2,005 results match your criteria BMC Gastroenterology[Journal]


Vitamin K deficiency-induced hemorrhagic shock after thoracentesis: a case report.

BMC Gastroenterol 2019 Apr 18;19(1):58. Epub 2019 Apr 18.

Honjoudaiichi Hospital, 110, Iwabuchishita, Yurihonnjou, Akita, 015-8567, Japan.

Background: Vitamin K deficiency results in serious coagulation dysfunction, but hemorrhagic shock is rare. Herein, we describe a case of vitamin K deficiency and abnormality in the path of the intercostal artery, the combination of which led to hemorrhagic shock.

Case Presentation: An 83-year-old woman was hospitalized for suspected gallstones. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0978-0DOI Listing
April 2019
1 Read

A case of ectopic pancreas in the ileum presenting as obscure gastrointestinal bleeding and abdominal pain.

BMC Gastroenterol 2019 Apr 17;19(1):57. Epub 2019 Apr 17.

Clinic of Gastroenterology, Nephrourology and Surgery, Vilnius University, Santariskiu street 2, 08406, Vilnius, LT, Lithuania.

Background: Ectopic pancreas is an infrequent submucosal tumor in the gastrointestinal tract defined as a pancreatic tissue lacking vascular or anatomic continuity with the main body of the pancreas. Ectopic pancreas in the ileum is a rare and often an incidental finding. We report a case of ectopic pancreas in the ileum causing obscure gastrointestinal bleeding and episodes of abdominal pain. Read More

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http://dx.doi.org/10.1186/s12876-019-0971-7DOI Listing
April 2019
1 Read

Cases report: severe colonic bleeding in ulcerative colitis is refractory to selective transcatheter arterial embolization.

BMC Gastroenterol 2019 Apr 16;19(1):55. Epub 2019 Apr 16.

Servicio de Aparato Digestivo. Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, C/ Dr. Esquerdo 46, 28007, Madrid, Spain.

Background: Severe haemorrhage is an uncommon but life-threatening complication of ulcerative colitis (UC). Superselective transcatheter embolization has shown to be an effective and safe therapeutic modality in patients with lower gastrointestinal bleeding of various aetiologies; nevertheless, its role in UC-related acute bleeding is unknown.

Cases Presentation: Efficacy and safety of selective transcatheter arterial embolization in three consecutive UC patients diagnosed with massive haemorrhage admitted in a tertiary institution are reported. Read More

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http://dx.doi.org/10.1186/s12876-019-0970-8DOI Listing

Prevalence and long-term outcomes of non-alcoholic fatty liver disease among elderly individuals from the United States.

BMC Gastroenterol 2019 Apr 16;19(1):56. Epub 2019 Apr 16.

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Claude Moore Health Education and Research Building, 3300 Gallows Road, Falls Church, VA, 22042, USA.

Background: The prevalence and outcomes of non-alcoholic fatty liver disease (NAFLD) among elderly have not been well described. Our aim was to assess the prevalence, risk factors and mortality of NAFLD in individuals older than 60 years.

Methods: The data from the Third National Health and Nutrition Examination Survey with linked mortality files were utilized. Read More

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http://dx.doi.org/10.1186/s12876-019-0972-6DOI Listing
April 2019
1 Read

Serum HBV RNA quantification: useful for monitoring natural history of chronic hepatitis B infection.

BMC Gastroenterol 2019 Apr 16;19(1):53. Epub 2019 Apr 16.

Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.

Background: As an alternative biomarker of intrahepatic covalently closed circular DNA (cccDNA) transcriptional activity, hepatitis B virus (HBV) RNA may evolve during long-lasting virus-host interactions during chronic hepatitis B viral infection. The distribution pattern of serum HBV RNA levels in the natural course of chronic HBV infection remains unclear. The aim of this study was to evaluate the levels of HBV RNA during the natural course of CHB and the role in distinguishing the natural history of HBV infection. Read More

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http://dx.doi.org/10.1186/s12876-019-0966-4DOI Listing

Endoscopic transpapillary drainage in disconnected pancreatic duct syndrome after acute pancreatitis and trauma: long-term outcomes in 31 patients.

BMC Gastroenterol 2019 Apr 16;19(1):54. Epub 2019 Apr 16.

Department of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.

Background: Conventionally, disconnected pancreatic duct syndrome is treated surgically. Endoscopic management is associated with lesser morbidity and mortality than that observed with surgery and shows similar success rates. However, limited data are available in this context. Read More

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http://dx.doi.org/10.1186/s12876-019-0977-1DOI Listing
April 2019
1 Read

Comparison of the prevalence, severity, and risk factors for hepatic steatosis in HIV-infected and uninfected people.

BMC Gastroenterol 2019 Apr 15;19(1):52. Epub 2019 Apr 15.

Department of Medicine and Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Hepatic steatosis is prevalent in Western countries, but few studies have evaluated whether the frequency and severity of steatosis are greater in the setting of HIV infection. We compared the prevalence and severity of hepatic steatosis between HIV-infected (HIV+) and uninfected persons and identified factors associated with greater steatosis severity within both groups.

Methods: We performed a cross-sectional study among participants without cardiovascular disease who participated in a substudy of the Veterans Aging Cohort Study. Read More

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http://dx.doi.org/10.1186/s12876-019-0969-1DOI Listing
April 2019
1 Read

Diagnostic accuracy of controlled attenuation parameter (CAP) as a non-invasive test for steatosis in suspected non-alcoholic fatty liver disease: a systematic review and meta-analysis.

BMC Gastroenterol 2019 Apr 8;19(1):51. Epub 2019 Apr 8.

Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.

Background: Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis. Despite good diagnostic performance, clinical application of CAP is limited due to the influences of covariates. Here, a systematic review on the performance of CAP in the diagnosis and staging of hepatic steatosis in NAFLD patients was performed. Read More

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http://dx.doi.org/10.1186/s12876-019-0961-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454693PMC
April 2019
2 Reads

A retrospective clinical and microbial analysis of 32 patients with bilomas.

BMC Gastroenterol 2019 Apr 4;19(1):50. Epub 2019 Apr 4.

Klinikum rechts der Isar, Technische Universität München, Innere Medizin II, Ismaningerstrasse 22, 81675, Munich, Germany.

Background: Bilomas are defined collections of bile fluids mainly caused by iatrogenic injuries of the bile duct system. Owing to the infrequency of this disease, studies addressing bilomas are rare.

Methods: By using an endoscopic database, this retrospective study identified 32 patients with bilomas treated between 2004 to 2015, in order to analyse aetiology, clinical presentation, spectrum of pathogens, and resolution rate of bilomas. Read More

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http://dx.doi.org/10.1186/s12876-019-0968-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450004PMC
April 2019
1 Read

Case report of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE): a rare disease may contribute to endoscopy-capsule retention in the small intestine.

BMC Gastroenterol 2019 Apr 3;19(1):49. Epub 2019 Apr 3.

Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Ren-Ji Hospital, Shanghai Jiao-Tong University School of Medicine, 145 Middle Shandong Road, Shanghai, 200001, China.

Background: CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel.

Case Presentation: Here, we present a case of 43-year-old female patient suffered chronic abdominal pain for 20 years, and finally diagnosed with CMUSE. Capsule endoscopy was performed when general endoscopic investigation failed to find the lesion, but the capsule was stranded in the small intestine. Read More

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http://dx.doi.org/10.1186/s12876-019-0962-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448319PMC
April 2019
4 Reads

Hepatobiliary and pancreatic manifestations in inflammatory bowel diseases: a referral center study.

BMC Gastroenterol 2019 Apr 3;19(1):48. Epub 2019 Apr 3.

Department of Gastroenterology and Hepatology, Medical school and University of Ioannina, Ioannina, Greece.

Background: Hepatobiliary and pancreatic manifestations have been reported in patients with Crohn's disease or ulcerative colitis. Our aim was to describe the prevalence of hepatobiliary and pancreatic manifestations in inflammatory bowel disease and their association with the disease itself and the medications used.

Methods: Data were retrospectively extracted from the clinical records of patients followed up at our tertiary IBD referral Center. Read More

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http://dx.doi.org/10.1186/s12876-019-0967-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446300PMC
April 2019
2 Reads

Presenting symptoms in inflammatory bowel disease: descriptive analysis of a community-based inception cohort.

BMC Gastroenterol 2019 Apr 2;19(1):47. Epub 2019 Apr 2.

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: Few data are currently available on the initial presenting symptoms of patients with inflammatory bowel disease (IBD).

Methods: We evaluated the initial symptom presentation of patients with IBD in the Ocean State Crohn's and Colitis Area Registry (OSCCAR), a community-based inception cohort that enrolled Rhode Island IBD patients at time of diagnosis with longitudinal follow up. A 41-question symptom inventory was administered at time of enrollment to capture symptoms experienced during the 4 weeks preceding diagnosis of IBD. Read More

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http://dx.doi.org/10.1186/s12876-019-0963-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446285PMC
April 2019
3 Reads

Correction to: The 1000IBD project: multi-omics data of 1000 inflammatory bowel disease patients; data release 1.

BMC Gastroenterol 2019 03 27;19(1):44. Epub 2019 Mar 27.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, PO Box 30.001, 9700RB, Groningen, the Netherlands.

Following publication of the original article [1], the authors. Read More

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http://dx.doi.org/10.1186/s12876-019-0938-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436211PMC
March 2019
1 Read

Impact of primary colorectal Cancer location on the KRAS status and its prognostic value.

BMC Gastroenterol 2019 Mar 27;19(1):46. Epub 2019 Mar 27.

Department of Research, Affiliated Tumor Hospital of Guangxi Medical University, 71 Hedi Road, Nanning, 530021, China.

Background: Colorectal cancer (CRC) originating from the right-sided or left-sided colon is distinct clinicopathological entity. The KRAS status and its prognostic value in CRC remain controversial. This study aimed to investigate the association of KRAS status with clinicopathological features and prognostic value in CRC. Read More

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http://dx.doi.org/10.1186/s12876-019-0965-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437985PMC
March 2019
1 Read

Small bowel adenocarcinoma as a complication of celiac disease: clinical and diagnostic features.

BMC Gastroenterol 2019 Mar 27;19(1):45. Epub 2019 Mar 27.

Department of Medical Sciences, University of Ferrara, St. Anna Hospital, Via Aldo Moro, 8, 44124, Ferrara, Cona, Italy.

Background: Small bowel adenocarcinoma (SBA) is a rare neoplasm, which can occur in a sporadic form or can be associated with a number of predisposing conditions such as hereditary syndromes and immune-mediated intestinal disorders, e.g. celiac disease (CD). Read More

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http://dx.doi.org/10.1186/s12876-019-0964-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437995PMC
March 2019
1 Read

The role of Small Intestinal Bacterial Overgrowth (SIBO) in Non-alcoholic Fatty Liver Disease (NAFLD) patients evaluated using Controlled Attenuation Parameter (CAP) Transient Elastography (TE): a tertiary referral center experience.

BMC Gastroenterol 2019 Mar 20;19(1):43. Epub 2019 Mar 20.

Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia.

Background: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease, where it can progress to non-alcoholic steatohepatitis (NASH) and lead to liver cirrhosis or liver cancer. Small intestinal bacterial overgrowth (SIBO) has been hypothesized to play an important role in NAFLD development and progression, however, there is still conflicting data about this phenomenon. Transient Elastography (TE) examination using controlled attenuation parameter (CAP) has been validated for liver disease progression assessment in NAFLD. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s12876-019-0960-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427876PMC
March 2019
4 Reads

Gallbladder polyps - a follow-up study after 11 years.

BMC Gastroenterol 2019 Mar 18;19(1):42. Epub 2019 Mar 18.

Centre for Internal Medicine, Department of Internal Medicine I, Ulm University Hospital, Albert-Einstein-Allee 23, 89081, Ulm, Germany.

Background: The aim of our study was to investigate the prevalence and natural long-term progression of gallbladder polyps in a random sample of the general population.

Methods: Four hundred and thirteen subjects (190 women, 223 men; aged 29-75 years) were studied first in 2002 and again eleven years later in 2013. All subjects were interviewed using a standardised questionnaire, anthropometric data were recorded, and an abdominal ultrasound scan was carried out. Read More

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http://dx.doi.org/10.1186/s12876-019-0959-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423886PMC
March 2019
2 Reads

The FATZO mouse, a next generation model of type 2 diabetes, develops NAFLD and NASH when fed a Western diet supplemented with fructose.

BMC Gastroenterol 2019 Mar 18;19(1):41. Epub 2019 Mar 18.

Crown Bioscience Taicang Inc, Taicang, China.

Background: Metabolic disorders such as insulin resistance, obesity, and hyperglycemia are prominent risk factors for the development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH). Dietary rodent models employ high fat, high cholesterol, high fructose, methionine/choline deficient diets or combinations of these to induce NAFLD/NASH. The FATZO mice spontaneously develop the above metabolic disorders and type 2 diabetes (T2D) when fed with a normal chow diet. Read More

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http://dx.doi.org/10.1186/s12876-019-0958-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421686PMC
March 2019
4 Reads

Study protocol for a multicenter randomized controlled trial to compare the efficacy of end-ischemic dual hypothermic oxygenated machine perfusion with static cold storage in preventing non-anastomotic biliary strictures after transplantation of liver grafts donated after circulatory death: DHOPE-DCD trial.

BMC Gastroenterol 2019 Mar 12;19(1):40. Epub 2019 Mar 12.

Section Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands.

Background: The major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been proposed as an alternative strategy for organ preservation which reduces ischemia-reperfusion injury (IRI). Experimental studies have shown that dual hypothermic oxygenated machine perfusion (DHOPE) is associated with less IRI, improved hepatocellular function, and better preserved mitochondrial and endothelial function compared to conventional static cold storage (SCS). Read More

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http://dx.doi.org/10.1186/s12876-019-0956-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416838PMC
March 2019
2 Reads

The Association of obesity with vascular complications after liver transplantation.

BMC Gastroenterol 2019 Mar 7;19(1):39. Epub 2019 Mar 7.

Department of Organ Transplantation, First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan 2nd Road, Guangzhou, 510080, China.

Background: Because of the growing number of obese patients undergoing liver transplantation (LT), it is important to investigate the impact of obesity on post-transplant outcomes. Vascular complications are rare, but serious causes of morbidity and mortality after LT. It is not known if pre-transplant obesity is associated with an increased incidence of post-LT vascular complications. Read More

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http://dx.doi.org/10.1186/s12876-019-0954-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407261PMC
March 2019
4 Reads
2.365 Impact Factor

In-depth characterization of the Wnt-signaling/β-catenin pathway in an in vitro model of Barrett's sequence.

BMC Gastroenterol 2019 Mar 6;19(1):38. Epub 2019 Mar 6.

Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.

Background: An altered Wnt-signaling activation has been reported during Barrett's esophagus progression, but with rarely detected mutations in APC and β-catenin (CTNNB1) genes.

Methods: In this study, a robust in-depth expression pattern analysis of frizzled receptors, co-receptors, the Wnt-ligands Wnt3a and Wnt5a, the Wnt-signaling downstream targets Axin2, and CyclinD1, as well as the activation of the intracellular signaling kinases Akt and GSK3β was performed in an in vitro cell culture model of Barrett's esophagus. Representing the Barrett's sequence, we used normal esophageal squamous epithelium (EPC-1, EPC-2), metaplasia (CP-A) and dysplasia (CP-B) to esophageal adenocarcinoma (EAC) cell lines (OE33, OE19) and primary specimens of squamous epithelium, metaplasia and EAC. Read More

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http://dx.doi.org/10.1186/s12876-019-0957-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404335PMC
March 2019
1 Read
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Endoscopic injection sclerotherapy for pediatric bleeding esophageal varices complicated by gastric vein, main portal vein, splenic mesenteric junction, and splenic vein occlusion: a case report.

BMC Gastroenterol 2019 Feb 28;19(1):37. Epub 2019 Feb 28.

Liver Transplant Program, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Background: Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of the lack of an endoscopic banding ligation device for pediatric patients, EIS is usually performed for bleeding esophageal varices (EV) in infants with congenital biliary atresia.

Case Presentation: We present a case of a 15-month-old female infant with type I biliary atresia with jaundice (total serum bilirubin, 22. Read More

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http://dx.doi.org/10.1186/s12876-019-0955-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396477PMC
February 2019
2 Reads

Case report of patient with a Cronkhite-Canada syndrome: sustained remission after treatment with corticosteroids and mesalazine.

BMC Gastroenterol 2019 Feb 27;19(1):36. Epub 2019 Feb 27.

Department of Gastroenterology and Hepatology, University Hospital of Cologne, D-50937, Cologne, Germany.

Background: Cronkhite-Canada syndrome is a rare disease of unknown etiology and the optimal treatment for this syndrome is unknown.

Case Presentation: We present the case of a man who at the age of 66.0 years was diagnosed with Cronkhite-Canada syndrome (CCS). Read More

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http://dx.doi.org/10.1186/s12876-019-0944-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391814PMC
February 2019
8 Reads

The clinical value of ERCP-guided cholangiopancreatoscopy using a single-operator system.

BMC Gastroenterol 2019 Feb 26;19(1):35. Epub 2019 Feb 26.

Division of Surgery, CLINTEC, Karolinska Institutet, Center for Digestive Diseases, Karolinska University Hospital, Huddinge, 114 86, Stockholm, Sweden.

Background: Single-operator, per-oral cholangiopancreatoscopy (SOPCP) enables direct biliopancreatic ductal visualization, targeted tissue sampling, and therapeutic intervention. At Karolinska University Hospital, SOPCP was introduced early and has since been extensively utilized according to a standardized protocol. We analysed the clinical value of SOPCP in the diagnosis and treatment of biliopancreatic diseases in a single high volume center. Read More

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http://dx.doi.org/10.1186/s12876-019-0953-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390318PMC
February 2019

The endoscopic ultrasound probe findings in prediction of esophageal variceal recurrence after endoscopic variceal eradication therapies in cirrhotic patients: a cohort prospective study.

BMC Gastroenterol 2019 Feb 19;19(1):32. Epub 2019 Feb 19.

Department of Gastroenterology and Hepatology, Beijing You An Hospital affiliated to the Capital Medical University, 8 Xi Tou Tiao, Youanmen wai, Beijing, 100069, China.

Background: The recurrence of esophageal varices remains high in patients with hepatic portal hypertension after the endoscopic esophageal variceal eradication therapies, including endoscopic variceal band ligation (EVL), injection sclerotherapy (EIS) or EVL plus EIS. The aim of this study was to evaluate the endoscopic ultrasound probe examinations (EUP) findings in the prediction of recurrence following esophageal variceal eradication in a prospective cohort.

Methods: A total of 206 cirrhotic portal hypertension patients with esophageal variceal eradication, who underwent endoscopic variceal therapy (EVL or EIS or EVL plus EIS) were initially enrolled. Read More

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http://dx.doi.org/10.1186/s12876-019-0943-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380022PMC
February 2019
6 Reads
2.365 Impact Factor

What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study.

BMC Gastroenterol 2019 Feb 19;19(1):33. Epub 2019 Feb 19.

Department of Family Medicine, Changhua Christian Hospital, No. 135, St. Nan-Xiao, Changhua City, 500, Taiwan.

Background: The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). This study aimed to evaluate the correlation between RE and MetS and its components. Read More

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http://dx.doi.org/10.1186/s12876-019-0950-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381695PMC
February 2019
4 Reads
2.365 Impact Factor

Association between digestive symptoms and sleep disturbance: a cross-sectional community-based study.

BMC Gastroenterol 2019 Feb 19;19(1):34. Epub 2019 Feb 19.

Future Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 1672, Republic of Korea.

Background: This study was conducted to analyze the association between digestive symptoms and sleep disturbance, and to determine if any digestive symptoms are related to sleep disturbance.

Methods: This was a cross-sectional study of 5792 subjects surveyed in a community-based cohort. Subjects provided information regarding the quality of sleep as assessed by the Pittsburgh Sleep Quality Index (PSQI), as well as digestive symptoms as assessed by the Gastrointestinal Symptom Rating Scale (GSRS). Read More

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http://dx.doi.org/10.1186/s12876-019-0945-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381712PMC
February 2019
6 Reads

Autoantibody detection is not recommended for chronic pancreatitis: a cross-sectional Study of 557 patients.

BMC Gastroenterol 2019 Feb 14;19(1):31. Epub 2019 Feb 14.

Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.

Background: Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-AIP CP or not was unknown.

Methods: Hospitalized patients with non-AIP CP from January 2010 to October 2016 were detected for 22 autoantibodies at the time of hospital admission. Read More

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http://dx.doi.org/10.1186/s12876-019-0947-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376735PMC
February 2019
7 Reads

Inflammatory bowel disease patient perceptions of diagnostic and monitoring tests and procedures.

BMC Gastroenterol 2019 Feb 13;19(1):30. Epub 2019 Feb 13.

Department of Medicine, Université de Montréal & Montreal Heart Institute, Montreal, H1T 1C8, Canada.

Background: Inflammatory Bowel Disease (IBD) with its high incidence and prevalence rates in Canada generates a heavy burden of tests and procedures. The purpose of this study is to gain a better understanding of the transfer of information from physician to patient, as well as the patient understanding and perceptions about the tests and procedures that are ordered to them in the context of IBD diagnosis and monitoring.

Methods: An online questionnaire was completed by 210 IBD patients in Canada. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s12876-019-0946-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374885PMC
February 2019
3 Reads

Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial.

BMC Gastroenterol 2019 Feb 12;19(1):29. Epub 2019 Feb 12.

Department of Medicine, National University of Ireland, University College Cork, Cork University Hospital, Wilton, T12 DC4A, Cork, Ireland.

Background: Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease.

Methods: A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Read More

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http://dx.doi.org/10.1186/s12876-019-0952-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373036PMC
February 2019
3 Reads

A comparison of the diagnosis of gastroparesis in 4 h pediatric gastric emptying studies versus 2 h studies.

BMC Gastroenterol 2019 Feb 11;19(1):26. Epub 2019 Feb 11.

Division of Gastroenterolgy, Children's Mercy Kansas City, 2401 Gillham Rd, Kansas City, MO, 64108, USA.

Background: In adults, there is a consensus for standards to diagnose gastroparesis utilizing a gastric emptying study as the key diagnostic modality but there is no consensus for a standard in pediatrics. Additionally, some cost savings might be achieved if symptoms could be utilized to predict patients with gastroparesis. The aims of the current study were to confirm the sensitivity of a 4 h study in the pediatric population and to assess whether the severity of symptoms were predictive of delayed gastric emptying. Read More

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http://dx.doi.org/10.1186/s12876-019-0948-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371451PMC
February 2019
1 Read

Hepatic sonic hedgehog protein expression measured by computer assisted morphometry significantly correlates with features of non-alcoholic steatohepatitis.

BMC Gastroenterol 2019 Feb 11;19(1):27. Epub 2019 Feb 11.

Center for Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Virginia, USA.

Background: Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnosis of NASH. This pilot study was designed to confirm that staining for SHH is useful in NASH diagnosis and determine whether quantification of staining by computer assisted morphometry (CAM) can be used to assess severity of ballooning degeneration. Read More

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http://dx.doi.org/10.1186/s12876-019-0951-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371537PMC
February 2019
2 Reads

Plasma levels of TNF-α, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD).

BMC Gastroenterol 2019 Feb 11;19(1):28. Epub 2019 Feb 11.

University of South Florida, Division of Gastroenterology, Florida, USA.

An elevation of serum inflammatory biomarkers in achalasia patients compared with controls recently was demonstrated. It has not been determined whether the elevation of inflammatory cytokines is unique to achalasia or occurs with other diseases involving the esophagus. The primary aim of our study was to compare the differences in plasma immunological profiles (TNF- α receptor, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23) of patients with achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD). Read More

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http://dx.doi.org/10.1186/s12876-019-0937-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371504PMC
February 2019
2 Reads

Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.

BMC Gastroenterol 2019 Feb 8;19(1):25. Epub 2019 Feb 8.

Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

Background: Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from marginal donors. The attenuation of ischemia-reperfusion injury (IRI) in such marginal donors is therefore crucial for reducing the possibility of the primary non-function of grafts and graft loss. Some reports have found that molecular-hydrogen showed antioxidant and anti-inflammatory effects in preventing IRI in some non-hepatic transplant models. Read More

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http://dx.doi.org/10.1186/s12876-019-0939-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368804PMC
February 2019
7 Reads

Clinicopathologic characteristics of early gastric cancer according to specific intragastric location.

BMC Gastroenterol 2019 Feb 8;19(1):24. Epub 2019 Feb 8.

Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, South Korea.

Background: Although the incidence of early gastric cancer (EGC) continues to rise, there have been few studies on the intra-gastric distribution and locational characteristics of EGCs. In addition, there has been no attempt to visualize the intra-gastric distribution of EGCs using a merged tumor map.

Methods: We investigated the anatomic distribution of 644 cases of EGCs and analyzed the correlation between clinicopathologic findings and location by dividing areas of the stomach vertically and transversely. Read More

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http://dx.doi.org/10.1186/s12876-019-0949-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368692PMC
February 2019

The frequency, clinical course, and health related quality of life in adults with Gilbert's syndrome: a longitudinal study.

BMC Gastroenterol 2019 Feb 4;19(1):22. Epub 2019 Feb 4.

Faculty of Medicine, Misr University for Science and Technology, Cairo, Egypt.

Background: Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, genetic profile and health related quality of life in Egyptian adults.

Methods: An initial cross-sectional study was conducted to assess the frequency of Gilbert syndrome among Egyptian adults. Read More

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http://dx.doi.org/10.1186/s12876-019-0931-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360704PMC
February 2019
3 Reads

Endoscopic injection sclerotherapy versus N-Butyl-2 Cyanoacrylate injection in the management of actively bleeding esophageal varices: a randomized controlled trial.

BMC Gastroenterol 2019 Feb 4;19(1):23. Epub 2019 Feb 4.

Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: The management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may necessitate an alternative therapy for this group of patients. Read More

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http://dx.doi.org/10.1186/s12876-019-0940-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362581PMC
February 2019
2 Reads
2.365 Impact Factor

Alterations in ERBB2 and BRCA and microsatellite instability as new personalized treatment options in small bowel carcinoma.

BMC Gastroenterol 2019 Feb 4;19(1):21. Epub 2019 Feb 4.

Institute of Pathology, University of Cologne, Cologne, Germany.

Background: Carcinomas of the small bowel are rare tumors usually with dismal prognosis. Most recently, some potentially treatable molecular alterations were described. We emphasize the growing evidence of individualized treatment options in small bowel carcinoma. Read More

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http://dx.doi.org/10.1186/s12876-019-0942-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360678PMC
February 2019
5 Reads

Elevated D-dimer is associated with increased 28-day mortality in acute-on-chronic liver failure in China: a retrospective study.

BMC Gastroenterol 2019 Jan 31;19(1):20. Epub 2019 Jan 31.

Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by profound disrupted coagulation and fibrinolysis. Fibrinolytic marker D-dimer is increased in critically ill patients with cirrhosis which is associated with poorer prognosis. We aim to determine the potential association of D-dimer with the 28-day mortality in ACLF patients. Read More

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http://dx.doi.org/10.1186/s12876-019-0941-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357416PMC
January 2019
3 Reads

High-intensity interval training and moderate-intensity continuous training in adults with Crohn's disease: a pilot randomised controlled trial.

BMC Gastroenterol 2019 Jan 29;19(1):19. Epub 2019 Jan 29.

Centre for Psychology and Sports Science, University of Hertfordshire, Life and Medical Sciences, CP Snow Building, College Lane, Hatfield, AL10 9AB, UK.

Background: This study assessed the feasibility and acceptability of two common types of exercise training-high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)-in adults with Crohn's disease (CD).

Methods: In this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Read More

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http://dx.doi.org/10.1186/s12876-019-0936-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352351PMC
January 2019
18 Reads

The incidence, etiologies, outcomes, and predictors of mortality of acute liver failure in Thailand: a population-base study.

BMC Gastroenterol 2019 Jan 28;19(1):18. Epub 2019 Jan 28.

Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London, UK.

Background: Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients with ALF.

Methods: We conducted a population-based study of ALF patients hospitalized between 2009 and 2013 from the Thai Nationwide Hospital Admission database, which comprises 76% of all admissions from 858 hospitals across 77 provinces in Thailand. Read More

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http://dx.doi.org/10.1186/s12876-019-0935-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348628PMC
January 2019
12 Reads
2.365 Impact Factor

Helicobacter pylori vacA, cagA and iceA genotypes in dyspeptic patients from southwestern region, Saudi Arabia: distribution and association with clinical outcomes and histopathological changes.

BMC Gastroenterol 2019 Jan 25;19(1):16. Epub 2019 Jan 25.

Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.

Background: The aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitioners and researchers in the region for better management of infections caused by such bacteria.

Methods: Four hundred two gastric biopsy specimens were analyzed using histopathological examination and real time-PCR. Read More

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http://dx.doi.org/10.1186/s12876-019-0934-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346553PMC
January 2019
4 Reads

Capecitabine plus bevacizumab versus capecitabine in maintenance treatment for untreated characterised KRAS exon 2 wild-type metastatic colorectal cancer: a retrospective analysis in Chinese postmenopausal women.

BMC Gastroenterol 2019 Jan 25;19(1):17. Epub 2019 Jan 25.

Emergency Department, The First Affiliated Hospital, Sun Yat-sen University, Huangpu East Road No. 183, Huangpu District, Guangzhou, 510700, China.

Background: Capecitabine plus bevacizumab (CAP-B) maintenance treatment after 6 cycles of capecitabine, oxaliplatin, and bevacizumab (CAPOXB) has demonstrated clinical activity and failure to compromise quality of life in patients with metastatic colorectal cancer (MCC) in a previous phase 3 CAIRO3 study. The objective of this study is to evaluate the efficacy and safety of CAP-B versus CAP in maintenance treatment after 6-cycle CAPOXB induction therapy in Chinese postmenopausal women with untreated characterised KRAS exon 2 wild-type MCC.

Methods: During 2012-2016, prospectively maintained databases were reviewed to evaluate cohorts with untreated characterised KRAS exon 2 wild-type MCC and stable disease or better after 6-cycle CAPOXB induction treatment. Read More

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http://dx.doi.org/10.1186/s12876-018-0916-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346504PMC
January 2019
14 Reads
2.365 Impact Factor

Superior mesenteric artery syndrome coexists with Nutcracker syndrome in a female: a case report.

BMC Gastroenterol 2019 Jan 23;19(1):15. Epub 2019 Jan 23.

Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, People's Republic of China.

Background: Superior mesenteric artery (SMA) syndrome, also known as Wilkie's syndrome or Benign duodenal stasis, is a rare benign disease. It could threaten the life if the manifestation is severe and the treatment is inappropriate. In the patients with SMA syndrome, the third portion (transverse part) of the duodenum is compressed externally between the SMA and abdominal aorta (AA) leading to duodenal stasis and gastrointestinal obstruction. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0932-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343343PMC
January 2019
9 Reads

Helicobacter pylori infection associated with an increased risk of colorectal adenomatous polyps in the Chinese population.

BMC Gastroenterol 2019 Jan 21;19(1):14. Epub 2019 Jan 21.

Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.

Background: Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. Read More

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http://dx.doi.org/10.1186/s12876-018-0918-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341657PMC
January 2019
2 Reads

Predictive models of disease burden at diagnosis in persons with adult-onset ulcerative colitis using health administrative data.

BMC Gastroenterol 2019 Jan 21;19(1):13. Epub 2019 Jan 21.

University of Ottawa, IC/ES, Children's Hospital of Eastern Ontario (CHEO), CHEO Research Institute, Children's Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON, K1H 8L1, Canada.

Background: Health administrative data is increasingly used to conduct population-based health services research. A major limitation of these data for the study of inflammatory bowel diseases is the absence of detailed clinical information relating to disease burden. We used Ontario health administrative data to develop predictive models of disease burden at diagnosis in ulcerative colitis (UC) patients for future use in population-based studies of incident UC cohorts. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0924-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341567PMC
January 2019
9 Reads

Encapsulating peritoneal sclerosis in a patient after allogeneic hematopoietic stem cell transplantation: a case report.

BMC Gastroenterol 2019 Jan 21;19(1):12. Epub 2019 Jan 21.

Department of Hematology, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan.

Background: Encapsulating peritoneal sclerosis (EPS) is a chronic clinical syndrome of acute or subacute gastrointestinal obstruction seen mainly in patients undergoing peritoneal dialysis. Although there are a few reports on EPS developing in non-peritoneal dialysis patients, it has not been reported in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). Here, we report a case of EPS after a second HSCT. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0933-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341688PMC
January 2019
9 Reads

Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn's disease.

BMC Gastroenterol 2019 Jan 15;19(1):11. Epub 2019 Jan 15.

Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.

Background: Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn's disease based upon clinical, imaging and pathological findings, were later found to have MNGIE. The cases provide novel clinicopathological insight, for two further reasons: both sisters remain ambulant and in employment in their late 20s and 30s; diagnosis in one sister was made after a suspected azathioprine-precipitated acute illness. Read More

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http://dx.doi.org/10.1186/s12876-018-0925-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334462PMC
January 2019
9 Reads
2.365 Impact Factor

Role of colonic microbiota in the pathogenesis of ulcerative colitis.

BMC Gastroenterol 2019 Jan 14;19(1):10. Epub 2019 Jan 14.

School of Pharmacy, Minzu University of China, 27 South Street, Zhongguancun, Beijing, 100081, China.

Background: Recent studies have found gut microbiota to be closely associated with onset and perpetuation of UC. Currently, studies about gut microbiota have mainly covered samples collected from the intestinal lumen. However, the luminal flora is only part of the gut microbiota. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0930-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332670PMC
January 2019
11 Reads

Infantile-onset inflammatory bowel disease in a patient with Hermansky-Pudlak syndrome: a case report.

BMC Gastroenterol 2019 Jan 11;19(1). Epub 2019 Jan 11.

Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.

Background: Hermansky-Pudlak syndrome (HPS) is a rare, genetically heterogeneous disorder that manifests oculocutaneous albinism together with bleeding diatheses that reflect a platelet storage pool deficiency. Ten genetic subtypes of this autosomal recessive condition have been described to date. Some patients with Hermansky-Pudlak syndrome type 1, 4, or 6 develop Crohn's-like inflammatory bowel disease at any age including early childhood, but most often in adolescence or young adulthood. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-019-0929-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329123PMC
January 2019
15 Reads