156,104 results match your criteria BMC Gastroenterology[Journal]
Biomed Chromatogr 2018 Dec 5:e4457. Epub 2018 Dec 5.
Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, PR China.
Angelica sinensis (Danggui, DG) parched with alcohol (Jiu Danggui, JDG) and charred DG (CDG) were main processed products of DG, which were used to treat blood stasis syndrome (BSS). However, their therapeutic effect and mechanisms are still unclear. Based on a rats acute BSS model, the intervention effects of DG and its processed products (DGPPs) were evaluated by the hemorheology and coagulation function parameters. Read More
Biomed Chromatogr 2018 Dec 5:e4454. Epub 2018 Dec 5.
Department of Pharmacy, Shanghai Jiao Tong University Affliated Sixth People's Hospital, Shanghai, P. R. China.
Danhong injection (DHI) is made from Salvia miltiorrhiza Bunge. and Carthamus tinctorius L. extract and is widely used in the clinical treatment of cardiovascular and cerebrovascular diseases. Read More
Biomed Chromatogr 2018 Dec 5:e4458. Epub 2018 Dec 5.
Bioanalytical Department, Alkem Laboratories Ltd., Lower Parel, Mumbai, India.
A highly sensitive, selective and rapid ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed for the quantification of a Janus kinase (JAK) inhibitor, tofacitinib (TOF). The assay employed liquid-liquid extraction with methyl-tert butyl ether to extract tofacitinib and tofacitinib-13C3 15N (as internal standard) from human plasma. The samples were analyzed on UPLC BEH C18 (50 × 2. Read More
BMC Biophys 2018 29;11. Epub 2018 Nov 29.
Department of Biochemistry and Molecular Biology, Campusvej 55, Odense M, 5230 Denmark.
Background: Intracellular phase separation and aggregation of proteins with extended poly-glutamine (polyQ) stretches are hallmarks of various age-associated neurodegenerative diseases. Progress in our understanding of such processes heavily relies on quantitative fluorescence imaging of suitably tagged proteins. Fluorescence loss in photobleaching (FLIP) is particularly well-suited to study the dynamics of protein aggregation in cellular models of Chorea Huntington and other polyQ diseases, as FLIP gives access to the full spatio-temporal profile of intensity changes in the cell geometry. Read More
BMC Nurs 2018 29;17:50. Epub 2018 Nov 29.
School of Nursing, Tung Wah College, 31 Wylie Road, Homantin, Kowloon, Hong Kong.
Background: To adopt a healthy lifestyle is considered an essential component of nursing education. Self-rated health is a subjective assessment of health status and is consistent with objective health status. Previous studies have shown an association between self-rated health and engagement in a healthy lifestyle. Read More
BMC Nurs 2018 29;17:49. Epub 2018 Nov 29.
4School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK.
Background: A changing sociodemographic landscape has seen rising numbers of people with two or more long-term health conditions. Multimorbidity presents numerous challenges for patients and families and those who work in healthcare services. Therefore, the nursing profession needs to understand the issues involved in supporting people with multiple chronic conditions and how to prepare the future workforce to care for them. Read More
BMC Clin Pathol 2018 28;18:13. Epub 2018 Nov 28.
Department of Pathology, Military General Hospital Mohammed V, Mohammed V- Souissi University, Hay Riad, 10000 Rabat, Morocco.
Background: Urinary schistosomiasis is a common parasitic disease in endemic countries.
Case Presentation: We report the case of a patient who was on a working trip to Mauritania. This parasitosis, suspected in the presence of hematuria and the notion of stay in an endemic zone, was confirmed by the presence of Schistosoma heamatobium eggs during the histological examination of the bladder biopsy performed after cystoscopy, highlighting a bilharzial granuloma and of course, the diagnosis was confirmed by the presence of eggs during the direct examination of the freshly collected urine. Read More
BMC Res Notes 2018 Dec 5;11(1):862. Epub 2018 Dec 5.
Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Objectives: Family planning is achieved through use of different contraceptive methods among which the most effective methods are modern family planning methods like long acting reversible contraceptive which includes intra-uterine contraceptive device and Implants. The objective of this primary study was to assess utilization of long acting reversible contraceptive methods among female college students in Gondar town, northwest Ethiopia.
Results: The overall utilization of long acting reversible contraceptive methods among students was 20. Read More
BMC Med Educ 2018 Dec 5;18(1):295. Epub 2018 Dec 5.
Houston Methodist Hospital, Houston, TX, USA.
Background: Operating room (OR) metrics are frequently cited when optimizing cost efficacy and quality of care (Weiss et al, Characteristics of operating room procedures in U.S. hospitals, 2011: Statistical brief #170, 2013; Macario A, Anesthesiology 105:237-240, 2006; Childers et al, JAMA Surg 153:e176233, 2018). Read More
BMC Med 2018 Dec 6;16(1):228. Epub 2018 Dec 6.
Unit of PharmacoTherapy, -Epidemiology & -Economics (PTE2), University of Groningen, Groningen Research Institute of Pharmacy, Groningen, The Netherlands.
Background: The newly registered adjuvanted herpes zoster subunit vaccine (HZ/su) has a higher efficacy than the available live-attenuated vaccine (ZVL). National decision-makers soon need to decide whether to introduce HZ/su or to prefer HZ/su above ZVL.
Methods: Using a Markov model with a decision tree, we conducted a cost-effectiveness analysis of vaccination with HZ/su (two doses within 2 months) or zoster vaccine live (ZVL) (single dose, or single dose with a booster after 10 years) for cohorts of 50-, 60-, 70- or 80-year-olds in the Netherlands. Read More
BMC Res Notes 2018 Dec 5;11(1):865. Epub 2018 Dec 5.
Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA, USA.
Objective: Brucellosis is one of the top five priority zoonosis in Kenya because of the socio-economic burden of the disease, especially among traditional, livestock keeping communities. We conducted a 1 year, hospital based, unmatched case-control study to determine risk factors for brucellosis among Maasai pastoralists of Kajiado County in 2016. A case was defined by a clinical criteria; fever or history of fever and two clinical signs suggestive of brucellosis and a positive competitive enzyme-linked immunosorbent assay test (c-ELISA). Read More
BMC Res Notes 2018 Dec 5;11(1):863. Epub 2018 Dec 5.
Dualsystems Biotech A.G., Grabenstrasse 11a, 8952, Schlieren, Switzerland.
Objective: The advent of ligand-based receptor capture methodologies, allows the identification of unknown receptor candidates for orphan extracellular ligands. However, further target validation can be tedious, laborious and time-consuming. Here, we present a methodology that provides a fast and cost-efficient alternative for candidate target verification on living cells. Read More
BMC Res Notes 2018 Dec 5;11(1):866. Epub 2018 Dec 5.
Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, ON, K1A 0R6, Canada.
Objective: To isolate and characterize novel high-affinity llama single-domain antibodies against human HER2.
Results: We immunized a llama with human HER2, constructed a phage-displayed VH library from the lymphocytes of the animal, and isolated six unique HER2-specific VHs by panning. All six VHs were unique at the amino acid level and were clonally unrelated, as reflected by their distinct CDR3 lengths. Read More
BMC Res Notes 2018 Dec 5;11(1):861. Epub 2018 Dec 5.
Department of Biology, Davidson College, Davidson, USA.
Objective: The purpose of this project was to use an in vivo method to discover riboswitches that are activated by new ligands. We employed phage-assisted continuous evolution (PACE) to evolve new riboswitches in vivo. We started with one translational riboswitch and one transcriptional riboswitch, both of which were activated by theophylline. Read More
BMC Res Notes 2018 Dec 5;11(1):864. Epub 2018 Dec 5.
National Centre for Asbestos Related Diseases, School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia, Australia.
Objective: Pleural effusion (PE) is a common feature of malignant pleural mesothelioma. These effusions typically contain lymphocytes and malignant cells. We postulated that the PE would be a source of lymphocytes for analysis of tumor immune milieu. Read More
BMC Pulm Med 2018 Dec 5;18(1):186. Epub 2018 Dec 5.
Department of Respiratory Medicine, Allergology and Sleep Medicine, General Hospital Nuremberg, Nuremberg, Germany.
Background: There is a lack of robust data about factors predicting continuation (or termination) of positive airway pressure therapy (PAP) for sleep apnea. This analysis of big data from a German homecare provider describes patients treated with PAP, analyzes the therapy termination rate over the first year, and investigates predictive factors for therapy termination.
Methods: Data from a German homecare service provider were analyzed retrospectively. Read More
BMC Pediatr 2018 Dec 5;18(1):383. Epub 2018 Dec 5.
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Background: Vaccination is still one of the most important methods to control and prevent childhood infections including diphtheria and pertussis. This study evaluated the level of diphtheria (DT) and pertussis (PT)-related antibodies among children with pneumonia in Ji'nan, China.
Methods: A total of 484 sera of children from 1 day to 13 years of age were collected from 2014 to 2015 in Ji'nan. Read More
BMC Womens Health 2018 Dec 5;18(1):197. Epub 2018 Dec 5.
Centre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli 15232, Athens, Greece.
Background: Early diagnosis and efficient management of Chronic Endometritis (CE) in patients seeking fertility treatment are two components every practitioner wishes to address. With respect to endometrial restoration, antibiotic treatment appears to perform well. However, regarding the improvement of In Vitro Fertilization (IVF) success rates, literature evidence is inconclusive, and consensus on optimal treatment has yet to be reached. Read More
BMC Complement Altern Med 2018 Dec 5;18(1):321. Epub 2018 Dec 5.
Pharmacology and toxicology department, King Saud University, Riyadh, Saudi Arabia.
Background: Eugenol is a natural phenolic compound and possesses anticancer and antibacterial activities. Breast cancer is a major global health problem, and most of the chemotherapeutic agents are highly toxic with long-term side effects. Therefore, this study aimed to explore the possibility of using eugenol as an anti-metastatic and anti-proliferative agent against MDA-MB-231 and SK-BR-3 breast cancer cells. Read More
BMC Womens Health 2018 Dec 5;18(1):198. Epub 2018 Dec 5.
Mothers and Babies Research Centre, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.
Background: Despite efforts at curbing maternal morbidity and mortality, developing countries are still burdened with high rates of maternal morbidity and mortality. Ethiopia is not an exception and has one of the world's highest rates of maternal deaths. Reducing the huge burden of maternal mortality remains the single most serious challenge in Ethiopia. Read More
BMC Complement Altern Med 2018 Dec 5;18(1):323. Epub 2018 Dec 5.
Institute of Nutrition, China Medical University, Taichung, 40402, Taiwan.
Background: Weight reduction frequently occurs in patients receiving vagus nerve stimulation (VNS) therapy. Therefore, we hypothesized that during dietary intervention for weight loss, auricular electric stimulation (AES), an alternative of VNS, accelerates weight loss by increasing white adipose tissue (WAT) browning and increases energy expenditure.
Methods: C57BL/6J male mice were fed a high-fat diet for 5 wk. Read More
BMC Complement Altern Med 2018 Dec 5;18(1):324. Epub 2018 Dec 5.
Department of Physiology School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
Background: This study assessed the effects of propolis alone or combined with insulin on maternal status, pregnancy outcomes and placental oxidative stress in streptozotocin-induced diabetic rats.
Methods: Forty female rats were randomly assigned into five groups (n = 8/group) i.e. Read More
BMC Vet Res 2018 Dec 5;14(1):387. Epub 2018 Dec 5.
Department of Veterinary Science, University of Turin, Largo Paolo Braccini, 2 10095 Grugliasco, Turin, Italy.
Background: The aim of the present study was to assess the reliability of a new strategy for monitoring the serological response against Bovine Herpesvirus 1 (BoHV1), the causative agent of infectious bovine rhinotracheitis (IBR). Bulk milk samples have already been identified as cost effective diagnostic matrices for monitoring purposes. Nevertheless, most eradication programs are still based on individual standard assays. Read More
BMC Health Serv Res 2018 Dec 5;18(1):945. Epub 2018 Dec 5.
Centre For Population Health, Burnet Institute, 85 Commercial Road, Melbourne, VIC, 3004, Australia.
Background: Drug overdose is a leading cause of mortality and morbidity amongst people who inject drugs (PWID). Drug overdose surveillance typically relies on the International Classification of Diseases (ICD-10) coding system, however its real world utilisation and the implications for surveillance have not been well characterised. This study examines the patterns of ICD-10 coding pertaining to drug overdoses within emergency departments for a cohort of known PWID. Read More
BMC Vet Res 2018 Dec 5;14(1):386. Epub 2018 Dec 5.
Memphis Veterinary Specialists, 555 Trinity Creek Cove, Cordova, TN, 38018, USA.
Background: Internal plate fixation and, more recently, locking plate fixation are commonly used in the repair of fractures in small animal surgery. This retrospective study reviewed the use of the String of Pearls locking plate system in the fixation/repair of appendicular long bone skeleton fractures in 31 small animal veterinary patients (33 fractures).
Results: Major complications necessitating revision surgery occurred in 7/33 (21%), with implant failure as the inciting cause in all cases. Read More
BMC Complement Altern Med 2018 Dec 5;18(1):320. Epub 2018 Dec 5.
Herbal Medicine Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia.
Background: Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to dengue pathogenesis such as nonstructural protein 1 (NS1) production and viremia level have never been highlighted in any clinical and in vivo studies. The aim of this study is to investigate the effect of freeze-dried CPLJ treatment on NS1 and viremia levels of dengue fever mouse model. Read More
BMC Ecol 2018 Dec 5;18(1):56. Epub 2018 Dec 5.
Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Avinguda Diagonal 643, 08028, Barcelona, Spain.
Background: Identifying the factors that affect ranging behavior of animals is a central issue to ecology and an essential tool for designing effective conservation policies. This knowledge provides the information needed to predict the consequences of land-use change on species habitat use, especially in areas subject to major habitat transformations, such as agricultural landscapes. We evaluate inter-individual variation relative to environmental predictors and spatial constraints in limiting ranging behavior of female little bustards (Tetrax tetrax) in the non-breeding season. Read More
BMC Public Health 2018 Dec 5;18(1):1345. Epub 2018 Dec 5.
SRM Institute of Gastroenterology, Hepatobiliary Sciences & Transplantation, SIMS Hospital, Jawaharlal Nehru Road, Vadapalani, Chennai, Tamil Nadu, India.
Background: Vitamin D has multifarious roles in maintenance of health and prevention of disease. The present study was undertaken to assess the vitamin D status of a rural adult south Indian population and to identify its associations with socioeconomic status and cultural practices.
Methods: Between June 2015 and July 2016, 424 healthy adults residing in Kattankulathur block in Tamil Nadu, India, provided venous blood samples and answered questions by personal interview. Read More
BMC Health Serv Res 2018 Dec 5;18(1):944. Epub 2018 Dec 5.
National Institute for Medical Research (NIMR)-Headquarters, PO Box 9356, Dar-es-Salaam, Tanzania.
Background: The Lake and Western Zones of Tanzania that encompass eight regions namely; Kagera, Geita, Simiyu, Shinyanga, Mwanza, Mara Tabora and Kigoma have consistently been reported with the poorest Maternal Newborn and Child Health (MNCH) indicators in the country. This study sought to establish the provision of Emergency Obstetric Care (EmOC) signal functions and reasons for the failure to do so among health centers and hospitals in the two zones.
Methods: All the 261 public and private hospitals and health centers providing Obstetric Care services in Lake and Western Zones were surveyed in 2014. Read More
BMC Vet Res 2018 Dec 5;14(1):385. Epub 2018 Dec 5.
Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Jiangsu Co-innovation Center for Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Background: Enterotoxigenic Escherichia coli (ETEC) causes diarrhea in humans, cows, and pigs. The gut microbiota underlies pathology of several infectious diseases yet the role of the gut microbiota in the pathogenesis of ETEC-induced diarrhea is unknown.
Results: By using an ETEC induced diarrheal model in piglet, we profiled the jejunal and fecal microbiota using metagenomics and 16S rRNA sequencing. Read More
BMC Public Health 2018 Dec 5;18(1):1347. Epub 2018 Dec 5.
Centre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Background: Across most high-income countries, populations are ageing. With this demographic change is an increase in the number of people living with disabilities. In this context, we sought to examine the prevalence of disability discrimination and disability avoidance in Australia, the demographic and health correlates of exclusion and the contexts in which disability discrimination and avoidance are experienced. Read More
BMC Complement Altern Med 2018 Dec 5;18(1):322. Epub 2018 Dec 5.
Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, 94710, USA.
Background: Human infection by pathogenic Salmonella bacteria can be acquired by consuming of undercooked meat products and eggs. Antimicrobial resistance against antibiotics used in medicine is also a major concern. To help overcome these harmful effects on microbial food safety and human health, we are developing novel antimicrobial food-compatible formulations, one of which is described in the present study. Read More
BMC Psychiatry 2018 Dec 5;18(1):381. Epub 2018 Dec 5.
Department of Population Health, New York University School of Medicine, New York, USA.
Background: Adverse childhood experiences (ACEs) is a significant public health and social welfare problem in low-and middle income countries (LMICs). However, most ACEs research is based on developed countries, and little is known about mechanisms of early ACEs on adulthood health and offspring's wellbeing for populations in LMICs. This area is needed to guide social welfare policy and intervention service planning. Read More
BMC Med Educ 2018 Dec 5;18(1):296. Epub 2018 Dec 5.
Department of Health and Caring Sciences, University of Gävle, Gävle, Sweden.
Background: The Swedish healthcare system has an increased need for nurses and physicians, and the number of International Educated Nurses (IENs) and International Medical Graduates (IMGs) seeking job opportunities and a license to practice in Sweden is rising. This study explored how IENs and IMGs describe their experience of getting a license to practice, their perceptions of working in Sweden and of how their intercultural competence is utilized.
Method: A qualitative study based on semi-structured interviews with 11 IENs and 11 IMGs. Read More
BMC Oral Health 2018 Dec 5;18(1):203. Epub 2018 Dec 5.
Department of Endodontics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830054, China.
Background: In recent years, the opportunistic fungus C.albicans has been linked to ECC.It is important to investigate the relationship between the distribution of C. Read More
BMC Public Health 2018 Dec 5;18(1):1344. Epub 2018 Dec 5.
Public Health Ontario, 480 University Avenue, Suite 300, Toronto, ON, M5G 1V2, Canada.
Background: Emergencies and disasters impact population health. Despite the importance of upstream readiness, a persistent challenge for public health practitioners is defining what it means to be prepared. There is a knowledge gap in that existing frameworks lack consideration for complexity relevant to health systems and the emergency context. Read More
BMC Surg 2018 Dec 5;18(1):113. Epub 2018 Dec 5.
Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Background: Synovial cyst of the hip joint is a rare clinical condition in need of evidence-based guidelines for its diagnosis and management. Normally, synovial cyst of the hip joint requires no treatment, but when it intrudes into surrounding structures, various clinical symptoms appear. Because of its rarity, a symptomatic synovial cyst is often confounded with a tumor as a space-occupying lesion or with other diseases, depending on its various clinical presentations. Read More
BMC Public Health 2018 Dec 5;18(1):1346. Epub 2018 Dec 5.
Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard Health Affairs (MNGHA), Riyadh, Kingdom of Saudi Arabia.
Background: Dehydration results from a decrease in total body water content either due to less intake or more fluid loss. Common symptoms of dehydration are dry mouth/tongue, thirst, headache, and lethargy. The aim of this study was to assess knowledge of dehydration definition, symptoms, causes, prevention, water intake recommendations and water intake practices among people living in Riyadh, Saudi Arabia. Read More
BMC Palliat Care 2018 Dec 5;17(1):127. Epub 2018 Dec 5.
Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Background: Patients who engage in Advance Care Planning (ACP) are more likely to get care consistent with their values. We sought to determine the barriers and facilitators to ACP engagement after discharge from hospital.
Methods: Prior to discharge from hospital eligible patients received a standardized conversation about prognosis and ACP. Read More
BMC Med Res Methodol 2018 Dec 5;18(1):163. Epub 2018 Dec 5.
Pusat Citra Universiti, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.
Background: The demand in biobanking for the collection and maintenance of biological specimens and personal data from civilians to improve the prevention, diagnosis and treatment of diseases has increased notably. Despite the advancement, certain issues, specifically those related to privacy and data protection, have been critically discussed. The purposes of this study are to assess the willingness of stakeholders to participate in biobanking and to determine its predictors. Read More
BMC Gastroenterol 2018 Dec 5;18(1):182. Epub 2018 Dec 5.
Department of Gastroenterology, Gongli Hospital, The Second Military Medical University, Shanghai, China.
Background: Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. Read More
BMC Plant Biol 2018 Dec 5;18(1):333. Epub 2018 Dec 5.
IRD, Laboratoire des Symbioses Tropicales et Méditerranéennes, UMR LSTM, Campus International de Baillarguet, 34398, Montpellier, France.
Background: Among semi-aquatic species of the legume genus Aeschynomene, some have the property of being nodulated by photosynthetic Bradyrhizobium lacking the nodABC genes necessary for the synthesis of Nod factors. Knowledge of the specificities underlying this Nod-independent symbiosis has been gained from the model legume Aeschynomene evenia but our understanding remains limited due to the lack of comparative genetics with related taxa using a Nod factor-dependent process. To fill this gap, we combined different approaches to perform a thorough comparative analysis in the genus Aeschynomene. Read More
BMC Pregnancy Childbirth 2018 Dec 5;18(1):478. Epub 2018 Dec 5.
c/- Te Kupenga Hauora Māori, Medical and Health Sciences, University of Auckland, 261 Morrin Rd, Glen Innes, Auckland, 1072, New Zealand.
Background: Although early detection and management of excess rates of gestational diabetes mellitus (GDM) among Indigenous women can substantially reduce maternal and offspring complications, current interventions seem ineffective for Indigenous women. While undertaking a qualitative study in a rural community in Northland, New Zealand about the complexities of living with diabetes, we observed a common emotional discourse about the burden of diabetic pregnancies. Given the significance of GDM and our commitment to give voice to Indigenous Māori women in ways that could potentially inform solutions, we aimed to explore the phenomenon of GDM among Māori women in a rural context marked by high area-deprivation. Read More
BMC Cancer 2018 Dec 5;18(1):1220. Epub 2018 Dec 5.
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Background: Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression and promoted cancer progression through various mechanisms. However, the prognostic value of MDSCs in cancer remains controversial. Read More
BMC Infect Dis 2018 Dec 5;18(1):623. Epub 2018 Dec 5.
School of Veterinary Science, Faculty of Science, University of Sydney, Camperdown, New South Wales, Australia.
Background: Salmonella is an important human pathogen in Australia and annual case rates continue to increase. In addition to foodborne exposures, cases have been associated with animal and contaminated environment contact. However, routine surveillance in Australia has tended to focus on humans and food, with no reported attempts to collate and compare Salmonella data from a wider range of potential sources of exposure. Read More
BMC Cardiovasc Disord 2018 Dec 5;18(1):224. Epub 2018 Dec 5.
Department of Cardiology, Nihon University Hospital, 1-6 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8309, Japan.
Background: Lecithin-cholesterol acyltransferase (LCAT) is believed to be involved in reverse cholesterol transport, which is known to play a key role in suppression of atherosclerosis. However, recent investigations have demonstrated that higher LCAT activity, measured in terms of the serum cholesterol esterification rate by an endogenous substrate method, is associated with increased formation of triglyceride (TG)-rich lipoproteins (TRLs), leading to a decrease in the low-density lipoprotein (LDL) particle size. The purpose of this hospital-based longitudinal study was to clarify the causal relationship between changes in the LCAT activity and changes in the LDL-particle size. Read More
BMC Infect Dis 2018 Dec 5;18(1):625. Epub 2018 Dec 5.
Meta Research, Evidera, Bethesda, MD, USA.
Background: Temporal relationships between the time to appropriate antibiotic therapy and outcomes are not well described.
Methods: A systematic literature review and meta-analysis was performed to examine this relationship in patients hospitalized with Klebsiella pneumoniae or Escherichia coli infections.
Results: Twenty identified studies contained data for patients who received delayed appropriate therapy (DAT) versus appropriate antibiotic therapy for these pathogens. Read More
BMC Emerg Med 2018 Dec 5;18(1):52. Epub 2018 Dec 5.
School of Medicine and Surgery, University of Milan-Bicocca, Via Cadore 48, 20900, Monza, MB, Italy.
Background: Secondary insults (SI), such as hypotension, hypoxia, and intracranial hypertension frequently occur after traumatic brain injury (TBI), and have a strong impact on patients' clinical outcomes. The aim of this study is to examine the trajectories of SI from the early phase of injury in the prehospital setting to hospital admission in a cohort of TBI patients.
Methods: This is a retrospective, observational, single centre study on consecutive patients admitted from 1997 to 2016 to the Neuro Intensive Care Unit (NICU) at San Gerardo Hospital, in Monza, Italy. Read More
BMC Med Res Methodol 2018 Dec 5;18(1):164. Epub 2018 Dec 5.
Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.
Objective: The SCL-90 and the SCL-90-R are the most applied measures regarding psychological distress. To reduce and prevent an overload to of the individuals, the Brief Symptom Inventory with 18 items (BSI-18) was developed based on the SCL-90. Since psychological disorders more frequently occur at an older age, there is a growing need for efficient instruments to measure distress in the elderly. Read More
BMC Infect Dis 2018 Dec 5;18(1):626. Epub 2018 Dec 5.
University Medical Centre Utrecht, University of Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.
Background: Febrile Urinary Tract Infection (FUTI) is frequently treated initially with intravenous antibiotics, followed by oral antibiotics guided by clinical response and bacterial susceptibility patterns. Due to increasing infection rates with multiresistant Enterobacteriaceae, antibiotic options for stepdown treatment decline and patients more frequently require continued intravenous antibiotic treatment for FUTI. Fosfomycin is an antibiotic with high bactericidal activity against Escherichia coli and current resistance rates are low in most countries. Read More