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    1848 results match your criteria BMC Gastroenterology[Journal]

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    Jaundice caused by protrusion of a hepatic cyst into common bile duct that was resolved by choledochoscopic needle-knife electrotomy: a case report.
    BMC Gastroenterol 2018 Jun 19;18(1):90. Epub 2018 Jun 19.
    Cholelithiasis Center, East Hospital of Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China.
    Backgroud: Hepatic cysts are the most frequent, innocuous, space-occupying lesions of the liver. The majority of solitary liver cysts are nonsymptomatic. When liver cysts reach a large size, there are some complications, including infection, rupture, spontaneous hemorrhage, obstructive jaundice, and neoplastic degeneration. Read More

    Successful treatment of oral Crohn's disease by anti-TNF-alpha dose escalation - a case report.
    BMC Gastroenterol 2018 Jun 18;18(1):88. Epub 2018 Jun 18.
    Department of Medicine B for Gastroenterology and Hepatology, University Hospital Münster, Albert-Schweitzer-Campus 1, D-48149, Münster, Germany.
    Background: Crohn's Disease (CD) is typically characterized by abdominal symptoms, however, besides gastrointestinal symptoms, CD patients may suffer from extraintestinal manifestations which are far less common and medical treatment can be challenging.

    Case Presentation: We report about a 34-year-old Crohn's Disease (CD) patient in clinical remission under adalimumab therapy who presented in the clinic for Cranio-Maxillo Surgery due to severe pain in the mandibular area. Ulcerative lesions of the buccal-side mucosa of the right mandible were detected. Read More

    Significantly different clinical features between hypertriglyceridemia and biliary acute pancreatitis: a retrospective study of 730 patients from a tertiary center.
    BMC Gastroenterol 2018 Jun 19;18(1):89. Epub 2018 Jun 19.
    Surgical Intensive Care Unit (SICU), Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
    Background: Unlike western world, gallstones and hypertriglyceridemia (HTG) are among the first two etiologies of acute pancreatitis (AP) in China. But yet, detailed differences in clinical features and outcomes between hypertriglyceridemia and biliary acute pancreatitis have not been well described.

    Methods: This retrospective study enrolled 730 acute pancreatitis patients from July 1, 2013 to October 1, 2016 in Jinling Hospital. Read More

    The prevalence and phenotype in Brazilian patients with inflammatory bowel disease.
    BMC Gastroenterol 2018 Jun 18;18(1):87. Epub 2018 Jun 18.
    Departament of Medicine, Federal University and University Hospital Cassiano Antonio Moraes of Espírito Santo, Av. Marechal Campos, 1468, Vitória, ES, 29042-755, Brazil.
    Background: The epidemiology of inflammatory bowel disease (IBD) varies in different countries. This study aimed to assess phenotype, medications, prevalence and incidence of IBD in the State of Espírito Santo, Brazil.

    Methods: Patients with IBD who utilized the Public Medication-Dispensing System of the Department of Health of Espírito Santo, between August 2012 and July 2014. Read More

    Effect of administration of a probiotic preparation on gut microbiota and immune response in healthy women in India: an open-label, single-arm pilot study.
    BMC Gastroenterol 2018 Jun 15;18(1):85. Epub 2018 Jun 15.
    Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.
    Background: Probiotics have been shown to be useful for the treatment of many disease conditions. These beneficial effects are believed to be mediated by change in the composition of gut microbiota and modulation of the host immune responses. However, the available data on the effect of probiotics on these parameters are quite limited. Read More

    Fecal carriage of multidrug-resistant Escherichia coli by community children in southern Taiwan.
    BMC Gastroenterol 2018 Jun 15;18(1):86. Epub 2018 Jun 15.
    Department of Pediatrics, Kaohsiung Veterans General Hospital, No. 386, Ta-Chung 1st Road, Kaohsiung, 81362, Taiwan.
    Background: The emergence of multidrug-resistant (MDR) Escherichia coli (E. coli), particularly E. coli sequence type ST131, is becoming a global concern. Read More

    Additional hepatic Ho-radioembolization in patients with neuroendocrine tumours treated with Lu-DOTATATE; a single center, interventional, non-randomized, non-comparative, open label, phase II study (HEPAR PLUS trial).
    BMC Gastroenterol 2018 Jun 15;18(1):84. Epub 2018 Jun 15.
    Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, the Netherlands.
    Background: Neuroendocrine tumours (NET) consist of a heterogeneous group of neoplasms with various organs of origin. At diagnosis 21% of the patients with a Grade 1 NET and 30% with a Grade 2 NET have distant metastases. Treatment with peptide receptor radionuclide therapy (PRRT) shows a high objective response rate and long median survival after treatment. Read More

    An unusual diverticulum adjacent to two large colonic polyps; a case report.
    BMC Gastroenterol 2018 Jun 14;18(1):83. Epub 2018 Jun 14.
    Department of Gastroenterology, Sheffield Teaching Hospitals, Northern General Hospital, Herries Road, Sheffield, S5 7AU, England.
    Background: Adenocarcinomas can arise in a variety of circumstances in which intestinal segments have been used for urinary diversions. Whereas ureterosigmoidostomy is the oldest and simplest form of continent urinary diversion it also seems to be the most dangerous in this regard. Herein we present a case of colonic neoplasia complicating a non-functioning ureterosigmoidostomy after 55 years; the longest latent period documented to date. Read More

    Obesity increases the risk of erosive esophagitis but metabolic unhealthiness alone does not: a large-scale cross-sectional study.
    BMC Gastroenterol 2018 Jun 8;18(1):82. Epub 2018 Jun 8.
    Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.
    Background: Obesity is a known risk factor for erosive esophagitis (EE) and metabolic unhealthiness has been implicated in EE pathogenesis. However, obesity and metabolic unhealthiness are not synonymous and the associations between obesity, metabolic health, and EE are unclear. Therefore, our aim was to investigate the relationship between EE, obesity, and metabolic health. Read More

    Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma.
    BMC Gastroenterol 2018 Jun 8;18(1):81. Epub 2018 Jun 8.
    Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710000, Shaanxi, China.
    Background: Gastric carcinoma is a malignant disease, and gastric adenocarcinoma (GAC) is the most common histological type. Molecular profiling of GAC has been extensively performed, but few have focused on the clinical significance of gene clusters of the cell cycle.

    Methods: We investigated the genetic profile of cell-cycle-associated genes in a GAC cohort. Read More

    The early outcomes of candidates with portopulmonary hypertension after liver transplantation.
    BMC Gastroenterol 2018 Jun 7;18(1):79. Epub 2018 Jun 7.
    Organ Transplant Center, the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan 2nd Road, Guangzhou, 510080, China.
    Background: Portopulmonary hypertension (PPH) was once regarded as a contraindicaton to liver transplantation (LT). However, growing evidence has indicated that PPH patients undergoing LT may show similar outcomes compared to those without PPH, and researchers have recommended it not be an absolute contraindication. Given this controversy, we aimed to identify and review the current evidence on this topic and to provide a comparison of the outcomes after LT between candidates with PPH and those without. Read More

    Endoscopic submucosal dissection under general anesthesia for superficial esophageal squamous cell carcinoma is associated with better clinical outcomes.
    BMC Gastroenterol 2018 Jun 7;18(1):80. Epub 2018 Jun 7.
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
    Background: Endoscopic submucosal dissection (ESD) has been widely accepted for treating superficial esophageal squamous cell carcinoma (SESCC). The aim of this study was to evaluate the efficacy and safety of ESD for SESCC and the effect of different sedation methods on their clinical outcomes.

    Methods: We retrospectively analyzed a total of 169 patients (175 lesions) who underwent ESD for SESCC at Samsung Medical Center, Seoul, South Korea. Read More

    Hepcidin levels correlate to liver iron content, but not steatohepatitis, in non-alcoholic fatty liver disease.
    BMC Gastroenterol 2018 Jun 5;18(1):78. Epub 2018 Jun 5.
    Unit of Liver Diseases, Department of Upper GI, C1-77 Huddinge, Karolinska University Hospital, Karolinska Institutet, 141 86, Stockholm, Sweden.
    Background: One-third of patients with non-alcoholic fatty liver disease (NAFLD) develop dysmetabolic iron overload syndrome (DIOS), the pathogenesis of which is unknown. Altered production of the iron-regulatory peptide hepcidin has been reported in NAFLD, but it is unclear if this is related to iron accumulation, lipid status or steatohepatitis.

    Methods: Eighty-four patients with liver disease, 54 of which had iron overload, underwent liver biopsy (n = 66) and/or magnetic resonance imaging (n = 35) for liver iron content determination. Read More

    Response of fibroblast growth factor 19 and bile acid synthesis after a body weight-adjusted oral fat tolerance test in overweight and obese NAFLD patients: a non-randomized controlled pilot trial.
    BMC Gastroenterol 2018 Jun 4;18(1):76. Epub 2018 Jun 4.
    Department of Medicine II, Saarland University Medical Center, Saarland University, 66421, Homburg, Germany.
    Background: Non-alcoholic fatty liver disease (NAFLD) is common both in obese and overweight patients. Fibroblast growth factor 19 (FGF19), an intestinal hormone, could play a role in the complex pathogenesis of NAFLD. The aim of our study was to investigate responses of FGF19 and bile acid (BA) synthesis after a body weight-adjusted oral fat tolerance test (OFTT) in overweight and obese NAFLD patients. Read More

    Clinical outcomes of endoscopic mucosal resection for rectal neuroendocrine tumor.
    BMC Gastroenterol 2018 Jun 5;18(1):77. Epub 2018 Jun 5.
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Chongno-gu, Seoul, 03080, Republic of Korea.
    Background: The incidence of rectal neuroendocrine tumors (NETs) is rapidly increasing because of the frequent use of endoscopic screening for colorectal cancers. However, the clinical outcomes of endoscopic resection for rectal NETs are still unclear. The aim of this study was to assess the rates of histologically complete resection (H-CR) and recurrence after endoscopic mucosal resection (EMR) for rectal NETs. Read More

    Therapy susceptible germline-related BRCA 1-mutation in a case of metastasized mixed adeno-neuroendocrine carcinoma (MANEC) of the small bowel.
    BMC Gastroenterol 2018 May 31;18(1):75. Epub 2018 May 31.
    Institute of Pathology, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
    Background: Adenocarcinomas or combined adeno-neuroendocrine carcinomas (MANEC) of small bowel usually have a dismal prognosis with limited systemic therapy options. This is the first description of a patient showing a germline-related BRCA1 mutated MANEC of his ileum. The tumor presented a susceptibility to a combined chemotherapy and the PARP1-inhibitor olaparib. Read More

    Invasive inflammatory fibroid polyp of the stomach: a case report and literature review.
    BMC Gastroenterol 2018 May 31;18(1):74. Epub 2018 May 31.
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
    Background: Inflammatory fibroid polyps (IFPs) are rare mesenchymal lesions that affect the gastrointestinal tract. IFPs are generally considered benign, noninvasive lesions; however, we report a case of an invasive gastric IFP. To the best of our knowledge, this is only the second case report of an invasive gastric IFP. Read More

    Variable Endoscopist performance in proximal and distal adenoma detection during colonoscopy: a retrospective cohort study.
    BMC Gastroenterol 2018 May 30;18(1):73. Epub 2018 May 30.
    Department of Medicine, The University of Ottawa, Ottawa, Canada.
    Background: Adenoma Detection Rate (ADR) is a validated colonoscopy quality indicator. In addition to overall ADR, Distal and Proximal Adenoma Detection Rates may provide important colonoscopy quality information. The goal of this study is to determine the association between distal and proximal adenoma detection (AD) and to identify factors contributing to overall, distal, and proximal AD. Read More

    "Appropriateness of colonoscopy according to EPAGE II in a low resource setting: a cross sectional study from Sri Lanka".
    BMC Gastroenterol 2018 May 29;18(1):72. Epub 2018 May 29.
    National Cancer Control Programme, No.555, Public Health Building Complex, Elvitigala Mawatha, Colombo, 5, Sri Lanka.
    Background: Due to finite resources, the clinical decision to subject a patient to colonoscopy needs to be based on the evidence, regardless of its availability, affordability and safety. This study assessed the appropriateness of colonoscopies conducted in selected study settings in Sri Lanka. In the absence of local guidelines, audit was based on European Panel on Appropriateness of Gastrointestinal Endoscopy II (EPAGE II) criteria. Read More

    A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome.
    BMC Gastroenterol 2018 May 25;18(1):71. Epub 2018 May 25.
    Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
    Background: Accumulating evidence supports the view that an imbalance of gut bacteria contributes to IBS, and that increasing the mass of beneficial species may reduce the numbers of pathogenic bacteria and help alleviate symptoms.

    Methods: In this double-blind trial 400 adult patients with moderate-to-severe symptomatic diarrhea-predominant IBS (IBS-D) were randomized to treatment with the multi-strain probiotic Bio-Kult® (14 different bacterial strains) or placebo for 16 weeks. The change in severity and frequency of abdominal pain was the primary outcome measure. Read More

    HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation.
    BMC Gastroenterol 2018 May 24;18(1):70. Epub 2018 May 24.
    Children's hospital, Damascus, Syria.
    Background: Celiac disease (CD) is a common autoimmune disease in Syria which manifesting with inflammation of the small intestine and with various extra intestinal symptoms. The disease is associated with human HLA-DQ genes encoding HLA-DQ2 and DQ8 proteins.

    Methods: In this study, 49 children patients of CD and 58 healthy control samples were genotyped for HLA-DQ genes using SSP-PCR technique. Read More

    Sustained efficacy following resolution of frequent heartburn with an over-the-counter regimen of esomeprazole 20 mg or placebo for 14 days: two randomized trials.
    BMC Gastroenterol 2018 May 22;18(1):69. Epub 2018 May 22.
    Former Senior Director, Global R&D, Pfizer Consumer Healthcare, Madison, NJ, 07940, USA.
    Background: A two-week course of therapy with an over-the-counter proton-pump inhibitor (PPI) is recommended for frequent heartburn. Limited research has been conducted on the sustained efficacy of short-term PPI therapy after treatment cessation. Esomeprazole 20 mg was evaluated in the seven-day follow-up period after the two-week treatment period using pooled data from two identical randomized, double-blind, placebo-controlled studies. Read More

    Recurrent esophageal stricture from previous caustic ingestion treated with 40-year self-dilation: case report and review of literature.
    BMC Gastroenterol 2018 May 22;18(1):68. Epub 2018 May 22.
    Department of Cardiothoracic Sciences - University of Campania "Luigi Vanvitelli", Via Sergio Pansini 5, 80131, Naples, Italy.
    Background: Corrosive esophageal strictures are common. The severity of the strictures depends on type, quantity, duration of contact and concentration of the caustic substance ingested. Endoscopic balloon dilation and endoscopic bougienage are a cornerstone in the management of the benign esophageal strictures and are the most widely used treatments, but are expensive and invasive procedures. Read More

    Length of Barrett's segment predicts failure of eradication in radiofrequency ablation for Barrett's esophagus: a retrospective cohort study.
    BMC Gastroenterol 2018 May 21;18(1):67. Epub 2018 May 21.
    Department of Gastroenterology and Hepatology, University of Alabama at Birmingham, 1720 2nd Avenue South, BDB 380, Birmingham, AL, 35294, USA.
    Background: We aim to investigate factors that may contribute to failure of eradication of dysplastic Barrett's Esophagus among patients undergoing radiofrequency ablation treatment.

    Methods: A retrospective review of patients undergoing radiofrequency ablation for treatment of Barrett's Esophagus was performed. Data analyzed included patient demographics, medical history, length of Barrett's Esophagus, number of radiofrequency ablation sessions, and histopathology. Read More

    Mitotic and apoptotic activity in colorectal neoplasia.
    BMC Gastroenterol 2018 May 18;18(1):65. Epub 2018 May 18.
    Charles University, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, 2nd Department of Internal Medicine - Gastroenterology, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.
    Background: Colorectal cancer (CRC) is third most commonly diagnosed cancer worldwide. The aim of the prospective study was to evaluate mitosis and apoptosis of epithelial cells at each stage of colorectal neoplasia.

    Methods: A total of 61 persons were enrolled into the study: 18 patients with non-advanced colorectal adenoma (non-a-A), 13 patients with advanced colorectal adenoma (a-A), 13 patients with CRC and 17 controls: individuals with normal findings on colonoscopy. Read More

    Contributions of HLA haplotypes, IL8 level and Toxoplasma gondii infection in defining celiac disease's phenotypes.
    BMC Gastroenterol 2018 May 18;18(1):66. Epub 2018 May 18.
    Celiac Disease Department, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: It is not clear why some patients with coeliac disease (CD) present with severe symptoms and small intestinal mucosal damages while others present with milder symptoms and no frank enteropathy. There is no study to assess the associated factors with mild/severe symptoms and enteropathy. The terminologies like latent, silent and potential are difficult to use and are unrepresentative. Read More

    Case report on pathogenetic link between gluten and IgA nephropathy.
    BMC Gastroenterol 2018 May 16;18(1):64. Epub 2018 May 16.
    Department of Clinical and Experimental Medicine, Unit of Nephrology and Dialysis, University of Messina, Messina, Italy.
    Background: A relationship between IgA nephropathy (IgAN) and celiac disease (CD) has been reported. We show the pathogenetic link for the first time.

    Case Presentation: A 39-year-old man with cystic fibrosis (CF) and CF-related diabetes started to present gross hematuria, back pain and headache. Read More

    Immune monitoring after pediatric liver transplantation - the prospective ChilSFree cohort study.
    BMC Gastroenterol 2018 May 16;18(1):63. Epub 2018 May 16.
    Division of Paediatric Gastroenterology and Hepatology, Department of Paediatric Liver, Kidney and Metabolic Diseases, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
    Background: Although trough levels of immunosuppressive drugs are largely used to monitor immunosuppressive therapy after solid organ transplantation, there is still no established tool that allows for a validated assessment of functional degree of immunosuppression or the identification of clinically relevant over- or under-immunosuppression, depending on graft homeostasis. Reliable non-invasive markers to predict biopsy proven acute rejection (BPAR) do not exist. Literature data suggest that longitudinal measurements of immune markers might be predictive of BPAR, but data in children are scarce. Read More

    A subclinical high tricuspid regurgitation pressure gradient independent of the mean pulmonary artery pressure is a risk factor for the survival after living donor liver transplantation.
    BMC Gastroenterol 2018 May 15;18(1):62. Epub 2018 May 15.
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
    Background: Portopulmonary hypertension (POPH) is characterized by pulmonary vasoconstriction, while hepatopulmonary syndrome (HPS) is characterized by vasodilation. Definite POPH is a risk factor for the survival after orthotopic liver transplantation (OLT), as the congestive pressure affects the grafted liver, while subclinical pulmonary hypertension (PH) has been acknowledged as a non-risk factor for deceased donor OLT. Given that PH measurement requires cardiac catheterization, the tricuspid regurgitation pressure gradient (TRPG) measured by echocardiography is used to screen for PH and congestive pressure to the liver. Read More

    IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation.
    BMC Gastroenterol 2018 May 9;18(1):61. Epub 2018 May 9.
    Department of Infectious Diseases, Third Affiliated Hospital of Sun-Yat-SenUniversity, GuangZhou, China.
    Background: Hepatitis B virus (HBV) is a hepatotropic DNA virus, and its DNA may be a potent inflammatory molecule. Interferon-inducible protein 16 (IFI16), a newly discovered DNA sensor, plays an important role in the process of inflammation in viral infections. Our study sought to identify a correlation between IFI16 expression and inflammation in patients with chronic hepatitis B (CHB) and HBV-associated acute-on-chronic liver failure (HBV-ACLF). Read More

    Thrombin and factor Xa link the coagulation system with liver fibrosis.
    BMC Gastroenterol 2018 May 8;18(1):60. Epub 2018 May 8.
    Department of Surgery and Cancer, Imperial College London, St Mary's Hospital Campus, London, W2 1NY, UK.
    Background: Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rodent model of hepatic fibrosis. Read More

    Intestinal Candida parapsilosis isolates from Rett syndrome subjects bear potential virulent traits and capacity to persist within the host.
    BMC Gastroenterol 2018 May 2;18(1):57. Epub 2018 May 2.
    Department of Biology, University of Florence, Via Madonna del Piano 6, 50019, Sesto Fiorentino, Florence, Italy.
    Background: Rett syndrome (RTT) is a neurological disorder mainly caused by mutations in MeCP2 gene. It has been shown that MeCP2 impairments can lead to cytokine dysregulation due to MeCP2 regulatory role in T-helper and T-reg mediated responses, thus contributing to the pro-inflammatory status associated with RTT. Furthermore, RTT subjects suffer from an intestinal dysbiosis characterized by an abnormal expansion of the Candida population, a known factor responsible for the hyper-activation of pro-inflammatory immune responses. Read More

    Celiac crisis, a rare and profound presentation of celiac disease: a case report.
    BMC Gastroenterol 2018 May 2;18(1):59. Epub 2018 May 2.
    Diagnostic, Emergency and Medical Services, Gold Coast Hospital and Health Service, Gold Coast University Hospital, 1 Hospital Blvd, Southport, Gold Coast, Queensland, 4215, Australia.
    Background: Celiac crisis is a life-threatening manifestation of celiac disease and is rare in adults, with only a handful of cases documented worldwide and mostly in children.

    Case Presentation: A profoundly emaciated 43-year-old female presented with profuse diarrhoea, shortness of breath, left leg swelling with ulceration and immobility (Body Mass Index (BMI) = 14.7 kg/m). Read More

    Sulphite oxidase (SO) - a mitochondrial autoantigen as target for humoral and cellular immune reactions in primary sclerosing cholangitis.
    BMC Gastroenterol 2018 May 2;18(1):58. Epub 2018 May 2.
    Department of Internal Medicine II, University of Tuebingen, Otfried-Mueller Str. 11, 72076, Tuebingen, Germany.
    Background: In a recent study we had evidence that sulphite oxidase (SO) may be a relevant autoantigen in primary sclerosing cholangitis (PSC). Aim of the present study was, therefore, to analyse humoral and cellular immune-reactivity towards SO in these patients in more detail.

    Methods: Sera from 53 patients with PSC (30 untreated and 23 treated with ursodeoxycholic acid [UDCA] at time of analysis), from 422 patients with different hepatic and non-hepatic disorders, and from 50 healthy individuals were tested by ELISA for antibodies against full-length-SO (SO-fl) and its three major domains expressed in E. Read More

    Functional outcomes in Hirschsprung disease patients after transabdominal Soave and Duhamel procedures.
    BMC Gastroenterol 2018 Apr 27;18(1):56. Epub 2018 Apr 27.
    Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Kesehatan No. 1, Yogyakarta, 55281, Indonesia.
    Background: Several pull-through procedures have been described for Hirschsprung disease (HSCR) with varying functional outcomes. The voluntary bowel movement (VBM) and the absence of soiling or constipation after pull-through remain the most important markers of good outcome. We aimed to compare the functional outcomes in HSCR patients following Soave and Duhamel procedures. Read More

    Relationship between Helicobacter pylori infection and bone mineral density: a retrospective cross-sectional study.
    BMC Gastroenterol 2018 Apr 24;18(1):54. Epub 2018 Apr 24.
    Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Dapi Road, Niaosong District, Kaohsiung, 833, Taiwan.
    Background: Helicobacter pylori (H. pylori) infection can induce individual inflammatory and immune reactions which associated with extra-digestive disorders. Our aim is to investigate the association between H. Read More

    Endoscopic ultrasound-guided transmural drainage for subphrenic abscess: report of two cases and a literature review.
    BMC Gastroenterol 2018 Apr 27;18(1):55. Epub 2018 Apr 27.
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata, 951-8510, Japan.
    Background: An intra-abdominal abscess can sometimes become serious and difficult to treat. The current standard treatment strategy for intra-abdominal abscess is percutaneous imaging-guided drainage. However, in cases of subphrenic abscess, it is important to avoid passing the drainage route through the thoracic cavity, as this can lead to respiratory complications. Read More

    Pancreatic duct obstruction after pancreaticojejunostomy: implications for early prediction and prevention of long-term pancreatic complications.
    BMC Gastroenterol 2018 Apr 23;18(1):53. Epub 2018 Apr 23.
    Department of General Surgery, Peking University Third Hospital, Beijing, 100191, China.
    Background: Pancreatic duct obstructions are common in patients with pancreaticoduodenectomy. However, it is often neglected in follow up. This study was to review the outcomes of pancreatic duct obstruction and explore the prevention of pancreatic duct obstruction. Read More

    Wirsung atraumatic rupture in patient with pancreatic pseudocysts: a case presentation.
    BMC Gastroenterol 2018 Apr 23;18(1):52. Epub 2018 Apr 23.
    Department of Surgery, University of Milan, Via F. Sforza 35, 20122, Milan, Italy.
    Background: Pancreatic duct disruption is a challenging condition leading to pancreatic juice leakage and consequently to pancreatic fluid collections. The manifestations of pancreatic main duct leak include pseudocysts, walled-off necrosis, pancreatic fistulas, ascites, pleural and pericardial effusions. Pseudocyst formation is the most frequent outcome of a pancreatic duct leak. Read More

    Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis.
    BMC Gastroenterol 2018 Apr 19;18(1):51. Epub 2018 Apr 19.
    Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    Background: Several studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histological severity of nonalcoholic fatty liver disease.

    Methods: Pubmed, the Cochrane Library and EMBASE were searched (until August 2017) for studies examining the relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in nonalcoholic fatty liver disease. Pooled odds ratios were estimated by fixed effects models. Read More

    Systematic review of the relationship of Helicobacter pylori infection with geographical latitude, average annual temperature and average daily sunshine.
    BMC Gastroenterol 2018 Apr 17;18(1):50. Epub 2018 Apr 17.
    Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310003, China.
    Background: Helicobacter pylori (H. pylori) infection is a worldwide threat to human health with high prevalence. In this study, we analyzed the relationship between latitude, average annual temperature, average daily sunshine time and H. Read More

    Feasibility of portal or superior mesenteric vein resection and reconstruction by allogeneic vein for pancreatic head cancer-a case-control study.
    BMC Gastroenterol 2018 Apr 16;18(1):49. Epub 2018 Apr 16.
    Department of hepatobiliary surgery, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South Street, Chaoyang District, Beijing, 100021, China.
    Background: There are few reports about resection of portal vein (PV)/superior mesenteric vein (SMV) and reconstruction by using allogeneic vein. This case-control study was designed to explore the feasibility and safety of this operation type in patients with T3 stage pancreatic head cancer.

    Methods: A total of 42 patients (Group A) underwent PV/SMV resection and reconstruction by using allogeneic vein were 1:1 matched to 42 controls (Group B) with other types of resection and reconstruction. Read More

    Dietary habits and Helicobacter pylori infection: a cross sectional study at a Lebanese hospital.
    BMC Gastroenterol 2018 Apr 16;18(1):48. Epub 2018 Apr 16.
    School of Kinesiology and Health Science, York University, Toronto, ON, M3J1P3, Canada.
    Background: To examine the association between dietary habits and Helicobacter pylori (H. pylori) infection among patients at a tertiary healthcare center in Lebanon.

    Methods: This cross-sectional study was conducted on 294 patients in 2016, at a hospital in Northern Lebanon. Read More

    A rare case of skin blistering and esophageal stenosis in the course of epidermolysis bullosa - case report and literature review.
    BMC Gastroenterol 2018 Apr 13;18(1):47. Epub 2018 Apr 13.
    Department of Radiology and Nuclear Medicine, Medical University of Lublin, Jaczewski Str, Lublin, 820-954, Poland.
    Background: Epidermolysis bullosa (EB) constitutes a heterogenous group of rare multisystem genetically transmitted disorders comprising several blistering muco-cutaneous diseases with a monogenic basis and either autosomal dominant or autosomal recessive mode of inheritance. EB manifestation is not only limited to the skin. Systemic signs might involve the nose, ear, eye, genitourinary tract and upper gastrointestinal tract. Read More

    Bleeding in patients who underwent scheduled second-look endoscopy 5 days after endoscopic submucosal dissection for gastric lesions.
    BMC Gastroenterol 2018 Apr 10;18(1):46. Epub 2018 Apr 10.
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, Okayama, 700-8558, Japan.
    Background: Bleeding after endoscopic submucosal dissection (ESD) in antithrombotic drug users is still one of the important issues to be solved. We performed scheduled second-look endoscopy (SLE) 5 days after ESD, when the resumption of antithrombotic agents is assumed to have achieved a steady state, rather than on the day after ESD. We investigated bleeding incidence and the status of ulcers. Read More

    Case report: lactic acidosis and rhabdomyolysis during telbivudine and tenofovir treatment for chronic hepatitis B.
    BMC Gastroenterol 2018 Apr 6;18(1):45. Epub 2018 Apr 6.
    Department of Infectious Diseases, Huashan Hospital Affiliated to Fudan University, 12, Middle Wulumuqi Road, Shanghai, 200040, China.
    Background: Current treatment options for chronic hepatitis B (CHB) are pegylated interferon alpha and nucleoside analogues (NAs). NAs have relatively fewer side effects than interferon alpha, and generally well tolerated. Previously 12. Read More

    3D high-resolution anorectal manometry in patients with perianal fistulas: comparison with 3D-anal ultrasound.
    BMC Gastroenterol 2018 Apr 4;18(1):44. Epub 2018 Apr 4.
    Proctos Clinic, Bilthoven, The Netherlands.
    Background: Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with perianal fistulas. The aim was to measure regional anal pressures with 3D-HRAM and to compare these with 3D-EUS findings in patients with perianal fistulas. Read More

    Irinotecan-containing doublet treatment versus irinotecan monotherapy as second-line choice for advanced gastric cancer.
    BMC Gastroenterol 2018 Apr 2;18(1):43. Epub 2018 Apr 2.
    Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
    Background: For patients with advanced gastric cancer (AGC), second-line chemotherapy regimen remains controversial. The efficacy and safety of irinotecan-containing doublet treatment and irinotecan monotherapy were compared in this systematic analysis.

    Methods: A search was conducted on EMBASE and Medline databases. Read More

    Fitz-Hugh-Curtis syndrome associated with tuberculous salpingitis and peritonitis: a case presentation and review of literature.
    BMC Gastroenterol 2018 Mar 20;18(1):42. Epub 2018 Mar 20.
    Department of Hepatology and Gastroenterology, AZ Sint-Lucas, Groene Briel 1, 9000, Ghent, Belgium.
    Background: Fitz-Hugh-Curtis syndrome or acute perihepatitis is considered a rare complication of pelvic inflammatory disease, mostly associated with chlamydial or gonococcal salpingitis. Peritoneal tuberculosis is a rare site of extra-pulmonary infection caused by Mycobacterium tuberculosis. Infection usually occurs after reactivation of latent tuberculous foci in the peritoneum and more seldom after contiguous spread from tuberculous salpingitis. Read More

    Classification of pediatric functional gastrointestinal disorders related to abdominal pain using Rome III vs. Rome IV criterions.
    BMC Gastroenterol 2018 Mar 17;18(1):41. Epub 2018 Mar 17.
    Division of Developmental and Behavioral Sciences, Children's Mercy Kansas City, 2401 Gillham Road, Kansas City, MO, 64108, USA.
    Background: The primary purpose of this study was to compare Rome III and IV evaluation criteria for irritable bowel syndrome (IBS), functional dyspepsia (FD), and an overlap syndrome consisting of both IBS and FD by assessing the frequency of each diagnosis in a population of children with chronic abdominal pain. Frequencies of Rome IV FD subtypes of postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) were determined and FD/IBS overlap symptom associations were also assessed.

    Methods: We conducted a cross-sectional retrospective chart review of 106 pediatric patients who had completed standardized medical histories as part of their evaluation for chronic abdominal pain. Read More

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