2,160 results match your criteria BMC Nephrology[Journal]


Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study.

BMC Nephrol 2019 Feb 21;20(1):61. Epub 2019 Feb 21.

Department of Clinical Sciences, Lund University, Malmö, CRC 60:13, Jan Waldenströms gata 35, S-20502, Malmö, Sweden.

Background: Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we examined whether elevated C3 concentration is associated with hospitalization due to CKD in the general population, and whether this relationship is mediated by factors such as diabetes and hypertension. Read More

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http://dx.doi.org/10.1186/s12882-019-1248-7DOI Listing
February 2019

A huge benign fibrous histiocytoma arising from the renal capsule: report of a case.

BMC Nephrol 2019 Feb 21;20(1):62. Epub 2019 Feb 21.

Department of Nursing, The third the People's Hospital of Bengbu, 38# Shengli Road, Bengbu, Anhui Province, China.

Background: Neoplasms originating in the renal capsule are very rare. Benign fibrous histiocytoma(BFH) most commonly occurs in the dermis and subcutis, few cases of this tumor appear in the renal capsule. In particular, BFH larger than 20 cm are scarce. Read More

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http://dx.doi.org/10.1186/s12882-019-1256-7DOI Listing
February 2019

Unilateral renal artery stenosis presented with hyponatremic-hypertensive syndrome - case report and literature review.

BMC Nephrol 2019 Feb 21;20(1):64. Epub 2019 Feb 21.

Division of Nephrology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, No 5, Fu-Shing ST., Kwei-Shan, 33305, Taoyuan, Taiwan.

Background: Renal artery stenosis is one of the secondary causes of pediatric hypertension. Cases with critical unilateral renal artery stenosis manifesting with the hyponatremic hypertensive syndrome are rare and a comprehensive description of this disorder in the pediatric population is lacking in the literature.

Case Presentation: We describe a 4-year-old boy who presented with severe hypertension, profound hyponatremia, hypokalemia, nephrotic range proteinuria, and polyuria. Read More

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http://dx.doi.org/10.1186/s12882-019-1246-9DOI Listing
February 2019

Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients.

BMC Nephrol 2019 Feb 21;20(1):63. Epub 2019 Feb 21.

Department of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430033, People's Republic of China.

Background: Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk factors of cerebrovascular disease. The purpose of the present study is to determine the relationship between serum klotho and cerebrovascular disease in patients receiving hemodialysis. Read More

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http://dx.doi.org/10.1186/s12882-019-1232-2DOI Listing
February 2019

Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study.

BMC Nephrol 2019 Feb 20;20(1):60. Epub 2019 Feb 20.

Division of Renal-Electrolyte and Hypertension, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 19103, PA, USA.

Background: Insulin resistance contributes to the metabolic syndrome, which is associated with the development of kidney disease. However, it is unclear if insulin resistance independently contributes to an increased risk of chronic kidney disease (CKD) progression or CKD complications. Additionally, predisposing factors responsible for insulin resistance in the absence of diabetes in CKD are not well described. Read More

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http://dx.doi.org/10.1186/s12882-019-1220-6DOI Listing
February 2019

Differences in association of lower bone mineral density with higher coronary calcification in female and male end-stage renal disease patients.

BMC Nephrol 2019 Feb 18;20(1):59. Epub 2019 Feb 18.

Division of Renal Medicine and Baxter Novum, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Background: Risk of cardiac events and cardiovascular disease (CVD) in end-stage renal disease (ESRD) patients are predicted by coronary artery calcification (CAC) independently. It is not clear to what extent low bone mineral density (BMD) is associated with higher risk of CAC and if sex interacts. We investigated the sex-specific associations of CAC score with total body BMD (tBMD) as well as with BMD of different skeletal sub-regions. Read More

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http://dx.doi.org/10.1186/s12882-019-1235-zDOI Listing
February 2019

Intravenous pulse methylprednisolone for induction of remission in severe ANCA associated Vasculitis: a multi-center retrospective cohort study.

BMC Nephrol 2019 Feb 18;20(1):58. Epub 2019 Feb 18.

Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.

Background: Intravenous pulse methylprednisolone (MP) is commonly included in the management of severe ANCA associated vasculitis (AAV) despite limited evidence of benefit. We aimed to evaluate outcomes in patients who had, or had not received MP, along with standard therapy for remission induction in severe AAV.

Methods: We retrospectively studied 114 consecutive patients from five centres in Europe and the United States with a new diagnosis of severe AAV (creatinine > 500 μmol/L or dialysis dependency) and that received standard therapy (plasma exchange, cyclophosphamide and high-dose oral corticosteroids) for remission induction with or without pulse MP between 2000 and 2013. Read More

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http://dx.doi.org/10.1186/s12882-019-1226-0DOI Listing
February 2019

Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study.

BMC Nephrol 2019 Feb 14;20(1):57. Epub 2019 Feb 14.

Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China.

Background: Protein-bound uremic toxins are associated with poor outcomes in patients with chronic kidney disease. The aim of this study is to investigate the relationship between indoxyl sulfate (IS), a protein-bound solute, and 90-day mortality in patients with acute kidney injury.

Methods: Adults with hospital-acquired AKI (HA-AKI) were enrolled in this prospective cohort study between 2014 and 2015, according to the KDIGO creatinine criteria. Read More

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http://dx.doi.org/10.1186/s12882-019-1238-9DOI Listing
February 2019
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Angiotensin II receptor blockade is associated with preserved muscle strength in chronic hemodialysis patients.

BMC Nephrol 2019 Feb 14;20(1):54. Epub 2019 Feb 14.

Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.

Background: Sarcopenia, defined as low muscle mass and strength, is highly prevalent in patients undergoing chronic hemodialysis (HD). However, muscle function and muscle mass do not share the same clinical relevance. In fact, muscle strength was more closely associated with the risk of mortality in chronic HD patients than was muscle mass. Read More

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http://dx.doi.org/10.1186/s12882-019-1223-3DOI Listing
February 2019

Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft.

BMC Nephrol 2019 Feb 14;20(1):53. Epub 2019 Feb 14.

Department of Pathology, Division of Renal and Transplant Pathology, Ohio State University Wexner Medical Center, M018 Starling-Loving Hall, 320 W 10th Ave, Columbus, OH, 43210, USA.

Background: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of "Monoclonal gammopathy-related kidney diseases", and can recur after transplant. Clinical remission of proteinuria in patients with PGNMIGD has been previously shown following anti-B cell and/or anti-plasma cell therapies. Our case is the first to show complete histologic resolution of the glomerular monoclonal IgG kappa deposits in a case of recurrent PGNMIGD in renal allograft after rituximab and steroid treatment. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1239-8DOI Listing
February 2019
2 Reads

Identifying on admission patients likely to develop acute kidney injury in hospital.

BMC Nephrol 2019 Feb 14;20(1):56. Epub 2019 Feb 14.

Research, Development, and Innovation, Royal Cornwall Hospitals NHS Trust, Truro, TR1 3HD, UK.

Background: The incidence of Acute Kidney Injury (AKI) continues to increase in the UK, with associated mortality rates remaining significant. Approximately one fifth of hospital admissions are associated with AKI and approximately a third of patients with AKI in hospital develop AKI during their time in hospital. A fifth of these cases are considered avoidable. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1237-xDOI Listing
February 2019
3 Reads

Revisiting racial differences in ESRD due to ADPKD in the United States.

BMC Nephrol 2019 Feb 14;20(1):55. Epub 2019 Feb 14.

Section of Nephrology, Yale University School of Medicine, New Haven, CT, 06520, USA.

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) affects all races. Whether the progression of ADPKD varies by race remains unclear.

Methods: In this retrospective cohort study from 2004 to 2013 non-Hispanic blacks and non-Hispanic whites of all ages classified in the US Renal Data System (USRDS) with incident ESRD from ADPKD (n = 23,647), hypertension/large vessel disease (n = 296,352), or diabetes mellitus (n = 451,760) were stratified into five-year age categories ranging from < 40 to > 75 (e. Read More

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http://dx.doi.org/10.1186/s12882-019-1241-1DOI Listing
February 2019

Improved long-term survival with home hemodialysis compared with institutional hemodialysis and peritoneal dialysis: a matched cohort study.

BMC Nephrol 2019 Feb 13;20(1):52. Epub 2019 Feb 13.

Department of Clinical Sciences Lund, University, Skane University Hospital, Nephrology Lund, Lund, Sweden.

Background: The survival rate for dialysis patients is poor. Previous studies have shown improved survival with home hemodialysis (HHD), but this could be due to patient selection, since HHD patients tend to be younger and healthier. The aim of the present study is to analyse the long-term effects of HHD on patient survival and on subsequent renal transplantation, compared with institutional hemodialysis (IHD) and peritoneal dialysis (PD), taking age and comorbidity into account. Read More

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http://dx.doi.org/10.1186/s12882-019-1245-xDOI Listing
February 2019

Correction to: The elevated levels of urinary angiotensinogen are correlated with the severity of idiopathic membranous nephropathy.

BMC Nephrol 2019 Feb 13;20(1):50. Epub 2019 Feb 13.

Department of Nephrology, Peking University Third Hospital, No. 49, North Garden Road, Haidian District, Beijing, 100191, China.

Following publication of the original article [1], it was reported that, due to a typesetting mistake, the three tables and two figures for this article were included as an Additional file instead of in the body of the article. The original publication of this article has been updated to correct this. Read More

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http://dx.doi.org/10.1186/s12882-019-1229-xDOI Listing
February 2019

Post renal transplant anemia: severity, causes and their association with graft and patient survival.

BMC Nephrol 2019 Feb 13;20(1):51. Epub 2019 Feb 13.

Department of Nephrology and Hypertension, Rabin Medical Center, Petah Tikva, Israel.

Background: Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased mortality. However, the effect of the severity of anemia on this associations was not thoroughly evaluated. Read More

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http://dx.doi.org/10.1186/s12882-019-1244-yDOI Listing
February 2019
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Development and preliminary results on the feasibility of a renal diet specific question prompt sheet for use in nephrology clinics.

BMC Nephrol 2019 Feb 12;20(1):48. Epub 2019 Feb 12.

Department of Clinical Nutrition, Wollongong Hospital, Illawarra Shoalhaven Local Health District, Level 5 Block C, Crown Street, Wollongong, NSW, 2500, Australia.

Background: Adherence to the diet prescription for chronic kidney disease is suboptimal. Interventions to improve dietary adherence suggest that improving communication between the patient and the health professional is fundamental to improving outcomes. Providing patients with a question prompt sheet prior to the consultation has been demonstrated to be an effective method for improving communication between patient and health professional. Read More

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http://dx.doi.org/10.1186/s12882-019-1231-3DOI Listing
February 2019

Magnesium lithospermate B improves renal hemodynamics and reduces renal oxygen consumption in 5/6th renal ablation/infarction rats.

BMC Nephrol 2019 Feb 12;20(1):49. Epub 2019 Feb 12.

Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No.528 Zhangheng Road, Pudong District, Shanghai, 201203, People's Republic of China.

Background: Magnesium lithospermate B (MLB) can promote renal microcirculation. The aim of the current project was to study whether MLB improves renal hemodynamics, oxygen consumption and subsequently attenuates hypoxia in rats induced by 5/6th renal Ablation/Infarction(A/I).

Methods: Chronic renal failure (CRF) was induced in male SD rats by the 5/6 (A/I) surgery. Read More

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http://dx.doi.org/10.1186/s12882-019-1221-5DOI Listing
February 2019
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Blood volume analysis as a guide for dry weight determination in chronic hemodialysis patients: a crossover study.

BMC Nephrol 2019 Feb 11;20(1):47. Epub 2019 Feb 11.

Nephrology Division, NYU School of Medicine and NYU Langone Medical Center, New York University School of Medicine, 423 E. 23 St., New York, NY, USA.

Background: Volume overload and depletion both lead to high morbidity and mortality. Achieving euvolemia is a challenge in patients with end stage kidney disease on hemodialysis (HD). Blood volume analysis (BVA) uses radiolabeled albumin to determine intravascular blood volume (BV). Read More

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http://dx.doi.org/10.1186/s12882-019-1211-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371522PMC
February 2019

Pre-donation BMI and preserved kidney volume can predict the cohort with unfavorable renal functional compensation at 1-year after kidney donation.

BMC Nephrol 2019 Feb 8;20(1):46. Epub 2019 Feb 8.

Department of Urology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Background: The magnitude of renal function recovery after kidney donation differs in donors with a heterogeneous background. Preoperative assessment of candidates with potentially unfavorable renal functional compensation is critical when baseline kidney function is marginal. We explored the significance of preserved kidney volume (PKV) and known preoperative risk factors for the prediction of unfavorable renal function compensation. Read More

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http://dx.doi.org/10.1186/s12882-019-1242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368798PMC
February 2019

Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study.

BMC Nephrol 2019 Feb 7;20(1):45. Epub 2019 Feb 7.

Department of Radiology, Pediatric Radiology, University Hospital of Bonn, Bonn, Germany.

Background: Nephrotic syndrome (NS) is one of the most frequent occurring chronic kidney diseases in childhood, despite its rarely occurrence in the general population. Detailed information about clinical data of NS (e.g. Read More

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http://dx.doi.org/10.1186/s12882-019-1233-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367765PMC
February 2019
5 Reads

The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa.

BMC Nephrol 2019 Feb 6;20(1):44. Epub 2019 Feb 6.

Division of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Background: The aim of this study was to assess, the efficacy and safety of add-on corticosteroids to antiretroviral therapy [ART] in patients with biopsy proven HIV associated nephropathy.

Methods: All included patients had histological evidence of either collapsing or non-collapsing focal segmental glomerulosclerosis (FSGS) or podocyte and/or parietal cell hypertrophy or hyperplasia. All patients had evidence of tubulointerstitial inflammation with microcysts. Read More

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http://dx.doi.org/10.1186/s12882-019-1208-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366071PMC
February 2019
1 Read

Multidimensional pruritus assessment in hemodialysis patients.

BMC Nephrol 2019 Feb 6;20(1):42. Epub 2019 Feb 6.

Medical Nursing Department, Hacettepe University Faculty of Nursing, Sihhiye/Ankara, Turkey.

Background: Pruritus is a distressing, life-limiting symptom in chronic renal failure, affecting 40% of patients. This study aimed to determine uremic pruritus prevalence and investigate the multidimensional impact on hemodialysis patients.

Methods: This descriptive study was performed between March and June 2016. Read More

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http://dx.doi.org/10.1186/s12882-019-1234-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366049PMC
February 2019
1 Read

Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report.

BMC Nephrol 2019 Feb 6;20(1):43. Epub 2019 Feb 6.

Department of Nephrology, Okazaki City Hospital, 3-1 Goshoai Koryuzi-cho, Okazaki, Aichi, 444-8553, Japan.

Background: Thrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignancy. However, there are few case reports on THSD7A-associated MN with malignancy, and details of its characteristics have not been clarified thoroughly. Read More

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http://dx.doi.org/10.1186/s12882-019-1236-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366086PMC
February 2019
1 Read

Impact of thyroid function on cystatin C in detecting acute kidney injury: a prospective, observational study.

BMC Nephrol 2019 Feb 6;20(1):41. Epub 2019 Feb 6.

Department of Intensive Care Unit of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, 96 Dongchuan Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.

Background: Cystatin C (Cys C) used clinically for detecting early acute kidney injury (AKI) was reported to be associated with thyroid function. Therefore, whether the performance of Cys C is affected by thyroid hormones has raised concern in critically ill patients. This study aimed to investigate the impact of thyroid hormones on the diagnostic and predictive accuracy of Cys C for AKI, and hence optimize the clinical application of Cys C. Read More

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http://dx.doi.org/10.1186/s12882-019-1201-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364411PMC
February 2019
1 Read

Impact of acute kidney injury in expanded criteria deceased donors on post-transplant clinical outcomes: multicenter cohort study.

BMC Nephrol 2019 Feb 4;20(1):39. Epub 2019 Feb 4.

Transplant Research Center, Seoul, South Korea.

Background: The problem of organ shortage is an important issue in kidney transplantation, but the effect of kidney donation on AKI is unclear. The aim of this study was to investigate the impact of acute kidney injury (AKI) on post-transplant clinical outcomes for deceased donor kidney transplantation (DDKT) using standard criteria donors (SCDs) versus expanded criteria donors (ECDs).

Methods: Five-hundred nine KT recipients receiving kidneys from 386 deceased donors (DDs) were included from three transplant centers. Read More

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http://dx.doi.org/10.1186/s12882-019-1225-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360778PMC
February 2019
1 Read

Outcome of kidney function after ischaemic and zero-ischaemic laparoscopic and open nephron-sparing surgery for renal cell cancer.

BMC Nephrol 2019 Feb 4;20(1):40. Epub 2019 Feb 4.

Department of Urology, Charité - University Hospital, Berlin, Germany.

Background: Nephron-sparing surgery (NSS) remains gold standard for the treatment of localised renal cell cancer (RCC), even in case of a normal contralateral kidney. Compared to radical nephrectomy, kidney failure and cardiovascular events are less frequent with NSS. However, the effects of different surgical approaches and of zero ischaemia on the postoperative reduction in renal function remain controversial. Read More

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http://dx.doi.org/10.1186/s12882-019-1215-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362593PMC
February 2019
1 Read

A randomized controlled trial of different serum phosphate ranges in subjects on hemodialysis.

BMC Nephrol 2019 Feb 4;20(1):37. Epub 2019 Feb 4.

Manchester Academic Health Science Center, Manchester, UK.

Background: Hyperphosphataemia in dialysis subjects is associated with increased mortality. However cause and effect has not been proven, and the ideal phosphate target range is unknown despite KDOQI's call for studies over 12 years ago. The design and conduct of a randomized controlled trial is challenging because maintaining two groups within differing target ranges of serum phosphate has not been achieved over a long follow-up of 1 year, in a trial setting, before. Read More

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http://dx.doi.org/10.1186/s12882-019-1216-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360717PMC
February 2019
1 Read

The views and experiences of older people with conservatively managed renal failure: a qualitative study of communication, information and decision-making.

BMC Nephrol 2019 Feb 4;20(1):38. Epub 2019 Feb 4.

Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK.

Background: Older people with advanced kidney disease require information and support from clinicians when deciding whether to have dialysis or conservative (non-dialysis) care. There is evidence that communication practices, information provision and treatment rates vary widely across renal units. However, experiences of communicating with clinicians among patients receiving conservative care are poorly understood. Read More

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http://dx.doi.org/10.1186/s12882-019-1230-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360769PMC
February 2019
2 Reads

A prospective study of daclatasvir and sofosbuvir in chronic HCV-infected kidney transplant recipients.

BMC Nephrol 2019 Feb 4;20(1):36. Epub 2019 Feb 4.

Department of Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Augustenburger Platz, 13353, Berlin, Germany.

Background: Only a few prospective trials exist regarding the use of novel direct-acting antiviral agents (DAAs) in kidney transplant recipients (KTR) with chronic hepatitis C virus (HCV) infection.

Methods: This prospective single-center trial evaluated treatment with daclatasvir (DCV) and sofosbuvir (SOF) over 12 weeks in 16 adult chronic HCV infected KTR and eGFR > 30 ml/min/1.73m. Read More

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http://dx.doi.org/10.1186/s12882-019-1218-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360788PMC
February 2019
1 Read

Outcomes and practice patterns with hemodiafiltration in Shanghai: a longitudinal cohort study.

BMC Nephrol 2019 Feb 1;20(1):34. Epub 2019 Feb 1.

Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Background: Globally, there is increased clinical interest and uptake of hemodiafiltration (HDF) for increased removal of uremic toxins. To date, there has been no epidemiological analysis of HDF in China. We present HDF practice patterns and associated mortality risk in Shanghai. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1219-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359843PMC
February 2019
4 Reads

Clinical outcomes of hemodialysis patients in a public-private partnership care framework in Italy: a retrospective cohort study.

BMC Nephrol 2019 Feb 1;20(1):35. Epub 2019 Feb 1.

Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.

Background: Innovative care models such as public-private partnerships (PPPs) may help meet the challenge of providing cost-effective high-quality care for the steadily growing and complex chronic kidney disease population since they combine the expertise and efficiency of a specialized dialysis provider with the population care approach of a public entity. We report the five-years main clinical outcomes of a population of patients treated on hemodialysis within a PPP-care model in Italy.

Methods: This descriptive retrospective cohort study consisted of all consecutive hemodialysis patients treated in the NephroCare-operated Nephrology and Dialysis unit of the Seriate Hospital in 2012-2016, which exercises a PPP-care model. Read More

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http://dx.doi.org/10.1186/s12882-019-1224-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359808PMC
February 2019

Long term metabolic and renal outcomes of kidney donors compared to controls with excellent kidney function.

BMC Nephrol 2019 Jan 31;20(1):30. Epub 2019 Jan 31.

Department of Internal Medicine "C", "D" and "E", Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Only few studies of living kidney donors have included controls that were similarly healthy, including excellent kidney function.

Methods: In this study, we aimed to estimate long term metabolic and renal outcome in a cohort of 211 living donors compared to two control groups: paired-matched controls, and another control group of 2534 healthy individuals with excellent kidney function.

Results: Donors presented with higher estimated Glomerular Filtration Rate (eGFR): (97. Read More

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http://dx.doi.org/10.1186/s12882-019-1214-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357355PMC
January 2019
1 Read

A case of aggressive atypical anti-GBM disease complicated by CMV pneumonitis.

BMC Nephrol 2019 Jan 31;20(1):29. Epub 2019 Jan 31.

Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Foothills Medical Center, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada.

Background: Anti-glomerular basement membrane (anti-GBM) disease is characterized by circulating IgG glomerular basement membrane antibodies and is clinically expressed as a rapidly progressive crescentic glomerulonephritis (GN), with 30-60% of patients also developing pulmonary hemorrhage. Classically, the renal biopsy shows glomerular crescent formation, bright linear staining of glomerular basement membranes (GBM) for IgG on direct immunofluorescence (IF), and the serologic presence of circulating anti-GBM antibodies. Recently, patients with linear IgG IF staining, undetectable circulating anti-GBM antibodies and glomerular changes atypical for anti-GBM disease have been described as "atypical anti-GBM disease", with a distinctly more benign clinical course than typical anti-GBM disease. Read More

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http://dx.doi.org/10.1186/s12882-019-1227-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357502PMC
January 2019
2 Reads

The value of maintaining normokalaemia and enabling RAASi therapy in chronic kidney disease.

BMC Nephrol 2019 Jan 31;20(1):31. Epub 2019 Jan 31.

Department of Cardiology, Royal Free Hospital, London, UK.

Background: People with chronic kidney disease (CKD) are at an increased risk of developing hyperkalaemia due to their declining kidney function. In addition, these patients are often required to reduce or discontinue guideline-recommended renin-angiotensin-aldosterone system inhibitor (RAASi) therapy due to increased risk of hyperkalaemia. This original research developed a model to quantify the health and economic benefits of maintaining normokalaemia and enabling optimal RAASi therapy in patients with CKD. Read More

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http://dx.doi.org/10.1186/s12882-019-1228-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357372PMC
January 2019
1 Read

Electronic health records accurately predict renal replacement therapy in acute kidney injury.

BMC Nephrol 2019 Jan 31;20(1):32. Epub 2019 Jan 31.

Division of Nephrology, University Medicine Cluster, National University Hospital, Level 10 Medicine Office, NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.

Background: Electronic health records (EHR) detect the onset of acute kidney injury (AKI) in hospitalized patients, and may identify those at highest risk of mortality and renal replacement therapy (RRT), for earlier targeted intervention.

Methods: Prospective observational study to derive prediction models for hospital mortality and RRT, in inpatients aged ≥18 years with AKI detected by EHR over 1 year in a tertiary institution, fulfilling modified KDIGO criterion based on serial serum creatinine (sCr) measures.

Results: We studied 3333 patients with AKI, of 77,873 unique patient admissions, giving an AKI incidence of 4%. Read More

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http://dx.doi.org/10.1186/s12882-019-1206-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357378PMC
January 2019
1 Read

The association of tumor necrosis factor superfamily 13 with recurrence of immunoglobulin A nephropathy in living related kidney transplantation.

BMC Nephrol 2019 Jan 31;20(1):33. Epub 2019 Jan 31.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: An increasing amount of evidence has demonstrated an association between an increase in the level of tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) progression. We aimed to evaluate if the level of pre-transplant serum TNFSF13 is predictive of IgAN recurrence after kidney transplantation.

Methods: This analysis was based on the clinical and laboratory data of 69 patients with IgAN who underwent first kidney transplantation with no evidence of mesangial IgA deposits in zero-time transplantation biopsy. Read More

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http://dx.doi.org/10.1186/s12882-019-1222-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357388PMC
January 2019
1 Read

Acute kidney injury in patients with myocardial infarction undergoing percutaneous coronary intervention using radial versus femoral access.

BMC Nephrol 2019 Jan 30;20(1):28. Epub 2019 Jan 30.

Division of Internal Medicine, Department of Cardiology and Angiology, University Medical Center Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia.

Background: Data on radial access (RA) as an independent risk factor for acute kidney injury (AKI) in myocardial infarction (MI) patients are conflicting. Our aim was to assess how RA influences the incidence of AKI in MI patients undergoing percutaneous coronary intervention (PCI).

Methods: Data from 3842 MI patients undergoing PCI at our institution from January 2011 to December 2016, of which 35. Read More

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http://dx.doi.org/10.1186/s12882-019-1210-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354416PMC
January 2019

Hemophagocytic lymphohistiocytosis followed by an episode of peritoneal dialysis associated peritonitis: a case report.

BMC Nephrol 2019 Jan 29;20(1):27. Epub 2019 Jan 29.

Renal Division, Department of Medicine, Peking University First Hospital; Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China; and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, 8 Xishiku Street; Xicheng District, Beijing, China.

Background: Hemophagocytic lymphohistiocytosis (HLH) is characterized by excessive activation of the immune system due to infection, autoimmune diseases, or malignancy. As an aggressive and life-threatening clinical syndrome, HLH secondary to peritoneal dialysis associated peritonitis (PDAP) has never been reported.

Case Presentation: A 34-year-old female peritoneal dialysis (PD) patient was hospitalized for fever, progressively multi-organ damage (including cytopenias, abnormalities of coagulation and liver enzyme) after an episode of organism-specific peritonitis. Read More

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http://dx.doi.org/10.1186/s12882-019-1217-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352365PMC
January 2019

Evaluating the effect of garlic extract on serum inflammatory markers of peritoneal dialysis patients: a randomized double-blind clinical trial study.

BMC Nephrol 2019 Jan 25;20(1):26. Epub 2019 Jan 25.

Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Garlic can be considered as a useful natural herb in inhibition of inflammation. The aim of this study was to assess the effectiveness of garlic extract in lowering inflammatory markers in peritoneal dialysis (PD) patients.

Methods: In this parallel-designed double blind randomized clinical trial, 42 PD patients at the Shafa dialysis center, Tehran in 2017 were included. Read More

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http://dx.doi.org/10.1186/s12882-019-1204-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347806PMC
January 2019
3 Reads

Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report.

BMC Nephrol 2019 Jan 25;20(1):25. Epub 2019 Jan 25.

Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo, 193-0998, Japan.

Background: Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy. We present a rare case having a combination of these two diseases, and furthermore, histological evaluation could be performed before and after the development of anti-GBM glomerulonephritis over a period of only10 months.

Case Presentation: A 66-year-old woman was admitted with complaints of microscopic hematuria and mild proteinuria for the past 3 years. Read More

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http://dx.doi.org/10.1186/s12882-019-1207-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347754PMC
January 2019
2 Reads

Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review.

BMC Nephrol 2019 Jan 23;20(1):24. Epub 2019 Jan 23.

Division of Neonatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA.

Background: Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes.

Methods: We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials from date of inception through August 2017 for studies reporting pregnancy with kidney transplant. Read More

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http://dx.doi.org/10.1186/s12882-019-1213-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345071PMC
January 2019
8 Reads

Simultaneous occurrence of IgG4-related Tubulointerstitial nephritis and colon adenocarcinoma with hepatic metastasis: a case report and literature review.

BMC Nephrol 2019 Jan 16;20(1):23. Epub 2019 Jan 16.

Department of Nephrology, West China Hospital, Sichuan University, Chengdu, 610041, China.

Background: Understanding the uncommon association of IgG4-related disease with other disorders is essential for the accurate diagnosis and effective treatment of patients. To the best of our knowledge, there have been only few reports of patients with IgG4-related kidney disease coexisting with metastasis of malignancy. Here, we report a rare case of simultaneous occurring IgG4-related tubulointerstitial nephritis and colon adenocarcinoma with hepatic metastasis. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1205-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335794PMC
January 2019
5 Reads

Rapid decline of renal function in patients with type 2 diabetes with heavy proteinuria: a report of three cases.

BMC Nephrol 2019 Jan 16;20(1):22. Epub 2019 Jan 16.

Department of Nephrology, Serdang Hospital, 43400, Seri Kembangan, Selangor, Malaysia.

Background: Although there is a large volume of literature regarding the definition and epidemiology of. Type 2 diabetes nephropathy (T2DN). There has been a paucity of data focused on the rate of transition of T2 DN. Read More

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http://dx.doi.org/10.1186/s12882-019-1203-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335779PMC
January 2019
2 Reads
1.520 Impact Factor

Identification of young adults at risk of an accelerated loss of kidney function in an area affected by Mesoamerican nephropathy.

BMC Nephrol 2019 Jan 16;20(1):21. Epub 2019 Jan 16.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Background: After two-years of follow-up of 263 apparently healthy 18- to 30-year-old men in communities affected by Mesoamerican nephropathy (MeN), we identified three distinct case groups: a subgroup with (i) established renal dysfunction (case-group 1); individuals with (ii) a rapid decline in kidney function (case-group 2); and individuals with (iii) stable kidney function (non-cases). This paper investigates whether local tests are potentially useful for the timely identification of these case groups.

Methods: Creatinine levels were measured in local laboratories every six months for two years. Read More

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http://dx.doi.org/10.1186/s12882-018-1193-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335797PMC
January 2019
1 Read

Serum 25-Hydroxyvitamin D were associated with higher risk of both albuminuria and impaired GFR incidence: a cohort study based on CLHLS study.

BMC Nephrol 2019 Jan 15;20(1):20. Epub 2019 Jan 15.

Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National clinical research center for geriatrics diseases, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.

Background: This study aimed to examine the relationship between 25-hyfromxyvitamin D (25OHD) and chronic kidney disease (CKD) incidence.

Methods: All the elderly who had participated both in the 2011-2012 survey and 2014 survey in the Chinese Longitudinal Healthy Longevity Survey (CLHLS), and have biomarker data were included in the analysis. We studied those without CKD with complete data at 2011-2012 waves. Read More

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http://dx.doi.org/10.1186/s12882-019-1202-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332878PMC
January 2019
6 Reads

Serum uric acid and cardiovascular mortality in chronic kidney disease: a meta-analysis.

BMC Nephrol 2019 Jan 14;20(1):18. Epub 2019 Jan 14.

Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.

Background: Conflicting results have been reported from studies evaluating serum uric acid (SUA) levels as an independent risk factor for cardiovascular mortality in patients with chronic kidney disease (CKD).

Methods: We systematically searched MEDLINE, Web of Science, and bibliographies of retrieved articles to identify studies reporting on the association between SUA levels and cardiovascular mortality in patients with CKD. Random-effects models were used to calculate the pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI). Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1143-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330757PMC
January 2019
3 Reads

Bilateral renal artery stenosis as a cause of refractory intradialytic hypertension in a patient with end stage renal disease.

BMC Nephrol 2019 Jan 14;20(1):19. Epub 2019 Jan 14.

Section of Nephrology, Department of Medicine, Regina General Hospital, 1440, 14th Avenue, Regina, S4P 0W5, Canada.

Background: We report a 61-year-old female with end-stage renal disease (ESRD) secondary to polycystic kidney disease (PKD) complicated by intradialytic hypertension (IDH). Increased sympathetic drive leading to increased stroke volume and/or vasoconstriction with an inappropriate increase in peripheral vascular resistance (PVR) has been postulated to be the cause of IDH.

Case Presentation: Attempts to control her blood pressure by reducing her goal weight; increasing dialysis times/ frequency and decreasing her sodium concentrate in the dialysis fluid were unsuccessful. Read More

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http://dx.doi.org/10.1186/s12882-018-1191-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332586PMC
January 2019
2 Reads

Embolization of high-output idiopathic renal arteriovenous fistula primarily using an atrial septal defect occluder via venous access: a case report.

BMC Nephrol 2019 Jan 11;20(1):15. Epub 2019 Jan 11.

Department of Intervention, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Background: The case report is to evaluate the efficacy and safety of embolization of a high-output idiopathic renal arteriovenous fistula (IRAVF) with an atrial septal defect occluder (ASDO) via venous access.

Case Presentation: A 57-year-old male diagnosed with high-output IRAVF received embolization with an ASDO via renal venous access and compact occlusion with 3 vascular plugs and a detachable elastic coil. The IRAVF was successfully occluded. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1200-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329067PMC
January 2019
9 Reads
1.520 Impact Factor

Renal-limited thrombotic microangiopathy after switching from bevacizumab to ramucirumab: a case report.

BMC Nephrol 2019 Jan 11;20(1):14. Epub 2019 Jan 11.

Department of Nephrology, Shizuoka General Hospital, Shizuoka, 420-8527, Japan.

Background: It is well known that vascular endothelial growth factor (VEGF) inhibitors can cause proteinuria. The incidence of proteinuria is high for bevacizumab, a humanized monoclonal antibody directed against VEGF, but the range of proteinuria rarely becomes nephrotic (2.2% occurrence according to a meta-analysis). Read More

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http://dx.doi.org/10.1186/s12882-018-1194-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329058PMC
January 2019
2 Reads

Process based quality improvement using a continuous renal replacement therapy dashboard.

BMC Nephrol 2019 Jan 11;20(1):17. Epub 2019 Jan 11.

Division of Critical Care Medicine, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, 30322, USA.

Background: The prevalence of continuous renal replacement therapy (CRRT) utilization in critically ill patients with acute kidney is increasing. In comparison to published and on-going trials attempting to answer questions surrounding the optimal timing of CRRT initiation, anticoagulation, and modality, a paucity of literature describes the quality of the therapy delivered.

Methods: We conducted a single-center process improvement project to determine if a methodology to assess the quality of CRRT delivery could lead to improvement in CRRT delivery outcomes. Read More

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http://dx.doi.org/10.1186/s12882-018-1195-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330391PMC
January 2019
1 Read