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    1691 results match your criteria BMC Gastroenterology[Journal]

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    Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer.
    BMC Gastroenterol 2017 Sep 15;17(1):104. Epub 2017 Sep 15.
    Department of Biology, University of Pisa, Via Derna 1, 56100, Pisa, Italy.
    Background: Genetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymorphic variants. However, these loci only explain around 1‑4% of CRC heritability, highlighting the dire need of identifying novel risk loci. Read More

    Estimation of utility weights for major liver diseases according to disease severity in Korea.
    BMC Gastroenterol 2017 Sep 5;17(1):103. Epub 2017 Sep 5.
    Department of Preventive Medicine, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, South Korea.
    Background: The global burden of liver diseases, such as hepatocellular carcinoma and liver cirrhosis, is substantial. In this study, we estimated utility weights of liver disease-related health states in the general population using a visual analogue scale (VAS) and the standard gamble (SG) method.

    Methods: Depictions of standardized health states related to major liver diseases were developed based on patient education materials and previous publications. Read More

    Addition of nucleoside analogues to peg-IFNα-2a enhances virological response in chronic hepatitis B patients without early response to peg-IFNα-2a: a randomized controlled trial.
    BMC Gastroenterol 2017 Aug 30;17(1):102. Epub 2017 Aug 30.
    Department of Gastroenterology, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, 130033, China.
    Background: Current treatments for chronic hepatitis B (CHB) include pegylated interferon alpha (PEG-IFN-α) which is an immune modulator, and nucleos(t)ide analogs (NAs) which directly inhibit HBV DNA polymerase. With the limited efficacy of PEG-IFN-α and prolonged treatment periods associated with NAs, there is an urgent need for novel therapeutic strategies, especially for patients with a poor early response to anti-viral therapy.

    Methods: In this study, 178 patients with chronic hepatitis B (n = 131) and compensated (n = 47) HBV-induced cirrhosis were enrolled, 120 patients with HBeAg (+). Read More

    Diminished accuracy of biomarkers of fibrosis in low replicative chronic hepatitis B.
    BMC Gastroenterol 2017 Aug 25;17(1):101. Epub 2017 Aug 25.
    Department of Gastroenterology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
    Background: We evaluated the diagnostic accuracy of aspartate aminotransferase (AST)-to-platelet ratio index (APRI), fibrosis-4 index (FIB-4), AST/alanine aminotransferase (ALT) ratio (AAR), and age-platelet index (API) for significant fibrosis (Metavir F2-4) in low-replicative (HBV DNA <20,000 IU/mL) chronic hepatitis B virus (HBV) patients.

    Methods: The sensitivity, specificity, and area under the receiver-operating characteristic curve (AUROC) of HBeAg-negative, low-replicative (n = 213) and high-replicative (HBV DNA ≥20,000 IU/mL, n = 153) patients was assessed.

    Results: Overall, 113 patients (30. Read More

    Protective effects of heme oxygenase-1 against severe acute pancreatitis via inhibition of tumor necrosis factor-α and augmentation of interleukin-10.
    BMC Gastroenterol 2017 Aug 24;17(1):100. Epub 2017 Aug 24.
    Department of Emergency Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jingshi Road No.16369, Jinan, Shandong Province, 250011, China.
    Background: Heme oxygenase-1 (HO-1) is an inducible defense gene which plays a significant role in inflammation. HO-1 protects cells and tissues through the mechanism of anti-oxidation, maintaining microcirculation and anti-inflammation. The aim of the current study is to investigate the role of HO-1 on systemic inflammatory response in severe acute pancreatitis (SAP). Read More

    Add-on neurological benefits of antiviral therapy in HCV patients with chronic kidney disease - a nationwide cohort study.
    BMC Gastroenterol 2017 Aug 16;17(1):99. Epub 2017 Aug 16.
    School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan County, Taiwan.
    Background: Hepatitis C virus (HCV)-infected patients with chronic kidney disease (CKD) have rarely been studied because they rarely accept interferon-based therapy (IBT) and have been difficult to follow up. We investigated long-term outcomes of IBT on the population.

    Methods: This population-based cohort study used the Taiwan National Health Insurance Research Database as its data source. Read More

    Survival benefit of transarterial chemoembolization in patients with metastatic hepatocellular carcinoma: a single center experience.
    BMC Gastroenterol 2017 Aug 10;17(1):98. Epub 2017 Aug 10.
    Department of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, D-79106, Freiburg, Germany.
    Background: As prognosis of patients with metastatic hepatocellular carcinoma (HCC) is mainly determined by intrahepatic HCC progression, local treatment with TACE may result in improved OS, although it is not recommended. The purpose of this study was to analyze retrospectively the efficacy of TACE and its impact on OS in patients with metastatic hepatocellular carcinoma (HCC).

    Methods: Two hundred and fifteen patients with metastatic HCC who were treated at our Liver Center between 2003 and 2014 were included in this retrospective analysis. Read More

    Drug persistence and need for dose intensification to adalimumab therapy; the importance of therapeutic drug monitoring in inflammatory bowel diseases.
    BMC Gastroenterol 2017 Aug 8;17(1):97. Epub 2017 Aug 8.
    First Department of Medicine, Semmelweis University, Koranyi S 2A, Budapest, H-1083, Hungary.
    Background: Therapeutic drug monitoring (TDM) aid therapeutic decision making in patients with inflammatory bowel disease (IBD) who lose response to anti-TNF therapy. Our aim was to evaluate the frequency and predictive factors of loss of response (LOR) to adalimumab using TDM in IBD patients.

    Methods: One hundred twelve IBD patients (with 214 TDM measurements, CD/UC 84/28, male/female 50/62, mean age CD/UC: 36/35 years) were enrolled in this consecutive cohort from two referral centres in Hungary. Read More

    Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study.
    BMC Gastroenterol 2017 Aug 8;17(1):96. Epub 2017 Aug 8.
    Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    Background: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD).

    Methods: The study was an open label, single arm, multicenter, pilot trial. Read More

    Lichenoid esophagitis presenting as fatal upper gastrointestinal bleeding in a 52 year-old woman: a case diagnosed by autopsy.
    BMC Gastroenterol 2017 Aug 8;17(1):95. Epub 2017 Aug 8.
    Department of Anatomical Pathology and Cytology, Maisonneuve-Rosemont Hospital, 5415 Boulevard de L'Assomption, Montreal, Quebec, H1T 2M4, Canada.
    Background: "Lichenoid esophagitis" is a descriptive term for a lichenoid pattern of inflammation in the esophagus for which a precise histologic diagnosis cannot be established. The differential diagnosis includes lichen planus, a drug-related reaction, and viral infection. Lichenoid esophagitis causing death has not been reported previously. Read More

    A superficial esophageal cancer in an epiphrenic diverticulum treated by endoscopic submucosal dissection.
    BMC Gastroenterol 2017 Aug 7;17(1):94. Epub 2017 Aug 7.
    Department of Gastroenterology, PLA Army General Hospital, Beijing, 100700, China.
    Background: We report a unique case of a superficial esophageal cancer arising in a single diverticulum, diagnosed with magnifying image-enhanced endoscopy and then successfully treated by endoscopic submucosal dissection (ESD).

    Case Presentation: A 66-year-old man with alcohol-related liver injury visited our hospital for endoscopy for investigation of varix. Esophagogastroduodenoscopy showed no varix but a large epiphrenic diverticulum with an area of fainted redness just above the esophagogastric junction. Read More

    A case report of prostate cancer metastasis to the stomach resembling undifferentiated-type early gastric cancer.
    BMC Gastroenterol 2017 Aug 7;17(1):93. Epub 2017 Aug 7.
    Hara Clinic, 228-1, Haraoka, Tomiura-cyo, Minamibousou-shi, Chiba, 299-2403, Japan.
    Background: Occurrence of metastatic cancer to the stomach is rare, particularly in patients with prostate cancer. Gastric metastasis generally presents as a solitary and submucosal lesion with a central depression.

    Case Presentation: We describe a case of gastric metastasis arising from prostate cancer, which is almost indistinguishable from the undifferentiated-type gastric cancer. Read More

    Oral soft tissue disorders are associated with gastroesophageal reflux disease: retrospective study.
    BMC Gastroenterol 2017 Aug 7;17(1):92. Epub 2017 Aug 7.
    Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
    Background: Dental erosion (DE), one of oral hard tissue diseases, is one of the extraoesophageal symptoms defined as the Montreal Definition and Classification of gastroesophageal reflux disease (GERD). However, no study evaluated the relationship between GERD and oral soft tissues. We hypothesized that oral soft tissue disorders (OSTDs) would be related to GERD. Read More

    Abnormalities in ileal stem, neurogenin 3, and enteroendocrine cells in patients with irritable bowel syndrome.
    BMC Gastroenterol 2017 Aug 1;17(1):90. Epub 2017 Aug 1.
    Section for Gastroenterology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
    Background: This study examined whether the densities of stem- and enteroendocrine cell progenitors are abnormal in the ileum of patients with irritable bowel syndrome (IBS), and whether any abnormalities in ileal enteroendocrine cells are correlated with abnormalities in stem cells and enteroendocrine cell progenitors.

    Methods: One hundred and one IBS patients covering all IBS subtypes were recruited, and 39 non-IBS subjects were included as a control group. The patients and controls underwent standard colonoscopies, during which biopsy specimens were obtained from the ileum. Read More

    Tissue sublimation follow transarterial embolization of a follicular nodular hyperplasia of the liver-report of a case.
    BMC Gastroenterol 2017 Aug 1;17(1):91. Epub 2017 Aug 1.
    Department of Surgery, Helios University Hospital Wuppertal, Witten - Herdecke University, Heusnerstr. 40, 42283, Wuppertal, Germany.
    Background: Follicular nodular hyperplasia (FNH) is a common benign liver tumor for which conservative management is indicated. Surgical or interventional management is indicated in symptomatic cases. Transarterial embolization (TAE) has been extensively used to manage unresectable liver tumors. Read More

    Life-threatening bleeding from gastric dieulafoy's lesion in a pregnant woman with hellp syndrome: a case report and literature review.
    BMC Gastroenterol 2017 Jul 31;17(1):89. Epub 2017 Jul 31.
    Department of Gastroenterology, Affiliated Provincial Hospital of Anhui Medical University, Hefei, China.
    Background: Dieulafoy's lesion (DL) is one of the rare causes of upper gastrointestional bleeding. This disease is characterized by small sub-mucosal arteriole that eroded the stomach mucosa and cause severe upper GI bleeding without obvious ulceration. The most common location is fundus area of stomach and usually affects patients over 50 years of age with multiple comorbidities. Read More

    The potential value of serum pepsinogen for the diagnosis of atrophic gastritis among the health check-up populations in China: a diagnostic clinical research.
    BMC Gastroenterol 2017 Jul 20;17(1):88. Epub 2017 Jul 20.
    International HealthCare Center, The Second Affiliated Hospital of Zhejiang University, School of Medicine, NO.88 Jiefang Road, Hangzhou, Zhejiang Province, People's Republic of China.
    Background: The aim of this study is to assess the validity of the measurement of pepsinogen as a screening test for chronic atrophic gastritis (AG) in health check-up populations in China.

    Methods: Patients from consecutive regular health check-up were enrolled from January 2014 to June 2015. Endoscopy, combined with monitoring the Helicobacter pylori (Hp) infections, and measuring the serum pepsinogen (PG) were used to determine the diagnostic accuracy of PG for the screening of atrophic gastritis. Read More

    The prevalence of gastric heterotopia of the proximal esophagus is underestimated, but preneoplasia is rare - correlation with Barrett's esophagus.
    BMC Gastroenterol 2017 Jul 12;17(1):87. Epub 2017 Jul 12.
    Clinic of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University, Leipziger Str. 44, D 30120, Magdeburg, Germany.
    Background: The previously reported prevalence of gastric heterotopia in the cervical esophagus, also termed inlet patch (IP), varies substantially, ranging from 0.18 to 14%. Regarding cases with adenocarcinoma within IP, some experts recommend to routinely obtain biopsies from IP for histopathology. Read More

    Risk of colorectal cancer among immigrants to Ontario, Canada.
    BMC Gastroenterol 2017 Jul 6;17(1):85. Epub 2017 Jul 6.
    University of Toronto, Prevention and Cancer Control, Cancer Care Ontario, 620 University Avenue, Toronto, ON, M4, Canada.
    Background: The risk of colorectal cancer (CRC) varies around the world and between females and males. We aimed to compare the risk of CRC among immigrants to Ontario, Canada, to its general population.

    Methods: We used an exposure-control matched design. Read More

    Regulation of apoptosis is impaired in atrophic gastritis associated with gastric cancer.
    BMC Gastroenterol 2017 Jun 29;17(1):84. Epub 2017 Jun 29.
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany.
    Background: Gastric premalignant conditions, atrophic gastritis (AG) and intestinal metaplasia (IM) are characterized by an increase of proliferation and a reduction of apoptosis in epithelial cells. The epithelial cell kinetics in AG and IM in gastric mucosa adjacent to gastric cancer is still unclear. The aim of this study was to evaluate the epithelial cell turnover and expression of proliferation and apoptosis-related genes in gastric cancer (GC) and adjacent mucosa with atrophic gastritis or intestinal metaplasia (AG/IM GC+), as well as in atrophic gastritis or intestinal metaplasia mucosa of patients without GC (AG/IM GC-) and in control biopsy samples of non-transformed gastric mucosa (Control). Read More

    Prokinetics for the treatment of functional dyspepsia: Bayesian network meta-analysis.
    BMC Gastroenterol 2017 Jun 26;17(1):83. Epub 2017 Jun 26.
    Department of Internal Medicine, Hallym University College of Medicine, Chuncheon Sacred Heart Hospital, Sakju-ro 77, Chuncheon, Gangwon-do, 24253, Republic of Korea.
    Background: Controversies persist regarding the effect of prokinetics for the treatment of functional dyspepsia (FD). This study aimed to assess the comparative efficacy of prokinetic agents for the treatment of FD.

    Methods: Randomized controlled trials (RCTs) of prokinetics for the treatment of FD were identified from core databases. Read More

    miR-363-5p as potential prognostic marker for hepatocellular carcinoma indicated by weighted co-expression network analysis of miRNAs and mRNA.
    BMC Gastroenterol 2017 Jun 20;17(1):81. Epub 2017 Jun 20.
    Department of Oncology, The third people's hospital of Chengdu, Chengdu, 610031, China.
    Background: This study aimed to investigate potential miRNAs and genes associated with the prognosis of hepatocellular carcinoma (HCC).

    Methods: Weighted co-expression network analysis was utilized to analyze the mRNA and miRNA sequencing data of HCC from TCGA (The Cancer Genome Atlas) database. Significant network modules were identified, and then functions of genes in the gene network modules and target genes of miRNAs in the miRNA network modules were explored. Read More

    Role of serotonin on the intestinal mucosal immune response to stress-induced diarrhea in weaning mice.
    BMC Gastroenterol 2017 Jun 21;17(1):82. Epub 2017 Jun 21.
    Laboratory of Veterinary Anatomy, College of Animal Medicine, China Agricultural University, Haidian, Beijing, 100193, People's Republic of China.
    Background: During weaning, babies and young animal often experience diarrhea from food intolerance and/or decreasing levels of maternal antibodies, and diarrhea tends to be particularly severe during the early-weaned period, which often exhibits an underdeveloped immune system, a disturbed gut environment and results in nutrient malabsorption and dehydration. It was deduced that neuroendocrine might have close relation with diarrhea, especially 5-HT.

    Methods: To explore the role of serotonin (5-HT) in weaning mice subjected to stress-induced diarrhea, 21-day-old weaned mice were divided into the following groups: control group, stress-induced diarrhea group (restrained by binding the hind limbs and intragastric administration of folium sennae with 0. Read More

    Laparoscopic gastrectomy in obese gastric cancer patients: a comparative study with non-obese patients and evaluation of difference in laparoscopic methods.
    BMC Gastroenterol 2017 Jun 19;17(1):78. Epub 2017 Jun 19.
    Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, Zhejiang Province, 310016, China.
    Background: Obesity is a growing epidemic around the world, and obese patients are generally regarded as high risk for surgery compared with normal weight patients. The purpose of this study was to evaluate the influence of obesity on the surgical outcomes of laparoscopic gastrectomy (LG) for gastric cancer.

    Methods: We reviewed data for all patients undergoing LG for gastric cancer at our institute between October 2004 and December 2016. Read More

    Novel NBAS mutations and fever-related recurrent acute liver failure in Chinese children: a retrospective study.
    BMC Gastroenterol 2017 Jun 19;17(1):77. Epub 2017 Jun 19.
    The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
    Background: Underlying causes in Chinese children with recurrent acute liver failure (RALF), including liver crises less than full acute liver failure, are incompletely understood. We sought to address this by searching for genes mutated in such children.

    Methods: Five unrelated Chinese boys presenting between 2012 and 2015 with RALF of unexplained etiology were studied. Read More

    Fetal death in utero and miscarriage in a patient with Crohn's disease under therapy with ustekinumab: case-report and review of the literature.
    BMC Gastroenterol 2017 Jun 19;17(1):80. Epub 2017 Jun 19.
    Department of Gastroenterology, Lyon-Sud hospital, Hospices Civils de Lyon, Université Lyon1, Lyon, France.
    Background: Ustekinumab is a fully human monoclonal antibody against the p40 subunit of interleukin (IL) 12 and 23 which is involved in the pathogenesis of several inflammatory diseases. Ustekinumab is approved for psoriasis and psoriatic arthritis treatment and has been successfully evaluated in phase II and III trials for patients with Crohn's disease (CD).

    Case Presentation: We report here the case of a patient who became pregnant during treatment with ustekinumab for a refractory CD and which ended in miscarriage. Read More

    Polymorphism in asparagine synthetase is associated with overall survival of hepatocellular carcinoma patients.
    BMC Gastroenterol 2017 Jun 19;17(1):79. Epub 2017 Jun 19.
    Department of Hepatobiliary Surgery, Weifang People's Hospital, Weifang, Shandong, 261041, China.
    Background: Recently, it is reported that asparagine synthetase (ASNS) is an independent predictor of surgical survival in hepatocellular carcinoma (HCC) patients. It is also reported that activating transcription factor 6 (ATF6) expression is decreased in HCC patients. So in the present study, we explored the relationship between ASNS and ATF6, and whether ASNS expression was associated with HCC. Read More

    Survivin expression pattern in the intestine of normoxic and ischemic rats.
    BMC Gastroenterol 2017 Jun 14;17(1):76. Epub 2017 Jun 14.
    Institute of Physiological Chemistry, University Hospital Essen, Hufelandstraße 55, D-45147, Essen, Germany.
    Background: Survivin, a member of the inhibitor of apoptosis protein (IAP) family, regulates mitosis and chromosome segregation. The expression of survivin proceeds during embryonic development and in addition has already been demonstrated in cancer cells. However, there is also evidence of survivin expression in differentiated tissues, including the gastro-intestinal tract of adult rats. Read More

    Sclerosing mesenteritis and mesenteric panniculitis - clinical experience and radiological features.
    BMC Gastroenterol 2017 Jun 13;17(1):75. Epub 2017 Jun 13.
    Department of Medicine, Division of Gastroenterology, Hospital of Trelleborg, Trelleborg, Sweden.
    Background: Sclerosing mesenteritis (SM) is sometimes used as an umbrella-term for idiopathic inflammatory conditions in the mesentery. Mesenteric panniculitis (MP) is a radiological finding and its relation to clinical SM is not fully understood. The aims of this study were to determine whether any correlation could be found between the radiological findings and the clinical disease course. Read More

    Alteration of gut microbiota in association with cholesterol gallstone formation in mice.
    BMC Gastroenterol 2017 Jun 9;17(1):74. Epub 2017 Jun 9.
    Institute of Gallstone Disease, Center of Gallbladder Disease, Shanghai East Hospital, Tongji University School of Medicine, #150 Jimo Road, Shanghai, 201200, China.
    Background: The gut microbiome exerts extensive roles in metabolism of nutrients, pharmaceuticals, organic chemicals. Little has been known for the role of gut microbiota in regulating cholesterol and bile acids in association with gallstone formation. This study investigated the changes in the composition of gut microbiota in mice fed with lithogenic diet (LD). Read More

    Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts.
    BMC Gastroenterol 2017 Jun 7;17(1):73. Epub 2017 Jun 7.
    Digestive Disease Center, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam, 463-712, South Korea.
    Background: Intestinal fibrosis is a serious complication of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. There is no specific treatment for intestinal fibrosis. Studies have indicated that peroxisome proliferator-activated receptor- γ (PPAR-γ) agonists have anti-fibrogenic properties in organs besides the gut; however, their effects on human intestinal fibrosis are poorly understood. Read More

    Incomplete ileus and hemafecia as the presenting features of multi-organ involved primary systemic AL amyloidosis: a rare case report.
    BMC Gastroenterol 2017 Jun 5;17(1):72. Epub 2017 Jun 5.
    The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District Changsha, Hunan, 410013, China.
    Background: AL Amyloidosis is known to be a systemic disease affecting multiple organs and tissue while it's rare that patients present with gastrointestinal symptoms at first and later develop multiple-organ dysfuction. Clinical signs are not specific and the diagnosis is rarely given before performing immunofixation and endoscopy with multiple biopsies. We would like to emphasize the value of precise diagnostic process of AL amyloidosis. Read More

    Clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater.
    BMC Gastroenterol 2017 May 31;17(1):70. Epub 2017 May 31.
    Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-Ro, Seo-Gu, Busan, 602-739, South Korea.
    Background: The study aims to investigate the clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater (NETAoVs) patients who underwent pancreaticoduodenectomy.

    Methods: From January 2007 to December 2014, 45 patients underwent pancreaticoduodenectomy for malignant disease of the ampulla of Vater in our institution. Of those, 5 patients were diagnosed as neuroendocrine tumors. Read More

    Optimal timing of cholecystectomy after percutaneous gallbladder drainage for severe cholecystitis.
    BMC Gastroenterol 2017 May 31;17(1):71. Epub 2017 May 31.
    Department of surgery, South Miyagi Medical Center, 38-1 Aza-nishi, Ogawara, Shibata-gun, Miyagi, 989-1253, Japan.
    Background: The Tokyo guideline for acute cholecystitis recommended percutaneous transhepatic gallbladder drainage followed by cholecystectomy for severe acute cholecystitis, but the optimal timing for the subsequent cholecystectomy remains controversial.

    Methods: Sixty-seven patients who underwent either laparoscopic or open cholecystectomy after percutaneous transhepatic gallbladder drainage for severe acute cholecystitis were enrolled and divided into difficult cholecystectomy (group A) and non-difficult cholecystectomy (group B). Patients who had one of these conditions were placed in group A: 1) conversion from laparoscopic to open cholecystectomy; 2) subtotal cholecystectomy and/or mucoclasis; 3) necrotizing cholecystitis or pericholecystic abscess formation; 4) tight adhesions around the gallbladder neck; and 5) unsuccessfully treated using PTGBD. Read More

    Therapeutic outcomes of endoscopic papillectomy for ampullary neoplasms: retrospective analysis of a multicenter study.
    BMC Gastroenterol 2017 May 30;17(1):69. Epub 2017 May 30.
    Department of Internal Medicine, Daegu Fatima Hospital, Daegu, South Korea.
    Background: Endoscopic papillectomy (EP) is reported to be a relatively safe and reliable procedure for complete resection of ampullary neoplasms. The aim of this study was to evaluate the therapeutic outcomes and complications of EP for ampullary neoplasms.

    Methods: A retrospective multicenter study was conducted with 5 participating centers from January 2007 to July 2014. Read More

    Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease.
    BMC Gastroenterol 2017 May 25;17(1):68. Epub 2017 May 25.
    Division of Medical Diagnostics, Region Jönköping County, Jönköping, Sweden.
    Background: Inflammatory bowel disease (IBD) is associated with increased intestinal permeability, which involves paracellular passage regulated through tight junctions (TJ). The aim of the study was to investigate single nucleotide polymorphisms (SNP) located in genes encoding interacting TJ proteins and corresponding expressions, in relation to IBD.

    Methods: Allelic associations between TJ-related genes (F11R, MAGI1, MAGI2, MAGI3, PARD3, PTEN, and TJP1) and IBD, Crohn's disease (CD), or ulcerative colitis (UC) were investigated. Read More

    Comparison of oesophageal function tests between Chinese non-erosive reflux disease and reflux hypersensitivity patients.
    BMC Gastroenterol 2017 May 23;17(1):67. Epub 2017 May 23.
    Digestive Department, Beijing Anzhen Hospital,Capital Medical University, Beijing, 100029, China.
    Background: By means of 24 h multi-channel intraluminal impedance and pH recording (MII/pH), patients with heartburn and normal upper gastrointestinal endoscopy findings can be classified into those with non-erosive reflux disease (NERD) and those with reflux hypersensitivity (RH). Therefore, in this study, we investigated the difference in oesophageal function tests in Chinese patients with NERD and RH.

    Methods: NERD patients were selected from the digestive department, Beijing Anzhen Hospital and Beijing Chao-Yang Hospital, Capital Medical University, after upper gastrointestinal endoscope, high-resolution manometry and impedance (HRiM), and MII/pH examinations between 2014 and 2016. Read More

    Efficacy of chemotherapy in elderly patients with unresectable pancreatic cancer: a multicenter review of 895 patients.
    BMC Gastroenterol 2017 May 22;17(1):66. Epub 2017 May 22.
    Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To-on, Ehime, Japan.
    Background: The efficacy of chemotherapy for unresectable pancreatic cancer has improved. However, it is occasionally difficult to make treatment decisions for elderly patients. We reviewed the outcomes of elderly patients with unresectable pancreatic cancer by using a large cohort and evaluated whether they had received chemotherapy and the reason why. Read More

    Self-rated health and functional capacity in individuals reporting overlapping symptoms of gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome - a population based study.
    BMC Gastroenterol 2017 May 18;17(1):65. Epub 2017 May 18.
    Research Unit of General Practice, Department of Public Health, University of Southern Denmark, J. B. Winsløws Vej 9A, DK-5000, Odense C., Denmark.
    Background: Gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common functional gastrointestinal conditions with a significant impact on daily life. The objectives were to analyse general self-rated health and self-reported functional capacity in adults meeting the criteria for GERD, FD and IBS, respectively, and in individuals who meet the criteria for more than one of the conditions.

    Methods: A nationwide study of 100,000 individuals aged 20 years and above, randomly selected in the general Danish population. Read More

    Predictors of fifty days in-hospital mortality in patients with culture negative neutrocytic ascites.
    BMC Gastroenterol 2017 May 16;17(1):64. Epub 2017 May 16.
    Department of Hepatology, Institute of Liver and Biliary Sciences (ILBS), New Delhi, India.
    Background: Culture negative neutrocytic ascites is a variant of spontaneous bacterial peritonitis. But there are conflicting reports regarding the mortality associated with culture negativeneutrocytic ascites. Therefore we aim to determine the predictors of mortality associated with culture negativeneutrocytic ascites in a larger sample population. Read More

    Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn's disease, and clinical prognosis in inflammatory bowel disease.
    BMC Gastroenterol 2017 May 12;17(1):63. Epub 2017 May 12.
    Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, 90095, USA.
    Background: Cathelicidin (LL-37) is an antimicrobial peptide known to be associated with various autoimmune diseases. We attempt to determine if cathelicidin can accurately reflect IBD disease activity. We hypothesize that serum cathelicidin correlates with mucosal disease activity, stricture, and clinical prognosis of IBD patients. Read More

    Accuracy of M2BPGi, compared with Fibro Scan®, in analysis of liver fibrosis in patients with hepatitis C.
    BMC Gastroenterol 2017 May 10;17(1):62. Epub 2017 May 10.
    Department of Hepatology, First Hospital of Jilin University, Jilin University, Changchun, 130021, China.
    Background: Mac-2 Binding Protein Glycosylation isomer (M2BPGi) is a novel serological glyco-biomarker for staging liver fibrosis. Here, we aimed to evaluate the efficiency of serum M2BPGi in identifying liver fibrosis stages in Chinese patients with chronic hepatitis C infection.

    Methods: Serum M2BPGi levels were evaluated in 680 patients with chronic hepatitis C and 164 healthy controls who underwent the Fibro Scan® test of liver fibrosis. Read More

    Noninvasive assessment of liver steatosis in children: the clinical value of controlled attenuation parameter.
    BMC Gastroenterol 2017 May 4;17(1):61. Epub 2017 May 4.
    Ultrasound Unit, Department of Infectious Diseases, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Viale Camillo Golgi 19, Pavia, 27100, Italy.
    Background: To assess the clinical validity of controlled attenuation parameter (CAP) in the diagnosis of hepatic steatosis in a series of overweight or obese children by using the imperfect gold standard methodology.

    Methods: Consecutive children referred to our institution for auxological evaluation or obesity or minor elective surgery were prospectively enrolled. Anthropometric and biochemical parameters were recorded. Read More

    FBXW7 expression is associated with prognosis and chemotherapeutic outcome in Chinese patients with gastric adenocarcinoma.
    BMC Gastroenterol 2017 May 2;17(1):60. Epub 2017 May 2.
    Department of Gastrointestinal Surgery, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200127, People's Republic of China.
    Background: FBXW7, a component of the Skp-Cullin1-F-box, mediates target protein recognition. It is a tumor suppressor gene that plays a role in the regulation of cell cycle exit and reentry via c-Myc, c-Jun and Notch degradation. There are few studies, particularly involving a large patient cohort, that have evaluated FBXW7 during gastric cancer progression. Read More

    Serum albumin, a good indicator of persistent organ failure in acute pancreatitis.
    BMC Gastroenterol 2017 Apr 26;17(1):59. Epub 2017 Apr 26.
    Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, Hubei Province, People's Republic of China.
    Background: To evaluate the predictive value of serum albumin (ALB) for persistent organ failure (POF) in acute pancreatitis (AP).

    Methods: We selected 158 patients with AP in this retrospective study from Jan.1st, 2015 to Dec. Read More

    Proteinuria and baseline renal function predict mortality and renal outcomes after sirolimus therapy in liver transplantation recipients.
    BMC Gastroenterol 2017 Apr 20;17(1):58. Epub 2017 Apr 20.
    Liver Transplant Center, Department of Surgery, Kaohsiung, Taiwan.
    Background: Chronic kidney disease is a significant complication after liver transplantation (LT), but the role of pre-existing renal insufficiency and proteinuria remains unclear among LT recipients receiving sirolimus.

    Methods: We assessed the effects of proteinuria and baseline renal function on long-term renal and survival outcomes among 576 LT recipients who received SRL in a medical center between 2005 and 2014. Renal outcomes were the incidences of >50% reduction in their baseline estimated glomerular filtration rate and end stage kidney disease requiring renal replacement therapy. Read More

    Cholesterol esterification in plasma as a biomarker for liver function and prediction of mortality.
    BMC Gastroenterol 2017 Apr 20;17(1):57. Epub 2017 Apr 20.
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Paul-List-Str. 13-15, 04103, Leipzig, Germany.
    Background: Advanced stages of liver cirrhosis lead to a dramatically increased mortality. For valid identification of these patients suitable biomarkers are essential. The most important biomarkers for liver function are bilirubin and prothrombin time expressed as International Normalized Ratio (INR). Read More

    Systematic review with network meta-analysis: dual therapy for high-risk bleeding peptic ulcers.
    BMC Gastroenterol 2017 Apr 19;17(1):55. Epub 2017 Apr 19.
    Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Rd, Hangzhou, 310000, Zhejiang, China.
    Background: Adding a second endoscopic therapy to epinephrine injection might improve hemostatic efficacy in patients with high-risk bleeding ulcers but the optimum modality remains unknown. We aimed to estimate the comparative efficacy of different dual endoscopic therapies for the management of bleeding peptic ulcers through random-effects Bayesian network meta-analysis.

    Methods: Different databases were searched for controlled trials comparing dual therapy versus epinephrine monotherapy or epinephrine combined with another second modality until September, 30 2016. Read More

    Findings in young adults at colonoscopy from a hospital service database audit.
    BMC Gastroenterol 2017 Apr 19;17(1):56. Epub 2017 Apr 19.
    Department of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville South 5011, Adelaide, South Australia, Australia.
    Background: Colorectal cancer (CRC) diagnosed at <50 years is predominantly located in the distal colon and rectum. Little is known about which lesion subtypes may serve as CRC precursors in young adults. The aim of this work was to document the prevalence and histological subtype of lesions seen in patients aged <50 years, and any associated clinical features. Read More

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