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    Prevalence and correlates of non-adherence to immunosuppressants and to health behaviours in patients after kidney transplantation in Brazil - the ADHERE BRAZIL multicentre study: a cross-sectional study protocol.
    BMC Nephrol 2018 Feb 20;19(1):41. Epub 2018 Feb 20.
    Hospital do Rim e Hipertensão, Federal University of São Paulo, São Paulo, Brazil.
    Background: Non-adherence to immunosuppressive therapy is a prevalent risk factor for poor clinical and after kidney transplantation (KT), and has contributed to the lack of improvement in long-term graft survival over the past decade. Understanding the multilevel correlates and risk factors of non-adherence is crucial to determine the optimal level for planning interventions, namely at the patient, health care provider, KT centre, and health care system level. Brazil, having the largest public transplantation program in the world and with regional differences regarding access to health services and service implementation, is in a unique position to study this multilevel approach. Read More

    Comparison of visceral, body fat indices and anthropometric measures in relation to chronic kidney disease among Chinese adults from a large scale cross-sectional study.
    BMC Nephrol 2018 Feb 17;19(1):40. Epub 2018 Feb 17.
    Fuwai Hospital, Pecking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100037, China.
    Background: The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat index (VFI), percentage body fat (PBF), body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR).

    Methods: A total of 29,516 participants aged 35 years or above were selected using a stratified multistage random sampling method across China during 2012-2015. CKD was defined as an estimated glomerular filtration (eGFR) < 60 ml/min/1. Read More

    Establishing a clinical phenotype for cachexia in end stage kidney disease - study protocol.
    BMC Nephrol 2018 Feb 13;19(1):38. Epub 2018 Feb 13.
    School of Medicine, Dentistry and Biomedical Sciences, Queens University Belfast and Regional Nephrology Unit, Belfast City Hospital, Belfast HSC Trust, Belfast, UK.
    Background: Surveys using traditional measures of nutritional status indicate that muscle wasting is common among persons with end-stage kidney disease (ESKD). Up to 75% of adults undergoing maintenance dialysis show some evidence of muscle wasting. ESKD is associated with an increase in inflammatory cytokines and can result in cachexia, with the loss of muscle and fat stores. Read More

    Renal manifestations of tuberous sclerosis complex: patients' and parents' knowledge and routines for renal follow-up - a questionnaire study.
    BMC Nephrol 2018 Feb 13;19(1):39. Epub 2018 Feb 13.
    Department of Urinary and Vascular Imaging, Hôpital Edouard Herriot, Lyon, France.
    Background: Renal angiomyolipomas (AMLs) are a major clinical feature in patients with tuberous sclerosis complex (TSC). Spontaneous bleeding can be life threatening, and appropriate information and proper surveillance and management are important to limit morbidity and mortality. Because TSC is a rare disease, patients are at risk of suboptimal medical management. Read More

    A model to predict disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD): the ADPKD Outcomes Model.
    BMC Nephrol 2018 Feb 13;19(1):37. Epub 2018 Feb 13.
    Otsuka Pharmaceutical Europe Ltd, Gallions Wexham Springs, Framewood Road, Wexham, SL3 6PJ, UK.
    Background: Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients. This study aimed to develop a natural history model of ADPKD that predicted progression rates and long-term outcomes in patients with differing baseline characteristics.

    Methods: The ADPKD Outcomes Model (ADPKD-OM) was developed using available patient-level data from the placebo arm of the Tolvaptan Efficacy and Safety in Management of ADPKD and its Outcomes Study (TEMPO 3:4; ClinicalTrials. Read More

    The COMT-polymorphism is not associated with the incidence of acute kidney injury after cardiac surgery - a prospective cohort study.
    BMC Nephrol 2018 02 9;19(1):34. Epub 2018 Feb 9.
    Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
    Background: The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Recent studies suggest that the COMT rs4680 polymorphism is associated with the response to endogenous and exogenous catecholamines. There are, however, conflicting data regarding the COMT Met/Met phenotype being associated with an increased risk of acute kidney injury (AKI) after cardiac surgery. Read More

    Effect of calcitriol on serum hepcidin in individuals with chronic kidney disease: a randomized controlled trial.
    BMC Nephrol 2018 02 9;19(1):35. Epub 2018 Feb 9.
    Departments of Medicine, University of Alabama at Birmingham, ZRB 522, 1720 2nd AVE S, Birmingham, AL, 35294-0006, USA.
    Background: Anemia is highly prevalent in chronic kidney disease (CKD). Elevated hepcidin concentrations are an important mediator of disordered iron metabolism, a key mechanism underlying anemia of CKD. Vitamin D was recently shown to reduce serum hepcidin concentrations in healthy individuals. Read More

    Albuminuria, serum creatinine, and estimated glomerular filtration rate as predictors of cardio-renal outcomes in patients with type 2 diabetes mellitus and kidney disease: a systematic literature review.
    BMC Nephrol 2018 02 9;19(1):36. Epub 2018 Feb 9.
    AbbVie, Chicago, IL, USA.
    Background: Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are pivotal indicators of kidney decline. Yet, it is uncertain if these and emerging biomarkers such as uric acid represent independent predictors of kidney disease progression or subsequent outcomes among individuals with type 2 diabetes mellitus (T2DM). This study systematically examined the available literature documenting the role of albuminuria, serum creatinine, eGFR, and uric acid in predicting kidney disease progression and cardio-renal outcomes in persons with T2DM. Read More

    Blood oxygen level dependent magnetic resonance imaging for detecting pathological patterns in lupus nephritis patients: a preliminary study using a decision tree model.
    BMC Nephrol 2018 02 9;19(1):33. Epub 2018 Feb 9.
    Department of Nephrology, Tianjin Medical University General Hospital, No.154, Anshan Road, Heping District, Tianjin, People's Republic of China.
    Background: Precise renal histopathological diagnosis will guide therapy strategy in patients with lupus nephritis. Blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) has been applicable noninvasive technique in renal disease. This current study was performed to explore whether BOLD MRI could contribute to diagnose renal pathological pattern. Read More

    Influence of vitamin D receptor polymorphisms on biochemical markers of mineral bone disorders in South African patients with chronic kidney disease.
    BMC Nephrol 2018 02 7;19(1):30. Epub 2018 Feb 7.
    Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Background: It remains unclear whether genetic factors may explain the reported variation in the levels of biochemical markers of chronic kidney disease mineral and bone disorders (CKD- MBD) across ethnic groups. Therefore, the aim of this study was to examine the influence of vitamin D receptor (VDR) polymorphisms on secondary hyperparathyroidism and its association with vitamin D levels in black and white South African study participants.

    Methods: This was a cross sectional study involving 272 CKD stage 3- 5D patients and 90 healthy controls. Read More

    Gender-related differences in clinicopathological characteristics and renal outcomes of Chinese patients with IgA nephropathy.
    BMC Nephrol 2018 02 7;19(1):31. Epub 2018 Feb 7.
    Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, Guangzhou, Guangdong, 510080, China.
    Background: The prognostic effect of gender on immunoglobulin A nephropathy (IgAN) is not clear. We explored gender-related differences in clinicopathological features and renal outcomes in IgAN.

    Methods: This was a single-centre retrospective study. Read More

    The impact of disease severity on paradoxical association between body mass index and mortality in patients with acute kidney injury undergoing continuous renal replacement therapy.
    BMC Nephrol 2018 02 7;19(1):32. Epub 2018 Feb 7.
    Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-Gu, Seoul, 03722, South Korea.
    Background: Association between high body mass index (BMI) and survival benefit is confounded by comorbid conditions such as nutritional status and inflammation. Patients with acute kidney injury (AKI), particularly those receiving continuous renal replacement therapy (CRRT), are highly catabolic and more susceptible to loss of energy. Herein, we evaluated whether disease severity can modify the relationship between BMI and mortality. Read More

    MORG1mice are protected from histological renal damage and inflammation in a murine model of endotoxemia.
    BMC Nephrol 2018 02 5;19(1):29. Epub 2018 Feb 5.
    Department of Internal Medicine III, Jena University Hospital, Am Klinikum 1, D-07740, Jena, Germany.
    Background: The MAPK-organizer 1 (MORG1) play a scaffold function in the MAPK and/or the PHD3 signalling paths. Recently, we reported that MORG1mice are protected from renal injury induced by systemic hypoxia and acute renal ischemia-reperfusion injury via increased hypoxia-inducible factors (HIFs). Here, we explore whether MORG1 heterozygosity could attenuate renal injury in a murine model of lipopolysaccharide (LPS) induced endotoxemia. Read More

    Evaluating the prevalence and opportunity for technology use in chronic kidney disease patients: a cross-sectional study.
    BMC Nephrol 2018 02 2;19(1):28. Epub 2018 Feb 2.
    School of Nursing, Queensland University of Technology, Brisbane, Australia.
    Background: Chronic kidney disease (CKD) is increasing worldwide and early education to improve adherence to self-management is a key strategy to slow CKD progression. The use of the internet and mobile phone technologies (mHealth) to support patients is considered an effective tool in many other chronic disease populations. While a number of mHealth platforms for CKD exist, few studies have investigated if and how this population use technology to engage in self-management. Read More

    Quantification of cancer risk in glomerulonephritis.
    BMC Nephrol 2018 02 2;19(1):27. Epub 2018 Feb 2.
    Department of Production, Research and Innovation, Region Zealand, Sorø, Denmark.
    Background: The association of increased cancer risk with glomerulonephritis (GN) is well known, but controversy exists concerning which types of GN are involved, and the size of the association. A national registry survey was performed to assess the size of this association, and the temporal relationship of cancer diagnosis to GN diagnosis.

    Methods: All patients with biopsy-proven GN between 1985 and 2015 in Denmark were extracted from The Danish Renal Biopsy Registry and the National Pathology Data Bank. Read More

    Incidence, aetiology and outcomes of obstetric-related acute kidney injury in Malawi: a prospective observational study.
    BMC Nephrol 2018 02 2;19(1):25. Epub 2018 Feb 2.
    Department of Internal Medicine, Queen Elizabeth Central Hospital, Blantyre, Malawi.
    Background: Obstetric-related acute kidney injury (AKI) is thought to be a key contributor to the overall burden of AKI in low resource settings, causing significant and preventable morbidity and mortality. However, epidemiological data to corroborate these hypotheses is sparse. This prospective observational study aims to determine the incidence, aetiology and maternal-fetal outcomes of obstetric-related AKI in Malawi. Read More

    Cortical and trabecular bone are equally affected in rats with renal failure and secondary hyperparathyroidism.
    BMC Nephrol 2018 02 2;19(1):24. Epub 2018 Feb 2.
    Musculoskeletal Disease Center, VA Loma Linda Healthcare System, 11201 Benton Street, Loma Linda, CA, 92357, USA.
    Background: Changes in mineral metabolism and bone structure develop early in the course of chronic kidney disease and at end-stage are associated with increased risk of fragility fractures. The disruption of phosphorus homeostasis leads to secondary hyperparathyroidism, a common complication of chronic kidney disease. However, the molecular pathways by which high phosphorus influences bone metabolism in the early stages of the disease are not completely understood. Read More

    Contiguous 22.1-kb deletion embracing AVPR2 and ARHGAP4 genes at novel breakpoints leads to nephrogenic diabetes insipidus in a Chinese pedigree.
    BMC Nephrol 2018 02 2;19(1):26. Epub 2018 Feb 2.
    Genetics and Prenatal Diagnosis Center, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road East, Zhengzhou, Henan, 450052, China.
    Background: It has been reported that mutations in arginine vasopressin type 2 receptor (AVPR2) cause congenital X-linked nephrogenic diabetes insipidus (NDI). However, only a few cases of AVPR2 deletion have been documented in China.

    Methods: An NDI pedigree was included in this study, including the proband and his mother. Read More

    Existing creatinine-based equations overestimate glomerular filtration rate in Indians.
    BMC Nephrol 2018 02 1;19(1):22. Epub 2018 Feb 1.
    Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correction factors in the originally developed creatinine-based GFR estimation equations for populations around the world. Existing equations have not been validated in the vegetarian Indian population. Read More

    Perioperative risk assessment for successful kidney transplant in leigh syndrome: a case report.
    BMC Nephrol 2018 02 1;19(1):23. Epub 2018 Feb 1.
    Department of Renal Medicine, Eastern Health Clinical School, Monash University, Level 2, 5 Arnold Street, Box Hill, Clayton, VIC, Australia.
    Background: Leigh syndrome (LS) is a rare neurodegenerative mitochondrial disorder which typically presents in childhood but has a varied clinical course. Renal involvement such as proximal tubulopathy in patients with mitochondrial disorders has been described. However, end stage renal disease (ESRD) is uncommon and literature regarding patients undergoing kidney transplantation is limited. Read More

    Proteinuric kidney disease in children at Queen Elizabeth Central Hospital, Malawi.
    BMC Nephrol 2018 01 31;19(1):21. Epub 2018 Jan 31.
    Renal Department, Barts Health NHS Trust, London, UK.
    Background: There is a paucity of data on paediatric kidney disease in developing countries such as Malawi. Descriptive research on kidney disease is essential to improving patient outcomes.

    Methods: We conducted a cross-sectional study at a tertiary hospital in Malawi from 2012 to 2013. Read More

    Leptospirosis presenting as haemolytic uraemic syndrome: a case report.
    BMC Nephrol 2018 01 29;19(1):20. Epub 2018 Jan 29.
    Department of Renal Medicine and Transplantation, The Royal London Hospital, Barts Health NHS Trust, London, UK.
    Background: Leptospirosis is a rare infectious disease especially in Western Countries. Renal involvement is a recognised complication of leptospirosis but leptospirosis-associated haemolytic uraemic syndrome is extremely rare and to our knowledge has only been reported once, in 1985.

    Case Presentation: A 29-year-old male was transferred to our Renal Unit with fevers, myalgia and diarrhoeal illness. Read More

    Epoetin beta pegol for treatment of anemia ameliorates deterioration of erythrocyte quality associated with chronic kidney disease.
    BMC Nephrol 2018 01 27;19(1):19. Epub 2018 Jan 27.
    Product Research Department, Chugai Pharmaceutical Co., Ltd, 200 Kajiwara, Kamakura, 247-8530, Japan.
    Background: Epoetin beta pegol (continuous erythropoietin receptor activator; C.E.R. Read More

    Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism.
    BMC Nephrol 2018 01 27;19(1):17. Epub 2018 Jan 27.
    Departments of Pediatrics, Vanderbilt University Medical Center, 1161 21st Avenue South, C-4204 Medical Center North, Nashville, TN, 37232-2584, USA.
    Background: Our aim was to evaluate lipid trafficking and inflammatory response of macrophages exposed to lipoproteins from subjects with moderate to severe chronic kidney disease (CKD), and to investigate the potential benefits of activating cellular cholesterol transporters via liver X receptor (LXR) agonism.

    Methods: LDL and HDL were isolated by sequential density gradient ultracentrifugation of plasma from patients with stage 3-4 CKD and individuals without kidney disease (HDLand HDL, respectively). Uptake of LDL, cholesterol efflux to HDL, and cellular inflammatory responses were assessed in human THP-1 cells. Read More

    Disseminated cryptococcosis presenting initially as lower limb cellulitis in a renal transplant recipient - a case report.
    BMC Nephrol 2018 01 27;19(1):18. Epub 2018 Jan 27.
    Department of Medicine, Mackay Base Hospital, Bridge Road, Mackay, Australia.
    Background: Cellulitis is an unusual presentation of disseminated cryptococcosis, a serious infection seen predominantly in immunocompromised hosts. Disseminated cryptococcosis carries significant morbidity for transplant recipients, especially of the pulmonary and central nervous systems, and carries a high mortality risk.

    Case Presentation: We report a 59-year-old renal transplant recipient who presented with bilateral lower leg cellulitis without other symptoms or signs. Read More

    Simple citrate anticoagulation protocol for low flux haemodialysis.
    BMC Nephrol 2018 01 19;19(1):16. Epub 2018 Jan 19.
    Division of Renal Medicine, Khoo Teck Puat Hospital, Singapore, 768828, Singapore.
    Background: For patients unable to receive heparin anticoagulation during haemodialysis, saline flushes to reduce circuit clotting are often the norm. Regional citrate anticoagulation (RCA) although effective is not used by many centres including in Singapore. We wanted to demonstrate the superiority and safety of a simple regional citrate anticoagulation regime, compared to saline flushes, for heparin-free low flux haemodialysis. Read More

    Therapeutic plasma exchange in a tertiary care center: 185 patients undergoing 912 treatments - a one-year retrospective analysis.
    BMC Nephrol 2018 01 15;19(1):12. Epub 2018 Jan 15.
    Medical Clinic V | Nephrology | Rheumatology | Blood Purification, Academic Teaching Hospital Braunschweig, Braunschweig, Germany.
    Background: Therapeutic plasma exchange (TPE) is increasingly used throughout the world. Although the procedure itself is fairly standardized, it is yet unknown how the underlying disease entities influence the key coordinates of the treatment.

    Methods: Retrospective chart review. Read More

    Safety and adequacy of percutaneous kidney biopsy performed by nephrology trainees.
    BMC Nephrol 2018 01 15;19(1):14. Epub 2018 Jan 15.
    Unit of Nephrology and Dialysis, ICS Maugeri, University of Pavia, Via S. Maugeri 10, 27100, Pavia, Italy.
    Background: Recently there has been a progressive loss of specialty related skills for nephrologists. Among the skills we find the kidney biopsy that has a central role in diagnosis of renal parenchymal disease. One of the causes might be the belief that the kidney biopsy should be performed only in larger Centers which can rely on the presence of a renal pathologist and on nephrologists with a large experience. Read More

    Chronic kidney disease in sugarcane workers in Cameroon: a cross-sectional study.
    BMC Nephrol 2018 01 15;19(1):10. Epub 2018 Jan 15.
    Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box 1364, Yaounde, Cameroon.
    Background: Agricultural workers especially in sugarcane plantations have a high risk of chronic kidney disease (CKD). Little is known about CKD among sugarcane plantation workers in Cameroon. This study sought to evaluate the prevalence and identify factors associated with CKD in sugarcane plantation workers in Cameroon. Read More

    Estimating the total prevalence and incidence of end-stage kidney disease among Aboriginal and non-Aboriginal populations in the Northern Territory of Australia, using multiple data sources.
    BMC Nephrol 2018 01 15;19(1):15. Epub 2018 Jan 15.
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
    Background: Most estimates for End Stage Kidney Disease (ESKD) prevalence and incidence are based on renal replacement therapy (RRT) registers. However, not all people with ESKD will commence RRT and estimates based only on RRT registry data will underestimate the true burden of ESKD in the community. This study estimates the total number of Northern Territory (NT) residents with ESKD including: those receiving RRT, those diagnosed but not receiving RRT and an estimate of "undiagnosed" cases. Read More

    Association of Kidney Disease Quality of Life (KDQOL-36) with mortality and hospitalization in older adults receiving hemodialysis.
    BMC Nephrol 2018 01 15;19(1):11. Epub 2018 Jan 15.
    Durham VA Geriatric Research, Education and Clinical Center, 508 Fulton Street, Durham, NC, 27705, USA.
    Background: For older adults receiving dialysis, health-related quality of life is not often considered in prognostication of death or future hospitalizations. To determine if routine health-related quality of life measures may be useful for prognostication, the objective of this study is to determine the extent of association of Kidney Disease Quality of Life (KDQOL-36) subscales with adverse outcomes in older adults receiving dialysis.

    Methods: This is a longitudinal study of 3500 adults aged ≥75 years receiving dialysis in the United States in 2012 and 2013. Read More

    Process evaluation of the RaDIANT community study: a dialysis facility-level intervention to increase referral for kidney transplantation.
    BMC Nephrol 2018 01 15;19(1):13. Epub 2018 Jan 15.
    Department of Surgery, Division of Transplantation, Emory University School of Medicine, 1629 Pierce Dr. NE, 30322, Atlanta, Georgia, USA.
    Background: The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiveness of a 1-year multicomponent education and quality improvement intervention in increasing referral for kidney transplant evaluation among selected Georgia dialysis facilities.

    Methods: To assess implementation of the RaDIANT intervention, we conducted a process evaluation at the conclusion of the intervention period (January-December 2014). We administered a 20-item survey to the staff involved with transplant education in 67 dialysis facilities randomized to participate in intervention activities. Read More

    Treating C3 glomerulopathy with eculizumab.
    BMC Nephrol 2018 01 12;19(1). Epub 2018 Jan 12.
    Department of Nephrology, Medical Center-University of Freiburg, Germany, Hugstetter Strasse 55, 79106, Freiburg, Germany.
    Background: C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well as inherited dysregulation of the alternative pathway of the complement cascade. Currently, there is no established therapy. Read More

    The use of eculizumab in gemcitabine induced thrombotic microangiopathy.
    BMC Nephrol 2018 01 12;19(1). Epub 2018 Jan 12.
    Department of Internal Medicine and Nephrology, Cleveland Clinic Akron General, 1 Akron General Ave, Akron, OH, 44307, USA.
    Background: Thrombotic microangiopathy (TMA) secondary to gemcitabine therapy (GiTMA) is a very rare pathology that carries a poor prognosis, with nearly half of the cases progressing to end stage renal disease. GiTMA is most commonly associated with adenocarcinomas, most notably pancreatic cancers. The mainstay of management is withdrawal of the offending drug and supportive care. Read More

    Engaging clinicians and patients to assess and improve frailty measurement in adults with end stage renal disease.
    BMC Nephrol 2018 01 12;19(1). Epub 2018 Jan 12.
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Background: The Fried frailty phenotype, a measure of physiologic reserve defined by 5 components (exhaustion, unintentional weight loss, low physical activity, slow walking speed, and poor grip strength), is associated with poor outcomes among ESRD patients. However, these 5 components may not fully capture physiologic reserve in this population. We aimed to ascertain opinions of ESRD clinicians and patients about the usefulness of the Fried frailty phenotype and interventions to improve frailty in ESRD patients, and to identify novel components to further characterize frailty in ESRD. Read More

    Distribution of glomerular diseases in Taiwan: preliminary report of National Renal Biopsy Registry-publication on behalf of Taiwan Society of Nephrology.
    BMC Nephrol 2018 01 10;19(1). Epub 2018 Jan 10.
    Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
    Background: Despite the development of biomarkers and noninvasive imaging tools, biopsy remains the only method for correctly diagnosing patients with unexplained hematuria, proteinuria and renal failure. Renal biopsy has been performed for several decades in Taiwan; however, a national data registry is still lacking until 2013.

    Methods: The Renal Biopsy Registry Committee was established within the Taiwan Society of Nephrology in January 2013. Read More

    Dialysis facility staff perceptions of racial, gender, and age disparities in access to renal transplantation.
    BMC Nephrol 2018 01 10;19(1). Epub 2018 Jan 10.
    Department of Surgery, Division of Transplantation, Emory University School of Medicine, 1639 Pierce Dr. NE, Atlanta, GA, 30322, USA.
    Background: Racial/ethnic, gender, and age disparities in access to renal transplantation among end-stage renal disease (ESRD) patients have been well documented, but few studies have explored health care staff attitudes towards these inequalities. Staff perceptions can influence patient care and outcomes, and identifying staff perceptions on disparities could aid in the development of potential interventions to address these health inequities. The objective of this study was to investigate dialysis staff (n = 509), primarily social workers and nurse managers, perceptions of renal transplant disparities in the Southeastern United States. Read More

    Warfarin anticoagulation in hemodialysis patients with atrial fibrillation: comparison of nephrologist-led and anticoagulation clinic-led management.
    BMC Nephrol 2018 01 8;19(1). Epub 2018 Jan 8.
    Division of Nephrology, Department of Medicine, Jewish General Hospital, Montreal, Canada.
    Background: There is conflicting evidence of benefit versus harm for warfarin anticoagulation in hemodialysis patients with atrial fibrillation. This equipoise may be explained by suboptimal Time in Therapeutic Range (TTR), which correlates well with thromboembolic and bleeding complications. This study aimed to compare nephrologist-led management of warfarin therapy versus that led by specialized anticoagulation clinic. Read More

    Assessing cardiovascular risk in chronic kidney disease patients prior to kidney transplantation: clinical usefulness of a standardised cardiovascular assessment protocol.
    BMC Nephrol 2018 01 8;19(1). Epub 2018 Jan 8.
    Renal and Transplantation Unit, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, Tooting, London, SW17 0QT, UK.
    Background: Despite pre-kidney-transplant cardiovascular (CV) assessment being routine care to minimise perioperative risk, the utility of such assessment is not well established. The study reviewed the evaluation and outcome of a standardised CV assessment protocol.

    Methods: Data were analysed for 231 patients (age 53. Read More

    Uncontrolled donation after circulatory death: comparison of two kidney preservation protocols on graft outcomes.
    BMC Nephrol 2018 01 8;19(1). Epub 2018 Jan 8.
    Hospices Civils de Lyon, Hôpital Edouard Herriot, Université Claude Bernard Lyon 1, service d'Anesthésie Réanimation, Lyon, France.
    Background: Kidney transplantation following uncontrolled donation after circulatory death (uDCD) presents a high risk of delayed graft function due to prolonged warm ischemia time. In order to minimise the effects of ischemia/reperfusion injury during warm ischemia, normothermic recirculation recently replaced in situ perfusion prior to implantation in several institutions. The aim of this study was to compare these preservation methods on kidney graft outcomes. Read More

    Assessment of the association between increasing membrane pore size and endotoxin permeability using a novel experimental dialysis simulation set-up.
    BMC Nephrol 2018 01 5;19(1). Epub 2018 Jan 5.
    Department of Internal Medicine, Nephrology Division, Ghent University Hospital, Gent, Belgium.
    Background: Membranes with increasing pore size are introduced to enhance removal of large uremic toxins with regular hemodialysis. These membranes might theoretically have higher permeability for bacterial degradation products. In this paper, permeability for bacterial degradation products of membranes of comparable composition with different pore size was investigated with a new in vitro set-up that represents clinical flow and pressure conditions. Read More

    Systematic review of nephrotoxicity of drugs of abuse, 2005-2016.
    BMC Nephrol 2017 12 29;18(1):379. Epub 2017 Dec 29.
    Joan C. Edwards School of Medicine, Marshall University, 1690 Medical Center Drive, Huntington, WV, 25701, USA.
    Background: The United States is faced with an unprecedented epidemic of drug abuse. Every year thousands of Americans visit the emergency departments all over the country with illicit drug related complaints. These drugs have been known to be associated with a range of renal pathologies, from reversible acute kidney injuries to debilitating irreversible conditions like renal infarction. Read More

    Rapid clinical improvement of amyloid A amyloidosis following treatment with tocilizumab despite persisting amyloid deposition: a case report.
    BMC Nephrol 2017 12 29;18(1):377. Epub 2017 Dec 29.
    Department of Nephrology and Endocrinology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
    Background: Amyloid A amyloidosis is one of the most common forms of amyloidosis. It is secondary to rheumatoid arthritis, which is difficult to manage and has a poor prognosis. We present a patient with rheumatoid arthritis and amyloid A amyloidosis who was treated with tocilizumab, a humanized monoclonal antibody against interleukin 6 receptor, resulting in improvement in both proteinuria and gastrointestinal symptoms; however, amyloid deposition remained. Read More

    Relation between duration of the prodromal phase and renal damage in ANCA-associated vasculitis.
    BMC Nephrol 2017 12 29;18(1):378. Epub 2017 Dec 29.
    Department of Internal Medicine, Northwest Clinics, Wilhelminalaan 12, 1815 JD, Alkmaar, The Netherlands.
    Background: In ANCA-associated vasculitis the acute phase of the disease is often preceded by prodromal symptoms. The aim of the present study was to analyze the relation between the duration of the prodromal phase and renal damage.

    Methods: Patients with ANCA-associated vasculitis and renal involvement from a retrospective single-center cohort were divided into two equal groups based on the duration of the prodromal phase. Read More

    The impact of intravenous methylprednisolone pulses on renal survival in anti-neutrophil cytoplasmic antibody associated vasculitis with severe renal injury patients: a retrospective study.
    BMC Nephrol 2017 12 29;18(1):381. Epub 2017 Dec 29.
    Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
    Background: High-dose methylprednisolone pulses were one of the main treatments for anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitides (AAV) but had obvious side effects. We aimed to know the impact on renal survival and identify the prognostic factors of this treatment in Chinese AAV patients with severe renal involvement.

    Methods: One hundred and eleven AAV patients with an estimated glomerular filtration rate (eGFR) of 10ml/min/1. Read More

    Risk factors for community-acquired acute kidney injury in patients with and without chronic kidney injury and impact of its initial management on prognosis: a prospective observational study.
    BMC Nephrol 2017 12 29;18(1):380. Epub 2017 Dec 29.
    Nephrology Unit, Department of Medical Specialties, Geneva University Hospitals, 4 rue Gabrielle Perret-Gentil, 1211, Geneva, Switzerland.
    Background: We aimed to describe clinical characteristics of patients with community-acquired acute kidney injury (CA-AKI), the effectiveness of initial management of CA-AKI, its prognosis and the impact of medication on its occurrence in patients with previous chronic kidney injury (CKI).

    Methods: We undertook a prospective observational study within the Emergency Department (ED) of a University Hospital, screening for any patient >16 years admitted with an eGFR <60 ml/mn/1.73 mand a rise in serum creatinine as compared to previous values. Read More


    Spectrum (characteristics) of patients with chronic kidney disease (CKD) with increasing age in a major metropolitan renal service.
    BMC Nephrol 2017 12 28;18(1):372. Epub 2017 Dec 28.
    NHMRC CKD.CRE & CKD.QLD, Brisbane, QLD, Australia.
    Background: Aim of our study is to describe, in people with CKD, the demographic and clinical characteristics and outcomes with increasing age. The prevalence of CKD in Western populations, where longevity is the norm, is about 10-15%, but how age influence different characteristics of patients with CKD is largely not known.

    Methods: One thousand two hundred sixty-five patients enrolled in the CKD. Read More

    Health care costs associated with hospital acquired complications in patients with chronic kidney disease.
    BMC Nephrol 2017 12 28;18(1):375. Epub 2017 Dec 28.
    Department of Medicine, University of Alberta, 11-112R Clinical Sciences Building, 8440-112 Street, Edmonton, AB, T6G2G3, Canada.
    Background: Patients with CKD are at increased risk of potentially preventable hospital acquired complications (HACs). Understanding the economic consequences of preventable HACs, may define the scope and investment of initiatives aimed at prevention.

    Methods: Adult patients hospitalized from April, 2003 to March, 2008 in Alberta, Canada comprised the study cohort. Read More

    Fluid status evaluation by inferior vena cava diameter and bioimpedance spectroscopy in pediatric chronic hemodialysis.
    BMC Nephrol 2017 12 28;18(1):373. Epub 2017 Dec 28.
    Department of Paediatric Nephrology and Hemodialysis, Hôpital Robert Debré, APHP, 48 boulevard Sérurier 75019, 19, Paris Cedex, France.
    Background: Evaluation of patient's dry weight remains challenging in chronic hemodialysis (HD) especially in children. Inferior Vena Cava (IVC) measurement was reported useful to assess fluid overload both in adults and children.

    Methods: We performed a monocentric prospective study to evaluate the relation between predialytic IVC diameter measurements and hydration status evaluated by physicians and bioimpedance spectroscopy (BIS) and between IVC measurements and persistent hypertension. Read More

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