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    1665 results match your criteria BMC Nephrology[Journal]

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    Renal Association Clinical Practice Guideline on peritoneal dialysis in adults and children.
    BMC Nephrol 2017 Nov 16;18(1):333. Epub 2017 Nov 16.
    Patient Representative, c/o The Renal Association, Bristol, UK.
    These guidelines cover all aspects of the care of patients who are treated with peritoneal dialysis. This includes equipment and resources, preparation for peritoneal dialysis, and adequacy of dialysis (both in terms of removing waste products and fluid), preventing and treating infections. There is also a section on diagnosis and treatment of encapsulating peritoneal sclerosis, a rare but serious complication of peritoneal dialysis where fibrotic (scar) tissue forms around the intestine. Read More

    The role of the specialized team in the operation of continuous renal replacement therapy: a single-center experience.
    BMC Nephrol 2017 Nov 13;18(1):332. Epub 2017 Nov 13.
    Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
    Background: The requirement of continuous renal replacement therapy (CRRT) is increasing with the growing incidence of acute kidney injury (AKI). The decision to initiate CRRT is not difficult if an adequate medical history is obtained. However, the handling and maintenance of CRRT constitute a labor-intensive intervention that requires specialized skills. Read More

    Evaluating the effectiveness of IV iron dosing for anemia management in common clinical practice: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS).
    BMC Nephrol 2017 Nov 9;18(1):330. Epub 2017 Nov 9.
    Arbor Research Collaborative for Health, 340 E. Huron, Suite 300, Ann Arbor, MI, 48104, USA.
    Background: Anemia management protocols in hemodialysis (HD) units differ conspicuously regarding optimal intravenous (IV) iron dosing; consequently, patients receive markedly different cumulative exposures to IV iron and erythropoiesis-stimulating agents (ESAs). Complementary to IV iron safety studies, our goal was to gain insight into optimal IV iron dosing by estimating the effects of IV iron doses on Hgb, TSAT, ferritin, and ESA dose in common clinical practice.

    Methods: 9,471 HD patients (11 countries, 2009-2011) in the DOPPS, a prospective cohort study, were analyzed. Read More

    Predictive abilities of cardiovascular biomarkers to rapid decline of renal function in Chinese community-dwelling population: a 5-year prospective analysis.
    BMC Nephrol 2017 Nov 9;18(1):331. Epub 2017 Nov 9.
    Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
    Background: Predictive abilities of cardiovascular biomarkers to renal function decline are more significant in Chinese community-dwelling population without glomerular filtration rate (GFR) below 60 ml/min/1.73m(2), and long-term prospective study is an optimal choice to explore this problem. Aim of this analysis was to observe this problem during the follow-up of 5 years. Read More

    The increasing rates of acute interstitial nephritis in Australia: a single centre case series.
    BMC Nephrol 2017 Oct 31;18(1):329. Epub 2017 Oct 31.
    Department of Renal Medicine, Royal Brisbane and Women's Hospital, Herston, QLD, 4029, Australia.
    Background: The Australian Institute of Health and Welfare's first report into acute kidney injury demonstrated a significant increase in the incidence of acute-tubulo interstitial nephritis, the ICD-10 code representing both acute interstitial nephritis and pyelonephritis, in women aged less than 55 years. In contrast, recent case series have reported rising rates of drug induced acute interstitial nephritis predominantly among elderly patients. Due to several limitations with the Australian Institute of Health and Welfare report, this new trend requires further investigation to determine if rates of acute interstitial nephritis are truly increasing among younger Australian women. Read More

    Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation.
    BMC Nephrol 2017 Oct 31;18(1):326. Epub 2017 Oct 31.
    Department of Anatomy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
    Background: Uric acid (UA) plays important roles in inducing renal inflammation, intra-renal vasoconstriction and renal damage. Endothelin-1 (ET-1) is a well-known profibrotic factor in the kidney and is associated with fibroblast expansion. We examined the role of hyperuricemia conditions in causing elevation of ET-1 expression and kidney injury. Read More

    Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity.
    BMC Nephrol 2017 Oct 31;18(1):327. Epub 2017 Oct 31.
    Tohoku University, United Centers for Advanced Research and Translational Medicine, Center for Advanced and Integrated Renal Science, Sendai, Japan.
    Background: Peritoneal dialysis (PD) is used as renal replacement therapy in patients with end-stage kidney disease. However, peritoneal membrane failure remains problematic and constitutes a critical cause of PD discontinuation. Recent studies have revealed the unique biological action of molecular hydrogen (H2) as an anti-oxidant, which ameliorates tissue injury. Read More

    The prevalence and mortality of hyponatremia is seriously underestimated in Chinese general medical patients: an observational retrospective study.
    BMC Nephrol 2017 Oct 31;18(1):328. Epub 2017 Oct 31.
    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Shuaifuyan, Wangfujing St, Beijing, 100730, China.
    Background: Hyponatremia (serum sodium concentration < 135 mmol/L) is the most common electrolyte abnormality and is a predictor of the mortality of hospitalized patients in Western countries. However, hyponatremia data are lacking in Asian countries. Here we evaluate the epidemiology and mortality of hyponatremia in general medical hospitalized patients in China. Read More

    Phenotype variability in a large Spanish family with Alport syndrome associated with novel mutations in COL4A3 gene.
    BMC Nephrol 2017 Oct 31;18(1):325. Epub 2017 Oct 31.
    Molecular Diagnostics Unit, Center for Biomedical Research (CIBIR), Fundación Rioja Salud, C/Piqueras 98, 26006, Logroño, La Rioja, Spain.
    Background: Alport syndrome is an inherited renal disorder characterized by glomerular basement membrane lesions with hematuria, proteinuria and frequent hearing defects and ocular abnormalities. The disease is associated with mutations in genes encoding α3, α4, or α5 chains of type IV collagen, namely COL4A3 and COL4A4 in chromosome 2 and COL4A5 in chromosome X. In contrast to the well-known X-linked and autosomal recessive phenotypes, there is very little information about the autosomal dominant. Read More

    Differential diagnosis of thrombotic microangiopathy in nephrology.
    BMC Nephrol 2017 Oct 28;18(1):324. Epub 2017 Oct 28.
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
    Background: The differential diagnosis of thrombotic microangiopathy (TMA) is complex however the rapid diagnosis of the underlying condition is vital to inform urgent treatment decisions. A survey was devised with the objective of understanding current practices across Europe and the Middle East, and of challenges when diagnosing the cause of TMA.

    Methods: Over 450 clinicians, from 16 countries were invited to complete an online survey. Read More

    Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency.
    BMC Nephrol 2017 Oct 27;18(1):323. Epub 2017 Oct 27.
    Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
    Background: We studied whether endothelin receptor antagonist and calcimimetic treatments influence renal damage and kidney renin-angiotensin (RA) components in adenine-induced chronic renal insufficiency (CRI).

    Methods: Male Wistar rats (n = 80) were divided into 5 groups for 12 weeks: control (n = 12), 0.3% adenine (Ade; n = 20), Ade + 50 mg/kg/day sitaxentan (n = 16), Ade + 20 mg/kg/day cinacalcet (n = 16), and Ade + sitaxentan + cinacalcet (n = 16). Read More

    Care of the dialysis patient: Primary provider involvement and resource utilization patterns - a cohort study.
    BMC Nephrol 2017 Oct 25;18(1):322. Epub 2017 Oct 25.
    Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
    Background: Efficient and safe delivery of care to dialysis patients is essential. Concerns have been raised regarding the ability of accountable care organizations to adequately serve this high-risk population. Little is known about primary care involvement in the care of dialysis patients. Read More

    Patient's and physician's awareness of kidney disease in coronary heart disease patients - a cross-sectional analysis of the German subset of the EUROASPIRE IV survey.
    BMC Nephrol 2017 Oct 25;18(1):321. Epub 2017 Oct 25.
    Institute of Clinical Epidemiology and Biometry, University of Würzburg, Petrinistr. 33a, 97080, Würzburg, Germany.
    Background: Chronic kidney disease (CKD) is a common comorbid condition in coronary heart disease (CHD). CKD predisposes the patient to acute kidney injury (AKI) during hospitalization. Data on awareness of kidney dysfunction among CHD patients and their treating physicians are lacking. Read More

    Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1.
    BMC Nephrol 2017 Oct 24;18(1):320. Epub 2017 Oct 24.
    Department of Translational Medicine, Clinical Pathology, Lund University, SUS Malmö, Jan Waldenströms gata 59, SE-20502, Malmö, Sweden.
    Background: Caveolae are membrane invaginations measuring 50-100 nm. These organelles, composed of caveolin and cavin proteins, are important for cellular signaling and survival. Caveolae play incompletely defined roles in human kidneys. Read More

    Intensive procedure preferences at the end of life (EOL) in older Latino adults with end stage renal disease (ESRD) on dialysis.
    BMC Nephrol 2017 Oct 23;18(1):319. Epub 2017 Oct 23.
    Division of General Internal Medicine, University of California, Davis School of Medicine, 4150 V Street, Suite 2400, Sacramento, CA, 95817, USA.
    Background: Latinos in the U.S. are almost twice as likely to progress to End Stage Renal disease (ESRD) compared to non-Latino whites. Read More

    An integrative review of the methodology and findings regarding dietary adherence in end stage kidney disease.
    BMC Nephrol 2017 Oct 23;18(1):318. Epub 2017 Oct 23.
    School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Northfields Ave, Wollongong, New South Wales, 2522, Australia.
    Background: Dietary modification is an important component of the management of end stage kidney disease (ESKD). The diet for ESKD involves modifying energy and protein intake, and altering sodium, phosphate, potassium and fluid intake. There have been no comprehensive reviews to date on this topic. Read More

    Hospital acquired Acute Kidney Injury is associated with increased mortality but not increased readmission rates in a UK acute hospital.
    BMC Nephrol 2017 Oct 20;18(1):317. Epub 2017 Oct 20.
    University Hospitals Birmingham, Birmingham, UK.
    Background: Acute Kidney Injury (AKI) has evoked much interest over the past decade and is reported to be associated with high inpatient mortality. Preventable death and increased readmission rates related to AKI have been the focus of considerable interest.

    Methods: We studied hospital acquired AKI in all emergency hospital admissions, except transfers from ICU to ICU or patients known to renal services, to ascertain mortality and readmission rates, and trackable modifiable factors for death, using cox regression and Kaplan Meier survival curves. Read More

    A low initial serum sodium level is associated with an increased risk of overcorrection in patients with chronic profound hyponatremia: a retrospective cohort analysis.
    BMC Nephrol 2017 Oct 18;18(1):316. Epub 2017 Oct 18.
    Department of Nephrology, St. Luke's International Hospital, Tokyo, Japan.
    Background: Even with abundant evidence for osmotic demyelination in patients with hyponatremia, the risk factors for overcorrection have not been fully investigated. Therefore the purpose of this study is to clarify the risks for overcorrection during the treatment of chronic profound hyponatremia.

    Methods: This is a single-center retrospective observational study. Read More

    The use of cinacalcet hinders the diagnosis of parathyroid carcinoma in a chronic dialysis patient: a case report.
    BMC Nephrol 2017 Oct 18;18(1):315. Epub 2017 Oct 18.
    Department of Nephrology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo, Kyoto, Japan.
    Background: Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving chronic dialysis therapy. Although cinacalcet can control parathyroid function and bone turnover, preventing ectopic calcification remains challenging. Cinacalcet can also suppress PTH secretion due to parathyroid carcinoma in the same way as it does for parathyroid hyperplasia in the uremic condition. Read More

    Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models.
    BMC Nephrol 2017 Oct 18;18(1):314. Epub 2017 Oct 18.
    Department of Nephrology Guizhou Provincial People's Hospital, Guiyang, 550002, China.
    Background: Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular interstitial fibrosis (CRTIF) are poorly known. This study aimed to examine the effects of Tβ4 on the renal apoptosis and the expression of transforming growth factor (TGF-β), E-cadherin, and α-smooth muscle actin (α-SMA) in CRTIF rat models.

    Methods: Male SD rats were randomized into four groups (sham group, unilateral ureteral obstruction (UUO) group, UUO + low-dose Tβ4 group, and UUO + high-dose Tβ4 group). Read More

    Bowel perforation by a peritoneal dialysis catheter: report of two cases.
    BMC Nephrol 2017 Oct 16;18(1):312. Epub 2017 Oct 16.
    Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Background: Complications of peritoneal dialysis (PD) such as pain and catheter leakage are frequently reported. Delayed bowel perforation of a PD catheter is a rare adverse event but a serious complication associated with significant mortality. Bowel perforation of a PD catheter is difficult to differentiate from PD-related peritonitis and likely to result in a delay in diagnosis. Read More

    Clinical features and CKD-related quality of life in patients with CKD G3a and CKD G3b in China: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE).
    BMC Nephrol 2017 Oct 13;18(1):311. Epub 2017 Oct 13.
    Department of Nephrology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
    Background: This study aimed to compare clinical features and health-related quality of life (HRQoL) in the Chinese chronic kidney disease (CKD) 3 population and determined the necessity of the subdivision of CKD3 in Chinese patients with CKD.

    Methods: Participants with stage 3 CKD (18-74 years of age) were recruited at 39 clinical centers located at 28 cities in 22 provinces of China. The sociodemographic status, medical history, anthropometric measurements, and lifestyle behaviors were documented at entry, and blood and urine samples were collected. Read More

    Difficult conversations: Australian Indigenous patients' views on kidney transplantation.
    BMC Nephrol 2017 Oct 11;18(1):310. Epub 2017 Oct 11.
    Menzies School of Health Research, Darwin, Australia.
    Background: Indigenous Australians suffer a disproportionate burden of end stage kidney disease (ESKD) but are significantly less likely to receive a transplant. This study explores Indigenous ESKD patients' views on transplantation as a treatment option.

    Methods: The Improving Access to Kidney Transplants (IMPAKT) research program investigated barriers to kidney transplantation for Indigenous Australians. Read More

    Frequency of arrhythmia symptoms and acceptability of implantable cardiac monitors in Hemodialysis patients.
    BMC Nephrol 2017 Oct 10;18(1):309. Epub 2017 Oct 10.
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, 301 Mason Lord Drive, Suite 2500, Baltimore, MD, 21224-2780, USA.
    Background: Arrhythmia-related complications and sudden death are common in dialysis patients. However, routine cardiac monitoring has so far not been feasible. Miniaturization of implantable cardiac monitors offers a new paradigm for detection and management of arrhythmias in dialysis patients. Read More


    Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression.
    BMC Nephrol 2017 Oct 4;18(1):307. Epub 2017 Oct 4.
    Department of Nephrology, the Affiliated Hospital of Taishan Medical University, No. 706 Taishan Street, Taian, Shandong Province, 271000, China.
    Background: This study aimed to investigate the effects of benazepril hydrochloride (BH) on proteinuria and ANGPTL-4 expression in a diabetic nephropathy (DN) rat model.

    Methods: A total of 72 Wistar male rats were randomly divided into three groups: normal control (NC), DN group and BH treatment (BH) groups. The DN model was induced by streptozotocin (STZ). Read More

    Pathogenic role of glycan-specific IgG antibodies in IgA nephropathy.
    BMC Nephrol 2017 Sep 29;18(1):301. Epub 2017 Sep 29.
    Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
    Background: Accumulating evidences proved the important roles of circulating IgA1-containing immune complexes (cIgA1) in IgA nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) and glycan-specific IgG antibody have been identified as major components in cIgA1. Before, Gd-IgA1 was reported as a vital factor in IgAN, partly via of its pathogenic role to induce mesangial cells activation. Read More

    Renal transplant patients' preference for the supply and delivery of immunosuppressants in Wales: a discrete choice experiment.
    BMC Nephrol 2017 Oct 2;18(1):305. Epub 2017 Oct 2.
    Centre for Health Economics and Medicines Evaluation, Bangor University, Ardudwy, Holyhead Road, Bangor, Wales, LL57 2PZ, UK.
    Background: Prescribing policy recommendations aimed at moving immunosuppressant prescribing for renal transplant patients from primary to secondary care may result in benefits of increased safety and reduced cost. However, there is little evidence of patients' preferences for receiving their immunosuppressant therapy from hospitals compared to community dispensing. The aim of this study was to elicit patient preferences for different service configurations focusing in particular on home delivery versus collection of medication from hospital. Read More

    The effect of regional citrate anti-coagulation on the coagulation system in critically ill patients receiving continuous renal replacement therapy for acute kidney injury - an observational cohort study.
    BMC Nephrol 2017 Oct 2;18(1):304. Epub 2017 Oct 2.
    King's College London, Guy's & St Thomas' NHS Foundation Trust, Department of Critical Care, London, SE1 9RT, UK.
    Background: Regional anticoagulation with citrate is the recommended first line treatment for patients receiving continuous renal replacement therapy (CRRT). There is wide variability in filter patency which may be due to differences in patient characteristics and local practice. It is also possible that citrate has effects on primary and secondary haemostasis, fibrinolysis and platelet function that are still unknown. Read More

    Identification of compound heterozygous patients with primary hyperoxaluria type 1: clinical evaluations and in silico investigations.
    BMC Nephrol 2017 Oct 2;18(1):303. Epub 2017 Oct 2.
    Laboratoire de Génétique Moléculaire Humaine, Faculté de Médecine de Sfax, Université de Sfax, Sfax, Tunisie.
    Background: Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inherited disorder of glyoxylate metabolism in which excessive oxalates are formed by the liver and excreted by the kidneys. Calcium oxalate crystallizes in the urine, leading to urolithiasis, nephrocalcinosis, and consequent renal failure if treatment is not initiated promptly. Mutations in the AGXT gene which encodes the hepatic peroxisomal enzyme alanine:glyoxylate aminotransferase are responsible of PH1. Read More

    Validity and reliability of the Urdu version of the 5D itching scale to assess pruritus among patients with chronic kidney disease in Pakistan.
    BMC Nephrol 2017 Oct 2;18(1):302. Epub 2017 Oct 2.
    School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, Malaysia.
    Background: Chronic kidney disease (CKD) has become a major public health issue worldwide in the past few years. Pruritus is a common, well-recognized complication often seen in patients with chronic renal failure. For assessment of pruritus, different tools are used but these tools are unable to identify the changes and variations in the severity of pruritus. Read More

    Diagnostic challenge in a patient with nephropathic juvenile cystinosis: a case report.
    BMC Nephrol 2017 Sep 26;18(1):300. Epub 2017 Sep 26.
    Department of Pediatrics, Yokohama City University, Graduate School of Medicine, Yokohama, Kanagawa, Japan.
    Background: Cystinosis is a rare autosomal recessive lysosomal disorder characterized by the accumulation of cystine in lysosomes. Cystinosis is much rarer in Asian than Caucasian populations. There are only 14 patients have with cystinosis alive in Japan. Read More

    Increased prevalence of renal cysts in patients with sickle cell disease.
    BMC Nephrol 2017 Sep 21;18(1):298. Epub 2017 Sep 21.
    Department of Renal Sciences, Division of Transplantation Immunology and Mucosal Biology, Faculty of Life Sciences and Medicine, King's College London, London, SE5 9RJ, UK.
    Background: Early detection and interventions have enabled patients with sickle cell disease (SCD) to live well into adulthood. Consequently, the chronicity of SCD allows for the insidious manifestation of multisystem complications, including renal damage. Cystic renal lesions are commonly incidentally discovered on ultrasound and computerised tomography (CT) imaging of the abdomen. Read More

    Transitional cell carcinoma involving graft kidney in a kidney transplant recipient: a case report.
    BMC Nephrol 2017 Sep 21;18(1):299. Epub 2017 Sep 21.
    Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Daejeon St. Mary's Hospital 64, Daeheung-ro, Jung-gu, Daejeon, 34943, Republic of Korea.
    Background: Kidney transplantation (KT) is the treatment option for patients with end stage renal disease (ESRD) to prolong survival and improve quality of life. Although the use of potent immunosuppressive agents increases graft survival in kidney transplantation recipients (KTRs), it may lead to the development of malignancy, including transitional cell carcinoma (TCC). TCC developing in the pelvis of graft kidney is very rare in KTRs. Read More

    Lifestyle intervention to improve quality of life and prevent weight gain after renal transplantation: Design of the Active Care after Transplantation (ACT) randomized controlled trial.
    BMC Nephrol 2017 Sep 15;18(1):296. Epub 2017 Sep 15.
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
    Background: Low physical activity and reduced physical functioning are common after renal transplantation, resulting in a reduced quality of life. Another common post-transplantation complication is poor cardio-metabolic health, which plays a main role in long-term outcomes in renal transplant recipients (RTR). It is increasingly recognized that weight gain in the first year after transplantation, especially an increase in fat mass, is a highly common contributor to cardio-metabolic risk. Read More

    Validity and reproducibility of a short food frequency questionnaire among patients with chronic kidney disease.
    BMC Nephrol 2017 Sep 15;18(1):297. Epub 2017 Sep 15.
    Inserm U1018, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France.
    Background: A balanced diet is essential to slowing the progression of chronic kidney disease (CKD) and managing the symptoms. Currently, no tool is available to easily and quickly assess energy and macronutrient intake in patients with non end-stage CKD. We aimed to develop and evaluate the validity and reproducibility of a new short 49-item food frequency questionnaire (SFFQ) adapted to patients with CKD. Read More

    Association of plasma potassium with mortality and end-stage kidney disease in patients with chronic kidney disease under nephrologist care - The NephroTest study.
    BMC Nephrol 2017 Sep 12;18(1):295. Epub 2017 Sep 12.
    FCRIN INI-CRCT, Paris, France.
    Background: Low and high blood potassium levels are common and were both associated with poor outcomes in patients with chronic kidney disease (CKD). Whether such relationships may be altered in CKD patients receiving optimized nephrologist care is unknown.

    Methods: NephroTest is a hospital-based prospective cohort study that enrolled 2078 nondialysis patients (mean age: 59 ± 15 years, 66% men) in CKD stages 1 to 5 who underwent repeated extensive renal tests including plasma potassium (PK) and glomerular filtration rate (GFR) measured (mGFR) by (51)Cr-EDTA renal clearance. Read More

    Efficacy of blood flow restriction exercise during dialysis for end stage kidney disease patients: protocol of a randomised controlled trial.
    BMC Nephrol 2017 Sep 11;18(1):294. Epub 2017 Sep 11.
    Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, 3125, Australia.
    Background: Exercise during haemodialysis improves strength and physical function. However, both patients and clinicians are time poor, and current exercise recommendations add an excessive time burden making exercise a rare addition to standard care. Hypothetically, blood flow restriction exercise performed during haemodialysis can provide greater value for time spent exercising, reducing this time burden while producing similar or greater outcomes. Read More

    Factors associated with foot ulceration and amputation in adults on dialysis: a cross-sectional observational study.
    BMC Nephrol 2017 Sep 8;18(1):293. Epub 2017 Sep 8.
    Discipline of Podiatry, School of Allied Health, La Trobe University, Melbourne, VIC, 3086, Australia.
    Background: Adults on dialysis are at increased risk of foot ulceration, which commonly precedes more serious lower limb complications, including amputation. Limited data exist regarding the prevalence and factors associated with foot disease in this population. Hence, this study set out to investigate factors associated with foot ulceration and amputation in a dialysis cohort. Read More

    Predictors of Acute Renal Injury Study (PARIS) among HIV-positive individuals: design and methods.
    BMC Nephrol 2017 Sep 7;18(1):289. Epub 2017 Sep 7.
    San Francisco and San Francisco VA Health Care System, Kidney Health Research Collaborative, University of California, 1450 Clement St., 111A1, San Francisco, 94121, CA, USA.
    Background: Acute kidney injury (AKI), which is common among HIV-positive individuals, may contribute to the excess burden of chronic kidney disease (CKD) in this patient population; however, conventional clinical methods to detect AKI do not capture kidney injury sufficiently early to prevent irreversible damage. Further, large observational and interventional studies of AKI generally exclude HIV-positive persons in spite of their disproportionate risk.

    Methods: The Predictors of Acute Renal Injury Study (PARIS) is a prospective observational cohort study among HIV-positive individuals established to determine the ability of candidate kidney injury biomarkers to predict future hospitalized clinical AKI, to characterize hospitalized subclinical AKI, and to discern the risk of progressive kidney disease following subclinical and clinical AKI. Read More

    Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure.
    BMC Nephrol 2017 Sep 7;18(1):291. Epub 2017 Sep 7.
    Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
    Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. Read More

    Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells.
    BMC Nephrol 2017 Sep 7;18(1):292. Epub 2017 Sep 7.
    Division of Nephrology, University of Utah Health Sciences Center, 1900 E 30 N, Salt Lake City, UT, 84132, USA.
    Background: The distal convoluted tubule (DCT) is an important nephron site for parathyroid hormone (PTH) and calcitonin regulation of urinary divalent cation excretion. These hormones exert their effects on the DCT in substantial part through activation of adenylyl cyclase (AC); however, it is unknown which AC isoforms are involved.

    Methods: To examine this, two mouse DCT cell lines were studied: 209 and D1 cells. Read More

    Serum osteoprotegerin in prevalent hemodialysis patients: associations with mortality, atherosclerosis and cardiac function.
    BMC Nephrol 2017 Sep 7;18(1):290. Epub 2017 Sep 7.
    Nephrology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS, Barcelona, Spain.
    Background: To assess whether serum osteoprotegerin (OPG) and/or fetuin-A predict mortality and cardiovascular (CV) morbidity and mortality in hemodialysis patients.

    Methods: Multicenter, observational, prospective study that included 220 hemodialysis patients followed up for up to 6 years. Serum OPG and fetuin-A levels were measured at baseline and their possible association with clinical characteristics, CV risk biomarkers, carotid ultrasonographic findings, as well as their association with overall and CV mortality and CV events were assessed. Read More

    Fibronectin glomerulopathy complicated with persistent cloaca and congenital esophageal atresia: a case report and literature review.
    BMC Nephrol 2017 Sep 6;18(1):288. Epub 2017 Sep 6.
    Kidney Unit, National Fukuoka-Higashi Medical Center, Fukuoka, Japan.
    Background: Fibronectin glomerulopathy is a rare, inherited, autosomal dominant, glomerular disease characterized by proteinuria, microscopic hematuria, hypertension, massive glomerular deposits of fibronectin, and slow progression to end-stage renal failure. Because the incident of fibronectin glomerulopathy is extremely low, the pathophysiology, genetic abnormalities, epidemiology, and mechanisms remain to be elucidated.

    Case Presentation: We report a 21-year-old woman with fibronectin glomerulopathy, who had been diagnosed with persistent cloaca and congenital esophageal atresia at birth. Read More

    Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition.
    BMC Nephrol 2017 Sep 6;18(1):287. Epub 2017 Sep 6.
    Postgraduate Program in Medicine, Universidade Nove de Julho (UNINOVE), Rua Vergueiro, 235, 2º subsolo, São Paulo, 01504-001, São Paulo, Brazil.
    Background: Indoleamine 2, 3-dioxygenase (IDO) is an immunomodulatory molecule that has been implicated in several biological processes. Although IDO has been linked with some renal diseases, its role in renal fibrosis is still unclear. Because IDO may be modulated by TGF-β1, a potent fibrogenic molecule, we hypothesized that IDO could be involved in renal fibrosis, especially acting in the TGF-β1-induced tubular epithelial-mesenchymal transition (EMT). Read More

    Bone turnover markers are associated with bone density, but not with fracture in end stage kidney disease: a cross-sectional study.
    BMC Nephrol 2017 Sep 6;18(1):284. Epub 2017 Sep 6.
    Department of Renal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.
    Background: Fracture risk is increased in chronic kidney disease (CKD), but assessment of bone fragility remains controversial in these patients. This study investigated the associations between bone turnover markers, bone mineral density (BMD), and prevalent fragility fracture in a cohort of kidney transplantation candidates.

    Methods: Volumetric BMD of spine and hip was measured by quantitative computed tomography. Read More

    A chronic hemodialysis patient with isolated pulmonary valve infective endocarditis caused by non-albicans Candida: a rare case and literature review.
    BMC Nephrol 2017 Sep 6;18(1):286. Epub 2017 Sep 6.
    Department of Internal Medicine, Cardinal Tien Hospital An-Kang branch, School of Medicine, Fu-Jen Catholic University, No. 15, Chezi Road., Hsin-Tien District, New Taipei City, 23155, Taiwan, Republic of China.
    Background: Isolated pulmonary valve infective endocarditis caused by Candida is rare in chronic hemodialysis patients. The 2009 Infectious Diseases Society of America guidelines suggest the combined use of surgery and antibiotics to treat candidiasis; however, successful nonsurgical treatment of Candida endocarditis has been reported.

    Case Presentation: A 63-year-old woman with end-stage kidney disease was admitted to our hospital after experiencing disorientation for 5 days. Read More

    Doxycycline treatment in dialysis related amyloidosis: discrepancy between antalgic effect and inflammation, studied with FDG-positron emission tomography: a case report.
    BMC Nephrol 2017 Sep 6;18(1):285. Epub 2017 Sep 6.
    Nuclear Medicine Centre Hospitalier Le Mans, 72000, Le Mans, France.
    Background: No effective treatment is currently available and dialysis related amyloidosis continues to be invalidating in long-term dialysis patients. A recent case series reported reduction of osteoarticular pain on doxycycline treatment, extending the indications of this drug, used in other uncommon forms of amyloidosis, to dialysis patients. Explanations of the antalgic effect were the anti-inflammatory properties and anti-coiling effects of tetracycline. Read More

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