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    Changes in bone mineral density after total parathyroidectomy without autotransplantation in the end-stage renal disease patients with secondary hyperparathyroidism.
    BMC Nephrol 2018 Jun 15;19(1):142. Epub 2018 Jun 15.
    Department of Nephrology, Second Affiliated Hospital of Nanjing Medical University, 262 Zhongshan North Road, Nanjing, Jiangsu Province, China.
    Background: The patients with secondary hyperparathyroidism (SHPT) usually had reduced bone mineral density, which might lead to a substantial increase in osteoporosis, fracture and mortality. Although surgical intervention is effective in reducing parathyroid hormone (PTH) levels in suitable candidates refractory to medical therapy, the effect of surgery on bone mass changes still requires further evaluation. Thus, the aim of this study was to evaluate the characteristics of BMD changes after total parathyroidectomy (PTX) without autotransplantation and its associated factors. Read More

    IPR-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model.
    BMC Nephrol 2018 Jun 15;19(1):140. Epub 2018 Jun 15.
    Department of Biostatistics, Peking University First Hospital, Beijing, 100034, China.
    Background: The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IPR)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium uniporter (MCU) calcium regulation axis, which is located at sites of endoplasmic reticulum (ER) mitochondria coupling, in the mechanism of podocyte apoptosis is unclear. This study aimed to understand the roles of this axis in podocyte apoptosis and explore potential targets for podocyte protection. Read More

    A case of immunotactoid glomerulopathy with false-negative IgG staining.
    BMC Nephrol 2018 Jun 15;19(1):143. Epub 2018 Jun 15.
    Department of Nephrology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 7348551, Japan.
    Background: Immunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by microtubular deposits. Immunofluorescence findings are necessary to differentiate ITG from other proliferative glomerular diseases. The characteristic tubular structure on electron microscopy is essential for a definitive diagnosis, and the diameter of the structure has been traditionally used for differentiating between ITG and other types of glomerulonephritis with organized deposits. Read More

    Severe renal Fanconi and management strategies in Arthrogryposis-Renal dysfunction-Cholestasis syndrome: a case report.
    BMC Nephrol 2018 Jun 15;19(1):144. Epub 2018 Jun 15.
    Pediatric Nephrology, Hospital Universitario Vall d'Hebron, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
    Background: Arthrogryposis-Renal dysfunction-Cholestasis syndrome (ARC, MIM#208085) is a rare multisystem disease due to mutations in the VPS33B and VIPAR genes, both involved in maintaining apical-basolateral cell polarity. The correlation between mutations and phenotype in the ARC Syndrome is not well described. We report on a 6 year old patient who presented with severe renal Fanconi as first manifestation of ARC related to a combined de novo mutation in the VPS33B gene. Read More

    End-stage renal disease treated in Provence-Alpes Côte d'Azur: 12-years follow-up and forecast to the year 2030.
    BMC Nephrol 2018 Jun 15;19(1):141. Epub 2018 Jun 15.
    Aix-Marseille University, EA 3279, Public Health, Chronic Diseases and Quality of Life research Unit, 27 Boulevard Jean Moulin, 13385, Marseille cedex 5, France.
    Background: This study describes the time trend of renal replacement therapy for end-stage renal disease (ESRD) in the Provence-Alpes Côte d'Azur region (PACA) between 2004 and 2015, and forecasts up to 2030.

    Methods: A longitudinal study was conducted on all ESRD patients treated in PACA and recorded in the French Renal Epidemiology and Information Network (REIN) during this period. Time trends and forecasts to 2030 were analyzed using Poisson regression models. Read More

    Risk factors for infectious complications of ANCA-associated vasculitis: a cohort study.
    BMC Nephrol 2018 Jun 14;19(1):138. Epub 2018 Jun 14.
    National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China.
    Background: Severe infections are common complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal involvement. We investigated the clinical characteristics and risk factors of severe infection in Chinese patients with AAV after immunosuppressive therapy.

    Methods: A total of 248 patients with a new diagnosis of ANCA-associated vasculitis were included in this study. Read More

    Prevalence and associated factors of protein- energy wasting among patients with chronic kidney disease at Mulago hospital, Kampala-Uganda: a cross-sectional study.
    BMC Nephrol 2018 Jun 14;19(1):139. Epub 2018 Jun 14.
    Department of Physiology, College of Health Sciences, School of Biomedical sciences, Makerere University, P.O Box 7076, Kampala, Uganda.
    Background: Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20-25% of patients with chronic kidney disease and can lead to a high morbidity and mortality rate. Read More

    Rapid calcium loss may cause arrhythmia in hemofiltration with regional citrate anticoagulation: a case report.
    BMC Nephrol 2018 Jun 14;19(1):136. Epub 2018 Jun 14.
    Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
    Background: Renal replacement therapy (RRT) with regional citrate anticoagulation (RCA) is an important therapeutic approach for refractory hypercalcemia complicated with renal failure. However, RCA has the potential to induce arrhythmia caused by rapid calcium loss. We report a case of arrhythmia associated with rapid calcium loss during RCA-RRT. Read More

    A comparison of temporal artery thermometers with internal blood monitors to measure body temperature during hemodialysis.
    BMC Nephrol 2018 Jun 14;19(1):137. Epub 2018 Jun 14.
    Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, AB, T2N 4N1, Canada.
    Background: Thermometers that measure core (internal) body temperature are the gold standard for monitoring temperature. Despite that most modern hemodialysis machines are equipped with an internal blood monitor that measures core body temperature, current practice is to use peripheral thermometers. A better understanding of how peripheral thermometers compare with the dialysis machine thermometer may help guide practice. Read More

    Anemia and mortality in patients with nondialysis-dependent chronic kidney disease.
    BMC Nephrol 2018 Jun 11;19(1):135. Epub 2018 Jun 11.
    GlaxoSmithKline, Collegeville, PA, USA.
    Background: A combination of safety concerns and labeling changes impacted use of erythropoiesis-stimulating agents (ESAs) in renal anemia. Data regarding contemporary utilization in pre-dialysis chronic kidney disease (CKD) are lacking.

    Methods: Electronic healthcare records and medical claims data of pre-dialysis CKD patients were aggregated from a large US managed care provider (2011-13). Read More

    Non-recovery from dialysis-requiring acute kidney injury and short-term mortality and cardiovascular risk: a cohort study.
    BMC Nephrol 2018 Jun 11;19(1):134. Epub 2018 Jun 11.
    Division of Research, Kaiser Permanente Northern California, Oakland, CA, 94612, USA.
    Background: The high mortality and cardiovascular disease (CVD) burden in patients with end-stage renal disease (ESRD) is well-documented. Recent literature suggests that acute kidney injury is also associated with CVD. It is unknown whether patients with incident ESRD due to dialysis-requiring acute kidney injury (AKI-D) are at higher short-term risk for death and CVD events, compared with incident ESRD patients without preceding AKI-D. Read More

    Sex differences in acute kidney injury requiring dialysis.
    BMC Nephrol 2018 Jun 8;19(1):131. Epub 2018 Jun 8.
    Department of Renal Medicine, Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3NE, UK.
    Background: Female sex has been included as a risk factor in models developed to predict the risk of acute kidney injury (AKI) associated with cardiac surgery, aminoglycoside nephrotoxicity and contrast-induced nephropathy. The commentary acompanying the Kidney Disease Improving Global Outcomes Clinical Practice Guideline for Acute Kidney Injury concludes that female sex is a shared susceptibility factor for acute kidney injury based on observations that female sex is associated with the development of hospital-acquired acute kidney injury. In contrast, female sex is reno-protective in animal models. Read More

    The complex treatment including rituximab in the Management of Catastrophic Antiphospholid Syndrome with renal involvement.
    BMC Nephrol 2018 Jun 8;19(1):132. Epub 2018 Jun 8.
    Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, Szaserów 128, 04-141, Warsaw, Poland.
    Background: Catastrophic antiphospholipid syndrome (CAPS) is a rare, life-threatening form of antiphospholipid syndrome (APS) involving many organs and leading to their insufficiency. The pathogenesis of CAPS is associated with the presence of antiphospholipid antibodies (aPL). Typical therapy includes anticoagulation, glucocorticoids, therapeutic plasma exchanges and/or intravenous immunoglobulin. Read More

    C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.
    BMC Nephrol 2018 Jun 8;19(1):129. Epub 2018 Jun 8.
    Nephrology Department, Carlos Haya Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Avda. Carlos Haya s/n, E-29010, Malaga, Spain.
    Background: Morbidity associated with monoclonal gammopathy of renal significance is high due to the severe renal lesions and the associated systemic alterations. Accordingly, early diagnosis is fundamental, as is stopping the clonal production of immunoglobulins using specific chemotherapy.

    Case Presentation: A 75-year-old man with chronic renal disease of unknown origin since 2010 experienced rapid worsening of renal function over a period of 6 mos. Read More

    Interviews of living kidney donors to assess donation-related concerns and information-gathering practices.
    BMC Nephrol 2018 Jun 8;19(1):130. Epub 2018 Jun 8.
    Department of Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 34, Baltimore, MD, 21205, USA.
    Background: Efforts are underway to improve living kidney donor (LKD) education, but current LKD concerns and information-gathering preferences have not been ascertained to inform evidence-based resource development. As a result, prior studies have found that donors desire information that is not included in current informed consent and/or educational materials.

    Methods: We conducted semi-structured interviews with 50 LKDs who donated at our center to assess (1) concerns about donation that they either had personally before or after donation or heard from family members or friends, (2) information that they had desired before donation, and (3) where they sought information about donation. Read More

    Red urine, updated for the nephrologist: a case report.
    BMC Nephrol 2018 Jun 8;19(1):133. Epub 2018 Jun 8.
    Department of Nephrology and Renal Transplantation, Hôpital universitaire de la Conception, AP-HM, Marseille, France.
    Background: Sickle cell trait is not completely benign, and some renal complications can occur. The baseline rate of admission for gross hematuria in normal males carrying the sickle cell trait is 2%.

    Case Presentation: A 35-year-old non-smoking African man experienced a 2-week history of painless, profuse and persistent gross hematuria. Read More

    Emergence of an Israel faith-based community organization facilitating live donor kidney transplantation.
    BMC Nephrol 2018 Jun 7;19(1):128. Epub 2018 Jun 7.
    Department of Economics, Ariel University, 44837, Ariel, Israel.
    Background: The 2014 Consensus Conference on Best Practices in Living Kidney Donations recognized live donor kidney transplantation as the best treatment for late-stage kidney disease, yielding superior graft and patient survival, improved quality of life, fewer requirements for dialysis and increased cost-effectiveness compared to deceased donor kidney transplantation. Yet in spite of the excellent results of living kidney donation, the annual number of living kidney donors is declining in many countries, including the United States. In Israel, a non-profit organization, Matnat Chaim ("Gift of Life" in Hebrew), a faith-based initiative, has emerged as a major force for arranging living donor kidney transplantation mainly by facilitating altruistic living unrelated donor transplantation. Read More

    The effect of continuity of care on the incidence of end-stage renal disease in patients with newly detected type 2 diabetic nephropathy: a retrospective cohort study.
    BMC Nephrol 2018 Jun 5;19(1):127. Epub 2018 Jun 5.
    Institute of Health Services Research, Yonsei University, Seoul, Republic of Korea.
    Background: Diabetic nephropathy requires periodic monitoring, dietary modification, and early intervention to prevent the disease severity within limited resource settings. To emphasize the importance of continuous care for chronic diseases, various studies have focused on the association between continuity of care (COC) and common adverse outcomes. However, studies aimed at understanding the effect of COC on the incidence of chronic diseases, such as end-stage renal disease (ESRD), are few. Read More

    Patient and treatment characteristics associated with patient activation in patients undergoing hemodialysis: a cross-sectional study.
    BMC Nephrol 2018 Jun 1;19(1):126. Epub 2018 Jun 1.
    KU Leuven, Department of Public Health and Primary Care, Academic Centre for General Practice, Kapucijnenvoer 33 (box 7001), B-3000, Leuven, Belgium.
    Background: Patient activation is associated with better outcomes and lower costs. Although the concept is widely investigated, little attention was given to patient activation and its predictors in patients undergoing hemodialysis. Hence, we aimed to investigate the level of patient activation and aimed to determine patient- and treatment-related predictors of activation in patients undergoing hemodialysis. Read More

    Burden of chronic kidney disease on the African continent: a systematic review and meta-analysis.
    BMC Nephrol 2018 Jun 1;19(1):125. Epub 2018 Jun 1.
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.
    Background: Accurate contemporary data on the burden of Chronic Kidney Disease (CKD) on the African continent are lacking. We determined the prevalence of CKD in adult populations living in Africa, and variations by stage, gender, estimated Glomerular Filtration Rate (eGFR) equation, and residence.

    Methods: For this systematic review, we searched multiple electronic databases for original studies on CKD prevalence reported from January 1, 2000 to December 31, 2016. Read More

    Renal function markers and insulin sensitivity after 3 years in a healthy cohort, the EGIR-RISC study.
    BMC Nephrol 2018 May 31;19(1):124. Epub 2018 May 31.
    CESP team5, Faculty of Medicine - University Paris-South, Faculty of Medicine - University Versailles-St Quentin, INSERM U1018, University Paris-Saclay, Villejuif, France.
    Background: People with chronic renal disease are insulin resistant. We hypothesized that in a healthy population, baseline renal function is associated with insulin sensitivity three years later.

    Methods: We studied 405 men and 528 women from the European Group for the study of Insulin Resistance - Relationship between Insulin Sensitivity and Cardiovascular disease cohort. Read More

    Two in One: Epithelioid angiomyolipoma within a classic kidney angiomyolipoma - a case report.
    BMC Nephrol 2018 May 30;19(1):123. Epub 2018 May 30.
    Ultrasound Learning Center EFSUMB, Klinik Hirslanden, Zürich, Switzerland.
    Background: Epithelioid angiomyolipoma is defined as potentially malignant mesenchymal neoplasm, characterized by proliferating epithelioid cells, whereas classic angiomyolipoma, composed of fat, smooth muscle cells and dysmorphic vessels, is defined as a potentially benign. The usual or classic angiomyolipoma is often found incidentally on imaging studies, relatively easily identified due to the presence of fat, in contrast to the epithelioid angiomyolipoma that can pose diagnostic challenges.

    Case Presentation: We report a 51-year-old female patient in which an ultrasonography examination showed a solid mass close to the right renal pelvis with hypoechoic and hyperechoic areas. Read More

    Anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with detection of myeloperoxidase and phospholipase A receptor in membranous nephropathy-lesions: report of two patients with microscopic polyangiitis.
    BMC Nephrol 2018 May 23;19(1):120. Epub 2018 May 23.
    Department of Nephrology and Endocrinology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
    Background: Podocyte phospholipase A receptor (PLAR) is a major target antigen in idiopathic adult membranous nephropathy (MN). Histological PLAR staining in the renal tissue has proven to be useful for the detection of idiopathic MN. However, glomerular PLAR deposits have also been recently observed in several patients with secondary MN, such as hepatitis B virus-associated, hepatitis C virus-associated, and neoplasm-associated MN. Read More

    Perspectives on clinical use of bioimpedance in hemodialysis: focus group interviews with renal care professionals.
    BMC Nephrol 2018 May 23;19(1):121. Epub 2018 May 23.
    Department of Medical Sciences, University Hospital, Entrance 40, 751 85, Uppsala, Sweden.
    Background: Inadequate volume control may be a main contributor to poor survival and high mortality in hemodialysis patients. Bioimpedance measurement has the potential to improve fluid management, but several dialysis centers lack an agreed fluid management policy, and the method has not yet been implemented. Our aim was to identify renal care professionals' perceived barriers and facilitators for use of bioimpedance in clinical practice. Read More

    Liddle's-like syndrome associated with nephrotic syndrome secondary to membranous nephropathy: the first case report.
    BMC Nephrol 2018 May 23;19(1):122. Epub 2018 May 23.
    Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, 1-4-1, Morioka, 020-0066, Japan.
    Background: Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldosteronism, and a potassium-sparing diuretics (triamterene or amiloride) can drastically improves the disease condition. Although elderly patients having these characteristics were considered to have Liddle's syndrome or Liddle's-like syndrome, no previous report has indicated that Liddle's-like syndrome could be caused by nephrotic syndrome of primary glomerular disease, which is characterized by urinary excretion of > 3 g of protein/day plus edema and hypoalbuminemia, or has explained how the activity function of ENaC could be affected in the setting of high proteinuria. Read More

    Use of synthetic adrenocorticotropic hormone in patients with IgA nephropathy.
    BMC Nephrol 2018 May 23;19(1):118. Epub 2018 May 23.
    Nephrology and Hypertension, Mayo Clinic, 200 First Street, Minnesota, Rochester, MN, 55905, USA.
    Background: Synthetic adrenocorticotropic hormone (ACTH) has been demonstrated to be effective in patients with membranous nephropathy, minimal change disease and some histological subtypes of focal segmental glomerulosclerosis. Its clinical impact in patients with IgA nephropathy is currently unclear.

    Case Presentation: In this report, we describe the clinical use of ACTH in patients with IgA nephropathy. Read More

    Different patterns of inflammatory and angiogenic factors are associated with peritoneal small solute transport and peritoneal protein clearance in peritoneal dialysis patients.
    BMC Nephrol 2018 May 23;19(1):119. Epub 2018 May 23.
    Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No.1630, Dongfang Road, Pudong New Area, Shanghai, 200127, China.
    Background: Both peritoneal small solute transport and peritoneal protein clearance are closely linked to outcomes in peritoneal dialysis (PD) patients. However, the associated factors of these two components are not fully understood so far. This study aimed to investigate the association between a panel of systemic and peritoneal inflammatory and angiogenic factors and peritoneal solute transport properties. Read More

    The association of angiogenic factors and chronic kidney disease.
    BMC Nephrol 2018 May 21;19(1):117. Epub 2018 May 21.
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, room 1504, New Orleans, LA, 70112, USA.
    Background: There are limited data on the associations of circulating angiogenic factors with chronic kidney disease (CKD). We investigate the associations of circulating vascular endothelial growth factor (VEGF)-A, angiopoietin-1, angiopoietin-1/VEGF-A ratio, VEGF receptor 1 (VEGFR-1), VEGFR-2, and pentraxin-3 with CKD.

    Methods: We recruited 201 patients with CKD and 201 community controls without CKD from the greater New Orleans area. Read More

    What is the impact of human leukocyte antigen mismatching on graft survival and mortality in renal transplantation? A meta-analysis of 23 cohort studies involving 486,608 recipients.
    BMC Nephrol 2018 May 18;19(1):116. Epub 2018 May 18.
    Department of Pediatrics, Peking University First Hospital, Beijing, China.
    Background: The magnitude effects of human leukocyte antigen (HLA) mismatching on post-transplant outcomes of kidney transplantation remain controversial. We aim to quantitatively assess the associations of HLA mismatching with graft survival and mortality in adult kidney transplantation.

    Methods: We searched PubMed, EMBASE and the Cochrane Library from their inception to December, 2016. Read More

    Early renal damage among children living in the region of highest burden of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka.
    BMC Nephrol 2018 May 16;19(1):115. Epub 2018 May 16.
    Department of Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.
    Background: Chronic kidney disease of unknown origin (CKDu) in Sri Lanka is grouped with several other epidemics of similar nature across the world as Chronic Interstitial Nephritis in Agricultural Communities (CINAC). In CKDu endemic countries, the focus has mainly been on adults. We hypothesized that studying distribution and factors associated with elevated urine albumin to creatinine ratio (UACR), an early marker of kidney injury, among children living in a CKDu endemic area may provide important clues about the onset and progression of the disease. Read More

    COL4A5 and LAMA5 variants co-inherited in familial hematuria: digenic inheritance or genetic modifier effect?
    BMC Nephrol 2018 May 16;19(1):114. Epub 2018 May 16.
    Molecular Medicine Research Center, Department of Biological Sciences, University of Cyprus, 1, University Avenue, 2109, Nicosia, Cyprus.
    Background: About 40-50% of patients with familial microscopic hematuria (FMH) caused by thin basement membrane nephropathy (TBMN) inherit heterozygous mutations in collagen IV genes (COL4A3, COL4A4). On long follow-up, the full phenotypic spectrum of these patients varies a lot, ranging from isolated MH or MH plus low-grade proteinuria to chronic renal failure of variable degree, including end-stage renal disease (ESRD).

    Methods: Here, we performed Whole Exome Sequencing (WES) in patients of six families, presenting with autosomal dominant FMH, with or without progression to proteinuria and loss of renal function, all previously found negative for severe collagen IV mutations. Read More

    Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism.
    BMC Nephrol 2018 May 15;19(1):113. Epub 2018 May 15.
    Department of Nephrology, The Royal Melbourne Hospital, 300 Grattan St, Parkville, Victoria, 3050, Australia.
    Background: The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to assess effects of medication cessation on biochemical and clinical outcomes in dialysis patients, including changes to novel biomarkers such as calciprotein particles (CPP). CPP are nanoparticles of mineral and protein in the circulation associated with increased vascular calcification in patients with chronic kidney disease. Read More

    Full normalization of severe hypertension after parathryoidectomy - a case report and systematic review.
    BMC Nephrol 2018 May 11;19(1):112. Epub 2018 May 11.
    Dipartimento di Scienze Cliniche e Biologiche, Università di Torino, Turin, Italy.
    Background: Although the relationship between hyperparathyroidism and hypertension has been described for decades, the role of hyperparathyroidism in hypertension in dialysis is still unclear. Following the case of a severely hypertensive dialysis patient, in which parathyroidectomy (PTX) corrected the metabolic imbalance and normalized blood pressure (BP), we tried to contextualize our observation with a systematic review of the recent literature on the effect of PTX on BP.

    Case Presentation: A dialysis patient, aged 19 years at the time of this report, with chronic kidney disease (CKD) from childhood; he was an early-preterm baby with very low birth weight (910 g), and is affected by a so-far unidentified familial nephropathy. Read More

    The renal manifestations of type 4 familial partial lipodystrophy: a case report and review of literature.
    BMC Nephrol 2018 May 10;19(1):111. Epub 2018 May 10.
    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    Background: Lipodystrophy syndromes are rare disorders of variable body fat loss associated with potentially serious metabolic complications. Familial partial lipodystrophy (FPLD) is mostly inherited as an autosomal dominant disorder. Renal involvement has only been reported in a limited number of cases of FPLD. Read More

    Safety and effectiveness of low-protein diet supplemented with ketoacids in diabetic patients with chronic kidney disease.
    BMC Nephrol 2018 May 9;19(1):110. Epub 2018 May 9.
    Centro de Atención Nutricional Fresenius Kabi, Ciudad de México, Mexico.
    Background: The impact of the low-protein diet on nutrition in CKD diabetics is uncertain.

    Methods: The metabolic and nutritional effects of a low-protein (0.5-0. Read More

    Longitudinal analysis of cardiac structure and function in incident-automated peritoneal dialysis: comparison between icodextrin solution and glucose-based solution.
    BMC Nephrol 2018 May 8;19(1):109. Epub 2018 May 8.
    Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan.
    Background: This study aimed to evaluate the longitudinal changes in cardiac structure and function in incident-automated peritoneal dialysis (APD) patients.

    Methods: We conducted a 2-year prospective, randomized, open-label, parallel-group study to compare the efficacy of icodextrin solution versus glucose-based solution. Echocardiography was performed at baseline, 1 and 2 years. Read More

    The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity: a multicenter randomized, double-blind, clinical trial (the SPIREN trial).
    BMC Nephrol 2018 May 3;19(1):105. Epub 2018 May 3.
    Department of Nephrology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense C, Denmark.
    Background: Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple organs. Animal studies have indicated a beneficial effect of mineralocorticoid receptor antagonists preventing calcineurin inhibitor induced nephrotoxicity. Read More

    Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report.
    BMC Nephrol 2018 May 3;19(1):108. Epub 2018 May 3.
    Department of Nephrology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 7348551, Japan.
    Background: Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway. In most cases, C3 glomerulopathy manifests pathologically with membranoproliferative glomerulonephritis-like features. An association between C3 glomerulopathy and monoclonal gammopathy was recently reported in several cases, raising the possibility that C3 glomerulopathy is the underlying pathological process in monoclonal gammopathy of renal significance. Read More

    Urinothorax after ultrasonography-guided renal biopsy: a case report.
    BMC Nephrol 2018 May 3;19(1):104. Epub 2018 May 3.
    Department of Internal Medicine, Changwon Gyeongsang National University Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon-si, Gyeongsangnam-do, South Korea.
    Background: Urinothorax is defined as the presence of urine in the pleural space and is a rather rare cause of transudate pleural effusion. The potential etiologies are urinary tract obstruction and trauma. Diagnosis requires a high index of clinical suspicion and the condition is completely reversible following relief of underlying disease. Read More

    Effectiveness of informational decision aids and a live donor financial assistance program on pursuit of live kidney transplants in African American hemodialysis patients.
    BMC Nephrol 2018 May 3;19(1):107. Epub 2018 May 3.
    Department of Medicine, San Francisco General Hospital and University of California, San Francisco, CA, USA.
    Background: African Americans have persistently poor access to living donor kidney transplants (LDKT). We conducted a small randomized trial to provide preliminary evidence of the effect of informational decision support and donor financial assistance interventions on African American hemodialysis patients' pursuit of LDKT.

    Methods: Study participants were randomly assigned to receive (1) Usual Care; (2) the Providing Resources to Enhance African American Patients' Readiness to Make Decisions about Kidney Disease (PREPARED); or (3) PREPARED plus a living kidney donor financial assistance program. Read More

    Eculizumab as salvage therapy for recurrent monoclonal gammopathy-induced C3 glomerulopathy in a kidney allograft.
    BMC Nephrol 2018 May 3;19(1):106. Epub 2018 May 3.
    Department of Nephropathology, Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
    Background: Monoclonal gammopathy causes several kinds of renal pathology. A rare and special form is monoclonal gammopathy-induced C3 glomerulopathy (MG-C3G). Like idiopathic C3G, MG-C3G frequently leads to end-stage renal disease. Read More

    Biomarker enhanced risk prediction for development of AKI after cardiac surgery.
    BMC Nephrol 2018 May 2;19(1):102. Epub 2018 May 2.
    Division of Nephrology & Hypertension, Department of Medicine, University of Louisville School of Medicine, Donald Baxter Research Building, Rm 204C, 570 S. Preston Street, Louisville, KY, 40202, USA.
    Background: Acute kidney injury (AKI) is a common post-cardiac surgery complication and influences patient morbidity and prognosis. This study was designed to identify preoperative candidate urine biomarkers in patients undergoing cardiac surgery.

    Methods: A prospective cohort study of adults undergoing cardiac surgery at increased risk for AKI at a single hospital between July 2010 and September 2012 was performed. Read More

    Association of arterial stiffness and central hemodynamics with moderately reduced glomerular filtration rate in Chinese middle-aged and elderly community residents: a cross-sectional analysis.
    BMC Nephrol 2018 May 2;19(1):103. Epub 2018 May 2.
    Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China.
    Background: Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave velocity (cfPWV) is a significant factor associated with chronic kidney disease. However, whether cfPWV is associated with moderately reduced glomerular filtration rate (GFR) remains unclear. Read More

    Body weight definitions for evaluating a urinary diagnosis of acute kidney injury in patients with sepsis.
    BMC Nephrol 2018 May 2;19(1):101. Epub 2018 May 2.
    Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
    Background: We hypothesized that the use of actual body weight might lead to more frequent misdiagnosis of acute kidney injury (AKI) than when ideal body weight is used in underweight and/or obese patients. We examined which definition of body weight is most effective in establishing a urinary diagnosis of AKI in septic patients.

    Methods: Consecutive patients aged ≥ 20 years admitted to the intensive care unit of a university hospital between June 2011 and December 2016 were analyzed. Read More

    Functional status, pre-dialysis health and clinical outcomes among elderly dialysis patients.
    BMC Nephrol 2018 Apr 27;19(1):100. Epub 2018 Apr 27.
    Division of Nephrology and Hypertension, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, 45267, USA.
    Background: Elderly patients comprise the fastest growing population initiating dialysis in United States. The impact of poor functional status and pre-dialysis health status on clinical outcomes in elderly dialysis patients is not well studied.

    Methods: We studied a retrospective cohort of 49,645 incident end stage renal disease patients that initiated dialysis between January 1, 2008 and December 31, 2008 from the United States Renal Data System with linked Medicare data covering at least 2 years prior to dialysis initiation. Read More

    Factors associated with Health-Related Quality of Life in Kidney Transplant Recipients in France.
    BMC Nephrol 2018 Apr 27;19(1):99. Epub 2018 Apr 27.
    Laboratoire de Santé Publique, Faculté de Médecine, Université Aix-Marseille, 3279, Marseille, EA, France.
    Background: Health-Related Quality of Life (HRQoL) assessment after kidney transplantation has become an important tool in evaluating outcomes. This study aims to identify the associated factors with HRQoL among a representative sample size of Kidney Transplant Recipients (KTR) at the time of their inclusion in the study.

    Methods: Data of this cross-sectional design is retrieved from a longitudinal study conducted in five French kidney transplant centers in 2011, and included KTR aged 18 years with a functioning graft for at least 1 year. Read More

    Decision-making process in the pre-dialysis CKD patients: do anxiety, stress and depression matter?
    BMC Nephrol 2018 Apr 27;19(1):98. Epub 2018 Apr 27.
    Nephrology, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, São Paulo, Brazil.
    Background: The transition from pre-dialysis chronic kidney disease (CKD) to renal replacement therapy (RRT) is a stressful event. Anxiety, depression and stress are frequent conditions in this population, and might play a role on the choice of dialysis modality.

    Methods: This is a prospective study that included stages 4-5 CKD patients during a dialysis multi-disciplinary education program. Read More

    Correction to: The Ferumoxytol for Anemia of CKD Trial (FACT)-a randomized controlled trial of repeated doses of ferumoxytol or iron sucrose in patients on hemodialysis: background and rationale.
    BMC Nephrol 2018 Apr 26;19(1):97. Epub 2018 Apr 26.
    AMAG Pharmaceuticals, Inc., 1100 Winter Street, Waltham, MA, 02451, USA.
    Following publication of the original article [1], the authors reported that one of the authors' name is spelled incorrectly. In this Erratum the incorrect and correct author name are shown. The original publication of this article has been corrected. Read More

    Urinary excretion of uric acid is negatively associated with albuminuria in patients with chronic kidney disease: a cross-sectional study.
    BMC Nephrol 2018 Apr 24;19(1):95. Epub 2018 Apr 24.
    Department of Nephrology, Huadong Hospital affiliated to Fudan University, No. 221 West Yan'an Road, Shanghai, 200040, People's Republic of China.
    Background: Increasing evidence has shown that albuminuria is related to serum uric acid. Little is known about whether this association may be interrelated via renal handling of uric acid. Therefore, we aim to study urinary uric acid excretion and its association with albuminuria in patients with chronic kidney disease (CKD). Read More

    Factors influencing dialysis withdrawal: a scoping review.
    BMC Nephrol 2018 Apr 24;19(1):96. Epub 2018 Apr 24.
    School of Public Health and Health Systems, Faculty of Applied Health Sciences, University of Waterloo, Waterloo, ON, Canada.
    Background: Research on factors associated with dialysis withdrawal is scarce. This study examined the predictors that might influence rate of dialysis withdrawal. Existing literature is summarized, analyzed and synthesized to identify gaps in the literature with regard to the factors associated with dialysis withdrawal. Read More

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