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    Characterization of biofilm-forming capacity and resistance to sanitizers of a range of E. coli O26 pathotypes from clinical cases and cattle in Australia.
    BMC Microbiol 2018 May 8;18(1):41. Epub 2018 May 8.
    Present address: CSIRO Agriculture and Food, 39 Kessels Rd, Coopers Plains, Brisbane, QLD, 4108, Australia.
    Background: The formation of biofilms and subsequent encasement of bacterial cells in a complex matrix can enhance resistance to antimicrobials and sterilizing agents making these organisms difficult to eradicate and control. The aim of this study was to evaluate and compare the capacity of 40 E. coli O26 isolates of enterohemorrhagic E. Read More

    Genetic diversity and characterization of arsenic-resistant endophytic bacteria isolated from Pteris vittata, an arsenic hyperaccumulator.
    BMC Microbiol 2018 May 8;18(1):42. Epub 2018 May 8.
    Department of Microbiology, College of Resource Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
    Background: Alleviating arsenic (As) contamination is a high-priority environmental issue. Hyperaccumulator plants may harbor endophytic bacteria able to detoxify As. Therefore, we investigated the distribution, diversity, As (III) resistance levels, and resistance-related functional genes of arsenite-resistant bacterial endophytes in Pteris vittata L. Read More

    Susceptibility patterns and the role of extracellular DNA in Staphylococcus epidermidis biofilm resistance to physico-chemical stress exposure.
    BMC Microbiol 2018 May 2;18(1):40. Epub 2018 May 2.
    Department of Zoology, School of Physical and Biological Sciences, Maseno University, P.O. Box, 333-40105, Maseno, Kenya.
    Background: Over 65% of human infections are ascribed to bacterial biofilms that are often highly resistant to antibiotics and host immunity. Staphylococcus epidermidis is the predominant cause of recurrent nosocomial and biofilm-related infections. However, the susceptibility patterns of S. Read More

    Using NanoSIMS coupled with microfluidics to visualize the early stages of coral infection by Vibrio coralliilyticus.
    BMC Microbiol 2018 Apr 20;18(1):39. Epub 2018 Apr 20.
    Weizmann Institute of Science, Rehovot, Israel.
    Background: Global warming has triggered an increase in the prevalence and severity of coral disease, yet little is known about coral/pathogen interactions in the early stages of infection. The point of entry of the pathogen and the route that they take once inside the polyp is currently unknown, as is the coral's capacity to respond to infection. To address these questions, we developed a novel method that combines stable isotope labelling and microfluidics with transmission electron microscopy (TEM) and nanoscale secondary ion mass spectrometry (NanoSIMS), to monitor the infection process between Pocillopora damicornis and Vibrio coralliilyticus under elevated temperature. Read More

    Carbapenemase-producing Enterobacteriaceae in Mexico: report of seven non-clonal cases in a pediatric hospital.
    BMC Microbiol 2018 Apr 19;18(1):38. Epub 2018 Apr 19.
    Molecular Microbiology Laboratory, Instituto Nacional de Pediatría, Insurgentes Sur 3700-C, Insurgentes Cuicuilco, ZC, 04530, Coyoacán Mexico City, Mexico.
    Background: Carbapenemases-producing Enterobacteriaceae (CPE) are a worldwide public health emergency. In Mexico, reports of CPE are limited, particularly in the pediatric population. Here, we describe the clinical, epidemiological, and molecular characteristics of seven consecutive cases in a third-level pediatric hospital in Mexico City over a four-month period during 2016. Read More

    Molecular characterization and new genotypes of Enterocytozoon bieneusi in pet chipmunks (Eutamias asiaticus) in Sichuan province, China.
    BMC Microbiol 2018 Apr 18;18(1):37. Epub 2018 Apr 18.
    The Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Province, Chengdu, 611130, Sichuan, China.
    Background: Enterocytozoon bieneusi, the most commonly identified microsporidian species in humans, is also identified in livestock, birds, rodents, reptiles, companion animals, even wastewater. However, there is no information available on occurrence of E. bieneusi in pet chipmunks. Read More

    A Recurrent Silent Mutation Implicates fecA in Ethanol Tolerance by Escherichia coli.
    BMC Microbiol 2018 Apr 18;18(1):36. Epub 2018 Apr 18.
    Department of Biological Sciences, Rowan University, 201 Mullica Hill Rd, Glassboro, NJ, 08028, USA.
    Background: An issue associated with efficient bioethanol production is the fact that the desired product is toxic to the biocatalyst. Among other effects, ethanol has previously been found to influence the membrane of E. coli in a dose-dependent manner and induce changes in the lipid composition of the plasma membrane. Read More

    Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers.
    BMC Microbiol 2018 Apr 16;18(1):34. Epub 2018 Apr 16.
    Research group of Host-Microbe Interactions, Department of Medical Biology, Faculty of Health Sciences, UiT-The Arctic University of Norway, 9037, Tromsø, Norway.
    Background: Staphylococcus aureus cell wall anchored Serine Aspartate repeat containing protein D (SdrD) is a member of the microbial surface component recognising adhesive matrix molecules (MSCRAMMs). It is involved in the bacterial adhesion and virulence. However the extent of genetic variation in S. Read More

    Development of the tonsillar microbiome in pigs from newborn through weaning.
    BMC Microbiol 2018 Apr 16;18(1):35. Epub 2018 Apr 16.
    Comparative Medicine and Integrative Biology Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
    Background: Porcine tonsils are lympho-epithelial tissues, colonized by numerous bacteria and viruses, that act as a reservoir for both host-specific pathogens and zoonotic pathogens with a high potential of transmission to humans. There are no existing studies describing the development of the tonsillar microbiome. We sequenced 16S rRNA genes from tonsillar samples of pigs to follow the development of the microbial communities from birth through weaning. Read More

    A Coxiella burnetii phospholipase A homolog pldA is required for optimal growth in macrophages and developmental form lipid remodeling.
    BMC Microbiol 2018 Apr 16;18(1):33. Epub 2018 Apr 16.
    Coxiella Pathogenesis Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
    Background: Many gram-negative bacteria produce an outer membrane phospholipase A (PldA) that plays an important role in outer membrane function and is associated with virulence.

    Results: In the current study, we characterized a pldA mutant of Coxiella burnetii, an intracellular gram-negative pathogen and the agent of human Q fever. The C. Read More

    Non-tuberculous Mycobacterium species causing mycobacteriosis in farmed aquatic animals of South Africa.
    BMC Microbiol 2018 Apr 13;18(1):32. Epub 2018 Apr 13.
    Tuberculosis Laboratory, Agricultural Research Council - Onderstepoort Veterinary Research, Onderstepoort, South Africa.
    Background: Mycobacteriosis caused by non-tuberculous mycobacteria (NTM), is among the most chronic diseases of aquatic animals. In addition, fish mycobacteriosis has substantial economic consequences especially in the aquaculture and fisheries industry as infections may significantly decrease production and trade. Some fish NTM pathogens are highly virulent and zoonotic; as such, infection of aquaria with these pathogens is a public health concern. Read More

    Characterising resuscitation promoting factor fluorescent-fusions in mycobacteria.
    BMC Microbiol 2018 Apr 12;18(1):30. Epub 2018 Apr 12.
    MRC Centre for Molecular Bacteriology and Infection, Department of Medicine, Imperial College London, London, SW7 2AZ, UK.
    Background: Resuscitation promoting factor proteins (Rpfs) are peptidoglycan glycosidases capable of resuscitating dormant mycobacteria, and have been found to play a role in the pathogenesis of tuberculosis. However, the specific roles and localisation of each of the 5 Rpfs in Mycobacterium tuberculosis remain mostly unknown. In this work our aim was to construct fluorescent fusions of M. Read More

    Correction to: Genetic characterization of Bacillus anthracis in Guizhou Province, Southwest of China.
    BMC Microbiol 2018 Apr 12;18(1):31. Epub 2018 Apr 12.
    Institute of communicable disease control and prevention, Guizhou Provincial Centre for Disease Control and Prevention, Guiyang, People's Republic of China.
    Erratum: Upon publication of the original article (1) it was highlighted by the authors that a grant awarded to support the research work of the study was missed in the acknowledgements. It should also be acknowledged that the grant titled "Genotyping and Molecular Epidemiological Characteristic of Bacillus anthracis in Guizhou Province" awarded by the Program of Natural Science Foundation of Guizhou Province (Grant No. Qian Ke He J Word [2015] 2084)also contributed to the resources for this research. Read More

    A nutrient-dependent division antagonist is regulated post-translationally by the Clp proteases in Bacillus subtilis.
    BMC Microbiol 2018 Apr 6;18(1):29. Epub 2018 Apr 6.
    Department of Biology, Washington University, St. Louis, 63130, MO, USA.
    Background: Changes in nutrient availability have dramatic and well-defined impacts on both transcription and translation in bacterial cells. At the same time, the role of post-translational control in adaptation to nutrient-poor environments is poorly understood. Previous studies demonstrate the ability of the glucosyltransferase UgtP to influence cell size in response to nutrient availability. Read More

    Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates.
    BMC Microbiol 2018 Apr 5;18(1):28. Epub 2018 Apr 5.
    Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.
    Background: We and others have previously shown that alterations in the mammalian gut microbiome are associated with diet, notably early life exposure to a maternal high fat diet (HFD). Here, we aimed to further these studies by examining alterations in the gut microbiome of juvenile Japanese macaques (Macaca fuscata) that were exposed to a maternal HFD, weaned onto a control diet, and later supplemented with a synbiotic comprised of psyllium seed and Enterococcus and Lactobacillus species.

    Results: Eighteen month old offspring (n = 7) of 36% HFD fed dams were fed a control (14% fat) diet post weaning, then were synbiotic supplemented for 75 days and longitudinal stool and serum samples were obtained. Read More

    Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1-1 plasmid.
    BMC Microbiol 2018 Apr 3;18(1):27. Epub 2018 Apr 3.
    State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock,School of Life Sciences, Inner Mongolia University, Hohhot, 010070, China.
    Background: The MiniR1-1 plasmid is a derivative of the R1 plasmid, a low copy cloning vector.

    Results: Nucleotide sequencing analysis shows that the MiniR1-1 plasmid is a 6316 bp circular double-stranded DNA molecule with an oriR1 (origin for replication). The plasmid carries the repA, tap, copA and bla genes, and genes for ORF1 and ORF2. Read More

    Detection of CTX-M-15 harboring Escherichia coli isolated from wild birds in Tunisia.
    BMC Microbiol 2018 Apr 2;18(1):26. Epub 2018 Apr 2.
    Laboratoire des Microorganismes et Biomolécules actives, Faculté des Sciences de Tunis, Université de Tunis El Manar, 2092, Tunis, Tunisie.
    Background: The spreading of antibiotic resistant bacteria is becoming nowadays an alarming threat to human and animal health. There is increasing evidence showing that wild birds could significantly contribute to the transmission and spreading of drug-resistant bacteria. However, data for antimicrobial resistance in wild birds remain scarce, especially throughout Africa. Read More

    Gastrointestinal microbial community changes in Atlantic cod (Gadus morhua) exposed to crude oil.
    BMC Microbiol 2018 Apr 2;18(1):25. Epub 2018 Apr 2.
    Department of Mathematics and Natural Sciences, University of Stavanger, N-4036, Stavanger, Norway.
    Background: The expansion of offshore oil exploration increases the risk of marine species being exposed to oil pollution in currently pristine areas. The adverse effects of oil exposure through toxic properties of polycyclic aromatic hydrocarbons (PAHs) have been well studied in Atlantic cod (Gadus morhua). Nevertheless, the fate of conjugated metabolites in the intestinal tract and their effect on the diversity of intestinal microbial community in fish is less understood. Read More

    Foreign peptide triggers boost in pneumococcal metabolism and growth.
    BMC Microbiol 2018 Mar 27;18(1):23. Epub 2018 Mar 27.
    Institute for Infectious Diseases, Faculty of Medicine, University of Bern, Friedbühlstrasse 51, CH-3001, Bern, Switzerland.
    Background: Nonencapsulated Streptococcus pneumoniae bacteria are successful colonizers of the human nasopharynx and often possess genes aliB-like ORF 1 and 2 in place of capsule genes. AliB-like ORF 2 binds peptide FPPQSV, found in Prevotella species, resulting in enhanced colonization. How this response is mediated is so far unknown. Read More

    Screening for inhibitors of mutacin synthesis in Streptococcus mutans using fluorescent reporter strains.
    BMC Microbiol 2018 Mar 27;18(1):24. Epub 2018 Mar 27.
    Helmholtz-Center for Infection Research, Group Microbial Communication, Inhoffenstr. 7, 38124, Braunschweig, Germany.
    Background: Within the polymicrobial dental plaque biofilm, bacteria kill competitors by excreting mixtures of bacteriocins, resulting in improved fitness and survival. Inhibiting their bacteriocin synthesis might therefore be a useful strategy to eliminate specific pathogens. We used Streptococcus mutans, a highly acidogenic inhabitant of dental plaque, as a model and searched for natural products that reduced mutacin synthesis. Read More

    Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.
    BMC Microbiol 2018 Mar 22;18(1):22. Epub 2018 Mar 22.
    Institute of Molecular Biology and Medicine, 3 Togolok Moldo street, 720040, Bishkek, Kyrgyzstan.
    Background: The aim of this study was to identify mutations of rpoB, katG, inhA and ahp-genes associated Mycobacterium tuberculosis resistance to rifampicin (RIF) and isoniazid (INH) in Kyrgyz Republic. We studied 633 smear samples from the primary pulmonary tuberculosis (TB) patients. We verified Mycobacterium tuberculosis susceptibility to RIF and INH using culture method of absolute concentrations, and commercially available test named "TB-BIOCHIP" (Biochip-IMB, Moscow, Russian Federation). Read More

    Nitrate decreases ruminal methane production with slight changes to ruminal methanogen composition of nitrate-adapted steers.
    BMC Microbiol 2018 Mar 20;18(1):21. Epub 2018 Mar 20.
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of China.
    Background: This study was conducted to examine effects of nitrate on ruminal methane production, methanogen abundance, and composition. Six rumen-fistulated Limousin×Jinnan steers were fed diets supplemented with either 0% (0NR), 1% (1NR), or 2% (2NR) nitrate (dry matter basis) regimens in succession. Rumen fluid was taken after two-week adaptation for evaluation of in vitro methane production, methanogen abundance, and composition measurements. Read More

    In silico comparative analysis of GGDEF and EAL domain signaling proteins from the Azospirillum genomes.
    BMC Microbiol 2018 Mar 9;18(1):20. Epub 2018 Mar 9.
    Centro de Investigaciones en Ciencias Microbiológicas, Benemérita Universidad Autónoma de Puebla. Edif. IC11, Ciudad Universitaria, Col. San Manuel Puebla Pue, CP72570, Puebla, Mexico.
    Background: The cyclic-di-GMP (c-di-GMP) second messenger exemplifies a signaling system that regulates many bacterial behaviors of key importance; among them, c-di-GMP controls the transition between motile and sessile life-styles in bacteria. Cellular c-di-GMP levels in bacteria are regulated by the opposite enzymatic activities of diguanylate cyclases and phosphodiesterases, which are proteins that have GGDEF and EAL domains, respectively. Azospirillum is a genus of plant-growth-promoting bacteria, and members of this genus have beneficial effects in many agronomically and ecologically essential plants. Read More

    Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages.
    BMC Microbiol 2018 Mar 1;18(1):19. Epub 2018 Mar 1.
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, 90095, CA, USA.
    Background: A remarkable exception to the large genetic diversity often observed for bacteriophages infecting a specific bacterial host was found for the Cutibacterium acnes (formerly Propionibacterium acnes) phages, which are highly homogeneous. Phages infecting the related species, which is also a member of the Propionibacteriaceae family, Propionibacterium freudenreichii, a bacterium used in production of Swiss-type cheeses, have also been described and are common contaminants of the cheese manufacturing process. However, little is known about their genetic composition and diversity. Read More

    The PhyR homolog RSP_1274 of Rhodobacter sphaeroides is involved in defense of membrane stress and has a moderate effect on RpoE (RSP_1092) activity.
    BMC Microbiol 2018 Feb 27;18(1):18. Epub 2018 Feb 27.
    Institut für Mikrobiologie und Molekularbiologie, Interdiziplinäres Forschungszentrum, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 26-32, 35392, Giessen, Germany.
    Background: A major role of the PhyR-NepR-σ(EcfG) cascade in the general stress response was demonstrated for some bacterial species and considered as conserved in Alphaproteobacteria. The σ(EcfG) factor activates its target genes in response to diverse stresses and NepR represents its anti-sigma factor. PhyR comprises a response regulator domain and a sigma factor domain and acts as anti-sigma factor antagonist. Read More

    Distinct fermentation and antibiotic sensitivity profiles exist in salmonellae of canine and human origin.
    BMC Microbiol 2018 Feb 26;18(1):15. Epub 2018 Feb 26.
    Life and Health Sciences, Aston University, B4 7ET, Birmingham, UK.
    Background: Salmonella enterica is a recognised cause of diarrhoea in dogs and humans, yet the potential for transfer of salmonellosis between dogs and their owners is unclear, with reported evidence both for and against Salmonella as a zoonotic pathogen. A collection of 174 S. enterica isolates from clinical infections in humans and dogs were analysed for serotype distribution, carbon source utilisation, chemical and antimicrobial sensitivity profiles. Read More

    Exploring the arthritogenicity of Streptococcus dysgalactiae subspecies equisimilis.
    BMC Microbiol 2018 Feb 27;18(1):17. Epub 2018 Feb 27.
    Department of Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway.
    Background: During the past decades, Streptococcus dysgalactiae subspecies equisimilis (SDSE) has been increasingly recognized as an important human pathogen. Osteoarticular infections is one of the predominant disease manifestations of SDSE, but the pathogenetic rationale for its arthritogenicity has yet to be unravelled. We aimed to explore if the rising incidence of osteoarticular infections caused by this pathogen in our region emanated from clonal expansion of strains with enhanced tropism for bone and joint tissue components or orthopaedic implants. Read More

    Porphyromonas gingivalis ATCC 33277 promotes intercellular adhesion molecule-1 expression in endothelial cells and monocyte-endothelial cell adhesion through macrophage migration inhibitory factor.
    BMC Microbiol 2018 Feb 26;18(1):16. Epub 2018 Feb 26.
    Department of Periodontics and Oral Biology, School of Stomatology, China Medical University, Nanjing North St.117, Shenyang, Liaoning, 110002, China.
    Background: Porphyromonas gingivalis (P. gingivalis), one of the main pathogenic bacteria involved in periodontitis, induces the expression of intercellular adhesion molecule - 1 (ICAM-1) and monocyte-endothelial cell adhesion. This effect plays a pivotal role in atherosclerosis development. Read More

    Identification of novel genes in the carotenogenic and oleaginous yeast Rhodotorula toruloides through genome-wide insertional mutagenesis.
    BMC Microbiol 2018 Feb 21;18(1):14. Epub 2018 Feb 21.
    Biomaterials and Biocatalysts Group, Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore, 117604, Singapore.
    Background: Rhodotorula toruloides is an outstanding producer of lipids and carotenoids. Currently, information on the key metabolic pathways and their molecular basis of regulation remains scarce, severely limiting efforts to engineer it as an industrial host.

    Results: We have adapted Agrobacterium tumefaciens-mediated transformation (ATMT) as a gene-tagging tool for the identification of novel genes in R. Read More

    A microbiome case-control study of recurrent acute otitis media identified potentially protective bacterial genera.
    BMC Microbiol 2018 Feb 20;18(1):13. Epub 2018 Feb 20.
    The Marshall Centre for Infectious Diseases Research and Training, School of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia.
    Background: Recurrent acute otitis media (rAOM, recurrent ear infection) is a common childhood disease caused by bacteria termed otopathogens, for which current treatments have limited effectiveness. Generic probiotic therapies have shown promise, but seem to lack specificity. We hypothesised that healthy children with no history of AOM carry protective commensal bacteria that could be translated into a specific probiotic therapy to break the cycle of re-infection. Read More

    Transcriptome analysis of different growth stages of Aspergillus oryzae reveals dynamic changes of distinct classes of genes during growth.
    BMC Microbiol 2018 02 14;18(1):12. Epub 2018 Feb 14.
    Jiangxi Key Laboratory of Bioprocess Engineering and Co-Innovation Center for In-vitro Diagnostic Reagents and Devices of Jiangxi Province, College of Life Sciences, Jiangxi Science & Technology Normal University, Nanchang, 330013, China.
    Background: The gene expression profile and metabolic pathways of Aspergillus oryzae underlying the anatomical and morphological differentiation across different growth stages have not been fully characterized. The rapid development of next-generation sequencing technologies provides advanced knowledge of the genomic organization of A. oryzae. Read More

    Microtiter miniature shaken bioreactor system as a scale-down model for process development of production of therapeutic alpha-interferon2b by recombinant Escherichia coli.
    BMC Microbiol 2018 01 4;18(1). Epub 2018 Jan 4.
    Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.
    Background: Demand for high-throughput bioprocessing has dramatically increased especially in the biopharmaceutical industry because the technologies are of vital importance to process optimization and media development. This can be efficiently boosted by using microtiter plate (MTP) cultivation setup embedded into an automated liquid-handling system. The objective of this study was to establish an automated microscale method for upstream and downstream bioprocessing of α-IFN2b production by recombinant Escherichia coli. Read More

    Metagenomic analysis of microbial community and function involved in cd-contaminated soil.
    BMC Microbiol 2018 02 13;18(1):11. Epub 2018 Feb 13.
    Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of life sciences, Sichuan University, No. 24 South Section 1, Yihuan Road, Chengdu, 610065, China.
    Background: Soil contaminated with the heavy metal Cadmium (Cd) is a widespread problem in many parts of the world. Based on metagenomic analysis, we investigated the functional potential and structural diversity of the microbial community in Cd-contaminated and non-contaminated soil samples and we explored the associated metabolic pathway network in cluster of orthologous groups (COG) and Kyoto Encyclopedia of Genes and Genomes (KEGG).

    Results: The results showed that microorganisms in these soils were quite abundant, and many of them possessed numerous physiological functions. Read More

    Comparative assessment of the quality of commercial black and green tea using microbiology analyses.
    BMC Microbiol 2018 01 5;18(1). Epub 2018 Jan 5.
    Department of Biology, University of Naples Federico II, Via Cinthia, 80126, Naples, Italy.
    Background: Drinking tea constitutes a tradition which is deeply rooted in the culture of several countries. Moreover, in recent years, tea consumption is growing all over the world. Improper herbal tea storage (long periods, humid environments) represents a relevant health hazard for consumers because of the growth of bacteria and molds. Read More

    Molecular epidemiological investigations of plague in Eastern Province of Zambia.
    BMC Microbiol 2018 01 4;18(1). Epub 2018 Jan 4.
    Pest Management Centre, Sokoine University of Agriculture, Morogoro, Tanzania.
    Background: Plague is a flea-borne zoonotic and invasive disease caused by a gram negative coccobacillus bacterium called Yersinia pestis. Plague has caused three devastating pandemics globally namely: the Justinian, Black Death and Oriental plague. The disease in the Eastern Province of Zambia has been reported in Nyimba and Sinda Districts in the past 15 years. Read More

    Whole genome analysis of hypervirulent Klebsiella pneumoniae isolates from community and hospital acquired bloodstream infection.
    BMC Microbiol 2018 01 8;18(1). Epub 2018 Jan 8.
    Department of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.
    Background: Hypervirulent K. pneumoniae (hvKp) causes severe community acquired infections, predominantly in Asia. Though initially isolated from liver abscesses, they are now prevalent among invasive infections such as bacteraemia. Read More

    Legionella effector AnkX interacts with host nuclear protein PLEKHN1.
    BMC Microbiol 2018 01 5;18(1). Epub 2018 Jan 5.
    Department of Biological Sciences, University of Delaware, 105 The Green, Newark, DE, 19716, USA.
    Background: The intracellular bacterial pathogen Legionella pneumophila proliferates in human alveolar macrophages, resulting in a severe pneumonia termed Legionnaires' disease. Throughout the course of infection, L. pneumophila remains enclosed in a specialized membrane compartment that evades fusion with lysosomes. Read More

    Growth and metabolic characteristics of oleaginous microalgal isolates from Nilgiri biosphere Reserve of India.
    BMC Microbiol 2018 01 3;18(1). Epub 2018 Jan 3.
    Department of Agricultural Microbiology, Tamil Nadu Agricultural University, Coimbatore, 641003, Tamil Nadu, India.
    Background: Renewable energy for sustainable development is a subject of a worldwide debate since continuous utilization of non-renewable energy sources has a drastic impact on the environment and economy; a search for alternative energy resources is indispensable. Microalgae are promising and potential alternate energy resources for biodiesel production. Thus, our efforts were focused on surveying the natural diversity of microalgae for the production of biodiesel. Read More

    Detection and genotyping of Helicobacter pylori in saliva versus stool samples from asymptomatic individuals in Northeastern Thailand reveals intra-host tissue-specific H. pylori subtypes.
    BMC Microbiol 2018 01 30;18(1):10. Epub 2018 Jan 30.
    Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
    Background: Two-thirds of the world's population is thought to be infected by Helicobacter pylori. Although most people infected with H. pylori are asymptomatic, this pathogen is associated with several gastric pathologies including cancer. Read More

    PHENOS: a high-throughput and flexible tool for microorganism growth phenotyping on solid media.
    BMC Microbiol 2018 01 24;18(1). Epub 2018 Jan 24.
    Department of Genetics & Genome Biology, University of Leicester, Leicester, LE1 7RH, UK.
    Background: Microbial arrays, with a large number of different strains on a single plate printed with robotic precision, underpin an increasing number of genetic and genomic approaches. These include Synthetic Genetic Array analysis, high-throughput Quantitative Trait Loci (QTL) analysis and 2-hybrid techniques. Measuring the growth of individual colonies within these arrays is an essential part of many of these techniques but is useful for any work with arrays. Read More

    Genetic polymorphisms identify in species/biovars of Brucella isolated in China between 1953 and 2013 by MLST.
    BMC Microbiol 2018 01 10;18(1). Epub 2018 Jan 10.
    State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
    Background: Brucellosis incidence in China is divided into three stages: high incidence (1950s-1960s), decline (1970s-1980s), and re-emergence (1990s-2010s). At the re-emergence stage, Brucellosis incidence grew exponentially and spread to all 32 provinces. We describe the magnitude and the etiological distribution changes in mainland China by genotyping data and emphasize its recent reemergence. Read More

    Phosphate signaling through alternate conformations of the PstSCAB phosphate transporter.
    BMC Microbiol 2018 01 19;18(1). Epub 2018 Jan 19.
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, USA.
    Background: Phosphate is an essential compound for life. Escherichia coli employs a signal transduction pathway that controls the expression of genes that are required for the high-affinity acquisition of phosphate and the utilization of alternate sources of phosphorous. These genes are only expressed when environmental phosphate is limiting. Read More

    Isolation and characterization of HepP: a virulence-related Pseudomonas aeruginosa heparinase.
    BMC Microbiol 2017 Dec 16;17(1):233. Epub 2017 Dec 16.
    Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, 3601 4th St. Mail Stop 6591, Lubbock, TX, 79430, USA.
    Background: Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections in immunocompromised hosts including severely burned patients. In burn patients, P. aeruginosa infection often leads to septic shock and death. Read More

    The distinctive cell division interactome of Neisseria gonorrhoeae.
    BMC Microbiol 2017 Dec 12;17(1):232. Epub 2017 Dec 12.
    Department of Microbiology and Immunology, College of Medicine, Saskatoon, SK, S7N 5E5, Canada.
    Background: Bacterial cell division is an essential process driven by the formation of a Z-ring structure, as a cytoskeletal scaffold at the mid-cell, followed by the recruitment of various proteins which form the divisome. The cell division interactome reflects the complement of different interactions between all divisome proteins. To date, only two cell division interactomes have been characterized, in Escherichia coli and in Streptococcus pneumoniae. Read More

    The relation between Blastocystis and the intestinal microbiota in Swedish travellers.
    BMC Microbiol 2017 Dec 11;17(1):231. Epub 2017 Dec 11.
    Department of Clinical Microbiology, Umeå University, -901 87, Umeå, SE, Sweden.
    Background: Blastocystis sp. is a unicellular eukaryote that is commonly found in the human intestine. Its ability to cause disease is debated and a subject for ongoing research. Read More

    6S RNA plays a role in recovery from nitrogen depletion in Synechocystis sp. PCC 6803.
    BMC Microbiol 2017 Dec 8;17(1):229. Epub 2017 Dec 8.
    Institute for Synthetic Microbiology, Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich Heine University Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany.
    Background: The 6S RNA is a global transcriptional riboregulator, which is exceptionally widespread among most bacterial phyla. While its role is well-characterized in some heterotrophic bacteria, we subjected a cyanobacterial homolog to functional analysis, thereby extending the scope of 6S RNA action to the special challenges of photoautotrophic lifestyles.

    Results: Physiological characterization of a 6S RNA deletion strain (ΔssaA) demonstrates a delay in the recovery from nitrogen starvation. Read More

    Use of a mixed culture strategy to isolate halophilic bacteria with antibacterial and cytotoxic activity from the Manaure solar saltern in Colombia.
    BMC Microbiol 2017 Dec 8;17(1):230. Epub 2017 Dec 8.
    Bioscience Doctoral Program, Grupo de Investigación en Bioprospección, Faculty of Engineering, Universidad de La Sabana, Campus Puente del Común, Km 7, Autopista Norte de Bogotá, Chía, Colombia.
    Background: Water evaporation in solar salterns creates salinity gradients that promote the adaptation of microbial species to different salinities. This competitive habitat challenges the metabolic capabilities of microorganisms and promotes alterations in their production of secondary metabolites. Thus, solar salterns are a potentially important source of new natural products. Read More

    Investigation on the differentiation of two Ustilago esculenta strains - implications of a relationship with the host phenotypes appearing in the fields.
    BMC Microbiol 2017 Dec 6;17(1):228. Epub 2017 Dec 6.
    Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang, 310018, China.
    Background: Ustilago esculenta, a pathogenic basidiomycete fungus, infects Zizania latifolia to form edible galls named Jiaobai in China. The distinct growth conditions of U. esculenta induced Z. Read More

    Characterization of lpaH2 gene corresponding to lipopeptide synthesis in Bacillus amyloliquefaciens HAB-2.
    BMC Microbiol 2017 Dec 4;17(1):227. Epub 2017 Dec 4.
    Institute of Tropical Agriculture and Foresty, Hainan University, Hainan, China.
    Background: Bacillus spp. have prominent ability to suppress plant pathogens and corresponding diseases. Previous analyses of Bacillus spp. Read More

    Comparison of lipopolysaccharides composition of two different strains of Helicobacter pylori.
    BMC Microbiol 2017 Dec 4;17(1):226. Epub 2017 Dec 4.
    Division of Infectious Diseases, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, San Diego, California, 92093, USA.
    Background: Helicobacter pylori (H. pylori) is a Gram-negative, microaerophilic bacterium that is recognized as a major cause of chronic gastritis, peptic ulcers, and gastric cancer. Comparable to other Gram-negative bacteria, lipopolysaccharides (LPS) are an important cellular component of the outer membrane of H. Read More

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