674 results match your criteria BMC Endocrine Disorders[Journal]


Time for a reassessment of the treatment of hypothyroidism.

BMC Endocr Disord 2019 Apr 18;19(1):37. Epub 2019 Apr 18.

, 113 Andersons Road, Yandina, QLD 4561, Australia.

Background: In the treatment for hypothyroidism, a historically symptom-orientated approach has given way to reliance on a single biochemical parameter, thyroid stimulating hormone (TSH).

Main Body: The historical developments and motivation leading to that decision and its potential implications are explored from pathophysiological, clinical and statistical viewpoints. An increasing frequency of hypothyroid-like complaints is noted in patients in the wake of this directional shift, together with relaxation of treatment targets. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-019-0365-4DOI Listing
April 2019
1 Read

Long-term outcomes and risk factors of thyroid dysfunction during pegylated interferon and ribavirin treatment in patients with chronic hepatitis C infection in Taiwan.

BMC Endocr Disord 2019 Apr 5;19(1):36. Epub 2019 Apr 5.

Department of Occupational Medicine, Tainan Municipal Hospital (managed by Show Chwan Medical Care Corporation), Tainan, Taiwan. No. 670, Chongde Road, East District, Tainan, Taiwan.

Background: This study aimed to investigate the occurrence and risk factors of thyroid dysfunction (TD) in patients with chronic hepatitis C (CHC) infection in Taiwan.

Methods: The data in this study were obtained from the Taiwan National Health Insurance Research (Taiwan NHIR) database between 2001 and 2013. CHC patients treated with pegylated interferon/ribavirin (PEG-IFN/RBV) were enrolled as case patients, and nontreated CHC patients were enrolled as controls and were matched at a control:case ratio of 3:1 by index date, age (± 3 years), and sex. Read More

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http://dx.doi.org/10.1186/s12902-019-0362-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451221PMC
April 2019
2 Reads

Adherence to antidiabetic medication and factors associated with non-adherence among patients with type-2 diabetes mellitus in two regional hospitals in Cameroon.

BMC Endocr Disord 2019 Apr 3;19(1):35. Epub 2019 Apr 3.

Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.

Background: Diabetes mellitus is a growing cause of disease burden globally. Its management is multifaceted, and adherence to pharmacotherapy is known to play a significant role in glycaemic control. Data on medication adherence among affected patients is unknown in Cameroon. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-019-0360-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446302PMC
April 2019
4 Reads

Type 1 diabetes-associated cognitive impairment and diabetic peripheral neuropathy in Chinese adults: results from a prospective cross-sectional study.

BMC Endocr Disord 2019 Mar 27;19(1):34. Epub 2019 Mar 27.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, China.

Background: To compare neurocognitive functioning of Type 1 diabetic mellitus (T1DM) and healthy adults, and explore risk factors of cognitive dysfunction of T1DM patients, especially the association between cognitive impairment and diabetic peripheral neuropathy (DPN).

Methods: Seventy T1DM (age: 32.17 ± 9. Read More

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http://dx.doi.org/10.1186/s12902-019-0359-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437981PMC
March 2019
1 Read

Endocrine Manifestations in POEMS Syndrome: a case report and literature review.

BMC Endocr Disord 2019 Mar 22;19(1):33. Epub 2019 Mar 22.

Department of Endocrine and Metabolism, Tianjin Medical University General Hospital, No.154, AnShan Road, HePing District, Tianjin, 300052, China.

Background: POEMS syndrome, a rare systemic disease, is characterized by 5 components: Peripheral neuropathy, Organomegaly, Endocrinopathy, M protein elevation, and Skin changes. It usually presents with multiplex endocrine manifestations and is easily misdiagnosed and incorrectly treated.

Case Presentation: We report herein a case of POEMS syndrome that initially presented as hyperpigmentation and severe pitting edema of the lower extremities. Read More

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http://dx.doi.org/10.1186/s12902-019-0355-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431048PMC
March 2019
3 Reads
1.673 Impact Factor

Plasma level of peroxiredoxin 3 in patients with polycystic ovarian syndrome.

BMC Endocr Disord 2019 Mar 14;19(1):32. Epub 2019 Mar 14.

Division of Immunology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.

Background: As a member of peroxiredoxin (PRX) family, PRX3 is predominantly located in mitochondria and plays an important role of free radical scavenging. Since a body of evidence demonstrated the involvement of PRX3 in insulin secretion, insulin sensitivity, and glucose metabolism, the present study was conducted to investigate the role of PRX3 in the pathogenesis of polycystic ovarian syndrome (PCOS) featured in insulin resistance.

Methods: Enzyme-linked immunosorbent assay was performed to detect plasma PRX3 in PCOS patients and control subjects. Read More

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http://dx.doi.org/10.1186/s12902-019-0358-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419434PMC
March 2019
1 Read

Genetic and epigenetic characteristics in ovarian tissues from polycystic ovary syndrome patients with irregular menstruation resemble those of ovarian cancer.

BMC Endocr Disord 2019 Mar 12;19(1):30. Epub 2019 Mar 12.

Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004, China.

Background: Irregular menstruation is clinically associated with an increased risk for ovarian cancer and disease-related mortality. This relationship remains poorly understood, and a mechanism explaining it has yet to be described.

Methods: Ovarian tissues from women with polycystic ovary syndrome (PCOS) and regular menstruation (n = 10) or irregular menstruation (n = 10) were subjected to DNA methylation sequencing, real-time PCR array, whole-exome sequencing, and bioinformatics analysis. Read More

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http://dx.doi.org/10.1186/s12902-019-0356-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416936PMC

Association between glycosylated hemoglobin A1c and bone biochemical markers in type 2 diabetic postmenopausal women: a cross-sectional study.

BMC Endocr Disord 2019 Mar 12;19(1):31. Epub 2019 Mar 12.

Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Anti-inflammatory and Immune Medicine innovation team, Hefei, 230032, China.

Background: type 2 diabetes mellitus (T2DM) is a complicated disease that can affect bone health, but the change in bone biochemical markers caused by T2DM was controversial, so the aim of this study was to investigate whether there was a discrepancy in the levels of bone biochemical markers between postmenopausal women with T2DM and non-diabetic women and to explore the relationship between the level of glycosylated hemoglobin A1c (HbA1c) and bone biochemical markers in these subjects.

Methods: A total of 237 type 2 diabetic postmenopausal women visiting the First Affiliated Hospital of Anhui Medical University from January 2017 to October 2018 and 93 healthy postmenopausal women were retrospectively enrolled. The differences in the levels of bone biochemical markers between patients and controls were analyzed by one-way ANOVA or chi-square test. Read More

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http://dx.doi.org/10.1186/s12902-019-0357-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416956PMC
March 2019
1 Read

Poor short-term glycemic control in patients with type 2 diabetes impairs the intestinal mucosal barrier: a prospective, single-center, observational study.

BMC Endocr Disord 2019 Mar 8;19(1):29. Epub 2019 Mar 8.

Department of Critical Care Medicine, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, No.1, Chengbei Rd, Jiading District, Shanghai, 201800, China.

Background: To determine the relation between daily glycemic fluturation and the intestinal mucosal barrier dysfunction in type 2 diabetes mellitus (T2DM).

Methods: Totally 66 patients with T2DM were enrolled, 33 healthy volunteers were also recruited according to the enrolled patients' gender and age in a ratio of 2: 1. Patients were bisected by the median of endotoxins level into low(< 12. Read More

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http://dx.doi.org/10.1186/s12902-019-0354-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408809PMC

Additive interaction of snoring and body mass index on the prevalence of metabolic syndrome among Chinese coal mine employees: a cross-sectional study.

BMC Endocr Disord 2019 Mar 4;19(1):28. Epub 2019 Mar 4.

Department of Health Statistics, School of Public Health, Shanxi Medical University, 56 Xinjiannanlu Street, Taiyuan, Shanxi, 030001, People's Republic of China.

Background: Although snoring has been previously reported to be associated with metabolic syndrome (MetS), its interaction with body mass index(BMI) on MetS remains unclear. We aimed to examine the individual effects and possible interaction between snoring and BMI on MetS.

Methods: From July 2013 to December 2013, 3794 employees of coal mining enterprises aged 18 to 65 were recruited from Shanxi province of China. Read More

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http://dx.doi.org/10.1186/s12902-019-0352-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399959PMC
March 2019
3 Reads
1.673 Impact Factor

Incidence and determinants of diabetes-related lower limb amputations in Ghana, 2010-2015- a retrospective cohort study.

BMC Endocr Disord 2019 Mar 1;19(1):27. Epub 2019 Mar 1.

Faculty of Medicine and Department of Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.

Background: Diabetes-related lower limb amputations (LLA) are associated with significant morbidity and mortality. Although the incidence has decreased over the past two decades in most High-Income Countries, the situation in Low-Middle Income Countries (LMIC), especially those in sub-Saharan Africa (SSA) is not clear. We have determined the incidence and determinants of diabetes-related LLA in Ghana. Read More

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http://dx.doi.org/10.1186/s12902-019-0353-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397489PMC
March 2019
1 Read

Late-onset isolated adrenocorticotropic hormone deficiency caused by nivolumab: a case report.

BMC Endocr Disord 2019 Feb 19;19(1):25. Epub 2019 Feb 19.

Internal Medicine 1, Shimane University Faculty of Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan.

Background: Immune checkpoint inhibitors including nivolumab, an anti-programmed cell death protein 1 antibody, are recently developed cancer immunotherapy agents. Immune checkpoint inhibitors are known to cause autoimmune-related side effects including endocrine dysfunctions. However, there are few reports on late-onset isolated adrenocorticotropic hormone (ACTH) deficiency caused by nivolumab. Read More

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http://dx.doi.org/10.1186/s12902-019-0335-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381704PMC
February 2019
1 Read

Trend of various adiposity indices in women with and without history of gestational diabetes: a population-based cohort study.

BMC Endocr Disord 2019 Feb 19;19(1):24. Epub 2019 Feb 19.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24, Parvane Street, Yaman Street, Velenjak, Tehran, Iran.

Background: Data of studies focusing on the trends of adiposity indices among women with prior gestational diabetes mellitus (GDM), are limited and controversial. The aim of this study was to compare overtime trends of adiposity indices in women with and without history of GDM, using data of the long term longitudinal population-based Tehran-Lipid and Glucose-Study (TLGS).

Methods: A total of 3395 eligible women aged (20-50 years), including 801 women with prior history of GDM and 2594 non-GDM controls were recruited from among Tehran-Lipid and Glucose-Study participants. Read More

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http://dx.doi.org/10.1186/s12902-019-0348-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381680PMC
February 2019

Performance of HbA1c versus oral glucose tolerance test (OGTT) as a screening tool to diagnose dysglycemic status in high-risk Thai patients.

BMC Endocr Disord 2019 Feb 15;19(1):23. Epub 2019 Feb 15.

Diabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.

Background: Dysglycemic status defined by prediabetes and diabetes is known to be related with future risk of diabetic complications and cardiovascular diseases. Herein, we aimed to determine the diagnostic accuracy of glycated hemoglobin (HbA1c) when compared with oral glucose tolerance test (OGTT) as a reference test in identifying dysglycemic status among high-risk Thai patients receiving care in an out-patient setting.

Methods: An 11-year retrospective cross-sectional study of high-risk Thai patients who underwent OGTT during 2007-2017 was analysed. Read More

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http://dx.doi.org/10.1186/s12902-019-0339-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377733PMC
February 2019
1 Read

Frequency and risk factors for recurrent gestational diabetes mellitus in primiparous women: a case control study.

BMC Endocr Disord 2019 Feb 15;19(1):22. Epub 2019 Feb 15.

The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, No. 1961, Huashan Road, Shanghai, 200030, China.

Background: To investigate the frequency and risk factors for recurrent gestational diabetes mellitus (GDM) in Chinese primiparous women.

Methods: Case control study. We investigated primiparous women who experienced GDM complications and had a subsequent pregnancy in the same hospital from January, 2012 to January, 2017. Read More

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http://dx.doi.org/10.1186/s12902-019-0349-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377747PMC
February 2019
1 Read

Mobile health in the management of type 1 diabetes: a systematic review and meta-analysis.

BMC Endocr Disord 2019 Feb 13;19(1):21. Epub 2019 Feb 13.

Department of Health Statistics, School of Public Health, Inner Mongolia Medical University, Hohhot, 010110, China.

Background: As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However, the effectiveness of mHealth in controlling the glycemic control remains uncertain. Read More

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http://dx.doi.org/10.1186/s12902-019-0347-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375163PMC
February 2019

Preventing misdiagnosis of diabetes in the elderly: age-dependent HbA1c reference intervals derived from two population-based study cohorts.

BMC Endocr Disord 2019 Feb 12;19(1):20. Epub 2019 Feb 12.

Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany.

Background: Measurement of gylcated hemoglobin A1c (HbA1c) plays a central role in monitoring quality of antidiabetic therapy and in the diagnosis of diabetes. Several studies report increased levels of HbA1c in nondiabetic elderly. However, this observation did not reach incorporation into daily clinical practice or the respective guidelines. Read More

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http://dx.doi.org/10.1186/s12902-019-0338-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371438PMC
February 2019
1 Read

The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism.

BMC Endocr Disord 2019 Feb 8;19(1):19. Epub 2019 Feb 8.

Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) proteins have an important role in counteracting oxidative stress. Although diabetes and hypothyroidism (HT) are both characterized by oxidative stress, the mechanisms are not fully understood. This study investigated the effects of type 1 diabetes (T1D), type 2 diabetes (T2D), and HT on the expression levels of SIRT1, SIRT3, and manganese superoxide dismutase (SOD2). Read More

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http://dx.doi.org/10.1186/s12902-019-0350-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368800PMC
February 2019
1 Read

Patterns and trends of utilization of incretin-based medicines between 2008 and 2014 in three Italian geographic areas.

BMC Endocr Disord 2019 Feb 7;19(1):18. Epub 2019 Feb 7.

Epidemiology Unit, Agenzia regionale di sanità della Toscana, Florence, Italy.

Background: The incretin-based medicines GLP1 analogues (GLP1a) and dipeptidyl peptidase-4 inhibitors (DPP4i) are hypoglycaemic agents licensed for the treatment of type 2 diabetes mellitus (T2DM). Although these drugs possess comparable efficacy and low risk of hypoglycaemia, differences in terms of route of administration (subcutaneous versus oral), effect on body weight and gastrointestinal tolerabily can impact their actual use in clinical practice. This study aimed to describe the real-world utilization of incretin-based medicines in the Italian clinical practice. Read More

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http://dx.doi.org/10.1186/s12902-019-0334-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367760PMC
February 2019
8 Reads

Self-reported hypoglycemia in adult diabetic patients in East Gojjam, Northwest Ethiopia: institution based cross-sectional study.

BMC Endocr Disord 2019 Jan 30;19(1):17. Epub 2019 Jan 30.

Department of Nursing, College of Medicine and Health Sciences, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia.

Background: Hypoglycemia presents a barrier to optimum diabetes management and it is related to a negative impact on health-related quality of life, healthcare resource use, and work productivity. Despite the fact that the magnitude of hypoglycemia and factors associated with hypoglycemia in diabetic population were demonstrated in clinical trial settings; there is no adequate evidence concerning to the problem in real-world settings, in particular in the study area. The aim of the study was to assess the magnitude of hypoglycemia and factors associated with hypoglycemia among adult diabetic patients attending chronic follow up clinic at Debre Markos referral hospital, East Gojjam Zone, Northwest Ethiopia, 2017. Read More

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http://dx.doi.org/10.1186/s12902-019-0341-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354379PMC
January 2019
3 Reads
1.673 Impact Factor

Recurrent tertiary hyperparathyroidism due to supernumerary parathyroid glands in a patient receiving long-term hemodialysis: a case report.

BMC Endocr Disord 2019 Jan 28;19(1):16. Epub 2019 Jan 28.

Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, 539 Chung Hsiao Rd, Chiayi, 600, Taiwan.

Background: Renal hyperparathyroidism is a common complication of chronic kidney disease (CKD) or end-stage renal disease (ESRD) characterized by elevated parathyroid hormone levels secondary to derangements in the homeostasis of calcium, phosphate, and vitamin D. Rapid correction of severe and prolonged hyperparathyroidism by surgical parathyroidectomy in long-term hemodialysis patients occasionally causes hungry bone syndrome. These patients then exhibit severe and long-lasting secondary or tertiary hyperparathyroidism with high bone turnover. Read More

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http://dx.doi.org/10.1186/s12902-019-0346-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350335PMC
January 2019
2 Reads
1.673 Impact Factor

11β Hydroxysteroid dehydrogenase - 1 activity in type 2 diabetes mellitus: a comparative study.

BMC Endocr Disord 2019 Jan 24;19(1):15. Epub 2019 Jan 24.

Medical College Kolkata, Kolkata, India.

Background: A comparative study of 11 β HSD 1 activity in type 2 diabetes mellitus subjects with respect to fasting blood glucose and other metabolic parameters was conducted.

Methods: A case control experimental study was performed enrolling thirty type 2 diabetes mellitus patients and thirty age, gender and BMI matched controls using cortisone acetate test.

Results: The rise of serum cortisol after oral 25 mg cortisone acetate from baseline (dexamethasone suppressed level) is higher in subjects with type 2 diabetes and is associated with exercise, BMI, SGOT but not daily calorie intake, lipid parameters and thyroid status. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s12902-019-0344-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345010PMC
January 2019
9 Reads

A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman.

BMC Endocr Disord 2019 Jan 23;19(1):14. Epub 2019 Jan 23.

Department of Endocrinology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, Hangzhou, China.

Background: Hyperandrogenemia is more common in puberty and reproductive age, but relatively rare in postmenopausal women. Postmenopausal virilization may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and are diagnosed as adrenocortical carcinoma, most of which can co-secrete androgen and cortisol. Read More

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http://dx.doi.org/10.1186/s12902-019-0342-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343319PMC
January 2019
2 Reads

Serum zinc-α2-glycoprotein levels are elevated and correlated with thyroid hormone in newly diagnosed hyperthyroidism.

BMC Endocr Disord 2019 Jan 22;19(1):12. Epub 2019 Jan 22.

Department of Metabolism and Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, 421001, China.

Background: Zinc-α2-glycoprotein (ZAG) is a recently novel lipolytic adipokine implicated in regulation of glucose and lipid metabolism in many metabolic disorders. In vitro and animal studies suggest that thyroid hormones (TH) up-regulates ZAG production in hepatocytes. However, there is no data evaluating the possible relationship between ZAG and TH in a human model of hyperthyroidism. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-019-0336-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343254PMC
January 2019
6 Reads
1.673 Impact Factor

A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.

BMC Endocr Disord 2019 Jan 22;19(1):13. Epub 2019 Jan 22.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. Here, we describe the first case of subclinical Cushing's syndrome represented by autonomous cortisol secretion and paradoxical response to oral dexamethasone administration, harboring an activating mutation in the α subunit of the stimulatory G protein (GNAS).

Case Presentation: A 65-year-old woman was diagnosed with subclinical Cushing's syndrome during an evaluation for bilateral adrenal masses. Read More

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http://dx.doi.org/10.1186/s12902-019-0345-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343241PMC
January 2019
2 Reads

Plasma glucose in screening for diabetes and pre-diabetes: how much is too much? Analysis of fasting plasma glucose and oral glucose tolerance test in Sri Lankans.

BMC Endocr Disord 2019 Jan 22;19(1):11. Epub 2019 Jan 22.

Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, London, UK.

Background: Fasting plasma glucose (FPG) is the most commonly used screening tool for diabetes in Sri Lanka. Cut-off values from American Diabetes Association recommendations are adopted in the absence of local data. We aimed to establish FPG cut offs for Sri Lankans to screen for diabetes and pre-diabetes. Read More

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http://dx.doi.org/10.1186/s12902-019-0343-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341544PMC
January 2019

Efficacy of Tc-DTPA SPECT/CT in diagnosing Orbitopathy in graves' disease.

BMC Endocr Disord 2019 Jan 18;19(1):10. Epub 2019 Jan 18.

Department of Nuclear Medicine, Medical University of Bialystok, M. Skłodowskiej-Curie St. 24A, 15-276, Bialystok, Poland.

Background: The most frequently used methods of assessing Graves' orbithopathy (GO) include: Clinical Activity Score (CAS), ultrasonography (USG), computed tomography (CT), and magnetic resonance imaging (MRI). There exists another, slightly forgotten, imaging method: single-photon emission computed tomography (SPECT) with the use of diethylenetriaminepentaacetic acid tagged with Tc (Tc-DTPA). These days it is possible to conduct a SPECT examination fused with a CT scan (SPECT/CT), which increases the diagnostic value of the investigation. Read More

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http://dx.doi.org/10.1186/s12902-019-0340-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339418PMC
January 2019
5 Reads

Adrenarche and pubarche in girls with turner syndrome during growth-promoting therapy with human growth hormone.

BMC Endocr Disord 2019 Jan 18;19(1). Epub 2019 Jan 18.

Paediatric Endocrinology, University Hospital of Erlangen, Loschgestr. 15, 91054, Erlangen, Germany.

Background: Data on adrenarche and pubarche in girls with Turner syndrome (TS) are inconsistent in the literature.

Methods: The cohort consisted of 94 girls and young women with TS born between 1971 and 2001 (age range: 3.1-23. Read More

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http://dx.doi.org/10.1186/s12902-019-0333-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339350PMC
January 2019
2 Reads

Vitamin-D2 treatment-associated decrease in 25(OH)D3 level is a reciprocal phenomenon: a randomized controlled trial.

BMC Endocr Disord 2019 Jan 18;19(1). Epub 2019 Jan 18.

Department King Faisal Specialist Hospital and Research Center, Clinical Studies and Empirical Ethics, P O Box # 3354, Riyadh, 11211, Saudi Arabia.

Background: Vitamin-D2 (D2) treatment has been associated with a decrease in 25-hydroxy (25(OH)) vitamin-D3 (D3) level, suggesting that D3 treatment would be preferred to raise total 25(OH) vitamin-D (D) level. We postulated that D2 treatment-associated decrease in 25(OH)D3 level is related to the increase in 25(OH)D level rather than being D2-specific, and thus there would be a similar D3 treatment-associated decrease in 25(OH)D2 level.

Methods: Fifty volunteers were block-randomized to 50,000 IU D2 or placebo orally once (study-1) and fifty volunteers received 50,000 IU D2 orally once and 4 days later block-randomized to 50,000 IU D3 or placebo orally once (study-2). Read More

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http://dx.doi.org/10.1186/s12902-019-0337-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339397PMC
January 2019
1 Read

Impact of technology-based interventions for children and young people with type 1 diabetes on key diabetes self-management behaviours and prerequisites: a systematic review.

BMC Endocr Disord 2019 Jan 10;19(1). Epub 2019 Jan 10.

University of Nottingham, School of Health Sciences, Nottingham, UK.

Background: The role of technology in the self-management of type 1 diabetes mellitus (T1DM) among children and young people is not well understood. Interventions should aim to improve key diabetes self-management behaviours (self-management of blood glucose, insulin administration, physical activity and dietary behaviours) and prerequisites (psychological outcomes and HbA1c) highlighted in the UK guidelines of the National Institute for Health and Care Excellence (NICE) for management of T1DM. The purpose was to identify evidence to assess the effectiveness of technological tools in promoting aspects of these guidelines amongst children and young people. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0331-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329145PMC
January 2019
13 Reads

Whole-body vibration improves the functional parameters of individuals with metabolic syndrome: an exploratory study.

BMC Endocr Disord 2019 Jan 9;19(1). Epub 2019 Jan 9.

Laboratório de Vibrações Mecânicas e Práticas Integrativas, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcântara Gomes e Policlínica Américo Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, fundos, 4° andar, Rio de Janeiro, RJ, 20551031, Brazil.

Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increases the cardiovascular risk. Regular physical exercise can promote benefits, but the MetS individuals are demotivated to perform it. Thus, new possibilities are important as an alternative intervention. Read More

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http://dx.doi.org/10.1186/s12902-018-0329-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325843PMC
January 2019
5 Reads
1.673 Impact Factor

Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report.

BMC Endocr Disord 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Diabetes and Metabolism, Tohoku University Hospital, 2-1 Seiryo, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Background: Insulin injection, especially with insulin analogs, occasionally induces the production of insulin antibodies with high binding capacity and low affinity, similar to the insulin autoantibodies characteristic of insulin autoimmune syndrome (IAS). Production of these "IAS-like" insulin antibodies causes marked glycemic fluctuations with postprandial hyperglycemia and fasting hypoglycemia.

Case Presentation: A 66-year-old man with a 27-year history of diabetes was admitted because of marked glycemic fluctuations. Read More

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http://dx.doi.org/10.1186/s12902-018-0326-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325663PMC
January 2019
3 Reads

Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials.

BMC Endocr Disord 2019 Jan 7;19(1). Epub 2019 Jan 7.

Civil Aviation General Hospital, Peking University, Beijing, China.

Background: Several clinical trials have studied the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on glycometabolism and cardiovascular risk factors since they were identified. Because of their cardiovascular benefits and efficacy in lowering glucose, GLP-1RAs are becoming increasingly important in clinical therapy for patients with or without pathoglycaemia. The aim of this study was to assess the effect of the GLP-1RA liraglutide on blood pressure based on randomised controlled trials (RCTs). Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0332-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323665PMC
January 2019
12 Reads

All-cause mortality of insulin plus dipeptidyl peptidase-4 inhibitors in persons with type 2 diabetes.

BMC Endocr Disord 2019 Jan 5;19(1). Epub 2019 Jan 5.

Institute of Population Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan Township, Miaoli County, 35053, Taiwan.

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors could effectively reduce HbA and postprandial hyperglycemia and could incur only minimal danger of hypoglycemia. Patients with uncontrolled diabetes might be treated by the complementary action of insulin plus DPP-4 inhibitors. Here, we compared the all-cause mortality risk between DPP-4 inhibitor users and nonusers with underlying insulin therapy. Read More

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http://dx.doi.org/10.1186/s12902-018-0330-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321656PMC
January 2019
15 Reads

Impact of diabetes mellitus on functional exercise capacity and pulmonary functions in patients with diabetes and healthy persons.

BMC Endocr Disord 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Pulmonology and Allergology, Faculty of Medicine, Medical University of Gdansk, Dębinki 7, 80-211, Gdańsk, Poland.

Background: Chronic diabetic complications may afflict all organ tissues, including those of the respiratory system. The six-minute walk test (6MWT) is an alternative and widely used method of assessing functional capacity and is simple to perform. However, to our knowledge, the impact of diabetes mellitus on 6MWT performance has not been investigated previously. Read More

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http://dx.doi.org/10.1186/s12902-018-0328-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318966PMC
January 2019
2 Reads

Mortality in patients with diabetic foot ulcer: a retrospective study of 513 cases from a single Centre in the Northern Territory of Australia.

BMC Endocr Disord 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Endocrinology, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Background: Diabetic foot ulcers (DFU) are a common problem in longstanding diabetes. However, mortality outcomes in Australian patients with DFU are still unclear.

Methods: All patients with DFU presenting for the first time to the Multi-Disciplinary Foot Clinic (MDFC) at Royal Darwin Hospital, Northern Territory Australia, between January 2003 and June 2015 were included in this study. Read More

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http://dx.doi.org/10.1186/s12902-018-0327-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318899PMC
January 2019
3 Reads

A case of malignant insulinoma responsive to somatostatin analogs treatment.

BMC Endocr Disord 2018 Dec 27;18(1):98. Epub 2018 Dec 27.

Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Careggi University Hospital, Florence, Italy.

Background: Insulinoma is a rare tumour representing 1-2% of all pancreatic neoplasms and it is malignant in only 10% of cases. Locoregional invasion or metastases define malignancy, whereas the dimension (> 2 cm), CK19 status, the tumor staging and grading (Ki67 > 2%), and the age of onset (> 50 years) can be considered elements of suspect.

Case Presentation: We describe the case of a 68-year-old man presenting symptoms compatible with hypoglycemia. Read More

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http://dx.doi.org/10.1186/s12902-018-0325-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307122PMC
December 2018
3 Reads

Retrospective assessment of the quality of diabetes care in a rural diabetes clinic in Western Kenya.

BMC Endocr Disord 2018 Dec 27;18(1):97. Epub 2018 Dec 27.

Moi University School of Medicine, Nandi Hills Road, Eldoret, 30100, Kenya.

Background: Sub-Saharan Africa continues to face the highest rate of mortality from diabetes in the world due to limited access to quality diabetes care. We assessed the quality of diabetes care in a rural diabetes clinic in western Kenya.

Methods: To provide a comprehensive assessment, a set of clinical outcomes, process, and structure metrics were evaluated to assess the quality of diabetes care provided in the outpatient clinic at Webuye District Hospital. Read More

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http://dx.doi.org/10.1186/s12902-018-0324-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307239PMC
December 2018
4 Reads

Obese adolescents exhibit a constant ratio of GH isoforms after whole body vibration and maximal voluntary contractions.

BMC Endocr Disord 2018 Dec 27;18(1):96. Epub 2018 Dec 27.

Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Verbania, Italy.

Background: Growth hormone (GH) is a heterogeneous protein composed of several molecular isoforms, the most abundant ones being the 22 kDa- and 20 kDa-GH. Exercise-induced secretion of GH isoforms has been extensively investigated in normal-weight individuals due to antidoping purposes, particularly recombinant human GH (rhGH) abuse. On the other hand, the evaluation of exercise-induced responses in GH isoforms has never been performed in obese subjects. Read More

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http://dx.doi.org/10.1186/s12902-018-0323-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307112PMC
December 2018
1 Read

Association between random glucose and all-cause mortality: findings from the mortality follow-up of the German National Health Interview and Examination Survey 1998.

BMC Endocr Disord 2018 Dec 13;18(1):95. Epub 2018 Dec 13.

Department of Epidemiology and Health Monitoring, Robert Koch Institute, General-Pape-Strasse 62-66, D-12101, Berlin, Germany.

Background: Random glucose is widely measured in epidemiological studies and in the clinical setting when standardized fasting protocols and oral glucose tolerance testing or HbA measuring are not feasible. The relationship between random glucose and all-cause mortality has hardly been studied so far and was examined in the present study.

Methods: We ascertained mortality status among 5955 persons aged 18-79 years and free of known diabetes when participating in the German National Health Interview and Examination Survey 1998 (mean observation time 11. Read More

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http://dx.doi.org/10.1186/s12902-018-0319-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293613PMC
December 2018
1 Read

Radioiodine treatment for graves' disease: a 10-year Australian cohort study.

BMC Endocr Disord 2018 Dec 12;18(1):94. Epub 2018 Dec 12.

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Background: Radioactive iodine (I) is a common definitive treatment for Graves' Disease. Potential complications include worsening, or new development of Graves' eye disease and development of a radiation thyroiditis. The purpose of the present study was to assess outcomes of patients treated with I in an Australian tertiary centre over 10 years. Read More

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http://dx.doi.org/10.1186/s12902-018-0322-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292026PMC
December 2018
1 Read

Investigation and management of moderate to severe inpatient hyponatraemia in an Australian tertiary hospital.

BMC Endocr Disord 2018 Dec 6;18(1):93. Epub 2018 Dec 6.

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba, Brisbane, QLD, 4102, Australia.

Background: Hyponatraemia is the most common electrolyte disturbance amongst hospitalised patients. Both American and European guidelines recommend fluid restriction as first line treatment for SIADH, however differ on second line recommendations. The objective of this study was to examine investigation and management of hyponatraemia in hospitalised patients in an Australian tertiary hospital. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0320-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282347PMC
December 2018
13 Reads

Clinical Management of Malignant Insulinoma: a single Institution's experience over three decades.

BMC Endocr Disord 2018 Dec 6;18(1):92. Epub 2018 Dec 6.

Department of Endocrinology, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, China.

Background: Malignant insulinoma is extremely rare and accounts for only 10% of total insulinoma cases. The goal of this study is to retrospectively analyze clinical data from 15 patients with malignant insulinoma treated at Peking Union Medical College Hospital (PUMCH) from 1984 to April 2017.

Methods: "Malignant insulinoma" was used as the keywords in the PUMCH medical record retrieval system to search and obtain patients' clinical information. Read More

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http://dx.doi.org/10.1186/s12902-018-0321-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282250PMC
December 2018
3 Reads

Pre-diabetes and diabetes are independently associated with adverse cognitive test results: a cross-sectional, population-based study.

BMC Endocr Disord 2018 Dec 4;18(1):91. Epub 2018 Dec 4.

Department of Acute Internal Medicine and Geriatrics, Linköping University, S-581 85, Linköping, Sweden.

Background: Diabetes is a risk factor for cognitive impairment, but whether there is also a link between pre-diabetes and cognitive dysfunction is not yet fully established. The aim of this observational study was to investigate associations between pre-diabetes/diabetes and cognitive test results, and also between glucose levels measured during the Oral Glucose Tolerance Test (OGTT) and cognitive outcomes.

Methods: During 2007-2012, in all 2994 people (mean age 72 years), residing in Malmö, Sweden, underwent a clinical examination including the OGTT, cardiovascular measurements including carotid-femoral pulse wave velocity (c-f PWV) and two cognitive tests, the Mini Mental State Examination (MMSE), measuring global cognitive function, and A Quick Test of Cognitive Speed (AQT), measuring processing speed and executive functioning. Read More

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http://dx.doi.org/10.1186/s12902-018-0318-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278035PMC
December 2018
2 Reads

Cardiovascular risk reduction over time in patients with diabetes or pre-diabetes undergoing bariatric surgery: data from a single-center retrospective observational study.

BMC Endocr Disord 2018 Nov 28;18(1):90. Epub 2018 Nov 28.

Departamento de Endocrinología y Nutrición, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Background: Bariatric surgery is effective in remission of obesity comorbidities. This study was aimed at comparing CVD risk between morbidly obese patients with type 2 diabetes and pre-diabetes before and after bariatric surgery as well as assessing comorbidities.

Methods: This is a retrospective observational study with 105 patients with type 2 diabetes (DMbaseline) and prediabetes (preDMbaseline) who underwent Roux-en-Y gastric bypass. Read More

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http://dx.doi.org/10.1186/s12902-018-0317-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263178PMC
November 2018
1 Read

Analysis of influencing factor of coexisting prediabetes and prehypertension in adult residents of Jilin Province.

BMC Endocr Disord 2018 Nov 26;18(1):89. Epub 2018 Nov 26.

Epidemiology and Statistics, School of Public Health, Jilin University, Changchun, 130021, China.

Background: To explore the risk factors of coexisting prediabetes and prehypertension, to provide theoretical basis for early intervention.

Methods: A multi-stage stratified random cluster sampling method was used to randomly select adult residents from Jilin Province in 2013 for questionnaire surveys, physical examinations, and laboratory tests.

Results: The prevalence of coexisting prediabetes and prehypertension in Jilin Province was 11. Read More

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http://dx.doi.org/10.1186/s12902-018-0316-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258491PMC
November 2018
1 Read

Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis.

BMC Endocr Disord 2018 Nov 26;18(1):87. Epub 2018 Nov 26.

Department of Emergency, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China.

Background: Cognitive impairment is commonly observed in patients with Hashimoto thyroiditis (HT). Low levels of vitamin D have been correlated with cognitive impairment in non-HT population. We examined the association of vitamin D levels with cognitive impairment in patients with HT. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0314-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260768PMC
November 2018
17 Reads

Treatment with PBI-4050 in patients with Alström syndrome: study protocol for a phase 2, single-Centre, single-arm, open-label trial.

BMC Endocr Disord 2018 Nov 26;18(1):88. Epub 2018 Nov 26.

Centre for Rare Disease, Department of Inherited Metabolic Disorders, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, B15 2TH, UK.

Background: Alström syndrome (ALMS) is a very rare autosomal recessive monogenic disorder caused by a mutation in the ALMS1 gene and characterised by childhood onset obesity, dyslipidaemia, advanced non-alcoholic fatty liver disease, diabetes and extreme insulin resistance. There is evidence of multi-organ fibrosis in ALMS and severity of the disease often leads to organ failure with associated morbidities, resulting in reduced life expectancy. There are no specific treatments for this disease, and current management consists of only symptomatic therapies. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0315-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258144PMC
November 2018
9 Reads

Assisted reproductive techniques with congenital hypogonadotropic hypogonadism patients: a systematic review and meta-analysis.

BMC Endocr Disord 2018 Nov 19;18(1):85. Epub 2018 Nov 19.

Key laboratory of Endocrinology, Ministry of Health; Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Wang Fu Jing St, Dongcheng district, Beijing, 100730, China.

Background: After hormonal replacement therapy (HRT) including androgen replacement or sequential therapy of estrogen and progesterone, The combination of human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) and pulsatile GnRH, is not sufficient to produce sufficient gametes in some patients with Congenital hypogonadotropic hypogonadism (CHH). A Systematic review and meta-analysis was performed to determine that assisted reproductive techniques (ART) can effectively treat different causes of infertility.

Methods: To determine the effect of ART on fertility of CHH patients and investigate whether outcomes are similar to infertility due to other causes, we conducted a systematic review and meta-analysis of retrospective trials. Read More

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http://dx.doi.org/10.1186/s12902-018-0313-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245556PMC
November 2018
3 Reads
1.673 Impact Factor

Usefulness of core needle biopsy for the diagnosis of thyroid Burkitt's lymphoma: a case report and review of the literature.

BMC Endocr Disord 2018 Nov 19;18(1):86. Epub 2018 Nov 19.

Department of Medical Surgical and Health Sciences, Università degli Studi di Trieste, Cattinara Teaching Hospital, Strada di Fiume 447, 34149, Trieste, Italy.

Background: Thyroid lymphomas are an exceptional finding in patients with thyroid nodules. Burkitt's lymphoma is one of the rarest and most aggressive forms of thyroid lymphomas, and its prognosis depends on the earliness of medical treatment. Given the rarity of this disease, making a prompt diagnosis can be challenging. Read More

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http://dx.doi.org/10.1186/s12902-018-0312-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245622PMC
November 2018
3 Reads