2,231 results match your criteria BMC Nephrology[Journal]


Long-term peritoneal dialysis followed by kidney transplantation for Takayasu arteritis: a case report.

BMC Nephrol 2019 Apr 18;20(1):131. Epub 2019 Apr 18.

Division of Nephrology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan.

Background: Takayasu arteritis (TA) is a chronic vasculitis of unknown etiology that primarily affects large vessels. Although renal involvement is frequent in TA, patients with TA undergoing renal replacement therapy, especially long-term peritoneal dialysis (PD) and kidney transplantation (KTx), are rarely reported. We herein present the case of an elderly patient with TA treated by PD for more than 5 years and underwent KTx thereafter. Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-019-1302-5DOI Listing
April 2019
4 Reads

S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1.

BMC Nephrol 2019 Apr 18;20(1):135. Epub 2019 Apr 18.

Center for Experimental Medical Research, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, Hunan, 410013, People's Republic of China.

Aims: Sphingosine-1-phosphate receptor 2 (S1PR2) is a G-protein-coupled receptor that regulates sphingosine-1-phosphate-triggered cellular response. However, the role of S1PR2 in diabetes-induced glomerular endothelial cell dysfunction remains unclear. This study aims to investigate the effect of S1PR2 blockade on the morphology and function of mitochondria in human renal glomerular endothelial cells (HRGECs). Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-019-1323-0DOI Listing
April 2019
1 Read

Associations of serum and dialysate electrolytes with QT interval and prolongation in incident hemodialysis: the Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease (PACE) study.

BMC Nephrol 2019 Apr 18;20(1):133. Epub 2019 Apr 18.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Prolonged QT interval in hemodialysis patients may be associated with sudden cardiac death, however, few studies examined the longitudinal associations of modifiable factors such as serum and dialysate concentrations of calcium, potassium, and magnesium with corrected QT (QTc) prolongation in incident hemodialysis patients.

Methods: In 330 in-center hemodialysis participants from the PACE study who were followed up for one year, we examined the associations of predialysis serum electrolytes (total calcium [Ca], corrected Ca [cCa], ionized Ca [iCa], potassium [K], magnesium [Mg]), dialysate (dCa and dK), and serum-to-dialysate gradient measures with QTc interval and prolongation (≥460 ms in women and ≥ 450 ms in men).

Results: At the first study visit, 47% had QTc prolongation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1282-5DOI Listing
April 2019
1 Read

Improving proteinuria screening with mailed smartphone urinalysis testing in previously unscreened patients with hypertension: a randomized controlled trial.

BMC Nephrol 2019 Apr 18;20(1):132. Epub 2019 Apr 18.

Geisinger Health System, Department of Nephrology, 100 N Academy Ave, Danville, PA17822, USA.

Background: Proteinuria screening is recommended for patients with hypertension to screen for kidney disease and identify those at elevated risk for cardiovascular disease. However, screening rates among hypertensive patients are low. Home testing strategies may be useful in improving proteinuria screening adherence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1324-zDOI Listing

NAV-KIDS trial: protocol for a multi-centre, staggered randomised controlled trial of a patient navigator intervention in children with chronic kidney disease.

BMC Nephrol 2019 Apr 18;20(1):134. Epub 2019 Apr 18.

Centre for Kidney Research at The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Background: Chronic kidney disease (CKD) is a devastating illness associated with increased mortality, reduced quality of life, impaired growth, neurocognitive impairment and psychosocial maladjustment in children. There is growing evidence of socioeconomic disparities in health outcomes among children with CKD. Patient navigators are trained non-medical personnel who assist patients with chronic conditions journey through the continuum of care and transit across different care settings. Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-019-1325-yDOI Listing
April 2019
2 Reads

Association between prediabetes (defined by HbA1, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study.

BMC Nephrol 2019 Apr 16;20(1):130. Epub 2019 Apr 16.

Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Dongil-ro 1342, Nowon-gu, Seoul, 01757, South Korea.

Background: The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and Epidemiology Study.

Methods: This prospective cohort study included 7728 Korean adults without baseline CKD and type 2 diabetes. Prediabetes was defined by impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and HbA1 level. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1307-0DOI Listing
April 2019
1 Read

Predictors of short-term successful discontinuation of continuous renal replacement therapy: results from a prospective multicentre study.

BMC Nephrol 2019 Apr 15;20(1):129. Epub 2019 Apr 15.

Department of Intensive Care, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Background: Prediction of successful discontinuation of continuous renal replacement therapy (CRRT) might reduce complications of over- and under-treatment. The aim of this study was to identify renal and non-renal predictors of short-term successful discontinuation of CRRT in patients in whom CRRT was stopped because renal recovery was expected and who were still in the Intensive Care Unit (ICU) at day 2 after stop CRRT.

Methods: Prospective multicentre observational study in 92 patients alive after discontinuation of CRRT for acute kidney injury (AKI), still in the ICU and free from renal replacement therapy (RRT) at day 2 after discontinuation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1327-9DOI Listing
April 2019
1 Read

miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma.

BMC Nephrol 2019 Apr 11;20(1):127. Epub 2019 Apr 11.

Department of Urology, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, 410000, Hunan Province, People's Republic of China.

Background: MicroRNAs have been related to tumor progression in diverse human cancers including clear-cell renal cell carcinoma (ccRCC). Previous study has suggested the important regulation function of miR-10b in ccRCC. However, the direct target of miR-10b in ccRCC and the related molecular mechanisms has not yet been revealed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1322-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458703PMC
April 2019
1 Read

Dialysate cell-free mitochondrial DNA fragments as a marker of intraperitoneal inflammation and peritoneal solute transport rate in peritoneal dialysis.

BMC Nephrol 2019 Apr 11;20(1):128. Epub 2019 Apr 11.

The Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Rd, Hangzhou, Zhejiang, 310003, People's Republic of China.

Background: Mitochondrial DNA (mtDNA) released into extracellular subsequent to cell injury and death can promote inflammation in patients and animal models. However, the effects of peritoneal dialysate cell-free mtDNA on intraperitoneal inflammation and peritoneal solute transport rate (PSTR) in peritoneal dialysis (PD) patients remain unclear.

Methods: We select the incident patients who began PD therapy between January 1, 2009, and December 30, 2010. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1284-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458606PMC

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature.

BMC Nephrol 2019 Apr 11;20(1):126. Epub 2019 Apr 11.

Molecular Biology Laboratory, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona, REDinREN, Instituto de Investigación Carlos III, Cartagena 340-350, 08025, Barcelona, Catalonia, Spain.

Background: Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disorder characterized by early-onset nephrotic syndrome and microcephaly with brain anomalies. WDR73 pathogenic variants were described as the first genetic cause of GAMOS and, very recently, four novel causative genes, OSGEP, LAGE3, TP53RK, and TPRKB, have been identified.

Case Presentation: We present the clinical and genetic characteristics of two unrelated infants with clinical suspicion of GAMOS who were born from consanguineous parents. Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-019-1317-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458604PMC
April 2019
2 Reads

Outcomes in patients with atypical hemolytic uremic syndrome treated with eculizumab in a long-term observational study.

BMC Nephrol 2019 Apr 10;20(1):125. Epub 2019 Apr 10.

Division of Pediatric Nephrology, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive NE, Atlanta, GA, 30322, USA.

Background: There are limited long-term outcome data in eculizumab-treated patients with atypical hemolytic uremic syndrome (aHUS). We report final results from the largest prospective, observational, multicenter study of patients with aHUS treated with eculizumab.

Methods: Patients with aHUS who participated in any of five parent eculizumab trials and received at least one eculizumab infusion were eligible for enrollment in a long-term follow-up study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456946PMC
April 2019
1 Read

Quality of life among patients with moderate to advanced chronic kidney disease in Ghana - a single centre study.

BMC Nephrol 2019 Apr 8;20(1):122. Epub 2019 Apr 8.

Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, School of Medical Sciences, Kumasi, Ghana.

Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal disease (ESRD). There is growing interest worldwide in QOL of CKD patients but paucity of data in Ghana. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454740PMC
April 2019
1 Read

IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney.

BMC Nephrol 2019 Apr 8;20(1):124. Epub 2019 Apr 8.

Department of Physiology, Pomeranian Medical University in Szczecin, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.

Background: Interleukin 17 is a proinflammatory cytokine involved in immune response after allograft transplantation. IL-17 family of proinflammatory cytokines includes IL-17A and IL-17F. Previous studies have demonstrated that the rs2275913 IL17A and the rs11465553 IL17F gene polymorphism are associated with kidney allograft function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1308-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454731PMC
April 2019
1 Read

Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature.

BMC Nephrol 2019 Apr 8;20(1):123. Epub 2019 Apr 8.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuo, Ami, Ibaraki, 300-0395, Japan.

Background: Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and membranous nephropathy are frequently observed in glomerular lesions of thymoma patients, but ANCA-associated renal vasculitis is rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1319-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454690PMC
April 2019
1 Read

Impact of salt taste dysfunction on interdialytic weight gain for hemodialysis patients; a cross-sectional study.

BMC Nephrol 2019 Apr 5;20(1):121. Epub 2019 Apr 5.

Department of Nephrology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: Little is known about salt taste dysfunction among hemodialysis (HD) patients. This study aimed to elucidate the prevalence of salt taste dysfunction and its relationship with interdialytic weight gain (IDWG) among HD patients.

Methods: A single-center cross-sectional study involving 99 maintenance HD patients was conducted in September 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1312-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451217PMC

Serum klotho is inversely associated with metabolic syndrome in chronic kidney disease: results from the KNOW-CKD study.

BMC Nephrol 2019 Apr 3;20(1):119. Epub 2019 Apr 3.

Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Korea.

Background: Metabolic syndrome (MS) is prevalent in chronic kidney disease (CKD). Klotho, a protein linked to aging, is closely associated with CKD. Each component of MS and klotho has an association. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1297-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446407PMC
April 2019
1 Read

Urinary angiostatin: a novel biomarker of kidney disease associated with disease severity and progression.

BMC Nephrol 2019 Apr 3;20(1):118. Epub 2019 Apr 3.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, 100853, China.

Background: This study aimed to evaluate the value of urinary angiostatin levels for assessing disease severity and progression of IgA nephropathy (IgAN).

Methods: Urinary angiostatin was identified as one of the distinct proteins in samples of patients with IgAN analyzed by Raybiotech protein array, and further confirmed by enzyme-linked immunosorbent assay (ELISA).

Results: Urinary angiostatin levels were significantly higher in IgAN patients than that in healthy controls (HC) subjects and lower than in disease controls (DC) patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1305-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446319PMC
April 2019
2 Reads
1.520 Impact Factor

Small intestinal perforation due to a huge gastrointestinal stromal tumor in a kidney transplant recipient: a case report and literature review.

BMC Nephrol 2019 Apr 3;20(1):120. Epub 2019 Apr 3.

Department of Urology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Background: Gastrointestinal stromal tumors (GISTs) in transplant recipients are very rare and only a handful of cases have been reported to date. Here we present the first known case of a huge GIST in a kidney transplant recipient with perforation of small intestine.

Case Presentation: A 64-year-old male presented at our hospital with right colic pain; he had received an ABO incompatible kidney transplant 6 years earlier and was treated with cyclosporine, mycophenolate mofetil, and methylprednisolone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1310-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448240PMC
April 2019
3 Reads
1.520 Impact Factor

A need-based approach to self-management education for adults with co-morbid diabetes and chronic kidney disease.

BMC Nephrol 2019 Apr 2;20(1):113. Epub 2019 Apr 2.

School of Public Health and Preventive Medicine, Monash University, Alfred Centre, 99 Commercial Road, Melbourne, 3004, Australia.

Background: Self-management education needs have not been assessed in patients with complex co-morbid conditions such as diabetes and chronic kidney disease (CKD). The objectives of this study were to 1) determine the self-management education needs for patients with co-morbid diabetes and CKD and 2) co-develop an educational resource meeting the self-management education needs of patients with co-morbid diabetes and CKD.

Methods: Patients with co-morbid diabetes and CKD attending a co-designed, patient-centred outpatient diabetes and kidney clinic at a tertiary metropolitan hospital were recruited for semi-structured interviews. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1296-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444589PMC
April 2019
1.520 Impact Factor

Phenprocoumon based anticoagulation is an underestimated factor in the pathogenesis of calciphylaxis.

BMC Nephrol 2019 Apr 2;20(1):114. Epub 2019 Apr 2.

Department of Nephrology, University Hospital of Marburg, UKGM GmbH, Baldingerstraße 1, 35033, Marburg, Germany.

Background: Calciphylaxis is a life threatening complication in renal patients. Of great importance is the identification of concomitant factors for calciphylaxis. Due to the variability of clinical presentation the evaluation of such factors may be obscured when calciphylaxis diagnosis is based just on clinical features. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1301-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444830PMC
April 2019
4 Reads

Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study.

BMC Nephrol 2019 Apr 2;20(1):117. Epub 2019 Apr 2.

Cohort Study Team, Center for Cluster Development and Coordination, Foundation for Biomedical Research and Innovation at Kobe, 2-2 Minatojima Minamimachi, Chuo-ku, Hyogo, 650-0047, Japan.

Background: Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate (eGFR). We aimed to clarify the relationship between SUA levels and kidney function assessed by cystatin C in a Japanese general community population without chronic kidney disease (CKD).

Methods: We conducted a community-based cross-sectional study that included 1086 healthy participants, aged 40-74 years, without CKD and not undergoing treatment of hyperuricemia, who had participated in the baseline survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1291-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446294PMC
April 2019
2 Reads

Patient-reported advantages and disadvantages of peritoneal dialysis: results from the PDOPPS.

BMC Nephrol 2019 Apr 2;20(1):116. Epub 2019 Apr 2.

St. Michael's Hospital, Toronto, ON, Canada.

Background: Patient-reported measures are increasingly recognized as important predictors of clinical outcomes in peritoneal dialysis (PD). We sought to understand associations between patient-reported perceptions of the advantages and disadvantages of PD and clinical outcomes.

Methods: In this cohort study, 2760 PD patients in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) completed a questionnaire on their PD experience, between 2014 and 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1304-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446371PMC
April 2019
1 Read

Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease: a prospective observational study.

BMC Nephrol 2019 Apr 2;20(1):115. Epub 2019 Apr 2.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Blood urea nitrogen (BUN) is one of the substances that affects the calculated serum osmolality (cSosm). A previous study demonstrated that BUN and cSosm were independently associated with the development of chronic kidney disease (CKD) in patients with preserved kidney function. In advanced CKD stages, there is a concomitant increase in cSosm and BUN levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1306-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444850PMC
April 2019
1 Read

Use of the KDQOL-36™ for assessment of health-related quality of life among dialysis patients in the United States.

BMC Nephrol 2019 Apr 1;20(1):112. Epub 2019 Apr 1.

DaVita Clinical Research, 825 S 8th St, Minneapolis, MN, 55404, USA.

Background: Health-related quality of life (HRQOL) is a key outcome for dialysis patients, and its assessment is mandated by the Centers for Medicaid and Medicare Services. The Kidney Disease Quality of Life (KDQOL-36™) survey is widely used for this assessment. KDQOL-36™ completion rates, and the distributions of scores and item responses, have not been examined in a large, nationally representative cohort of dialysis patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1295-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444438PMC

Natalia Tomilina - personality and profession.

Authors:
Elena Zakharova

BMC Nephrol 2019 Apr 1;20(1):111. Epub 2019 Apr 1.

Nephrology, Moscow City Hospital n.a. S.P. Botkin, Moscow, Russian Federation.

Natalina Tomilina, a pioneer of Russian nephrology, is a clinician, researcher, teacher, organizer, leader, and a real pioneer, who has worked in nephrology from the very beginning of its development in Russia and continues to inspire new generations of Russian nephrologists. Her interests are very broad: from the physiology and pathophysiology of water and electrolyte balance and tubular dysfunctions to the management of transplant rejection, and from nephropathology to the treatment of idiopathic glomerulonephritis and ANCA-associated vasculitis…. to name a few. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1303-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442427PMC

Increased cancer risk in patients undergoing dialysis: a population-based cohort study in North-Eastern Italy.

BMC Nephrol 2019 Mar 28;20(1):107. Epub 2019 Mar 28.

Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, 33081, Aviano, (PN), Italy.

Background: In southern Europe, the risk of cancer in patients with end-stage kidney disease receiving dialysis has not been well quantified. The aim of this study was to assess the overall pattern of risk for de novo malignancies (DNMs) among dialysis patients in the Friuli Venezia Giulia region, north-eastern Italy.

Methods: A population-based cohort study among 3407 dialysis patients was conducted through a record linkage between local healthcare databases and the cancer registry (1998-2013). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1283-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437907PMC
March 2019
1 Read

Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients.

BMC Nephrol 2019 Mar 29;20(1):109. Epub 2019 Mar 29.

Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center+, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.

Background: Prospective studies combining physical functioning (PF), physical activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these parameters between kidney transplant recipients and their living donors by examining changes in these parameters in the first post-operative year in both groups.

Methods: Twenty-two kidney transplant recipients and 22 healthy kidney donors were included in this prospective longitudinal study with a follow-up until twelve months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1299-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440145PMC

Impact of diabetes on sarcopenia and mortality in patients undergoing hemodialysis.

BMC Nephrol 2019 Mar 28;20(1):105. Epub 2019 Mar 28.

Department of Nephrology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Sarcopenia has become a serious disorder in modern society. Chronic kidney disease requiring dialysis and diabetes are some of the disorders that accelerate the onset and progression of sarcopenia. We, therefore, investigated the prevalence of sarcopenia in patients undergoing hemodialysis (HD) and confirmed the impact of diabetes mellitus (DM) on this population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1271-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437886PMC

The role of podocyte damage in the etiology of ischemia-reperfusion acute kidney injury and post-injury fibrosis.

BMC Nephrol 2019 Mar 28;20(1):106. Epub 2019 Mar 28.

Department of Nephrology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.

Background: To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims included using the model to explore the role of podocyte injury in AKI and post-injury fibrosis.

Methods: Fifty BALB/C mice were randomly divided into control group (Ctr), sham group (sham), AKI 20 group (renal ischemia, 20 min reperfusion), AKI 30 group (renal ischemia, 30 min reperfusion) and AKI 40 group (renal ischemia, 40 min reperfusion). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1298-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438002PMC
March 2019
1 Read

Patient and provider experience and perspectives of a risk-based approach to multidisciplinary chronic kidney disease care: a mixed methods study.

BMC Nephrol 2019 Mar 29;20(1):110. Epub 2019 Mar 29.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: The Kidney Failure Risk Equation (KFRE) predicts risk of progression to kidney failure and is used to guide clinical decisions for patients with chronic kidney disease (CKD).

Methods: The KFRE was implemented to guide access to multidisciplinary care for CKD patients in Alberta, Canada, based on their 2-year risk of kidney failure. We used a mixed methods approach to investigate patients' and providers' perspectives and experiences 1 year following KFRE implementation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1269-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440153PMC
March 2019
2 Reads

Quality of life after the initiation of dialysis or maximal conservative management in elderly patients: a longitudinal analysis of the Geriatric assessment in OLder patients starting Dialysis (GOLD) study.

BMC Nephrol 2019 Mar 29;20(1):108. Epub 2019 Mar 29.

Department of Geriatrics, Diakonessenhuis Utrecht, Utrecht, The Netherlands.

Background: Maximal conservative management (MCM) may be an appropriate alternative option for dialysis in some elderly patients with end-stage kidney disease (ESKD). Evidence about the impact of dialysis or MCM on quality of life (QoL) in older patients is sparse. In the GOLD (Geriatric assessment in OLder patients starting Dialysis) Study the trajectory of QoL was assessed in patients starting dialysis or MCM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1268-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440027PMC
March 2019
1 Read

Sleep disturbance among Malaysian patients with end-stage renal disease with pruritus.

BMC Nephrol 2019 Mar 25;20(1):102. Epub 2019 Mar 25.

School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia.

Background: Chronic kidney disease-associated pruritus (CKD-aP) is a well-recognized, frequent and compromising complication among patients on hemodialysis. Despite advancement in basic medical sciences, CKD-aP is still a major complication and a challenge for both physicians and patients to manage. The aim of this study was to estimate the prevalence of CKD-aP among hemodialysis patients in Malaysia, to determine the impact of CKD-aP on sleep quality and any factors associated with CKD-aP. Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-019-1294-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434782PMC
March 2019
5 Reads
1.520 Impact Factor

Urinary angiotensinogen level is associated with potassium homeostasis and clinical outcome in patients with polycystic kidney disease: a prospective cohort study.

BMC Nephrol 2019 Mar 25;20(1):104. Epub 2019 Mar 25.

Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, 03722, Republic of Korea.

Background: Guidelines for general hypertension treatment do not recommend the combined use of renin-angiotensin-aldosterone system (RAAS) inhibitors due to the risk of hyperkalemia. However, a recent clinical trial showed that polycystic kidney disease (PKD) patients had infrequent episodes of hyperkalemia despite receiving combined RAAS inhibitors. Because intrarenal RAAS is a main component for renal potassium handling, we further investigated the association between intrarenal RAAS activity and serum potassium level in patients with chronic kidney disease, particularly in PKD patients, and examined whether intrarenal RAAS activity has a prognostic role in patients with PKD. Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-019-1292-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434770PMC
March 2019
5 Reads

Statin use and the risk of acute kidney injury in older adults.

BMC Nephrol 2019 Mar 25;20(1):103. Epub 2019 Mar 25.

Department of Medicine, University of Calgary, 7th Floor, TRW Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.

Background: As more patients at lower cardiovascular (CV) risk are treated with statins, the balance between cardiovascular benefits and the risk of adverse events becomes increasingly important.

Methods: We did a population-based cohort study (May 1, 2002 to March 30, 2013) using province-wide laboratory and administrative data in Alberta. We studied new statin users aged 66 years of age and older who were not receiving renal replacement therapy at baseline. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1280-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434639PMC
March 2019
1 Read

Induction therapy with thymoglobulin or interleukin-2 receptor antagonist for Chinese recipients of living donor renal transplantation: a retrospective study.

BMC Nephrol 2019 Mar 22;20(1):101. Epub 2019 Mar 22.

Division of Organ Transplantation, the First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan II Road, Guangzhou, 510080, China.

Background: Recipients of living donor renal transplantation are typically considered to have a relatively lower immunological risk. This retrospective study aimed to compare the therapeutic efficacy and safety between rabbit antithymocyte globulin (rATG) or interleukin-2 receptor antagonist (IL2-RA) induction therapies in Chinese population.

Methods: A total of 188 patients receiving living donor renal transplantation between February 2004 and December 2013 were included and divided into the rATG group and based on their induction therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1293-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429807PMC
March 2019
1.520 Impact Factor

Mapping the UK renal psychosocial workforce: the first comprehensive workforce survey.

BMC Nephrol 2019 Mar 21;20(1):100. Epub 2019 Mar 21.

Renal Unit, City Hospital Campus, Nottingham University Hospitals NHS Trust Hucknall, Road Nottingham, Nottingham, NG5 1PB, UK.

Background: Emerging evidence of psychosocial problems in CKD patients has led to an acceptance that a focus on the emotional wellbeing of the patient should be included in the provision of comprehensive CKD care. It is unclear if an increased attention for psychosocial needs in guidelines and policy documents has led to a rise in psychosocial staffing levels or change in composition of staff since the last workforce mapping in 2002. This paper offers a critical analysis and in-depth discussion of findings and their implications, in addition to providing an international perspective and exposing gaps in current knowledge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1287-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427898PMC
March 2019
2 Reads

Design and methodology of the impact of HemoDiaFIlTration on physical activity and self-reported outcomes: a randomized controlled trial (HDFIT trial) in Brazil.

BMC Nephrol 2019 Mar 20;20(1):98. Epub 2019 Mar 20.

Universidade Federal de São Paulo, R. Sena Madureira 1500, São Paulo, São Paulo, 04021-001, Brazil.

Background: End stage renal disease (ESRD) patients require a renal replacement therapy (RRT) to filter accumulated toxins and remove excess water, which are associated with impaired physical function. Hemodialysis (HD) removes middle-molecular weight (MMW) toxins less efficiently compared to hemodiafiltration (HDF); we hypothesized HDF may improve physical function. We detailed the design and methodology of the HDFIT protocol that is testing whether changing from HD to HDF effects physical activity levels and various outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1247-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425582PMC

Spectrum of acute kidney injury associated with cocaine use: report of three cases.

BMC Nephrol 2019 Mar 20;20(1):99. Epub 2019 Mar 20.

Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Estadual University of Ceará, Fortaleza, Brazil.

Background: The consequences of cocaine use are multisystemic, such as, for instance, renal failure, hepatotoxicity and pulmonary toxicity, with renal alterations being the focus of the present study. The use of substances that modify the base composition of cocaine (or adulterants) aiming to potentiate its effects also has an impact on these manifestations. The present study aims to report three cases with different diagnosis of acute kidney injury related to cocaine use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1279-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427899PMC
March 2019
3 Reads

The pioneers of nephrology - Professor Natalia Tomilina: courage, passion and humanism in medicine.

BMC Nephrol 2019 Mar 19;20(1):97. Epub 2019 Mar 19.

BioMed Central, The Campus, 4 Crinan St, London, N1 9XW, UK.

Listening to the interview of Natalia Tomilina is an inspiring experience, and not one reserved purely for young physicians. Within these pages, one can discover Tomilina's determination and passion for learning that has been with her throughout her life, even during difficult and testing times. A great resolve that she developed through the teachings of her parents and her mentor, Prof. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1252-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425577PMC

"Exercise during hemodialysis and health promoting behaviors: a clinical trial".

BMC Nephrol 2019 Mar 19;20(1):96. Epub 2019 Mar 19.

MS of Critical Care Nursing, Amin Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Health promoting behaviors are among the determinants of health. Hemodialysis causes significant changes in the lives of patients and affects their health promoting behaviors. Accordingly, this study aimed at investigating the effect of exercise during hemodialysis on health promotion behaviors in patients undergoing hemodialysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1276-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425622PMC
March 2019
1 Read
1.520 Impact Factor

Hyperuricemia and its related histopathological features on renal biopsy.

BMC Nephrol 2019 Mar 18;20(1):95. Epub 2019 Mar 18.

Renal Department and Nephrology Institute, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Background: Hyperuricemia (HUA) is very common in chronic kidney disease (CKD). HUA is associated with an increased risk of cardiovascular events and accelerates the progression of CKD. Our study aimed to explore the relationship between baseline serum uric acid levels and renal histopathological features. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1275-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423852PMC
March 2019
2 Reads
1.520 Impact Factor

Shearing-force injury of a kidney transplant graft during cesarean section: a case report and review of the literature.

BMC Nephrol 2019 Mar 18;20(1):94. Epub 2019 Mar 18.

Department of Obstetrics & Gynecology, University of California, Irvine, 333 City Blvd, West - Suite 1400, Orange, CA, 92868, USA.

Background: With an increasing number of reproductive-aged women undergoing renal transplantation coupled with improved fertility post-transplantation, more women are becoming pregnant with a kidney transplant in place. This leads to increased risk of perinatal complications such as pre-eclampsia, gestational diabetes, preterm delivery and Cesarean section. Given that kidney transplants are often placed extra-peritoneally in the iliac fossa, there is also a risk of damage to the transplanted kidney at the time of Cesarean section. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1281-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423748PMC
March 2019
1 Read

Gout is associated with a higher risk of chronic renal disease in older adults: a retrospective cohort study of U.S. Medicare population.

BMC Nephrol 2019 Mar 15;20(1):93. Epub 2019 Mar 15.

Department of Medicine at School of Medicine, University of Alabama at Birmingham, 1720 Second Ave. South, Birmingham, AL, 35294-0022, USA.

Background: Hyperuricemia and gout have been linked to chronic kidney disease (CKD). Whether the increased risk of CKD in gout is due to shared risk factors such as hypertension, diabetes or heart disease, or due to gout itself is not known. Studies in older adults, who tend to have a high incidence of CKD, are limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1274-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420755PMC

Assessment of nutritional status in the maintenance of haemodialysis patients: a cross-sectional study from Palestine.

BMC Nephrol 2019 Mar 15;20(1):92. Epub 2019 Mar 15.

Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.

Background: Protein-energy wasting (PEW) is a relatively prevalent problem among adult haemodialysis patients (HDP). PEW is an important determinant of morbidity and mortality in HDP, therefore it is essential for dietitians to accurately assess malnutrition (MN) in these patients. HDP appear to be more susceptible to developing MN; however, this is not well documented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1288-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420767PMC
March 2019
1 Read
1.520 Impact Factor

The conundrum of postpartum thrombotic Microangiopathy: case report and considerations for management.

BMC Nephrol 2019 Mar 14;20(1):91. Epub 2019 Mar 14.

Department of Internal Medicine, Intensive Care Unit, Medical University Graz, Auenbruggerplatz 15, A-8036, Graz, Austria.

Background: Microangiopathic hemolytic anemias and thrombocytopenias in pregnant or postpartum women constitute an interdisciplinary diagnostic and therapeutic challenge in the evaluation of thrombotic microangiopathies (TMA), where urgent care must be considered.

Case Presentation: We here report the case of a 21-year-old Somali woman, who was delivered by emergency caesarean section at 35 weeks of gestational age with acute dyspnea, placental abruption and gross edema due to severe preeclampsia/HELLP syndrome. After delivery, she developed acute kidney failure and thrombotic microangiopathy as revealed by kidney biopsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1286-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417121PMC
March 2019
1 Read

Efficacy, tolerability and safety of darbepoetin alfa injection for the treatment of anemia associated with chronic kidney disease (CKD) undergoing dialysis: a randomized, phase-III trial.

BMC Nephrol 2019 Mar 13;20(1):90. Epub 2019 Mar 13.

Ashwini Hospital and Ramakanth Heart Care Center, Shivaji Nagar, Nanded, Maharashtra, India.

Background: Darbepoetin alfa (DA-α) is a long-acting erythropoiesis-stimulating glycoprotein which has half-life three-fold longer than that of Erythropoietin alfa (EPO). The objective of this study was to compare the efficacy and safety of DA-α injection versus EPO for treating renal anemia amongst Indian patients with end-stage renal disease (ESRD) undergoing dialysis.

Methods: Patients of either gender (aged 18-65 years) with ESRD undergoing dialysis who had hemoglobin (Hb) levels < 10 g/dL after receiving EPO were switched to DA-α (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1209-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417108PMC
March 2019
1 Read

Effect of steroids and relevant cytokine analysis in acute tubulointerstitial nephritis.

BMC Nephrol 2019 Mar 12;20(1):88. Epub 2019 Mar 12.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Background: Acute tubulointerstitial nephritis (ATIN) is an important cause of acute kidney injury and often a potentially reversible disease. However, the role of steroids in ATIN remains controversial and the underlying mechanisms remain unresolved.

Methods: A total of 113 adult patients with biopsy-proven ATIN were recruited from three tertiary referral centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1277-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417076PMC
March 2019
1 Read

Short-term outcome associated with disease severity and electrolyte abnormalities among critically ill children with acute kidney injury.

BMC Nephrol 2019 Mar 12;20(1):89. Epub 2019 Mar 12.

Pediatric Nephrology Center of Excellence, Pediatric Department, Faculty of Medicine, King Abdulaziz University, PO Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.

Background: Acute kidney injury (AKI) in critically ill children is associated with increased mortality and morbidity. In this study we evaluated the effect of AKI severity on the incidence of short-term mortality and morbidity.

Methods: Multicenter prospective cohort study was conducted over two years period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1278-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417256PMC
March 2019
1.520 Impact Factor

Dasatinib-induced nephrotic syndrome in a patient with chronic myelogenous leukemia: a case report.

BMC Nephrol 2019 Mar 7;20(1):87. Epub 2019 Mar 7.

Dialysis Division, University of Miyazaki Hospital, Miyazaki, Japan.

Background: Dasatinib is a second-generation tyrosine kinase inhibitor that is indicated for the treatment of patients with chronic myeloid leukemia. Here, we report the case of a man with nephrotic syndrome that was caused by dasatinib.

Case Presentation: A 40-year-old man with chronic myeloid leukemia was referred to our hospital because of proteinuria 1 month after dasatinib therapy was introduced. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1273-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407224PMC
March 2019
1 Read