infrastructure (CNKI). Read More

    Ultra high-field SWI of the substantia nigra at 7T: reliability and consistency of the swallow-tail sign.
    BMC Neurol 2017 Oct 26;17(1):194. Epub 2017 Oct 26.
    Department of Neuroradiology, University Hospital Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany.
    Background: The loss of the swallow-tail sign of the substantia nigra has been proposed for diagnosis of Parkinson's disease. Aim was to evaluate, if the sign occurs consistently in healthy subjects and if it can be reliably detected with high-resolution 7T susceptibility weighted imaging (SWI).

    Methods: Thirteen healthy adults received SWI at 7T. Read More

    Headache symptoms from migraine patients with and without aura through structure-validated self-reports.
    BMC Neurol 2017 Oct 12;17(1):193. Epub 2017 Oct 12.
    Department of Clinical Psychology and Psychiatry/School of Public Health, Zhejiang University College of Medicine, Hangzhou, China.
    Background: Headache symptoms self-reported by migraine patients are largely congruent with the clinician-used diagnostic criteria, but not always so. Patients' self-reports of headache symptoms might offer additional clues to characterize migraine with (MA) and without (MO) aura more precisely.

    Methods: Firstly, we invited 324 participants with a life-long headache attack to answer an item-matrix measuring symptoms of primary headaches, then we performed both exploratory and confirmatory factor analyses to their answers and refined a headache symptom questionnaire. Read More

    Effects of Homocysteine on white matter diffusion parameters in Alzheimer's disease.
    BMC Neurol 2017 Oct 6;17(1):192. Epub 2017 Oct 6.
    Department of Biomedical Engineering, I-Shou University, Kaohsiung, Taiwan.
    Background: The clinical features of Alzheimer's disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four diffusion tensor imaging parameters in the white matter of patients with early stage AD, examined their associations with homocysteine level, and tested the clinical significance of the diffusion tensor imaging parameters and homocysteine level in correlation analysis with cognitive test scores.

    Methods: We enrolled 132 patients with AD and analyzed white matter (WM) macrostructural changes using diffusion tensor neuroimaging parameters including fractional anisotropy (FA), mean diffusion (MD), axial diffusivity (axial-D) and radial diffusivity (RD). Read More

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