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    533 results match your criteria BMC Endocrine Disorders[Journal]

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    In-patient Tolvaptan use in SIADH: care audit, therapy observation and outcome analysis.
    BMC Endocr Disord 2017 Nov 6;17(1):69. Epub 2017 Nov 6.
    Department of Endocrinology & Diabetes, Queen Alexandra Hospital Portsmouth, Portsmouth, PO6 3LY, UK.
    Background: Indications for use of tolvaptan in SIADH-associated hyponatraemia remain controversial. We audited our local guidelines for Tolvaptan use in this situation to review treatment implications including drug safety, hospital admission episode analysis (episodes of liver toxicity, CNS myelinolysis, sodium-related re-admission rates), morbidity; mortality and underlying aetiologies.

    Methods: We report a retrospective case series analysis of on-going treatment outcomes (case-note review) for 31 patients (age 73. Read More

    A randomized, placebo-controlled clinical trial evaluating the safety and efficacy of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus inadequately controlled by glimepiride and metformin.
    BMC Endocr Disord 2017 Nov 6;17(1):70. Epub 2017 Nov 6.
    Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA.
    Background: Type 2 diabetes (T2D) is a progressive disease that often requires a patient to use multiple antihyperglycemic agents to achieve glycemic control with disease progression. Omarigliptin is a once-weekly dipeptidyl peptidase-4 inhibitor. The purpose of this trial was to assess the efficacy and safety of adding omarigliptin to the treatment regimen of patients with T2D inadequately controlled by dual therapy with metformin and glimepiride. Read More

    Serum vaspin concentration in elderly patients with type 2 diabetes mellitus and macrovascular complications.
    BMC Endocr Disord 2017 Oct 24;17(1):67. Epub 2017 Oct 24.
    Department of Cardiology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
    Background: Adipose tissue, an endocrine organ of the body, is involved in some obesity-related disease states such as insulin resistance, diabetes mellitus, and atherosclerosis. Vaspin is a novel adipocyte with insulin sensitizing effects. In this study, we planned to estimate serum vaspin concentrations as related to glycemic status and the presence of macrovascular complications among elderly patients with type-2 diabetes mellitus (T2DM). Read More

    Effectiveness and safety of exenatide in Korean patients with type 2 diabetes inadequately controlled with oral hypoglycemic agents: an observational study in a real clinical practice.
    BMC Endocr Disord 2017 Oct 25;17(1):68. Epub 2017 Oct 25.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-Ro, Seoul, Seodaemun-Gu, 03722, South Korea.
    Background: Randomized clinical trials have shown the efficacy and safety of short-acting exenatide in patients with type 2 diabetes mellitus (T2DM). The aim of this observational study was to investigate the effectiveness and safety of exenatide twice a day in Korean patients with T2DM who are suboptimally controlled with oral hypoglycemic agents.

    Methods: This study was a post hoc analysis of multi-center (71 centers), prospective, observational, single-arm, post-marketing study of short-acting exenatide 5 to 10 μg twice a day from March 2008 to March 2014 and analyzed those who finished the follow-up over 20 weeks of medication. Read More

    Thyroid function and metabolic syndrome in the population-based LifeLines cohort study.
    BMC Endocr Disord 2017 Oct 16;17(1):65. Epub 2017 Oct 16.
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, HPC AA31, P.O. Box 30001, 9700 RB, Groningen, The Netherlands.
    Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors which includes abdominal obesity, dyslipidaemia, elevated blood pressure and impaired fasting glucose. Earlier studies have reported a relationship between thyroid function and some MetS components or suggested that serum free thyroxine (FT4) or free triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to MetS prevalence in a large population-based study. Read More

    Development and psychometric testing of a theory-based tool to measure self-care in diabetes patients: the Self-Care of Diabetes Inventory.
    BMC Endocr Disord 2017 Oct 16;17(1):66. Epub 2017 Oct 16.
    University of Pennsylvania, Philadelphia, PA, USA.
    Background: Self-care is essential for patients with diabetes mellitus. Both clinicians and researchers must be able to assess the quality of that self-care. Available tools have various limitations and none are theoretically based. Read More

    Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients: a cross sectional study.
    BMC Endocr Disord 2017 Oct 13;17(1):64. Epub 2017 Oct 13.
    Department of Medical Physiology, College of Health Sciences, Jimma University, 378, Jimma, Ethiopia.
    Background: It is well known that dyslipidemia and chronic hyperglycemia increase the onset of diabetes and diabetic complication. The aim of this study is to see the association of trace metals elements and lipid profile among type 2 diabetes mellitus patients.

    Methods: The study was conducted on 214 type 2 diabetic patients at Jimma University Specialized Hospital, Jimma, Ethiopia. Read More

    Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis.
    BMC Endocr Disord 2017 Oct 10;17(1):63. Epub 2017 Oct 10.
    Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, 7925, South Africa.
    Insulin treatment has been associated with a paradoxical worsening of diabetes retinopathy since many years in European cohorts. Recently, this issue has been stressed by some studies conducted in other parts of the world. However, the mechanism underlying such evolution is not well understood. Read More

    Screening for celiac disease in poorly controlled type 2 diabetes mellitus: worth it or not?
    BMC Endocr Disord 2017 Oct 6;17(1):62. Epub 2017 Oct 6.
    Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, Ankara, Turkey.
    Background: Recent studies have demonstrated that immune factors might have a role in the pathophysiology of insulin resistance and type 2 diabetes mellitus (T2DM). Inappropriate glycemic control in patients with T2DM is an important risk factor for the occurrence of diabetes complications. The prevalence of celiac disease (CD) is high in type 1 diabetes mellitus however, there are scarce data about its prevalence in T2DM. Read More

    Hypertension outcomes of adrenalectomy in patients with primary aldosteronism: a systematic review and meta-analysis.
    BMC Endocr Disord 2017 Oct 3;17(1):61. Epub 2017 Oct 3.
    Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, China.
    Background: The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies.

    Methods: We conducted an observational meta-analysis to summarize the pooled hypertension cure rate of unilateral adrenalectomy in PA patients. Comprehensive electronic searches of PubMed, Embase, Cochrane, China National Knowledge Internet (CNKI), WanFang, SinoMed and Chongqing VIP databases were performed from initial state to May 20, 2016. Read More

    The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance.
    BMC Endocr Disord 2017 Sep 25;17(1):60. Epub 2017 Sep 25.
    Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.
    Background: Recent studies show that bile acids are involved in glucose and energy homeostasis through activation of G protein coupled membrane receptor (TGR5) and farnesoid X receptor (FXR). A few researches have explored changes of TGR5 and FXR in animals with impaired glucose regulation. This study aimed to observe changes of plasma total bile acids (TBA), glucagon-like-peptide 1 (GLP-1), fibroblast growth factor 15 (FGF15), intestinal expressions of TGR5 and FXR, and correlations between them in rats with glucose intolerance. Read More

    Prepubertal onset of slipped capital femoral epiphysis associated with hypothyroidism: a case report and literature review.
    BMC Endocr Disord 2017 Sep 18;17(1):59. Epub 2017 Sep 18.
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
    Background: Slipped capital femoral epiphysis (SCFE) is a common hip disorder characterized by displacement of the capital femoral epiphysis from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs during puberty, with obesity a common risk factor. We experienced a rare case of SCFE associated with hypothyroidism in a prepubescent patient who was not obese. Read More

    Clinical characteristics of adrenal crisis in adult population with and without predisposing chronic adrenal insufficiency: a retrospective cohort study.
    BMC Endocr Disord 2017 Sep 11;17(1):58. Epub 2017 Sep 11.
    Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
    Background: Adrenal crisis (AC) occurs in various clinical conditions but previous epidemiological studies in AC are limited to chronic adrenal insufficiency (AI) and sepsis. The aim of this study was to investigate characteristics of AC patients, including predisposing diseases and to describe candidate risk factors for AC such as comorbidities and glucocorticoid (GC) therapy.

    Methods: We conducted a retrospective cohort study using a claims database on 7. Read More

    Primary hyperparathyroidism caused by enormous unilateral water-clear cell parathyroid hyperplasia.
    BMC Endocr Disord 2017 Sep 9;17(1):57. Epub 2017 Sep 9.
    Second Department of Propedeutic Surgery, National and Kapodistrian University of Athens, Medical School, Laiko General Hospital, Athens, Greece.
    Background: Parathyroid water-clear cell hyperplasia (WCCH) and water-clear cell adenoma (WCCA) are rare causes of primary hyperparathyroidism. The frequency of WCCH seems to be less than 1% of all primary hyperplasia.

    Case Presentation: We report a 53-year-old woman with a large unilateral water clear cell parathyroid hyperplasia associated with primary hyperparathyroidism and severe osteoporosis. Read More

    Awareness and practices regarding eye diseases among patients with diabetes: a cross sectional analysis of the CoDiab-VD cohort.
    BMC Endocr Disord 2017 Sep 7;17(1):56. Epub 2017 Sep 7.
    Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
    Background: The increasing prevalence of diabetes is leading to a rise of eye diseases, augmenting the risk of sight-threatening complications. The aim of this study was to evaluate prevalence, awareness and practices regarding eye diseases among patients with diabetes in the canton of Vaud, Switzerland.

    Methods: A cohort of 323 patients with diabetes completed a self-administered questionnaire assessing prevalence, awareness and practices regarding eye diseases, besides health status and quality of care measures. Read More

    Prolonged preoperative treatment of acromegaly with Somatostatin analogs may improve surgical outcome in patients with invasive pituitary macroadenoma (Knosp grades 1-3): a retrospective cohort study conducted at a single center.
    BMC Endocr Disord 2017 Sep 6;17(1):55. Epub 2017 Sep 6.
    Key Laboratory of Endocrinology, Ministry of Health; Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.
    Background: This study aimed to investigate preoperative somatostatin analogs (SSAs) treatment on the surgical outcome in patients with acromegaly.

    Methods: An analysis of 358 patients with acromegaly was conducted. The preoperative medical therapy group (81 patients) received SSA treatment for at least 3 months prior to surgery, while the primary surgery group (277 patients) underwent transsphenoidal surgery directly. Read More

    Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
    BMC Endocr Disord 2017 Sep 2;17(1):54. Epub 2017 Sep 2.
    Department of Diabetes, Endocrinology and Metabolism, Chiba University Hospital, Chiba, 260-8670, Japan.
    Background: A functional pituitary adenoma can produce multiple anterior-pituitary hormones, such as growth hormone (GH) -producing adenomas (GHoma) with prolactin or thyrotropin stimulating hormone production in the same lineage. However, it is very rare that acromegaly shows subclinical Cushing's disease (SCD) beyond the lineage. Here we describe the involvement of intratumoral coexistence with 2 types of hormone-producing cells associated with different lineage in acromegaly concomitant with SCD. Read More

    Insulin treatment corrects hepcidin but not YKL-40 levels in persons with type 2 diabetes mellitus matched by body mass index, waist-to-height ratio, C-reactive protein and Creatinine.
    BMC Endocr Disord 2017 Aug 25;17(1):53. Epub 2017 Aug 25.
    Faculty of Medicine, University of Prishtina, Martyr's Boulevard n.n, 10000, Prishtina, Kosovo.
    Background: It has been shown that hepcidin and YKL-40 levels change in persons with insulin resistance in different circumstances. However, variations of the levels of these parameters through the stages of prediabetes and type 2 diabetes mellitus are unclear. We hypothesized that hepcidin levels will decrease in persons with prediabetes, while these levels will tend to correct when persons with diabetes are treated with insulin. Read More

    Participation of adults with disorders/differences of sex development (DSD) in the clinical study dsd-LIFE: design, methodology, recruitment, data quality and study population.
    BMC Endocr Disord 2017 Aug 18;17(1):52. Epub 2017 Aug 18.
    Klinik für Pädiatrie m.S. Pädiatrische Endokrinologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
    Background: dsd-LIFE is a comprehensive cross-sectional clinical outcome study of individuals with disorders/differences of sex development (DSD). This study focuses on various rare genetic conditions characterized by impaired gonadal or adrenal functionality.

    Methods/design: The study aims to assess quality of life (QoL) as a measure of psychosocial adaptation, psychosexual and mental health aspects as major outcomes. Read More

    Variations in diabetes remission rates after bariatric surgery in Spanish adults according to the use of different diagnostic criteria for diabetes.
    BMC Endocr Disord 2017 Aug 15;17(1):51. Epub 2017 Aug 15.
    UGC Endocrinología y Nutrición, Hospital Reina Sofía, Avenida Menéndez Pidal, s/n, 14004, Córdoba, Spain.
    Background: There are multiple criteria to define remission of type 2 diabetes (DM2) after bariatric surgery but there is not a specific one widely accepted. Our objectives were to compare diagnostic criteria for DM2 remission after bariatric surgery: Criteria from Spanish scientific associations (SEEN/SEEDO/SED) and from the American Diabetes Association (ADA). We also aim to analyse the degree of correlation between these sets of criteria. Read More

    The role of bariatric surgery to treat diabetes: current challenges and perspectives.
    BMC Endocr Disord 2017 Aug 10;17(1):50. Epub 2017 Aug 10.
    First Department of Propaedeutic Internal Medicine, Diabetes Centre, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
    Bariatric surgery is emerging as a powerful weapon against severe obesity and type 2 diabetes mellitus (T2DM). Given its role in metabolic regulation, the gastrointestinal tract constitutes a meaningful target to treat T2DM, especially in light of accumulating evidence that surgery with gastrointestinal manipulations may result in T2DM remission (metabolic surgery). The major mechanisms mediating the weight loss-independent effects of bariatric surgery comprise effects on tissue-specific insulin sensitivity, β-cell function and incretin responses, changes in bile acid composition and flow, modifications of gut microbiota, intestinal glucose metabolism and increased brown adipose tissue metabolic activity. Read More

    Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center.
    BMC Endocr Disord 2017 Aug 4;17(1):49. Epub 2017 Aug 4.
    Pituitary Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.
    Background: Acromegaly is a rare, slowly progressive disorder resulting from excessive growth hormone (GH) production by a pituitary somatotroph tumor. The objective of this study was to examine acromegaly treatment outcomes during long-term care at a specialized pituitary center in patients presenting with lack of biochemical control.

    Methods: Data came from an acromegaly registry at the Cedars-Sinai Medical Center Pituitary Center (center). Read More

    Renal injury is accelerated by global hypoxia-inducible factor 1 alpha deficiency in a mouse model of STZ-induced diabetes.
    BMC Endocr Disord 2017 Aug 3;17(1):48. Epub 2017 Aug 3.
    Laboratory of Molecular Pathogenetics, Institute of Biotechnology CAS, BIOCEV, Center of Excellence, Prumyslova 595, Vestec, 25242, Czechia.
    Background: Hypoxia inducible factor 1 (HIF-1) activates protective pathways to counteract hypoxia and prevent tissue damage in conjunction with renal injury. The aim of this study was to evaluate a role of HIF-1 in diabetes-induced kidney damage.

    Methods: We used a streptozotocin-induced diabetes mouse model and compared biochemical, histological and molecular parameters associated with kidney damage in Hif1α deficient (Hif1α (+/-) ) and wild-type mice. Read More

    Exploration of knowledge and understanding in patients with primary adrenal insufficiency: a mixed methods study.
    BMC Endocr Disord 2017 Aug 1;17(1):47. Epub 2017 Aug 1.
    School of Nursing, Institute of Clinical Sciences, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK.
    Background: Primary adrenal insufficiency (PAI) is a rare and severe condition requiring lifelong steroid replacement. During acute illness or stressful events, it is important to appropriately adjust glucocorticoid dose; failure to do so may lead to an adrenal crisis. The aim of the study was to explore patients PAI knowledge and understanding of the condition, steroid replacement adjustment during acute illness or stress and provided education. Read More

    A comparative effectiveness study of two culturally competent models of diabetes self-management programming for Latinos from low-income households.
    BMC Endocr Disord 2017 Jul 24;17(1):46. Epub 2017 Jul 24.
    University of New Mexico Health Sciences Center, Albuquerque, USA.
    Background: Diabetes risk is extremely high for Latinos from low-income households. Health guidelines recommend that individuals learn strategies to self-manage their diabetes, but getting people to adopt required lifestyle changes is challenging and many people are not able to prevent their pre-diabetes from escalating or effectively control their diabetes. Systematic reviews show that culturally competent self-management programs can significantly improve diabetes outcomes and different models for culturally competent programming have been developed. Read More

    Case report: rare skeletal manifestations in a child with primary hyperparathyroidism.
    BMC Endocr Disord 2017 Jul 21;17(1):45. Epub 2017 Jul 21.
    Orthopaedic Unit, National Hospital Sri Lanka, Colombo, Sri Lanka.
    Background: Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage due to routine blood investigations. Etiology of PHPT can be due to adenoma, hyperplasia or rarely carcinoma. Read More

    Elevated C-reactive protein, interleukin 6, tumor necrosis factor alpha and glycemic load associated with type 2 diabetes mellitus in rural Thais: a cross-sectional study.
    BMC Endocr Disord 2017 Jul 17;17(1):44. Epub 2017 Jul 17.
    Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Rd, Bangkok, 10400, Thailand.
    Background: The elevated levels of inflammatory markers, including C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL6) are supposed to be associated with type 2 diabetes mellitus (T2DM). Frequent high glycemic load (GL) consumption, central obesity, and a lack of physical activity are considered to be T2DM risk factors. This study aimed to determine the difference of these inflammatory markers as well as GL in individuals with versus those without T2DM in rural Thais. Read More

    Erratum to: Metabolic syndrome and its predictors in an urban population in Kenya: a cross sectional study.
    BMC Endocr Disord 2017 Jul 14;17(1):43. Epub 2017 Jul 14.
    Division of Chemical Pathology, Department of Pathology, Stellenbosch University, Tygerberg Hospital, P.O. Box 19113, Cape Town, South Africa.

    Metabolic characteristics of individuals at a high risk of type 2 diabetes - a comparative cross-sectional study.
    BMC Endocr Disord 2017 Jul 14;17(1):40. Epub 2017 Jul 14.
    The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, 413 45, Gothenburg, Sweden.
    Background: Type 2 diabetes (T2D) is associated with substantial morbidity and mortality. Individuals with a family history of T2D are at an increased risk of developing the disease. The aim of this study was to assess metabolic differences between first-degree relatives (FDR) of T2D patients and persons with no known family history of T2D (non-FDR). Read More

    Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine neoplasms in a Chinese population: a large, retrospective single-centre study.
    BMC Endocr Disord 2017 Jul 13;17(1):39. Epub 2017 Jul 13.
    Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, No.1, East Jianshe Road, Zhengzhou, 450052, China.
    Background: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common type of neuroendocrine tumors, accounting for more than half of neuroendocrine neoplasms (NENs). We performed a retrospective study in our center to investigate the clinicopathological features, risk factors of metastasis, and prognosis of GEP-NENs in a Chinese population.

    Methods: Four hundred forty patients with GEP-NENs treated at the First Affiliated Hospital of Zhengzhou University between January 2011 and March 2016 were analyzed retrospectively. Read More

    Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss.
    BMC Endocr Disord 2017 Jul 14;17(1):41. Epub 2017 Jul 14.
    Department of Diabetes and Endocrinology, University of Hull, Hull, UK.
    Background: Evidence suggests that endocannabinoid system activation through the cannabinoid receptor 1 (CB1) is associated with enhanced liver injury, and CB1 antagonism may be beneficial. The aim of this study was to determine the impact of rimonabant (CB1 antagonist) on alanine aminotransferase (ALT), a hepatocellular injury marker, and a hepatic inflammatory cytokine profile.

    Methods: Post hoc review of 2 studies involving 50 obese women with PCOS and well matched for weight, randomised to weight reducing therapy; rimonabant (20 mg od) or orlistat (120 mg tds), or to insulin sensitising therapy metformin, (500 mg tds), or pioglitazone (45 mg od). Read More

    Health-related quality of life in type-2 diabetes patients: a cross-sectional study in East China.
    BMC Endocr Disord 2017 Jul 6;17(1):38. Epub 2017 Jul 6.
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
    Background: Used the EuroQoL-5 dimension (EQ-5D) to evaluate the health status of 5310 residents who live in East China, and compared the health-related quality of life (HRQoL) with 311 patients with type 2 diabetes as well as to explore the main influence factors to HRQoL in East China.

    Methods: The cohort includes 5310 participants aged 18-89 years old lived in East China. EuroQoL-5 dimension (EQ-5D) scale was used for the assessment of health-related quality of life. Read More

    Metabolic syndrome and its predictors in an urban population in Kenya: A cross sectional study.
    BMC Endocr Disord 2017 Jul 4;17(1):37. Epub 2017 Jul 4.
    Division of Chemical Pathology, Department of Pathology, Stellenbosch University, P.O. Box 19113, Tygerberg Hospital, Cape Town, South Africa.
    Background: The metabolic syndrome (MetS) is a clustering of interrelated risk factors which doubles the risk of cardio-vascular disease (CVD) in 5-10 years and increases the risk of type 2 diabetes 5 fold. The identification of modifiable CVD risk factors and predictors of MetS in an otherwise healthy population is necessary in order to identify individuals who may benefit from early interventions. We sought to determine the prevalence of MetS as defined by the harmonized criteria and its predictors in subjectively healthy black Africans from various urban centres in Kenya. Read More

    Factors associated with diabetes-related distress over time among patients with T2DM in a tertiary hospital in Singapore.
    BMC Endocr Disord 2017 Jun 23;17(1):36. Epub 2017 Jun 23.
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
    Background: Persistent diabetes-related distress (DRD) is experienced by patients with Type 2 Diabetes Mellitus. Knowing factors associated with persistent DRD will aid clinicians in prioritising interventions efforts.

    Methods: A total of 216 patients were recruited from a tertiary hospital in Singapore, an Asian city state, and followed for 1. Read More

    Acute airway compromise due to parathyroid tumour apoplexy: an exceptionally rare and potentially life-threatening presentation.
    BMC Endocr Disord 2017 Jun 21;17(1):35. Epub 2017 Jun 21.
    Department of Endocrinology, Beaumont Hospital, Dublin, Ireland.
    Background: Spontaneous haemorrhage into a parathyroid adenoma is a rare and potentially life-threatening presentation.

    Case Presentation: We report the case of a 45 year old female recently diagnosed with primary hyperparathyroidism who presented with chest discomfort and acute airway compromise due to spontaneous extracapsular haemorrhage into a parathyroid adenoma. Computed tomography (CT) imaging showed a hypopharyngeal haematoma extending 10 cm into the superior mediastinum. Read More

    Use of social adaptability index to explain self-care and diabetes outcomes.
    BMC Endocr Disord 2017 Jun 20;17(1):34. Epub 2017 Jun 20.
    Center for Patient Care and Outcomes Research (PCOR), Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
    Background: To examine whether the social adaptability index (SAI) alone or components of the index provide a better explanatory model for self-care and diabetes outcomes.

    Methods: Six hundred fifteen patients were recruited from two primary care settings. A series of multiple linear regression models were run to assess (1) associations between the SAI and diabetes self-care/outcomes, and (2) associations between individual SAI indicator variables and diabetes self-care/outcomes. Read More

    Communication with young people in paediatric and adult endocrine consultations: an intervention development and feasibility study.
    BMC Endocr Disord 2017 Jun 15;17(1):33. Epub 2017 Jun 15.
    School of Health Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
    Background: Communication is complex in endocrine care, particularly during transition from paediatric to adult services. The aims of this study were to examine the feasibility of interventions to support young people to interact with clinicians.

    Methods: Development and evaluation of a complex intervention in 2 phases: Pre-intervention observational study; Intervention feasibility study. Read More

    Quality measure and weight loss assessment in patients with type 2 diabetes mellitus treated with canagliflozin or dipeptidyl peptidase-4 inhibitors.
    BMC Endocr Disord 2017 Jun 8;17(1):32. Epub 2017 Jun 8.
    Analysis Group, Inc., Boston, MA, USA.
    Background: Achieving control of glycated hemoglobin (HbA1c), blood pressure (BP), and body weight (BW) remains a challenge for most patients with type 2 diabetes mellitus (T2DM). In clinical trials, canagliflozin (CANA), an inhibitor of sodium-glucose co-transporter 2, has shown significant improvement compared to some dipeptidyl peptidase-4 (DPP-4) inhibitors in the achievement of such quality measures. This study used recent electronic medical records (EMR) data to assess quality measure achievement of HbA1C, BP, and BW loss in patients treated with CANA versus DPP-4 inhibitors. Read More

    Trends in sex differences in the receipt of quality of care indicators among adults with diabetes: United States 2002-2011.
    BMC Endocr Disord 2017 Jun 6;17(1):31. Epub 2017 Jun 6.
    Department of Medicine, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Clinical Cancer Center Building Suite C5400, Milwaukee, WI 53226, USA.
    Background: Evidence suggests disparities in quality of care (QoC) indicators based on sex exist in adults diagnosed with diabetes; however, this research is limited. Therefore, the objective of this research study was to assess differences in QOC indicators in a nationally representative sample of men and women with diabetes.

    Methods: Cross-sectional study of 17,702 men and women (≥18 years of age) with diabetes from the 2002-2011 Medical Expenditure Panel Survey Household Component. Read More

    Patterns, control and complications of diabetes from a hospital based registry established in a low income country.
    BMC Endocr Disord 2017 Jun 5;17(1):30. Epub 2017 Jun 5.
    Section of Endocrinology, Department of Medicine, Aga Khan University, Karachi, Pakistan.
    Background: Diabetes registry enables practitioners to measure the characteristics and patterns of diabetes across their patient population. They also provide insight into practice patterns which can be very effective in improving care and preventing complications. The aim of this study was to assess the patterns, control levels and complications at the baseline of the patients attending clinic at the large tertiary care hospital in Karachi, Pakistan with the help of the registry. Read More

    Factors associated with impaired color vision without retinopathy amongst people with type 2 diabetes mellitus: a cross-sectional study.
    BMC Endocr Disord 2017 Jun 2;17(1):29. Epub 2017 Jun 2.
    SingHealth Polyclinics, 167, Jalan Bukit Merah, Tower 5, #15-10, 150167, Singapore, Singapore.
    Background: Patients with type 2 diabetes mellitus (T2DM) may develop color vision impairment. This study aimed to determine the prevalence and factors associated with impaired color vision in patients with T2DM but without diabetic retinopathy.

    Methods: Enrolment criteria included multi-ethnic Asian participants, age 21 to 80 years, with known T2DM for a minimum of 2 years. Read More

    Association of calf circumference with insulin resistance and non-alcohol fatty liver disease: the REACTION study.
    BMC Endocr Disord 2017 May 30;17(1):28. Epub 2017 May 30.
    Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
    Background: The feature of nonalcoholic fatty liver disease (NAFLD) is pathological excessive liver lipid accumulation of subjects who without history of alcohol abuse. Calf circumference is a proxy for lower-body fat and screening method for the identification of subjects with acatastatic lipid accumulation. The objective of this study was to examine the association between calf circumference and NAFLD. Read More

    Pulse wave velocity and cardiac autonomic function in type 2 diabetes mellitus.
    BMC Endocr Disord 2017 May 19;17(1):27. Epub 2017 May 19.
    First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 17 Agiou Thoma St, 11527, Athens, Greece.
    Background: Increased carotid-femoral pulse wave velocity (PWV) has been associated with incident cardiovascular disease, independently of traditional risk factors. Cardiac autonomic dysfunction is a common complication of diabetes and has been associated with reduced aortic distensibility. However, the association of cardiac autonomic dysfunction with PWV is not known. Read More

    Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome.
    BMC Endocr Disord 2017 May 19;17(1):26. Epub 2017 May 19.
    Weill Cornell Medicine Qatar, PO Box 24144, Doha, Qatar.
    Background: Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ovary syndrome (PCOS) may differ, this study compared the different androgen parameters in non-obese compared to obese women with PCOS, and in normal subjects.

    Methods: Eleven non-obese and 14 obese women with PCOS were recruited and compared to 11 control women without PCOS. Read More

    Age differences in diabetes-related complications and glycemic control.
    BMC Endocr Disord 2017 May 4;17(1):25. Epub 2017 May 4.
    Khalkhal Health Center, School of Khalkhal Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran.
    Background: This study aimed to examine the associations of age with the presence of complications and glycemic control in the Northwest of Iran.

    Methods: A total of 649 people with diabetes who were >25 years old and had a caring record in diabetes clinics in two Northwestern provinces of Iran during 2014-15, were recruited in this cross-sectional study. General information including demographic, socioeconomic status and lifestyle factors were collected by trained interviewers. Read More

    Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study.
    BMC Endocr Disord 2017 Apr 7;17(1):24. Epub 2017 Apr 7.
    The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Austin Health, 245 Burgundy Street, Heidelberg, VIC, 3084, Australia.
    Background: Cognitive impairment is common in type 2 diabetes mellitus, and there is a strong association between type 2 diabetes and Alzheimer's disease. However, we do not know which type 2 diabetes patients will dement or which biomarkers predict cognitive decline. Left ventricular hypertrophy (LVH) is potentially such a marker. Read More

    The effectiveness of a value-based EMOtion-cognition-Focused educatIonal programme to reduce diabetes-related distress in Malay adults with Type 2 diabetes (VEMOFIT): study protocol for a cluster randomised controlled trial.
    BMC Endocr Disord 2017 Apr 4;17(1):22. Epub 2017 Apr 4.
    Department of General Practice, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispost Str.6.131, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.
    Background: Type 2 diabetes mellitus (T2DM) patients experience many psychosocial problems related to their diabetes. These often lead to emotional disorders such as distress, stress, anxiety and depression, resulting in decreased self-care, quality of life and disease control. The purpose of the current study is to evaluate the effectiveness of a brief value-based emotion-focused educational programme in adults with T2DM on diabetes-related distress (DRD), depressive symptoms, illness perceptions, quality of life, diabetes self-efficacy, self-care and clinical outcomes. Read More

    Assessment of platelets morphological changes and serum butyrylcholinesterase activity in children with diabetic ketoacidosis: a case control study.
    BMC Endocr Disord 2017 Apr 4;17(1):23. Epub 2017 Apr 4.
    Department of Pediatrics, Faculty of Medicine, Minia University, El-Minya, Egypt.
    Background: Many studies indicated that mean platelet volume (MPV) and platelet distribution width (PDW) may be valuable in the diagnosis and management of clinical disorders; also, serum butyrylcholinesterase activity (BChE) was suggested to be linked to systemic inflammation and oxidative stress. Limited studies measured these readily available markers in children with diabetic ketoacidosis (DKA). Our objectives were to measure MPV, PDW and BChE in children with DKA; and to assess if any of these markers reflects the severity of DKA. Read More


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