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    3774 results match your criteria BMC Musculoskeletal Disorders[Journal]

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    Biomechanical study of isolated radial head dislocation.
    BMC Musculoskelet Disord 2017 Nov 21;18(1):470. Epub 2017 Nov 21.
    Department of Orthopedic Surgery, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara Prefecture, Japan.
    Background: Isolated radial head dislocation is a rare injury with an unclear pathomechanism, and the treatment is controversial. The purpose of the present study was to investigate the biomechanical contributions of the annular ligament, quadrate ligament, interosseous membrane, and annular ligament reconstructions to proximal radioulnar joint stability.

    Methods: Five fresh frozen cadaveric upper extremities were amputated above the elbow and solidly fixed on a customized jig. Read More

    Shoulder MRI features with clinical correlations in subacromial pain syndrome: a cross-sectional and prognostic study.
    BMC Musculoskelet Disord 2017 Nov 21;18(1):469. Epub 2017 Nov 21.
    Department of Physical Medicine and Rehabilitation, Oslo University Hospital HF, Ullevaal, Postboks 4956 Nydalen, 0424, Oslo, Norway.
    Background: Previous studies on shoulder patients have suggested that the prevalence of rotator cuff or bursa abnormalities are weakly related to symptoms and that similar findings are often found in asymptomatic persons. In addition, it is largely unknown whether structural changes identified by magnetic resonance imaging (MRI) affect outcome after treatment for shoulder pain. The purpose of this study was therefore to evaluate the presence of structural changes on MRI in patients with subacromial pain syndrome and to determine to what extent these changes are associated with symptoms and predict outcome after treatment (evaluated by the Shoulder Pain and Disability Index (SPADI)). Read More

    A new multiple trauma model of the mouse.
    BMC Musculoskelet Disord 2017 Nov 21;18(1):468. Epub 2017 Nov 21.
    Department of Trauma Surgery, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
    Background: Blunt trauma is the most frequent mechanism of injury in multiple trauma, commonly resulting from road traffic collisions or falls. Two of the most frequent injuries in patients with multiple trauma are chest trauma and extremity fracture. Several trauma mouse models combine chest trauma and head injury, but no trauma mouse model to date includes the combination of long bone fractures and chest trauma. Read More

    Quadriceps force and anterior tibial force occur obviously later than vertical ground reaction force: a simulation study.
    BMC Musculoskelet Disord 2017 Nov 18;18(1):467. Epub 2017 Nov 18.
    Faculty of Health Sciences, Hokkaido University, North 12, West 5, Kitaku, Sapporo, 060-0812, Japan.
    Background: Although it is well known that quadriceps force generates anterior tibial force, it has been unclear whether quadriceps force causes great anterior tibial force during the early phase of a landing task. The purpose of the present study was to examine whether the quadriceps force induced great anterior tibial force during the early phase of a landing task.

    Methods: Fourteen young, healthy, female subjects performed a single-leg landing task. Read More

    The patterns of loss of correction after posterior wedge osteotomy in ankylosing spondylitis-related thoracolumbar kyphosis: a minimum of five-year follow-up.
    BMC Musculoskelet Disord 2017 Nov 17;18(1):465. Epub 2017 Nov 17.
    Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Zhongshan Rd 321, Nanjing, 210008, China.
    Background: Short-term studies have demonstrated good surgical outcomes after pedicle subtraction osteotomy (PSO) in ankylosing spondylitis (AS) patients, but there is a paucity of literature focused on middle-term results, especially regarding patterns of loss of correction. The objective of this study is to assess the durability of surgical outcomes and the patterns of loss of correction in thoracolumbar kyphosis secondary to AS following lumbar PSO with over 5-year follow-up.

    Methods: We performed a retrospective review of 155 consecutive AS patients undergoing lumbar PSO from January 2001 to December 2011. Read More

    Individuals' explanations for their persistent or recurrent low back pain: a cross-sectional survey.
    BMC Musculoskelet Disord 2017 Nov 17;18(1):466. Epub 2017 Nov 17.
    School of Health and Rehabilitation Sciences, St Lucia, QLD, 4072, Australia.
    Background: Most people experience low back pain (LBP), and it is often ongoing or recurrent. Contemporary research knowledge indicates individual's pain beliefs have a strong effect on their pain experience and management. This study's primary aim was to determine the discourses (patterns of thinking) underlying people's beliefs about what causes their LBP to persist. Read More

    The impact of bone morphology on the outcome of the pivot shift test: a cohort study.
    BMC Musculoskelet Disord 2017 Nov 17;18(1):463. Epub 2017 Nov 17.
    Department of Orthopaedic Surgery, Centre Albert-Trillat, Hôpital de la Croix-Rousse, Lyon, France.
    Background: The presence of a positive pivot shift after surgical repair of the ACL is considered an important indicator of a failed reconstruction. The ability to predict the result of a pivot shift test after an ACL reconstruction using variables that can be measured prior to surgery could provide an indication of which patients may be at-risk of a poor surgical outcome.The purpose of this study was to determine whether structural characteristics of the femur and tibia, measured using plain radiographs, were associated with the result of the pivot shift test in unilateral ACL reconstructed patients. Read More

    Establishment of rat ankle post-traumatic osteoarthritis model induced by malleolus fracture.
    BMC Musculoskelet Disord 2017 Nov 17;18(1):464. Epub 2017 Nov 17.
    Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, China.
    Background: Malleolar fracture, which is present in 37-53% of human ankle osteoarthritis (OA), is the most common type of fracture in the ankle joint. In spite of this, no rat animal model has been developed for this type of injury to date. Here, we established a rat ankle post-traumatic OA (PTOA) model induced by malleolar fracture; this model will be useful in ankle OA research. Read More

    L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels.
    BMC Musculoskelet Disord 2017 Nov 16;18(1):462. Epub 2017 Nov 16.
    Department of Microbiology, School of Basic Medical Science, Wuhan University, 185 Donghu Road, Wuhan, Hubei, 430071, People's Republic of China.
    Background: To investigate the effects and potential mechanism of L161982 (a kind of EP4 antagonist) on the collagen-induced arthritis (CIA) mice model.

    Methods: The CIA mice model were first established by immunizing with Chicken Type II Collagen on DBA/1 mice. The CIA groups were administered once a day for 2 weeks with either 5 mg/kg L161982 by intraperitoneal injections (IP), 200 U celecoxib by intragastrical injections, or 100 μl PBS (IP). Read More

    Treatment of Charcot Neuroarthropathy and osteomyelitis of the same foot: a retrospective cohort study.
    BMC Musculoskelet Disord 2017 Nov 16;18(1):460. Epub 2017 Nov 16.
    Department of Orthopedics, Balgrist University Hospital, University of Zurich, Forchstrasse 340, -8008, Zurich, CH, Switzerland.
    Background: We evaluated treatment of osteomyelitis in the foot in the presence of Charcot neuroarthropathy, a devastating condition with progressive degeneration and joint destruction. We hypothesized that there was a difference in (1) amputation rate, (2) amputation level, (3) duration of antibiotic therapy, and (4) duration of immobilization for treatment of osteomyelitis within versus outside the Charcot zone.

    Methods: Forty patients (43 ft) diagnosed with Charcot neuroarthropathy and osteomyelitis of the same foot were retrospectively analyzed. Read More

    Structural effects of intra-articular TGF-β1 in moderate to advanced knee osteoarthritis: MRI-based assessment in a randomized controlled trial.
    BMC Musculoskelet Disord 2017 Nov 16;18(1):461. Epub 2017 Nov 16.
    Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA, USA.
    Background: To determine effects of allogeneic human chondrocytes expressing TGF-β1 (TG-C) on structural progression of MRI features of knee osteoarthritis over a 1 year period.

    Methods: This phase II randomized controlled trial of TG-C included patients with moderate to advanced osteoarthritis. Patients were randomized to receive an intraarticular 3:1 mixture of non-transduced allogeneic human chondrocytes and TG-C or placebo. Read More

    Differences in vertebral morphology around the apical vertebrae between neuromuscular scoliosis and idiopathic scoliosis in skeletally immature patients: a three-dimensional morphometric analysis.
    BMC Musculoskelet Disord 2017 Nov 16;18(1):459. Epub 2017 Nov 16.
    Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
    Background: Recent morphological analyses of vertebrae in patients with scoliosis have revealed three-dimensional (3D) deformities in the vertebral bodies. However, it remains controversial whether these deformities are secondary changes caused by asymmetrical vertebral loading or primary changes caused by aberrant asymmetrical vertebral growth. Furthermore, the difference in vertebral morphology between scoliosis with different pathogeneses remains unclear. Read More

    CT-based analysis of muscle volume and degeneration of gluteus medius in patients with unilateral hip osteoarthritis.
    BMC Musculoskelet Disord 2017 Nov 15;18(1):457. Epub 2017 Nov 15.
    Department of Orthopaedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
    Background: The gluteus medius (GMED) affects hip function as an abductor. We evaluated muscle volume and degeneration of the GMED by using CT-based analysis and assessed factors that affect hip abductor strength in patients with unilateral hip osteoarthritis (OA).

    Methods: We examined clinical and imaging findings associated with hip abductor strength in consecutive 50 patients with unilateral hip OA. Read More

    Treatment of genu valgum in children by means of temporary hemiepiphysiodesis using eight-plates: short-term findings.
    BMC Musculoskelet Disord 2017 Nov 15;18(1):456. Epub 2017 Nov 15.
    Department of Orthopaedic Surgery, Trauma Surgery and Plastic Surgery, University Hospital Leipzig, Liebigstrasse 20, D-04103, Leipzig, Germany.
    Background: Idiopathic genu valgum is a frequently diagnosed growth disorder in adolescence. Whenever the possibilities of conservative therapy have been exhausted, leg straightening by means of hemiepiphysiodesis has become the standard form of treatment. Because of their flexible screw-plate connection, eight-Plates have been reported in the literature to lead to lower complications regarding implant loosening and fracture compared to other implants. Read More

    Kinematic characterization of clinically observed aberrant movement patterns in patients with non-specific low back pain: a cross-sectional study.
    BMC Musculoskelet Disord 2017 Nov 15;18(1):455. Epub 2017 Nov 15.
    Physical Therapy & Rehabilitation Sciences Department, Drexel University, 1601 Cherry Street, Philadelphia, PA, 19102, USA.
    Background: Clinical observation of aberrant movement patterns during active forward bending is one criterion used to identify patients with non-specific low back pain suspected to have movement coordination impairment. The purpose of this study was to describe and quantify kinematic patterns of the pelvis and trunk using a dynamics systems approach, and determine agreement between clinical observation and kinematic classification.

    Method: Ninety-eight subjects performed repeated forward bending with clinical observation and kinematic data simultaneously collected. Read More

    Determinants of patient satisfaction following reconstructive shoulder surgery.
    BMC Musculoskelet Disord 2017 Nov 15;18(1):458. Epub 2017 Nov 15.
    Orthopaedic Department, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008, Zurich, Switzerland.
    Background: Obtaining patient satisfaction is a key goal of surgical treatment. It was the purpose of this study to identify pre-, peri- and postoperative factors determining patient satisfaction after shoulder surgery, quantify their relative importance and thereby allow the surgeon to focus on parameters, which will influence patient satisfaction.

    Methods: We retrospectively reviewed 505 patients, who underwent either rotator cuff repair (n = 216) or total shoulder arthroplasty (n = 289). Read More

    Are paraspinous intramuscular injections of botulinum toxin a (BoNT-A) efficient in the treatment of chronic low-back pain? A randomised, double-blinded crossover trial.
    BMC Musculoskelet Disord 2017 Nov 15;18(1):454. Epub 2017 Nov 15.
    Service de Médecine Physique et de Réadaptation, CHU de Bordeaux, 33076, Bordeaux, France.
    Background: Treatment for patients with chronic low-back pain (LBP) is a public health issue. Intramuscular injections of botulinum toxin A (BoNT-A) have shown an analgesic effect on LBP in two previous randomized controlled studies. The objective of the study was to verify the efficacy of paravertebral injections of BoNT-A in patients with LBP. Read More

    Assessment of success of the Ponseti method of clubfoot management in sub-Saharan Africa: a systematic review.
    BMC Musculoskelet Disord 2017 Nov 15;18(1):453. Epub 2017 Nov 15.
    International Centre for Evidence in Disability, London School of Hygiene & Tropical Medicine, London, UK.
    Background: Clubfoot is one of the most common congenital deformities affecting mobility. It leads to pain and disability if untreated. The Ponseti method is widely used for the correction of clubfoot. Read More

    Association between sarcopenia and low back pain in local residents prospective cohort study from the GAINA study.
    BMC Musculoskelet Disord 2017 Nov 15;18(1):452. Epub 2017 Nov 15.
    Department of Orthopedic Surgery,Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan.
    Background: Low back pain (LBP) is one of the most common ailments that people experience in their lifetime. On the other hands, Sarcopenia also leads to several physical symptoms and contributes to reducing the quality of life of elderly people.The purpose of this study is to investigate the association between sarcopenia and low back pain among the general population. Read More

    Variations in sagittal locations of anterior cruciate ligament tibial footprints and their association with radiographic landmarks: a human cadaveric study.
    BMC Musculoskelet Disord 2017 Nov 14;18(1):448. Epub 2017 Nov 14.
    Department of Orthopaedic Surgery, Seoul National University Boramae Hospital, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, South Korea.
    Background: This cadaveric study aimed to demonstrate variation of the anterior cruciate ligament (ACL) tibial attachment in the sagittal plane, and to analyze the radiographic landmarks which predict the sagittal location of the ACL tibial attachment.

    Methods: In 20 cadaveric knees, native ACLs were removed and the centers of the ACL tibial and femoral attachments were marked with metal pins. Full extension lateral radiographs were then obtained in each cadaveric knee. Read More

    Compression-rate-dependent nonlinear mechanics of normal and impaired porcine knee joints.
    BMC Musculoskelet Disord 2017 Nov 14;18(1):447. Epub 2017 Nov 14.
    Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive, N.W, Calgary, AB, T2N 1N4, Canada.
    Background: The knee joint performs mechanical functions with various loading and unloading processes. Past studies have focused on the kinematics and elastic response of the joint with less understanding of the rate-dependent load response associated with viscoelastic and poromechanical behaviors.

    Methods: Forty-five fresh porcine knee joints were used in the present study to determine the loading-rate-dependent force-compression relationship, creep and relaxation of normal, dehydrated and meniscectomized joints. Read More

    Percutaneous medial hemi-epiphysiodesis using a transphyseal screw for caput valgum associated with developmental dysplasia of the hip.
    BMC Musculoskelet Disord 2017 Nov 14;18(1):451. Epub 2017 Nov 14.
    Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.
    Background: The purpose of this study was to evaluate the radiologic outcome of percutaneous medial hemi-epiphysiodesis using a transphyseal screw for the management of caput valgum associated with developmental dysplasia of the hip (DDH).

    Methods: Eighteen hips (18 patients) having caput valgum treated with screw hemi-epiphysiodesis were followed for more than 2 years, and were included in this study. The mean age at the time of the index operation was 8. Read More

    Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint.
    BMC Musculoskelet Disord 2017 Nov 14;18(1):450. Epub 2017 Nov 14.
    Orthopaedic Department, Ruijin Hospital, Ruijin Er Road No.197, Shanghai, 200025, China.
    Background: Diffused-type giant cell tumor(Dt-GCT) is a rare, aggressive disorder of the joint synovium, bursa and tendon sheaths. Osseous erosions and subchondral cysts may develop as the result of synovium infiltration in Dt-GCT. We present a retrospective study of a series of patients who are diagnosed with Dt-GCT about the ankle joint, there clinical outcome is evaluated in this study. Read More

    Comparison of semi-quantitative and quantitative dynamic contrast-enhanced MRI evaluations of vertebral marrow perfusion in a rat osteoporosis model.
    BMC Musculoskelet Disord 2017 Nov 14;18(1):446. Epub 2017 Nov 14.
    Department of Radiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
    Background: This study aims to investigate the technical feasibility of semi-quantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the assessment of longitudinal changes of marrow perfusion in a rat osteoporosis model, using bone mineral density (BMD) measured by micro-computed tomography (micro-CT) and histopathology as the gold standards.

    Methods: Fifty rats were randomly assigned to the control group (n=25) and ovariectomy (OVX) group whose bilateral ovaries were excised (n=25). Semi-quantitative and quantitative DCE-MRI, micro-CT, and histopathological examinations were performed on lumbar vertebrae at baseline and 3, 6, 9, and 12 weeks after operation. Read More

    Diagnostic validity and triage concordance of a physiotherapist compared to physicians' diagnoses for common knee disorders.
    BMC Musculoskelet Disord 2017 Nov 14;18(1):445. Epub 2017 Nov 14.
    School of Rehabilitation, Faculty of Medicine, University of Montreal, Montreal, QC, Canada.
    Background: Emergence of more autonomous roles for physiotherapists warrants more evidence regarding their diagnostic capabilities. Therefore, we aimed to evaluate diagnostic and surgical triage concordance between a physiotherapist and expert physicians and to assess the diagnostic validity of the physiotherapist's musculoskeletal examination (ME) without imaging.

    Methods: This is a prospective diagnostic study where 179 consecutive participants consulting for any knee complaint were independently diagnosed and triaged by two evaluators: a physiotherapist and one expert physician (orthopaedic surgeons or sport medicine physicians). Read More

    Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage.
    BMC Musculoskelet Disord 2017 Nov 14;18(1):449. Epub 2017 Nov 14.
    Division of Orthopaedic Surgery, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
    Background: ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stage osteoarthritis. To determine the effect of hemoglobin (Hb) on the ability of synovial tissues to produce ADAMTS family members, we examined the influence of Hb by synovial cells in an in vitro experimental system. Read More

    Knee arthrodesis versus above-the-knee amputation after septic failure of revision total knee arthroplasty: comparison of functional outcome and complication rates.
    BMC Musculoskelet Disord 2017 Nov 13;18(1):443. Epub 2017 Nov 13.
    BG Unfallklinik Murnau, Prof. Küntscher Str. 8, Murnau, 82418, Germany.
    Background: After septic failure of total knee arthroplasty (TKA) and multiple revision operations resulting in impaired function, bone and/or soft-tissue damage a reconstruction with a revision arthroplasty might be impossible. Salvage procedures to regain mobility and quality of life are an above-the-knee amputation or knee arthrodesis. The decision process for the patient and surgeon is difficult and data comparing arthrodesis versus amputation in terms of function and quality of life are scarce. Read More

    Can hybrid hyaluronic acid represent a valid approach to treat rizoarthrosis? A retrospective comparative study.
    BMC Musculoskelet Disord 2017 Nov 13;18(1):444. Epub 2017 Nov 13.
    Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci 1, 53100, Siena, Italy.
    Background: Osteoarthritis (OA) of the trapeziometacarpal joint (TMJ) is a disabling condition with a significant impact on quality of life. The optimal management of hand OA requires a combination of non-pharmacological and pharmacological treatments that include intra-articular (i.a. Read More

    Topical zoledronic acid decreases micromotion induced bone resorption in a sheep arthroplasty model.
    BMC Musculoskelet Disord 2017 Nov 13;18(1):441. Epub 2017 Nov 13.
    Orthopaedic Research Laboratory, Department of Orthopaedics, Aarhus University Hospital, Norrebrogade 44, Building 1A, DK-8000, Aarhus, Denmark.
    Background: Initial micromotion of a total hip replacement is associated with aseptic loosening. The use of bisphosphonates could be one way to reduce peri-implant bone resorption induced by micromotion. Bisphosphonates compounds are inhibitors of bone resorption. Read More

    Posterior shoulder dislocation with associated reverse Hill-Sachs lesion: treatment options and functional outcome after a 5-year follow up.
    BMC Musculoskelet Disord 2017 Nov 13;18(1):442. Epub 2017 Nov 13.
    Department for Traumatology and Reconstructive Surgery, BG Trauma Center Tübingen, University of Tübingen, Schnarrenbergstr 95, 72076, Tuebingen, Germany.
    Background: The current study describes several surgical techniques for the treatment of the reverse Hill - Sachs lesion after posterior shoulder dislocation; we also aimed to present long term results followed for a minimum of five years.

    Methods: This study is a prospective case series of 17 patients who were treated in our clinic between 2008 and 2011. Patients with a defect size smaller than 25% of the articular surface were treated conservatively. Read More

    Concomitant glenohumeral pathologies in high-grade acromioclavicular separation (type III - V).
    BMC Musculoskelet Disord 2017 Nov 10;18(1):439. Epub 2017 Nov 10.
    Center of Orthopaedics and Traumatology, University Hospital Marburg, Baldingerstrasse, 35033, Marburg, Germany.
    Background: Acromioclavicular joint (ACJ) dislocations are common injuries of the shoulder associated with physical activity. The diagnosis of concomitant injuries proves complicated due to the prominent clinical symptoms of acute ACJ dislocation. Because of increasing use of minimally invasive surgery techniques concomitant pathologies are diagnosed more often than with previous procedures. Read More

    Dyslipidaemia for patients with low-energy femoral neck fractures after the treatment of cancellous screws: a retrospective study with a 3-year minimum follow-up.
    BMC Musculoskelet Disord 2017 Nov 10;18(1):440. Epub 2017 Nov 10.
    Department of Orthopaedics, Jinshan Hospital, Fudan University, Longhang Road No. 1508, Jinshan District, Shanghai City, 201508, China.
    Background: Avascular necrosis of the femoral head (AVNFH) occurs infrequently following femoral neck fracture. The association between AVNFH and dyslipidaemia remains controversial. Although major risk factors for AVNFH have been proposed, most of them remain under discussion. Read More

    Analysis of medical service use of knee osteoarthritis and knee meniscal and ligament injuries in Korea: a cross-sectional study of national patient sample data.
    BMC Musculoskelet Disord 2017 Nov 10;18(1):438. Epub 2017 Nov 10.
    Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, 858 Eonju-ro, Gangnam-gu, Seoul, Republic of Korea.
    Background: Osteoarthritis (OA) and meniscal and ligament injuries of the knee are the two most common knee disorders in Korea. The aim of this study was to analyze the demographic characteristics, medical service use and related costs for these disorders, and the results are expected to help inform practitioners, researchers, and policy-makers.

    Methods: The present study aimed to evaluate incidence and patient characteristics, and to assess current medical service use, usual care, and medical expenses of knee disorders by analyzing 2014 national patient sample data from the Korean Health Insurance Review and Assessment Service. Read More

    Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear.
    BMC Musculoskelet Disord 2017 Nov 9;18(1):436. Epub 2017 Nov 9.
    Department of Orthopaedics, University of Maryland School of Medicine, AHB, Rm 540, 100 Penn St., Baltimore, MD, 21201, USA.
    Background: Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed supraspinatus force and susceptibility to injury in the rat model of RTC tear, and compared these functional changes to histopathology of the muscle.

    Methods: Unilateral RTC tears were induced in male rats via tenotomy of the supraspinatus and infraspinatus. Read More

    p21(-/-) mice exhibit enhanced bone regeneration after injury.
    BMC Musculoskelet Disord 2017 Nov 9;18(1):435. Epub 2017 Nov 9.
    McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
    Background: p21((WAF1/CIP1/SDI1)), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair. Studies on p21((-/-)) knockout mice have demonstrated results that vary from complete regeneration and healing of tissue to attenuated healing. There have however been no studies that have evaluated the role of p21 inhibition in bone healing and remodeling. Read More

    Frequency of acute cervical and lumbar pathology in common types of motor vehicle collisions: a retrospective record review.
    BMC Musculoskelet Disord 2017 Nov 9;18(1):437. Epub 2017 Nov 9.
    Pacific Pain & Regenerative Medicine, 20301 Southwest Birch Street, Suite 102, Newport Beach, CA, 92660, USA.
    Background: There are more than 5 million motor vehicle collisions annually in the United States, resulting in more than 2 million injured occupants. The most common types of collisions are head-on impacts, rear-ends, side-swipes, and t-bones, whilst the most common injury sites are the cervical and lumbar spine. The purpose of this retrospective record review was to examine the differences in frequency of cervical and lumbar pathology across and between these common collision types. Read More

    Increased stiffness of median nerve in systemic sclerosis.
    BMC Musculoskelet Disord 2017 Nov 7;18(1):434. Epub 2017 Nov 7.
    Marmara University Hospital, Rheumatology Department, Istanbul, Turkey.
    Background: Systemic sclerosis can affect peripheral nerves, but the extent and the nature of this involvement are not well defined. The aim of this study is to compare the sonoelastrographic measurements of median nerves in systemic sclerosis (SSC), idiopathic carpal tunnel syndrome (CTS) and healthy individuals.

    Methods: The clinical, electrophysiological and ultrasonographic assessments were done. Read More

    Co-expression of 1α-hydroxylase and vitamin D receptor in human articular chondrocytes.
    BMC Musculoskelet Disord 2017 Nov 6;18(1):432. Epub 2017 Nov 6.
    Bone and joint research group, Institute of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
    Background: The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active hormone 1α,25(OH)2D3, namely 1α-hydroxylase (CYP27B1). Any putative effects of vitamin D on chondrocytes were also explored.

    Methods: Cartilage from human osteoarthritic knee joints, cultured chondrocytes and cells grown in 3D spheroids were examined for the expression of VDR and 1α-hydroxylase by PCR, Western blots and immunolabelling. Read More

    Effectiveness of a theory-based multicomponent intervention (Movement Coaching) on the promotion of total and domain-specific physical activity: a randomised controlled trial in low back pain patients.
    BMC Musculoskelet Disord 2017 Nov 6;18(1):431. Epub 2017 Nov 6.
    Center for Health through Sport and Movement, German Sport University Cologne, 50933, Cologne, Germany.
    Background: The promotion of physical activity is a major field in rehabilitation and health promotion but evidence is lacking on what method or strategy works best. Ensuing from this research gap, the present study compared the effectiveness of a comprehensive theory based multicomponent intervention (Movement Coaching) to a low intensity intervention in low back pain patients.

    Methods: A monocenter randomized controlled trial with three measuring points (T0 = baseline, T1 = six month follow-up, T2 = twelve month follow-up) was conducted. Read More

    Open subpectoral biceps tenodesis in patients over 65 does not result in an increased rate of complications.
    BMC Musculoskelet Disord 2017 Nov 6;18(1):430. Epub 2017 Nov 6.
    Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA.
    Background: Long head biceps tendon pathology is a common cause of anterior shoulder pain and is often associated with other shoulder conditions, such as rotator cuff tears and osteoarthritis. It is well accepted that older patients are at increased risk for major and minor peri- and postoperative complications. The purpose of this study is to investigate patients over 65 years old who underwent subpectoral biceps tenodesis and compare the complication rates of this group to those of patients younger than 65 years old. Read More

    High-impact exercise in adulthood and vertebral dimensions in midlife - the Northern Finland Birth Cohort 1966 study.
    BMC Musculoskelet Disord 2017 Nov 6;18(1):433. Epub 2017 Nov 6.
    Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, 90014, Oulu, Finland.
    Background: Vertebral size and especially cross-sectional area (CSA) are independently associated with vertebral fracture risk. Previous studies have suggested that physical activity and especially high-impact exercise may affect vertebral strength. We aimed to investigate the association between high-impact exercise at 31 and 46 years of age and vertebral dimensions in midlife. Read More

    Expression of adiponectin in the subchondral bone of lumbar facet joints with different degrees of degeneration.
    BMC Musculoskelet Disord 2017 Nov 3;18(1):427. Epub 2017 Nov 3.
    Department of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
    Background: Osteoarthritis research has been most commonly performed in the setting of the articular cartilage of the knee. To the best of our knowledge, no studies have evaluated the role of adiponectin in osteoarthritis of the lumbar facet joint (FJOA). Therefore, in this study, we explored whether adiponectin was expressed in the lumbar facet joints and evaluated the role of adiponectin in FJOA. Read More

    An evaluation of the potential consequences of drilling titanium and tantalum implants during surgery - a pilot study.
    BMC Musculoskelet Disord 2017 Nov 3;18(1):426. Epub 2017 Nov 3.
    Department of Angiology, Medical University of Łódź, ul. Narutowicza 60, 90-136, Łódź, Poland.
    Background: The aim of the study was to evaluate the potential consequences of drilling titanium alloy (Ti) and tantalum (Ta) implants.

    Methods: During an in vitro study, four holes were made in each of two spatially porous trabecular implants: one Ta and the other Ti alloy (Ti-6Al-7Nb). The weight and the volume of particles produced during the drilling were then measured using a Radwag XA 110/2X (USA) laboratory balance. Read More

    Associated factors with functional disability and health-related quality of life in Chinese patients with gout: a case-control study.
    BMC Musculoskelet Disord 2017 Nov 3;18(1):429. Epub 2017 Nov 3.
    Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China.
    Background: Gout is a painful, inflammatory disease that may cause decreased function and health-related quality of life (HRQoL). Limited study did not take the influence of gout characteristics and anxiety on HRQoL into consideration and there are no studies associated with functional disability in individuals with gout from China. This study aims to investigate the related factors of functional disability and HRQoL in gout patients recruited from China. Read More

    Efficacy of nerve growth factor antibody in a knee osteoarthritis pain model in mice.
    BMC Musculoskelet Disord 2017 Nov 3;18(1):428. Epub 2017 Nov 3.
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Background: Nerve growth factor (NGF) is not only an important factor in nerve growth but also a major contributor to the production of inflammation. It has been reported that inhibiting NGF could reduce several types of pain in several animal models. Here, we aimed to clarify the efficacy of NGF antibody in a knee osteoarthritis (OA) pain model in mice. Read More

    Prevalence of musculoskeletal disorders among school teachers from urban and rural areas in Chuquisaca, Bolivia: a cross-sectional study.
    BMC Musculoskelet Disord 2017 Oct 27;18(1):425. Epub 2017 Oct 27.
    Institute for Occupational, Social and Environmental Medicine, Occupational and Environmental Epidemiology & Net Teaching Unit, University Hospital Munich (LMU), Munich. Ziemssenstr. 1, 80336, Munich, Germany.
    Background: Musculoskeletal disorders (MSD) are important health problems in working populations. The study aimed to determine the prevalence of MSD among school teachers from urban and rural areas in Chuquisaca, Bolivia.

    Methods: A cross-sectional study was conducted in 60 randomly selected schools. Read More

    Design of the SALT Osteoporosis Study: a randomised pragmatic trial, to study a primary care screening and treatment program for the prevention of fractures in women aged 65 years or older.
    BMC Musculoskelet Disord 2017 Oct 27;18(1):424. Epub 2017 Oct 27.
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam Public Health research institute, Amsterdam, The Netherlands.
    Background: Several drugs have become available for the treatment of osteoporosis. However, screening and treatment of patients with a high fracture risk is currently not recommended in the Netherlands, because the effectiveness of bone sparing drugs has not been demonstrated in the general primary care population. Here we describe the design of the SALT Osteoporosis study, which aims to examine whether the screening and treatment of older, female patients in primary care can reduce fractures, in comparison to usual care. Read More

    Effects of Osteoglycin (OGN) on treating senile osteoporosis by regulating MSCs.
    BMC Musculoskelet Disord 2017 Oct 26;18(1):423. Epub 2017 Oct 26.
    Department of Endocrinology and Metabolism, Shanghai General Hospital of Nanjing Medical University, 100 Haining Road, Shanghai, 200080, China.
    Background: Significant amount of bone mass is lost during the process of aging due to an imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption in bone marrow microenvironment, which leads to net bone loss in the aging population, resulting in the pathogenesis of osteoporosis.

    Methods: Firstly, differences in proliferative capacity of adipocyte or adipogenic differentiation in mouse mesenchymal stem cells (MMSCs) and senile mouse model-derived bone marrow mesenchymal stem cells (SMMSCs), as well as mRNA expression of OGN and PPARγ2 were observed. Secondly, osteogenic abilities of MMSCs and SMMSCs treated with rosiglitazone (a PPARγ2 agonist) to induce osteogenic changes were observed, and negative correlation of PPARγ2 with OGN was evaluated. Read More

    Prognostic factors for recovery following acute lateral ankle ligament sprain: a systematic review.
    BMC Musculoskelet Disord 2017 Oct 23;18(1):421. Epub 2017 Oct 23.
    Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
    Background: One-third of individuals who sustain an acute lateral ankle ligament sprain suffer significant disability due to pain, functional instability, mechanical instability or recurrent sprain after recovery plateaus at 1 to 5 years post injury. The identification of early prognostic factors associated with poor recovery may provide an opportunity for early-targeted intervention and improve outcome.

    Methods: We performed a comprehensive search of AMED, EMBASE, Psych Info, CINAHL, SportDiscus, PubMed, CENTRAL, PEDro, OpenGrey, abstracts and conference proceedings from inception to September 2016. Read More

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