885 results match your criteria BMC Endocrine Disorders[Journal]


Neutrophil: lymphocyte ratio is positively associated with subclinical diabetic cardiomyopathy.

BMC Endocr Disord 2020 Jun 30;20(1):99. Epub 2020 Jun 30.

Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou City, 213003, China.

Background: Subclinical diabetic cardiomyopathy (DCM) occurs frequently in asymptomatic subjects with Type 2 diabetes mellitus (T2DM). The direct association between the immune system and DCM with effective biomarkers has been demonstrated in previous studies.

Methods: Five hundred seven subjects with T2DM were recruited from April 2018 to October 2019 and divided into T2DM with cardiac dysfunction (DCM) group and T2DM without cardiac dysfunction (non-DCM) group. Read More

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http://dx.doi.org/10.1186/s12902-020-00571-yDOI Listing

Impact of obesity and metabolic health status in the development of non-alcoholic fatty liver disease (NAFLD): A United Kingdom population-based cohort study using the health improvement network (THIN).

BMC Endocr Disord 2020 Jun 30;20(1):96. Epub 2020 Jun 30.

Institute of Applied Health Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Background: With the obesity epidemic reaching crisis levels, there has been attention around those who may be resilient to the effects of obesity, termed metabolically healthy obesity (MHO), who initially present without associated metabolic abnormalities. Few longitudinal studies have explored the relationship between MHO and non-alcoholic fatty liver disease (NAFLD), which we address using over 4 million primary care patient records.

Methods: A retrospective population-based longitudinal cohort was conducted using The Health Improvement Network (THIN) database incorporating adults with no history of NAFLD or alcohol excess at baseline. Read More

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http://dx.doi.org/10.1186/s12902-020-00582-9DOI Listing

Association between sleep disorder and quality of life in patients with type 2 diabetes: a cross-sectional study.

BMC Endocr Disord 2020 Jun 30;20(1):98. Epub 2020 Jun 30.

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: We investigated the association between sleep symptoms, which cause sleep disorder, and quality of life (QoL) among people with type 2 diabetes (T2D).

Methods: In this cross-sectional study of 342 people with T2D, the Japan National Health and Wellness Survey (NHWS) database 2016 were used. We treated the respondents who reported experiencing any of the sleep symptoms as having sleep disorders. Read More

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http://dx.doi.org/10.1186/s12902-020-00579-4DOI Listing

The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves' disease: a case report.

BMC Endocr Disord 2020 Jun 30;20(1):97. Epub 2020 Jun 30.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai, 200233, China.

Background: Hyperthyroidism-induced hypercalcemia has been reported previously, but hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement in patients with hyperthyroidism is quite rare. We report the coexistence of hypercalcemia, osteoporosis and thymic enlargement in a patient with Graves' disease.

Case Presentation: A 22-year-old female was diagnosed as Graves' disease with obviously elevated serum calcium and reduced parathyroid hormone levels. Read More

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http://dx.doi.org/10.1186/s12902-020-00583-8DOI Listing

"I had no other choice but to catch it too": the roles of family history and experiences with diabetes in illness representations.

BMC Endocr Disord 2020 Jun 26;20(1):95. Epub 2020 Jun 26.

Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut Street, Suite, Philadelphia, PA, 300, USA.

Background: A family history of diabetes and family members' experiences with diabetes may influence individuals' beliefs and expectations about their own diabetes. No qualitative studies have explored the relationship between family history and experiences and individuals' diabetes illness representations.

Methods: Secondary data analysis of 89 exploratory, semi-structured interviews with adults with type 1 or type 2 diabetes seeking care in an urban health system. Read More

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http://dx.doi.org/10.1186/s12902-020-00580-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318544PMC

Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes.

BMC Endocr Disord 2020 Jun 24;20(1):94. Epub 2020 Jun 24.

Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.

Background: Caloric restriction is an effective way to treat Type 2 diabetes (T2D). However, chronic and severe restriction of food intake is difficult to sustain and is known to promote slower metabolism. Intermittent and frequent fasting can exert similar metabolic effects, but may be even more challenging for most patients. Read More

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http://dx.doi.org/10.1186/s12902-020-00576-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315472PMC

Low uptake of continuous subcutaneous insulin infusion therapy in people with type 1 diabetes in Ireland: a retrospective cross-sectional study.

BMC Endocr Disord 2020 Jun 23;20(1):92. Epub 2020 Jun 23.

3U Diabetes, RCSI: University of Medicine and Health Scineces, Dublin, Ireland.

Background: The uptake of continuous subcutaneous insulin infusion (CSII) therapy in those with type 1 diabetes varies internationally and is mainly determined by the national healthcare reimbursement systems. The aim of this study is to estimate national and regional uptake of CSII therapy in children, adolescents and adults with type 1 diabetes in Ireland.

Methods: A retrospective cross-sectional study was conducted utilizing the national pharmacy claims database in 2016. Read More

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http://dx.doi.org/10.1186/s12902-020-00573-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310521PMC

A rare long-term undetected pheochromocytoma leading to Takotsubo syndrome in an older male patient: a case report.

BMC Endocr Disord 2020 Jun 23;20(1):93. Epub 2020 Jun 23.

Department of Cardiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, #79, Qingchun Road, Zhejiang, 310003, Hangzhou, China.

Background: Takotsubo syndrome is an uncommon, acute, and reversible cardiomyopathy that occurs primarily in postmenopausal females. The clinical presentation of the syndrome resembles acute coronary syndrome, but coronary angiography reveals no obstructive coronary artery disease. Rarely, a catecholamine surge due to pheochromocytoma may induce Takotsubo syndrome. Read More

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http://dx.doi.org/10.1186/s12902-020-00578-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313138PMC

Expression of unfolded protein response markers in the pheochromocytoma with Waardenburg syndrome: a case report.

BMC Endocr Disord 2020 Jun 22;20(1):90. Epub 2020 Jun 22.

The First Department of Medicine, Wakayama Medical University, 811-1 Kimi-idera, Wakayama, Wakayama, 641-8509, Japan.

Background: It is clinically emergent to further understand the pathological mechanism to advance therapeutic strategy for endocrine tumors. A high amount of secretory protein with tumorigenic triggers are thought to induce unfolded protein response in endoplasmic reticulum in endocrine tumors, but its evidence is limited.

Case Presentation: A 40-year-old woman had an approximately 10-year history of intermittent headaches. Read More

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http://dx.doi.org/10.1186/s12902-020-00574-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309974PMC

Changing the patterns of hospitalized diabetic foot ulcer (DFU) over a 5-year period in a multi-disciplinary setting in Thailand.

BMC Endocr Disord 2020 Jun 22;20(1):89. Epub 2020 Jun 22.

Diabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.

Background: After years of decline, the rate of amputations was reported to increase by 50% in the U.S. population between 2009 and 2015. Read More

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http://dx.doi.org/10.1186/s12902-020-00568-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310152PMC

Relationships between menstrual status and obesity phenotypes in women: a cross-sectional study in northern China.

BMC Endocr Disord 2020 Jun 22;20(1):91. Epub 2020 Jun 22.

School of public health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong Province, China.

Background: One of most important concerns of postmenopausal women is obesity. The relationships between menstruation status and obesity phenotypes are unclear. This study aimed to assess the associations between menstrual status and different obesity phenotypes in women. Read More

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http://dx.doi.org/10.1186/s12902-020-00577-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310131PMC

Diabetes conversation map - a novel tool for diabetes management self-efficacy among type 2 diabetes patients in Pakistan: a randomized controlled trial.

BMC Endocr Disord 2020 Jun 16;20(1):88. Epub 2020 Jun 16.

Indus college of Allied Health, The Indus Hospital, Karachi, Pakistan.

Background: This study aimed to measure the effect of diabetes education using the novel method of "diabetes conversation map (DCM)" as compared to routine counselling (RC) on diabetes management self-efficacy (DMSE) among patients living with type 2 diabetes in Karachi, Pakistan.

Methods: A parallel arm randomized controlled trial among patients with type 2 diabetes aged 30-60 years, with HbA1c > 7%, diagnosed for at least 5 yrs., was conducted at the national institute of diabetes and endocrinology in Karachi, Pakistan. Read More

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http://dx.doi.org/10.1186/s12902-020-00572-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298747PMC
June 2020
1.673 Impact Factor

Comparison of indirect markers of insulin resistance in adult patients with Double Diabetes.

BMC Endocr Disord 2020 Jun 15;20(1):87. Epub 2020 Jun 15.

Servicio de Endocrinología, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Cuauhtémoc No. 330, Colonia Doctores, Mexico City, Mexico.

Background: The presence of insulin resistance (IR) and metabolic syndrome (MS) in patients with type 1 diabetes (T1D) has been called "double diabetes". This entity increases the risk for development of micro and macrovascular complications and cardiovascular mortality. The gold standard for IR quantification is the hyperinsulinemic euglycemic clamp (HEC) but it is invasive, time-consuming and not available in the majority of the clinical settings. Read More

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http://dx.doi.org/10.1186/s12902-020-00570-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296956PMC

Study rationale and design of the EANITIATE study (EmpAgliflozin compared to NPH Insulin for sTeroId diAbeTEs) - a randomized, controlled, multicenter trial of safety and efficacy of treatment with empagliflozin compared with NPH-insulin in patients with newly onset diabetes following initiation of glucocorticoid treatment.

BMC Endocr Disord 2020 Jun 15;20(1):86. Epub 2020 Jun 15.

Department of Endocrinology and Nephrology, Nordsjaellands Hospital, Dyrehavevej 29, DK-3400, Hilleroed, Denmark.

Background: A well-known metabolic side effect from treatment with glucocorticoids is glucocorticoid-induced diabetes mellitus (GIDM). Guidelines on the management of GIDM in hospitalized patients (in the non-critical care setting), recommend initiation of insulin therapy. The scientific basis and evidence for superiority of insulin therapy over other glucose lowering therapies is however poor and associated with episodes of both hypo- and hyperglycaemia. Read More

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http://dx.doi.org/10.1186/s12902-020-00561-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296645PMC

Evaluation of risk factors for insulin resistance: a cross sectional study among employees at a private university in Lebanon.

BMC Endocr Disord 2020 Jun 10;20(1):85. Epub 2020 Jun 10.

Department of Nursing and Health Sciences, Notre Dame University- Louaize (NDU), Zouk Mosbeh, Lebanon.

Background: Worldwide, the prevalence of insulin resistance ranges from 15.5 to 46.5%, among adults. Read More

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http://dx.doi.org/10.1186/s12902-020-00558-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288486PMC

Correction to: High normal TSH is associated with lower mannan-binding lectin in women of childbearing age.

BMC Endocr Disord 2020 Jun 9;20(1):82. Epub 2020 Jun 9.

Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s12902-020-00564-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282126PMC

Role of F-fluorodeoxyglucose (FDG) and F-2-fluorodeoxy sorbitol (FDS) in autoimmune hypophysitis: a case report.

BMC Endocr Disord 2020 Jun 9;20(1):84. Epub 2020 Jun 9.

Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, China.

Background: Autoimmune hypophysitis is a rare disease characterized by the infiltration of lymphocytic cells into the pituitary gland. F-fluorodeoxyglucose (FDG) and F-2-fluorodeoxy sorbitol (FDS) positron emission tomography (PET) are well-established and emerging techniques, respectively, which may aid in the diagnosis and classification of autoimmune hypophysitis.

Case Presentation: Here, we report a 40-year-old female diagnosed with central diabetes insipidus and multiple pituitary hormone deficiencies, and MRI revealed homogeneous signals in the pituitary gland as well as thickened in the pituitary stalk. Read More

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http://dx.doi.org/10.1186/s12902-020-00567-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285776PMC

Subclinical hypothyroidism and the risk of cancer incidence and cancer mortality: a systematic review.

BMC Endocr Disord 2020 Jun 9;20(1):83. Epub 2020 Jun 9.

Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, 3755 Côte Sainte-Catherine, H-425, Montreal, Quebec, H3T 1E2, Canada.

Background: Thyroid hormone has been shown to be involved in carcinogenesis via its effects on cell proliferation pathways. The objective of this study is to determine the association between subclinical hypothyroidism (SCH) and the risk of incident cancer and cancer mortality via systematic review.

Methods: A systematic search was performed on Medline and Pubmed to identify relevant studies. Read More

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http://dx.doi.org/10.1186/s12902-020-00566-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285584PMC

The relationship between obesity, diabetes, hypertension and vitamin D deficiency among Saudi Arabians aged 15 and over: results from the Saudi health interview survey.

BMC Endocr Disord 2020 Jun 5;20(1):81. Epub 2020 Jun 5.

Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

Background: Obesity and diabetes are related conditions, the prevalence of which has increased globally in recent years. These conditions have been linked to hypertension and vitamin D deficiency though the nature of the relationship remains unclear and is likely to vary between identifiable groups and specific contexts. The aim of this paper is to examine the relationships between obesity, type 2 diabetes, hypertension and vitamin D, among Saudis citizens aged 15 and over. Read More

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http://dx.doi.org/10.1186/s12902-020-00562-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275458PMC

Compartment syndrome of the leg after thyroid hormone withdrawal; two cases and a systematic review of the literature.

BMC Endocr Disord 2020 Jun 5;20(1):80. Epub 2020 Jun 5.

Department of Orthopedic and Trauma Surgery, Luzerner Kantonsspital Luzern, P.O. Box, Spitalstrasse, 6000, Lucerne, Switzerland.

Background: Acute compartment syndrome is a rare complication of severe hypothyroidism. If the symptoms are not recognized promptly and treatment initiated immediately, there is a high risk of permanent damage. Only few other cases of compartment syndrome due to hypothyroidism have been published and the exact pathophysiological mechanism remains unknown. Read More

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http://dx.doi.org/10.1186/s12902-020-00555-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275613PMC

Large mid-upper arm circumference is associated with metabolic syndrome in middle-aged and elderly individuals: a community-based study.

BMC Endocr Disord 2020 Jun 3;20(1):78. Epub 2020 Jun 3.

Department of Endocrinology, Xinhua Hospital Chongming Branch, Shanghai Jiaotong University School of Medicine, 25 Nanmen Road, Shanghai, 202150, China.

Background: The mid-upper arm circumference (MUAC) is a proxy for subcutaneous fat in the upper body and is a reliable screening measure for identifying individuals with abnormal regional fat distribution. The purpose of this study was to evaluate the association between MUAC and metabolic syndrome (MetS) in middle-aged and elderly individuals.

Methods: We measured the MUAC in a cross-sectional sample with a total of 9787 subjects aged 40 years and older. Read More

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http://dx.doi.org/10.1186/s12902-020-00559-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268597PMC

Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study.

BMC Endocr Disord 2020 Jun 3;20(1):79. Epub 2020 Jun 3.

Institute and department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No.639 Zhizaoju Road, Shanghai, China.

Background: Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH) D is still unclear in the eastern Chinese population.

Methods: We did a population-based observational investigation, which included 12,770 residents living in eastern China. Read More

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http://dx.doi.org/10.1186/s12902-020-00560-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268462PMC

Predictors of euthyreosis in hyperthyroid patients treated with radioiodine I: a retrospective study.

BMC Endocr Disord 2020 Jun 1;20(1):77. Epub 2020 Jun 1.

Department of Internal Medicine, Endocrinology and Diabetology, Central Clinical Hospital of the Ministry of the Interior, Wołoska 137, 02-507, Warsaw, Poland.

Background: Radioiodine (RAI) treatment for hyperthyroidism is a very common modality, chosen by physicians worldwide. The outcome of the therapy, however, is not always predictable. While rendering a patient hypo- or euthyroid is meant as a therapeutic success, the latter does not require lifelong hormonal supplementation. Read More

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http://dx.doi.org/10.1186/s12902-020-00551-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268615PMC

Predictive factors for early hypothyroidism following the radioactive iodine therapy in Graves' disease patients.

BMC Endocr Disord 2020 May 29;20(1):76. Epub 2020 May 29.

Department of Nuclear Medicine, Linyi People's Hospital, Cheeloo College of Medicine, Shandong University, Linyi, 276000, Shandong, China.

Background: Radioactive iodine (RAI) therapy is an important treatment option for Graves' disease (GD), the main side effect of RAI treatment is hypothyroidism, and the factors resulting in hypothyroidism are still controversial. The purpose of this retrospective study was to clarify the possible risk factors of early hypothyroidism after RAI therapy in Graves' disease.

Methods: We reviewed 312 GD patients treated with RAI between January 2017 to December 2018, collected the potential risk factors, and analyzed the relationship between these variables and early hypothyroidism. Read More

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http://dx.doi.org/10.1186/s12902-020-00557-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260835PMC
May 2020
1.673 Impact Factor

Hepatic steatosis is associated with abnormal hepatic enzymes, visceral adiposity, altered myocardial glucose uptake measured by F-FDG PET/CT.

BMC Endocr Disord 2020 May 27;20(1):75. Epub 2020 May 27.

Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China.

Background: Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects the liver and a variety of extra-hepatic organ systems. This study aimed to investigate the relationship between hepatic steatosis and glucose metabolism in liver and extra-hepatic tissues and organs.

Methods: The whole body F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) images of 191 asymptomatic tumor screening patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s12902-020-00556-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254706PMC

Establishing a diagnostic scale of subacute thyroiditis without radioisotope scanning.

BMC Endocr Disord 2020 May 27;20(1):74. Epub 2020 May 27.

Department of Endocrinology, Yuebei People's Hospital, NO. 133 Huimin South Road, Shaoguan, Guangdong Province, China.

Background: Radioisotope scanning is important to diagnose subacute thyroiditis (SAT), but it's not always available. So we aim to establish a diagnostic scale for SAT without radioisotope scanning.

Methods: The suspected SAT patients hospitalized in Yuebei people's Hospital from January 2012 to December 2016 were selected and divided into study group and control group according to whether they were diagnosed as SAT. Read More

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http://dx.doi.org/10.1186/s12902-020-00554-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251828PMC
May 2020
1.673 Impact Factor

Report: central diabetes insipidus and schwannoma in a male with X-linked congenital adrenal hypoplasia.

BMC Endocr Disord 2020 May 27;20(1):73. Epub 2020 May 27.

Department of Pediatrics, Gyeongsang National University School of Medicine, 92 Chilam-dong, Jinju, Gyeongnam, 660-751, South Korea.

Background: DAX1 mutations are related to the X-linked form of adrenal hypoplasia congenita (AHC) in infancy and to hypogonadotropic hypogonadism (HH) in puberty. We report a male patient affected by X-linked AHC who presented with central diabetes insipidus and schwannoma in adulthood, which has not been described in association with AHC.

Case Presentation: A 36-day-old male infant who presented with severe dehydration was admitted to the intensive care unit. Read More

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http://dx.doi.org/10.1186/s12902-020-00553-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254651PMC

Diet-derived nutrient patterns and components of metabolic syndrome: a cross-sectional community- based study.

BMC Endocr Disord 2020 May 19;20(1):69. Epub 2020 May 19.

Tabriz Health Services Management Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Metabolic syndrome (MetS) is one of the main public health problems worldwide. Although some relations between dietary intakes and MetS have been found, few studies have focused on association between dietary nutrients interactions and the risk of the MetS and its components. The aim of the present study was to examine the association between nutrient patterns and MetS and its components among Iranian adult population. Read More

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http://dx.doi.org/10.1186/s12902-020-0547-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236137PMC
May 2020
1.673 Impact Factor

Emergency attendance for acute hyper- and hypoglycaemia in the adult diabetic population of the metropolitan area of Milan: quantifying the phenomenon and studying its predictors.

BMC Endocr Disord 2020 May 19;20(1):72. Epub 2020 May 19.

Epidemiology Unit, Agency for Health Protection (ATS) of Milan, C.so Italia, 19, 20122 Milano, Milan, (MI), Italy.

Background: We quantified, among diabetic adults, the frequency, costs, and factors associated with visits to the emergency department (EDs) and subsequent hospitalizations for acute hypoglycaemic and hyperglycaemic events.

Methods: We included adults with diabetes residing in the Milan Agency for Health Protection between 2015 and 2017. From healthcare databases, we identified demographic variables, comorbidities, type of treatment, insulin treatment duration, previous ED attendances for acute glycaemic events, and two indicators of glycaemic monitoring. Read More

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http://dx.doi.org/10.1186/s12902-020-0546-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238653PMC

Predictors of dopamine agonist resistance in prolactinoma patients.

BMC Endocr Disord 2020 May 19;20(1):68. Epub 2020 May 19.

Department of Neurosurgery, VUB University Hospital of Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium.

Background: Surgical resection of prolactinomas resistant to dopamine agonists is frequently incomplete due to fibrotic changes of the tumour under pharmacological therapy. In order to identify a subgroup of patients who may benefit from early surgery, we thought to investigate possible predictive factors of pharmacological resistance of prolactinomas to dopamine agonists.

Methods: We retrospectively analyzed a database of a Belgian tertiary reference center for patients with pituitary tumours from 2014 to 2016. Read More

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http://dx.doi.org/10.1186/s12902-020-0543-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236128PMC

Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome.

BMC Endocr Disord 2020 May 19;20(1):67. Epub 2020 May 19.

Department of Endocrinology, the Affiliated Hospital, Zunyi Medical University, Zunyi, 563003, Guizhou, China.

Background: Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent. Read More

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http://dx.doi.org/10.1186/s12902-020-0538-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236448PMC

Putative functional non-coding polymorphisms in SELP significantly modulate sP-selectin levels, arterial stiffness and type 2 diabetes mellitus susceptibility.

BMC Endocr Disord 2020 May 19;20(1):70. Epub 2020 May 19.

School of Medicine, Wayne State University, Detroit, Michigan, USA.

Background: P-selectin, encoded by SELP, has been implicated as an important molecule in the development of arterial stiffness, consequently leading to vascular complications in T2DM. SELP polymorphisms and increased levels of soluble P-selectin (sP-selectin) have been shown to be associated with several inflammatory diseases. The present work was designed to assess nine putative functional non-coding SELP variants in relation to sP-selectin levels and arterial stiffness in T2DM. Read More

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http://dx.doi.org/10.1186/s12902-020-00548-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236446PMC

Effect of lifestyle modifications on anthropometric, clinical, and biochemical parameters in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis.

BMC Endocr Disord 2020 May 19;20(1):71. Epub 2020 May 19.

Department of Midwifery and Reproductive Health Research Center, Department of Midwifery and Reproductive Health, School of Nursing and midwifery, Shahid Beheshti University of Medical Sciences, Cross of Vali-Asr and Neiaiesh Highway, Opposite to Rajaee Heart Hospital, Tehran, Postal Code: 1996835119, Iran.

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. This study aimed to compare the effects of lifestyle interventions on anthropometric, clinical, and biochemical parameters in adolescent girls with PCOS.

Methods: PubMed, Scopus, and Web of Science was systematically searched to retrieve studies investigating the effects of lifestyle modifications in adolescent girls with PCOS, which were published up to December 2019. Read More

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http://dx.doi.org/10.1186/s12902-020-00552-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236342PMC

Association of circulating CEACAM1 levels and insulin sensitivity in gestational diabetes mellitus.

BMC Endocr Disord 2020 May 15;20(1):66. Epub 2020 May 15.

Department of Endocrinology, Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, China.

Background: The aim of this study was to estimate the levels of circulating carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in subjects with gestational diabetes mellitus (GDM) and investigate the relationships between CEACAM1 and GDM.

Methods: Circulating CEACAM1 levels were measured by ELISA kit in 70 women with GDM and 70 normal glucose tolerance (NGT) pregnant women. Blood samples were collected to detect fasting plasma glucose (FPG), fasting insulin (FINS) and glycosylated hemoglobin (HbA1c) levels in all participants. Read More

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http://dx.doi.org/10.1186/s12902-020-00550-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227292PMC

Association of vitamin D and D with type 2 diabetes complications.

BMC Endocr Disord 2020 May 15;20(1):65. Epub 2020 May 15.

Weill Cornell Medicine-Qatar, PO Box 24144, Doha, Qatar.

Aims: Vitamin D measurement is a composite of vitamin D (25(OH)D) and D (25(OH)D) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D supplements. This study was undertaken to determine if vitamin D and D levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D and vitamin D levels in subjects with T2DM METHODS: Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D and D were measured by LC-MS/MS analysis. Read More

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http://dx.doi.org/10.1186/s12902-020-00549-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227254PMC
May 2020
1.673 Impact Factor

Chinese siblings with hereditary medullary thyroid carcinoma caused by RET mutation: implications for RET oncogene detection.

BMC Endocr Disord 2020 May 14;20(1):64. Epub 2020 May 14.

Department of Oncology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, No.1095 Jie Fang Avenue, Wuhan, 430030, Hubei, China.

Background: Hereditary medullary thyroid carcinoma (MTC) is mainly caused by germline mutations in the RET proto-oncogene, which accounts for 20-30% of all MTC according to foreign studies. However, no English literatures have reported Chinese hereditary MTC. Here, we reported two Chinese brothers with MTC that caused by germline RET mutation. Read More

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http://dx.doi.org/10.1186/s12902-020-0544-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222469PMC

Plasma adiponectin, visfatin, leptin, and resistin levels and the onset of colonic polyps in patients with prediabetes.

BMC Endocr Disord 2020 May 11;20(1):63. Epub 2020 May 11.

Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, 230032, Anhui Province, China.

Background: Prediabetes is associated with a high risk of colon cancer, and abdominal obesity, which can result in the secretion of several obesity-related adipocytokines, is an independent influencing factor for colonic polyps in prediabetes subjects. However, the correlation between adipocytokine levels and colonic polyps in prediabetes subjects is unclear. This research explores the relationship between plasma adiponectin, visfatin, leptin, and resistin levels and the development of colonic polyps in prediabetes subjects. Read More

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http://dx.doi.org/10.1186/s12902-020-0540-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216429PMC

Manifestations of left ventricular dysfunction and arrhythmia in patients with chronic hypoparathyroidism and pseudohypoparathyroidism: a preliminary study.

BMC Endocr Disord 2020 May 11;20(1):61. Epub 2020 May 11.

Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Dongcheng District, Shuaifuyuan No.1, Beijing, 100730, China.

Background: Cardiac damage triggered by severe hypocalcemia is well known. However, the role of chronic hypoparathyroidism (HP) and pseudohypoparathyroidism (PHP) in cardiac health is still unclear. We investigated the effect of chronic HP and PHP on cardiac structure and conductive function in patients compiling with treatment. Read More

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http://dx.doi.org/10.1186/s12902-020-0541-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216721PMC

A case of insulin-like growth factor 2-producing gastrointestinal stromal tumor with severe hypoglycemia.

BMC Endocr Disord 2020 May 11;20(1):60. Epub 2020 May 11.

Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan.

Background: Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome that secretes incompletely processed high molecular weight insulin growth factor 2 (big-IGF2), which results in stimulation of the insulin receptor and subsequently induces hypoglycemia. Gastrointestinal stromal tumor (GIST) is a common intestinal mesenchymal neoplasm of the gastrointestinal tract. The most frequent site of GIST is the stomach; NICTH induced by IGF2-producing stomach GISTs is rare. Read More

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http://dx.doi.org/10.1186/s12902-020-0529-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216505PMC

Pregnancy-induced Cushing's syndrome with an adrenocortical adenoma overexpressing LH/hCG receptors: a case report.

BMC Endocr Disord 2020 May 11;20(1):62. Epub 2020 May 11.

Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China.

Background: Pregnancy-induced Cushing's syndrome (CS) with an adrenocortical adenoma overexpressing luteinizing hormone (LH)/human choriogonadotropin (hCG) receptors (LHCGR) has been rarely reported in the literatures. This peculiar condition challenges the canonical diagnosis and management of CS.

Case Presentation: A 27-year-old woman (G2P0A1) presented at 20 weeks gestational age (GA) with overt Cushingoid clinical features. Read More

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http://dx.doi.org/10.1186/s12902-020-0539-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216527PMC
May 2020
1.673 Impact Factor

Dulaglutide improves glucocorticoid-induced hyperglycemia in inpatient care and reduces dose and injection frequency of insulin.

BMC Endocr Disord 2020 May 7;20(1):58. Epub 2020 May 7.

Department of Diabetes and Endocrinology, University of Yamanashi Hospital, 1110 Shimokato, Chuo, Yamanashi, 4093898, Japan.

Background: Glucocorticoid (GC)-induced hyperglycemia is characterized by elevated postprandial blood glucose, which commonly requires multiple insulin injections. We investigated whether a long-acting glucagon-like peptide-1 receptor agonist, dulaglutide (Dula), safely improved GC-induced hyperglycemia in inpatients, to reduce insulin injection frequency.

Methods: The data of hospitalized patients with GC-induced hyperglycemia treated with Dula (Dula group, n = 38) or without (non-Dula group, n = 38) were retrospectively evaluated. Read More

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http://dx.doi.org/10.1186/s12902-020-0542-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203793PMC

Influence of KISS1 gene polymorphisms on the risk of polycystic ovary syndrome and its associated variables, in Saudi women.

BMC Endocr Disord 2020 May 7;20(1):59. Epub 2020 May 7.

Central Laboratory, Female Center for Scientific and Medical Colleges, King Saud University, Riyadh, Saudi Arabia.

Background: Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder, affecting millions of women worldwide. The role of genetic polymorphisms of the KISS1 gene on the development of PCOS is still obscure. This study was designed to investigate the probable influence of KISS1 gene polymorphisms on PCOS and its associated variables: BMI, waist-hip ratio, kisspeptin, LH, FSH, and LH-FSH ratio. Read More

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http://dx.doi.org/10.1186/s12902-020-0537-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203813PMC
May 2020
1.673 Impact Factor

Feel4Diabetes healthy diet score: development and evaluation of clinical validity.

BMC Endocr Disord 2020 May 6;20(Suppl 2):46. Epub 2020 May 6.

Department of Public Health Solutions, National Institute for Health and Welfare, PO BOX 30, 00270, Helsinki, Finland.

Background: The aim of this paper is to present the development of the Feel4Diabetes Healthy Diet Score and to evaluate its clinical validity.

Methods: Study population consisted of 3268 adults (63% women) from high diabetes risk families living in 6 European countries. Participants filled in questionnaires at baseline and after 1 year, reflecting the dietary goals of the Feel4Diabetes intervention. Read More

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http://dx.doi.org/10.1186/s12902-020-0521-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201941PMC

Effective strategies for childhood obesity prevention via school based, family involved interventions: a critical review for the development of the Feel4Diabetes-study school based component.

BMC Endocr Disord 2020 May 6;20(Suppl 2):52. Epub 2020 May 6.

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El Venizelou Ave, 176 71 Kallithea, Athens, Greece.

Background: Although there are many interventions targeting childhood obesity prevention, only few have demonstrated positive results. The current review aimed to gather and evaluate available school-based intervention studies with family involvement targeting dietary, physical activity and sedentary behaviors among primary schoolchildren and their families, in order to identify the most effective strategies.

Methods: Studies published between 2000 and January 2015 were retrieved from scientific electronic databases and grey literature. Read More

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http://dx.doi.org/10.1186/s12902-020-0526-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201517PMC

Efficacy and safety of lanreotide autogel compared with lanreotide 40 mg prolonged release in Chinese patients with active acromegaly: results from a phase 3, prospective, randomized, and open-label study (LANTERN).

BMC Endocr Disord 2020 May 4;20(1):57. Epub 2020 May 4.

Peking Union Medical College Hospital, PUMCH, No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China.

Background: Lanreotide autogel is a somatostatin analog (SSA) approved for the treatment of acromegaly in 73 countries worldwide; however, it is not yet approved in China. The aim of this study was to evaluate the efficacy and safety of lanreotide autogel compared with lanreotide 40 mg prolonged release (PR) in Chinese patients with active acromegaly.

Methods: LANTERN was a phase 3, randomized, open-label, non-inferiority study. Read More

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http://dx.doi.org/10.1186/s12902-020-0524-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199333PMC

Development of a clinical decision tool to reduce diagnostic testing for primary aldosteronism in patients with difficult-to-control hypertension.

BMC Endocr Disord 2020 Apr 29;20(1):56. Epub 2020 Apr 29.

Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, 85500, 3508 GA, Utrecht, The Netherlands.

Background: Satisfactory tools to preclude low-risk patients from intensive diagnostic testing for primary aldosteronism (PA) are lacking. Therefore, we aimed to develop a decision tool to determine which patients with difficult-to-control hypertension have a low probability of PA, thereby limiting the exposure to invasive testing while at the same time increasing the efficiency of testing in the remaining patients.

Methods: Data from consecutive patients with difficult-to-control hypertension, analysed through a standardized diagnostic protocol between January 2010 and October 2017 (n = 824), were included in this cross-sectional study. Read More

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http://dx.doi.org/10.1186/s12902-020-0528-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191700PMC

Ten years with biosimilar rhGH in clinical practice in Sweden - experience from the prospective PATRO children and adult studies.

BMC Endocr Disord 2020 Apr 29;20(1):55. Epub 2020 Apr 29.

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Background: In 2007, Omnitrope® was the first biosimilar recombinant human growth hormone (rhGH) to be approved in Sweden for treatment in adults and children. Over 10 years' safety and effectiveness data for biosimilar rhGH can now be presented.

Methods: PATRO Children and PATRO Adults are multicenter, longitudinal, observational, post-marketing surveillance studies. Read More

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http://dx.doi.org/10.1186/s12902-020-0535-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191769PMC

Endocrine disorders after heart transplantation: national cohort study.

BMC Endocr Disord 2020 Apr 20;20(1):54. Epub 2020 Apr 20.

Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Background: Endocrine disorders in patients after heart transplantation (HT) remain understudied. We aimed to assess endocrine profiles and management of HT recipients in the early post- transplant period.

Methods: We conducted a retrospective cohort study on 123 consecutive HT recipients in the Advanced Heart Failure and Transplantation Programme between 2009 and 2018. Read More

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http://dx.doi.org/10.1186/s12902-020-0533-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171847PMC

Case report of a cystic parathyroidal adenoma with rapid growth induced by cinacalcet.

BMC Endocr Disord 2020 Apr 20;20(1):53. Epub 2020 Apr 20.

Clinic of Nuclear Medicine, Jena University Hospital, Jena, Germany.

Background: Primary hyperparathyroidism is a rare condition of disease which can seldomly present as giant retrotrhyroideal cysts, complicating the localization of the adenoma to resect.

Case Presentation: A 56-year old female presented with hypercalcaemia of 3.38 mmol/L (2. Read More

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http://dx.doi.org/10.1186/s12902-020-0532-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171747PMC

Growth hormone deficiency with late-onset hypothalamic hypoadrenocorticism associated with respiratory and renal dysfunction: a case report.

BMC Endocr Disord 2020 Apr 16;20(1):50. Epub 2020 Apr 16.

Department of Diabetes and Endocrine Medicine, Kagoshima University Graduate School of Medicine and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.

Background: The prevalence of childhood-onset growth hormone (GH) deficiency (GHD) is estimated to be approximately 1 in 5000 or more, with the cause unknown in most cases (idiopathic isolated GHD). However, additional disorders of secretion of other pituitary hormones reportedly develop over time, with a frequency of 2-94% (median, 16%). Furthermore, median times to development of other anterior pituitary hormone deficiencies have been reported to be 6. Read More

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http://dx.doi.org/10.1186/s12902-020-0536-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160895PMC