845 results match your criteria BMC Immunology[Journal]


Patients with idiopathic recurrent miscarriage have abnormally high TGFß+ blood NK, NKT and T cells in the presence of abnormally low TGFß plasma levels.

BMC Immunol 2019 03 4;20(1):10. Epub 2019 Mar 4.

Transplantation Immunology, Institute of Immunology, University Hospital Heidelberg, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany.

Background: Previously, we demonstrated up-regulated activated CD4+ and CD8+ T lymphocytes as well as up-regulated cytotoxic NK cells in the blood of patients with idiopathic recurrent miscarriage. In the present study, we tried to identify deficiencies in counter-regulating immune mechanisms of these patients.

Method: Cytokines were determined in NK cells and in plasma samples of 35 healthy controls, 33 patients with idiopathic recurrent miscarriage, 34 patients with end stage renal disease, 10 transplant patients early and 37 transplant patients late post-transplant using flow-cytometry and luminex. Read More

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https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865
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http://dx.doi.org/10.1186/s12865-019-0290-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399890PMC
March 2019
6 Reads

Active immunization with norovirus P particle-based amyloid-β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice.

BMC Immunol 2019 02 12;20(1). Epub 2019 Feb 12.

National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.

Background: Active immunotherapy targeting amyloid-β (Aβ) is a promising treatment for Alzheimer's disease (AD). Numerous preclinical studies and clinical trials demonstrated that a safe and effective AD vaccine should induce high titers of anti-Aβ antibodies while avoiding the activation of T cells specific to Aβ.

Results: An untagged Aβ1-6 chimeric protein vaccine against AD based on norovirus (NoV) P particle was expressed in Escherichia coli and obtained by sequential chromatography. Read More

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http://dx.doi.org/10.1186/s12865-019-0289-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373079PMC
February 2019
1 Read

Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function.

BMC Immunol 2019 01 29;20(1). Epub 2019 Jan 29.

Research Institute of the McGill University Health Center, Glen Site, 1001 Décarie Boulevard, Block E, Rm EM3.3238, Montréal, Québec, H4A 3J1, Canada.

Background: Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors. Human Leukocyte Antigen null cells are used in vitro to stimulate natural killer cell activation through missing-self mechanisms. On the other hand, CEM. Read More

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http://dx.doi.org/10.1186/s12865-018-0272-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352444PMC
January 2019
6 Reads

CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.

BMC Immunol 2019 01 23;20(1). Epub 2019 Jan 23.

Department of Molecular Imaging and Therapy, Beckman Research Institute of City of Hope, 1500E Duarte Road, Duarte, CA91010, USA.

Background: Systemic inflammation and the fever response to pathogens are coordinately regulated by IL-6 and IL-1β. We previously showed that CEACAM1 regulates the LPS driven expression of IL-1β in murine neutrophils through its ITIM receptor.

Results: We now show that the prompt secretion of IL-6 in response to LPS is regulated by CEACAM1 expression on bone marrow monocytes. Read More

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http://dx.doi.org/10.1186/s12865-019-0287-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345024PMC
January 2019
1 Read
2.481 Impact Factor

Monoclonal antibody against EV71 3D inhibits the polymerase activity of RdRp and virus replication.

BMC Immunol 2019 01 22;20(1). Epub 2019 Jan 22.

Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, People's Republic of China.

Background: Enterovirus A 71 (EV71) is a neurotropic virus that may lead to acute flaccid paralysis, encephalitis, cardiopulmonary failure or even death. No vaccine and defensive drug controlling EV71 is currently available, novel and efficient antiviral drug or vaccine is therefore urgently needed. 3D (RNA-dependent RNA polymerase (RdRp)) has been an important target for anti-EV71 drug development. Read More

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http://dx.doi.org/10.1186/s12865-019-0288-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343263PMC
January 2019
3 Reads

Phenotypic and functional stability of leukocytes from human peripheral blood samples: considerations for the design of immunological studies.

BMC Immunol 2019 01 18;20(1). Epub 2019 Jan 18.

Centro Internacional de Entrenamiento e Investigaciones Médicas-CIDEIM, Cali, Colombia.

Background: Human peripheral blood mononuclear cells (PBMCs) are extensively used for research of immune cell functions, identification of biomarkers and development of diagnostics and therapeutics for human diseases, among others. The assumption that "old blood samples" are not appropriate for isolation of PBMCs for functional assays has been a dogma in the scientific community. However, partial data on the impact of time after phlebotomy on the quality and stability of human PBMCs preparations impairs the design of studies in which time-controlled blood sampling is challenging such as field studies involving multiple sampling centers/sites. Read More

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http://dx.doi.org/10.1186/s12865-019-0286-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339328PMC
January 2019
1 Read

Correlate tumor mutation burden with immune signatures in human cancers.

BMC Immunol 2019 01 11;20(1). Epub 2019 Jan 11.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.

Background: Tumor mutation burden (TMB) has been associated with cancer immunotherapeutic response and cancer prognosis. Although many explorations have revealed that high TMB may yield many neoantigens to incite antitumor immune response, a systematic exploration of the correlation between TMB and immune signatures in different cancer types is lacking.

Results: We classified cancer into the lower-TMB subtype and the higher-TMB subtype for each of 32 cancer types based on their somatic mutation data from the Cancer Genome Atlas (TCGA), and compared the expression levels of immune-related genes and gene-sets between both subtypes of cancers in each cancer type. Read More

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http://dx.doi.org/10.1186/s12865-018-0285-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329192PMC
January 2019
10 Reads

Treatment of established TH2 cells with 4μ8c, an inhibitor of IRE1α, blocks IL-5 but not IL-4 secretion.

BMC Immunol 2019 01 10;20(1). Epub 2019 Jan 10.

Department of Natural Sciences, Northeastern State University, 3100 New Orleans Street, Broken Arrow, OK, 74014, USA.

Background: T cell activation induces ER stress and upregulates Inositol Requiring Enzyme 1 alpha (IRE1α), an activator of the unfolded protein response (UPR) pathway. Inhibition of IRE1α RNase activity in activated CD4 splenocytes from naïve mice, via treatment of the cells with the commercially available drug 4μ8c upon activation, results in the reduction of the secretion of proteins IL-5, IL-4, and IL-13. Prior to this work, it was unknown if 4μ8c could inhibit TH2 cytokines in established TH2 cells, cells that are crucial in promoting disease in severe asthma. Read More

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http://dx.doi.org/10.1186/s12865-018-0283-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327572PMC
January 2019
12 Reads

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection.

BMC Immunol 2019 01 7;20(1). Epub 2019 Jan 7.

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Background: The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases such as HIV-1 and to investigate multiple aspects of human immune system development. However, mouse and human are different in sialylation patterns of proteins due to evolutionary mutations of the CMP-N-acetylneuraminic acid hydroxylase (CMAH) gene that prevent formation of N-glycolylneuraminic acid from N-acetylneuraminic acid. How changes in the mouse glycoproteins' chemistry affect phenotype and function of transplanted human hematopoietic stem cells and mature human immune cells in the course of HIV-1 infection are not known. Read More

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http://dx.doi.org/10.1186/s12865-018-0279-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322283PMC
January 2019
5 Reads
2.481 Impact Factor

Mannose-binding lectin concentrations in people living with HIV/AIDS infected by HHV-8.

BMC Immunol 2019 01 3;20(1). Epub 2019 Jan 3.

Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Background: Mannose-binding lectin (MBL) plays an important role in the innate immune response by activating the complement system via the lectin pathway, and it has been studied in several viral infections; however, the influence of MBL in PLWHA infected with HHV-8 is unknown. The objective of this study was to verify the association of MBL deficient plasma concentrations in HIV/HHV-8 coinfected and HIV monoinfected patients and to correlate these concentrations with HIV viral load and CD4 counts in both groups.

Results: This was an analytical study of case-controls consisting of PLWHA monitored at the medical outpatient of Infectious and Parasitic Diseases of the clinical hospital in the Federal University of Pernambuco. Read More

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http://dx.doi.org/10.1186/s12865-018-0284-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318849PMC
January 2019
12 Reads

Variation in IL-21-secreting circulating follicular helper T cells in Kawasaki disease.

BMC Immunol 2018 12 27;19(1):43. Epub 2018 Dec 27.

Department of Pediatric Rheumatology and Allergy, The First Hospital of Jilin University, Changchun, 130021, China.

Objective: Circulating follicular helper T (cTfh) cells are a specialized subset of CD4 T cells that express the CXC-chemokine receptor 5 (CXCR5). These cells exhibit immune activities by inducing B cell differentiation and proliferation via the secretion of interleukin (IL)-21. Multiple studies have demonstrated that cTfh cells are associated with the progression and severity of numerous diseases. Read More

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http://dx.doi.org/10.1186/s12865-018-0282-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307283PMC
December 2018
24 Reads
2.481 Impact Factor

Correction to: blood handling and leukocyte isolation methods impact the global transcriptome of immune cells.

BMC Immunol 2018 12 21;19(1):42. Epub 2018 Dec 21.

Department of Biological Engineering, Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

It has been highlighted that the original article [1] contained a typesetting mistake in the middle name of Arthur F. Steinschneider. Read More

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http://dx.doi.org/10.1186/s12865-018-0273-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303977PMC
December 2018
1 Read

5-Aminolevulinic acid regulates the immune response in LPS-stimulated RAW 264.7 macrophages.

BMC Immunol 2018 12 19;19(1):41. Epub 2018 Dec 19.

School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan.

Background: Macrophages are crucial players in a variety of inflammatory responses to environmental cues. However, it has been widely reported that macrophages cause chronic inflammation and are involved in a variety of diseases, such as obesity, diabetes, metabolic syndrome, and cancer. In this study, we report the suppressive effect of 5-aminolevulinic acid (ALA), via the HO-1-related system, on the immune response of the LPS-stimulated mouse macrophage cell line RAW264. Read More

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https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865
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http://dx.doi.org/10.1186/s12865-018-0277-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300011PMC
December 2018
13 Reads

Oncolytic herpes simplex virus and immunotherapy.

BMC Immunol 2018 12 18;19(1):40. Epub 2018 Dec 18.

Ruminant Diseases Research Center, Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, 250014, China.

Background: Oncolytic viruses have been proposed to be employed as a potential treatment of cancer. Well targeted, they will serve the purpose of cracking tumor cells without causing damage to normal cells. In this category of oncolytic viral drugs human pathogens herpes simplex virus (HSV) is especially suitable for the cause. Read More

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http://dx.doi.org/10.1186/s12865-018-0281-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299639PMC
December 2018
1 Read

Human NK cells adapt their immune response towards increasing multiplicities of infection of Aspergillus fumigatus.

BMC Immunol 2018 12 18;19(1):39. Epub 2018 Dec 18.

Department of Internal Medicine II, WÜ4i, University Hospital Wuerzburg, Wuerzburg, Germany.

Background: The saprophytic fungus Aspergillus fumigatus reproduces by generation of conidia, which are spread by airflow throughout nature. Since humans are inhaling certain amounts of spores every day, the (innate) immune system is constantly challenged. Even though macrophages and neutrophils carry the main burden, also NK cells are regarded to contribute to the antifungal immune response. Read More

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http://dx.doi.org/10.1186/s12865-018-0276-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299526PMC
December 2018
5 Reads

Prevalence and associated factors of treatment failure among HIV/AIDS patients on HAART attending University of Gondar Referral Hospital Northwest Ethiopia.

BMC Immunol 2018 12 17;19(1):37. Epub 2018 Dec 17.

Departhement of Medical Microbiology college of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: The initiation of highly active antiretroviral therapy (HAART) plays a significant role in the clinical management of HIV infected people by preventing morbidity and mortality. This benefit becomes, the most terrible when treatment failure develops. Thus, this research aims to assess the prevalence and associated factors of treatment failure among HIV/AIDS patients on HAART attending University of Gondar Referral Hospital Northwest Ethiopia. Read More

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http://dx.doi.org/10.1186/s12865-018-0278-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296084PMC
December 2018
4 Reads

Anti-SIRT1 autoantibody is elevated in ankylosing spondylitis: a potential disease biomarker.

BMC Immunol 2018 12 17;19(1):38. Epub 2018 Dec 17.

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Second Road, Shanghai, 200025, China.

Background: Little is known about the presence of specific autoantibodies in ankylosing spondylitis (AS), an immune-mediated inflammatory disease. The object of this study was to explore potential autoantibody profiles in AS patients.

Results: Levels of anti-SIRT1 autoantibodies were significantly higher in AS (P < 0. Read More

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http://dx.doi.org/10.1186/s12865-018-0280-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298004PMC
December 2018
14 Reads
2.481 Impact Factor

Small-intestinal TG2-specific plasma cells at different stages of coeliac disease.

BMC Immunol 2018 12 6;19(1):36. Epub 2018 Dec 6.

Celiac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, P.O. Box 100, 33014, Tampere, Finland.

Background: In coeliac disease, ingestion of gluten induces the production of transglutaminase 2 (TG2)-targeted autoantibodies by TG2-specific plasma cells present at high frequency in the small intestinal mucosa in untreated disease. During treatment with a gluten-free diet (GFD), the number of these cells decreases considerably. It has not been previously investigated whether the cells are also present prior to development of villous atrophy, or in non-responsive patients and those with dietary lapses. Read More

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http://dx.doi.org/10.1186/s12865-018-0275-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282384PMC
December 2018
4 Reads

A novel approach for rapid high-throughput selection of recombinant functional rat monoclonal antibodies.

BMC Immunol 2018 12 4;19(1):35. Epub 2018 Dec 4.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361102, China.

Background: Most monoclonal antibodies against mouse antigens have been derived from rat spleen-mouse myeloma fusions, which are valuable tools for purposes ranging from general laboratory reagents to therapeutic drugs, and yet selecting and expressing them remains a time-consuming and inefficient process. Here, we report a novel approach for the rapid high-throughput selection and expression of recombinant functional rat monoclonal antibodies with different isotypes.

Results: We have developed a robust system for generating rat monoclonal antibodies through several processes involving simultaneously immunizing rats with three different antigens expressing in a mixed cell pools, preparing hybridoma cell pools, in vitro screening and subsequent cloning of the rearranged light and heavy chains into a single expression plasmid using a highly efficient assembly method, which can decrease the time and effort required by multiple immunizations and fusions, traditional clonal selection and expression methods. Read More

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http://dx.doi.org/10.1186/s12865-018-0274-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280491PMC
December 2018
18 Reads

Characterization of anti-EBA175RIII-V in asymptomatic adults and children living in communities in the Greater Accra Region of Ghana with varying malaria transmission intensities.

BMC Immunol 2018 11 19;19(1):34. Epub 2018 Nov 19.

Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.

Background: Antibodies against Region III-V of the erythrocyte binding antigen (EBA) 175 (EBA175RIII-V) have been suggested to provide protection from malaria in a natural infection. However, the quality and quantity of naturally induced antibodies to EBA175RIII-V has not been fully characterized in different cohorts of Ghanaians. This study sought to determine the characteristics of antibodies against EBA175RIII-V in asymptomatic adults and children living in two communities of varying P. Read More

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http://dx.doi.org/10.1186/s12865-018-0271-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245760PMC
November 2018
2 Reads

Lung-infiltrating T helper 17 cells as the major source of interleukin-17A production during pulmonary Cryptococcus neoformans infection.

BMC Immunol 2018 11 8;19(1):32. Epub 2018 Nov 8.

School of Bioscience, Taylor's University, Subang Jaya, Selangor, Malaysia.

Background: IL-17A has emerged as a key player in the pathologies of inflammation, autoimmune disease, and immunity to microbes since its discovery two decades ago. In this study, we aim to elucidate the activity of IL-17A in the protection against Cryptococcus neoformans, an opportunistic fungus that causes fatal meningoencephalitis among AIDS patients. For this purpose, we examined if C. Read More

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http://dx.doi.org/10.1186/s12865-018-0269-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225695PMC
November 2018
14 Reads
2.480 Impact Factor

Immune activation and regulatory T cells in Mycobacterium tuberculosis infected lymph nodes.

BMC Immunol 2018 11 8;19(1):33. Epub 2018 Nov 8.

Laboratory of Cellular Immunology, National Institute of Hygiene, 27, Avenue Ibn Batouta, PB 769, 11400, Rabat, Morocco.

Background: Lymph node tuberculosis (LNTB) is the most frequent extrapulmonary form of tuberculosis (TB). Studies of human tuberculosis at sites of disease are limited. LNTB provides a unique opportunity to compare local in situ and peripheral blood immune response in active Mycobacterium tuberculosis (Mtb) disease. Read More

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http://dx.doi.org/10.1186/s12865-018-0266-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225640PMC
November 2018
26 Reads

Altered endotoxin responsiveness in healthy children with Down syndrome.

BMC Immunol 2018 11 3;19(1):31. Epub 2018 Nov 3.

Paediatrics, Trinity College, the University of Dublin, Dublin, Ireland.

Background: Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined responses in CD11b and Toll like receptor 4 (TLR-4), which are important immune cell surface markers upregulated in response to Lipopolysaccharide (LPS) endotoxin, and the immunomodulator melatonin. Neutrophil and monocyte responses to LPS and melatonin in children with Down syndrome (DS) who were clinically stable were compared to age-matched controls. Read More

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https://www.researchgate.net/publication/7414581_Risk_of_Dea
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https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865
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http://dx.doi.org/10.1186/s12865-018-0270-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215672PMC
November 2018
21 Reads

Blood handling and leukocyte isolation methods impact the global transcriptome of immune cells.

BMC Immunol 2018 10 30;19(1):30. Epub 2018 Oct 30.

Department of Biological Engineering, Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Background: Transcriptional profiling with ultra-low input methods can yield valuable insights into disease, particularly when applied to the study of immune cells using RNA-sequencing. The advent of these methods has allowed for their use in profiling cells collected in clinical trials and other studies that involve the coordination of human-derived material. To date, few studies have sought to quantify what effects that collection and handling of this material can have on resulting data. Read More

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http://dx.doi.org/10.1186/s12865-018-0268-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208098PMC
October 2018
2 Reads

The excretory-secretory products of Echinococcus granulosus protoscoleces stimulated IL-10 production in B cells via TLR-2 signaling.

BMC Immunol 2018 10 24;19(1):29. Epub 2018 Oct 24.

Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, China.

Background: Excretory-secretory products released by Echinococcus granulosus protoscoleces (EgPSC-ESPs) are well-known to regulate T cell responses. However, their direct influence on the differentiation of B cell subsets remains largely elusive. This study investigated the effects of EgPSC-ESPs on the differentiation of IL-10-producing B cells (B10), and explored the possible role of Toll-like receptor 2 (TLR-2) signaling in this process. Read More

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http://dx.doi.org/10.1186/s12865-018-0267-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201587PMC
October 2018
3 Reads

Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway to induce interleukin-1β production.

BMC Immunol 2018 09 14;19(1):28. Epub 2018 Sep 14.

Zhongshan Hospital, Medical College of Xiamen University, Xiamen, Fujian Province, China.

Background: The involvement of inflammasome activation and macrophage polarization during the process of syphilis infection remains unknown. In this study, A series of experiments were performed using human macrophages to research the role of NLRP3 inflammasome regulation in interleukin (IL)-1β production and its influence on macrophage polarization triggered by T. pallidum. Read More

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http://dx.doi.org/10.1186/s12865-018-0265-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137923PMC
September 2018
6 Reads

Pharmacologically upregulated carcinoembryonic antigen-expression enhances the cytolytic activity of genetically-modified chimeric antigen receptor NK-92MI against colorectal cancer cells.

BMC Immunol 2018 08 3;19(1):27. Epub 2018 Aug 3.

Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, No.95, Wenchang Road, Shilin District, Taipei, Taiwan.

Background: The natural killer cell line, NK-92MI, is cytotoxic against various types of cancer. The aim of this study was to develop chimeric antigen receptor-modified (CAR) NK-92MI cells targeting carcinoembryonic antigen-expressing (CEA) tumours and increase killing efficacy by pharmacologically modifying CEA-expression.

Result: We generated anti-CEA-CAR NK-92MI cells by retroviral vector transduction. Read More

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http://dx.doi.org/10.1186/s12865-018-0262-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091054PMC
August 2018
8 Reads
2.481 Impact Factor

MiR-18a and miR-17 are positively correlated with circulating PD-1ICOS follicular helper T cells after hepatitis B vaccination in a chinese population.

BMC Immunol 2018 07 28;19(1):25. Epub 2018 Jul 28.

Department of Environmental and Occupational Health, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, 523808, China.

Background: While vaccination remains the most effective method to control hepatitis B virus (HBV) infection, 5-10% of recipients exhibit non-responsiveness to the HB vaccine. Immunological analysis of strong, weak or absent protective antibody responses to the HB vaccine should provide insights into the mechanisms that contribute to non-responsiveness.

Results: We investigated the potential involvement of follicular helper T (Tfh) cells in the immune response to HB vaccine, and associations between the miR-17-92 cluster and Tfh cells. Read More

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http://dx.doi.org/10.1186/s12865-018-0263-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064088PMC
July 2018
10 Reads

The differences in immunoadjuvant mechanisms of TLR3 and TLR4 agonists on the level of antigen-presenting cells during immunization with recombinant adenovirus vector.

BMC Immunol 2018 07 28;19(1):26. Epub 2018 Jul 28.

National Research Center Institute of Immunology, Federal Medical-Biological Agency of Russia, Moscow, Russia.

Background: Agonists of TLR3 and TLR4 are effective immunoadjuvants for different types of vaccines. The mechanisms of their immunostimulatory action differ significantly; these differences are particularly critical for immunization with non-replicating adenovirus vectors (rAds) based vaccines. Unlike traditional vaccines, rAd based vaccines are not designed to capture vaccine antigens from the external environment by antigen presenting cells (APCs), but rather they are targeted to the de novo synthesis of vaccine antigens in APCs transfected with rAd. Read More

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http://dx.doi.org/10.1186/s12865-018-0264-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064145PMC
July 2018
9 Reads

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity.

BMC Immunol 2018 07 11;19(1):24. Epub 2018 Jul 11.

Centre for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queen's University Belfast, Belfast, UK.

Background: Macrophages are tissue resident immune cells important for host defence and homeostasis. During diabetes, macrophages and other innate immune cells are known to have a pro-inflammatory phenotype, which is believed to contribute to the pathogenesis of various diabetic complications. However, diabetic patients are highly susceptible to bacterial infections, and often have impaired wound healing. Read More

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http://dx.doi.org/10.1186/s12865-018-0261-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042333PMC
July 2018
11 Reads
2.481 Impact Factor

Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats.

BMC Immunol 2018 07 9;19(1):23. Epub 2018 Jul 9.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997, Moscow, Russia.

Background: In many clinical cases of extensive liver resection (e.g. due to malignancy), the residual portion is too small to maintain the body homeostasis. Read More

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http://dx.doi.org/10.1186/s12865-018-0260-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038314PMC
July 2018
12 Reads

Analysis of differences between total IgG and sum of the IgG subclasses in children with suspected immunodeficiency - indication of determinants.

BMC Immunol 2018 06 27;19(1):22. Epub 2018 Jun 27.

Institute of Agricultural Engineering, Wroclaw University of Environmental and Life Sciences, J. Chełmońskiego 37/41, Wroclaw, 51-630, Poland.

Background: Deficits in disorders of humoral immunity associated with a deficit of antibodies are the most common primary immunodeficiency. Total IgG and IgG subclasses measurements are used to diagnose, differentiate and control in patients with primary and secondary immunodeficiencies.

Methods: The purpose of the study was to analyze the structure patients group according to difference between total IgG and sum of the IgG subclasses and to determine factors affecting the level of this difference. Read More

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http://dx.doi.org/10.1186/s12865-018-0259-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020421PMC
June 2018
34 Reads

Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice.

BMC Immunol 2018 06 25;19(1):20. Epub 2018 Jun 25.

Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, # 1095 Jiefang Avenue, Wuhan, 430030, People's Republic of China.

Background: Potassium channel tetramerisation domain containing 9 (KCTD9), a member of KCTD family with a DNA-like pentapeptide repeat domain, was found to be increased particularly in NK cells of patients with HBV-induced acute-on-chronic liver failure (HBV-ACLF) and experimental viral fulminant hepatitis. Knockdown of KCTD9 in immortalized NK cells inhibits cytokines production and cytotoxicity. As NK cell activation was shown to exacerbate liver damage in viral fulminant hepatitis, we propose that target inhibition of KCTD9 may prohibit NK cells activity and thus ameliorate liver damage in viral fulminant hepatitis. Read More

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http://dx.doi.org/10.1186/s12865-018-0256-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019787PMC
June 2018
12 Reads

Rapid loss of early antigen-presenting activity of lymph node dendritic cells against Ag85A protein following Mycobacterium bovis BCG infection.

BMC Immunol 2018 06 25;19(1):19. Epub 2018 Jun 25.

Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, MOA of China, Yangzhou University, Yangzhou, China.

Background: Control of Mycobacterium tuberculosis (Mtb) infection requires CD4 T-cell responses and major histocompatibility complex class II (MHC II) presentation of Mtb antigens (Ags). Dendritic cells (DCs) are the most potent of the Ag-presenting cells and are central to the initiation of T-cell immune responses. Much research has indicated that DCs play an important role in anti-mycobacterial immune responses at early infection time points, but the kinetics of Ag presentation by these cells during these events are incompletely understood. Read More

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http://dx.doi.org/10.1186/s12865-018-0258-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019797PMC
June 2018
13 Reads

MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis.

BMC Immunol 2018 06 26;19(1):21. Epub 2018 Jun 26.

Division of Biomedical Science, Research School of Biology, The Australian National University, Canberra, Australia.

Background: Splenic stroma overlaid with hematopoietic progenitors supports in vitro hematopoiesis with production of dendritic-like cells. Co-cultures of murine lineage-depleted bone marrow over the 5G3 stromal line produce two populations of cells, characterised as CD11bCD11cMHC-II dendritic-like 'L-DC', and CD11bCD11cMHC-II cells, resembling conventional dendritic cells (cDC). To date, the functional capacity of these two subsets has not been clearly distinguished. Read More

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http://dx.doi.org/10.1186/s12865-018-0255-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020213PMC
June 2018
3 Reads

A pilot and comparative study between pathological and serological levels of immunoglobulin and complement among three kinds of primary glomerulonephritis.

BMC Immunol 2018 06 20;19(1):18. Epub 2018 Jun 20.

Department of Nephrology, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Medical Institution Conducting Clinical Trials, Chinese PLA General Hospital, Beijing, China.

Background: Immunoglobulin A nephropathy (IgAN), membranous nephropathy (MN) and minimal-change disease (MCD) are three common types of glomerulonephritis in China. Pathological diagnosis based on renal biopsy is the criterion and the golden standard for diagnosing the sub-types of primary or secondary glomerulonephritis. Immunoglobulin and complements might be used in the differential diagnosis of glomerulonephritis without renal biopsies. Read More

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http://dx.doi.org/10.1186/s12865-018-0254-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011399PMC
June 2018
12 Reads
2.481 Impact Factor

The expression analysis of Fra-1 gene and IL-11 protein in Iranian patients with ulcerative colitis.

BMC Immunol 2018 06 18;19(1):17. Epub 2018 Jun 18.

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Background: Fra-1 (fosl1) belongs to the activator protein1 (AP-1) family inducing IL-11 expression in oxidative stress condition. IL-11 plays a pivotal role in protecting epithelial barriers integrity. In this study, we investigated the Fra-1 gene expression in the inflamed mucosa of patients with ulcerative colitis (UC) as well as its relation to IL-11 expression. Read More

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http://dx.doi.org/10.1186/s12865-018-0257-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006762PMC
June 2018
11 Reads
2.481 Impact Factor

Cancer immunoprevention: from mice to early clinical trials.

BMC Immunol 2018 06 15;19(1):16. Epub 2018 Jun 15.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Viale Filopanti 22, 40126, Bologna, Italy.

Cancer immunoprevention is based on the fact that a functioning immune system controls tumor onset and development in humans and animals, thus leading to the idea that the enhancement of immune responses in healthy individuals could effectively reduce cancer risk later in life. Successful primary immunoprevention of tumors caused by hepatitis B and papilloma viruses is already implemented at the population level with specific vaccines. The immunoprevention of human tumors unrelated to infectious agents is an outstanding challenge. Read More

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http://dx.doi.org/10.1186/s12865-018-0253-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003025PMC
June 2018
4 Reads

A qualitatively validated mathematical-computational model of the immune response to the yellow fever vaccine.

BMC Immunol 2018 05 25;19(1):15. Epub 2018 May 25.

Graduate Program in Computational Modeling, Federal University of Juiz de Fora, Juiz de Fora, 36036-900, Brazil.

Background: Although a safe and effective yellow fever vaccine was developed more than 80 years ago, several issues regarding its use remain unclear. For example, what is the minimum dose that can provide immunity against the disease? A useful tool that can help researchers answer this and other related questions is a computational simulator that implements a mathematical model describing the human immune response to vaccination against yellow fever.

Methods: This work uses a system of ten ordinary differential equations to represent a few important populations in the response process generated by the body after vaccination. Read More

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http://dx.doi.org/10.1186/s12865-018-0252-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970533PMC
May 2018
8 Reads

Therapeutic cancer vaccine: phase I clinical tolerance study of Hu-rhEGF-rP64k/Mont in patients with newly diagnosed advanced non-small cell lung cancer.

BMC Immunol 2018 04 16;19(1):14. Epub 2018 Apr 16.

Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.

Background: Hu-rhEGF-rP64k/Mont is a biotechnology product for the treatment of advanced non-small cell lung cancer (NSCLC). The vaccine induces a neutralizing antibody-mediated immune response, against the normal circulating self-protein antigen epidermal growth factor (EGF), which prevents its binding to and activation of the EGF receptor, inhibiting the transduction of the signals that drive cancer cell proliferation, survival and spread. This phase I study aimed to evaluate the safety and the immunological response of Hu-rhEGF-rP64k vaccine in NSCLC patients. Read More

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http://dx.doi.org/10.1186/s12865-018-0249-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902871PMC
April 2018
7 Reads

Neutrophils in primary gastric tumors are correlated with neutrophil infiltration in tumor-draining lymph nodes and the systemic inflammatory response.

BMC Immunol 2018 04 16;19(1):13. Epub 2018 Apr 16.

Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Tumor-Associated Neutrophils (TANs) may be able to induce lymphangiogenesis and angiogenesis, although the detailed roles of TANs remain unclear. The Neutrophil-Lymphocyte Ratio (NLR) is an inflammation-based prognostic factor for gastric cancer. This study aimed to investigate the distribution of CD15neutrophils in the primary tumor and Tumor-Draining Lymph Nodes (TDLNs), and to examine the association of TANs with the clinicopathological features (including NLR) of patients with gastric cancer. Read More

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http://dx.doi.org/10.1186/s12865-018-0251-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902874PMC
April 2018
6 Reads
2.480 Impact Factor

Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications.

BMC Immunol 2018 03 21;19(1):12. Epub 2018 Mar 21.

La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92130, USA.

Background: Type 1 diabetes (T1D) is thought to be an autoimmune disease driven by anti-islet antigen responses and mediated by T-cells. Recent published data suggests that T-cell reactivity to modified peptides, effectively neoantigens, may promote T1D. These findings have given more credence to the concept that T1D may not be solely an error of immune recognition but may be propagated by errors in protein processing or in modifications to endogenous peptides occurring as result of hyperglycemia, endoplasmic reticulum (ER) stress, or general beta cell dysfunction. Read More

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http://dx.doi.org/10.1186/s12865-018-0250-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863483PMC
March 2018
30 Reads

In silico prediction of cancer immunogens: current state of the art.

BMC Immunol 2018 03 15;19(1):11. Epub 2018 Mar 15.

School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.

Cancer kills 8 million annually worldwide. Although survival rates in prevalent cancers continue to increase, many cancers have no effective treatment, prompting the search for new and improved protocols. Immunotherapy is a new and exciting addition to the anti-cancer arsenal. Read More

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http://dx.doi.org/10.1186/s12865-018-0248-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856276PMC
March 2018
6 Reads

Utility of dominant epitopes derived from cell-wall protein LppZ for immunodiagnostic of pulmonary tuberculosis.

BMC Immunol 2018 03 1;19(1):10. Epub 2018 Mar 1.

Department of Cellular and Molecular Biology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, 101149, China.

Background: Serological antibodies tests for tuberculosis (TB) are widely used in developing countries. They appear to have some advantages- faster, simple and could be used for extrapulmonary TB. However, most of current commercial TB serological tests are failed to provide sufficient sensitivity and specificity. Read More

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http://dx.doi.org/10.1186/s12865-018-0243-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831716PMC
March 2018
10 Reads

Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised.

BMC Immunol 2018 02 17;19(1). Epub 2018 Feb 17.

Department of Clinical and Diagnostic Sciences, Biomedical Sciences, School of Health Professions, University of Alabama at Birmingham, 1716 9th Ave S, SHPB 472, Birmingham, 35294, AL, USA.

Background: The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells. In an ovalbumin (OVA)-driven allergic asthma mouse model, moderate aerobic exercise increases TREG cell function in a contact-dependent manner that leads to a significant reduction in chronic inflammation and restoration of lung function. However, the mechanism, whereby exercise increases TREG function, remains unknown and was the focus of these investigations. Read More

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https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865
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http://dx.doi.org/10.1186/s12865-018-0244-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816563PMC
February 2018
13 Reads

Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-γ.

BMC Immunol 2018 02 13;19(1). Epub 2018 Feb 13.

Division of Hematology, Department of Internal Medicine, School of Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, the Netherlands.

Background: Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk between NK cells and dendritic cells (DC) is considered a promising tool to potentiate cancer vaccines. We investigated to what extent direct sensing of viral and bacterial motifs by NK cells contributes to the response of inflammatory DC against the same pathogenic stimulus. Read More

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http://dx.doi.org/10.1186/s12865-018-0247-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810032PMC
February 2018
7 Reads

Establishment of malignantly transformed dendritic cell line SU3-ihDCTC induced by Glioma stem cells and study on its sensitivity to resveratrol.

BMC Immunol 2018 02 2;19(1). Epub 2018 Feb 2.

Department of neurosurgery, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medcine, Wan'sheng Road 118, Suzhou, 215006, China.

Background: As a factor contributing to the tumor cell drug resistance, tumor microenvironment (TME) is being paid increasingly attention. However, the drug resistance of malignantly transformed cells in TME has rarely been revealed. This paper is designed to investigate the sensitivity of malignantly transformed cell line (ihDCTC) induced by glioma stem cells (GSCs) in TME to chemotherapeutic drugs. Read More

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http://dx.doi.org/10.1186/s12865-018-0246-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796576PMC
February 2018
12 Reads

Down selecting adjuvanted vaccine formulations: a comparative method for harmonized evaluation.

BMC Immunol 2018 01 31;19(1). Epub 2018 Jan 31.

Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands.

Background: The need for rapid and accurate comparison of panels of adjuvanted vaccine formulations and subsequent rational down selection, presents several challenges for modern vaccine development. Here we describe a method which may enable vaccine and adjuvant developers to compare antigen/adjuvant combinations in a harmonized fashion. Three reference antigens: Plasmodium falciparum apical membrane antigen 1 (AMA1), hepatitis B virus surface antigen (HBsAg), and Mycobacterium tuberculosis antigen 85A (Ag85A), were selected as model antigens and were each formulated with three adjuvants: aluminium oxyhydroxide, squalene-in-water emulsion, and a liposome formulation mixed with the purified saponin fraction QS21. Read More

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http://dx.doi.org/10.1186/s12865-018-0245-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793412PMC
January 2018
10 Reads

Co-localization of lymphoid aggregates and lymphatic networks in nose- (NALT) and lacrimal duct-associated lymphoid tissue (LDALT) of mice.

BMC Immunol 2018 01 25;19(1). Epub 2018 Jan 25.

Institute for Anatomy and Cell Biology, University Medical Hospital Göttingen, Kreuzbergring 36, D-37075, Göttingen, Germany.

Background: The lymphatic vascular pattern in the head of mice has rarely been studied, due to problems of sectioning and immunostaining of complex bony structures. Therefore, the association of head lymphoid tissues with the lymphatics has remained unknown although the mouse is the most often used species in immunology.

Results: Here, we studied the association of nasal and nasolacrimal duct lymphatics with lymphoid aggregates in 14-day-old and 2-month-old mice. Read More

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https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865
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http://dx.doi.org/10.1186/s12865-018-0242-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784693PMC
January 2018
26 Reads

RNA gene profile variation in peripheral blood mononuclear cells from rhesus macaques immunized with Hib conjugate vaccine, Hib capsular polysaccharide and TT carrier protein.

BMC Immunol 2018 01 25;19(1). Epub 2018 Jan 25.

Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 935 Jiaoling Road, Kunming, Yunnan, 650118, China.

Background: The Haemophilus influenzae type b (Hib) conjugate vaccine has been widely used in children to prevent invasive Hib disease because of its strong immunogenicity and antibody response induction relative to the capsular polysaccharide (CPS) antigen. The data from vaccine studies suggest that the conjugate vaccine contains carrier proteins that enhance and/or regulate the antigen's immunogenicity, but the mechanism of this enhancement remains unclear.

Methods: To explore the immunological role of the conjugate vaccine, we compared the immune responses and gene profiles of rhesus macaques after immunization with CPS, carrier protein tetanus toxoid (TT) or conjugate vaccine. Read More

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http://dx.doi.org/10.1186/s12865-018-0240-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784715PMC
January 2018
14 Reads