Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised.
- Kari J Dugger,
- Taylor Chrisman,
- Sarah L Sayner,
- Parker Chastain,
- Kacie Watson,
- Robert Estes
BMC Immunol 2018 Feb 17;19(1). Epub 2018 Feb 17.
Department of Clinical and Diagnostic Sciences, Biomedical Sciences, School of Health Professions, University of Alabama at Birmingham, 1716 9th Ave S, SHPB 472, Birmingham, 35294, AL, USA.
Background: The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells. In an ovalbumin (OVA)-driven allergic asthma mouse model, moderate aerobic exercise increases TREG cell function in a contact-dependent manner that leads to a significant reduction in chronic inflammation and restoration of lung function. However, the mechanism, whereby exercise increases TREG function, remains unknown and was the focus of these investigations. Read More