1,977 results match your criteria BMC Gastroenterology[Journal]


Inflammatory bowel disease patient perceptions of diagnostic and monitoring tests and procedures.

BMC Gastroenterol 2019 Feb 13;19(1):30. Epub 2019 Feb 13.

Department of Medicine, Université de Montréal & Montreal Heart Institute, Montreal, H1T 1C8, Canada.

Background: Inflammatory Bowel Disease (IBD) with its high incidence and prevalence rates in Canada generates a heavy burden of tests and procedures. The purpose of this study is to gain a better understanding of the transfer of information from physician to patient, as well as the patient understanding and perceptions about the tests and procedures that are ordered to them in the context of IBD diagnosis and monitoring.

Methods: An online questionnaire was completed by 210 IBD patients in Canada. Read More

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http://dx.doi.org/10.1186/s12876-019-0946-8DOI Listing
February 2019

Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial.

BMC Gastroenterol 2019 Feb 12;19(1):29. Epub 2019 Feb 12.

Department of Medicine, National University of Ireland, University College Cork, Cork University Hospital, Wilton, T12 DC4A, Cork, Ireland.

Background: Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease.

Methods: A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Read More

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http://dx.doi.org/10.1186/s12876-019-0952-xDOI Listing
February 2019

A comparison of the diagnosis of gastroparesis in 4 h pediatric gastric emptying studies versus 2 h studies.

BMC Gastroenterol 2019 Feb 11;19(1):26. Epub 2019 Feb 11.

Division of Gastroenterolgy, Children's Mercy Kansas City, 2401 Gillham Rd, Kansas City, MO, 64108, USA.

Background: In adults, there is a consensus for standards to diagnose gastroparesis utilizing a gastric emptying study as the key diagnostic modality but there is no consensus for a standard in pediatrics. Additionally, some cost savings might be achieved if symptoms could be utilized to predict patients with gastroparesis. The aims of the current study were to confirm the sensitivity of a 4 h study in the pediatric population and to assess whether the severity of symptoms were predictive of delayed gastric emptying. Read More

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http://dx.doi.org/10.1186/s12876-019-0948-6DOI Listing
February 2019

Hepatic sonic hedgehog protein expression measured by computer assisted morphometry significantly correlates with features of non-alcoholic steatohepatitis.

BMC Gastroenterol 2019 Feb 11;19(1):27. Epub 2019 Feb 11.

Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Virginia, USA.

Background: Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnosis of NASH. This pilot study was designed to confirm that staining for SHH is useful in NASH diagnosis and determine whether quantification of staining by computer assisted morphometry (CAM) can be used to assess severity of ballooning degeneration. Read More

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http://dx.doi.org/10.1186/s12876-019-0951-yDOI Listing
February 2019

Plasma levels of TNF-α, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD).

BMC Gastroenterol 2019 Feb 11;19(1):28. Epub 2019 Feb 11.

University of South Florida, Division of Gastroenterology, Florida, USA.

An elevation of serum inflammatory biomarkers in achalasia patients compared with controls recently was demonstrated. It has not been determined whether the elevation of inflammatory cytokines is unique to achalasia or occurs with other diseases involving the esophagus. The primary aim of our study was to compare the differences in plasma immunological profiles (TNF- α receptor, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23) of patients with achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD). Read More

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http://dx.doi.org/10.1186/s12876-019-0937-9DOI Listing
February 2019

Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.

BMC Gastroenterol 2019 Feb 8;19(1):25. Epub 2019 Feb 8.

Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

Background: Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from marginal donors. The attenuation of ischemia-reperfusion injury (IRI) in such marginal donors is therefore crucial for reducing the possibility of the primary non-function of grafts and graft loss. Some reports have found that molecular-hydrogen showed antioxidant and anti-inflammatory effects in preventing IRI in some non-hepatic transplant models. Read More

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http://dx.doi.org/10.1186/s12876-019-0939-7DOI Listing
February 2019

Clinicopathologic characteristics of early gastric cancer according to specific intragastric location.

BMC Gastroenterol 2019 Feb 8;19(1):24. Epub 2019 Feb 8.

Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, South Korea.

Background: Although the incidence of early gastric cancer (EGC) continues to rise, there have been few studies on the intra-gastric distribution and locational characteristics of EGCs. In addition, there has been no attempt to visualize the intra-gastric distribution of EGCs using a merged tumor map.

Methods: We investigated the anatomic distribution of 644 cases of EGCs and analyzed the correlation between clinicopathologic findings and location by dividing areas of the stomach vertically and transversely. Read More

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http://dx.doi.org/10.1186/s12876-019-0949-5DOI Listing
February 2019

The frequency, clinical course, and health related quality of life in adults with Gilbert's syndrome: a longitudinal study.

BMC Gastroenterol 2019 Feb 4;19(1):22. Epub 2019 Feb 4.

Faculty of Medicine, Misr University for Science and Technology, Cairo, Egypt.

Background: Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, genetic profile and health related quality of life in Egyptian adults.

Methods: An initial cross-sectional study was conducted to assess the frequency of Gilbert syndrome among Egyptian adults. Read More

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http://dx.doi.org/10.1186/s12876-019-0931-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360704PMC
February 2019
2 Reads

Endoscopic injection sclerotherapy versus N-Butyl-2 Cyanoacrylate injection in the management of actively bleeding esophageal varices: a randomized controlled trial.

BMC Gastroenterol 2019 Feb 4;19(1):23. Epub 2019 Feb 4.

Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: The management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may necessitate an alternative therapy for this group of patients. Read More

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http://dx.doi.org/10.1186/s12876-019-0940-1DOI Listing
February 2019
2.365 Impact Factor

Alterations in ERBB2 and BRCA and microsatellite instability as new personalized treatment options in small bowel carcinoma.

BMC Gastroenterol 2019 Feb 4;19(1):21. Epub 2019 Feb 4.

Institute of Pathology, University of Cologne, Cologne, Germany.

Background: Carcinomas of the small bowel are rare tumors usually with dismal prognosis. Most recently, some potentially treatable molecular alterations were described. We emphasize the growing evidence of individualized treatment options in small bowel carcinoma. Read More

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http://dx.doi.org/10.1186/s12876-019-0942-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360678PMC
February 2019
1 Read

Elevated D-dimer is associated with increased 28-day mortality in acute-on-chronic liver failure in China: a retrospective study.

BMC Gastroenterol 2019 Jan 31;19(1):20. Epub 2019 Jan 31.

Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by profound disrupted coagulation and fibrinolysis. Fibrinolytic marker D-dimer is increased in critically ill patients with cirrhosis which is associated with poorer prognosis. We aim to determine the potential association of D-dimer with the 28-day mortality in ACLF patients. Read More

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http://dx.doi.org/10.1186/s12876-019-0941-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357416PMC
January 2019
1 Read

High-intensity interval training and moderate-intensity continuous training in adults with Crohn's disease: a pilot randomised controlled trial.

BMC Gastroenterol 2019 Jan 29;19(1):19. Epub 2019 Jan 29.

Centre for Psychology and Sports Science, University of Hertfordshire, Life and Medical Sciences, CP Snow Building, College Lane, Hatfield, AL10 9AB, UK.

Background: This study assessed the feasibility and acceptability of two common types of exercise training-high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)-in adults with Crohn's disease (CD).

Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Read More

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http://dx.doi.org/10.1186/s12876-019-0936-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352351PMC
January 2019

The incidence, etiologies, outcomes, and predictors of mortality of acute liver failure in Thailand: a population-base study.

BMC Gastroenterol 2019 Jan 28;19(1):18. Epub 2019 Jan 28.

Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London, UK.

Background: Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients with ALF.

Methods: We conducted a population-based study of ALF patients hospitalized between 2009 and 2013 from the Thai Nationwide Hospital Admission database, which comprises 76% of all admissions from 858 hospitals across 77 provinces in Thailand. Read More

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http://dx.doi.org/10.1186/s12876-019-0935-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348628PMC
January 2019
2 Reads

Helicobacter pylori vacA, cagA and iceA genotypes in dyspeptic patients from southwestern region, Saudi Arabia: distribution and association with clinical outcomes and histopathological changes.

BMC Gastroenterol 2019 Jan 25;19(1):16. Epub 2019 Jan 25.

Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.

Background: The aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitioners and researchers in the region for better management of infections caused by such bacteria.

Methods: Four hundred two gastric biopsy specimens were analyzed using histopathological examination and real time-PCR. Read More

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http://dx.doi.org/10.1186/s12876-019-0934-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346553PMC
January 2019
3 Reads

Capecitabine plus bevacizumab versus capecitabine in maintenance treatment for untreated characterised KRAS exon 2 wild-type metastatic colorectal cancer: a retrospective analysis in Chinese postmenopausal women.

BMC Gastroenterol 2019 Jan 25;19(1):17. Epub 2019 Jan 25.

Emergency Department, The First Affiliated Hospital, Sun Yat-sen University, Huangpu East Road No. 183, Huangpu District, Guangzhou, 510700, China.

Background: Capecitabine plus bevacizumab (CAP-B) maintenance treatment after 6 cycles of capecitabine, oxaliplatin, and bevacizumab (CAPOXB) has demonstrated clinical activity and failure to compromise quality of life in patients with metastatic colorectal cancer (MCC) in a previous phase 3 CAIRO3 study. The objective of this study is to evaluate the efficacy and safety of CAP-B versus CAP in maintenance treatment after 6-cycle CAPOXB induction therapy in Chinese postmenopausal women with untreated characterised KRAS exon 2 wild-type MCC.

Methods: During 2012-2016, prospectively maintained databases were reviewed to evaluate cohorts with untreated characterised KRAS exon 2 wild-type MCC and stable disease or better after 6-cycle CAPOXB induction treatment. Read More

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http://dx.doi.org/10.1186/s12876-018-0916-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346504PMC
January 2019
3 Reads
2.365 Impact Factor

Superior mesenteric artery syndrome coexists with Nutcracker syndrome in a female: a case report.

BMC Gastroenterol 2019 Jan 23;19(1):15. Epub 2019 Jan 23.

Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, People's Republic of China.

Background: Superior mesenteric artery (SMA) syndrome, also known as Wilkie's syndrome or Benign duodenal stasis, is a rare benign disease. It could threaten the life if the manifestation is severe and the treatment is inappropriate. In the patients with SMA syndrome, the third portion (transverse part) of the duodenum is compressed externally between the SMA and abdominal aorta (AA) leading to duodenal stasis and gastrointestinal obstruction. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0932-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343343PMC
January 2019
2 Reads

Helicobacter pylori infection associated with an increased risk of colorectal adenomatous polyps in the Chinese population.

BMC Gastroenterol 2019 Jan 21;19(1):14. Epub 2019 Jan 21.

Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

Background: Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. Read More

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http://dx.doi.org/10.1186/s12876-018-0918-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341657PMC
January 2019
1 Read

Predictive models of disease burden at diagnosis in persons with adult-onset ulcerative colitis using health administrative data.

BMC Gastroenterol 2019 Jan 21;19(1):13. Epub 2019 Jan 21.

University of Ottawa, IC/ES, Children's Hospital of Eastern Ontario (CHEO), CHEO Research Institute, Children's Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON, K1H 8L1, Canada.

Background: Health administrative data is increasingly used to conduct population-based health services research. A major limitation of these data for the study of inflammatory bowel diseases is the absence of detailed clinical information relating to disease burden. We used Ontario health administrative data to develop predictive models of disease burden at diagnosis in ulcerative colitis (UC) patients for future use in population-based studies of incident UC cohorts. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0924-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341567PMC
January 2019
4 Reads

Encapsulating peritoneal sclerosis in a patient after allogeneic hematopoietic stem cell transplantation: a case report.

BMC Gastroenterol 2019 Jan 21;19(1):12. Epub 2019 Jan 21.

Department of Hematology, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan.

Background: Encapsulating peritoneal sclerosis (EPS) is a chronic clinical syndrome of acute or subacute gastrointestinal obstruction seen mainly in patients undergoing peritoneal dialysis. Although there are a few reports on EPS developing in non-peritoneal dialysis patients, it has not been reported in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). Here, we report a case of EPS after a second HSCT. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0933-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341688PMC
January 2019
5 Reads

Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn's disease.

BMC Gastroenterol 2019 Jan 15;19(1):11. Epub 2019 Jan 15.

Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.

Background: Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn's disease based upon clinical, imaging and pathological findings, were later found to have MNGIE. The cases provide novel clinicopathological insight, for two further reasons: both sisters remain ambulant and in employment in their late 20s and 30s; diagnosis in one sister was made after a suspected azathioprine-precipitated acute illness. Read More

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http://dx.doi.org/10.1186/s12876-018-0925-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334462PMC
January 2019
5 Reads

Role of colonic microbiota in the pathogenesis of ulcerative colitis.

BMC Gastroenterol 2019 Jan 14;19(1):10. Epub 2019 Jan 14.

School of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China.

Background: Recent studies have found gut microbiota to be closely associated with onset and perpetuation of UC. Currently, studies about gut microbiota have mainly covered samples collected from the intestinal lumen. However, the luminal flora is only part of the gut microbiota. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0930-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332670PMC
January 2019
7 Reads

Infantile-onset inflammatory bowel disease in a patient with Hermansky-Pudlak syndrome: a case report.

BMC Gastroenterol 2019 Jan 11;19(1). Epub 2019 Jan 11.

Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.

Background: Hermansky-Pudlak syndrome (HPS) is a rare, genetically heterogeneous disorder that manifests oculocutaneous albinism together with bleeding diatheses that reflect a platelet storage pool deficiency. Ten genetic subtypes of this autosomal recessive condition have been described to date. Some patients with Hermansky-Pudlak syndrome type 1, 4, or 6 develop Crohn's-like inflammatory bowel disease at any age including early childhood, but most often in adolescence or young adulthood. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0929-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329123PMC
January 2019
10 Reads

Helicobacter pylori infections in Ethiopia; prevalence and associated factors: a systematic review and meta-analysis.

BMC Gastroenterol 2019 Jan 10;19(1). Epub 2019 Jan 10.

Department of Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debra Tabor, Ethiopia.

Background: Helicobacter pylori (H.pylori) infections are prevalent and recognized as major cause of gastrointestinal diseases in Ethiopia. However, Studies conducted on the prevalence, risk factors and other clinical forms of H. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0927-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327617PMC
January 2019
5 Reads
2.365 Impact Factor

Risk factors and long-term outcome of disease extent progression in Asian patients with ulcerative colitis: a retrospective cohort study.

BMC Gastroenterol 2019 Jan 10;19(1). Epub 2019 Jan 10.

Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.

Background: The incidence of Ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. The aim of this study was to identify risk factors predictive of extent progression in Asian patients with UC and to evaluate the clinical outcome by longitudinal follow-up.

Methods: We retrospectively analyzed 518 UC patients without ascending colon involvement at diagnosis who were regularly followed and underwent colonoscopy between 2003 and 2016 in an Asian tertiary referral center. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0928-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327558PMC
January 2019
8 Reads

Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer.

BMC Gastroenterol 2019 Jan 9;19(1). Epub 2019 Jan 9.

First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged, 6720, Hungary.

Background: The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed methods of sampling.

Methods: To compare prospectively the diagnostic yield of EUS-FNA samples obtained with slow-pull (SP) and with standard suction technique (SS).

Results: EUS-FNA sampling was diagnostic in 72 of 92 cases (78. Read More

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http://dx.doi.org/10.1186/s12876-018-0921-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327397PMC
January 2019
3 Reads

Preventive effect of ecabet sodium on low-dose aspirin-induced small intestinal mucosal injury: a randomized, double-blind, pilot study.

BMC Gastroenterol 2019 Jan 8;19(1). Epub 2019 Jan 8.

Second Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-Machi, Takatsuki, Osaka, 569-8686, Japan.

Background: We aimed to investigate how high-dose ecabet sodium affects low-dose aspirin-induced small intestinal mucosal injury in healthy volunteers.

Methods: Healthy volunteers were enrolled randomly into one of two groups with the following drug regimens for 2 weeks: group A, low-dose aspirin once per day and group B, low-dose aspirin and 4.0 g of ecabet sodium. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0923-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323690PMC
January 2019
4 Reads

The 1000IBD project: multi-omics data of 1000 inflammatory bowel disease patients; data release 1.

BMC Gastroenterol 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, PO Box 30.001, 9700RB, Groningen, the Netherlands.

Background: Inflammatory bowel disease (IBD) is a chronic complex disease of the gastrointestinal tract. Patients with IBD can experience a wide range of symptoms, but the pathophysiological mechanisms that cause these individual differences in clinical presentation remain largely unknown. In consequence, IBD is currently classified into subtypes using clinical characteristics. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0917-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325838PMC
January 2019
5 Reads

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.

BMC Gastroenterol 2019 Jan 7;19(1). Epub 2019 Jan 7.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background: Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In response to extracellular acidification, proton activation of GPR65 stimulates cAMP and Rho signalling pathways. Read More

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http://dx.doi.org/10.1186/s12876-018-0922-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323805PMC
January 2019
1 Read

Retrospective analysis of Clostridium difficile infection in patients with ulcerative colitis in a tertiary hospital in China.

BMC Gastroenterol 2019 Jan 7;19(1). Epub 2019 Jan 7.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Many reports have documented the increasing impact of Clostridium difficile infection (CDI) in patients with ulcerative colitis (UC). We conducted a retrospective study to determine the incidence, clinical characteristics, risk factors and prognosis of CDI in patients with UC.

Methods: We studied patients with UC, hospitalized between January 2010 and December 2015 in a tertiary hospital in China. Read More

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http://dx.doi.org/10.1186/s12876-018-0920-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323708PMC
January 2019
4 Reads

Cancer risk in microscopic colitis: a retrospective cohort study.

BMC Gastroenterol 2019 Jan 5;19(1). Epub 2019 Jan 5.

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, 02114, USA.

Background: The long-term natural history of microscopic colitis (MC) (collagenous colitis (CC), lymphocytic colitis (LC)), traditionally considered relapsing but non-progressive diseases, is poorly defined. Whether persistent histologic inflammation in such diseases is associated with an increased risk of colorectal neoplasia (CRN) or extracolonic cancers has not been robustly established.

Methods: This retrospective cohort included diagnosed with MC at a referral center. Read More

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http://dx.doi.org/10.1186/s12876-018-0926-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321729PMC
January 2019
2 Reads

Endoscopic and clinicopathological features of intramucosal, histologically mixed-type, low-grade, well-differentiated gastric tubular adenocarcinoma with the potential for late-onset lymph node metastasis.

BMC Gastroenterol 2018 Dec 27;18(1):189. Epub 2018 Dec 27.

Department of Pathology, Niigata Cancer Center Hospital, 2-15-3 Kawagishi-cho, Chuo-ku, Niigata, 951-8566, Japan.

Background: Intramucosal, histologically mixed-type, low-grade (LG), well-differentiated gastric tubular adenocarcinomas (tub1s; LG-tub1s) have larger mean diameters and exhibit a higher frequency of the gastric mucin phenotype (G-phenotype) than pure LG-tub1s. In proportion to their increases in diameter, G-phenotype differentiated-type early gastric cancer (EGC) tumours reportedly grow to eventually contain (an) undifferentiated-type component(s) and LG-tub1s, which are included in differentiated-type EGCs, reportedly exhibit changes in their glandular architectural and cytological atypia grades from LG to high-grade (HG) and can grow to contain a moderately differentiated tubular adenocarcinoma (tub2) component and undifferentiated components. Because they generally show a higher frequency of malignancy relative to tumours with a higher atypia grade and lower differentiation degree, it is suggested that, among mixed-type LG-tub1s, G-phenotype LG-tub1s containing an HG-tub2 component (LG-tub1s > HG-tub2) with undifferentiated components might lead to late-onset metastasis to lymph nodes even after a successful endoscopic submucosal dissection (ESD). Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0919-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307236PMC
December 2018
6 Reads

Lower expression of endogenous intestinal alkaline phosphatase may predict worse prognosis in patients with Crohn's disease.

BMC Gastroenterol 2018 Dec 17;18(1):188. Epub 2018 Dec 17.

Division of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.

Backgrounds: Intestinal alkaline phosphatase (IAP) plays important role in gut homeostasis. We aimed to evaluate the expression of endogenous IAP and to assess the clinical course according to the expression of endogenous IAP in patients with Crohn's disease (CD).

Methods: A total of 32 consecutive patients (14 males) with CD were included in the study. Read More

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http://dx.doi.org/10.1186/s12876-018-0904-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296121PMC
December 2018
3 Reads

Prognostic value of progesterone receptor in solid pseudopapillary neoplasm of the pancreas: evaluation of a pooled case series.

BMC Gastroenterol 2018 Dec 14;18(1):187. Epub 2018 Dec 14.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: The role of progesterone receptor (PR) has been reported in a series of pancreatic cysts. However, the relationship between PR and prognosis of solid pseudopapillary neoplasm of the pancreas (SPNP) has not been elucidated so far. The aim of our study was to evaluate the prognostic value of PR in SPNP. Read More

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http://dx.doi.org/10.1186/s12876-018-0914-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295102PMC
December 2018
1 Read

Diagnostic value of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma.

BMC Gastroenterol 2018 Dec 13;18(1):186. Epub 2018 Dec 13.

Department of Clinical Laboratory, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, 710061, People's Republic of China.

Background: To investigate the diagnostic performance of alpha-fetoprotein (AFP) and neutrophil-to-lymphocyte ratio (NLR) as well as their combinations with other markers.

Methods: Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), AFP and levels as well as the numbers of neutrophils and lymphocytes of all enrolled patients were collected. The NLR was calculated by dividing the number of neutrophils by the number of lymphocytes. Read More

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http://dx.doi.org/10.1186/s12876-018-0908-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293657PMC
December 2018
2 Reads
2.365 Impact Factor

Exclusive enteral nutrition with concomitant early thiopurine use was effective in maintaining steroid-free remission in a Southeast Asian cohort of children with Crohn's disease.

BMC Gastroenterol 2018 Dec 12;18(1):185. Epub 2018 Dec 12.

Gastroenterology Service, Department of Paediatric Medicine, KK Women's and Children's Hospital, KK Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Background: Exclusive enteral nutrition (EEN) is as effective as corticosteroids in inducing remission in children with Crohn's disease (CD). However, over 50% of these children relapse by 12 months of diagnosis. Thiopurines are commonly prescribed as maintenance therapy for CD, but evidence for its efficacy is controversial. Read More

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http://dx.doi.org/10.1186/s12876-018-0907-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292012PMC
December 2018
2 Reads
2.365 Impact Factor

Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer.

BMC Gastroenterol 2018 Dec 10;18(1):184. Epub 2018 Dec 10.

Faculty of Health Sciences, BIOGEN Research Group, Universidad de Santander, Avenida 4 10N-61, El Bosque, Cúcuta, Colombia.

Background: Gastric Cancer is highly prevalent and deadly worldwide. In Colombia, it is the most lethal form of cancer. Some single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes have been associated with an anti-inflammatory environment and a Th2 profile in detriment of the antitumor Th1 response. Read More

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http://dx.doi.org/10.1186/s12876-018-0913-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288868PMC
December 2018
1 Read

The diagnostic ability of SPECT/CT fusion imaging for gastrointestinal bleeding: a retrospective study.

BMC Gastroenterol 2018 Dec 10;18(1):183. Epub 2018 Dec 10.

Department of Radiology, Tokushima University Hospital, 2-50-1 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.

Background: Blood loss from the gastrointestinal tract can be an acute and life-threatening event. For the treatment of gastrointestinal bleeding, it is important to accurately detect gastrointestinal bleeding and to localize the sites of bleeding. The purpose of this study was to retrospectively assess the capabilities of SPECT/CT in the diagnosis of gastrointestinal bleeding by a comparison with planar imaging alone as well as planar and SPECT. Read More

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http://dx.doi.org/10.1186/s12876-018-0915-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288946PMC
December 2018
3 Reads

Risk factor for steatorrhea in pediatric chronic pancreatitis patients.

BMC Gastroenterol 2018 Dec 5;18(1):182. Epub 2018 Dec 5.

Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.

Background: Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. Read More

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http://dx.doi.org/10.1186/s12876-018-0902-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280450PMC
December 2018
2 Reads

Ultrasonic assessment of liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis.

BMC Gastroenterol 2018 Dec 5;18(1):181. Epub 2018 Dec 5.

Department of Ultrasound Diagnosis, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, Shaanxi Province, China.

Background: This study investigated the relationship between liver stiffness and carotid artery elasticity in patients with chronic viral hepatitis. We used an acoustic radiation force impulse (ARFI) technique to measure stiffness, and a radio frequency (RF) vascular quantitative ultrasound technique to measure changes in common carotid artery elasticity and vascular function.

Methods: Two-hundred seventeen patients with chronic viral hepatitis caused by either hepatitis B virus (HBV) or hepatitis C virus (HCV) were enrolled. Read More

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http://dx.doi.org/10.1186/s12876-018-0910-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280487PMC
December 2018
3 Reads

Characterization of intrahepatic cholangiocarcinoma after curative resection: outcome, prognostic factor, and recurrence.

BMC Gastroenterol 2018 Dec 4;18(1):180. Epub 2018 Dec 4.

Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, 5 Fu-Hsing Street, Kwei-Shan District, Taoyuan City, 33305, Taiwan.

Background: Intrahepatic cholangiocarcinoma (ICC) is a relatively rare subtype of cholangiocarcinoma. The study herein gathered experience of surgical treatment for ICC, and aimed to analyze the prognosis of patients who had received curative-intent liver resection.

Methods: A total of 216 patients who had undergone curative-intent liver resection for ICC between January 1977 and December 2014 was retrospectively reviewed. Read More

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http://dx.doi.org/10.1186/s12876-018-0912-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278092PMC
December 2018
2 Reads

Development and external validation of a prognostic nomogram for acute decompensation of chronic hepatitis B cirrhosis.

BMC Gastroenterol 2018 Dec 3;18(1):179. Epub 2018 Dec 3.

Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Background: Acute decompensation (AD) has been shown to be associated with a high mortality rate for cirrhosis patients. This study aimed to develop a prognostic nomogram to evaluating the individual prognosis for AD of cirrhosis in chronic hepatitis B (CHB).

Methods: The nomogram was developed using data from a retrospective study on 509 patients hospitalized for AD of CHB cirrhosis from October 2008 to February 2014 at the Beijing Ditan Hospital, Capital Medical University. Read More

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http://dx.doi.org/10.1186/s12876-018-0911-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276255PMC
December 2018
1 Read

Prevalence of and risk factors for fatty liver in the general population of Northern Italy: the Bagnacavallo Study.

BMC Gastroenterol 2018 Nov 28;18(1):177. Epub 2018 Nov 28.

Department of Internal Medicine, Ospedale di Faenza, AUSL Romagna, Faenza, Italy.

Background: The estimation of the burden of disease attributable to fatty liver requires studies performed in the general population.

Methods: The Bagnacavallo Study was performed between October 2005 and March 2009. All the citizens of Bagnacavallo (Ravenna, Italy) aged 30 to 60 years as of January 2005 were eligible. Read More

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http://dx.doi.org/10.1186/s12876-018-0906-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262973PMC
November 2018
3 Reads
2.365 Impact Factor

Stapleless laparoscopic left lateral sectionectomy for hepatocellular carcinoma: reappraisal of the Louisville statement by a young liver surgeon.

BMC Gastroenterol 2018 Nov 28;18(1):178. Epub 2018 Nov 28.

Department of Surgery, Linkou Chang Gung Memorial Hospital, No.5, Fuxing St, Guishan Dist, Taoyuan City, 33305, Taiwan, Republic of China.

Background: Laparoscopic liver resection has been regarded as the standard treatment for liver tumors located at the left lateral liver sector. However, few studies have reported the results of laparoscopic left lateral sectionectomy (LLS) for HCC, not to mention the feasibility of this emerging technique for the less experienced liver surgeons. The current study would reappraise the Louisville statement by examining the outcome of LLS performed by a young liver surgeon. Read More

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http://dx.doi.org/10.1186/s12876-018-0903-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264597PMC
November 2018
2 Reads
2.365 Impact Factor

Braun anastomosis lowers the incidence of delayed gastric emptying following pancreaticoduodenectomy: a meta-analysis.

BMC Gastroenterol 2018 Nov 26;18(1):176. Epub 2018 Nov 26.

Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, Xiamen, China.

Background: Delayed gastric emptying (DGE) is one of the most frequent complications following pancreaticoduodenectomy. This meta-analysis aimed to evaluate the impact of Braun enteroenterostomy on DGE following pancreaticoduodenectomy.

Methods: A systematic review of the literature was performed to identify relevant studies. Read More

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http://dx.doi.org/10.1186/s12876-018-0909-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258435PMC
November 2018
12 Reads

Neuroprotective effects of vitamin D on high fat diet- and palmitic acid-induced enteric neuronal loss in mice.

BMC Gastroenterol 2018 Nov 21;18(1):175. Epub 2018 Nov 21.

Unit of Neurogastroenterology, Department of Experimental Medical Science, Lund University, Sölvegatan 19, BMC B11, 22184, Lund, Sweden.

Background: The role of vitamin D in obesity and diabetes is debated. Obese and/or diabetic patients have elevated levels of free fatty acids, increased susceptibility to gastrointestinal symptoms and are suggested to have altered vitamin D balance. The enteric nervous system is pivotal in regulating gastrointestinal activity and high fat diet (HFD) has been shown to cause loss of enteric neurons in ileum and colon. Read More

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http://dx.doi.org/10.1186/s12876-018-0905-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249721PMC
November 2018
8 Reads

Clinical characteristics of hepatic Arterioportal shunts associated with hepatocellular carcinoma.

BMC Gastroenterol 2018 Nov 12;18(1):174. Epub 2018 Nov 12.

Department of Thoracic Oncology Surgery, Shandong Tumor Hospital Affiliated to Shandong University, No. 440, Jiyan Road, Jinan, 250117, China.

Background: Hepatic arterioportal shunt (A-P shunt) is defined as the direct blood flow established between hepatic artery and portal venous system; it is frequently observed in patients with hepatocellular carcinoma (HCC). Clinically, it is important to diagnose HCC associated A-P shunts, as it may impact the treatment strategy of the patients. In the present study, we described the imaging findings of the HCC associated A-P shunts and discussed the treatments strategy of such patients. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0899-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233279PMC
November 2018
8 Reads

CT Enterography score: a potential predictor for severity assessment of active ulcerative colitis.

BMC Gastroenterol 2018 Nov 9;18(1):173. Epub 2018 Nov 9.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China.

Background: Evaluate the possibility of CT enterography (CTE) score system as a predictor in assessing active ulcerative colitis (UC) severity.

Methods: Forty-six patients with active UC with CTE and colonoscopy were enrolled. Based on modified Mayo score, patients were divided into three groups: mild (n = 10), moderate (n = 17) and severe (n = 19). Read More

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http://dx.doi.org/10.1186/s12876-018-0890-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230286PMC
November 2018
13 Reads

Evaluating gut microbiota profiles from archived fecal samples.

BMC Gastroenterol 2018 Nov 8;18(1):171. Epub 2018 Nov 8.

Section for Bowel Cancer Screening, Cancer Registry of Norway, Oslo, Norway.

Background: Associations between colorectal cancer and microbiota have been identified. Archived fecal samples might be valuable sample sources for investigating causality in carcinogenesis and biomarkers discovery due to the potential of performing longitudinal studies. However, the quality, quantity and stability of the gut microbiota in these fecal samples must be assessed prior to such studies. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0896-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225565PMC
November 2018
7 Reads

Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study.

BMC Gastroenterol 2018 Nov 8;18(1):172. Epub 2018 Nov 8.

Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Chronic autoimmune atrophic gastritis (CAAG) is an autoimmune disease characterized by hypo/achlorhydria. A role of CAAG in the pathogenesis of nutritional deficiencies has been reported, therefore we hypothesized a possible association between CAAG and 25-OH-Vitamin D [25(OH)D] deficiency. Aim of the present study is to evaluate the prevalence of 25(OH)D deficiency in CAAG patients. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0901-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225568PMC
November 2018
9 Reads

One-day oral polyethylene glycol based cleanout is effective for pre-colonoscopy preparation in children.

BMC Gastroenterol 2018 Nov 7;18(1):170. Epub 2018 Nov 7.

University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.

Background: The adequacy of pre-procedure preparation is the principal determinant of the quality of colonoscopy in pediatric as in adult patients. There is a lack of consensus, among providers on a standard pre-procedure regimen. Professional society guidelines include the use of Polyethylene glycol (PEG). Read More

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http://dx.doi.org/10.1186/s12876-018-0895-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223084PMC
November 2018
1 Read