2,071 results match your criteria BMC Nephrology[Journal]


Analysis of the differential urinary protein profile in IgA nephropathy patients of Uygur ethnicity.

BMC Nephrol 2018 Dec 14;19(1):358. Epub 2018 Dec 14.

Nephrology department, The Xinjiang Uygur Autonomous Region People's Hospital, 91 Tianchi Road, Urumqi, Xinjiang, China.

Background: IgA nephropathy (IgAN) is one of the most common forms of idiopathic glomerular diseases and might lead to end-stage kidney disease. Accurate and non-invasive biomarkers for early diagnosis are required for early intervention and consequent therapy for IgAN patients. Because variance in the disease incidence and predisposing genes of IgAN has been detected among different ethnicities, the ethnicity factor should be considered in IgAN biomarker discovery. Read More

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http://dx.doi.org/10.1186/s12882-018-1139-3DOI Listing
December 2018

Analysis of predictive factors for immunosuppressive response in anti-phospholipase A2 receptor antibody positive membranous nephropathy.

BMC Nephrol 2018 Dec 12;19(1):354. Epub 2018 Dec 12.

Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyan, Wangfujing St, Beijing, 100730, China.

Background: Serum anti-phospholipase A2 receptor (PLA2R) antibody was correlated with disease activity of membranous nephropathy(MN). The predictive value of antibody titer changes on immunosuppressive response remains unknown. We investigated predictive value of dynamic change of anti-PLA2R antibody and 24-h urine protein (24hUP) for clinical response of MN. Read More

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http://dx.doi.org/10.1186/s12882-018-1160-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292075PMC
December 2018

A rare case of Alport syndrome, atypical hemolytic uremic syndrome and Pauci-immune crescentic glomerulonephritis.

BMC Nephrol 2018 Dec 12;19(1):355. Epub 2018 Dec 12.

Department of Pathology, Stanford University, Stanford, CA, USA.

Background: Renal thrombotic microangiopathy (TMA) is occasionally seen in biopsies with pauci-immune necrotizing crescentic glomerulonephritis (PCGN). Recent study indicated that the complement activation is more prominent in the ANCA-negative glomerulonephritis.

Case Presentation: We report a case of concurrent TMA and PCGN without ANCA positivity. Read More

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http://dx.doi.org/10.1186/s12882-018-1170-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291978PMC
December 2018

Effect of ultrafiltration during hemodialysis on hepatic and total-body water: an observational study.

BMC Nephrol 2018 Dec 12;19(1):356. Epub 2018 Dec 12.

The Lilibeth Caberto Kidney Clinical Research Unit, Victoria Hospital, Western University, A2-344, 800 Commissioners Road East, London, ON, N6A 5W9, Canada.

Background: The hepatic circulation is involved in adaptive systemic responses to circulatory stress. However, it is vulnerable to both chronic hypervolemia and cardiac dysfunction. The influence of hemodialysis (HD) and ultrafiltration (UF) upon liver water content has been understudied. Read More

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http://dx.doi.org/10.1186/s12882-018-1150-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292051PMC
December 2018

The elevated levels of urinary angiotensinogen are correlated with the severity of idiopathic membranous nephropathy.

BMC Nephrol 2018 Dec 12;19(1):357. Epub 2018 Dec 12.

Department of Nephrology, Peking University Third Hospital, No. 49, North Garden Road, Haidian District, Beijing, 100191, China.

Background: Immunosuppressive treatment will predispose an idiopathic membranous nephropathy (iMN) patient to opportunistic infections. Disease severity is one of the main concerns for making the treatment decision. Urinary angiotensinogen (UAGT) level has been shown highly correlated with intrarenal renin-angiotensin system (RAS) activity and severity of chronic kidney diseases (CKD). Read More

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http://dx.doi.org/10.1186/s12882-018-1165-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291953PMC
December 2018

Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study.

BMC Nephrol 2018 Dec 11;19(1):351. Epub 2018 Dec 11.

University of the State of Rio de Janeiro, Rio de Janeiro, Brasil.

Background: Contrast enhanced ultrasonography (CEUS) assessment of kidney allografts mainly focuses on graft rejection. However, studies on delayed graft function (DGF) without acute rejection are still lacking. The aim of this study was to build a time-intensity curve (TIC) using CEUS in non-immunological DGF to understand the utility of CEUS in early transplantation. Read More

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http://dx.doi.org/10.1186/s12882-018-1158-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288962PMC
December 2018
1 Read

Hepatitis B virus infection and development of chronic kidney disease: a cohort study.

BMC Nephrol 2018 Dec 11;19(1):353. Epub 2018 Dec 11.

Departments of Epidemiology and Medicine, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

Background: The effect of chronic hepatitis B virus (HBV) infection on the risk of chronic kidney disease (CKD) is controversial. We examined the prospective association between hepatitis B surface antigen (HBsAg) serology status and incident CKD in a large cohort of men and women.

Methods: Cohort study of 299,913 adults free of CKD at baseline who underwent health screening exams between January 2002 and December 2016 in South Korea. Read More

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http://dx.doi.org/10.1186/s12882-018-1154-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288894PMC
December 2018
1 Read

Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report.

BMC Nephrol 2018 Dec 11;19(1):352. Epub 2018 Dec 11.

Intern Doctor, Internal Medicine Department, An-Najah National University Hospital, Nablus, Palestine.

Background: Baclofen is a centrally acting GABA receptor agonist and it is used widely for the treatment of spasticity, persistent hiccups and multiple sclerosis. The renal system is the main route of excretion, thus people with suboptimal renal function are prone to baclofen intoxication. Multiple doses of baclofen have been associated with toxicity, but it is very unusual that single dose can do so. Read More

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http://dx.doi.org/10.1186/s12882-018-1167-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288861PMC
December 2018
1 Read

Maternally inherited diabetes and deafness complicated by mesangial galactose-deficient IgA1 deposits: a case report.

BMC Nephrol 2018 Dec 10;19(1):350. Epub 2018 Dec 10.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Background: Maternally inherited diabetes and deafness (MIDD), a mitochondrial genetic disorder, typically affects the kidneys and results in end-stage renal disease. Early diagnosis of MIDD is challenging when renal manifestations precede other key clinical features such as diabetes and deafness and/or when the disease is complicated by other renal pathologies.

Case Presentation: Here, we present the case of a 33-year-old Japanese woman who had initially been diagnosed with IgA nephropathy but was found to have MIDD 6 years later. Read More

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http://dx.doi.org/10.1186/s12882-018-1152-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288957PMC
December 2018

Early onset of graft glomerulopathy in a patient with post-transplant diabetes mellitus after renal transplantation: a case report.

BMC Nephrol 2018 Dec 7;19(1):348. Epub 2018 Dec 7.

Nephrology, Dialysis and Renal Transplant Unit, IRCCS Policlinico San Matteo Foundation, P.le Golgi 19, 27100, Pavia, Italy.

Background: Post-transplant diabetes mellitus (PTDM) is an emerging problem in kidney transplantation, representing an important risk factor for kidney function loss. Diabetic nephropathy (DN) occurrence in transplanted kidneys is poorly investigated. Current knowledge describes DN recurrence in graft 5. Read More

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http://dx.doi.org/10.1186/s12882-018-1141-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286527PMC
December 2018

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes.

BMC Nephrol 2018 Dec 4;19(1):347. Epub 2018 Dec 4.

Department of Medical Sciences, Scientific Institute "Casa Sollievo della Sofferenza", IRCCS Casa Sollievo della Sofferenza, v.le Cappuccini, 71013, San Giovanni Rotondo, FG, Italy.

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage ≥3 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage ≥3 CKD in a large cohort of patients affected by T1DM. Read More

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http://dx.doi.org/10.1186/s12882-018-1136-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280443PMC
December 2018
2 Reads

Short-term dexamethasone treatment transiently, but not permanently, attenuates fibrosis after acute-to-chronic kidney injury.

BMC Nephrol 2018 Dec 3;19(1):343. Epub 2018 Dec 3.

Laboratory of Pathophysiology, University of Antwerp, 2160, Antwerpen, Belgium.

Background: Acute kidney injury (AKI) is an underestimated, yet important, risk factor for the development of chronic kidney disease (CKD). Persistence of inflammation after a renal ischemic injury has been observed, both in experimental models and patients, and is thought to be an important mechanisms underlying progression of acute-to-chronic renal injury. Temporary suppression of inflammation immediately after AKI might therefore be a good first-line therapeutic strategy towards a better long term outcome. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1151-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276259PMC
December 2018
2 Reads

Recurrent glomerulonephritis following renal transplantation and impact on graft survival.

BMC Nephrol 2018 Dec 3;19(1):344. Epub 2018 Dec 3.

Department of Renal Medicine, The Canberra Hospital, PO Box 11, Woden, Canberra, ACT 2605, Australia.

Background: Recurrence of primary glomerulonephritis in the post-transplant period has been described in the literature but the risk remains poorly quantified and its impact on allograft outcomes and implications for subsequent transplants remain under-examined. Here we describe the rates and timing of post-transplant glomerulonephritis recurrence for IgA nephropathy, focal segmental glomerulosclerosis, mesangiocapillary GN and membranous GN based on 28 years of ANZDATA registry transplant data.

Methods: We investigated the rates of GN recurrence and subsequent graft outcomes in 7236 patient from 28 years of ANZDATA transplant registry data. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1135-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278033PMC
December 2018
5 Reads

A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.

BMC Nephrol 2018 Dec 4;19(1):346. Epub 2018 Dec 4.

Diabetic Kidney Disease Centre, Renal Unit, Barts Health NHS Trust, The Royal London Hospital, Whitechapel Road, London, E1 1BB, UK.

Background: The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research improved therapeutic strategies to combat renal cardiac pathologies. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1155-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278034PMC
December 2018
7 Reads

Non-medical facilitators and barriers towards accessing haemodialysis services: an exploration of ethical challenges.

BMC Nephrol 2018 Dec 3;19(1):342. Epub 2018 Dec 3.

Department of Development Studies, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Background: Like most of the sub-Saharan countries, Tanzania faces significant increase in the number of patients diagnosed with an end-stage renal disease (ESRD) among which only a few manage to receive chronic haemodialysis services (CHD). Yet little is known about the non-medical facilitators and barriers towards accessing these services and the associated ethical challenges.

Methods: A phenomenological study design which employed a qualitative approach was used. Read More

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http://dx.doi.org/10.1186/s12882-018-1140-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276249PMC
December 2018

Impaired glomerular filtration rate, high grade albuminuria and associated factors among adult patients admitted to tertiary Hospital in Ethiopia.

BMC Nephrol 2018 Dec 4;19(1):345. Epub 2018 Dec 4.

Department of Internal medicine, Institute of Health, Jimma University, Jimma, Ethiopia.

Background: Chronic Kidney Disease (CKD), the worldwide Public Health problem, is also one of the rising non-communicable diseases in low and middle-income countries. Its early detection and treatment using readily available, inexpensive therapies can slow or prevent progression to end-stage renal disease. Hence, this study was aimed at assessing impaired estimated glomerular filtration rate (eGFR), high grade albuminuria, and associated factors among adult patients admitted to Jimma University Medical Center in South west Ethiopia. Read More

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http://dx.doi.org/10.1186/s12882-018-1153-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278145PMC
December 2018
1.520 Impact Factor

Peritoneal dialysis-associated infection caused by Mycobacterium abscessus: a case report.

BMC Nephrol 2018 Nov 29;19(1):341. Epub 2018 Nov 29.

Division of Nephrology, Shimane University Hospital, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan.

Background: Peritoneal dialysis (PD)-associated infection caused by Mycobacterium spp. is rare. Mycobacterium abscessus is one of the most resistant acid-fast bacteria, and treatment is also the most difficult and refractory. Read More

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http://dx.doi.org/10.1186/s12882-018-1148-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267060PMC
November 2018
4 Reads

Hemodialysis patient characteristics associated with better experience as measured by the In-center Hemodialysis Consumer Assessment of Healthcare Providers and Systems (ICH CAHPS) survey.

BMC Nephrol 2018 Nov 28;19(1):340. Epub 2018 Nov 28.

Tufts Medical Center, 800 Washington Street Box 391, Boston, MA, 02111, USA.

Background: Patient experience in hemodialysis (HD) is measured twice yearly in all in-center HD patients in the United States using the In-Center Hemodialysis Consumer Assessment of Healthcare Providers and Systems (ICH CAHPS) survey. Survey scores are publically available and incorporated into the dialysis payment system. Despite its importance, little is known about factors associated with better experience scores. Read More

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http://dx.doi.org/10.1186/s12882-018-1147-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264620PMC
November 2018
1 Read

Beyond dialysis decisions: a qualitative exploration of decision-making among culturally and linguistically diverse adults with chronic kidney disease on haemodialysis.

BMC Nephrol 2018 Nov 27;19(1):339. Epub 2018 Nov 27.

The University of Sydney, Faculty of Medicine and Health, School of Public Health, Sydney, NSW, Australia.

Background: To date, limited research has been dedicated to exploring the experience of decision-making for chronic kidney disease (CKD) patients who have initiated dialysis and have to make decisions in the context of managing multiple illnesses. Evidence about the experience of decision-making for minority or disadvantaged groups living with CKD (e.g. Read More

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http://dx.doi.org/10.1186/s12882-018-1131-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258454PMC
November 2018

The lived experiences of patients undergoing hemodialysis with the concept of care: a phenomenological study.

BMC Nephrol 2018 Nov 26;19(1):338. Epub 2018 Nov 26.

Nursing and Midwifery Care Research Center, Adult Nursing Department, School of Nursing and Midwifery, Isfahan University of Medical Science, Isfahan, Iran.

Background: Providing patient-centered care needs in patients with chronic renal failure undergoing hemodialysis is important in inspiring their confidence to continue their treatment and promote their mental and social health. Therefore, recognizing the concept of care from the viewpoint of these patients can be helpful in designing the care programs of this vulnerable group. Accordingly, the aim of this study was to reveal the meaning and concept of care based on the experience of patients with chronic renal failure undergoing hemodialysis. Read More

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http://dx.doi.org/10.1186/s12882-018-1138-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258413PMC
November 2018

Significance of histological crescent formation in patients with IgA vasculitis (Henoch-Schönlein purpura)-related nephritis: a cohort in the adult Chinese population.

BMC Nephrol 2018 Nov 22;19(1):334. Epub 2018 Nov 22.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, People's Republic of China.

Background: IgA vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a type of systemic vasculitis. This study aimed to explore the clinicopathological features, treatment and renal outcomes of adult IgAV-related nephritis (Henoch-Schönlein purpura nephritis) patients with different degrees of crescent formation.

Methods: Adult patients with biopsy-proven IgAV-related nephritis in Nanjing Jinling Hospital were enrolled and divided into three groups as follows: control (no crescents, n = 257), group 1 (crescents < 25%, n = 381), and group 2 (crescents ≥25%, n = 60). Read More

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http://dx.doi.org/10.1186/s12882-018-1117-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249918PMC
November 2018
2 Reads
1.520 Impact Factor

Bone marrow mesenchymal stem cells attenuate the progression of focal segmental glomerulosclerosis in rat models.

BMC Nephrol 2018 Nov 22;19(1):335. Epub 2018 Nov 22.

Departmgent of Nephrology (Key laboratory of Zhejiang province, management of kidney disease), Hangzhou Hospital of Traditional Chinese Medicine, Tiyuchang Road 453, Hangzhou, 310007, People's Republic of China.

Background: Focal segmental glomerulosclerosis (FSGS) is the most common glomerular etiology of end-stage kidney disease (ESKD). Increasing evidence has indicated the reparative potential of mesenchymal stem cells (MSCs) in damaged diseased kidneys. However, the effect of bone marrow mesenchymal stem cells (BMSCs) on the FSGS progression remains unclear. Read More

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http://dx.doi.org/10.1186/s12882-018-1137-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249725PMC
November 2018
3 Reads

Glomerular filtration rate: new age- and gender- specific reference ranges and thresholds for living kidney donation.

BMC Nephrol 2018 Nov 22;19(1):336. Epub 2018 Nov 22.

Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background: There is a need for a large, contemporary, multi-centre series of measured glomerular filtration rates (mGFR) from healthy individuals to determine age- and gender-specific reference ranges for GFR. We aimed to address this and to use the ranges to provide age- and gender-specific advisory GFR thresholds considered acceptable for living kidney donation.

Methods: Individual-level data including pre-donation mGFR from 2974 prospective living kidney donors from 18 UK renal centres performed between 2003 and 2015 were amalgamated. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1126-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249883PMC
November 2018
3 Reads

AL amyloidosis with non-amyloid forming monoclonal immunoglobulin deposition; a case mimicking AHL amyloidosis.

BMC Nephrol 2018 Nov 22;19(1):337. Epub 2018 Nov 22.

Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Immunoglobulin heavy-and-light-chain amyloidosis (AHL amyloidosis) is a newly established disease entity where both the immunoglobulin heavy-chain and light-chain compose amyloid fibrils. The immunoglobulins responsible for the amyloid fibrils are generally identified by immunostaining and/or laser microdissection-liquid chromatography-tandem mass spectrometry (LMD-LC-MS/MS). However, both techniques do not biochemically differentiate immunoglobulins that formed amyloid fibrils from non-responsible immunoglobulins. Read More

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http://dx.doi.org/10.1186/s12882-018-1050-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251104PMC
November 2018
4 Reads

Renal dysfunction among adult HIV/AIDS patients on antiretroviral therapy at a tertiary facility in Ghana.

BMC Nephrol 2018 Nov 21;19(1):333. Epub 2018 Nov 21.

Department of Chemical Pathology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.

Background: Kidney diseases have emerged as significant cause of morbidity and mortality in HIV subject on antiretroviral therapy (ART). In Ghana, routine follow up of HIV positive clients is by estimation of serum creatinine and urea levels. Glomerular Filtration Rate (GFR) is not routinely calculated and proteinuria is not routinely checked. Read More

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http://dx.doi.org/10.1186/s12882-018-1130-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249759PMC
November 2018
3 Reads

Pneumocystis jiroveci pneumonia in kidney and simultaneous pancreas kidney transplant recipients in the present era of routine post-transplant prophylaxis: risk factors and outcomes.

BMC Nephrol 2018 Nov 21;19(1):332. Epub 2018 Nov 21.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 1685 Highland Ave, 4177 Medical Foundation Centennial Building, Madison, WI, 53705, USA.

Background: The goal of this study was to identify predictors for development of Pneumocystis jirovecii pneumonia (PJP) in kidney and simultaneous kidney and pancreas transplant recipients in the present era of universal primary prophylaxis.

Methods: We reviewed adult recipients of kidney transplant or simultaneous pancreas and kidney transplant at the University of Wisconsin between January 1, 1994 and December 31, 2016. Patients diagnosed with PJP during this time frame were included. Read More

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http://dx.doi.org/10.1186/s12882-018-1142-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249739PMC
November 2018
5 Reads

An IgA1-lambda-type monoclonal immunoglobulin deposition disease associated with membranous features in a patient with IgG4-related kidney disease: a case report.

BMC Nephrol 2018 Nov 20;19(1):330. Epub 2018 Nov 20.

Department of Nephrology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama, 343-8555, Japan.

Background: IgG4-related disease (IgG4-RD) is a newly recognized fibroinflammatory condition. The kidney is one of the organs commonly affected by IgG4-RD. Tubulointerstitial nephritis (TIN) is the main feature, and membranous nephropathy (MN) has also been described frequently. Read More

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http://dx.doi.org/10.1186/s12882-018-1133-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245818PMC
November 2018
7 Reads

Minimal change nephrotic syndrome in patients infected with human immunodeficiency virus: a retrospective study of 8 cases.

BMC Nephrol 2018 Nov 20;19(1):331. Epub 2018 Nov 20.

AP-HP (Assistance Publique-Hôpitaux de Paris), Service de Néphrologie et de Transplantation, Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Hôpital Henri-Mondor/Albert-Chenevier, F-94000, Créteil, France.

Background: Human immunodeficiency virus (HIV) is associated with diverse glomerular diseases. Characteristics of minimal change nephrotic syndrome (MCNS) in this setting have been little studied, and the specific features of this uncommon association remain to be determined.

Methods: We conduct a retrospective study. Read More

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http://dx.doi.org/10.1186/s12882-018-1132-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247501PMC
November 2018
6 Reads

Troponin I at admission in the intensive care unit predicts the need of dialysis in septic patients.

BMC Nephrol 2018 Nov 20;19(1):329. Epub 2018 Nov 20.

Nephrology Division, Department of Medicine, Universidade Federal Fluminense, Niterói, RJ, Brazil.

Background: In a previous study we showed that troponin I (TnI) > 0.42 ng/mL predicted the need of dialysis in a group of 29 septic patients admitted to the intensive care unit (ICU). We aimed to confirm such finding in a larger independent sample. Read More

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http://dx.doi.org/10.1186/s12882-018-1129-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245612PMC
November 2018
3 Reads

Renal outcomes of STOP-IgAN trial patients in relation to baseline histology (MEST-C scores).

BMC Nephrol 2018 Nov 19;19(1):328. Epub 2018 Nov 19.

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.

Background: The Oxford classification of IgA nephropathy (IgAN) defines histologic criteria (MEST-C) that provide prognostic information based on the kidney biopsy. There are few data on the predictive impact of this classification in randomized clinical trial settings.

Methods: We performed an exploratory analysis of MEST-C scores in 70 available renal biopsies from 162 randomized STOP-IgAN trial participants and correlated the results with clinical outcomes. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1128-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245781PMC
November 2018
9 Reads

Influence of exogenous growth hormone administration on circulating concentrations of α-klotho in healthy and chronic kidney disease subjects: a prospective, single-center open case-control pilot study.

BMC Nephrol 2018 Nov 15;19(1):327. Epub 2018 Nov 15.

Department of Nephrology, VU University Medical Center, De Boelelaan 1117, 1081, HV, Amsterdam, The Netherlands.

Background: The CKD-associated decline in soluble α-Klotho (α-Klotho) levels is considered detrimental. Some studies suggest a direct induction of α-Klotho concentrations by growth hormone (GH). In the present study, the effect of exogenous GH administration on α-Klotho concentrations in a clinical cohort with mild chronic kidney disease (CKD) and healthy subjects was studied. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1114-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238285PMC
November 2018
4 Reads

Serum levels of tumor necrosis factor alpha in patients with IgA nephropathy are closely associated with disease severity.

BMC Nephrol 2018 Nov 14;19(1):326. Epub 2018 Nov 14.

Division of Nephrology, Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, NO.1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Background: Tumor necrosis factor alpha (TNF-α) is considered to play an important role in the pathogenesis in IgA nephropathy (IgAN). The correlations between serum TNF-α and disease severity in patients with IgAN remain controversial.

Methods: Concentrations of serum TNF-α of 147 patients with IgAN and 126 healthy subjects were measured by chemiluminescence immunoassay. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1069-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236996PMC
November 2018
5 Reads

The stability and variability of serum and plasma fibroblast growth factor-23 levels in a haemodialysis cohort.

BMC Nephrol 2018 Nov 14;19(1):325. Epub 2018 Nov 14.

Department of Nephrology, Monash Medical Centre, Monash Health, Clayton, VIC, Australia.

Background: Serum fibroblast growth factor 23 (FGF-23) levels are markedly elevated in haemodialysis patients and have been linked to mortality outcomes. Small studies in health and chronic kidney disease, have demonstrated marked intra- and inter-individual variability in measured FGF-23 levels, and variable degradation in serum as compared to plasma samples. In end-stage kidney disease (ESKD), the intra- and inter-individual variability of FGF-23 levels, and the optimal collection methods remain poorly characterized. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1127-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236962PMC
November 2018
2 Reads

Oral acyclovir induced hypokalemia and acute tubular necrosis a case report.

BMC Nephrol 2018 Nov 14;19(1):324. Epub 2018 Nov 14.

Servicio de Nefrología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.

Background: Acyclovir is one of the most common prescribed antiviral drugs. Acyclovir nephrotoxicity occurs in approximately 12-48% of cases. It can present in clinical practice as acute kidney injury (AKI), crystal-induced nephropathy, acute tubulointerstitial nephritis, and rarely, as tubular dysfunction. Read More

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http://dx.doi.org/10.1186/s12882-018-1121-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236899PMC
November 2018
2 Reads

Effectiveness of contrast-associated acute kidney injury prevention methods; a systematic review and network meta-analysis.

BMC Nephrol 2018 Nov 13;19(1):323. Epub 2018 Nov 13.

Lambe Institute for Translational Research, Discipline of Surgery National University of Ireland, Galway, Republic of Ireland.

Background: Different methods to prevent contrast-associated acute kidney injury (CA-AKI) have been proposed in recent years. We performed a mixed treatment comparison to evaluate and rank suggested interventions.

Methods: A comprehensive Systematic review and a Bayesian network meta-analysis of randomised controlled trials was completed. Read More

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http://dx.doi.org/10.1186/s12882-018-1113-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234687PMC
November 2018
1 Read

Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery.

BMC Nephrol 2018 Nov 12;19(1):320. Epub 2018 Nov 12.

Division of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.

Background: Surgery is one of the leading causes of acute kidney injury (AKI) in hospitalized patients. Major abdominal surgery has the second higher incidences of AKI, after cardiac surgery. AKI results from a complex interaction between hemodynamic, toxic and inflammatory factors. Read More

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http://dx.doi.org/10.1186/s12882-018-1073-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231266PMC
November 2018
1 Read

Monoclonal light chain crystalline podocytopathy and tubulopathy associated with monoclonal gammopathy of renal significance: a case report and literature review.

BMC Nephrol 2018 Nov 12;19(1):322. Epub 2018 Nov 12.

Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, People's Republic of China.

Background: Monoclonal gammopathy of renal significance (MGRS) is a recently defined group of renal diseases caused by monoclonal immunoglobulin secreted by nonmalignant proliferative B cell or plasma cell. Monoclonal immunoglobulin can form different types of structures deposited in renal tissue, including fibrils, granules, microtubules, crystals and casts, and has mostly been reported in multiple myeloma patients. Here we report a rare case with κ light chain crystals in both podocytes and tubular epithelial cells associated with MGRS, which adds more information to the spectrum of MGRS-related renal diseases. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1108-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233383PMC
November 2018
4 Reads
1.520 Impact Factor

The relationship between care burden and quality of life in caregivers of hemodialysis patients.

BMC Nephrol 2018 Nov 12;19(1):321. Epub 2018 Nov 12.

Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Caregivers of hemodialysis patients endure a significant caring pressure as a result of caring for patients with chronic illness, which can affect their quality of life. Disruptions in the quality of life of these caregivers impose double pressure on them and disrupt the care process. Therefore, the present study aimed to determine the level of care burden and its relationship with quality of life of caregivers of hemodialysis patients. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1120-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233261PMC
November 2018
6 Reads

Retroperitoneal abscess with subcutaneous extension: case report of a rare complication of percutaneous renal biopsy.

BMC Nephrol 2018 Nov 9;19(1):319. Epub 2018 Nov 9.

Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Infective complications following percutaneous renal biopsy are rare, even among immunocompromised. However it is important to be vigilant about such complications, to detect them early and prevent morbidity and mortality. We report a case of retroperitoneal abscess with extension to subcutaneous plane after a renal biopsy. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1112-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230226PMC
November 2018
6 Reads

Early predictors of one-year mortality in patients over 65 presenting with ANCA-associated renal vasculitis: a retrospective, multicentre study.

BMC Nephrol 2018 Nov 9;19(1):317. Epub 2018 Nov 9.

Department of Nephrology, Dialysis and Transplantation, Amiens University Hospital, F-80054, Amiens, France.

Background: The risk of early death is particularly high in patients over the age of 65 presenting with antineutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis. We hypothesized that by combining disease severity markers, a comorbidity index and serious adverse event reports, we would be able to identify early predictors of one-year mortality in this population.

Methods: We performed a multicentre, retrospective study in the nephrology and internal medicine departments of six tertiary hospitals in northern France. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1102-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234782PMC
November 2018
4 Reads
1.520 Impact Factor

Trends in anemia care in non-dialysis-dependent chronic kidney disease (CKD) patients in the United States (2006-2015).

BMC Nephrol 2018 Nov 9;19(1):318. Epub 2018 Nov 9.

Department of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL, 32827, USA.

Background: The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and to evaluate the impact of Trial to Reduced Cardiovascular Events with Ananesp Therapy (TREAT)'s study results (October 2009) and the US Food and Drug Administration (FDA)'s (June 2011) safety warnings and guidelines on the use of ESA therapy in the current treatment of anemia.

Methods: A retrospective cohort analysis of anemia management in CKD patients using Truven MarketScan Commercial and Medicare Supplemental databases was conducted. Monthly rates and types of anemia treatment for post-TREAT and post-FDA safety warning periods were compared to pre-TREAT period. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1119-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230235PMC
November 2018
4 Reads

Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress.

BMC Nephrol 2018 Nov 8;19(1):315. Epub 2018 Nov 8.

Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO, USA.

Background: Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum and urinary components involved in stone formation.

Methods: We analyzed a previously published randomized controlled study that included 33 healthy male adults (40-65 years of age) who ingested 200 g of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2 weeks. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1105-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225702PMC
November 2018
3 Reads

Abdominal aortic calcification score can predict future coronary artery disease in hemodialysis patients: a 5-year prospective cohort study.

BMC Nephrol 2018 Nov 8;19(1):313. Epub 2018 Nov 8.

College of Medicine, China Medical University, Taichung, Taiwan.

Background: Abdominal aortic calcification (AAC) has been known to be associated with cardiovascular mortality in hemodialysis. However, the association between AAC and future coronary artery disease (CAD) occurrence is not clear. We aimed to clarify the association of AAC severity and the occurrence of future CAD events in hemodialysis patients. Read More

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http://dx.doi.org/10.1186/s12882-018-1124-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225627PMC
November 2018
1 Read

Female sex reduces the risk of hospital-associated acute kidney injury: a meta-analysis.

BMC Nephrol 2018 Nov 8;19(1):314. Epub 2018 Nov 8.

Department of Medicine, Nephrology Division, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E. 210 St, Bronx, NY, 10467, USA.

Background: Female sex has been included as a risk factor in models developed to predict the development of AKI. In addition, the commentary to the Kidney Disease Improving Global Outcomes Clinical Practice Guideline for AKI concludes that female sex is a risk factor for hospital-acquired AKI. In contrast, a protective effect of female sex has been demonstrated in animal models of ischemic AKI. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1122-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225636PMC
November 2018
4 Reads

Rapidly progressive renal failure due to tubulointerstitial infiltration of peripheral T-cell lymphoma, not otherwise specified accompanied by uveitis: a case report.

BMC Nephrol 2018 Nov 8;19(1):312. Epub 2018 Nov 8.

Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichisita Hebita Ishinomaki, Miyagi, 986-8522, Japan.

Background: Rapid decline in renal dysfunction due to primary renal lymphoma, or secondary renal lymphoma by infiltration from a primary origin, is extremely rare. There are notably few reports indicating infiltration of T-cell lymphoma into the kidney.

Case Presentation: A 61-year-old woman with a sudden body rash and liver dysfunction was brought to our hospital presenting with a dull headache and blurred vision. Read More

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http://dx.doi.org/10.1186/s12882-018-1125-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225725PMC
November 2018

Nephrotic syndrome associated with Kimura's disease: a case report and literature review.

BMC Nephrol 2018 Nov 8;19(1):316. Epub 2018 Nov 8.

Department of Nephrology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West Section 2, Ring 1 Road, Chengdu, 610072, Sichuan, China.

Background: Kimura's disease (KD) is a rare chronic inflammatory disorder with a high incidence of renal involvement. In this report, we present a case study of KD-associated nephrotic syndrome combined with minimal change disease (MCD) and acute renal tubular injury. Meanwhile, the clinical and histopathological characteristics of 26 patients with KD presenting with renal involvement were retrospectively evaluated. Read More

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http://dx.doi.org/10.1186/s12882-018-1123-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225567PMC
November 2018
2 Reads
1.520 Impact Factor

Renal-limited AL amyloidosis - a diagnostic and management dilemma.

BMC Nephrol 2018 Nov 6;19(1):307. Epub 2018 Nov 6.

Unit of Nephrology, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Malaysia.

Background: Amyloidosis is a disorder caused by extracellular tissue deposition of insoluble fibrils which may result in a wide spectrum of symptoms depending upon their types, sites and amount of deposition. Amyloidosis can be divided into either systemic or localized disease.

Case Presentation: We present a case of a middle-aged gentleman who presented with persistent nephrotic syndrome with worsening renal function. Read More

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http://dx.doi.org/10.1186/s12882-018-1118-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219210PMC
November 2018

Assessing the effect of oral activated vitamin D on overall survival in hemodialysis patients: a landmark analysis.

BMC Nephrol 2018 Nov 6;19(1):309. Epub 2018 Nov 6.

Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: Patients with end stage renal disease have a high all-cause and cardiovascular mortality. Secondary hyperparathyroidism and vitamin D deficiency are considered part of the mechanism for the excess mortality observed. We aimed to evaluate the relationship between vitamin D use and all-cause mortality. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1111-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219061PMC
November 2018
5 Reads

The value of non-invasive measurement of cardiac output and total peripheral resistance to categorize significant changes of intradialytic blood pressure: a prospective study.

BMC Nephrol 2018 Nov 6;19(1):310. Epub 2018 Nov 6.

Renal Division, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu, China.

Background: Blood pressure (BP) is currently the main hemodynamic parameter used to assess the influence of fluid removal during hemodialysis session. Since BP is dependent on cardiac output (CO) and total peripheral resistance (TPRI), investigating these parameters may help to better understand the influence of fluid removal on patient's hemodynamics. We used a novel non-invasive whole-body bio-impedance cardiography device, recently validated in hemodialysis patients, to examine mechanisms of intradialytic hemodynamics in a Chinese dialysis population. Read More

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http://dx.doi.org/10.1186/s12882-018-1087-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219191PMC
November 2018
1.520 Impact Factor