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    3924 results match your criteria BMC Musculoskeletal Disorders[Journal]

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    The association between subgroups of MRI findings identified with latent class analysis and low back pain in 40-year-old Danes.
    BMC Musculoskelet Disord 2018 Feb 20;19(1):62. Epub 2018 Feb 20.
    Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
    Background: Research into the clinical importance of spinal MRI findings in patients with low back pain (LBP) has primarily focused on single imaging findings, such as Modic changes or disc degeneration, and found only weak associations with the presence of pain. However, numerous MRI findings almost always co-exist in the lumbar spine and are often present at more than one lumbar level. It is possible that multiple MRI findings are more strongly associated with LBP than single MRI findings. Read More

    Genetic polymorphisms in bone morphogenetic protein receptor type IA gene predisposes individuals to ossification of the posterior longitudinal ligament of the cervical spine via the smad signaling pathway.
    BMC Musculoskelet Disord 2018 Feb 20;19(1):61. Epub 2018 Feb 20.
    Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, 100069, China.
    Background: The present study investigated the molecular mechanisms underlying the 4A > C and -349C > T single nucleotide polymorphisms (SNPs) in bone morphogenetic protein receptor type IA (BMPR-IA) gene, which significantly associated with the occurrence and the extent of ossification of the posterior longitudinal ligament (OPLL) in the cervical spine.

    Methods: The SNPs in BMPR-IA gene were genotyped, and the association with the occurrence and severity of OPLL were evaluated in 356 OPLL patients and 617 non-OPLL controls. In stably transfected mouse embryonic mesenchymal stem cells (C3H10T1/2), the expression levels of the BMPR-IA gene and Smad4 protein as well as phosphorylated Smad1/5/8 were detected by Western blotting. Read More

    Tranexamic acid in total shoulder arthroplasty and reverse shoulder arthroplasty: a systematic review and meta-analysis.
    BMC Musculoskelet Disord 2018 Feb 17;19(1):60. Epub 2018 Feb 17.
    Department of Orthopedic Surgery, College of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea.
    Background: The effects of tranexamic acid (TXA) in the setting of shoulder arthroplasty are unclear. The objective of this study was to examine the effects of TXA in reducing the need for blood transfusions and blood loss in patients undergoing primary total shoulder arthroplasty (TSA) and reverse total shoulder arthroplasty (RTSA).

    Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and retrospective cohort studies (RCS) that compared outcomes of patients who did and did not receive TXA during TSA or RTSA. Read More

    Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial.
    BMC Musculoskelet Disord 2018 Feb 17;19(1):59. Epub 2018 Feb 17.
    Arthritis Research UK Primary Care Centre, Research Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK.
    Background: Exercise interventions improve clinical outcomes of pain and function in adults with knee pain due to osteoarthritis and higher levels of physical activity are associated with lower severity of pain and higher levels of physical functioning in older adults with knee osteoarthritis in cross-sectional studies. However, to date no studies have investigated if change in physical activity level during exercise interventions can explain clinical outcomes of pain and function. This study aimed to investigate if change in physical activity during exercise interventions is associated with future pain and physical function in older adults with knee pain. Read More

    Prevalence of adolescent physical activity-related injuries in sports, leisure time, and school: the National Physical Activity Behaviour Study for children and Adolescents.
    BMC Musculoskelet Disord 2018 Feb 15;19(1):58. Epub 2018 Feb 15.
    Tampere Research Center of Sports Medicine, UKK Institute for Health Promotion Research, P.O. BOX 30, 33501, Tampere, Finland.
    Background: The purpose of this study was to investigate the prevalence of adolescent physical activity-related injuries in sports club activities, leisure time physical activity and school-based physical activity. The secondary aim was to investigate the differences in the prevalence of physical activity -related injuries between years 2014 and 2016. In addition, we set out to study the associations between age, sex and the frequency of physical activity and injury prevalence. Read More

    Parameters influencing hand grip strength measured with the manugraphy system.
    BMC Musculoskelet Disord 2018 Feb 14;19(1):54. Epub 2018 Feb 14.
    Clinic for Hand Surgery, Rhön Klinikum AG, Salzburger Leite 1, 97616, Bad Neustadt an der Saale, Germany.
    Background: This study aimed to determine whether sex, hand length and the individual training status affect hand strength and whether these measurements differ if they are recorded using the Jamar dynamometer or a new cylindrical measuring system.

    Methods: For this purpose, 152 healthy adults were examined using a new manugraphy measuring system (novel, Munich, Germany) comprising two measuring cylinders of different sizes and a Jamar electronic dynamometer with two grip positions corresponding approximately to the sizes of the cylinders. A descriptive analysis was performed as well as a correlation analysis using the Pearson correlation coefficient. Read More

    Effects of multilevel posterior ligament dissection after spinal instrumentation on adjacent segment biomechanics as a potential risk factor for proximal junctional kyphosis: a biomechanical study.
    BMC Musculoskelet Disord 2018 Feb 14;19(1):57. Epub 2018 Feb 14.
    Department of Trauma Surgery, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.
    Background: Spinous processes and posterior ligaments, such as inter- and supraspinous ligaments are often sacrificed either deliberately to harvest osseous material for final spondylodesis e.g. in deformity corrective surgery or accidentally after posterior spinal instrumentation. Read More

    Analysis of Total Knee Arthroplasty revision causes.
    BMC Musculoskelet Disord 2018 Feb 14;19(1):55. Epub 2018 Feb 14.
    University Center of Orthopaedics and Traumatology, University Medicine Carl Gustav Carus Dresden, TU Dresden, Fetscherst. 74, 01307, Dresden, Germany.
    Background: The number of revision Total Knee Arthroplasty (TKA) is rising in many countries. The aim of this study was the prospective assessment of the underlying causes leading to revision TKA in a tertiary care hospital and the comparison of those reasons with previously published data.

    Methods: In this study patients who had revision TKA between 2010 and 2015 were prospectively included. Read More

    The knitting community-based trial for older women with osteoarthritis of the hands: design and rationale of a randomized controlled trial.
    BMC Musculoskelet Disord 2018 Feb 14;19(1):56. Epub 2018 Feb 14.
    School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
    Background: The prevalence of hand osteoarthritis (HOA) has been reported to be higher amongst women over 50 years old (66%) compared to men of the same age (34%). Although exercise therapy has been shown effective in reducing symptoms and disability associated with HOA, adherence to treatment programs remains low. The primary objective of this RCT is to examine the effectiveness of a 12-week knitting program for morning stiffness (primary outcome) and pain relief (secondary outcome) 2 h post-wakening in females (aged 50 to 85 years old) with mild to moderate hand osteoarthritis (HOA). Read More

    A retrospective analysis of bone mineral status in patients requiring spinal surgery.
    BMC Musculoskelet Disord 2018 Feb 13;19(1):53. Epub 2018 Feb 13.
    Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestraße 59, 22529, Hamburg, Germany.
    Background: Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of bone mineral disorders.

    Methods: We retrospectively analyzed the bone mineral status of 144 patients requiring spinal surgery including bone mineral density by dual-energy X-ray absorptiometry (DXA) as well as laboratory data with serum levels of 25-hydroxyvitamin D (25-OH-D), parathyroid hormone, calcium, bone specific alkaline phosphate, osteocalcin, and gastrin. Read More

    3D analysis of Osteosyntheses material using semi-automated CT segmentation: a case series of a 4 corner fusion plate.
    BMC Musculoskelet Disord 2018 Feb 13;19(1):52. Epub 2018 Feb 13.
    Department of Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
    Backround: Scaphoidectomy and midcarpal fusion can be performed using traditional fixation methods like K-wires, staples, screws or different dorsal (non)locking arthrodesis systems. The aim of this study is to test the Aptus four corner locking plate and to compare the clinical findings to the data revealed by CT scans and semi-automated segmentation.

    Methods: This is a retrospective review of eleven patients suffering from scapholunate advanced collapse (SLAC) or scaphoid non-union advanced collapse (SNAC) wrist, who received a four corner fusion between August 2011 and July 2014. Read More

    Morphological characteristics of the posterior malleolar fragment according to ankle fracture patterns: a computed tomography-based study.
    BMC Musculoskelet Disord 2018 Feb 13;19(1):51. Epub 2018 Feb 13.
    Department of Orthopaedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University, 77, Sakju-ro, Chuncheoni-si, Gangwon-do, 200-704, Republic of Korea.
    Background: The posterior malleolar fragment (PMF) of an ankle fracture can have various shapes depending on the injury mechanism. The purpose of this study was to evaluate the morphological characteristics of the PMF according to the ankle fracture pattern described in the Lauge-Hansen classification by using computed tomography (CT) images.

    Methods: We retrospectively analyzed CT data of 107 patients (107 ankles) who underwent surgery for trimalleolar fracture from January 2012 to December 2014. Read More

    Comparison of screening strategies for prevalent vertebral fractures in South Korea: vertebral fracture assessment vs. spine radiography.
    BMC Musculoskelet Disord 2018 02 12;19(1):46. Epub 2018 Feb 12.
    Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222-1 wangsimni-ro, Seoundong-gu, Seoul, 133-792, Republic of Korea.
    Background: Vertebral Fracture Assessment (VFA) is a useful tool to detect the vertebral fracture (VF) with low cost and radiation exposure. We aimed to compare screening strategies including VFA and spine radiography (X-ray) for detecting VF in terms of clinical effectiveness, cost and radiation exposure.

    Methods: Three screening strategies: 1) X-ray following VFA, 2) VFA only, and 3) X-ray only were compared using a Markov model based on administrative data from South Korea in a population aged ≥50 years. Read More

    Effects of local treatment with and without sensorimotor and balance exercise in individuals with neck pain: protocol for a randomized controlled trial.
    BMC Musculoskelet Disord 2018 02 13;19(1):48. Epub 2018 Feb 13.
    Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
    Background: Impaired cervical joint position sense and balance are associated with neck pain. Specific therapeutic exercise and manual therapy are effective for improving neck pain and functional ability but their effects on joint position sense and balance impairments remain uncertain. Changes in the joint position sense and balance may need to be addressed specifically. Read More

    Protocol for the Individual Placement and Support (IPS) in Pain Trial: A randomized controlled trial investigating the effectiveness of IPS for patients with chronic pain.
    BMC Musculoskelet Disord 2018 02 13;19(1):47. Epub 2018 Feb 13.
    Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway.
    Background: Work disability involves large costs to the society as well as to the individual. Work disability is common among people with chronic pain conditions, yet few effective interventions exist. Individual Placement and Support (IPS) is an evidence-based work rehabilitation model originally developed to help people with severe mental illness obtain and maintain employment. Read More

    Safety and efficacy of platelet-rich plasma in treatment of carpal tunnel syndrome; a randomized controlled trial.
    BMC Musculoskelet Disord 2018 02 13;19(1):49. Epub 2018 Feb 13.
    Physical Medicine and Rehabilitation Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: Carpal tunnel syndrome is the most common peripheral entrapment neuropathy, for which conservative treatments are the first measures taken. However, these measures are not usually sufficient. Recently major attention has been drawn to platelet-rich plasma for its possible effects on axon regeneration and neurological recovery. Read More

    Impact of treatment strategy and physical performance on future knee-related self-efficacy in individuals with ACL injury.
    BMC Musculoskelet Disord 2018 02 13;19(1):50. Epub 2018 Feb 13.
    Department of Health Sciences, Lund University, Box 157, 221 00, Lund, Sweden.
    Background: In people with anterior cruciate ligament (ACL) injury, high self-efficacy facilitates recovery, indicated by improved muscle function, reduced knee symptoms and increased physical activity. Impact of treatment on future self-efficacy is however not well investigated. The aims of the study were to 1) investigate knee-related self-efficacy 6 years after acute ACL injury in patients treated with exercise therapy alone or in combination with either early or the option of delayed ACL reconstruction (ACLR), and 2) to investigate associations between single-leg physical performance at various time points after ACL injury and knee self-efficacy at 6 years after injury. Read More

    Risk factors for neck pain among forklift truck operators: a retrospective cohort study.
    BMC Musculoskelet Disord 2018 02 9;19(1):44. Epub 2018 Feb 9.
    Occupational and Environmental Medicine, and Department of Clinical and Experimental Medicine, Linköping University, Östergötland, 581 85, Linköping, Sweden.
    Background: No previous research has been performed into neck pain among forklift operators. This is a common complaint among these workers, who number around 150,000 in Sweden and six million in Europe. The aim of the study was to examine long-term exposure to unnatural neck positions among forklift operators as a risk factor for neck pain. Read More

    Anterior cruciate ligament reconstruction with quadriceps tendon-patellar bone allograft: matched case control study.
    BMC Musculoskelet Disord 2018 02 9;19(1):45. Epub 2018 Feb 9.
    Seoul National University Hospital, Seoul, Republic of Korea.
    Background: Quadriceps tendon-patellar bone (QTPB) autograft is an excellent graft option with good clinical outcome. Use of QTPB autografts have increased because they minimize donor-site morbidity including anterior knee pain, while providing adequate mechanical strength. Although, there were many clinical results about allografts that used in anterior cruciate ligament (ACL) reconstruction, it have never been reported about the clinical outcome of ACL reconstruction with QTPB allograft. Read More

    Osteoporosis knowledge and beliefs in diabetic patients: a cross sectional study from Palestine.
    BMC Musculoskelet Disord 2018 02 7;19(1):43. Epub 2018 Feb 7.
    Department of Physiology, Pharmacology and Toxicology, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
    Background: Osteoporosis is a potential metabolic complication of diabetes mellitus (DM). Therefore, patients with DM should have adequate osteoporosis knowledge and beliefs in order to get engaged in osteoporosis preventive behaviors. The objective of this study was to assess osteoporosis knowledge and beliefs among diabetic patients. Read More

    In-vivo study of osseointegration in Prestige LP cervical disc prosthesis.
    BMC Musculoskelet Disord 2018 02 7;19(1):42. Epub 2018 Feb 7.
    Department of Orthopedics, West China Hospital, Sichuan University, 37 Guoxue Road, Chengdu, Sichuan, 610041, China.
    Background: A study was designed to quantify the extent of porous osseointegration at the prosthesis-bone interface in the Prestige LP prosthesis containing a plasma-sprayed titanium coating.

    Methods: Using an anterior surgical approach, cervical disc arthroplasty was performed in 8 mature male goats at the C3-C4 segment, followed by implantation of the Prestige LP prosthesis. The vertebral specimens were examined using microcomputed tomograph for histomorphometric quantification, and proceeded by routine paraffin processing for histological observation. Read More

    Epidemiology of paediatric presentations with musculoskeletal problems in primary care.
    BMC Musculoskelet Disord 2018 02 6;19(1):40. Epub 2018 Feb 6.
    Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK.
    Background: Musculoskeletal disease is a common cause of morbidity, but there is a paucity of musculoskeletal research focusing on paediatric populations, particularly in primary care settings. In particular, there is limited information on population consultation frequency in paediatric populations, and frequency varies by age and sex. Few studies have examined paediatric musculoskeletal consultation frequency for different body regions. Read More

    Clinical and radiological outcomes of arthroscopically assisted cannulated screw fixation for tibial eminence fracture in children and adolescents.
    BMC Musculoskelet Disord 2018 02 6;19(1):41. Epub 2018 Feb 6.
    Department of Orthopaedic Surgery, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul, 03080, Republic of Korea.
    Background: The purpose of this study was to determine the efficacy and complications of arthroscopically assisted reduction and fixation with cannulated screws for tibial eminence fracture in skeletally immature patients.

    Methods: This was a retrospective case series study. Forty-eight patients who were skeletally immature at the time of tibial eminence fracture were treated in a tertiary children's hospital between May 2004 and August 2015. Read More

    Biomechanical effects of metastasis in the osteoporotic lumbar spine: A Finite Element Analysis.
    BMC Musculoskelet Disord 2018 02 5;19(1):38. Epub 2018 Feb 5.
    Biomechanics Laboratory, Division of Orthopaedic Research, Mayo Clinic, Rochester, MN, USA.
    Background: Cancer patients are likely to undergo osteoporosis as consequence of hormone manipulation and/or chemotherapy. Little is known about possible increased risk of fracture in this population. The aim of this study was to describe the biomechanical effect of a metastatic lesion in an osteoporotic lumbar spine model. Read More

    Serum and synovial fluid cytokine profiling in hip osteoarthritis: distinct from knee osteoarthritis and correlated with pain.
    BMC Musculoskelet Disord 2018 02 5;19(1):39. Epub 2018 Feb 5.
    McCaig Institute for Bone and Joint Health, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada.
    Background: Inflammation is associated with the onset and progression of osteoarthritis in multiple joints. It is well known that mechanical properties differ between different joints, however, it remains unknown if the inflammatory process is similar/distinct in patients with hip vs. knee OA. Read More

    How does the sagittal spinal balance of the scoliotic population deviate from the asymptomatic population?
    BMC Musculoskelet Disord 2018 02 2;19(1):36. Epub 2018 Feb 2.
    Department of Orthopedics, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing, 100191, China.
    Background: Previously, the sagittal spinal balance in both asymptomatic and scoliotic Caucasian people has been characterized and compared. Very recently, the sagittal spino-pelvic parameters among asymptomatic Chinese adults have been studied, and the results were compared with Caucasian adults, indicating that a difference did exist. Unfortunately, the distribution of sagittal standing posture patterns among the Chinese population has not been characterized in either asymptomatic or scoliotic groups. Read More

    Characteristics of cervical sagittal parameters in healthy cervical spine adults and patients with cervical disc degeneration.
    BMC Musculoskelet Disord 2018 02 2;19(1):37. Epub 2018 Feb 2.
    Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
    Background: The cervical sagittal parameters of the normal population and the impact of disc degeneration on cervical sagittal alignment have not been clearly defined yet. This study is applied to investigate the characteristics and relationships of cervical sagittal parameters in normal adults and patients with cervical disc degeneration.

    Methods: We reviewed 50 normal control subjects (normal group, NG) and 50 patients with cervical disc degeneration (degeneration group, DG), who had both cervical MRI and radiographs obtained together, between January 2010 and September 2015. Read More

    Routine versus on demand removal of the syndesmotic screw; a protocol for an international randomised controlled trial (RODEO-trial).
    BMC Musculoskelet Disord 2018 01 31;19(1):35. Epub 2018 Jan 31.
    Department of Surgery, Trauma Unit, Academic Medical Centre, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
    Background: Syndesmotic injuries are common and their incidence is rising. In case of surgical fixation of the syndesmosis a metal syndesmotic screw is used most often. It is however unclear whether this screw needs to be removed routinely after the syndesmosis has healed. Read More

    What do we know about managing Dupuytren's disease cost-effectively?
    BMC Musculoskelet Disord 2018 01 25;19(1):34. Epub 2018 Jan 25.
    Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7FY, UK.
    Background: Dupuytren's disease (DD) is a common and progressive, fibroproliferative disorder of the palmar and digital fascia of the hand. Various treatments have been recommended for advanced disease or to retard progression of early disease and to prevent deterioration of the finger contracture and quality of life. Recent studies have tried to evaluate the clinical and cost-effectiveness of therapies for DD, but there is currently no systematic assessment and appraisal of the economic evaluations. Read More

    Comparison of single-dose radial extracorporeal shock wave and local corticosteroid injection for treatment of carpal tunnel syndrome including mid-term efficacy: a prospective randomized controlled trial.
    BMC Musculoskelet Disord 2018 01 25;19(1):32. Epub 2018 Jan 25.
    Department of Rehabilitation Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Background: Recent studies have reported that radial extracorporeal shock wave therapy (rESWT) reduces pain and improves function in patients with mild to moderately severe carpal tunnel syndrome (CTS) compared to a placebo. However, most of those studies used multi-session rESWT combined with wrist support and evaluation of efficacy was limited to a maximum of 14 weeks.

    Methods: The prospective randomized controlled trial compared efficacy in relieving pain and improving clinical function between single-dose rESWT and local corticosteroid injection (LCsI) over the mid-term (24 weeks). Read More

    Comparison among perfect-C®, zero-P®, and plates with a cage in single-level cervical degenerative disc disease.
    BMC Musculoskelet Disord 2018 01 25;19(1):33. Epub 2018 Jan 25.
    Department of Neurosurgery, National Health Insurance Service Ilsan Hospital, Yonsei University College of Medicine, Goyang, South Korea.
    Background: We intended to analyze the efficacy of a new integrated cage and plate device called Perfect-C for anterior cervical discectomy and fusion (ACDF) to cure single-level cervical degenerative disc disease.

    Methods: We enrolled 148 patients who were subjected to single-level ACDF with one of the following three surgical devices: a Perfect-C implant (41 patients), a Zero-P implant (36 patients), or a titanium plate with a polyetheretherketone (PEEK) cage (71 patients). We conducted a retrospective study to compare the clinical and radiological results among the three groups. Read More

    Correction to: Use of autogenous onlay bone graft for uncontained tibial bone defects in primary total knee arthroplasty.
    BMC Musculoskelet Disord 2018 01 24;19(1):31. Epub 2018 Jan 24.
    Department of Orthopedic Surgery, Veterans Health Service Medical Center, 61 Jinhwangdoro-gil, Gangdong-Gu, Seoul, 134-791, Korea.
    After the publication of this article [1] it came to the attention of the authors that there were 2 errors in the results section: 0.0.856 should be 0. Read More

    Detecting functional change in response to exercise in knee osteoarthritis: a comparison of two computerized adaptive tests.
    BMC Musculoskelet Disord 2018 01 23;19(1):29. Epub 2018 Jan 23.
    MGH Institute of Health Professions, Department of Physical Therapy, 36 1st Avenue, Boston, MA, 02129, USA.
    Background: The intent of this study was to examine and compare the ability to detect change of two patient reported outcome (PRO) instruments that use a computerized adaptive test (CAT) approach to measurement. The Patient Reported Outcomes Measurement Information System (PROMIS®) Physical Function scale is a generic PRO, while the Osteoarthritis Computerized Adaptive Test (OA-CAT) is an osteoarthritis-specific PRO.

    Methods: This descriptive, longitudinal study was conducted in a community setting, involving individuals from the greater Boston area. Read More

    Factors related to subjective satisfaction following microendoscopic foraminotomy for cervical radiculopathy.
    BMC Musculoskelet Disord 2018 01 24;19(1):30. Epub 2018 Jan 24.
    Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 113-8655, Japan.
    Background: Microendoscopic foraminotomy has been reported to be effective for the treatment of cervical radiculopathy, using outcome measurement scores such as the neck disability index (NDI) and numerical rating scale (NRS). However, the scores for spine surgery do not always reflect the true subjective satisfaction of the patient. The purpose of this study was to evaluate factors related to subjective satisfaction following microendoscopic foraminotomy for cervical radiculopathy. Read More

    Manual therapy in the treatment of patients with hemophilia B and inhibitor.
    BMC Musculoskelet Disord 2018 01 22;19(1):26. Epub 2018 Jan 22.
    Department of Hematology, Clínico San Carlos Hospital Madrid, Madrid, Spain.
    Background: The main clinical manifestations of hemophilia are muscle and joint bleeding. Recurrent bleeding leads to a degenerative process known as hemophilic arthropathy. The development of inhibitors (antibodies against FVIII/FIX concentrates) is the main complication in the treatment of hemophilia. Read More

    Radiological changes do not influence clinical mid-term outcome in stemless humeral head replacements with hollow screw fixation: a prospective radiological and clinical evaluation.
    BMC Musculoskelet Disord 2018 01 22;19(1):28. Epub 2018 Jan 22.
    St. Vincent Shoulder and Sports Clinic Vienna, Baumgasse 20A, 1030, Vienna, Austria.
    Background: Stemless shoulder arthroplasty is a fairly new concept. Clinical and radiological follow-up is essential to prove implant safety and concept. This prospective single-centre study was performed to evaluate the influence of radiological changes on clinical mid-term outcome following stemless humeral head replacement with hollow screw fixation. Read More

    Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain.
    BMC Musculoskelet Disord 2018 01 22;19(1):27. Epub 2018 Jan 22.
    Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Campus of Savona. Via Magliotto, 2, 17100, Savona, Italy.
    Placebo and nocebo effects are embodied psycho-neurobiological responses capable of modulating pain and producing changes at different neurobiological, body at perceptual and cognitive levels. These modifications are triggered by different contextual factors (CFs) presented in the therapeutic encounter between patient and healthcare providers, such as healing rituals and signs. The CFs directly impact on the quality of the therapeutic outcome: a positive context, that is a context characterized by the presence of positive CFs, can reduce pain by producing placebo effects, while a negative context, characterized by the presence of negative CFs, can aggravate pain by creating nocebo effects. Read More

    With axial loading during MRI diurnal T2-value changes in lumbar discs are neglectable: a cross sectional study.
    BMC Musculoskelet Disord 2018 01 22;19(1):25. Epub 2018 Jan 22.
    Department of Medical Physics and Techniques, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Background: Axial loading during MRI (alMRI) combined with T2 mapping recently was shown as a promising method to reveal biomechanical intervertebral disc (IVD) characteristics. This feasibility study aims to investigate whether there is a diurnal variation in the IVD T2-value when using alMRI. This is of importance for the planning of when to perform alMRI investigations and for interpretations of alMRI findings in relation to clinical symptoms. Read More

    Disability due to knee pain and somatising tendency in Japanese adults.
    BMC Musculoskelet Disord 2018 01 19;19(1):23. Epub 2018 Jan 19.
    Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Background: Knee pain is common and related to knee osteoarthritis. However, there is a discrepancy between knee pain and radiographic osteoarthritis. In the general population, knee pain is associated with psychological and cognitive factors, which would be one explanation for the discrepancy. Read More

    Bone mineral density at the hip and its relation to fat mass and lean mass in adolescents: the Tromsø Study, Fit Futures.
    BMC Musculoskelet Disord 2018 01 19;19(1):21. Epub 2018 Jan 19.
    Department of Health and Care Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
    Background: Positive association between body weight and bone mass is well established, and the concept of body mass index (BMI) is associated with higher areal bone mineral density (aBMD) and reduced fracture risk. BMI, that comprises both fat mass (FM) and lean mass (LM) may contribute to peak bone mass achievement in different ways. This study explored the influence of body composition in terms of total body LM and FM on hip aBMD-values in adolescence. Read More

    Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis.
    BMC Musculoskelet Disord 2018 01 19;19(1):22. Epub 2018 Jan 19.
    Department of Health Statistics / the Publishing house, Public Health of Shanxi Medical University / Chinese Journal of Rheumatology, Taiyuan, Shanxi, 030001, China.
    Background: The roles of C-reactive protein (CRP) and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (KOA) remain controversial, thus the present study is aimed to explore the relationships between CRP, COMP, and the incidence/progression of KOA.

    Methods: A systematic search was conducted on PubMed and Embase until September, 2016 for all the relevant studies. The pooled mean difference (MD) with its 95% confidence interval (95% CI) based on fixed effects model or random effects model was calculated to assess the potential role of CRP and COMP in the incidence or progression of KOA. Read More

    Concomitant glenohumeral injuries in Neer type II distal clavicle fractures.
    BMC Musculoskelet Disord 2018 01 19;19(1):24. Epub 2018 Jan 19.
    Department General, Trauma and Reconstructive Surgery, Ludwig Maximilians University, Munich University Hospital, Nußbaumstr. 20, 80336, Munich, Germany.
    Background: To identify the prevalence of concomitant glenohumeral injuries in surgically treated Neer type II distal clavicle fractures and relate its clinical importance.

    Methods: Between 11/2011 and 11/2015 41 patients, suffering from a displaced and unstable distal clavicle fracture were included. 20 patients (group 1) received surgical treatment by means of plate osteosynthesis in combination with an arthroscopically assisted coraco-clavicular ligament augmentation. Read More

    Epidemiology of arthritis, chronic back pain, gout, osteoporosis, spondyloarthropathies and rheumatoid arthritis among 1.5 million patients in Australian general practice: NPS MedicineWise MedicineInsight dataset.
    BMC Musculoskelet Disord 2018 01 18;19(1):20. Epub 2018 Jan 18.
    Discipline of General Practice, Adelaide Medical School, NHMRC Centre of Research Excellence to Reduce Inequality in Heart Disease, The University of Adelaide, Adelaide, SA, Australia.
    Background: Previous estimates for the prevalence of musculoskeletal conditions (MSK) and chronic pain in Australia have been based on self-report. We aimed to determine the prevalence and distribution of arthritis, chronic back pain, gout, osteoporosis, spondyloarthropathies and rheumatoid arthritis and current consultations for chronic pain among adults attending Australian general practice, and describe their distribution according to sociodemographic characteristics and presence of co-morbidities.

    Methods: We investigated 1,501,267 active adult patients (57. Read More

    Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis.
    BMC Musculoskelet Disord 2018 01 17;19(1):17. Epub 2018 Jan 17.
    University of Maryland School of Medicine, Baltimore, USA.
    Background: Pain is the principal clinical symptom of osteoarthritis (OA), and development of safe and effective analgesics for OA pain is needed. Drug development of new analgesics for OA pain is impaired by substantial change in pain in patients receiving placebo, and more data describing clinical characteristics and pain categories particularly associated with this phenomenon is needed. The purpose of this post-hoc analysis was to investigate clinical characteristics and pain categories and their association with radiographic progression and placebo pain reduction (PPR) in OA patients as measured the Western Ontario and McMasters Arthritis (WOMAC). Read More

    Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study.
    BMC Musculoskelet Disord 2018 01 17;19(1):16. Epub 2018 Jan 17.
    Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Street, Hefei, China.
    Background: Associations between adipokines and bone mineral density (BMD) in knee osteoarthritis (OA) remain indistinct. The aim of this study was to investigate the cross-sectional associations between serum levels of adipokines and BMD in patients with knee OA.

    Methods: This study included 164 patients with symptomatic knee OA from the Anhui Osteoarthritis study. Read More

    Minimally invasive versus open Transforaminal lumbar Interbody fusion in obese patients: a meta-analysis.
    BMC Musculoskelet Disord 2018 01 17;19(1):15. Epub 2018 Jan 17.
    Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Division of Spine, China International Neurological Institute, Beijing, People's Republic of China.
    Background: Minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) has been employed in increasing cases compared with open TLIF (Open-TLIF). However, it is uncertain whether the advantages of MI-TLIF can also be specifically applied in obese patients. Therefore, the current study was thereby carried out aiming to compare the outcomes of MI-TLIF with those of Open-TLIF in obese patients with lumbar degenerative diseases. Read More

    An unusual case of symptomatic deep vein thrombosis and pulmonary embolism after arthroscopic meniscus surgery.
    BMC Musculoskelet Disord 2018 01 17;19(1):19. Epub 2018 Jan 17.
    Department of Orthopaedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, No.88 Jiefang Road, Hangzhou, 310009, People's Republic of China.
    Background: Although thrombosis complication is rare after arthroscopic meniscus surgery, deep vein thrombosis and pulmonary embolism can be fatal. The associated risk factors and whether anticoagulant prevention after arthroscopic knee surgery is necessary have not reach consensus. Here we present a case of deep vein thrombosis and pulmonary embolism after a common arthroscopic meniscectomy. Read More

    Cementless unicompartmental knee replacement allows early return to normal activity.
    BMC Musculoskelet Disord 2018 01 17;19(1):18. Epub 2018 Jan 17.
    Clinic of Orthopaedic and Trauma Surgery, University of Heidelberg, Schlierbacher Landstr. 200a, 69118, Heidelberg, Germany.
    Background: Physical activity and regular participation in recreational sports gain importance in patients' lifestyle after knee arthroplasty. Cementless unicompartimental Knee replacement with the Oxford System has been introduced into clinical routine. Currently there is no data reporting on the physical activity, return to sports rate and quality of live after medial cementless Oxford Unicompartimental Knee Replacement (OUKR). Read More

    Frailty as a predictor of hospital length of stay after elective total joint replacements in elderly patients.
    BMC Musculoskelet Disord 2018 01 16;19(1):14. Epub 2018 Jan 16.
    Departments of Medicine and Critical Care Medicine and Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM), 900 St-Denis, H2X 0A9, Montréal, Québec, Canada.
    Background: Total joint replacement procedures are increasing in number because of population aging and osteoarthritis development. Defined as a lack of physiological reserves and the inability to adequately respond to external stressors, frailty may be more common than expected in older patients with degenerative arthritis awaiting total joint replacements. The aim of the present study was to assess associations between frailty and adverse outcomes, frailty prevalence among elderly patients awaiting elective TJR, and agreement between 2 frailty screening instruments. Read More

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