659 results match your criteria BMC Endocrine Disorders[Journal]


Mobile health in the management of type 1 diabetes: a systematic review and meta-analysis.

BMC Endocr Disord 2019 Feb 13;19(1):21. Epub 2019 Feb 13.

Department of Health Statistics, School of Public Health, Inner Mongolia Medical University, Hohhot, 010110, China.

Background: As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However, the effectiveness of mHealth in controlling the glycemic control remains uncertain. Read More

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http://dx.doi.org/10.1186/s12902-019-0347-6DOI Listing
February 2019

Preventing misdiagnosis of diabetes in the elderly: age-dependent HbA1c reference intervals derived from two population-based study cohorts.

BMC Endocr Disord 2019 Feb 12;19(1):20. Epub 2019 Feb 12.

Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany.

Background: Measurement of gylcated hemoglobin A1c (HbA1c) plays a central role in monitoring quality of antidiabetic therapy and in the diagnosis of diabetes. Several studies report increased levels of HbA1c in nondiabetic elderly. However, this observation did not reach incorporation into daily clinical practice or the respective guidelines. Read More

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http://dx.doi.org/10.1186/s12902-019-0338-7DOI Listing
February 2019

The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.

BMC Endocr Disord 2019 Feb 8;19(1):19. Epub 2019 Feb 8.

Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) proteins have an important role in counteracting oxidative stress. Although diabetes and hypothyroidism (HT) are both characterized by oxidative stress, the mechanisms are not fully understood. This study investigated the effects of type 1 diabetes (T1D), type 2 diabetes (T2D), and HT on the expression levels of SIRT1, SIRT3, and manganese superoxide dismutase (SOD2). Read More

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http://dx.doi.org/10.1186/s12902-019-0350-yDOI Listing
February 2019
1 Read

Patterns and trends of utilization of incretin-based medicines between 2008 and 2014 in three Italian geographic areas.

BMC Endocr Disord 2019 Feb 7;19(1):18. Epub 2019 Feb 7.

Epidemiology Unit, Agenzia regionale di sanità della Toscana, Florence, Italy.

Background: The incretin-based medicines GLP1 analogues (GLP1a) and dipeptidyl peptidase-4 inhibitors (DPP4i) are hypoglycaemic agents licensed for the treatment of type 2 diabetes mellitus (T2DM). Although these drugs possess comparable efficacy and low risk of hypoglycaemia, differences in terms of route of administration (subcutaneous versus oral), effect on body weight and gastrointestinal tolerabily can impact their actual use in clinical practice. This study aimed to describe the real-world utilization of incretin-based medicines in the Italian clinical practice. Read More

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http://dx.doi.org/10.1186/s12902-019-0334-yDOI Listing
February 2019
2 Reads

Self-reported hypoglycemia in adult diabetic patients in East Gojjam, Northwest Ethiopia: institution based cross-sectional study.

BMC Endocr Disord 2019 Jan 30;19(1):17. Epub 2019 Jan 30.

Department of Nursing, College of Medicine and Health Sciences, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia.

Background: Hypoglycemia presents a barrier to optimum diabetes management and it is related to a negative impact on health-related quality of life, healthcare resource use, and work productivity. Despite the fact that the magnitude of hypoglycemia and factors associated with hypoglycemia in diabetic population were demonstrated in clinical trial settings; there is no adequate evidence concerning to the problem in real-world settings, in particular in the study area. The aim of the study was to assess the magnitude of hypoglycemia and factors associated with hypoglycemia among adult diabetic patients attending chronic follow up clinic at Debre Markos referral hospital, East Gojjam Zone, Northwest Ethiopia, 2017. Read More

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http://dx.doi.org/10.1186/s12902-019-0341-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354379PMC
January 2019
1 Read

Recurrent tertiary hyperparathyroidism due to supernumerary parathyroid glands in a patient receiving long-term hemodialysis: a case report.

BMC Endocr Disord 2019 Jan 28;19(1):16. Epub 2019 Jan 28.

Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, 539 Chung Hsiao Rd, Chiayi, 600, Taiwan.

Background: Renal hyperparathyroidism is a common complication of chronic kidney disease (CKD) or end-stage renal disease (ESRD) characterized by elevated parathyroid hormone levels secondary to derangements in the homeostasis of calcium, phosphate, and vitamin D. Rapid correction of severe and prolonged hyperparathyroidism by surgical parathyroidectomy in long-term hemodialysis patients occasionally causes hungry bone syndrome. These patients then exhibit severe and long-lasting secondary or tertiary hyperparathyroidism with high bone turnover. Read More

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http://dx.doi.org/10.1186/s12902-019-0346-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350335PMC
January 2019
1 Read

11β Hydroxysteroid dehydrogenase - 1 activity in type 2 diabetes mellitus: a comparative study.

BMC Endocr Disord 2019 Jan 24;19(1):15. Epub 2019 Jan 24.

Medical College Kolkata, Kolkata, India.

Background: A comparative study of 11 β HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted.

Methods: A case control experimental study was performed enrolling thirty type 2 diabetes mellitus patients and thirty age, gender and BMI matched controls using cortisone acetate test.

Results: The rise of serum cortisol after oral 25 mg cortisone acetate from baseline (dexamethasone suppressed level) is higher in subjects with type 2 diabetes and is associated with exercise, BMI, SGOT but not daily calorie intake, lipid parameters and thyroid status. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-019-0344-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345010PMC
January 2019
3 Reads

A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman.

BMC Endocr Disord 2019 Jan 23;19(1):14. Epub 2019 Jan 23.

Department of Endocrinology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, Hangzhou, China.

Background: Hyperandrogenemia is more common in puberty and reproductive age, but relatively rare in postmenopausal women. Postmenopausal virilization may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and are diagnosed as adrenocortical carcinoma, most of which can co-secrete androgen and cortisol. Read More

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http://dx.doi.org/10.1186/s12902-019-0342-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343319PMC
January 2019
1 Read

Serum zinc-α2-glycoprotein levels are elevated and correlated with thyroid hormone in newly diagnosed hyperthyroidism.

BMC Endocr Disord 2019 Jan 22;19(1):12. Epub 2019 Jan 22.

Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, 421001, China.

Background: Zinc-α2-glycoprotein (ZAG) is a recently novel lipolytic adipokine implicated in regulation of glucose and lipid metabolism in many metabolic disorders. In vitro and animal studies suggest that thyroid hormones (TH) up-regulates ZAG production in hepatocytes. However, there is no data evaluating the possible relationship between ZAG and TH in a human model of hyperthyroidism. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-019-0336-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343254PMC
January 2019
3 Reads

A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.

BMC Endocr Disord 2019 Jan 22;19(1):13. Epub 2019 Jan 22.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. Here, we describe the first case of subclinical Cushing's syndrome represented by autonomous cortisol secretion and paradoxical response to oral dexamethasone administration, harboring an activating mutation in the α subunit of the stimulatory G protein (GNAS).

Case Presentation: A 65-year-old woman was diagnosed with subclinical Cushing's syndrome during an evaluation for bilateral adrenal masses. Read More

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http://dx.doi.org/10.1186/s12902-019-0345-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343241PMC
January 2019
1 Read

Plasma glucose in screening for diabetes and pre-diabetes: how much is too much? Analysis of fasting plasma glucose and oral glucose tolerance test in Sri Lankans.

BMC Endocr Disord 2019 Jan 22;19(1):11. Epub 2019 Jan 22.

Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, London, UK.

Background: Fasting plasma glucose (FPG) is the most commonly used screening tool for diabetes in Sri Lanka. Cut-off values from American Diabetes Association recommendations are adopted in the absence of local data. We aimed to establish FPG cut offs for Sri Lankans to screen for diabetes and pre-diabetes. Read More

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http://dx.doi.org/10.1186/s12902-019-0343-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341544PMC
January 2019

Efficacy of Tc-DTPA SPECT/CT in diagnosing Orbitopathy in graves' disease.

BMC Endocr Disord 2019 Jan 18;19(1):10. Epub 2019 Jan 18.

Department of Nuclear Medicine, Medical University of Bialystok, M. Skłodowskiej-Curie St. 24A, 15-276, Bialystok, Poland.

Background: The most frequently used methods of assessing Graves' orbithopathy (GO) include: Clinical Activity Score (CAS), ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI). There exists another, slightly forgotten, imaging method: single-photon emission computed tomography (SPECT) with the use of diethylenetriaminepentaacetic acid tagged with Tc (Tc-DTPA). These days it is possible to conduct a SPECT examination fused with a CT scan (SPECT/CT), which increases the diagnostic value of the investigation. Read More

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http://dx.doi.org/10.1186/s12902-019-0340-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339418PMC
January 2019
4 Reads

Adrenarche and pubarche in girls with turner syndrome during growth-promoting therapy with human growth hormone.

BMC Endocr Disord 2019 Jan 18;19(1). Epub 2019 Jan 18.

Paediatric Endocrinology, University Hospital of Erlangen, Loschgestr. 15, 91054, Erlangen, Germany.

Background: Data on adrenarche and pubarche in girls with Turner syndrome (TS) are inconsistent in the literature.

Methods: The cohort consisted of 94 girls and young women with TS born between 1971 and 2001 (age range: 3.1-23. Read More

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http://dx.doi.org/10.1186/s12902-019-0333-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339350PMC
January 2019
2 Reads

Vitamin-D2 treatment-associated decrease in 25(OH)D3 level is a reciprocal phenomenon: a randomized controlled trial.

BMC Endocr Disord 2019 Jan 18;19(1). Epub 2019 Jan 18.

Department King Faisal Specialist Hospital and Research Center, Clinical Studies and Empirical Ethics, P O Box # 3354, Riyadh, 11211, Saudi Arabia.

Background: Vitamin-D2 (D2) treatment has been associated with a decrease in 25-hydroxy (25(OH)) vitamin-D3 (D3) level, suggesting that D3 treatment would be preferred to raise total 25(OH) vitamin-D (D) level. We postulated that D2 treatment-associated decrease in 25(OH)D3 level is related to the increase in 25(OH)D level rather than being D2-specific, and thus there would be a similar D3 treatment-associated decrease in 25(OH)D2 level.

Methods: Fifty volunteers were block-randomized to 50,000 IU D2 or placebo orally once (study-1) and fifty volunteers received 50,000 IU D2 orally once and 4 days later block-randomized to 50,000 IU D3 or placebo orally once (study-2). Read More

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http://dx.doi.org/10.1186/s12902-019-0337-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339397PMC
January 2019
1 Read

Impact of technology-based interventions for children and young people with type 1 diabetes on key diabetes self-management behaviours and prerequisites: a systematic review.

BMC Endocr Disord 2019 Jan 10;19(1). Epub 2019 Jan 10.

University of Nottingham, School of Health Sciences, Nottingham, UK.

Background: The role of technology in the self-management of type 1 diabetes mellitus (T1DM) among children and young people is not well understood. Interventions should aim to improve key diabetes self-management behaviours (self-management of blood glucose, insulin administration, physical activity and dietary behaviours) and prerequisites (psychological outcomes and HbA1c) highlighted in the UK guidelines of the National Institute for Health and Care Excellence (NICE) for management of T1DM. The purpose was to identify evidence to assess the effectiveness of technological tools in promoting aspects of these guidelines amongst children and young people. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0331-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329145PMC
January 2019
5 Reads

Whole-body vibration improves the functional parameters of individuals with metabolic syndrome: an exploratory study.

BMC Endocr Disord 2019 Jan 9;19(1). Epub 2019 Jan 9.

Laboratório de Vibrações Mecânicas e Práticas Integrativas, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcântara Gomes e Policlínica Américo Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, fundos, 4° andar, Rio de Janeiro, RJ, 20551031, Brazil.

Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increases the cardiovascular risk. Regular physical exercise can promote benefits, but the MetS individuals are demotivated to perform it. Thus, new possibilities are important as an alternative intervention. Read More

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http://dx.doi.org/10.1186/s12902-018-0329-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325843PMC
January 2019
4 Reads
1.673 Impact Factor

Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report.

BMC Endocr Disord 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Diabetes and Metabolism, Tohoku University Hospital, 2-1 Seiryo, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Background: Insulin injection, especially with insulin analogs, occasionally induces the production of insulin antibodies with high binding capacity and low affinity, similar to the insulin autoantibodies characteristic of insulin autoimmune syndrome (IAS). Production of these "IAS-like" insulin antibodies causes marked glycemic fluctuations with postprandial hyperglycemia and fasting hypoglycemia.

Case Presentation: A 66-year-old man with a 27-year history of diabetes was admitted because of marked glycemic fluctuations. Read More

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http://dx.doi.org/10.1186/s12902-018-0326-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325663PMC
January 2019
1 Read

Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials.

BMC Endocr Disord 2019 Jan 7;19(1). Epub 2019 Jan 7.

Civil Aviation General Hospital, Peking University, Beijing, China.

Background: Several clinical trials have studied the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycometabolism and cardiovascular risk factors since they were identified. Because of their cardiovascular benefits and efficacy in lowering glucose, GLP-1RAs are becoming increasingly important in clinical therapy for patients with or without pathoglycaemia. The aim of this study was to assess the effect of the GLP-1RA liraglutide on blood pressure based on randomised controlled trials (RCTs). Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0332-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323665PMC
January 2019
6 Reads

All-cause mortality of insulin plus dipeptidyl peptidase-4 inhibitors in persons with type 2 diabetes.

BMC Endocr Disord 2019 Jan 5;19(1). Epub 2019 Jan 5.

Institute of Population Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan Township, Miaoli County, 35053, Taiwan.

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors could effectively reduce HbA and postprandial hyperglycemia and could incur only minimal danger of hypoglycemia. Patients with uncontrolled diabetes might be treated by the complementary action of insulin plus DPP-4 inhibitors. Here, we compared the all-cause mortality risk between DPP-4 inhibitor users and nonusers with underlying insulin therapy. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0330-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321656PMC
January 2019
6 Reads

Impact of diabetes mellitus on functional exercise capacity and pulmonary functions in patients with diabetes and healthy persons.

BMC Endocr Disord 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Pulmonology and Allergology, Faculty of Medicine, Medical University of Gdansk, Dębinki 7, 80-211, Gdańsk, Poland.

Background: Chronic diabetic complications may afflict all organ tissues, including those of the respiratory system. The six-minute walk test (6MWT) is an alternative and widely used method of assessing functional capacity and is simple to perform. However, to our knowledge, the impact of diabetes mellitus on 6MWT performance has not been investigated previously. Read More

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http://dx.doi.org/10.1186/s12902-018-0328-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318966PMC
January 2019
2 Reads

Mortality in patients with diabetic foot ulcer: a retrospective study of 513 cases from a single Centre in the Northern Territory of Australia.

BMC Endocr Disord 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Endocrinology, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Background: Diabetic foot ulcers (DFU) are a common problem in longstanding diabetes. However, mortality outcomes in Australian patients with DFU are still unclear.

Methods: All patients with DFU presenting for the first time to the Multi-Disciplinary Foot Clinic (MDFC) at Royal Darwin Hospital, Northern Territory Australia, between January 2003 and June 2015 were included in this study. Read More

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http://dx.doi.org/10.1186/s12902-018-0327-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318899PMC
January 2019
2 Reads

A case of malignant insulinoma responsive to somatostatin analogs treatment.

BMC Endocr Disord 2018 Dec 27;18(1):98. Epub 2018 Dec 27.

Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Careggi University Hospital, Florence, Italy.

Background: Insulinoma is a rare tumour representing 1-2% of all pancreatic neoplasms and it is malignant in only 10% of cases. Locoregional invasion or metastases define malignancy, whereas the dimension (> 2 cm), CK19 status, the tumor staging and grading (Ki67 > 2%), and the age of onset (> 50 years) can be considered elements of suspect.

Case Presentation: We describe the case of a 68-year-old man presenting symptoms compatible with hypoglycemia. Read More

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http://dx.doi.org/10.1186/s12902-018-0325-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307122PMC
December 2018
2 Reads

Retrospective assessment of the quality of diabetes care in a rural diabetes clinic in Western Kenya.

BMC Endocr Disord 2018 Dec 27;18(1):97. Epub 2018 Dec 27.

Moi University School of Medicine, Nandi Hills Road, Eldoret, 30100, Kenya.

Background: Sub-Saharan Africa continues to face the highest rate of mortality from diabetes in the world due to limited access to quality diabetes care. We assessed the quality of diabetes care in a rural diabetes clinic in western Kenya.

Methods: To provide a comprehensive assessment, a set of clinical outcomes, process, and structure metrics were evaluated to assess the quality of diabetes care provided in the outpatient clinic at Webuye District Hospital. Read More

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http://dx.doi.org/10.1186/s12902-018-0324-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307239PMC
December 2018
3 Reads

Obese adolescents exhibit a constant ratio of GH isoforms after whole body vibration and maximal voluntary contractions.

BMC Endocr Disord 2018 Dec 27;18(1):96. Epub 2018 Dec 27.

Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Verbania, Italy.

Background: Growth hormone (GH) is a heterogeneous protein composed of several molecular isoforms, the most abundant ones being the 22 kDa- and 20 kDa-GH. Exercise-induced secretion of GH isoforms has been extensively investigated in normal-weight individuals due to antidoping purposes, particularly recombinant human GH (rhGH) abuse. On the other hand, the evaluation of exercise-induced responses in GH isoforms has never been performed in obese subjects. Read More

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http://dx.doi.org/10.1186/s12902-018-0323-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307112PMC
December 2018
1 Read

Association between random glucose and all-cause mortality: findings from the mortality follow-up of the German National Health Interview and Examination Survey 1998.

BMC Endocr Disord 2018 Dec 13;18(1):95. Epub 2018 Dec 13.

Department of Epidemiology and Health Monitoring, Robert Koch Institute, General-Pape-Strasse 62-66, D-12101, Berlin, Germany.

Background: Random glucose is widely measured in epidemiological studies and in the clinical setting when standardized fasting protocols and oral glucose tolerance testing or HbA measuring are not feasible. The relationship between random glucose and all-cause mortality has hardly been studied so far and was examined in the present study.

Methods: We ascertained mortality status among 5955 persons aged 18-79 years and free of known diabetes when participating in the German National Health Interview and Examination Survey 1998 (mean observation time 11. Read More

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http://dx.doi.org/10.1186/s12902-018-0319-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293613PMC
December 2018
1 Read

Radioiodine treatment for graves' disease: a 10-year Australian cohort study.

BMC Endocr Disord 2018 Dec 12;18(1):94. Epub 2018 Dec 12.

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Background: Radioactive iodine (I) is a common definitive treatment for Graves' Disease. Potential complications include worsening, or new development of Graves' eye disease and development of a radiation thyroiditis. The purpose of the present study was to assess outcomes of patients treated with I in an Australian tertiary centre over 10 years. Read More

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http://dx.doi.org/10.1186/s12902-018-0322-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292026PMC
December 2018
1 Read

Investigation and management of moderate to severe inpatient hyponatraemia in an Australian tertiary hospital.

BMC Endocr Disord 2018 Dec 6;18(1):93. Epub 2018 Dec 6.

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba, Brisbane, QLD, 4102, Australia.

Background: Hyponatraemia is the most common electrolyte disturbance amongst hospitalised patients. Both American and European guidelines recommend fluid restriction as first line treatment for SIADH, however differ on second line recommendations. The objective of this study was to examine investigation and management of hyponatraemia in hospitalised patients in an Australian tertiary hospital. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0320-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282347PMC
December 2018
8 Reads

Clinical Management of Malignant Insulinoma: a single Institution's experience over three decades.

BMC Endocr Disord 2018 Dec 6;18(1):92. Epub 2018 Dec 6.

Department of Endocrinology, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, China.

Background: Malignant insulinoma is extremely rare and accounts for only 10% of total insulinoma cases. The goal of this study is to retrospectively analyze clinical data from 15 patients with malignant insulinoma treated at Peking Union Medical College Hospital (PUMCH) from 1984 to April 2017.

Methods: "Malignant insulinoma" was used as the keywords in the PUMCH medical record retrieval system to search and obtain patients' clinical information. Read More

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http://dx.doi.org/10.1186/s12902-018-0321-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282250PMC
December 2018
2 Reads

Pre-diabetes and diabetes are independently associated with adverse cognitive test results: a cross-sectional, population-based study.

BMC Endocr Disord 2018 Dec 4;18(1):91. Epub 2018 Dec 4.

Department of Acute Internal Medicine and Geriatrics, Linköping University, S-581 85, Linköping, Sweden.

Background: Diabetes is a risk factor for cognitive impairment, but whether there is also a link between pre-diabetes and cognitive dysfunction is not yet fully established. The aim of this observational study was to investigate associations between pre-diabetes/diabetes and cognitive test results, and also between glucose levels measured during the Oral Glucose Tolerance Test (OGTT) and cognitive outcomes.

Methods: During 2007-2012, in all 2994 people (mean age 72 years), residing in Malmö, Sweden, underwent a clinical examination including the OGTT, cardiovascular measurements including carotid-femoral pulse wave velocity (c-f PWV) and two cognitive tests, the Mini Mental State Examination (MMSE), measuring global cognitive function, and A Quick Test of Cognitive Speed (AQT), measuring processing speed and executive functioning. Read More

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http://dx.doi.org/10.1186/s12902-018-0318-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278035PMC
December 2018
2 Reads

Cardiovascular risk reduction over time in patients with diabetes or pre-diabetes undergoing bariatric surgery: data from a single-center retrospective observational study.

BMC Endocr Disord 2018 Nov 28;18(1):90. Epub 2018 Nov 28.

Departamento de Endocrinología y Nutrición, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Background: Bariatric surgery is effective in remission of obesity comorbidities. This study was aimed at comparing CVD risk between morbidly obese patients with type 2 diabetes and pre-diabetes before and after bariatric surgery as well as assessing comorbidities.

Methods: This is a retrospective observational study with 105 patients with type 2 diabetes (DMbaseline) and prediabetes (preDMbaseline) who underwent Roux-en-Y gastric bypass. Read More

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http://dx.doi.org/10.1186/s12902-018-0317-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263178PMC
November 2018
1 Read

Analysis of influencing factor of coexisting prediabetes and prehypertension in adult residents of Jilin Province.

BMC Endocr Disord 2018 Nov 26;18(1):89. Epub 2018 Nov 26.

Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, 130021, China.

Background: To explore the risk factors of coexisting prediabetes and prehypertension, to provide theoretical basis for early intervention.

Methods: A multi-stage stratified random cluster sampling method was used to randomly select adult residents from Jilin Province in 2013 for questionnaire surveys, physical examinations, and laboratory tests.

Results: The prevalence of coexisting prediabetes and prehypertension in Jilin Province was 11. Read More

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http://dx.doi.org/10.1186/s12902-018-0316-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258491PMC
November 2018
1 Read

Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis.

BMC Endocr Disord 2018 Nov 26;18(1):87. Epub 2018 Nov 26.

Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.

Background: Cognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association of vitamin D levels with cognitive impairment in patients with HT. Read More

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http://dx.doi.org/10.1186/s12902-018-0314-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260768PMC
November 2018
11 Reads

Treatment with PBI-4050 in patients with Alström syndrome: study protocol for a phase 2, single-Centre, single-arm, open-label trial.

BMC Endocr Disord 2018 Nov 26;18(1):88. Epub 2018 Nov 26.

Centre for Rare Disease, Department of Inherited Metabolic Disorders, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, B15 2TH, UK.

Background: Alström syndrome (ALMS) is a very rare autosomal recessive monogenic disorder caused by a mutation in the ALMS1 gene and characterised by childhood onset obesity, dyslipidaemia, advanced non-alcoholic fatty liver disease, diabetes and extreme insulin resistance. There is evidence of multi-organ fibrosis in ALMS and severity of the disease often leads to organ failure with associated morbidities, resulting in reduced life expectancy. There are no specific treatments for this disease, and current management consists of only symptomatic therapies. Read More

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http://dx.doi.org/10.1186/s12902-018-0315-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258144PMC
November 2018
9 Reads

Assisted reproductive techniques with congenital hypogonadotropic hypogonadism patients: a systematic review and meta-analysis.

BMC Endocr Disord 2018 Nov 19;18(1):85. Epub 2018 Nov 19.

Key laboratory of Endocrinology, Ministry of Health; Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Wang Fu Jing St, Dongcheng district, Beijing, 100730, China.

Background: After hormonal replacement therapy (HRT) including androgen replacement or sequential therapy of estrogen and progesterone, The combination of human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) and pulsatile GnRH, is not sufficient to produce sufficient gametes in some patients with Congenital hypogonadotropic hypogonadism (CHH). A Systematic review and meta-analysis was performed to determine that assisted reproductive techniques (ART) can effectively treat different causes of infertility.

Methods: To determine the effect of ART on fertility of CHH patients and investigate whether outcomes are similar to infertility due to other causes, we conducted a systematic review and meta-analysis of retrospective trials. Read More

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http://dx.doi.org/10.1186/s12902-018-0313-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245556PMC
November 2018
3 Reads
1.673 Impact Factor

Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt's lymphoma: a case report and review of the literature.

BMC Endocr Disord 2018 Nov 19;18(1):86. Epub 2018 Nov 19.

Department of Medical Surgical and Health Sciences, Università degli Studi di Trieste, Cattinara Teaching Hospital, Strada di Fiume 447, 34149, Trieste, Italy.

Background: Thyroid lymphomas are an exceptional finding in patients with thyroid nodules. Burkitt's lymphoma is one of the rarest and most aggressive forms of thyroid lymphomas, and its prognosis depends on the earliness of medical treatment. Given the rarity of this disease, making a prompt diagnosis can be challenging. Read More

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http://dx.doi.org/10.1186/s12902-018-0312-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245622PMC
November 2018
3 Reads

The ratio of AGE to sRAGE independently associated with albuminuria in hypertensive patients.

BMC Endocr Disord 2018 Nov 13;18(1):84. Epub 2018 Nov 13.

Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Soluble receptor for advanced glycation end-products (sRAGE) and advanced glycation end-products (AGE) have been associated with risks of cardiovascular disease. Because sRAGE is regarded as a scavenger to AGE, we hypothesized that the ratio of AGE to sRAGE (AGE/sRAGE) is associated with albuminuria in hypertensive patients.

Methods: In this cross-sectional study, a total of 104 patients with essential hypertension were recruited. Read More

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http://dx.doi.org/10.1186/s12902-018-0306-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234555PMC
November 2018
8 Reads

Short stature as a presenting symptom of attenuated Mucopolysaccharidosis type I: case report and clinical insights.

BMC Endocr Disord 2018 Nov 12;18(1):83. Epub 2018 Nov 12.

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, Liu Research Building, Torrance, CA, 90502, USA.

Background: Mucopolysaccharidosis type I (MPS I) results in significant disease burden and early treatment is important for optimal outcomes. Recognition of short stature and growth failure as symptoms of MPS I among pediatric endocrinologists may lead to earlier diagnosis and treatment.

Case Presentation: A male patient first began experiencing hip pain at 5 years of age and was referred to an endocrinologist for short stature at age 7. Read More

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http://dx.doi.org/10.1186/s12902-018-0311-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233567PMC
November 2018
3 Reads

Complicated Gitelman syndrome and autoimmune thyroid disease: a case report with a new homozygous mutation in the SLC12A3 gene and literature review.

BMC Endocr Disord 2018 Nov 8;18(1):82. Epub 2018 Nov 8.

The Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

Background: Gitelman syndrome (GS) is an inherited autosomal recessive renal tubular disorder characterized by low levels of potassium and magnesium in the blood, decreased excretion of calcium in the urine, and elevated blood pH. GS is caused by an inactivating mutation in the SLC12A3 gene, which is located on the long arm of chromosome 16 (16q13) and encodes a thiazide-sensitive sodium chloride cotransporter (NCCT).

Case Presentation: A 45-year-old man with Graves' disease complicated by paroxysmal limb paralysis had a diagnosis of thyrotoxic periodic paralysis for 12 years. Read More

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http://dx.doi.org/10.1186/s12902-018-0298-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225570PMC
November 2018
2 Reads

Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis.

BMC Endocr Disord 2018 Nov 6;18(1):81. Epub 2018 Nov 6.

Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: This meta-analytic study explored the relationship between the risk of type 2 diabetes mellitus (T2DM) and bisphenol A concentrations.

Methods: The Embase and Medline (PubMed) databases were searched, using relevant keywords, for studies published between 1980 and 2018. A total of 16 studies, twelve cross-sectional, two case-control and one prospective, were included in the meta-analysis. Read More

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http://dx.doi.org/10.1186/s12902-018-0310-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219165PMC
November 2018
18 Reads

Long-term follow-up in a Chinese child with congenital lipoid adrenal hyperplasia due to a StAR gene mutation.

BMC Endocr Disord 2018 Nov 6;18(1):78. Epub 2018 Nov 6.

Department of Endocrinology, Shenzhen Children's Hospital, 7019# Yitian Road, Futian District, Shenzhen, 518038, Guangdong Province, China.

Background: Congenital lipoid adrenal hyperplasia (CLAH) is an extremely rare and the most severe form of congenital adrenal hyperplasia. Typical features include disorder of sex development, early-onset adrenal crisis and enlarged adrenal glands with fatty accumulation.

Case Presentation: We report a case of CLAH caused by mutations in the steroidogenic acute regulatory protein (StAR) gene. Read More

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http://dx.doi.org/10.1186/s12902-018-0307-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219181PMC
November 2018
10 Reads
1.673 Impact Factor

C-Peptide and cardiovascular risk factors among young adults in a southern Brazilian cohort.

BMC Endocr Disord 2018 Nov 6;18(1):80. Epub 2018 Nov 6.

Post-Graduate Program in Epidemiology, Federal University of Pelotas (UFPel), Pelotas-RS, Brazil.

Background: Proinsulin connecting peptide (C-Peptide) is a marker of the beta-cell function and has been considered a marker of insulin resistance whose evidence suggests were associated with cardiovascular mortality. Our study aims to evaluate the association of C-Peptide with metabolic cardiovascular risk factors among young adults followed since birth in southern Brazil.

Methods: In 1982, maternity hospital in Pelotas, a southern Brazilian city, were visited daily and all births were identified. Read More

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http://dx.doi.org/10.1186/s12902-018-0308-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218973PMC
November 2018
6 Reads

Exploring how patients understand and assess their diabetes control.

BMC Endocr Disord 2018 Nov 6;18(1):79. Epub 2018 Nov 6.

Michael J. Crescenz VA Medical Center, 3900 Woodland Ave, Philadelphia, PA, 19104, USA.

Background: Poor understanding of diabetes management targets is associated with worse disease outcomes. Patients may use different information than providers to assess their diabetes control. In this study, we identify the information patients use to gauge their current level of diabetes control and explore patient-perceived barriers to understanding the hemoglobin A1c value (HbA1c). Read More

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http://dx.doi.org/10.1186/s12902-018-0309-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219190PMC
November 2018
9 Reads

Effect of imatinib on plasma glucose concentration in subjects with chronic myeloid leukemia and gastrointestinal stromal tumor.

BMC Endocr Disord 2018 Nov 3;18(1):77. Epub 2018 Nov 3.

Department of Internal Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga #15, Sección XVI Tlalpan, 14000, Mexico City, Mexico.

Background: Type 2 diabetes mellitus has become one of the most important public health concerns worldwide. Due to its high prevalence and morbidity, there is an avid necessity to find new therapies that slow the progression and promote the regression of the disease. Imatinib mesylate is a tyrosine kinase inhibitor that binds to the Abelson tyrosine kinase and related proteins. Read More

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http://dx.doi.org/10.1186/s12902-018-0303-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215634PMC
November 2018
9 Reads

Novel missense mutation in PTPN22 in a Chinese pedigree with Hashimoto's thyroiditis.

BMC Endocr Disord 2018 Nov 1;18(1):76. Epub 2018 Nov 1.

Center for Genetics, National Research Institute of Family Planning, Beijing, China.

Background: Hashimoto's thyroiditis is a complex autoimmune thyroid disease, the onset of which is associated with environmental exposures and specific susceptibility genes. Its incidence in females is higher than its incidence in males. Thus far, although some susceptibility loci have been elaborated, including PTPN22, FOXP3, and CD25, the aetiology and pathogenesis of Hashimoto's thyroiditis remains unclear. Read More

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http://dx.doi.org/10.1186/s12902-018-0305-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211547PMC
November 2018
4 Reads

Glycemic control with a basal-bolus insulin protocol in hospitalized diabetic patients treated with glucocorticoids: a retrospective cohort study.

BMC Endocr Disord 2018 Oct 29;18(1):75. Epub 2018 Oct 29.

Endocrinology Unit, Haemek Medical Center, Rabin Ave 21, Afula, Israel, 18134, Afula, Israel.

Background: Improved glycemic control is the desired outcome after the discharge of patients with diabetes. We aimed to determine the efficacy of a basal-bolus insulin protocol in hospitalized patients with diabetes treated with glucocorticoids.

Methods: A retrospective cohort study compared the glycemic control of 150 hospitalized patients with diabetes and elevated inflammatory markers who were either treated with (n = 61) or without glucocorticoids (n = 89). Read More

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http://dx.doi.org/10.1186/s12902-018-0300-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206674PMC
October 2018
10 Reads

Effectiveness of diabetes self-management education via a smartphone application in insulin treated type 2 diabetes patients - design of a randomised controlled trial ('TRIGGER study').

BMC Endocr Disord 2018 Oct 22;18(1):74. Epub 2018 Oct 22.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Background: Health care providers aim to stimulate self-management in type 2 diabetes (T2DM) patients. However, they have a limited number of patient contacts to do this. With the growing number of T2DM patients, innovative and cost-effective interventions to promote self-management are needed. Read More

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http://dx.doi.org/10.1186/s12902-018-0304-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196442PMC
October 2018
5 Reads

A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study.

BMC Endocr Disord 2018 Oct 19;18(1):73. Epub 2018 Oct 19.

Department of Epidemiology, Dalian Medical University, Lvshun West 9, Dalian, 116044, China.

Background: The present study aims to improve the M-stage classification of pancreatic neuroendocrine neoplasms (pNENs).

Methods: Two thousand six hundred sixty six pNENs were extracted from the Surveillance, Epidemiology, and End Results database to explore the metastatic patterns of pNENs. Metastatic patterns were categorized as single, two, or multiple (three or more) distant organ metastasis. Read More

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http://dx.doi.org/10.1186/s12902-018-0301-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194708PMC
October 2018
4 Reads

Protocol of a cluster randomized trial to investigate the impact of a type 2 diabetes risk prediction model on change in physical activity in primary care.

BMC Endocr Disord 2018 Oct 16;18(1):72. Epub 2018 Oct 16.

Institute for Biometrics and Epidemiology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.

Background: Little evidence exists on the impact of diabetes risk scores, e.g. on physicians and patient's behavior, perceived risk of persons, shared-decision making and particularly on patient's health. Read More

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http://dx.doi.org/10.1186/s12902-018-0299-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192326PMC
October 2018
5 Reads

Barriers and facilitators to taking on diabetes self-management tasks in pre-adolescent children with type 1 diabetes: a qualitative study.

BMC Endocr Disord 2018 Oct 13;18(1):71. Epub 2018 Oct 13.

The Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.

Background: When children with type 1 diabetes approach adolescence, they are encouraged to become more involved in diabetes self-management. This study explored the challenges pre-adolescent children encounter when self-managing diabetes and the factors which motivate and enable them to take on new diabetes-related tasks. A key objective was to inform the support offered to pre-adolescent children. Read More

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http://dx.doi.org/10.1186/s12902-018-0302-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186043PMC
October 2018
1 Read
1.673 Impact Factor

Vitamin D status in healthy black African adults at a tertiary hospital in Nairobi, Kenya: a cross sectional study.

BMC Endocr Disord 2018 Oct 11;18(1):70. Epub 2018 Oct 11.

Department of Pathology, Maseno University, P.O. Box Private Bag, Maseno, Kenya.

Background: Vitamin D has been known since the twentieth Century for its benefits in bone health. Recent observational studies have demonstrated its benefits in infectious diseases such as tuberculosis and non-communicable diseases such as diabetes mellitus, cardiovascular diseases and cancer. This has led to a dramatic increase in testing among adults. Read More

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http://dx.doi.org/10.1186/s12902-018-0296-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180659PMC
October 2018
1 Read