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    HPV positive, wild type TP53, and p16 overexpression correlate with the absence of residual tumors after chemoradiotherapy in anal squamous cell carcinoma.
    BMC Gastroenterol 2018 Feb 21;18(1):30. Epub 2018 Feb 21.
    Hospital Ophir Loyola, Belém, Pará, 66060-281, Brazil.
    Background: Anal residual tumors are consensually identified within six months of chemoradiotherapy and represent a persistent lesion that may have prognostic value for overall survival. The aim of this study was to evaluate the association of HPV and HIV status, p16 expression level and TP53 mutations with the absence of residual tumors (local response) in Squamous Cell Carcinoma (SCC) of the anal canal after chemoradiotherapy.

    Methods: We performed a study on 78 patients with SCC of the anal canal who submitted to chemoradiotherapy and were followed for a six-month period to identify the absence or presence of residual tumors. Read More

    Evaluation of risk factors for perforated peptic ulcer.
    BMC Gastroenterol 2018 Feb 15;18(1):28. Epub 2018 Feb 15.
    Division of General Internal Medicine, Department of Medicine, St. Luke's International Hospital, Tokyo, Japan.
    Background: The aim of this study was to evaluate the prediction factors for perforated peptic ulcer (PPU).

    Methods: At St. Luke's International Hospital in Tokyo, Japan, a case control study was performed between August 2004 and March 2016. Read More

    Unexplained chronic liver disease in Ethiopia: a cross-sectional study.
    BMC Gastroenterol 2018 Feb 13;18(1):27. Epub 2018 Feb 13.
    Regional Centre for Imported and Tropical Diseases, Oslo University Hospital Ullevål, Oslo, Norway.
    Background: Hepatitis B virus (HBV) infection is assumed to be the major cause of chronic liver disease (CLD) in sub-Saharan Africa. The contribution of other aetiological causes of CLD is less well documented and hence opportunities to modulate other potential risk factors are being lost. The aims of this study were to explore the aetiological spectrum of CLD in eastern Ethiopia and to identify plausible underlying risk factors for its development. Read More

    Expression profiling and intracellular localization studies of the novel Proline-, Histidine-, and Glycine-rich protein 1 suggest an essential role in gastro-intestinal epithelium and a potential clinical application in colorectal cancer diagnostics.
    BMC Gastroenterol 2018 Feb 7;18(1):26. Epub 2018 Feb 7.
    Department of Hematology and Oncology, Stavanger University Hospital, 4068, Stavanger, Norway.
    Background: The primary function of the intestines is the absorption of water and nutrients. Although our knowledge about these processes on the cellular level is extensive, a number of important intracellular elements remain unknown. Here, we characterize the novel proline-, histidine-, glycine-rich 1 (PHGR1) mRNA and protein on the molecular level and propose a functional role of the PHGR1 protein in the intestinal and gastric epithelium. Read More

    Symptoms and diagnostic criteria of acquired Megacolon - a systematic literature review.
    BMC Gastroenterol 2018 Jan 31;18(1):25. Epub 2018 Jan 31.
    Cairns Clinical School, College of Medicine and Dentistry, James Cook University, 451 Draper Street, Cairns, QLD, 4870, Australia.
    Background: Acquired Megacolon (AMC) is a condition involving persistent dilatation and lengthening of the colon in the absence of organic disease. Diagnosis depends on subjective radiological, endoscopic or surgical findings in the context of a suggestive clinical presentation. This review sets out to investigate diagnostic criteria of AMC. Read More

    APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism.
    BMC Gastroenterol 2018 Jan 30;18(1):24. Epub 2018 Jan 30.
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, Japan.
    Background: It has been reported that some single-nucleotide polymorphisms (SNPs) in lipid regulators such as apolipoproteins and cell surface molecules for hepatitis C virus (HCV) entry into hepatocytes are associated with HCV infection. However, it is unknown how HCV infection is affected by altered lipid metabolism resulting from the SNPs. We investigated the relationship between these SNPs and HCV infection status, and also analyzed the mechanism by which these SNPs mediate HCV infection via lipid metabolism alterations. Read More

    Therapeutic preferences and outcomes in newly diagnosed patients with Crohn's diseases in the biological era in Hungary: a nationwide study based on the National Health Insurance Fund database.
    BMC Gastroenterol 2018 Jan 30;18(1):23. Epub 2018 Jan 30.
    1st Department of Medicine, Semmelweis University, Budapest, H-1083, Hungary.
    Background: Accelerated treatment strategy, including tight disease control and early aggressive therapy with immunosuppressives (IS) and biological agents have become increasingly common in inflammatory bowel disease (IBD). The aim of the present study was to estimate the early treatment strategy and outcomes in newly diagnosed patients with Crohn's disease (CD) between 2004 and 2008 and 2009-2015 in the whole IBD population in Hungary based on the administrative database of the National Health Insurance Fund (OEP).

    Methods: We used the administrative database of the OEP, the only nationwide state-owned health insurance provider in Hungary. Read More

    Is perceived intolerance to milk and wheat associated with the corresponding IgG and IgA food antibodies? A cross sectional study in subjects with morbid obesity and gastrointestinal symptoms.
    BMC Gastroenterol 2018 Jan 30;18(1):22. Epub 2018 Jan 30.
    Department of Research, Innlandet Hospital Trust, Brumunddal, Norway.
    Background: Serum IgG and IgA food antibodies have been used for dietary advice to subjects with gastrointestinal symptoms and perceived food intolerance, but the role of these antibodies in mediating intolerance is controversial. The present study investigated associations between perceived gastrointestinal intolerance to milk-or wheat and the corresponding s-IgG and s-IgA food antibodies in subjects with morbid obesity.

    Methods: Subjects with morbid obesity (BMI ≥ 40 kg/mor ≥35 kg/mwith obesity-related complications) were included. Read More

    Epidemiology of gastrointestinal symptoms in young and middle-aged Swiss adults: prevalences and comorbidities in a longitudinal population cohort over 28 years.
    BMC Gastroenterol 2018 Jan 27;18(1):21. Epub 2018 Jan 27.
    Department of Psychiatry und Psychotherapy, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
    Background: Although subacute and chronic gastrointestinal symptoms are very common in primary care, epidemiological date are sparse. The aim of the study was to examine and quantify the prevalence of subacute and chronic gastrointestinal symptoms and their associations with somatic and mental disorders in the general population.

    Methods: Data were collected prospectively between 1981 (age m = 22, f = 23) and 2008 (age 49/50) from the Zurich Cohort Study (n = 292 men, 299 women), a representative general population survey. Read More

    Gastric bacterial Flora in patients Harbouring Helicobacter pylori with or without chronic dyspepsia: analysis with matrix-assisted laser desorption ionization time-of-flight mass spectroscopy.
    BMC Gastroenterol 2018 Jan 26;18(1):20. Epub 2018 Jan 26.
    Division of Microbiology, P D Hinduja Hospital, Mumbai, India.
    Background: The gastric microbiota has recently been implicated in the causation of organic/structural gastroduodenal diseases (gastric and duodenal ulcers, gastric cancer) in patients with Helicobacter pylori (H. pylori) infection. We aimed to ascertain, in patients harbouring H. Read More

    Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio can predict the severity of gallstone pancreatitis.
    BMC Gastroenterol 2018 Jan 25;18(1):18. Epub 2018 Jan 25.
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju-si, 26426, Republic of Korea.
    Background: Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) predict severity in various diseases. In this study, we evaluated the value of NLR and PLR as prognostic factors in acute pancreatitis (AP).

    Methods: Patients with AP were prospectively enrolled from March 2014 to September 2016 at Yonsei University Wonju College of Medicine. Read More

    Circular stripes were more common in Barrett's esophagus after acetic acid staining.
    BMC Gastroenterol 2018 Jan 25;18(1):17. Epub 2018 Jan 25.
    Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an, Shaanxi, 710004, China.
    Background: The diagnosis of Barrett's esophagus (BE) is disturbed by numerous factors, including correct gastroesophageal junction judgment, the initial location of the Z-line and the biopsy result above it. The acetic acid (AA) could help to diagnose BE better than high resolution imaging technology or magnifying endoscopy, by providing enhanced contrast of different epithelium. We have noticed AA could produce multiple white circular lines, forming circular stripes (CS), at lower esophagus, which hasn't been reported by others. Read More

    Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control.
    BMC Gastroenterol 2018 Jan 25;18(1):19. Epub 2018 Jan 25.
    Italian Liver Foundation, Centro Studi Fegato, AREA Science Park, Bldg. Q, Ss 14, km 163.5, 34149, Trieste, Italy.
    Background: Peripheral neuropathy is one most common, limiting and invalidating neurological symptom in subjects with hepatitis C virus and mixed cryoglobulinemia. Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. Therefore, neuropathy therapies are insufficient and inadequate, and comprise immunosuppressive drugs, such as steroid or cyclosporine, intravenous immunoglobulin or plasma exchange. Read More

    Rate and determinants of non-adherence to a gluten-free diet and nutritional status assessment in children and adolescents with celiac disease in a tertiary Brazilian referral center: a cross-sectional and retrospective study.
    BMC Gastroenterol 2018 Jan 19;18(1):15. Epub 2018 Jan 19.
    Department of Pediatric, Instituto da Criança, Division of Nutrition, Hospital das Clínicas, School of Medicine, University of Sao Paulo (SMUSP), Sao Paulo, Brazil.
    Background: Compliance with a gluten-free diet (GFD) is difficult at all ages but particularly for teenagers due to social, cultural, economic, and practical pressures. The multidisciplinary team responsible for the treatment of patients with celiac disease and give support to their parents plays a special role on strengthening GFD and assessing the nutritional and physical health.

    Methods: A cross-sectional and retrospective study including patients under 20 years of age, with biopsy-confirmed CD, followed regularly at the Department of Pediatrics, Division of Gastroenterology, Hospital das Clínicas, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil, were surveyed using a questionnaire and serologic test applied between November 2011 and February 2012. Read More

    Treatment of long-segment Barrett's adenocarcinoma by complete circular endoscopic submucosal dissection: a case report.
    BMC Gastroenterol 2018 Jan 19;18(1):16. Epub 2018 Jan 19.
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
    Background: We present the first description of en bloc endoscopic submucosal dissection (ESD) for total circumferential Barrett's adenocarcinoma, predominantly of the long-segment Barrett's esophagus (LSBE), with a 2-year follow-up and management strategies for esophageal stricture prevention.

    Case Presentation: A 59-year-old man was diagnosed with LSBE and Barrett's adenocarcinoma by esophagogastroduodenoscopy (EGD). A 55-mm-long circumferential tumor was completely resected by ESD. Read More

    Uninvestigated dyspepsia and associated factors of patients with gastrointestinal disorders in Dessie Referral Hospital, Northeast Ethiopia.
    BMC Gastroenterol 2018 Jan 18;18(1):13. Epub 2018 Jan 18.
    Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
    Background: Dyspepsia is a common problem in the community and clinical practice with symptom(s) considered arising from the gastroduodenal region. Dyspepsia burden and associated factors vary from country to country. The aim of this study was to determine the prevalence of uninvestigated dyspepsia (UD) using Rome III criteria, associated risk factors and self-reported dyspepsia symptoms' correlation with H. Read More

    Endoscopic balloon dilatation for benign hepaticojejunostomy anastomotic stricture using short double-balloon enteroscopy in patients with a prior Whipple's procedure: a retrospective study.
    BMC Gastroenterol 2018 Jan 18;18(1):14. Epub 2018 Jan 18.
    Department of Gastroenterology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama-city, Okayama, 700-8558, Japan.
    Background: Endoscopic retrograde cholangiography using a short double-balloon endoscope (DB-ERC) is a promising minimally-invasive method for accessing hepaticojejunostomy (HJ) anastomosis in patients with surgically altered anatomy. We aimed to evaluate the immediate and long-term outcomes of balloon dilatation for benign HJ anastomotic stricture (HJAS) in patients who had previously undergone Whipple's procedure using a DB-ERC.

    Methods: We conducted a retrospective analysis of 46 patients who underwent balloon dilatation alone with a DB-ERC for benign HJAS between November 2008 and November 2014. Read More

    SSH1 expression is associated with gastric cancer progression and predicts a poor prognosis.
    BMC Gastroenterol 2018 Jan 16;18(1):12. Epub 2018 Jan 16.
    Department of General Surgery (Research Institute of Minimally Invasive), People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830000, China.
    Background: Slingshot homolog-1 (SSH1) plays an important role in pathological processes, including in the occurrence and development of tumours. The purpose of this study was to determine whether SSH1 is a key biomarker with prognostic value for survival in patients with gastric cancer.

    Methods: We performed immunohistochemistry (IHC) on tissue microarrays containing 100 gastric cancer specimens to evaluate SSH1 protein expression. Read More

    Enteral immunonutrition versus enteral nutrition for gastric cancer patients undergoing a total gastrectomy: a systematic review and meta-analysis.
    BMC Gastroenterol 2018 Jan 16;18(1):11. Epub 2018 Jan 16.
    School of medicine and life sciences, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing, China.
    Background: Nutrition support is a common means for patients with gastric cancer, especially for those undergoing elective surgery. Recently, enteral immunonutrition (EIN) was increasingly found to be more effective than enteral nutrition (EN) in enhancing the host immunity and eventually improving the prognosis of gastric cancer patients undergoing gastrectomy. However, the results reported were not consistent. Read More

    Efficacy comparison of multi-phase CT and hepatotropic contrast-enhanced MRI in the differential diagnosis of focal nodular hyperplasia: a prospective cohort study.
    BMC Gastroenterol 2018 Jan 15;18(1):10. Epub 2018 Jan 15.
    2nd Departement of Radiology, Medical University of Gdansk, Smoluchowskiego 17, 80-214, Gdansk, Poland.
    Background: Different clinical behaviour influences the importance of differentiating focal nodular hyperplasia (FNH) from other focal liver lesions (FLLs). The aim of this study was to compare the efficacy of contrast-enhanced CT and MRI in the diagnosis of FNH.

    Methods: 157 patients with equivocal FLLs detected in ultrasonography subsequently underwent multi-phase CT and MRI with the use of hepatotropic contrast agent (Gd-BOPTA) in a 1. Read More

    Mesenteric inflammatory veno-occlusive disease occurring during the course of ulcerative colitis: a case report.
    BMC Gastroenterol 2018 Jan 11;18(1). Epub 2018 Jan 11.
    Department of Gastroenterology, Seirei Hamamatsu General Hospital, Hamamatsu, 430-8558, Japan.
    Background: Mesenteric inflammatory veno-occlusive disease (MIVOD) is difficult to diagnose because of its rarity, nonspecific clinical findings, and frequent confusion with other diseases including inflammatory bowel disease. This report presents a very rare case of MIVOD that occurred during the course of ulcerative colitis (UC).

    Case Presentation: A 32-year-old man, who had been diagnosed with UC at the age of 29 and was in remission maintained by oral administration of 5-aminosalicylic acid (5-ASA), showed exacerbation of diarrhea and was admitted to the hospital. Read More

    Prevalence and key radiographic spinal malalignment parameters that influence the risk for gastroesophageal reflux disease in patients treated surgically for adult spinal deformity.
    BMC Gastroenterol 2018 Jan 10;18(1). Epub 2018 Jan 10.
    Department of Orthopaedics, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi, 409-3898, Japan.
    Background: Gastroesophageal reflux disease (GERD) is a factor that has a significant negative impact on the quality of life (QoL). Vertebral fractures and/or spinal malalignment may influence the frequency of GERD. However, the epidemiology and pathology of GERD in patients with adult spinal deformity (ASD) are still largely unknown. Read More

    How disease extent can be included in the endoscopic activity index of ulcerative colitis: the panMayo score, a promising scoring system.
    BMC Gastroenterol 2018 Jan 8;18(1). Epub 2018 Jan 8.
    First Department of Medicine, University of Szeged, H6720, Korányi fasor 8-10, Szeged, 6720, Hungary.
    Background: Colonoscopy plays crucial role in the establishment of the diagnosis, management and follow-up of ulcerative colitis (UC). None of the currently widely used endoscopic scores consider disease extent, and therefore do not correlate with the real severity of UC. Our aim was to assess the accuracy of a new score, the Pancolonic Modified Mayo Score that can reflect not only the severity, but the extent of active UC. Read More

    Hepatitis B reactivation among 1962 patients with hematological malignancy in Taiwan.
    BMC Gastroenterol 2018 Jan 8;18(1). Epub 2018 Jan 8.
    Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, 10002, Taiwan.
    Background: The risk of Hepatitis B virus (HBV) reactivation in patients with different hematological malignancy except lymphoma were rarely known before.

    Methods: A total of 1962 patients with hematological malignancy were enrolled and followed-up at the National Taiwan University Hospital between 2008 and 2013. The clinical characteristics, HBV serology, and laboratory data were retrospectively reviewed and analyzed. Read More

    Correction to: Helicobacter-induced gastric inflammation alters the properties of gastric tissue stem/progenitor cells.
    BMC Gastroenterol 2018 Jan 8;18(1). Epub 2018 Jan 8.
    Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    Correction: Unfortunately, the original article [1] contained an error incorporated during production. A duplicated version of Table 1 was published in place of Table 2. Table 2 has been corrected in the original article and is also included correctly below. Read More

    Ramosetron for the treatment of irritable bowel syndrome with diarrhea: a systematic review and meta-analysis of randomized controlled trials.
    BMC Gastroenterol 2018 Jan 8;18(1). Epub 2018 Jan 8.
    Department of Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong Province, 250012, China.
    Background: Ramosetron is a potent and selective serotonin type 3 receptor antagonist. This meta-analysis aimed to analyze the efficacy and safety of ramosetron for irritable bowel syndrome with diarrhea (IBS-D).

    Methods: Pubmed, MEDLINE, EMBASE and the Cochrane Library were searched for randomized controlled trials investigating the efficacy and safety of ramosetron for IBS-D. Read More

    Cobalt chloride compromises transepithelial barrier properties of CaCo-2 BBe human gastrointestinal epithelial cell layers.
    BMC Gastroenterol 2018 Jan 5;18(1). Epub 2018 Jan 5.
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA, 19096, USA.
    Background: Elevation of the transcription factor HIF-1 is a prominent mediator of not only processes that accompany hypoxia, but also the tumor microenvironment and tissue regeneration. This study uses mediators of "chemical hypoxia" to ask the question whether HIF-1α elevation in a healthy epithelial cell layer leads to leakiness in its tight junctional seals.

    Methods: Transepithelial electrical resistance and transepithelial diffusion ofC-D-mannitol and other radiolabeled probes are used as indicators of transepithelial barrier function of CaCo-2 BBe human gastrointestinal epithelial cell layers cultured on permeable supports. Read More

    Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial.
    BMC Gastroenterol 2018 Jan 5;18(1). Epub 2018 Jan 5.
    , Lexington, USA.
    Background: Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol. Apical sodium-dependent bile acid transporter (ASBT) inhibition in the terminal ileum may facilitate removal of free cholesterol from the liver by reducing recirculation of bile acids (BAs) to the liver, thereby stimulating new BA synthesis from cholesterol. The aim of this phase 1 study in adult healthy volunteers (HVs) and patients with type 2 diabetes mellitus (T2DM) was to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ASBT inhibition with volixibat (SHP626; formerly LUM002). Read More

    Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients.
    BMC Gastroenterol 2018 Jan 4;18(1). Epub 2018 Jan 4.
    Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, I.R.C.C.S. Fondazione Cà Granda, Ospedale Maggiore Policlinico, via Pace 9, 20122, Milan, Italy.
    Background: Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. Read More

    Streptococcus agalactiae infective endocarditis complicated by multiple mycotic hepatic aneurysms and massive splenic infarction: a case report.
    BMC Gastroenterol 2017 Dec 29;17(1):170. Epub 2017 Dec 29.
    Department of Surgery, Ospedale Alessandro Manzoni, Lecco, Via dell'Eremo 9/11, 23900, Lecco, Italy.
    Background: The burden of disease caused by Streptococcus agalactiae has increased significantly among older adults in the last decades. Group B streptococcus infection can be associated with invasive disease and severe clinical syndromes, such as meningitis and endocarditis.

    Case Presentation: We present the case of a 56-year-old man who developed multiple mycotic aneurysms of the right hepatic artery and massive splenic infarction as rare complications of Streptococcus agalactiae infective endocarditis. Read More

    CCL4 is the only predictor for non-responder in GT-1 CHC patients with favorable IL28B genotype when treated with PegIFN/RBV.
    BMC Gastroenterol 2017 Dec 29;17(1):169. Epub 2017 Dec 29.
    School of Medicine, College of Medicine, Chang-Gung University, 5, Fu-Xin street, Quain San, TaoYuan, 330, Taiwan.
    Background: Chemokines/cytokines play important roles in the pathogenesis of chronic hepatitis C (CHC). However, their clinical characteristics and implications in treatment responses to pegylated interferon plus ribavirin treatment (PegIFN/RBV) have not been fully illustrated yet. In this study, we intended to investigate the possible predictability of serum chemokines/cytokines on the treatment response in Taiwanese of CHC, genotype-1 (GT-1). Read More

    Prediction of posthepatectomy liver failure using transient elastography in patients with hepatitis B related hepatocellular carcinoma.
    BMC Gastroenterol 2017 Dec 29;17(1):171. Epub 2017 Dec 29.
    Department of Ultrasound, Eastern Hepatobiliary Surgery Hospital (EHBH), Second Military Medical University, Shanghai, China.
    Background: It is essential to accurately predict Postoperative liver failure (PHLF) which is a life-threatening complication. Liver hardness measurement (LSM) is widely used in non-invasive assessment of liver fibrosis. The aims of this study were to explore the application of preoperative liver stiffness measurements (LSM) by transient elastography in predicting postoperative liver failure (PHLF) in patients with hepatitis B related hepatocellular carcinoma. Read More

    Upcoming pharmacological developments in chronic hepatitis B: can we glimpse a cure on the horizon?
    BMC Gastroenterol 2017 Dec 21;17(1):168. Epub 2017 Dec 21.
    Unit of Gastroenterology, Hospital Universitario Fundación Alcorcón, Av. Budapest-1, 28922, Alcorcon, Madrid, Spain.
    Background: Hepatitis B virus (HBV) chronic infection affects up to 240 million people in the world and it is a common cause of cirrhosis and hepatocellular carcinoma (HCC). HBV covalently closed circular DNA (cccDNA) plays an essential role in HBV persistence and replication. Current pharmacological treatment with nucleos(t)ide analogues (NA) may suppress HBV replication with little or no impact on cccDNA, hence lifelong treatment is required in the vast majority of patients. Read More

    Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery: study protocol for a randomized controlled trial (UPGRADE trial).
    BMC Gastroenterol 2017 Dec 20;17(1):164. Epub 2017 Dec 20.
    Department of gastroenterology & hepatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, the Netherlands.
    Background: The number of bariatric interventions for morbid obesity is increasing worldwide. Rapid weight loss is a major risk factor for gallstone development. Approximately 11 % of patients who underwent Roux-en-Y gastric bypass develop symptomatic gallstone disease. Read More

    Risk factors for mortality among patients admitted with upper gastrointestinal bleeding at a tertiary hospital: a prospective cohort study.
    BMC Gastroenterol 2017 Dec 20;17(1):165. Epub 2017 Dec 20.
    Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
    Background: Upper gastrointestinal bleeding (UGIB) is a common gastrointestinal emergency, which is potentially fatal. Proper management of UGIB requires risk-stratification of patients which can guide the type and aggressiveness of management. The aim of this was study was identify the causes of UGIB and factors that increase the risk of mortality in these patients. Read More

    Primary pancreatic plasmacytoma: a rare case report.
    BMC Gastroenterol 2017 Dec 20;17(1):167. Epub 2017 Dec 20.
    Department of Gastrointestinal Surgery, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, 32 West Second Section, First Ring Road, Chengdu, Sichuan, 610072, China.
    Background: Extramedullary plasmacytoma is a very rare tumor derived from plasma cells and found outside the bone marrow. Most have been identified in patients with the more aggressive anaplastic form of the disease. Only a few cases of primary pancreatic plasmacytoma have been reported. Read More

    A rare cause of acute liver failure- a case report.
    BMC Gastroenterol 2017 Dec 20;17(1):166. Epub 2017 Dec 20.
    Departament of Gastroenterology and Hepatology, Hospital de Santa Maria, CHLN.Av. Prof. Egas Moniz, 1649-028, Lisbon, Portugal.
    Background: Acute liver failure (ALF) induced by diffuse metastatic disease has rarely been reported.

    Case Presentation: We present a 51-years-old woman with relevant clinical history for breast cancer. The patient was admitted in the emergency department with jaundice, dark urine and pale stools. Read More

    The red distribution width and the platelet distribution width as prognostic predictors in gastric cancer.
    BMC Gastroenterol 2017 Dec 20;17(1):163. Epub 2017 Dec 20.
    Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China.
    Background: Increasing attention is focused on the relationship of inflammation biomarkers with malignant tumors. The purpose of the present study was to detect whether the preoperative the red distribution width (RDW) and the platelet distribution width (PDW) can be used to distinguish patients with gastric cancer (GC) or early stage GC from the healthy controls and predict the progression and prognosis of the GC.

    Methods: The RDW and PDW values of 227 patients with GC and 164 patients with early GC were retrospectively analyzed comparing with 101 healthy controls. Read More

    Multiparametric functional magnetic resonance imaging for evaluation of hepatic warm ischemia-reperfusion injury in a rabbit model.
    BMC Gastroenterol 2017 Dec 15;17(1):161. Epub 2017 Dec 15.
    Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu, China.
    Background: To assess the feasibility of noninvasive and quantitative evaluation of hepatic pathophysiological changes in rabbit hepatic warm ischemia-reperfusion injury (WIRI) models by using intravoxel incoherent motion (IVIM), diffusion tensor imaging (DTI) and blood oxygen level dependent (BOLD) MRI.

    Methods: Twenty rabbits were randomly divided into hepatic WIRI model group and sham-operation group (n = 10 for each group). Hepatic WIRI was induced in rabbit by occluding hepatic inflow for 30 min and reperfusion for 6 h. Read More

    Colonoscopy overuse in colorectal cancer screening and associated factors in Argentina: a retrospective cohort study.
    BMC Gastroenterol 2017 Dec 15;17(1):162. Epub 2017 Dec 15.
    Family and Community Medicine Division, Hospital Italiano de Buenos Aires, Tte. Gral. Perón, 4272, Ciudad Autónoma de Buenos Aires, Argentina.
    Background: In recent years, there has been growing concern about the overuse of colonoscopy (CC). Our objective was to evaluate the incidence rate and cumulative probability of having a potentially inadequate CC (PI-CC, e.g. Read More

    Psychological wellbeing and physical activity in children and adolescents with inflammatory bowel disease compared to healthy controls.
    BMC Gastroenterol 2017 Dec 12;17(1):160. Epub 2017 Dec 12.
    Psychiatric Clinics of the University of Basel, Centre for Affective, Stress and Sleep Disorders, University of Basel, Wilhelm Klein-Strasse 27, Ch-4012, Basel, Switzerland.
    Background: Children and adolescents with inflammatory bowel disease (IBD) report impairments in daily activities, social interactions and coping. Findings regarding psychological functioning are inconsistent, while limited information is available on objectively assessed physical activity (PA). The aims of the present study were therefore to compare anthropometric dimensions, blood values, psychological functioning and PA of children and adolescents with IBD with healthy controls. Read More

    Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma.
    BMC Gastroenterol 2017 Dec 12;17(1):158. Epub 2017 Dec 12.
    Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
    Background: Serrated adenocarcinoma (SAC) is a distinct colorectal carcinoma variant that accounts for approximately 7.5% of all advanced colorectal carcinomas. While its prognosis is worse than conventional carcinoma, its early-stage clinicopathologic features are unclear. Read More

    Evaluation of scoring systems without endoscopic findings for predicting outcomes in patients with upper gastrointestinal bleeding.
    BMC Gastroenterol 2017 Dec 12;17(1):159. Epub 2017 Dec 12.
    Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, 892 Dongnam-ro, Gangdong-gu, Seoul, 05278, South Korea.
    Background: Risk scoring systems are used to evaluate patients with upper gastrointestinal bleeding (UGIB). We compared Glasgow-Blatchford score (GBS), modified GBS (mGBS), and Pre-endoscopy Rockall score (Pre-E RS) for immediate application without endoscopic findings in predicting the need of interventions and the 30-day mortality in patients with UGIB.

    Methods: Patients who visited the emergency room with UGIB from January 2007 to June 2016 were included. Read More

    Adenocarcinoma risk in gastric atrophy and intestinal metaplasia: a systematic review.
    BMC Gastroenterol 2017 Dec 11;17(1):157. Epub 2017 Dec 11.
    Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.
    Background: Gastric cancer (GC) has a poor prognosis with wide variation in survival rates across the world. Several studies have shown premalignant lesions gastric atrophy (GA) and intestinal metaplasia (IM) influence gastric cancer risk. This systematic review examines all available evidence of the risk of GC in patients with GA or IM and explores the geographical variation between countries. Read More

    Self-reported dietary adherence, disease-specific symptoms, and quality of life are associated with healthcare provider follow-up in celiac disease.
    BMC Gastroenterol 2017 Dec 11;17(1):156. Epub 2017 Dec 11.
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
    Background: The only treatment for celiac disease (CeD) is a lifelong gluten-free diet (GFD). The restrictive nature of the GFD makes adherence a challenge. As an integral part of CeD management, multiple professional organizations recommend regular follow-up with a healthcare provider (HCP). Read More

    Time-varying serum gradient of hepatitis B surface antigen predicts risk of relapses after off-NA therapy.
    BMC Gastroenterol 2017 Dec 8;17(1):154. Epub 2017 Dec 8.
    School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan.
    Background: The serum gradient of hepatitis B surface antigen (HBsAg) varies over time after cessation of nucleos(t)ide analog (NA) treatment in patients with chronic hepatitis B (CHB). The association between the time-varying HBsAg serum gradient and risk of relapse has not been elucidated.

    Methods: This multicenter cohort study prospectively enrolled CHB patients who discontinued 3 year-NA treatment. Read More

    Double-catheter lavage combined with percutaneous flexible endoscopic debridement for infected pancreatic necrosis failed to percutaneous catheter drainage.
    BMC Gastroenterol 2017 Dec 8;17(1):155. Epub 2017 Dec 8.
    Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People's Republic of China.
    Background: Infected pancreatic necrosis (IPN) is a serious local complication of acute pancreatitis, with high mortality. Minimally invasive therapy including percutaneous catheter drainage (PCD) has become the preferred method for IPN instead of traditional open necrosectomy. However, the efficacy of double-catheter lavage in combination with percutaneous flexible endoscopic debridement after PCD failure is unknown compared with surgical necrosectomy. Read More

    Sex and ethnic/racial-specific risk factors for gallbladder disease.
    BMC Gastroenterol 2017 Dec 8;17(1):153. Epub 2017 Dec 8.
    Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
    Background: Gallbladder disease (GBD) is a highly prevalent condition; however, little is known about potential differences in risk factors by sex and ethnicity/race. Our aim was to evaluate dietary, reproductive and obesity-related factors and GBD in multiethnic populations.

    Methods: We performed a prospective analysis from the Multiethnic Cohort study who self-identified as non-Hispanic White (n = 32,103), African American (n = 30,209), Japanese (n = 35,987), Native Hawaiian (n = 6942) and Latino (n = 39,168). Read More

    Magnetic resonance imaging analysis of brain function in patients with irritable bowel syndrome.
    BMC Gastroenterol 2017 Dec 8;17(1):148. Epub 2017 Dec 8.
    Department of Gastroenterology, Lihuili Hospital of Ningbo Medical Center, 57# Xingning Road, Ningbo, 315000, China.
    Background: Irritable bowel syndrome (IBS) is a common functional disease of the gastrointestinal tract. The current study aimed to examine the association between visceral hypersensitivity in IBS and cortical activation using functional magnetic resonance imaging (fMRI), and to elucidate the role of psychological factors in the pathogenesis of IBS.

    Methods: The present study included 31 patients with IBS and 20 healthy controls. Read More

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