1,892 results match your criteria BMC Medical Research Methodology [Journal]


Development of an interactive web-based tool to conduct and interrogate meta-analysis of diagnostic test accuracy studies: MetaDTA.

BMC Med Res Methodol 2019 Apr 18;19(1):81. Epub 2019 Apr 18.

NIHR Complex Reviews Support Unit, University of Leicester & University of Glasgow, Glasgow, UK.

Background: Recommended statistical methods for meta-analysis of diagnostic test accuracy studies require relatively complex bivariate statistical models which can be a barrier for non-statisticians. A further barrier exists in the software options available for fitting such models. Software accessible to non-statisticians, such as RevMan, does not support the fitting of bivariate models thus users must seek statistical support to use R, Stata or SAS. Read More

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https://bmcmedresmethodol.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12874-019-0724-xDOI Listing
April 2019
1 Read

Towards greater understanding of implementation during systematic reviews of complex healthcare interventions: the framework for implementation transferability applicability reporting (FITAR).

BMC Med Res Methodol 2019 Apr 18;19(1):80. Epub 2019 Apr 18.

School of Health and Related Research, University of Sheffield, Regent Court, Regent Street, Sheffield, S14DA, UK.

Background: There have been calls for greater consideration of applicability and transferability in systematic reviews, to improve their usefulness in informing policy and practice. Understanding how evidence is, or is not applicable and transferable to varying local situations and contexts, is a key challenge for systematic review synthesis in healthcare. Assessing applicability and transferability in systematic reviews is reported to be difficult, particularly in reviews of complex interventions. Read More

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http://dx.doi.org/10.1186/s12874-019-0723-yDOI Listing

CPMCGLM: an R package for p-value adjustment when looking for an optimal transformation of a single explanatory variable in generalized linear models.

BMC Med Res Methodol 2019 Apr 16;19(1):79. Epub 2019 Apr 16.

MINT UMR INSERM 1066, CNRS 6021, Université d'Angers, UFR Santé, 16 Boulevard Davier, Angers Cedex, 49085, France.

Background: In medical research, explanatory continuous variables are frequently transformed or converted into categorical variables. If the coding is unknown, many tests can be used to identify the "optimal" transformation. This common process, involving the problems of multiple testing, requires a correction of the significance level. Read More

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http://dx.doi.org/10.1186/s12874-019-0711-2DOI Listing

Protocol registration or development may benefit the design, conduct and reporting of dose-response meta-analysis: empirical evidence from a literature survey.

BMC Med Res Methodol 2019 Apr 11;19(1):78. Epub 2019 Apr 11.

Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China.

Background: To investigate the prevalence of protocol registration (or development) among published dose-response meta-analyses (DRMAs), and whether DRMAs with a protocol are better than those not.

Methods: Three databases were searched for eligible DRMAs. The modified AMSTAR (14 items) and PRISMA checklists (26 items) were used to assess the methodological and reporting quality, with each item assigned 1 point if it met the requirement or 0 if not. Read More

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http://dx.doi.org/10.1186/s12874-019-0715-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460643PMC
April 2019
2.270 Impact Factor

The judgement of biases included in the category "other bias" in Cochrane systematic reviews of interventions: a systematic survey.

BMC Med Res Methodol 2019 Apr 11;19(1):77. Epub 2019 Apr 11.

Catholic University of Croatia, Zagreb, Croatia.

Background: Clinical decisions are made based on Cochrane reviews, but the implementation of results of evidence syntheses such as Cochrane reviews is problematic if the evidence is not prepared consistently. All systematic reviews should assess the risk of bias (RoB) in included studies, and in Cochrane reviews, this is done by using Cochrane RoB tool. However, the tool is not necessarily applied according to the instructions. Read More

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http://dx.doi.org/10.1186/s12874-019-0718-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458756PMC
April 2019
2 Reads

Languages for different health information readers: multitrait-multimethod content analysis of Cochrane systematic reviews textual summary formats.

BMC Med Res Methodol 2019 Apr 5;19(1):75. Epub 2019 Apr 5.

Cochrane Croatia and Department of Research in Biomedicine and Health, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia.

Background: Although subjective expressions and linguistic fluency have been shown as important factors in processing and interpreting textual facts, analyses of these traits in textual health information for different audiences are lacking. We analyzed the readability and linguistic psychological and emotional characteristics of different textual summary formats of Cochrane systematic reviews.

Methods: We performed a multitrait-multimethod cross-sectional study of Press releases available at Cochrane web site (n = 162) and corresponding Scientific abstracts (n = 158), Cochrane Clinical Answers (n = 35) and Plain language summaries in English (n = 156), French (n = 101), German (n = 41) and Croatian (n = 156). Read More

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http://dx.doi.org/10.1186/s12874-019-0716-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451281PMC

Assessments of attrition bias in Cochrane systematic reviews are highly inconsistent and thus hindering trial comparability.

BMC Med Res Methodol 2019 Apr 5;19(1):76. Epub 2019 Apr 5.

Center for Evidence-Based Medicine and Health Care, Catholic University of Croatia, Ilica 242, 10000, Zagreb, Croatia.

Background: An important part of the systematic review methodology is appraisal of the risk of bias in included studies. Cochrane systematic reviews are considered golden standard regarding systematic review methodology, but Cochrane's instructions for assessing risk of attrition bias are vague, which may lead to inconsistencies in authors' assessments. The aim of this study was to analyze consistency of judgments and support for judgments of attrition bias in Cochrane reviews of interventions published in the Cochrane Database of Systematic Reviews (CDSR). Read More

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http://dx.doi.org/10.1186/s12874-019-0717-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451283PMC
April 2019
4 Reads

Two-stage optimal designs with survival endpoint when the follow-up time is restricted.

BMC Med Res Methodol 2019 Apr 3;19(1):74. Epub 2019 Apr 3.

School of Computer and Information Engineering, Zhejiang Gongshang University, Hangzhou, Zhejiang, China.

Background: Survival endpoint is frequently used in early phase clinical trials as the primary endpoint to assess the activity of a new treatment. Existing two-stage optimal designs with survival endpoint either over estimate the sample size or compute power outside the alternative hypothesis space.

Methods: We propose a new single-arm two-stage optimal design with survival endpoint by using the one-sample log rank test based on exact variance estimates. Read More

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http://dx.doi.org/10.1186/s12874-019-0696-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448233PMC
April 2019
1 Read

The impact of survey mode on the response rate in a survey of the factors that influence Minnesota physicians' disclosure practices.

BMC Med Res Methodol 2019 Apr 2;19(1):73. Epub 2019 Apr 2.

Division of Health Policy and Management, University of Minnesota, 420 Delaware Street Southeast, MMC 729, Minneapolis, MN, 55455, USA.

Background: There is evidence that the physician response rate is declining. In response to this, methods for increasing the physician response rate are currently being explored. This paper examines the response rate and extent of non-response bias in a mixed-mode study of Minnesota physicians. Read More

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http://dx.doi.org/10.1186/s12874-019-0719-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444519PMC
April 2019
3 Reads

Comparison and validation of accelerometer wear time and non-wear time algorithms for assessing physical activity levels in children and adolescents.

BMC Med Res Methodol 2019 Apr 2;19(1):72. Epub 2019 Apr 2.

University of Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, CIC 1403 - Centre d'investigation clinique, Avenue Eugène Avinée, 59037 Lille Cedex, F-59000, Lille, France.

Background: Accelerometers are widely used to measure sedentary time and daily physical activity (PA). However, data collection and processing criteria, such as non-wear time rules might affect the assessment of total PA and sedentary time and the associations with health variables. The study aimed to investigate whether the choice of different non-wear time definitions would affect the outcomes of PA levels in youth. Read More

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http://dx.doi.org/10.1186/s12874-019-0712-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444637PMC

Two-stage estimation to adjust for treatment switching in randomised trials: a simulation study investigating the use of inverse probability weighting instead of re-censoring.

BMC Med Res Methodol 2019 Mar 29;19(1):69. Epub 2019 Mar 29.

UMIT - University for Health Sciences, Medical Informatics and Technology, Eduard-Wallnöfer-Zentrum 1, 6060, Hall in Tirol, Austria.

Background: Treatment switching is common in randomised trials of oncology treatments, with control group patients switching onto the experimental treatment during follow-up. This distorts an intention-to-treat comparison of the treatments under investigation. Two-stage estimation (TSE) can be used to estimate counterfactual survival times for patients who switch treatments - that is, survival times that would have been observed in the absence of switching. Read More

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http://dx.doi.org/10.1186/s12874-019-0709-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444622PMC
March 2019
1 Read

Understanding the importance of key risk factors in predicting chronic bronchitic symptoms using a machine learning approach.

BMC Med Res Methodol 2019 Mar 29;19(1):70. Epub 2019 Mar 29.

Department of Preventive Medicine, University of Southern California, 2001 N. Soto Street, MC-9234, Los Angeles, CA, 90089, USA.

Background: Chronic respiratory symptoms involving bronchitis, cough and phlegm in children are underappreciated but pose a significant public health burden. Efforts for prevention and management could be supported by an understanding of the relative importance of determinants, including environmental exposures. Thus, we aim to develop a prediction model for bronchitic symptoms. Read More

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http://dx.doi.org/10.1186/s12874-019-0708-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441159PMC
March 2019
3 Reads

Bayes factors for superiority, non-inferiority, and equivalence designs.

BMC Med Res Methodol 2019 Mar 29;19(1):71. Epub 2019 Mar 29.

Departments of Medicine, of Health Research and Policy, of Biomedical Data Science, and of Statistics, and Meta-Research Innovation Center, Stanford, USA.

Background: In clinical trials, study designs may focus on assessment of superiority, equivalence, or non-inferiority, of a new medicine or treatment as compared to a control. Typically, evidence in each of these paradigms is quantified with a variant of the null hypothesis significance test. A null hypothesis is assumed (null effect, inferior by a specific amount, inferior by a specific amount and superior by a specific amount, for superiority, non-inferiority, and equivalence respectively), after which the probabilities of obtaining data more extreme than those observed under these null hypotheses are quantified by p-values. Read More

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http://dx.doi.org/10.1186/s12874-019-0699-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441196PMC
March 2019
1 Read

Crowding in the emergency department in the absence of boarding - a transition regression model to predict departures and waiting time.

BMC Med Res Methodol 2019 Mar 29;19(1):68. Epub 2019 Mar 29.

Department of Public Health, Aarhus University, Aarhus, Denmark.

Background: Crowding in the emergency department (ED) is associated with increased mortality, increased treatment cost, and reduced quality of care. Crowding arises when demand exceed resources in the ED and a first sign may be increasing waiting time. We aimed to quantify predictors for departure from the ED, and relate this to waiting time in the ED before departure. Read More

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http://dx.doi.org/10.1186/s12874-019-0710-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440135PMC

Strategies for eliciting and synthesizing evidence for guidelines in rare diseases.

BMC Med Res Methodol 2019 Mar 28;19(1):67. Epub 2019 Mar 28.

McMaster University, Hamilton, Canada.

Background: Rare diseases are a global public health priority. Though each disease is rare, when taken together the thousands of known rare diseases cause significant morbidity and mortality, impact quality of life, and confer a social and economic burden on families and communities. These conditions are, by their nature, encountered very infrequently by individual clinicians, who may feel unprepared to address their diagnosis and treatment. Read More

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https://bmcmedresmethodol.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12874-019-0713-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437842PMC
March 2019
4 Reads

Attempting rigour and replicability in thematic analysis of qualitative research data; a case study of codebook development.

BMC Med Res Methodol 2019 Mar 28;19(1):66. Epub 2019 Mar 28.

Bioethics Centre, University of Otago, Dunedin, New Zealand.

Background: Navigating the world of qualitative thematic analysis can be challenging. This is compounded by the fact that detailed descriptions of methods are often omitted from qualitative discussions. While qualitative research methodologies are now mature, there often remains a lack of fine detail in their description both at submitted peer reviewed article level and in textbooks. Read More

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http://dx.doi.org/10.1186/s12874-019-0707-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437927PMC

Methods to increase response rates to a population-based maternity survey: a comparison of two pilot studies.

BMC Med Res Methodol 2019 Mar 20;19(1):65. Epub 2019 Mar 20.

Policy Research Unit in Maternal Health and Care, National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK.

Background: Surveys are established methods for collecting population data that are unavailable from other sources; however, response rates to surveys are declining. A number of methods have been identified to increase survey returns yet response rates remain low. This paper evaluates the impact of five selected methods on the response rate to pilot surveys, conducted prior to a large-scale National Maternity Survey in England. Read More

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http://dx.doi.org/10.1186/s12874-019-0702-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425628PMC

Machine learning in medicine: a practical introduction.

BMC Med Res Methodol 2019 Mar 19;19(1):64. Epub 2019 Mar 19.

Department of Surgery, Harvard Medical School, 25 Shattuck Street, Boston, 01225, Massachusetts, USA.

Background: Following visible successes on a wide range of predictive tasks, machine learning techniques are attracting substantial interest from medical researchers and clinicians. We address the need for capacity development in this area by providing a conceptual introduction to machine learning alongside a practical guide to developing and evaluating predictive algorithms using freely-available open source software and public domain data.

Methods: We demonstrate the use of machine learning techniques by developing three predictive models for cancer diagnosis using descriptions of nuclei sampled from breast masses. Read More

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http://dx.doi.org/10.1186/s12874-019-0681-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425557PMC
March 2019
2 Reads

Adaptation and psychometric properties of the Norwegian version of the heart continuity of care questionnaire (HCCQ).

BMC Med Res Methodol 2019 Mar 18;19(1):62. Epub 2019 Mar 18.

Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Førde, Norway.

Background: Continuity of cardiac care after hospital discharge is a priority, especially as healthcare systems become increasingly complex and fragmented. There are few available instruments to measure continuity of cardiac care, especially from the patient perspective. The aim of this study was (1) to translate and adapt the Heart Continuity of Care Questionnaire (HCCQ) to conditions in Norway, and (2) to determine its psychometric properties in self-report format administered to patients after percutaneous coronary intervention (PCI). Read More

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http://dx.doi.org/10.1186/s12874-019-0706-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423885PMC

Assessing the maturity of the healthcare system for integrated care: testing measurement properties of the SCIROCCO tool.

BMC Med Res Methodol 2019 Mar 18;19(1):63. Epub 2019 Mar 18.

Department of Family Medicine and Chronic Care, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, P.O. 103, B-1090, Brussels, Belgium.

Background: The Scaling Integrated Care in Context (SCIROCCO) tool has been developed to facilitate knowledge transfer and learning about the implementation and scaling-up of integrated care in European regions. To adequately test the functionality of the tool in assessing the maturity for integrated care within regions, this study evaluated its structural validity, internal consistency and convergent validity.

Methods: Exploratory factor analysis was used to investigate the structural validity of the 12-items of the SCIROCCO tool. Read More

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http://dx.doi.org/10.1186/s12874-019-0704-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423766PMC

Two new approaches for the visualisation of models for network meta-analysis.

BMC Med Res Methodol 2019 Mar 18;19(1):61. Epub 2019 Mar 18.

Statistical Innovation Group, Advanced Analytics Centre, AstraZeneca Cambridge, Cambridge, UK.

Background: Meta-analysis is a useful tool for combining evidence from multiple studies to estimate a pooled treatment effect. An extension of meta-analysis, network meta-analysis, is becoming more commonly used as a way to simultaneously compare multiple treatments in a single analysis. Despite the variety of approaches available for presenting fitted models, ascertaining an intuitive understanding of these models is often difficult. Read More

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http://dx.doi.org/10.1186/s12874-019-0689-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423884PMC

Implementation fidelity in a complex intervention promoting psychosocial well-being following stroke: an explanatory sequential mixed methods study.

BMC Med Res Methodol 2019 Mar 15;19(1):59. Epub 2019 Mar 15.

Institute of Health and Society and Research Center for Habilitation and Rehabilitation Services and Models (CHARM), University of Oslo, P.O. Box 1130 Blindern, 0318, Oslo, Norway.

Background: Evaluation of complex interventions should include a process evaluation to give evaluators, researchers, and policy makers greater confidence in the outcomes reported from RCTs. Implementation fidelity can be part of a process evaluation and refers to the degree to which an intervention is delivered according to protocol. The aim of this implementation fidelity study was to evaluate to what extent a dialogue-based psychosocial intervention was delivered according to protocol. Read More

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http://dx.doi.org/10.1186/s12874-019-0694-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419826PMC
March 2019
2 Reads

The influence of interviewers on survey responses among female sex workers in Zambia.

BMC Med Res Methodol 2019 Mar 15;19(1):60. Epub 2019 Mar 15.

Francis I. Proctor Foundation, University of California, San Francisco, CA, USA.

Background: Interviewers can substantially affect self-reported data. This may be due to random variation in interviewers' ability to put respondents at ease or in how they frame questions. It may also be due to systematic differences such as social distance between interviewer and respondent (e. Read More

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http://dx.doi.org/10.1186/s12874-019-0703-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419821PMC

A Bayesian hierarchical logistic regression model of multiple informant family health histories.

BMC Med Res Methodol 2019 Mar 12;19(1):56. Epub 2019 Mar 12.

National Institutes of Health, Bethesda, MD, USA.

Background: Family health history (FHH) inherently involves collecting proxy reports of health statuses of related family members. Traditionally, such information has been collected from a single informant. More recently, research has suggested that a multiple informant approach to collecting FHH results in improved individual risk assessments. Read More

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http://dx.doi.org/10.1186/s12874-019-0700-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419428PMC
March 2019
1 Read

Bias in pharmacoepidemiologic studies using secondary health care databases: a scoping review.

BMC Med Res Methodol 2019 Mar 11;19(1):53. Epub 2019 Mar 11.

Department of Preventive Medicine and Public Health, University of Santiago de Compostela, c/ San Francisco s/n, 15786, Santiago de Compostela, A Coruña, Spain.

Background: The availability of clinical and therapeutic data drawn from medical records and administrative databases has entailed new opportunities for clinical and epidemiologic research. However, these databases present inherent limitations which may render them prone to new biases. We aimed to conduct a structured review of biases specific to observational clinical studies based on secondary databases, and to propose strategies for the mitigation of those biases. Read More

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http://dx.doi.org/10.1186/s12874-019-0695-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419460PMC
March 2019
2 Reads

Correction to: Parametric assumptions equate to hidden observations: comparing the efficiency of nonparametric and parametric models for estimating time to AIDS or death in a cohort of HIV-positive women.

BMC Med Res Methodol 2019 Mar 15;19(1):58. Epub 2019 Mar 15.

Department of Epidemiology, University of North Carolina at Chapel Hill, 135 Dauer Drive, 2101 McGavran-Greenberg Hall, CB #7435, Chapel Hill, NC, 27599, USA.

. Read More

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http://dx.doi.org/10.1186/s12874-019-0691-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419485PMC

Advancing complexity science in healthcare research: the logic of logic models.

BMC Med Res Methodol 2019 Mar 12;19(1):55. Epub 2019 Mar 12.

Bradford Institute for Health Research, Temple Bank House, Bradford Royal Infirmary, Duckworth Lane, Bradford, BD9 6RJ, UK.

Background: Logic models are commonly used in evaluations to represent the causal processes through which interventions produce outcomes, yet significant debate is currently taking place over whether they can describe complex interventions which adapt to context. This paper assesses the logic models used in healthcare research from a complexity perspective. A typology of existing logic models is proposed, as well as a formal methodology for deriving more flexible and dynamic logic models. Read More

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http://dx.doi.org/10.1186/s12874-019-0701-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419426PMC

A descriptive analysis of the characteristics and the peer review process of systematic review protocols published in an open peer review journal from 2012 to 2017.

BMC Med Res Methodol 2019 Mar 13;19(1):57. Epub 2019 Mar 13.

Institute for Research in Operative Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany.

Background: An a priori design is essential to reduce the risk of bias in systematic reviews (SRs). To this end, authors can register their SR with PROSPERO, and/or publish a SR protocol in an academic journal. The latter has the advantage that the manuscript for the SR protocol is usually peer-reviewed. Read More

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http://dx.doi.org/10.1186/s12874-019-0698-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415341PMC

Sample size calculations for model validation in linear regression analysis.

BMC Med Res Methodol 2019 Mar 12;19(1):54. Epub 2019 Mar 12.

Department of Management Science, National Chiao Tung University, Hsinchu, Taiwan, 30010, Republic of China.

Background: Linear regression analysis is a widely used statistical technique in practical applications. For planning and appraising validation studies of simple linear regression, an approximate sample size formula has been proposed for the joint test of intercept and slope coefficients.

Methods: The purpose of this article is to reveal the potential drawback of the existing approximation and to provide an alternative and exact solution of power and sample size calculations for model validation in linear regression analysis. Read More

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http://dx.doi.org/10.1186/s12874-019-0697-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416874PMC

Validation of the global activity limitation indicator in Taiwan.

BMC Med Res Methodol 2019 Mar 7;19(1):52. Epub 2019 Mar 7.

Health Promotion Administration, Ministry of Health and Welfare, Taipei, Taiwan.

Background: The Global Activity Limitation Indicator (GALI) is a single-item measure of functional decline, it is widely used in Europe but it has never been validated in an Asian population. The aim of this study was to validate the GALI in a sample of older Taiwanese people and to explore whether it captured not only physical but also psychological limitations.

Methods: Data for 4961 individuals (mean age, 62. Read More

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http://dx.doi.org/10.1186/s12874-019-0693-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407180PMC
March 2019
1 Read

Sample size calculation for estimating key epidemiological parameters using serological data and mathematical modelling.

BMC Med Res Methodol 2019 Mar 7;19(1):51. Epub 2019 Mar 7.

Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.

Background: Our work was motivated by the need to, given serum availability and/or financial resources, decide on which samples to test in a serum bank for different pathogens. Simulation-based sample size calculations were performed to determine the age-based sampling structures and optimal allocation of a given number of samples for testing across various age groups best suited to estimate key epidemiological parameters (e.g. Read More

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http://dx.doi.org/10.1186/s12874-019-0692-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407263PMC
March 2019
4 Reads

Additive-multiplicative hazards regression models for interval-censored semi-competing risks data with missing intermediate events.

BMC Med Res Methodol 2019 Mar 6;19(1):49. Epub 2019 Mar 6.

Department of Applied Mathematics, Hanyang University, Ansan, 15588, South Korea.

Background: In clinical trials and survival analysis, participants may be excluded from the study due to withdrawal, which is often referred to as lost-to-follow-up (LTF). It is natural to argue that a disease would be censored due to death; however, when an LTF is present it is not guaranteed that the disease has been censored. This makes it important to consider both cases; the disease is censored or not censored. Read More

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http://dx.doi.org/10.1186/s12874-019-0678-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404346PMC
March 2019
2 Reads

Comparison of methods for early-readmission prediction in a high-dimensional heterogeneous covariates and time-to-event outcome framework.

BMC Med Res Methodol 2019 Mar 6;19(1):50. Epub 2019 Mar 6.

Assistance Publique-Hôpitaux de Paris, Biomedical Informatics and Public Health Department, European Georges Pompidou Hospital, 20 Rue Leblanc, Paris, 75015, France.

Background: Choosing the most performing method in terms of outcome prediction or variables selection is a recurring problem in prognosis studies, leading to many publications on methods comparison. But some aspects have received little attention. First, most comparison studies treat prediction performance and variable selection aspects separately. Read More

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https://bmcmedresmethodol.biomedcentral.com/articles/10.1186
Publisher Site
http://dx.doi.org/10.1186/s12874-019-0673-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404305PMC
March 2019
6 Reads

Assessing correlates of protection in vaccine trials: statistical solutions in the context of high vaccine efficacy.

BMC Med Res Methodol 2019 Mar 6;19(1):47. Epub 2019 Mar 6.

GSK Vaccines, Rue de l'Institut 89, Rixensart, Belgium.

Background: The use of correlates of protection (CoPs) in vaccination trials offers significant advantages as useful clinical endpoint substitutes. Vaccines with very high vaccine efficacy (VE) are documented in the literature (VE ≥95%). The rare events (number of infections) observed in the vaccinated groups of these trials posed challenges when applying conventionally-used statistical methods for CoP assessment. Read More

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http://dx.doi.org/10.1186/s12874-019-0687-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402125PMC

Tools used to assess the quality of peer review reports: a methodological systematic review.

BMC Med Res Methodol 2019 Mar 6;19(1):48. Epub 2019 Mar 6.

Centre d'épidémiologie Clinique, Hôpital Hôtel-Dieu, 1 place du Paris Notre-Dame, 75004, Paris, France.

Background: A strong need exists for a validated tool that clearly defines peer review report quality in biomedical research, as it will allow evaluating interventions aimed at improving the peer review process in well-performed trials. We aim to identify and describe existing tools for assessing the quality of peer review reports in biomedical research.

Methods: We conducted a methodological systematic review by searching PubMed, EMBASE (via Ovid) and The Cochrane Methodology Register (via The Cochrane Library) as well as Google® for all reports in English describing a tool for assessing the quality of a peer review report in biomedical research. Read More

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http://dx.doi.org/10.1186/s12874-019-0688-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402095PMC
March 2019
1 Read

A review of spline function procedures in R.

BMC Med Res Methodol 2019 Mar 6;19(1):46. Epub 2019 Mar 6.

Medical Biometry, Informatics and Epidemiology, Faculty of Medicine, University of Bonn, Bonn, Germany.

Background: With progress on both the theoretical and the computational fronts the use of spline modelling has become an established tool in statistical regression analysis. An important issue in spline modelling is the availability of user friendly, well documented software packages. Following the idea of the STRengthening Analytical Thinking for Observational Studies initiative to provide users with guidance documents on the application of statistical methods in observational research, the aim of this article is to provide an overview of the most widely used spline-based techniques and their implementation in R. Read More

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https://bmcmedresmethodol.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12874-019-0666-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402144PMC
March 2019
4 Reads

Evaluating the effectiveness, efficiency, cost and value of contacting study authors in a systematic review: a case study and worked example.

BMC Med Res Methodol 2019 Mar 5;19(1):45. Epub 2019 Mar 5.

University of Exeter Medical School, PenTAG, Exeter, UK.

Background: Studies find that identifying additional study data is possible by contacting study authors or experts. What is less certain is the time taken, costs involved and value found by using this supplementary search method. The purpose of this study is to determine the effectiveness, efficiency, cost and value of contacting study authors by e-mail, updating the evidence available for this search method. Read More

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http://dx.doi.org/10.1186/s12874-019-0685-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399953PMC

Performance of the WHOQOL-BREF among Norwegian substance use disorder patients.

BMC Med Res Methodol 2019 Mar 4;19(1):44. Epub 2019 Mar 4.

Norwegian Centre for Addiction Research, Institute of Clinical Medicine, University of Oslo, Pb 1039 Blindern, 0315, Oslo, Norway.

Background: Quality of life (QoL) is an established outcome measure of substance use disorder treatment. The WHOQOL-BREF is the gold standard tool, but its appropriateness for particularly vulnerable patient populations must be further explored. This article examines the scaling qualities of the WHOQOL-BREF in a Norwegian substance use disorder population, and explores relationships with social and health variables. Read More

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http://dx.doi.org/10.1186/s12874-019-0690-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399843PMC

Comparison of psychometric properties between recall methods of interview-based physical activity questionnaires: a systematic review.

BMC Med Res Methodol 2019 Mar 1;19(1):43. Epub 2019 Mar 1.

School of Occupational Therapy, Social Work and Speech Pathology, Curtin University, Perth, Western Australia.

Background: This systematic review examined the methodological quality of studies and assessed the psychometric qualities of interview-administered Past-week and Usual-week Physical Activity Questionnaires (PAQs). Pubmed and Embase were used to retrieve data sources.

Methods: The studies were selected using the following eligibility criteria: 1) psychometric properties of PAQs were assessed in adults; 2) the PAQs either consisted of recall periods of usual 7-days (Usual-week PAQs) within the past 12 months or during the past 7-days (Past-week PAQs); and 3) PAQs were interview-administered. Read More

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http://dx.doi.org/10.1186/s12874-019-0684-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396466PMC

Barriers and recruitment strategies for precarious status migrants in Montreal, Canada.

BMC Med Res Methodol 2019 Feb 26;19(1):41. Epub 2019 Feb 26.

University of Montreal Public Health Research Institute (IRSPUM), Montreal, Canada.

Background: Precarious status migrants are a group of persons who are vulnerable, heterogeneous, and often suspicious of research teams. They are underrepresented in population-based research projects, and strategies to recruit them are described exclusively in terms of a single cultural group. We analyzed the recruitment strategies implemented during a research project aimed at understanding precarious status migrants' health status and healthcare access in Montreal, Canada. Read More

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http://dx.doi.org/10.1186/s12874-019-0683-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390306PMC
February 2019
2 Reads

Patient perspectives on use of electronic health records for research recruitment.

BMC Med Res Methodol 2019 Feb 26;19(1):42. Epub 2019 Feb 26.

Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 400, Nashville, TN, 37203, USA.

Background: EHR phenotyping offers the ability to rapidly assemble a precisely defined cohort of patients prescreened for eligibility to participate in health-related research. Even so, stakeholders in the process must still contend with the practical and ethical challenges associated with research recruitment. Patient perspectives on these matters are particularly important given that the success of research recruitment depends on patients' willingness to participate. Read More

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http://dx.doi.org/10.1186/s12874-019-0686-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390331PMC
February 2019

The Chinese version of attitudes towards guidelines scale: validity and reliability assessment.

BMC Med Res Methodol 2019 Feb 22;19(1):40. Epub 2019 Feb 22.

Department of Geriatrics Center, National Clinical Research Center of Geriatrics, West China Hospital, Sichuan University, ChengDu city, China.

Background: The use of guidelines has shown to improve clinical practice process and structure of health care, but health care providers don't always use and keep up-to-date with the new clinical practice guidelines. Nurses' attitudes towards guidelines have shown to be the most frequently identified factor affecting their actual use of clinical practice guidelines, but no instruments for measuring it are available in China. There are scales validated in the western countries, but there is no information about their validity in Chinese health care. Read More

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http://dx.doi.org/10.1186/s12874-019-0682-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387474PMC
February 2019

The key therapeutic factors needed to deliver behavioural change interventions to decrease risky substance use (drug and alcohol) for looked after children and care leavers: a qualitative exploration with young people, carers and front line workers.

BMC Med Res Methodol 2019 Feb 21;19(1):38. Epub 2019 Feb 21.

Institute of Health and Society, Newcastle University, Newcastle Upton Tyne, UK.

Background: Looked after children and care leavers have an increased risk of drug and alcohol use compared to their non-LAC peers. Despite high prevalence rates within this population, looked after children are reported to show low levels of engagement in services resulting in unmet needs emerging from substance use. This paper reports on the initial formative phase of a pilot feasibility randomised controlled trial; SOLID (Supporting Looked After Children and Care Leavers In Decreasing Drugs, and Alcohol) that aimed to adapt two evidence-based psychosocial interventions, Motivational Enhancement Therapy and Social Behaviour and Network Therapy, which will aim to reduce substance misuse by looked after children. Read More

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http://dx.doi.org/10.1186/s12874-019-0674-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385417PMC
February 2019

Strategies for recruitment and retention of underrepresented populations with chronic obstructive pulmonary disease for a clinical trial.

BMC Med Res Methodol 2019 Feb 21;19(1):39. Epub 2019 Feb 21.

Department of Medicine, Division of Primary Care and Population Health, Stanford University, Palo Alto, CA, USA.

Background: Recruitment and retention are two significant barriers in research, particularly for historically underrepresented groups, including racial and ethnic minorities, patients who are low-income, or people with substance use or mental health issues. Chronic obstructive pulmonary disease (COPD) is the third leading cause of death and disproportionately affects many underrepresented groups. The lack of representation of these groups in research limits the generalizability and applicability of clinical research and results. Read More

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http://dx.doi.org/10.1186/s12874-019-0679-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385381PMC
February 2019
1 Read

Aims, design and preliminary findings of the Hellenic National Nutrition and Health Survey (HNNHS).

BMC Med Res Methodol 2019 Feb 20;19(1):37. Epub 2019 Feb 20.

Department of Food Science and Human Nutrition, Agricultural University of Athens, Iera odos 75, 118 55, Athens, Greece.

Background: The aim of the Hellenic National Nutrition and Health Survey was to assess nutritional intake, health status and various behaviors in a representative sample of the Greek population.

Methods: Data collection took place from 01.09. Read More

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http://dx.doi.org/10.1186/s12874-018-0655-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383253PMC
February 2019
1 Read
2.270 Impact Factor

A comparison of the polytomous Rasch analysis output of RUMM2030 and R (ltm/eRm/TAM/lordif).

BMC Med Res Methodol 2019 Feb 20;19(1):36. Epub 2019 Feb 20.

The University of Western Ontario, London, ON, Canada.

Background: Patient-reported outcome measures developed using Classical Test Theory are commonly comprised of ordinal level items on a Likert response scale are problematic as they do not permit the results to be compared between patients. Rasch analysis provides a solution to overcome this by evaluating the measurement characteristics of the rating scales using probability estimates. This is typically achieved using commercial software dedicated to Rasch analysis however, it is possible to conduct this analysis using non-specific open source software such a R. Read More

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http://dx.doi.org/10.1186/s12874-019-0680-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381688PMC
February 2019

A methodological systematic review of meta-ethnography conduct to articulate the complex analytical phases.

BMC Med Res Methodol 2019 Feb 18;19(1):35. Epub 2019 Feb 18.

School of Health Sciences, Bangor University, Bangor, Gwynedd, LL57 2EF, UK.

Background: Decision making in health and social care requires robust syntheses of both quantitative and qualitative evidence. Meta-ethnography is a seven-phase methodology for synthesising qualitative studies. Developed in 1988 by sociologists in education Noblit and Hare, meta-ethnography has evolved since its inception; it is now widely used in healthcare research and is gaining popularity in education research. Read More

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http://dx.doi.org/10.1186/s12874-019-0670-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380066PMC
February 2019

A co-produced method to involve service users in research: the SUCCESS model.

BMC Med Res Methodol 2019 Feb 15;19(1):34. Epub 2019 Feb 15.

Centre for Innovative Ageing, College of Human and Health Science, Swansea University, Swansea, UK.

Background: Public and patient involvement is a routine element of health services research methods to produce better designed and reported studies. Although co-production is recommended when involving people in research, methods for involving people are usually designed and managed by researchers and there is little evidence about methods to co-produce models for effective public and patient involvement. We report the method used by a group of patient and carer service users to develop and implement a model for involving public members in research. Read More

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http://dx.doi.org/10.1186/s12874-019-0671-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377726PMC
February 2019

Assessment of reporting quality of abstracts of systematic reviews with meta-analysis using PRISMA-A and discordance in assessments between raters without prior experience.

BMC Med Res Methodol 2019 Feb 14;19(1):32. Epub 2019 Feb 14.

Center for Evidence-Based Medicine and Health Care, Catholic University of Croatia, Ilica 242, 10000, Zagreb, Croatia.

Background: Reporting quality of systematic reviews' (SRs) abstracts is important because this is often the only information about a study that readers have. The aim of this study was to assess adherence of SR abstracts in the field of anesthesiology with the reporting checklist PRISMA extension for Abstracts (PRISMA-A) and to analyze to what extent will the use of PRISMA-A yield concordant ratings in two raters without prior experience with the checklist.

Methods: We analyzed reporting quality of SRs with meta-analysis of randomized controlled trials of interventions published in the field of anesthesiology from 2012 to 2016 by using 12-item PRISMA-A checklist. Read More

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http://dx.doi.org/10.1186/s12874-019-0675-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376734PMC
February 2019

Dynamic prediction of repeated events data based on landmarking model: application to colorectal liver metastases data.

BMC Med Res Methodol 2019 Feb 14;19(1):31. Epub 2019 Feb 14.

Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: In some clinical situations, patients experience repeated events of the same type. Among these, cancer recurrences can result in terminal events such as death. Therefore, here we dynamically predicted the risks of repeated and terminal events given longitudinal histories observed before prediction time using dynamic pseudo-observations (DPOs) in a landmarking model. Read More

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http://dx.doi.org/10.1186/s12874-019-0677-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376774PMC
February 2019