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    2017 results match your criteria BMC Neurology[Journal]

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    Wilson's disease combined with systemic lupus erythematosus: a case report and literature review.
    BMC Neurol 2018 Jun 15;18(1):85. Epub 2018 Jun 15.
    PublicationChinese Academy of Medical Science (CAMS) and Peking Union Medical College (PUMC), Beijing, 100730, China.
    Background: Wilson's disease (WD) is an inherited disorder in which defective biliary excretion of copper leads to its accumulation, particularly in the liver and brain. Systemic lupus erythematosus (SLE) is a multi-system disorder that can manifest in any system. Cases with concomitant WD and SLE, unrelated to treatment with penicillamine, have been rarely reported. Read More

    Relationship between the geometry patterns of vertebrobasilar artery and atherosclerosis.
    BMC Neurol 2018 Jun 12;18(1):83. Epub 2018 Jun 12.
    Department of Neurology and Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1, Dongcheng District, Beijing, 100730, China.
    Background: The plaques at the dorsal or lateral wall of basilar artery (BA) are associated with pontine infarcts. We sought to explore the correlations between vertebrobasilar artery geometry and BA plaque locations.

    Methods: We retrospectively analyzed the imaging and clinical data of 84 patients with BA atherosclerosis. Read More

    Correction to: Case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito.
    BMC Neurol 2018 Jun 12;18(1):84. Epub 2018 Jun 12.
    Hospital Carlos Andrade Marín, Av. 18 de Septiembre y Ayacucho, Quito, Ecuador.
    Following publication of the original article [1], Andrés Damián Ortega Heredia requested that his name be corrected from. Read More

    Computer-assisted rehabilitation of attention in pediatric multiple sclerosis and ADHD patients: a pilot trial.
    BMC Neurol 2018 Jun 8;18(1):82. Epub 2018 Jun 8.
    MS Centre, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", Bari, Piazza G. Cesare, 11, 70121, Bari, Italy.
    Background: The treatment of cognitive deficits is challenging in pediatric onset multiple sclerosis (POMS) and in patients with attention deficit hyperactivity disorder (ADHD). We performed a pilot double-blind RCT to evaluate the efficacy of a home-based computerized-program for retraining attention in two cohorts of POMS and ADHD patients.

    Methods: POMS and ADHD patients failing in at least 2/4 attention tests on a neuropsychological battery were randomized to specific or nonspecific computerized training (ST, nST), performed in one-hour sessions, twice/week for 3 months. Read More

    Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy.
    BMC Neurol 2018 Jun 7;18(1):81. Epub 2018 Jun 7.
    Department of Physiology, Faculty of Medicine, Bilim University, Istanbul, Turkey.
    Background: Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), which are variably expressed in the brain, has been demonstrated to reduce seizure activity in murine models of epilepsy. Read More

    A case report: a heterozygous deletion (2791_2805 del) in exon 18 of the filamin C gene causing filamin C-related myofibrillar myopathies in a Chinese family.
    BMC Neurol 2018 Jun 4;18(1):79. Epub 2018 Jun 4.
    Department of Neurology and Neuroscience Center First Affiliated Hospital of Jilin University, Changchun, 130021, Jilin, People's Republic of China.
    Background: Filamin C-related myofibrillar myopathies (MFM) are progressive skeletal myopathies with an autosomal dominant inheritance pattern. The conditions are caused by mutations of the filamin C gene (FLNC) located in the chromosome 7q32-q35 region. Genetic variations in the FLNC gene result in various clinical phenotypes. Read More

    Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway.
    BMC Neurol 2018 Jun 4;18(1):80. Epub 2018 Jun 4.
    Department of Medical Instruments, Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang, 157009, People's Republic of China.
    Backgrounds: Glioma is the most fatal primary brain glioma in central nervous system mainly attributed to its high invasion. Prucalopride, a Serotonin-4 (5-HT4) receptor agonist, has been reported to regulate neurodevelopment. This study aimed to investigate the influence of the Prucalopride on glioma cells and unveil underlying mechanism. Read More

    Hemoglobin concentration does not impact 3-month outcome following acute ischemic stroke.
    BMC Neurol 2018 Jun 2;18(1):78. Epub 2018 Jun 2.
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
    Background: There is uncertainty regarding the effect of anemia and red blood cell transfusion on functional outcome following acute ischemic stroke. We studied the relationship of hemoglobin parameters and red cell transfusion with post stroke functional outcome after adjustment for neurological severity and medical comorbidities.

    Methods: Retrospective cohort study of 536 patients discharged with a diagnosis of ischemic stroke from a tertiary care hospital between January 2012 and April 2015. Read More

    Horizontal gaze palsy with progressive scoliosis: a case report with magnetic resonance tractography and electrophysiological study.
    BMC Neurol 2018 May 29;18(1):75. Epub 2018 May 29.
    Department of Neurology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
    Background: Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare autosomal recessive congenital anomaly characterized by horizontal gaze limitation and progressive scoliosis. We investigated the underlying pathogenesis by incorporating diffusion tensor imaging and an electrophysiological study.

    Case Presentation: A 55-year-old female patient presented to our clinic due to a chronic history of eye movement limitation since childhood. Read More

    Unusual presentation of a skull base mass lesion in sarcoidosis mimicking malignant neoplasm: a case report.
    BMC Neurol 2018 May 29;18(1):77. Epub 2018 May 29.
    Department of Neurological Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-Kamimachi, Itabashi-ku, Tokyo, 173-8610, Japan.
    Background: Sarcoidosis is a multi-organ disease of unknown etiology characterised by the presence of epithelioid granulomas, without caseous necrosis. Systemic sarcoidosis is rare among children, while neurosarcoidosis in children is even rarer whether it is systemic or not.

    Case Presentation: We described the case of a 12-year-old boy who presented with monocular vision loss accompanied by unusual MRI features of an extensive meningeal infiltrating mass lesion. Read More

    Dyke-Davidoff-Masson syndrome: a case report.
    BMC Neurol 2018 May 29;18(1):76. Epub 2018 May 29.
    Department of Imaging, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
    Background: Dyke-Davidoff-Masson syndrome is a rare condition of unknown frequency resulting from brain injury due to a multitude of causes; especially in early life. Characteristics include cerebral hemiatrophy/hypoplasia, contralateral hemiparesis, seizures, and compensatory osseous hypertrophy.

    Case Presentation: We present a case of a 13-year-old girl who initially presented with headaches, followed by episodic complex-partial seizures; which was controlled via medication. Read More

    A case report of multiple cervical artery dissection after peripheral type facial palsy and use of steroids.
    BMC Neurol 2018 May 28;18(1):74. Epub 2018 May 28.
    Department of Neurology, Kyung Hee University Hospital College of Medicine, Kyung Hee University, 23, Kyung Hee Dae-ro, Dongdaemun-gu, Seoul, 190, Republic of Korea.
    Background: Cervical artery dissection is one of the most important causes of ischemic stroke in young age patients. However, multiple cervical artery dissection simultaneously involving the anterior and posterior circulation is uncommon. Here, we would like to report a case of a patient with bilateral vertebral artery (VA) and internal carotid artery dissection (ICA) after a use of systemic steroid due to peripheral facial palsy. Read More

    Reduced gray matter volume and respiratory dysfunction in Parkinson's disease: a voxel-based morphometry study.
    BMC Neurol 2018 May 26;18(1):73. Epub 2018 May 26.
    Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung, 83305, Taiwan.
    Background: The respiratory dysfunction of patients with Parkinson's disease (PD) has drawn increasing attention. This study evaluated the relationship between gray matter volume (GMV), as determined by voxel-based morphometry (VBM), and respiratory dysfunction in patients with PD and correlated it with systemic inflammatory markers.

    Methods: Whole-brain VBM analysis was performed on 3-dimensional T1-weighted images in 25 PD patients with abnormal pulmonary function (13 men, 12 women; mean age: 62. Read More

    Hopkins syndrome following the first episode of bronchial asthma associated with enterovirus D68: a case report.
    BMC Neurol 2018 May 23;18(1):71. Epub 2018 May 23.
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
    Background: Hopkins syndrome (HS) is a rare disorder presenting with acute flaccid paralysis of the limbs following an asthma attack. Neurologists encounter a diagnostic challenge if patients without a history of bronchial asthma develop neurologic features mimicking HS following acute respiratory distress. We report a case of HS occurring after a first episode of bronchial asthma associated with enterovirus D68 infection. Read More

    Anti-ganglioside complex antibody profiles in a recurrent complicated case of GQ1b-seronegative miller fisher syndrome and Bickerstaff brainstem encephalitis: a case report.
    BMC Neurol 2018 May 23;18(1):72. Epub 2018 May 23.
    Department of Neurology, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, Japan.
    Background: Guillain-Barré syndrome (GBS), Miller Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis (BBE) are a group of autoimmune neurological disorders (GBS spectrum disorder) that rarely recur. Recently, anti-ganglioside complex antibodies (GSC-Abs) were identified in patients with GBS spectrum disorder. However, there has been no case report describing GSC-Abs profiles in a recurrent case showing different phenotypes. Read More

    Primary headaches in children and adolescents - experiences at a single headache center in Korea.
    BMC Neurol 2018 May 21;18(1):70. Epub 2018 May 21.
    Department of Pediatrics, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
    Background: Headache is a common complaint in children and adolescents. Recently, an increased prevalence of headache in children and adolescents has been reported.

    Methods: We retrospectively reviewed the medical records of children and adolescents attending the Headache Clinic of Daejeon St. Read More

    Parkinson's Disease Diagnostic Observations (PADDO): study rationale and design of a prospective cohort study for early differentiation of parkinsonism.
    BMC Neurol 2018 May 16;18(1):69. Epub 2018 May 16.
    Radboud university medical center, Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, P.O.Box 9101, 6500 HB, Nijmegen (935), The Netherlands.
    Background: Differentiation of Parkinson's disease (PD) from the various types of atypical parkinsonism (AP) such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), dementia with Lewy bodies (DLB), corticobasal syndrome (CBS) and vascular parkinsonism (VP), can be challenging, especially early in the disease course when symptoms overlap. A major unmet need in the diagnostic workup of these disorders is a diagnostic tool that differentiates the various disorders, preferably in the earliest disease stages when the clinical presentation is similar. Many diagnostic tests have been evaluated, but their added value was studied mostly in retrospective case-control studies that included patients with a straightforward clinical diagnosis. Read More

    Predictive value of early magnetic resonance imaging measures is differentially affected by the dose of interferon beta-1a given subcutaneously three times a week: an exploratory analysis of the PRISMS study.
    BMC Neurol 2018 May 11;18(1):68. Epub 2018 May 11.
    Mount Sinai Hospital, 5 East 98th Street, 1st Floor, New York, NY, 10029, USA.
    Background: On-treatment magnetic resonance imaging lesions may predict long-term clinical outcomes in patients receiving interferon β-1a. This study aimed to assess the effect of active T2 and T1 gadolinium-enhancing (Gd+) lesions on relapses and 3-month confirmed Expanded Disability Status Scale (EDSS) progression in the PRISMS clinical trial.

    Methods: Exploratory analyses assessed whether active T2 and T1 Gd + lesions at Month 6, or active T2 lesions at Month 12, predicted clinical outcomes over 4 years in PRISMS. Read More

    A cross-sectional and longitudinal study evaluating brain volumes, RNFL, and cognitive functions in MS patients and healthy controls.
    BMC Neurol 2018 May 11;18(1):67. Epub 2018 May 11.
    Multiple Sclerosis Center Binaghi Hospital, Department of Medical Sciences and Public Health, University of Cagliari, via Is Guadazzonis 2, 09126, Cagliari, Italy.
    Background: The principal biomarker of neurodegeneration in multiple sclerosis (MS) is believed to be brain volume, which is associated with cognitive functions and retinal nerve fibre layer (RNFL). A cross-sectional and longitudinal assessment of the relationship between RNFL, cognitive functions and brain volume.

    Methods: At baseline, relapsing patients and healthy controls underwent 1. Read More

    Differentiation of neuropsychological features between posterior cortical atrophy and early onset Alzheimer's disease.
    BMC Neurol 2018 May 10;18(1):65. Epub 2018 May 10.
    Innovation Center for Neurological Disorders, Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
    Background: Posterior cortical atrophy (PCA) is a group of clinical syndromes characterized by visuospatial and visuoperceptual impairment, with memory relatively preserved. Although PCA is pathologically almost identical to Alzheimer's disease (AD), they have different cognitive features. Those differences have only rarely been reported in any Chinese population. Read More

    Axonal chronic injury in treatment-naïve HIV+ adults with asymptomatic neurocognitive impairment and its relationship with clinical variables and cognitive status.
    BMC Neurol 2018 May 10;18(1):66. Epub 2018 May 10.
    Department of Radiology, Beijing YouAn Hospital, Capital Medical University, No.8, Xi Tou Tiao, Youanmen Wai, Feng Tai District, Beijing, 100069, China.
    Background: HIV is a neurotropic virus, and it can bring about neurodegeneration and may even result in cognitive impairments. The precise mechanism of HIV-associated white matter (WM) injury is unknown. The effects of multiple clinical contributors on WM impairments and the relationship between the WM alterations and cognitive performance merit further investigation. Read More

    Cognition and bimanual performance in children with unilateral cerebral palsy: protocol for a multicentre, cross-sectional study.
    BMC Neurol 2018 May 8;18(1):63. Epub 2018 May 8.
    Victorian Paediatric Rehabilitation Service, Monash Children's Hospital, 246 Clayton Rd, Clayton, VIC, 3168, Australia.
    Background: Motor outcomes of children with unilateral cerebral palsy are clearly documented and well understood, yet few studies describe the cognitive functioning in this population, and the associations between the two is poorly understood. Using two hands together in daily life involves complex motor and cognitive processes. Impairment in either domain may contribute to difficulties with bimanual performance. Read More

    Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report.
    BMC Neurol 2018 May 8;18(1):64. Epub 2018 May 8.
    Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.
    Background: POEMS syndrome is a plasma cell disorder, which clinically manifests from paraneoplastic syndrome: polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. The most common ocular manifestation is optic disc swelling, whereas other ocular manifestations; cystoid macular edema, serous macular detachment, venous sinus thrombosis, infiltrative orbitopathy, uveitis, neovascularization of the disc, peripapillary choroidal neovascularization and optic disc drusen, had also been reported.

    Case Presentation: A 52-year-old Thai man presented with 5-day sudden painless visual loss in the left eye. Read More

    A case of hyperparathyroidism-associated parkinsonism successfully treated with cinacalcet hydrochloride, a calcimimetic.
    BMC Neurol 2018 May 7;18(1):62. Epub 2018 May 7.
    Department of Cerebrovascular Medicine, Stroke Center, Steel Memorial Yawata Hospital, Kitakyushu, Japan.
    Background: Some metabolic disorders, including abnormal calcium metabolism, can develop and worsen parkinsonism. However, whether hyperparathyroidism can cause parkinsonism remains controversial.

    Case Presentation: An 83-year-old woman with a history of right thalamic hemorrhage and drug-induced parkinsonism, was admitted due to worsening of parkinsonian symptoms including mask-like face, bradykinesia, freezing of gait, and rigidity. Read More

    Association between different acute stroke therapies and development of post stroke seizures.
    BMC Neurol 2018 May 3;18(1):61. Epub 2018 May 3.
    Melbourne Brain Centre, Royal Melbourne Hospital and Department of Neurology, University of Melbourne, Parkville, Melbourne, Australia.
    Background: Epilepsy is a major complication of stroke. We aimed to establish whether there is an association between intravenous thrombolysis, intra-arterial thrombolysis and post stroke seizure (PSS) development. Improved understanding of the relationship between reperfusion therapies and seizure development may improve post-stroke monitoring and follow-up. Read More

    Altered cerebral glucose metabolism normalized in a patient with a pediatric autoimmune neuropsychiatric disorder after streptococcal infection (PANDAS)-like condition following treatment with plasmapheresis: a case report.
    BMC Neurol 2018 May 2;18(1):60. Epub 2018 May 2.
    Klinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Background: Pediatric autoimmune neuropsychiatric disorder after streptococcal infection (PANDAS) is a specific autoimmune response to group-A streptococcal infections in children and adolescents with a sudden onset of obsessive-compulsive disorders or tic-like symptoms. Cerebral metabolic changes of patients have not yet been observed.

    Case Presentation: We present a case of an 18-year old male with a PANDAS-like condition after developing tic-like symptoms and involuntary movements three weeks after cardiac surgery. Read More

    Ventriculoperitoneal shunts in non-HIV cryptococcal meningitis.
    BMC Neurol 2018 May 1;18(1):58. Epub 2018 May 1.
    Department of Neurology, the Third Affiliated Hospital of Sun Yat-Sen University, 600# Tianhe Road, Guangzhou, 510630, Guangdong, China.
    Background: Persistent and uncontrollable intracranial hypertension (ICH) and difficulty in reducing Cryptococcus count are severe problems in cryptococcal meningitis (CM) patients. The therapeutic effects of ventriculoperitoneal shunts (VPS) in non-HIV CM patients are not fully known, and the procedure is somewhat unusual. Here, our study offers a review to investigate the role of VPS in non-HIV CM. Read More

    Severe localised granulomatosis with polyangiitis (Wegener's granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review.
    BMC Neurol 2018 May 1;18(1):59. Epub 2018 May 1.
    Department of Rheumatology, The Royal London and Mile End Hospitals, Barts Health NHS Trust, Bancroft Road, London, E1 4DG, UK.
    Background: Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis) is a multisystem vasculitis of small- to medium-sized blood vessels. Cranial involvement can result in cranial nerve palsies and, rarely, pituitary infiltration.

    Case Presentation: We describe the case of a 32 year-old woman with limited but severe GPA manifesting as progressive cranial nerve palsies and pituitary dysfunction. Read More

    Platelet activation and aggregation after aneurysmal subarachnoid hemorrhage.
    BMC Neurol 2018 Apr 28;18(1):57. Epub 2018 Apr 28.
    Anesthesiology and Critical Care Department, Lariboisière Hospital, Paris, France.
    Background: Endovascular techniques have proven beneficial in the treatment of aneurysmal subarachnoid hemorrhage (aSAH), but with high risk of arterial clotting, emboli and dissection. Platelet activation and alterations in hemostasis may contribute to these complications. We investigated platelet activation and aggregation pathways in aSAH patients who underwent endovascular treatment. Read More

    The behavioural variant frontotemporal dementia phenocopy syndrome is a distinct entity - evidence from a longitudinal study.
    BMC Neurol 2018 Apr 28;18(1):56. Epub 2018 Apr 28.
    Brain and Mind Centre, University of Sydney, Sydney, NSW, 2050, Australia.
    Background: This study aimed to i) examine the frequency of C9orf72 expansions in a cohort of patients with the behavioural variant frontotemporal dementia (bvFTD) phenocopy syndrome, ii) observe outcomes in a group of phenocopy syndrome with very long term follow-up and iii) compare progression in a cohort of patients with the phenocopy syndrome to a cohort of patients with probable bvFTD.

    Methods: Blood was obtained from 16 phenocopy cases. All met criteria for possible bvFTD and were labeled as phenocopy cases if they showed no functional decline, normal cognitive performance on the Addenbrooke's Cognitive Examination-Revised (ACE-R) and a lack of atrophy on brain imaging, over at least 3 years of follow-up. Read More

    Case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito.
    BMC Neurol 2018 Apr 27;18(1):55. Epub 2018 Apr 27.
    Hospital Carlos Andrade Marín, Av. 18 de Septiembre y Ayacucho, Quito, Ecuador.
    Background: Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder that affects mammals and humans. The prevalence of this disease in the United States is 0.5 to 1 per million inhabitants. Read More

    Mediating effects of burden on quality of life for caregivers of first-time stroke patients discharged from the hospital within one year.
    BMC Neurol 2018 Apr 25;18(1):50. Epub 2018 Apr 25.
    School of Nursing, College of Medicine, Chang Gung University, No. 259, Wenhwa 1st Road, Guishan Dist., Taoyuan City, 33302, Taiwan.
    Background: Caregiver burden may be either a predictor or an outcome of caregiver quality of life (QoL). Patient or caregiver factors that directly affect caregiver QoL, predictors that are simultaneously shared with caregiver burden and QoL, and factors that affect caregiver QoL through caregiver burden are not well understood. This study explored predictors of caregiver QoL and identified whether caregiver burden is a mediator for caregivers of first-time stroke patients. Read More

    Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: a case report and literature review.
    BMC Neurol 2018 Apr 25;18(1):54. Epub 2018 Apr 25.
    Department of Psychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
    Background: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is a very rare finding. Read More

    Pleocytosis in a patient with relapsing polychondritis accompanied by meningoencephalitis: a case report.
    BMC Neurol 2018 Apr 25;18(1):53. Epub 2018 Apr 25.
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China.
    Background: Relapsing polychondritis (RP) is an uncommon immune-related disease with unknown causes. It is characterized by inflammation of cartilaginous or non-cartilaginous structures, such as the ears, nose, respiratory tract, eyes, and joints. Neurological involvement is rare in RP. Read More

    Case of convulsive seizure developing during electroretinographic recordings: a case report.
    BMC Neurol 2018 Apr 25;18(1):52. Epub 2018 Apr 25.
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, 260-8670, Japan.
    Background: To present our findings in a case of convulsive seizures and loss of consciousness that developed during recording electroretinograms (ERG).

    Case Presentation: A 34-year-old man had reduced vision in his left eye for about 15 years, and night blindness for about two years. His visual acuity was 20/15 in the right eye and 20/50 in the left eye. Read More

    High resolution magnetic resonance imaging in pathogenesis diagnosis of single lenticulostriate infarction with nonstenotic middle cerebral artery, a retrospective study.
    BMC Neurol 2018 Apr 25;18(1):51. Epub 2018 Apr 25.
    Department of Radiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Hepingli, Beijing, 100029, China.
    Background: It is usually difficult to identify stroke pathogenesis for single lenticulostriate infarction with nonstenotic middle cerebral artery (MCA). Our aim is to differentiate the two pathogeneses, non-branch atheromatous small vessel disease and branch atheromatous disease (BAD) by high-resolution magnetic resonance imaging (HR-MRI).

    Methods: Thirty-two single lenticulostriate infarction patients with nonstenotic MCA admitted to the China-Japan Friendship Hospital from December 2014 to August 2017 were enrolled for retrospective analysis. Read More

    Dose effects of mycophenolate mofetil in Chinese patients with neuromyelitis optica spectrum disorders: a case series study.
    BMC Neurol 2018 Apr 23;18(1):47. Epub 2018 Apr 23.
    Department of Neurology, China-Japan Friendship Hospital, #2 Yinghuayuan East Street, Chaoyang District, Beijing, 100029, China.
    Background: Neuromyelitis optica (NMO) spectrum disorder (NMOSD) is a devastating autoimmune inflammatory disorder of the central nervous system, which can result in blindness or paralysis. Currently, there is a dire need for new treatment options in the clinic. Several case series have shown that mycophenolate mofetil (MMF) may be an effective treatment for NMOSD patients. Read More

    Predictors of post-stroke fever and infections: a systematic review and meta-analysis.
    BMC Neurol 2018 Apr 23;18(1):49. Epub 2018 Apr 23.
    Department of Neurology, School of Medical Sciences, Örebro University, Örebro, Sweden.
    Background: Fever after stroke is common, and often caused by infections. In the current study, we aimed to test the hypothesis that pneumonia, urinary tract infection and all-cause fever (thought to include at least some proportion of endogenous fever) have different predicting factors, since they differ regarding etiology.

    Methods: PubMed was searched systematically for articles describing predictors for post-stroke pneumonia, urinary tract infection and all-cause fever. Read More

    Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency.
    BMC Neurol 2018 Apr 23;18(1):48. Epub 2018 Apr 23.
    Department of Paediatric Endocrinology and Diabetes, Marmara University, Fevzi Cakmak Mh. Mimar Sinan Cd.No 41., Ustkaynarca/Pendik, 34899, Istanbul, Turkey.
    Background: Congenital sphingosine-1-phosphate (S1P) lyase deficiency due to biallelic mutations in SGPL1 gene has recently been described in association with primary adrenal insufficiency and steroid-resistant nephrotic syndrome. S1P lyase, on the other hand, is therapeutically inhibited by fingolimod which is an oral drug for relapsing multiple sclerosis (MS). Effects of this treatment on adrenal function has not yet been evaluated. Read More

    Does burst-suppression achieve seizure control in refractory status epilepticus?
    BMC Neurol 2018 Apr 21;18(1):46. Epub 2018 Apr 21.
    Epidemiology Unit, Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
    Background: The general principles in the administration of anesthetic drugs entail not only the suppression of seizure activity but also the achievement of electroencephalography burst suppression (BS). However, previous studies have reported conflicting results, possibly owing to the inclusion of various anesthetic agents, not all patients undergoing continuous electroencephalography (cEEG), and the inclusion of anoxic encephalopathy. This study aimed to analyze the effects of midazolam-induced BS on the occurrence outcomes in refractory status epilepticus patients. Read More

    Why does my patient's basilar artery continue to grow? A four-year case study of a patient with symptoms of vertebrobasilar dolichoectasia.
    BMC Neurol 2018 Apr 20;18(1):45. Epub 2018 Apr 20.
    Department of Image, People's Hospital of Zhengzhou Affiliated to Southern Medical University, Zhengzhou, China.
    Background: Vertebrobasilar dolichoectasia (VBD) is a clinical entity associated with ischemic stroke, compression of cranial nerves or brainstem, and hydrocephalus. There have been relatively few studies following the progression of VBD in patients presenting with a variety of diverse clinical features.

    Case Presentation: Here, we report a case study of a male with progressive VBD who was followed from November 2012 to December 2016. Read More

    Tacrolimus-induced parkinsonism in a patient after liver transplantation - case report.
    BMC Neurol 2018 Apr 20;18(1):44. Epub 2018 Apr 20.
    Second Department of Neurology, Comenius University, Limbova 5, 833 05, Bratislava, Slovakia.
    Background: Hepatic encephalopathy may manifest by a wide spectrum of neuropsychiatric symptoms, including cognitive impairment, seizures or extrapyramidal symptoms. The liver transplant can lead to improvement of the signs of encephalopathy but subsequent immunosuppressive treatment might possess pronounced neurotoxicity.

    Case Presentation: We present a case report of a patient with chronic liver disease who developed signs of Parkinsonism after an orthotopic liver transplant, with consecutive immunosuppressant treatment with tacrolimus. Read More

    Comparison of electroencephalographic changes in response to acute electrical and thermal stimuli with the tail flick and hot plate test in rats administered with opiorphin.
    BMC Neurol 2018 Apr 19;18(1):43. Epub 2018 Apr 19.
    Massey University, Institute of Veterinary, Animal and Biomedical Sciences, Palmerston North, New Zealand.
    Background: The objective of this study was to compare the changes in the electroencephalogram (EEG) in response to noxious stimuli with tail flick and hot plate responses of rats administered opiorphin.

    Methods: Female Sprague -Dawley rats (n = 8 per group) randomly received intravenous (IV) injection of morphine (1 mg/kg,) or opiorphin (2 mg/kg,) or saline (0.5 ml,) in each of the three testing methods (EEG, tail flick and hot plate). Read More

    Idiopathic basal ganglia calcification associated with cerebral micro-infarcts: a case report.
    BMC Neurol 2018 Apr 17;18(1):42. Epub 2018 Apr 17.
    Department of Neurosurgery, Yamaguchi University School of Medicine, 1-1-1, Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
    Background: Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction due to impairment of cerebrovascular reactivity based on single-photon emission computed tomography (SPECT) with acetazolamide challenge.

    Case Presentation: A 66-year-old male presented with right conjugate deviation, right hemiparesis and total aphasia due to a convulsive seizure. Read More

    The cold pressor test in interictal migraine patients - different parasympathetic pupillary response indicates dysbalance of the cranial autonomic nervous system.
    BMC Neurol 2018 Apr 16;18(1):41. Epub 2018 Apr 16.
    Department of Neurology, University Hospital, LMU Munich, Campus Großhadern, Marchioninistr. 15, 81377, Munich, Germany.
    Background: Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous system. In the present study, we explicitly aimed to assess the cranial ANS in migraine patients compared to healthy controls by applying the cold pressor test to a cohort of migraine patients in the interictal phase and measuring the pupillary response.

    Methods: In this prospective observational study, a strong sympathetic stimulus was applied to 20 patients with episodic migraine in the interictal phase and 20 matched controls without migraine, whereby each participant dipped the left hand into ice-cold (4 °C) water for a maximum of 5 min (cold pressor test). Read More

    ACUDIN - ACUpuncture and laser acupuncture for treatment of DIabetic peripheral Neuropathy: a randomized, placebo-controlled, partially double-blinded trial.
    BMC Neurol 2018 Apr 13;18(1):40. Epub 2018 Apr 13.
    HanseMerkur Center for Traditional Chinese Medicine at the University Medical Center Hamburg-Eppendorf, Martinistrasse 52, House O55, 20246, Hamburg, Germany.
    Background: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus with significant clinical sequelae that can affect a patient's quality of life. Metabolic and microvascular factors are responsible for nerve damage, causing loss of nerve function, numbness, painful sensory symptoms, and muscle weakness. Therapy is limited to anti-convulsant or anti-depressant drugs for neuropathic pain and paresthesia. Read More

    Protocol for promoting recovery optimization of walking activity in stroke (PROWALKS): a randomized controlled trial.
    BMC Neurol 2018 Apr 12;18(1):39. Epub 2018 Apr 12.
    Department of Physical Therapy, University of Delaware, Newark, DE, 19713, USA.
    Background: Stroke survivors are more physically inactive than even the most sedentary older adults, and low activity is associated with increased risk of recurrent stroke, medical complications, and mortality. We hypothesize that the combination of a fast walking intervention that improves walking capacity, with a step activity monitoring program that facilitates translation of gains from the clinic to the "real-world", would generate greater improvements in real world walking activity than with either intervention alone.

    Methods: Using a single-blind randomized controlled experimental design, 225 chronic (> 6 months) stroke survivors complete 12 weeks of fast walking training, a step activity monitoring program or a fast walking training + step activity monitoring program. Read More

    Personalized objects can optimize the diagnosis of EMCS in the assessment of functional object use in the CRS-R: a double blind, randomized clinical trial.
    BMC Neurol 2018 Apr 12;18(1):38. Epub 2018 Apr 12.
    International Vegetative State and Consciousness Science Institute, Hangzhou Normal University, Hangzhou, China.
    Background: Behavioral assessment has been acted as the gold standard for the diagnosis of disorders of consciousness (DOC) patients. The item "Functional Object Use" in the motor function sub-scale in the Coma Recovery Scale-Revised (CRS-R) is a key item in differentiating between minimally conscious state (MCS) and emergence from MCS (EMCS). However, previous studies suggested that certain specific stimuli, especially something self-relevant can affect DOC patients' scores of behavioral assessment scale. Read More

    Progressive multifocal leukoencephalopathy associated with thymoma with immunodeficiency: a case report and literature review.
    BMC Neurol 2018 Apr 10;18(1):37. Epub 2018 Apr 10.
    Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-Tsukurimichi, Aomori, 030-8551, Japan.
    Background: The development of progressive multifocal leukoencephalopathy (PML) is associated with severe cellular immunosuppression. Good's syndrome (GS) is a rare immunodeficiency syndrome related to thymoma, with the development of humoral as well as cellular immunosuppression; however, there are few reports of PML due to GS. One report suggested that the neurological symptoms of PML related to thymoma may be improved by a reduction of immunosuppressive therapy for myasthenia gravis (MG). Read More

    Subarachnoid hemorrhage after transient global amnesia caused by cerebral venous congestion: case report.
    BMC Neurol 2018 Apr 6;18(1):36. Epub 2018 Apr 6.
    Department of Neurosurgery, Suiseikai Kajikawa Hospital, 1-1-23, Higashisendamachi, Naka-ku, Hiroshima, 730-0053, Hiroshima, Japan.
    Background: Transient global amnesia is reported to be caused by cerebral venous congestion. Internal jugular venous flow reversal in particular with the Valsalva maneuver leads to cerebral venous congestion. In addition, Valsalva maneuver can also induce subarachnoid hemorrhage. Read More

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