2,764 results match your criteria BMC Nephrology[Journal]


Chronic kidney disease in Russia: the Ural eye and medical study.

BMC Nephrol 2020 May 25;21(1):198. Epub 2020 May 25.

Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1, 68167, Mannheim, Germany.

Background: To examine the prevalence of chronic kidney disease (CKD) and its associations in a Russian population.

Methods: Out of 7328 eligible individuals, the population-based cross-sectional Ural Eye and Medical Study included 5899 (80.5%) individuals aged 40+ years and undergoing a detailed medical examination. Read More

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http://dx.doi.org/10.1186/s12882-020-01843-4DOI Listing

Impact of hemodialysis and post-dialysis period on granular activity levels.

BMC Nephrol 2020 May 25;21(1):197. Epub 2020 May 25.

School of Medicine, Pontifícia Universidade Católica do Paraná, Imaculada Conceição, 1155, Curitiba, PR, 80215-901, Brazil.

Background: Physical activity (PA) is typically lower on hemodialysis (HD) days. Albeit intradialytic inactivity is expected, it is unknown whether recovery after HD contributes to low PA. We investigated the impact of HD and post-HD period on granular PA relative to HD timing. Read More

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http://dx.doi.org/10.1186/s12882-020-01853-2DOI Listing

Percutaneous insertion of peritoneal dialysis catheter is a safe and effective technique irrespective of BMI.

BMC Nephrol 2020 May 25;21(1):199. Epub 2020 May 25.

Department of Nephrology, the First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), National Clinical Research Center for Kidney Diseases, Fuxing Road 28, Beijing, 100853, People's Republic of China.

Background: A large body mass index (BMI) has been considered as a relative contraindication for percutaneous catheter insertion, although this technique has many advantages. Up to now, there are few studies on peritoneal catheter placement and obesity. The aim of this study was to determine whether patients with large BMI can also choose the percutaneous technique for peritoneal dialysis catheter insertion. Read More

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http://dx.doi.org/10.1186/s12882-020-01850-5DOI Listing

Primary antiphospholipid syndrome associated with anti-phospholipase A2 receptor antibody-positive membranous nephropathy.

BMC Nephrol 2020 May 24;21(1):196. Epub 2020 May 24.

Nephrology, dialysis and apheresis unit, University of Montpellier-Nimes, CHU de Nîmes, Rue du Professeur Robert Debré, Nîmes, France.

Background: The kidney is a major target in primary antiphospholipid syndrome. Several types of nephropathy have been reported, the most frequent being acute or chronic specific vascular nephropathies and membranous nephropathy.

Case Presentation: A 59-year-old male presented in our unit with nephrotic syndrome. Read More

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http://dx.doi.org/10.1186/s12882-020-01856-zDOI Listing

IgM monoclonal gammopathy with heavy-and-light-chain amyloidosis resembling fibrillary glomerulonephritis determined by tandem mass spectrometry: a case report.

BMC Nephrol 2020 May 24;21(1):195. Epub 2020 May 24.

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Background: Fibrillary glomerulonephritis (FGN) is distinguished from amyloidosis by thicker fibrils and the lack of staining with histochemical dyes typically reactive with amyloid. However, congophilic FGN has been proposed recently and adding laser microdissection followed by mass spectrometry (LMD/MS) to conventional pathological methods would be helpful to diagnose FGN. Here, we report a patient initially diagnosed with FGN whose final pathological diagnosis was changed to immunoglobulin heavy-and-light-chain amyloidosis (AHL) after LMD/MS. Read More

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http://dx.doi.org/10.1186/s12882-020-01851-4DOI Listing

Non-invasive venous waveform analysis (NIVA) for volume assessment in patients undergoing hemodialysis: an observational study.

BMC Nephrol 2020 May 24;21(1):194. Epub 2020 May 24.

Vanderbilt University Medical Center, S111 Medical Center North, 21st Ave South, Medical Art Building 422, Nashville, TN, 37212, USA.

Background: Accurate assessment of volume status to direct dialysis remains a clinical challenge. Despite current attempts at volume-directed dialysis, inadequate dialysis and intradialytic hypotension (IDH) are common occurrences. Peripheral venous waveform analysis has recently been developed as a method to accurately determine intravascular volume status through algorithmic quantification of changes in the waveform that occur at different volume states. Read More

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http://dx.doi.org/10.1186/s12882-020-01845-2DOI Listing

Aspiration-sclerotherapy versus laparoscopic de-roofing in the treatment of renal cysts: which is better?

BMC Nephrol 2020 May 24;21(1):193. Epub 2020 May 24.

Department of Urology, West China Hospital, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, People's Republic of China.

Background: To compare the clinical efficiency between aspiration-sclerotherapy (AS) and laparoscopic de-roofing (LD) in the management of renal cysts through meta-analysis of comparative studies.

Method: A comprehensive literature search was performed by PubMed, MEDLINE, Ovid and Web of Science for relevant studies published up to January 2020. The statistical analyses were conducted with Review Manager 5. Read More

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http://dx.doi.org/10.1186/s12882-020-01832-7DOI Listing

Arterial reconstruction using the donor's gonadal vein in living renal transplantation with multiple renal arteries: a case report and a literature review.

BMC Nephrol 2020 May 20;21(1):190. Epub 2020 May 20.

Department of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Arterial reconstruction is one of the paramount procedures in kidney transplantation (KT) and greatly important if the procured kidney has multiple renal arteries (MRA). Despite various established techniques for arterial reconstruction, sometimes, the surgeon finds performing arterial anastomoses challenging in case of MRA. In our case, the donor's gonadal vein and recipient's internal iliac artery graft were used for arterial anastomoses, and 3 years after KT, the allograft did not present vascular complications. Read More

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http://dx.doi.org/10.1186/s12882-020-01848-zDOI Listing

Implementation of a quality improvement strategy to increase outpatient kidney transplant referrals.

BMC Nephrol 2020 May 20;21(1):192. Epub 2020 May 20.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, Box 1243, One Gustave L. Levy Place, New York, NY, 10029, USA.

Background: Kidney transplantation remains the optimal therapy for patients with end stage kidney disease (ESKD), though a small fraction of patients on dialysis are on organ waitlists. An important barrier to both preemptive kidney transplantation and successful waitlisting is timely referral to a kidney transplant center. We implemented a quality improvement strategy to improve outpatient kidney transplant referrals in a single center academic outpatient nephrology clinic. Read More

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http://dx.doi.org/10.1186/s12882-020-01855-0DOI Listing

Incidence of acute kidney injury and use of renal replacement therapy in intensive care unit patients in Indonesia.

BMC Nephrol 2020 May 20;21(1):191. Epub 2020 May 20.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Currently, there is limited epidemiology data on acute kidney injury (AKI) in Indonesia. Therefore, we assessed the incidence of AKI and the utilization of renal replacement therapy (RRT) in Indonesia.

Methods: Demographic and clinical data were collected from 952 ICU participants. Read More

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http://dx.doi.org/10.1186/s12882-020-01849-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238547PMC

Ten-year outcome of Eculizumab in kidney transplant recipients with atypical hemolytic uremic syndrome- a single center experience.

BMC Nephrol 2020 May 20;21(1):189. Epub 2020 May 20.

Department of Medicine, Division of Nephrology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Carnegie 344B, Baltimore, Maryland, 21287, USA.

Background: Atypical hemolytic uremic syndrome (aHUS) can result in severe kidney dysfunction, secondary to thrombotic microangiopathy. Eculizumab has been used to treat this disorder, and has resulted in favourable outcomes in both, native and transplanted kidneys. There is limited long term follow up data in kidney transplant recipients (KTRs) who received prevention and treatment with Eculizumab. Read More

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http://dx.doi.org/10.1186/s12882-020-01847-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238522PMC

Ion-Channel modulator TH1177 reduces glomerular injury and serum creatinine in chronic mesangial proliferative disease in rats.

BMC Nephrol 2020 May 19;21(1):187. Epub 2020 May 19.

Renal Sciences, Department of Inflammation Biology, King's College London, Renal Medicine 10 Cutcombe Road, London, SE5 9RJ, UK.

Background: T-type calcium channels (TTCC) are involved in mesangial cell proliferation. In acute thy-1 nephritis in the rat TTCC inhibition reduces glomerular damage and cell proliferation. This work is extended here by a study of the non-selective TTCC inhibitor TH1177 in a chronic model of proliferative glomerulonephritis (GN) including late treatment starting after the initial inflammation has resolved. Read More

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http://dx.doi.org/10.1186/s12882-020-01842-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236127PMC

Childhood socioeconomic status, comorbidity of chronic kidney disease risk factors, and kidney function among adults in the midlife in the United States (MIDUS) study.

BMC Nephrol 2020 May 19;21(1):188. Epub 2020 May 19.

Department of Human Development and Family Studies/ Center for Healthy Aging, The Pennsylvania State University, 405 Biobehavioral Health (BBH) Building, University Park, PA, 16802, USA.

Background: There is a lack of empirical effort that systematically investigates the clustering of comorbidity among known risk factors (obesity, hypertension, diabetes, hypercholesterolemia, and elevated inflammation) of chronic kidney disease (CKD) and how different types of comorbidity may link differently to kidney function among healthy adult samples. This study modeled the clustering of comorbidity among risk factors, examined the association between the clustering of risk factors and kidney function, and tested whether the clustering of risk factors was associated with childhood SES.

Methods: The data were from 2118 participants (ages 25-84) in the Midlife in the United States (MIDUS) Study. Read More

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http://dx.doi.org/10.1186/s12882-020-01846-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236129PMC

Crystalglobulin-associated nephropathy presenting as MGRS in a case of monoclonal B-cell lymphocytosis: a case report.

BMC Nephrol 2020 May 18;21(1):184. Epub 2020 May 18.

Department of Nephrology, SUNY Upstate Medical University, Syracuse, NY, USA.

Background: Crystalglobulin-associated nephropathy (CAN), a rare subtype of monoclonal gammopathy, usually associated with multiple myeloma and occasionally monoclonal gammopathy of uncertain significance (MGUS), is characterized by occluding monoclonal pseudothrombi within renal glomerular capillaries and/or interstitial arterioles. Ultrastructurally, these pseudothrombi are unique for having a crystalline substructure. We describe a case of an adult patient with monoclonal B-cell lymphocytosis (MBL) and acute renal failure whose kidney biopsy revealed a rare diagnosis of CAN. Read More

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http://dx.doi.org/10.1186/s12882-020-01818-5DOI Listing

Glomerulonephritis Histopathological Pattern Change.

BMC Nephrol 2020 May 18;21(1):186. Epub 2020 May 18.

Mubarak Al-Kabeer Hospital, Department of Internal Medicine, Nephrology Unit, Jabriya, Kuwait.

Background: Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center. Read More

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http://dx.doi.org/10.1186/s12882-020-01836-3DOI Listing

Quality of life improved for patients after starting dialysis but is impaired, initially, for their partners: a multi-centre, longitudinal study.

BMC Nephrol 2020 May 18;21(1):185. Epub 2020 May 18.

School of Health Sciences, Division of Psychology and Mental Health, Manchester Centre for Health Psychology, University of Manchester, Manchester, UK.

Background: Quality of life (QOL) is important to patients with end stage renal disease and their partners. Despite the first 12 weeks being a critical time in the treatment pathway, limited research exists which examines how the transition onto dialysis impacts QOL. In this study we measured QOL in patients and their partners at pre-dialysis and over the first 12 weeks on dialysis to investigate QOL during this crucial period. Read More

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http://dx.doi.org/10.1186/s12882-020-01819-4DOI Listing

Effects of parathyroid hormone and vitamin D supplementation on stroke among patients receiving peritoneal dialysis.

BMC Nephrol 2020 May 18;21(1):183. Epub 2020 May 18.

Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, 325000, Zhejiang, P. R. China.

Background: Continuous ambulatory peritoneal dialysis (CAPD) patients have a high incidence of stroke and commonly have increased parathyroid hormone levels and vitamin D insufficiency. We seek to investigate the incidence of stroke and the role of parathyroid hormone and vitamin D supplementation in stroke risk among CAPD patients.

Methods: This study employed a retrospective design. Read More

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http://dx.doi.org/10.1186/s12882-020-01817-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236177PMC

Urinary angiotensinogen as a surrogate marker predicting the antiproteinuric effects of angiotensin receptor blockers in patients with overt proteinuria: a multicenter prospective study.

BMC Nephrol 2020 May 1;21(1):180. Epub 2020 May 1.

Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Background: Although urinary angiotensinogen (AGT) and renin reflect intrarenal renin-angiotensin system activity and are enhanced in proteinuric chronic kidney disease, the clinical value of urinary AGT and renin levels during antiproteinuric treatment has yet to be determined. We investigated the clinical usefulness of initial urinary AGT or renin to determine the antiproteinuric effects of angiotensin receptor blockers (ARBs).

Methods: This multicenter, prospective, single-arm study included 205 patients with overt proteinuria (urinary protein/creatinine ratio [uPCR] ≥ 1 mg/mg) enrolled between April 2009 and December 2011. Read More

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http://dx.doi.org/10.1186/s12882-020-01825-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227290PMC

IgA nephropathy associated with thalassemia: a case report.

BMC Nephrol 2020 May 14;21(1):182. Epub 2020 May 14.

The Department of Nephrology (Key laboratory of management of kidney disease in Zhejiang province), Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, P. R. China.

Background: Thalassemia is a group of hereditary diseases characterized by a common recessive monogenic hematological disorder, presenting a significant public health concern in the developing countries. Recent studies have identified the renal effects of thalassemia syndrome. Chronic hypoxia, long-term anemia, iron overload, and iron chelators are the major causes of renal tubular dysfunction and glomerular filtration abnormalities, while glomerulonephritis is not considered a major cause of abnormal urinalysis. Read More

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http://dx.doi.org/10.1186/s12882-020-01844-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227039PMC

Benefits of peritoneal ultrafiltration in HFpEF and HFrEF patients.

BMC Nephrol 2020 May 14;21(1):179. Epub 2020 May 14.

Department of Kidney-, Blood Pressure- and Autoimmune Diseases, Katharinenhospital, Klinikum Stuttgart, Stuttgart, Germany.

Background: Peritoneal ultrafiltration (pUF) in refractory heart failure (HF) reduces the incidence of decompensation episodes, which is of particular significance as each episode incrementally adds to mortality. Nevertheless, there are insufficient data about which patient cohort benefits the most. The objective of this study was to compare pUF in HFrEF and HFpEF, focusing on functional status, hospitalizations, surrogate endpoints and mortality. Read More

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http://dx.doi.org/10.1186/s12882-020-01777-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222460PMC

Acute kidney injury after nephrectomy: a new nomogram to predict postoperative renal function.

BMC Nephrol 2020 May 14;21(1):181. Epub 2020 May 14.

Department of Nephrology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.

Background: We aimed to develop a nomogram based on preprocedural features for early prediction of acute kidney injury (AKI) and to assess the prognosis in patients after radical and partial nephrectomy.

Methods: The study included a development cohort of 1111 patients who were treated between June 2012 and June 2017 and an additional validation cohort of 356 patients who were treated between July 2017 and June 2018. Stepwise regression and logistic regression analyses were used to evaluate the association between predictors and AKI. Read More

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http://dx.doi.org/10.1186/s12882-020-01839-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227356PMC
May 2020
1.520 Impact Factor

Low-dose alemtuzumab induction in a tailored immunosuppression protocol for sensitized kidney transplant recipients.

BMC Nephrol 2020 May 13;21(1):178. Epub 2020 May 13.

Department of Diabetology, Endocrinology, Nephrology, Section of Nephrology and Hypertension, University of Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.

Background: Induction therapy is crucial in kidney transplantation and constitutes an important cornerstone for long-term allograft survival. Alemtuzumab is a depleting CD52-specific antibody with T- and B-cell activity, leading to prolonged lymphocyte depletion for up to 12 months, with profound immunosuppression and an associated risk of serious infections. Current concepts aim to optimize dosing strategies to reduce side effects. Read More

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http://dx.doi.org/10.1186/s12882-020-01767-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218828PMC

Kidney-targeted baicalin-lysozyme conjugate ameliorates renal fibrosis in rats with diabetic nephropathy induced by streptozotocin.

BMC Nephrol 2020 May 12;21(1):174. Epub 2020 May 12.

Nursing department, Xiang'An Hospital, Xiamen University, Xiamen, 361005, China.

Background: Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes, and is the most important cause of death for diabetic patients. Baicalin (BAI) has anti-oxidative, anti-inflammatory and anti-apoptotic activities, which play a role in attenuating insulin resistance and protecting the kidney. Moreover, cell-specific targeting of renal tubular cells is an approach to enhance drug accumulation in the kidney. Read More

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http://dx.doi.org/10.1186/s12882-020-01833-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216346PMC

Heavy chain deposition disease presenting with raised anti-GBM antibody levels; a case report.

BMC Nephrol 2020 May 12;21(1):175. Epub 2020 May 12.

Renal Unit, Royal Berkshire Hospital, London Road, Reading, Berkshire, UK.

Background: Monoclonal immunoglobulin deposition disease (MIDD) is a rare condition accounting for < 1% of histopathological diagnoses made on kidney biopsy. The best outcomes are seen in those diagnosed and treated promptly, but delay to diagnosis is common with the largest series reporting a median time from onset of renal impairment to diagnosis of 12 months. Here, we report a case of the heavy chain subset of MIDD presenting with positive anti-glomerular basement membrane (anti-GBM) antibodies obscuring the true diagnosis. Read More

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http://dx.doi.org/10.1186/s12882-020-01837-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216388PMC

Interaction between serum FGF-23 and PTH in renal phosphate excretion, a case-control study in hypoparathyroid patients.

BMC Nephrol 2020 May 12;21(1):176. Epub 2020 May 12.

Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, P.O. Box: 71345-1744, Shiraz, Iran.

Background: phosphate homeostasis is mediated through complex counter regulatory feed-back balance between parathyroid hormone, FGF-23 and 1,25(OH)2D. Both parathyroid hormone and FGF-23 regulate proximal tubular phosphate excretion through signaling on sodium- phosphate cotransporters II and II. However, the interaction between these hormones on phosphate excretion is not clearly understood. Read More

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http://dx.doi.org/10.1186/s12882-020-01826-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218502PMC

Burnout syndrome among nephrologists - a burning issue - results of the countrywide survey by the Polish Society of Nephrology.

BMC Nephrol 2020 May 12;21(1):177. Epub 2020 May 12.

Medical University of Lodz, Department of Nephrology, Hypertension and Kidney Transplantation, Pomorska Str. 251, 92-213, Lodz, Poland.

Background: Burnout syndrome in physicians is associated with adverse patient safety events, poorer quality of care and reduced patients' satisfaction. There has been scarce information on the risk factors of burnout affecting professionals working in the renal care settings. As yet the phenomenon has not been studied in the population of Polish nephrologists therefore a nationwide cross-sectional study was established by the Polish Society of Nephrology to assess the prevalence of the syndrome. Read More

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http://dx.doi.org/10.1186/s12882-020-01829-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218642PMC

Podocytic infolding in Schimke immuno-osseous dysplasia with novel SMARCAL1 mutations: a case report.

BMC Nephrol 2020 May 11;21(1):170. Epub 2020 May 11.

Department of Pediatrics, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Background: Schimke immuno-osseous dysplasia (SIOD) is a rare autosomal recessive disorder characterized by spondyloepiphyseal dysplasia, progressive renal insufficiency and defective cellular immunity. Podocytic infolding glomerulopathy (PIG) is a newly proposed disease entity characterized by microspheres or microtubular structures associated with podocytes infolding into the glomerular basement membrane (GBM) on electron microscopy (EM).

Case Presentation: A 4-year-old boy was admitted to our ward due to proteinuria and edema lasting 1 month. Read More

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http://dx.doi.org/10.1186/s12882-020-01809-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216528PMC

Case report: a Chinese girl with dent disease 1 and turner syndrome due to a hemizygous CLCN5 gene mutation and Isochromosome (Xq).

BMC Nephrol 2020 May 11;21(1):171. Epub 2020 May 11.

Department of Nephrology, The Children's Hospital of Zhejiang University School of Medicine, #57 Zhugan Lane, Hangzhou, 310003, China.

Background: Female Dent disease 1 patients with low-molecular-weight proteinuria (LMWP) due to CLCN5 gene mutation were rarely reported, and these cases that the people were also with Turner syndrome (TS) were even hardly documented before.

Case Presentation: Here we report a 3-year and 11-month old Chinese girl with short stature who had a karyotype of 46,X,i(X)(q10) and a de novo pathogenic variant in the CLCN5 gene on the short arm of X chromosome. Laboratory examinations showed that the patient had LMWP, hypercalciuria, hypophosphatemia, delayed bone age, and genital dysplasia. Read More

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http://dx.doi.org/10.1186/s12882-020-01827-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216489PMC

Effects of exercise training on proteinuria in adult patients with chronic kidney disease: a systematic review and meta-analysis.

BMC Nephrol 2020 May 11;21(1):172. Epub 2020 May 11.

Fujian Medical University Union Hospital, No. 29 of Xinquan Road, Fuzhou City, Fujian Province, China.

Background: Rehabilitation effects of exercise training on adults with chronic kidney disease (CKD) have been generally recognised; however, the effects of exercise training on proteinuria have been underexplored. Our aim was to explore the effects of exercise training on proteinuria in adult CKD patients without renal replacement therapy.

Methods: Randomised controlled trials (RCTs) and quasi-experimental studies examining the effects of exercise training on proteinuria in adults CKD patients without renal replacement therapy were searched in 10 electronic databases (MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database, SPORTDiscus with full text, Web of Science, China Wan Fang Database, China National Knowledge Internet, China Science and Technology Journal Database) until June 2019. Read More

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http://dx.doi.org/10.1186/s12882-020-01816-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216591PMC

Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice.

BMC Nephrol 2020 May 11;21(1):173. Epub 2020 May 11.

Department of Pharmacology & Toxicology, Virginia Commonwealth University School of Medicine, P.O. Box 980613, Richmond, VA, 23298, USA.

Background: Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingolipids and produced by sphingosine kinases (SphK1 and SphK2). SphK1/S1P pathway is implicated in the progression of chronic kidney disease. However, the role of SphK1/S1P pathway in renal injury in hypertension has not been reported. Read More

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http://dx.doi.org/10.1186/s12882-020-01815-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216348PMC

Association between lifestyle factors and decreased kidney function in older adults: a community-based cross-sectional analysis of the Taipei City elderly health examination database.

BMC Nephrol 2020 May 8;21(1):169. Epub 2020 May 8.

Department of Pathology & Laboratory Medicine, Taoyuan Armed Forces General Hospital, No.168, Chung-Shing Rd., Long-Tang District, Taoyuan City, 325, Taiwan, Republic of China.

Background: Impaired kidney function is the hallmark of chronic kidney disease (CKD), and is associated with increased risk of all-cause mortality in the elderly. In the present cross-sectional population-based study, we aimed to evaluate the associations between lifestyle factors (exercise habit, alcohol consumption, smoking history, and betel nut chewing) and decreased kidney function.

Methods: The data from the Taipei City Elderly Health Examination Database (2006 to 2012) were extracted. Read More

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http://dx.doi.org/10.1186/s12882-020-01838-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206742PMC
May 2020
1.520 Impact Factor

Correction to: The urinary microbiome shows different bacterial genera in renal transplant recipients and non-transplant patients at time of acute kidney injury - a pilot study.

BMC Nephrol 2020 May 7;21(1):168. Epub 2020 May 7.

Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s12882-020-01835-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203862PMC

Kidney disease progression and all-cause mortality across estimated glomerular filtration rate and albuminuria categories among patients with vs. without type 2 diabetes.

BMC Nephrol 2020 May 7;21(1):167. Epub 2020 May 7.

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.

Background: Studies of progression of kidney dysfunction typically focus on renal replacement therapy or percentage decline in estimated glomerular filtration rate (eGFR) as outcomes. Our aim was to compare real-world patients with and without T2D to estimate progression from and to clinically defined categories of kidney disease and all-cause mortality.

Methods: This was an observational cohort study of 31,931 patients with and 33,201 age/sex matched patients without type 2 diabetes (T2D) who had a serum creatinine and urine albumin-to-creatinine ratio (UACR) or dipstick proteinuria (DP) values. Read More

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http://dx.doi.org/10.1186/s12882-020-01792-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203828PMC

The association between serum chloride levels and chronic kidney disease progression: a cohort study.

BMC Nephrol 2020 May 6;21(1):165. Epub 2020 May 6.

Division of Nephrology, Department of Medicine, NYU Winthrop Hospital, 200 Old Country Rd, Ste 135, Mineola, NY, 11501, USA.

Background: Limited data suggest serum chloride levels associate with mortality in heart failure, chronic kidney disease (CKD), and pulmonary arterial hypertension. Randomized trials have also shown that administration of crystalloid intravenous fluids with lower chloride concentration may have better renal outcomes. However, chloride has not been studied longitudinally for CKD progression. Read More

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http://dx.doi.org/10.1186/s12882-020-01828-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203999PMC

Gait speed and handgrip strength as predictors of all-cause mortality and cardiovascular events in hemodialysis patients.

BMC Nephrol 2020 May 6;21(1):166. Epub 2020 May 6.

Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, South Korea.

Background: Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commonly used methods of assessing physical performance.

Methods: We obtained data regarding gait speed and handgrip strength from 277 hemodialysis patients and evaluated their relationships with baseline parameters, mental health, plasma inflammatory markers, and major adverse clinical outcomes. Read More

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http://dx.doi.org/10.1186/s12882-020-01831-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203881PMC

Effects of bodybuilding supplements on the kidney: A population-based incidence study of biopsy pathology and clinical characteristics among middle eastern men.

BMC Nephrol 2020 May 6;21(1):164. Epub 2020 May 6.

Department of Pathology, University of Sulaimani College of Medicine and Shoresh Teaching Hospital, Quirga Road, Sulaimani, Iraq.

Background: The incidence of kidney diseases among bodybuilders is unknown.

Methods: Between January 2011 and December 2019, the Iraqi Kurdistan 15 to 39 year old male population averaged 1,100,000 with approximately 56,000 total participants and 25,000 regular participants (those training more than 1 year). Annual age specific incidence rates (ASIR) with (95% confidence intervals) per 100,000 bodybuilders were compared with the general age-matched male population. Read More

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http://dx.doi.org/10.1186/s12882-020-01834-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203829PMC

Application of group LASSO regression based Bayesian networks in risk factors exploration and disease prediction for acute kidney injury in hospitalized patients with hematologic malignancies.

BMC Nephrol 2020 May 5;21(1):162. Epub 2020 May 5.

Department of Nephrology, Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Xuhui District, Shanghai, 200032, China.

Background: Patients who were diagnosed with hematologic malignancies (HM) had a higher risk of acute kidney injury (AKI). This study applies the Bayesian networks (BNs) to investigate the interrelationships between AKI and its risk factors among HM patients, and to evaluate the predictive and inferential ability of BNs model in different clinical settings.

Methods: During 2014 and 2015, a total of 2501 inpatients with HM were recruited in this retrospective study conducted in a tertiary hospital, Shanghai of China. Read More

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http://dx.doi.org/10.1186/s12882-020-01786-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201633PMC
May 2020
1.520 Impact Factor

Intradialytic complications among patients on twice-weekly maintenance hemodialysis: an experience from a hemodialysis center in Eritrea.

BMC Nephrol 2020 May 5;21(1):163. Epub 2020 May 5.

Department of Internal Medicine, Orotta College of Medicine and Health Sciences and Orotta National Referral Hospital, Asmara, Eritrea.

Background: Twice-weekly maintenance hemodialysis sessions in patients with end stage renal disease are commonly practiced due to economic constraints in developing countries including Eritrea. To ameliorate the paucity of data on the subject, our study aims to shed light on the patterns of intradialytic complications exclusively in patients undergoing twice-weekly hemodialysis in the country.

Methods: A descriptive cross-sectional study was conducted from March 01 to July 31, 2018 at Dialysis Unit of Orotta National Referral Hospital, Asmara, Eritrea in patients with end stage renal disease undergoing twice-weekly hemodialysis. Read More

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http://dx.doi.org/10.1186/s12882-020-01806-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201639PMC

Developing quality indicators for Chronic Kidney Disease in primary care, extractable from the Electronic Medical Record. A Rand-modified Delphi method.

BMC Nephrol 2020 May 5;21(1):161. Epub 2020 May 5.

Academic Center for General Practice, Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 33 blok J, 3000, Leuven, Belgium.

Background: Chronic kidney disease (CKD) is a common chronic condition and a rising public health issue with increased morbidity and mortality, even at an early stage. Primary care has a pivotal role in the early detection and in the integrated management of CKD which should be of high quality. The quality of care for CKD can be assessed using quality indicators (QIs) and if these QIs are extractable from the electronic medical record (EMR) of the general physician, the number of patients whose quality of care can be evaluated, could increase vastly. Read More

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http://dx.doi.org/10.1186/s12882-020-01788-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201612PMC

Dehydration-associated chronic kidney disease: a novel case of kidney failure in China.

BMC Nephrol 2020 May 4;21(1):159. Epub 2020 May 4.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.

Background: Mesoamerican nephropathy (MeN) is a pattern of chronic kidney disease (CKD) prevalent among Central American men who work in agriculture, and its underlying cause has not been elucidated. Currently, experts hypothesize that MeN is related to repeated episodes of occupational heat stress leading to water loss and hence it is also called dehydration-associated CKD.

Case Presentation: We report a case of a 40-year-old man, whose first admission to Peking Union Medical College Hospital was due to acute kidney injury (AKI). Read More

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http://dx.doi.org/10.1186/s12882-020-01804-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199376PMC

The predictive role of serum calprotectin on mortality in hemodialysis patients with high phosphoremia.

BMC Nephrol 2020 May 4;21(1):158. Epub 2020 May 4.

Department of Nephrology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan.

Background: The inflammatory mediator calprotectin (CPT, myeloid-related protein 8/14) is known as an endogenous ligand contributing to pathophysiology in inflammatory diseases. Serum CPT reportedly became a potential biomarker in these conditions, though there is no report predicting the prognosis in hemodialysis patients. The aim of this study is to investigate the predictive role of serum CPT on mortality in hemodialysis patients. Read More

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http://dx.doi.org/10.1186/s12882-020-01812-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197146PMC

Quality of life among caregivers of people with end-stage kidney disease managed with dialysis or comprehensive conservative care.

BMC Nephrol 2020 May 4;21(1):160. Epub 2020 May 4.

National Health and Medical Research Council (NHMRC) Clinical Trials Centre, The University of Sydney, 92-94 Parramatta Road, Camperdown, NSW, 2050, Australia.

Background: To measure health-related and care-related quality of life among informal caregivers of older people with end-stage kidney disease (ESKD), and to determine the association between caregiver quality of life and care recipient's treatment type.

Methods: A prospective cross-sectional study was conducted. Three renal units in the UK and Australia were included. Read More

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http://dx.doi.org/10.1186/s12882-020-01830-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199363PMC

Systematic review and meta-analysis of clinical outcomes comparison between different initial dialysis modalities in end-stage renal disease patients due to lupus nephritis prior to renal transplantation.

BMC Nephrol 2020 May 1;21(1):156. Epub 2020 May 1.

Department of Nephrology and Rheumatology, Xiangya Third Hospital, Central South University, Changsha City, Hunan Province, People's Republic of China.

Background: Regarding lupus disease activity, morbidity and survival, limited literature concluded conflicting results when comparing hemodialysis versus peritoneal dialysis as initial renal replacement therapies (RRT) prior to transplantation, in lupus nephritis end-stage renal disease (LN-ESRD) patients. This study was aimed to compare the risks of lupus flares, all-cause infections, all-cause cardiovascular events, and mortality, between hemodialysis versus peritoneal dialysis as initial RRT - modality before renal-transplant in LN-ESRD patients, by systematic review and meta-analysis.

Methods: PubMed, EMBASE, and SCOPUS were searched for observational-studies comparing LN-ESRD -patients undergoing hemodialysis (Group1) versus peritoneal-dialysis (Group 2) prior to renal-transplantation, by their risks of lupus flare, all-cause infections, all-cause cardiovascular events, and mortality as outcome measures. Read More

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http://dx.doi.org/10.1186/s12882-020-01811-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195760PMC

Secondary oxalosis induced by xylitol concurrent with lithium-induced nephrogenic diabetes insipidus: a case report.

BMC Nephrol 2020 May 1;21(1):157. Epub 2020 May 1.

Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine and Hospital, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.

Background: Xylitol is an approved food additive that is widely used as a sweetener in many manufactured products. It is also used in pharmaceuticals. Secondary oxalosis resulting from high dietary oxalate has been reported. Read More

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http://dx.doi.org/10.1186/s12882-020-01814-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195762PMC

Does ligation of the dorsal branch of the cephalic vein affect the patency of a distal forearm arteriovenous fistula? A randomised study.

BMC Nephrol 2020 Apr 29;21(1):155. Epub 2020 Apr 29.

Blood Purification Center, The People's Hospital of Zhengzhou University, Zhengzhou, China.

Background: Whether ligation of the dorsal branch of the cephalic vein during the surgical establishment of the radiocephalic arteriovenous fistula (RCAVF) favorably or adversely affects the patency rate of the RCAVF remains controversial. We performed a randomized controlled trial to evaluate the effect of dorsal branch ligation on the patency rate of RCAVF.

Methods: A total of 115 patients who underwent surgical establishment were randomized to two groups treated with or without ligation of the dorsal branch of the cephalic vein during the surgical process. Read More

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http://dx.doi.org/10.1186/s12882-020-01823-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191813PMC

Association between extracellular volume control and survival in patients on short daily haemodialysis.

BMC Nephrol 2020 Apr 29;21(1):153. Epub 2020 Apr 29.

Postgraduation Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil.

Background: Fluid overload (FO) assessed by bioimpedance spectroscopy (BIS) is associated with higher mortality risk in maintenance haemodialysis (HD). The aim was to assess if a better management of FO through short daily haemodialysis (SDHD) could improve survival.

Methods: Retrospective analysis of patients who were on HD 3 sessions/week for at least 3 months and shifted to in-centre SDHD (5 or 6 sessions/week, 2 to 3 h/session) between July 2012 and June 2016 at 23 dialysis units in Brazil. Read More

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http://dx.doi.org/10.1186/s12882-020-01821-wDOI Listing

Oral health-related quality of life in adult patients with end-stage kidney diseases undergoing renal replacement therapy - a systematic review.

BMC Nephrol 2020 Apr 29;21(1):154. Epub 2020 Apr 29.

Department of Cariology, Endodontology and Periodontology, University of Leipzig, Liebigstr. 12, D 04103, Leipzig, Germany.

Background: The oral health of patients undergoing renal replacement therapy (RRT) is insufficient. Poor oral health and its components can affect the oral health-related quality of life (OHRQoL) of these patients. The aim of this systematic review was to assess the OHRQoL of adult patients under RRT. Read More

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http://dx.doi.org/10.1186/s12882-020-01824-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191826PMC

Abdominal aortic calcification score as a predictor of clinical outcome in peritoneal dialysis patients: a prospective cohort study.

BMC Nephrol 2020 Apr 30;21(1):151. Epub 2020 Apr 30.

Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Pudong District, Shanghai, 200127, People's Republic of China.

Background: Abdominal aortic calcification assessed by X-ray is recommended to evaluate vascular calcification in dialysis patients. It has been shown that abdominal aortic calcification score (AACS) is a predictor of adverse outcomes in hemodialysis patients, but evidence regarding its prognostic value in peritoneal dialysis (PD) patients is still insufficient. We aimed to examine the predictive role of AACS for major adverse cardiac and cerebrovascular events (MACCE) and mortality in PD patients. Read More

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http://dx.doi.org/10.1186/s12882-020-01822-9DOI Listing

Incidence and mortality of new-onset glucose disorders in peritoneal dialysis patients in China: a meta-analysis.

BMC Nephrol 2020 Apr 29;21(1):152. Epub 2020 Apr 29.

Department of Nephrology, Beijing LuHe Hospital, Capital Medical University, No. 82 Xinhua South Road, Tongzhou District, Beijing, 101100, China.

Background: Dialysis patients are at high risk of developing glucose metabolism disturbances (GMDs), such as diabetes mellitus (DM), impaired fast glucose (IFG), and impaired glucose tolerance (IGT). However, it is unclear about the incidence of GMDs in Chinese patients with peritoneal dialysis (PD), as well as the influence of new-onset DM (NODM) on the prognosis of PD patients. Therefore, we conducted this meta-analysis to address these issues. Read More

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http://dx.doi.org/10.1186/s12882-020-01820-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191695PMC

Variation in contrast-associated acute kidney injury prophylaxis for percutaneous coronary intervention: insights from the Veterans Affairs Clinical Assessment, Reporting, and Tracking (CART) program.

BMC Nephrol 2020 Apr 28;21(1):150. Epub 2020 Apr 28.

Division of Cardiology, Washington University School of Medicine, St. Louis, MO, USA.

Background: Contrast-Associated Acute Kidney Injury (CA-AKI) is a serious complication associated with percutaneous coronary intervention (PCI). Patients with chronic kidney disease (CKD) have an elevated risk for developing this complication. Although CA-AKI prophylactic measures are available, the supporting literature is variable and inconsistent for periprocedural hydration and N-acetylcysteine (NAC), but is stronger for contrast minimization. Read More

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http://dx.doi.org/10.1186/s12882-020-01802-zDOI Listing