156,608 results match your criteria BMC Medical Genetics [Journal]


Healthy Life Centre participants' perceptions of living with overweight or obesity and seeking help for a perceived "wrong" lifestyle - a qualitative interview study.

BMC Obes 2018 6;5:42. Epub 2018 Dec 6.

1Faculty of Health and Social Sciences, Department of Health and Caring Science, Western Norway University of Applied Sciences, Bjørnsons gate 45, 5528 Haugesund, Norway.

Background: Overweight and obesity are complex conditions, associated with a wide range of serious health issues. In contemporary society, body size is an important part of a person's self-representation. Lifestyle changes are difficult and long-term weight management is associated with a high risk of failure. Read More

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December 2018

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals.

Clin Epigenetics 2018 Dec 13;10(1):156. Epub 2018 Dec 13.

Latvian Biomedical Research and Study Centre, Ratsupites Str. 1 k-1, Riga, LV-1067, Latvia.

Background: Metformin is a widely prescribed antihyperglycemic agent that has been also associated with multiple therapeutic effects in various diseases, including several types of malignancies. There is growing evidence regarding the contribution of the epigenetic mechanisms in reaching metformin's therapeutic goals; however, the effect of metformin on human cells in vivo is not comprehensively studied. The aim of our study was to examine metformin-induced alterations of DNA methylation profiles in white blood cells of healthy volunteers, employing a longitudinal study design. Read More

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December 2018
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Music therapy intervention in cardiac autonomic modulation, anxiety, and depression in mothers of preterms: randomized controlled trial.

BMC Psychol 2018 Dec 13;6(1):57. Epub 2018 Dec 13.

School of Medicine, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Background: Mothers of preterm infants often have symptoms of anxiety and depression, recognized as risk factors for the development of cardiovascular diseases and associated with low rates of heart rate variability (HRV). This study aimed to evaluate the influence of music therapy intervention on the autonomic control of heart rate, anxiety, and depression in mothers.

Methods: Prospective randomized clinical trial including 21 mothers of preterms admitted to the Neonatal Intensive Care Unit of a tertiary hospital, recruited from August 2015 to September 2017, and divided into control group (CG; n = 11) and music therapy group (MTG; n = 10). Read More

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December 2018

The gingival health status of 8-12 year-old children in Damascus city in Syria during the Syrian Crisis: a cross-sectional epidemiological oral health survey.

BMC Res Notes 2018 Dec 13;11(1):887. Epub 2018 Dec 13.

Paediatric Dentistry Department, Faculty of Dentistry, Damascus University, Damascus, Syria.

Objective: The aim of this study was to assess the current gingival health status in children aged 8-12 years in Damascus city. No contemporary data was available with an immense need for studies evaluating the gingival health status in Syrian children, especially under the current circumstances of the Syrian crisis.

Results: The study followed the school-based health survey model using stratified random cluster sampling. Read More

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December 2018

Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46.

BMC Res Notes 2018 Dec 13;11(1):885. Epub 2018 Dec 13.

MRC Unit for Lifelong Health and Ageing at UCL, London, UK.

Objective: Identifying and recruiting people with early pre-symptomatic Alzheimer's disease to neuroimaging research studies is increasingly important. The extent to which results of these studies can be generalised depends on the recruitment and representativeness of the participants involved. We now report the recruitment and participation patterns from a neuroscience sub-study of the MRC National Survey of Health and Development, "Insight 46". Read More

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December 2018

A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging.

BMC Res Notes 2018 Dec 13;11(1):884. Epub 2018 Dec 13.

Inositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.

Objective: Invertebrates are productive models for understanding how inflammation, metabolism and aging are intertwined. We have deployed a dsRNA library screen to search for genes in Drosophila melanogaster-and hence identify human orthologs-that encode participants in a G-protein coupled, Ca-signaling pathway that regulates inflammation, metabolism and lifespan.

Results: We analyzed receptor-dependent, phospholipase C/Ca signaling responses to the growth-blocking peptide (GBP) cytokine in Drosophila S3 cells plated in 384-well plates containing dsRNAs that target approximately 14,000 Drosophila genes. Read More

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December 2018

The status and health burden of neurocysticercosis in Mbulu district, northern Tanzania.

BMC Res Notes 2018 Dec 13;11(1):890. Epub 2018 Dec 13.

Department of Zoology and Wildlife Conservation, University of Dar es Salaam, P.O. Box 35064, Dar es Salaam, Tanzania.

Objective: The objective of this study was to assess the extent and health burden of neurocysticercosis in the general community of the Mbulu district, northern Tanzania. About 1051 randomly select participants were screened for human cysticercosis. The Cysticercus Western Blot IgG and Computed Tomography scan were used to detect infection by cysticerci. Read More

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December 2018

Uterine fibroids in pregnancy: prevalence, clinical presentation, associated factors and outcomes at the Limbe and Buea Regional Hospitals, Cameroon: a cross-sectional study.

BMC Res Notes 2018 Dec 13;11(1):889. Epub 2018 Dec 13.

Faculty of Health Sciences, University of Buea, P.O.Box 63, Buea, Cameroon.

Objectives: Uterine fibroids are common among the black race and associated with adverse outcomes in pregnancy. The aim of this study was to determine the prevalence, clinical presentation and maternal and foetal outcomes of birth among pregnant women with leiomyoma in two secondary care hospitals in Limbe and Buea, Cameroon.

Results: The prevalence of fibroid in pregnancy was 16. Read More

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December 2018

Hepatitis B vaccination coverage among healthcare workers at a tertiary hospital in Rwanda.

BMC Res Notes 2018 Dec 13;11(1):886. Epub 2018 Dec 13.

Kigali University Teaching Hospital, Kigali, Rwanda.

Objective: We evaluated post-vaccination immunity status and describe potential risk factors associated with the lack of response among healthcare workers (HCWs) at a tertiary care hospital in Kigali, Rwanda.

Results: Of 373 HCWs, 291 (78.2%) were female and 81 (21. Read More

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December 2018

Magnitude of fetal macrosomia and its associated factors at public health institutions of Hawassa city, southern Ethiopia.

BMC Res Notes 2018 Dec 13;11(1):888. Epub 2018 Dec 13.

School of Public Health, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Objectives: This study aimed to determine the magnitude of fetal macrosomia and associated factors at public health institutions of Hawassa city, southern Ethiopia.

Results: In this study, the magnitude of fetal macrosomia found to be 11.86%. Read More

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December 2018
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A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomized controlled trial with 2 year follow-up.

J Transl Med 2018 Dec 13;16(1):355. Epub 2018 Dec 13.

CAPHRI, School of Public Health and Primary Care, Maastricht University, Maastricht, Netherlands.

Background: Cell-based therapies have shown promise for the treatment of knee osteoarthritis (OA). The current study compared exercise therapy to autologous bone marrow concentrate (BMC) and platelet products for knee OA treatment.

Methods: Patients with symptomatic knee OA (N = 48) were randomized into either an exercise therapy control group or treatment group with injection of autologous BMC and platelet products. Read More

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December 2018

Identifying MSM-competent physicians in China: a national online cross-sectional survey among physicians who see male HIV/STI patients.

BMC Health Serv Res 2018 Dec 13;18(1):964. Epub 2018 Dec 13.

Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.

Background: Men who have sex with men (MSM) are at high risk of human immunodeficiency virus (HIV) infection and sexually transmitted infection (STI) in China. Inadequate clinical services and poor clinical competency among physicians are major barriers to improving the sexual health of MSM. This study aims to understand physician clinical competency in providing MSM health services in China. Read More

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December 2018

Catalyzing marketing innovation and competitive advantage in the healthcare industry: the value of thinking like an outsider.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):922. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Marketing arguably is the most critical administrative responsibility associated with the pursuit and realization of growth and prosperity, making prowess in the discipline essential for any healthcare institution, especially given the competitive intensity that characterizes the industry. But in order to truly gain an advantage, healthcare establishments must tap into innovative pathways that their competitors have yet to discover. Here, thinking like an outsider can pay tremendous dividends, as health and medical organizations tend to focus inwardly, limiting their exposure to externally-derived innovations and advancements which often can supply differentiation opportunities. Read More

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December 2018

Healthcare establishments as owner-operators of digital billboards: making the most of excellent roadside visibility and high traffic counts to better connect with patients.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):928. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Given the importance of communicating effectively with current and prospective patients, healthcare institutions must direct considerable energies toward achieving associated excellence. Pursuits usually center on addressing the marketing communications mix properly, but in order to maximize communications prowess, attention also should be directed toward incorporating emerging communications innovations, when and where possible, to bolster opportunities to connect with patients.

Discussion: In pursuit of communications excellence, Willis-Knighton Health System's executives reflected on campus dynamics in the context of modern outdoor advertising technologies, namely, digital billboards, which present electronic advertisements on-demand, around-the-clock. Read More

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December 2018

Reporting guidelines: doing better for readers.

Authors:
David Moher

BMC Med 2018 Dec 14;16(1):233. Epub 2018 Dec 14.

Centre for Journalology, Clinical Epidemiology Program, The Ottawa Hospital Research Institute, The Ottawa Hospital - General Campus, 501 Smyth Rd, Room L1288, Ottawa, ON, K1H 8L6, Canada.

There is clear guidance on the responsibilities of editors to ensure that the research they publish is of the highest possible quality. Poor reporting is unethical and directly impacts patient care. Reporting guidelines are a relatively recent development to help improve the accuracy, clarity, and transparency of biomedical publications. Read More

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December 2018

Transcriptomic analysis reveals that enterovirus F strain SWUN-AB001 infection activates JNK/SAPK and p38 MAPK signaling pathways in MDBK cells.

BMC Vet Res 2018 Dec 13;14(1):395. Epub 2018 Dec 13.

College of Life Science and Technology, Southwest Minzu University, No.16, South 4th Section 1st Ring Road, Chengdu, 610041, China.

Background: Enteroviruses (Picornaviridae family) have been widely detected in the feces from cattle with diarrhea. However, the mechanisms responsible for the pathogenicity of enteroviruses in cattle remain unclear. Recently, we isolated a novel EV-F7 strain called SWUN-AB001 from diarrheal yak (Bos grunniens) feces. Read More

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December 2018

Driving brand equity in health services organizations: the need for an expanded view of branding.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):924. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Branding-the assignment of names, logos, slogans, and related elements of identity to institutions and their product offerings for the purpose of conveying desired images to target audiences-is of paramount importance in the health services industry. Associated initiatives traditionally have centered on developing verbal and visual brand expressions, but opportunities abound to drive brand equity by supplementing traditional pursuits with new, different, and unexpected expressions that afford highly memorable experiences.

Discussion: Willis-Knighton Health System has possessed an expanded view of branding for decades. Read More

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December 2018

A cross-sectional study into medical students' perceptions of healthcare regulation and self-reported compliance: a study conducted in the City of Al Ain, United Arab Emirates, 2016.

BMC Med Educ 2018 Dec 13;18(1):305. Epub 2018 Dec 13.

Medisch Centrum Twente, Enschede, The Netherlands.

Background: Although healthcare regulation is commonplace, there is limited evidence of its impact. Making sure that healthcare professionals comply with the regulatory requirements is a prerequisite to achieving effective regulation. Therefore, investigating factors that influence compliance may provide better insights into how regulators can be more effective. Read More

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December 2018

Consequences of community water fluoridation cessation for Medicaid-eligible children and adolescents in Juneau, Alaska.

BMC Oral Health 2018 Dec 13;18(1):215. Epub 2018 Dec 13.

Public Health Programs, School of Health Sciences, College of Health Sciences, Walden University, 100 Washington Ave. South, Suite 900, Minneapolis, MN, 55401, USA.

Background: The general aim of this research was to determine whether cessation of community water fluoridation (CWF) increased oral health disparities, as measured by dental caries procedures and restoration costs for children and adolescents.

Methods: The analysis was based on all Medicaid dental claims records of 0- to 18-year-old patients residing in zip code 99801 (Juneau, Alaska) during an optimal CWF year (2003, n = 853) compared to all claims for the same age group from 2012 (n = 1052), five years after cessation of CWF. A bivariate analysis (Mann-Whitney U test) of the mean number of caries procedures performed per client was conducted in the study groups under both independent CWF conditions. Read More

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December 2018

Trait heritability in major transitions.

BMC Biol 2018 Dec 13;16(1):145. Epub 2018 Dec 13.

School of Biological Sciences, Georgia Institute of Technology, North Avenue, Atlanta, GA, 30332, USA.

Background: Increases in biological complexity and the origins of life's hierarchical organization are described by the "major transitions" framework. A crucial component of this paradigm is that after the transition in complexity or organization, adaptation occurs primarily at the level of the new, higher-level unit. For collective-level adaptations to occur, though, collective-level traits-properties of the group, such as collective size-must be heritable. Read More

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December 2018

Am I seeing things through the eyes of patients? An exercise in bolstering patient attentiveness and empathy.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):929. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Modern marketing thought heavily emphasizes the need for healthcare providers to possess a customer orientation, placing patients at the focal point of attention within health and medical establishments. This has motivated significant investments in tools and techniques that foster outstanding service, attention, and support. Such investments in isolation, however, offer no guarantees that a true customer orientation will emerge. Read More

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December 2018

Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach.

BMC Complement Altern Med 2018 Dec 13;18(1):332. Epub 2018 Dec 13.

Global Research Laboratory, Department of BioSciences, and Engineering, Konkuk University Seoul, Seoul, South Korea.

Background: The fruit of Elaeagnus umbellata has high medicinal values and is an excellent source of phytochemicals. This study was aimed to evaluate the antioxidant, enzyme inhibitory and antidiabetic potential of Elaeagnus umbellata.

Methods: The antioxidant potential of the crude extract and subfractions of E. Read More

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December 2018

Correction to: Frailty, nutrition-related parameters, and mortality across the adult age spectrum.

BMC Med 2018 Dec 14;16(1):235. Epub 2018 Dec 14.

Centre for Health Care of the Elderly, QEII Health Sciences Centre, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.

The original article [1] contained an error whereby Table 5 within the Appendix is presented incorrectly. This error has now been corrected and Table 5 is presented appropriately. Read More

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December 2018

Target marketing in the health services industry: the value of journeying off the beaten path.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):923. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Target marketing, a practice used to more effectively address the wants and needs of customers, involves three interrelated activities: market segmentation, targeting, and product positioning. The practice follows a perfectly logical process. For a given offering, healthcare institutions select a desired group to pursue and arrange service characteristics and related attributes in a manner to entice that particular group to forward patronage and become customers. Read More

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December 2018

Herbal medicine use by pregnant women in Bangladesh: a cross-sectional study.

BMC Complement Altern Med 2018 Dec 13;18(1):333. Epub 2018 Dec 13.

Institute of Health Services Management, Hanyang University, Seoul, South Korea.

Background: Herbal medicines in pregnancy are increasingly used worldwide with prevalence of up to 67%. Although this popularity is mainly because of the common belief that these medicines are safe, recent reports suggest that several herbal medicines are potentially harmful to mother and fetus if used in pregnancy.

Methods: This cross-sectional study was conducted in July and August of year 2017, at maternity wards of two public hospitals in Dhaka, Bangladesh. Read More

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December 2018

Engaging patients, enhancing patient experiences: insights, innovations, and applications.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):925. Epub 2018 Dec 14.

Department of Health Services Administration, University of Alabama at Birmingham, School of Health Professions Building, 5th Floor, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.

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December 2018

Establishing Good Samaritan programs in healthcare institutions: a method for enhancing patient experiences and increasing loyalty.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):927. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Healthcare institutions deliver essential services that practically everyone needs at least periodically over the course of their lives. Hospital admissions, in particular, place patients in circumstances very foreign to them, with uncertain outcomes often being the case, causing stress for care recipients and their loved ones. Health and medical establishments must be very mindful of this and work toward supplying environments that are as comforting as possible for those in their care. Read More

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December 2018

Embedding sports and exercise medicine into the medical curriculum; a call for inclusion.

BMC Med Educ 2018 Dec 13;18(1):306. Epub 2018 Dec 13.

University of Sheffield Medical School, University of Sheffield, Sheffield, UK.

The UK is currently facing an inactivity crises, with 1 in 5 children currently meeting physical activity guidelines (Health Survey for England, Children's Health, 2016). To combat this growing problem there has been increased interest in promoting exercise and healthy lifestyle advise to patients as a method for improving public health. In line with this, the specialty of Sports and Exercise Medicine (SEM) has been gaining momentum and is now a recognised specialty with a higher specialist training programme. Read More

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December 2018

Formulating productive marketing communications strategy: a major health system's experience.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):926. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Healthcare establishments serve as key community resources, bringing into locales a wealth of resources aimed at enhancing and improving health and wellness. Without effective communications, current and prospective patients will remain unaware of available offerings, foiling opportunities for mutually beneficial exchange. Today, healthcare organizations engage audiences by selecting from among the components of the marketing communications mix, but this wasn't always the case. Read More

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December 2018

Infection-free rates and Sequelae predict factors in bone transportation for infected tibia: a systematic review and meta-analysis.

BMC Musculoskelet Disord 2018 Dec 13;19(1):442. Epub 2018 Dec 13.

Department of Orthopedics, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan Province, China.

Background: Tibia infected nonunion and chronic osteomyelitis are challenging clinical presentations. Bone transportation with external or hybrid fixators (combined external and internal fixators) is versatile to solve these problems. However, the infection-free rates of these fixator systems are unknown. Read More

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December 2018

Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case report.

BMC Cancer 2018 Dec 13;18(1):1249. Epub 2018 Dec 13.

Department of Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan.

Background: Thymomas are typically slow-growing tumors and AB type thymomas are considered no/low risk tumors with a better prognosis. Extra-thoracic metastases are extremely rare. To the best of our knowledge, no patient with an isolated splenic metastasis from a thymoma has been reported. Read More

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December 2018
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The changing landscape of phase II/III metastatic sarcoma clinical trials-analysis of ClinicalTrials.gov.

BMC Cancer 2018 Dec 13;18(1):1251. Epub 2018 Dec 13.

Department of Medical Melanoma and Sarcoma, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 East Dongfeng Road, Guangzhou, 510060, China.

Background: Well-designed clinical trials are of great importance in validating novel treatments and ensuring an evidence-based approach for sarcoma. This study aimed to provide a comprehensive landscape of the characteristics of metastatic or advanced sarcoma clinical trials using the substantial resource of the ClincialTrials.gov database. Read More

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December 2018

Proposal for a screening questionnaire for detecting habitual mouth breathing, based on a mouth-breathing habit score.

BMC Oral Health 2018 Dec 13;18(1):216. Epub 2018 Dec 13.

Department of Oral Biomedical Research, Total Health Advisers Co., Chiba-shi, Chiba, Japan.

Background: When mouth breathing becomes habitual, it can cause sleep disorders and abnormal maxillofacial growth, thus early detection of habitual mouth breathing is important. We created a questionnaire for early detection of habitual mouth breathing using a score based on a spectrum of factors found to be characteristic of mouth breathers.

Methods: First, a draft 50-question questionnaire was given to 101 random dental clinic patients, classified by dental professionals into habitual mouth breathers (n = 28) and nose breathers (n = 73). Read More

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December 2018

The evaluation of nocturia in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia and the analysis of the curative effect after medical or placebo therapy for nocturia: a randomized placebo-controlled study.

BMC Urol 2018 Dec 13;18(1):115. Epub 2018 Dec 13.

Department of Urology, Beijing Huairou Hospital, Beijing, 101400, China.

Background: To study nocturia in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) after medical or placebo treatment.

Methods: Patients with LUTS suggestive of BPH from several community clinics were included. Patients completed the International Prostate Symptom Score (I-PSS) questionnaire and a 3-day voiding diary. Read More

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December 2018

Knowledge, perceptions, and clinical experiences on molar incisor hypomineralization among dental care providers in Hong Kong.

BMC Oral Health 2018 Dec 13;18(1):217. Epub 2018 Dec 13.

Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong, SAR, China.

Background: Molar incisor hypomineralization (MIH) is an alarming problem with considerable challenges in management. This study aimed to evaluate and compare the knowledge, perceptions, and clinical experiences of molar incisor hypomineralization (MIH) between general dental practitioners (GDPs) and paediatric dentists (PDs) in Hong Kong.

Methods: A cross-sectional survey of 557 randomly selected GDPs (approximately 25% of all registered dentists) and all registered PDs (n = 31) were invited. Read More

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December 2018

Correction to: Maternal personality disorder symptoms in primary health care: associations with mother-toddler interactions at one-year follow-up.

BMC Psychiatry 2018 Dec 13;18(1):387. Epub 2018 Dec 13.

The Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway.

Following publication of the original article. Read More

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December 2018

Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 Å resolution.

BMC Struct Biol 2018 Dec 13;18(1):17. Epub 2018 Dec 13.

School of Biology, Faculty of Biology Medicine and Health, Michael Smith Building, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Background: P-glycoprotein (ABCB1) is an ATP-binding cassette transporter that plays an important role in the clearance of drugs and xenobiotics and is associated with multi-drug resistance in cancer. Although several P-glycoprotein structures are available, these are either at low resolution, or represent mutated and/or quiescent states of the protein.

Results: In the post-hydrolytic state the structure of the wild-type protein has been resolved at about 8 Å resolution. Read More

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December 2018

New regression equations for mixed dentition space analysis in Nepalese mongoloids.

BMC Oral Health 2018 Dec 13;18(1):214. Epub 2018 Dec 13.

Department of Orthodontics, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Background: Mixed dentition space analysis methods using regression equations, namely, Moyers' analysis and Tanaka-Johnston analysis are commonly used around the world. However, the applicability of these analyses among different racial groups have been questioned. The primary objective of this study was to assess the applicability of the Moyers' and Tanaka-Johnston analyses among Nepalese Mongoloids and to develop regression equations for the same population if needed. Read More

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December 2018

Sequential treatment of ADHD in mother and child (AIMAC study): importance of the treatment phases for intervention success in a randomized trial.

BMC Psychiatry 2018 Dec 13;18(1):388. Epub 2018 Dec 13.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Würzburg, Würzburg, Germany.

Background: The efficacy of parent-child training (PCT) regarding child symptoms may be reduced if the mother has attention-deficit/hyperactivity disorder (ADHD). The AIMAC study (ADHD in Mothers and Children) aimed to compensate for the deteriorating effect of parental psychopathology by treating the mother (Step 1) before the beginning of PCT (Step 2). This secondary analysis was particularly concerned with the additional effect of the Step 2 PCT on child symptoms after the Step 1 treatment. Read More

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December 2018

The effect of smear layer removal on E. faecalis leakage and bond strength of four resin-based root canal sealers.

BMC Oral Health 2018 Dec 13;18(1):213. Epub 2018 Dec 13.

Department of Clinical Dentistry, Faculty of Health Sciences, UiT The Arctic University of Norway, N-9037, Tromso, Norway.

Background: The aim of the study was to assess bacterial sealability and bonding ability of methacrylate-based Resilon (RS, SybronEndo), Endo Rez (ER, Ultradent Products Inc), and epoxy-based AH Plus (AH, Dentsply/DeTrey), MTA Fill Apex (MTAF, Angelus Soluções Odontológicas) root canal sealers, and the effect of the smear layer removal on the sealability.

Methods: One hundred thirty root segments were instrumented up to apical size #60 and rinsed with 2.5% NaOCl. Read More

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December 2018

Safety and efficacy of cytotoxic chemotherapy in hepatocellular carcinoma after first-line treatment with sorafenib.

BMC Cancer 2018 Dec 13;18(1):1250. Epub 2018 Dec 13.

Instituto do Cancer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, Av Dr Arnaldo, 251, São Paulo, ZIP code: 01246-000, Brazil.

Background: Before the targeted therapies era, cytotoxic chemotherapy (CCT) was an option for advanced hepatocellular carcinoma (HCC), even with the lack of supporting evidence. Since the last decade, sorafenib has been established as the first-line therapy. Although new agents are being incorporated, CCT is still considered in regions where new drugs are not available or for patients who progressed through the approved therapies and remain in good clinical condition. Read More

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December 2018

The incidence, risk factors and outcomes of early bloodstream infection in patients with malignant hematologic disease after unrelated cord blood transplantation: a retrospective study.

BMC Infect Dis 2018 Dec 13;18(1):654. Epub 2018 Dec 13.

Department of Hematology of Anhui Provincial Hospital, Anhui Medical University, 17 Lujiang Road, Hefei, 230001, Anhui, China.

Background: Bloodstream infection (BSI) is one of the major causes of morbidity and mortality for patients undergoing hematopoietic stem cell transplantation (HSCT). The unrelated cord blood transplantation (UCBT) can provided opportunities for patients without suitable donors for bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT), while few studies have addressed BSI after UCBT. The aim of this study was to analyse the incidence and risk factors of BSI, causative organisms, microbial resistance, and its impact on the clinical outcomes and survival of patients. Read More

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December 2018

Iron supplementation during pregnancy - a cross-sectional study undertaken in four German states.

BMC Pregnancy Childbirth 2018 Dec 13;18(1):491. Epub 2018 Dec 13.

Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany.

Background: Iron deficiency but also iron overload during pregnancy has been associated with unwanted health effects. In Germany, iron supplements are only recommended for pregnant women with diagnosed iron deficiency/anaemia. Prevalence of anaemia among pregnant women was reported at 24. Read More

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December 2018

Examining trends in inequality in the use of reproductive health care services in Ghana and Nigeria.

BMC Pregnancy Childbirth 2018 Dec 13;18(1):492. Epub 2018 Dec 13.

Department of Health Services Research, CAPHRI, Maastricht University Medical Center, Faculty of Health, Medicine and Life Sciences, Maastricht University, PO Box 616, 6200MD, Maastricht, The Netherlands.

Background: Equitable use of reproductive health care services is of critical importance since it may affect women's and children's health. Policies to reduce inequality in access to reproductive health care services are often general and frequently benefit the richer population. This is known as the inverse equity situation. Read More

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December 2018

Simultaneous multi-slice MR imaging of the hip at 3 T to reduce acquisition times and maintain image quality.

BMC Musculoskelet Disord 2018 Dec 13;19(1):440. Epub 2018 Dec 13.

Department of Radiology, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.

Background: Newly developed simultaneous multi-slice (SMS) scans are now being introduced as a clinical application in neuroimaging. We examined the feasibility of SMS scans for joint imaging. The purpose of the present study was to prospectively compare the resolution and specific absorption rate (SAR) obtained using SMS to those of conventional methods in hip joint magnetic resonance imaging (MRI) and establish whether imaging times may be reduced using SMS in 3 T MRI and if image quality is affected. Read More

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December 2018

Prognostic effect of factors involved in revised Tokuhashi score system for patients with spinal metastases: a systematic review and Meta-analysis.

BMC Cancer 2018 Dec 13;18(1):1248. Epub 2018 Dec 13.

Tianjin Medical university, Tianjin, 300070, China.

Background: Cancer patients' survival time has obviously improved, with the development of systemic treatment techniques. However, the probability of metastases to the vertebrae has also been increased which makes some adverse effects on patients' quality of life. The prediction of survival plays a key role in choosing therapeutic modality, and Tokuhashi Score was established as one of the most commonly used predictive systems for spinal metastases. Read More

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December 2018

Unintended pregnancy is a risk factor for depressive symptoms among socio-economically disadvantaged women in rural Bangladesh.

BMC Pregnancy Childbirth 2018 Dec 13;18(1):490. Epub 2018 Dec 13.

Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St., Room E2519, Baltimore, MD, 21205-2179, USA.

Background: Little is known about the relation between unwanted pregnancy and intention discordance and maternal mental health in low-income countries. The study aim was to evaluate maternal and paternal pregnancy intentions (and intention discordance) in relation to perinatal depressive symptoms among rural Bangladeshi women.

Methods: Data come from a population-based, community trial of married rural Bangladeshi women aged 13-44. Read More

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December 2018

Retinal fluid changes and therapeutic effects in symptomatic circumscribed choroidal hemangioma patients: a long-term follow up study.

BMC Ophthalmol 2018 Dec 13;18(1):321. Epub 2018 Dec 13.

Department of Ophthalmology, Eye and ENT Hospital, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Background: Changes in retinal fluid patterns associated with circumscribed choroidal hemangioma (CCH) have not been investigated yet. A long-term follow-up study was performed to evaluate the changes of retinal fluid patterns and treatment responses.

Methods: We retrospectively reviewed medical records of all CCH patients diagnosed between November 2005 and March 2017. Read More

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December 2018

Association between random glucose and all-cause mortality: findings from the mortality follow-up of the German National Health Interview and Examination Survey 1998.

BMC Endocr Disord 2018 Dec 13;18(1):95. Epub 2018 Dec 13.

Department of Epidemiology and Health Monitoring, Robert Koch Institute, General-Pape-Strasse 62-66, D-12101, Berlin, Germany.

Background: Random glucose is widely measured in epidemiological studies and in the clinical setting when standardized fasting protocols and oral glucose tolerance testing or HbA measuring are not feasible. The relationship between random glucose and all-cause mortality has hardly been studied so far and was examined in the present study.

Methods: We ascertained mortality status among 5955 persons aged 18-79 years and free of known diabetes when participating in the German National Health Interview and Examination Survey 1998 (mean observation time 11. Read More

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December 2018

The association between active tobacco use during pregnancy and growth outcomes of children under five years of age: a systematic review and meta-analysis.

BMC Public Health 2018 Dec 13;18(1):1372. Epub 2018 Dec 13.

Nutrition Innovation, PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA, 98121, USA.

Background: Despite considerable global efforts to reduce growth faltering in early childhood, rates of stunting remain high in many regions of the world. Current interventions primarily target nutrition-specific risk factors, but these have proven insufficient. The objective of this study was to synthesize the evidence on the relationship between active tobacco use during pregnancy and growth outcomes in children under five years of age. Read More

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December 2018