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    550 results match your criteria BMC Endocrine Disorders[Journal]

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    Design of the Growth hormone deficiency and Efficacy of Treatment (GET) score and non-interventional proof of concept study.
    BMC Endocr Disord 2018 Feb 13;18(1):10. Epub 2018 Feb 13.
    Clinical, Medical & Regulatory Department, Novo Nordisk Pharma GmbH, 55127, Mainz, Germany.
    Background: The adverse effects of growth hormone (GH) deficiency (GHD) in adults (AGHD) on metabolism and health-related quality of life (HRQoL) can be improved with GH substitution. This investigation aimed to design a score summarising the features of GHD and evaluate its ability to measure the effect of GH substitution in AGHD.

    Methods: The Growth hormone deficiency and Efficacy of Treatment (GET) score (0-100 points) assessed (weighting): HRQoL (40%), disease-related days off work (10%), bone mineral density (20%), waist circumference (10%), low-density lipoprotein cholesterol (10%) and body fat mass (10%). Read More

    An international survey on hypoglycemia among insulin-treated type I and type II diabetes patients: Turkey cohort of the non-interventional IO HAT study.
    BMC Endocr Disord 2018 Feb 13;18(1). Epub 2018 Feb 13.
    Division of Endocrinology and Metabolism, School of Medicine, Baskent University, Ankara, Turkey.
    Background: Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from Turkey cohort are presented here. Read More

    FSH may be a useful tool to allow early diagnosis of Turner syndrome.
    BMC Endocr Disord 2018 Feb 7;18(1). Epub 2018 Feb 7.
    Department of Medical Genetics, FCM, Unicamp, Rua Tessalia Vieira de Camargo, 126, Campinas, SP, 13083-887, Brazil.
    Background: Ultrasensitive assays to measure pre-pubertal gonadotropins levels could help identify patients with Turner syndrome (TS) in mid-childhood, but studies in this field are scarce. The aim of this study was to analyze gonadotropins levels in girls with TS throughout childhood.

    Methods: Retrospective longitudinal study conducted with 15 girls with TS diagnosed with < 5 years whose FSH and LH measures were available since then. Read More

    Orbital radiotherapy plus three-wall orbital decompression in a patient with rare ocular manifestations of thyroid eye disease: case report.
    BMC Endocr Disord 2018 Feb 6;18(1). Epub 2018 Feb 6.
    Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 ZhiZaoJu Road, Shanghai, 200011, China.
    Background: Thyroid eye disease (TED) is a debilitating autoimmune orbital disease that is often a result of Graves' disease. Dysthyroid optic neuropathy (DON) is a rare but sight-threatening manifestation of TED with therapeutic challenges that can potentially lead to visual loss.

    Case Presentation: A 74-year-old man experienced active TED with extremely severe redness and swelling of the conjunctiva, loss of visual acuity and exacerbation of disfiguring proptosis. Read More

    Stem cells and beta cell replacement therapy: a prospective health technology assessment study.
    BMC Endocr Disord 2018 Jan 30;18(1). Epub 2018 Jan 30.
    Department of Emergency Medicine Research Group, Department of Emergency Medicine, University of Alberta, 8303 - 112 Street, Edmonton, AB, T6G 2T4, Canada.
    Background: Although current beta cell replacement therapy is effective in stabilizing glycemic control in highly selected patients with refractory type 1 diabetes, many hurdles are inherent to this and other donor-based transplantation methods. One solution could be moving to stem cell-derived transplant tissue. This study investigates a novel stem cell-derived graft and implant technology and explores the circumstances of its cost-effectiveness compared to intensive insulin therapy. Read More

    Sex-related illness perception and self-management of a Thai type 2 diabetes population: a cross-sectional descriptive design.
    BMC Endocr Disord 2018 Jan 30;18(1). Epub 2018 Jan 30.
    Faculty of Health and Society, Malmö University, SE 205 06, Malmö, Sweden.
    Background: Increased knowledge concerning the differences in the illness perception and self-management among sexes is needed for planning proper support programs for patients with diabetes. The aim of this study was to investigate the illness perception and self-management among Thai women and Thai men with type 2 diabetes and to investigate the psychometric properties of the translated instruments used.

    Methods: In a suburban province of Thailand, 220 women and men with type 2 diabetes participated in a cross-sectional descriptive study. Read More

    The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report.
    BMC Endocr Disord 2018 Jan 30;18(1). Epub 2018 Jan 30.
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Chuo-Ward, Honjo, Kumamoto, 860-8556, Japan.
    Background: Gestational diabetes insipidus (GDI) is a rare endocrine complication during pregnancy that is associated with vasopressinase overproduction from the placenta. Although increased vasopressinase is associated with placental volume, the regulation of placental growth in the later stage of pregnancy is not well known.

    Case Presentation: A 16-year-old pregnant woman was urgently transferred to our hospital because of threatened premature labor when the Kumamoto earthquakes hit the area where she lived. Read More

    Association of thyroid nodules with adiposity: a community-based cross-sectional study in China.
    BMC Endocr Disord 2018 Jan 27;18(1). Epub 2018 Jan 27.
    Endocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 8 Huadian East Road, Nanjing, 210028, China.
    Background: The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether thyroid nodules are associated with overweight and obesity, as defined with body mass index (BMI) and waist circumference.

    Methods: The study included 1482 subjects (≥20 years of age; residing in Nanjing, China) receiving questionnaire interview, anthropometric measurements, laboratory tests and thyroid ultrasonography in 2009-2010. Read More

    Efficacy of combined treatment with pasireotide, pegvisomant and cabergoline in an acromegalic patient resistant to other treatments: a case report.
    BMC Endocr Disord 2018 Jan 24;18(1). Epub 2018 Jan 24.
    Section of Endocrinology, Diabetology and Metabolic Diseases, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy.
    Background: The approach to acromegalic patients with persistent acromegaly after surgery and inadequate response to first-generation somatostatin receptor ligands (SRLs) should be strictly tailored. Current options include new pituitary surgery and/or radiosurgery, or alternative medical treatment with SRLs high dose regimens, pegvisomant (PEG) as monotherapy, or combined therapy with the addition of PEG or cabergoline to SRLs. A new pharmacological approach includes pasireotide, a second-generation SRL approved for patients who do not adequately respond to surgery and/or for whom surgery is not an option. Read More

    The effects of metformin in type 1 diabetes mellitus.
    BMC Endocr Disord 2018 Jan 16;18(1). Epub 2018 Jan 16.
    Department of Endocrinology and Metabolism, Ankara Diskapi Teaching and Research Hospital, Ankara, Turkey.
    Background: This retrospective study investigated the effect of adding metformin to pharmacologic insulin dosing in type 1 diabetics on insulin therapy 1 year after treatment compared with patients on insulin therapy alone.

    Methods: Twenty-nine adults with type 1 diabetes who had metformin added to their insulin therapy for 12 months were compared with 29 adults with type 1 diabetes who remained on insulin-alone therapy.

    Results: Fifty-eight patients with C peptide negative-type 1 diabetics (26 females, mean age: 29. Read More

    Impact of a structured multicomponent educational intervention program on metabolic control of patients with type 2 diabetes.
    BMC Endocr Disord 2017 Dec 15;17(1):77. Epub 2017 Dec 15.
    University of Coimbra, Psychology and Sciences of Education Faculty, Santarém, Portugal.
    Background: Diabetes is one of the most common metabolic disorders, with a high prevalence of patients with poor metabolic control. Worldwide, evidence highlights the importance of developing and implementing educational interventions that can reduce this burden. The main objective of this study was to analyse the impact of a lifestyle centred intervention on glycaemic control of poorly controlled type 2 diabetic patients, followed in a Community Care Centre. Read More

    Hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients at Hawassa university comprehensive specialized hospital, South West Ethiopia.
    BMC Endocr Disord 2017 Dec 12;17(1):76. Epub 2017 Dec 12.
    Hawasa University, Hawassa, Ethiopia.
    Background: Metabolic syndrome is a cluster of the most dangerous heart attack risk factors such as diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure. Hyperuricemia is a condition in which the serum uric acid concentration is greater than 5.5 mg per deciliter for child and greater than 7. Read More

    Socio-demographic determinants and effect of structured personal diabetes care: a 19-year follow-up of the randomized controlled study diabetes Care in General Practice (DCGP).
    BMC Endocr Disord 2017 Dec 8;17(1):75. Epub 2017 Dec 8.
    The Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
    Background: We investigated how four aspects of socio-demography influence the effectiveness of an intervention with structured personal diabetes care on long-term outcomes.

    Methods: The Diabetes Care in General Practice (DCGP) study is a cluster-randomized trial involving a population-based sample of 1381 patients with newly diagnosed type 2-diabetes mellitus. We investigated how education, employment, cohabitation status and residence influenced the effectiveness of 6 years of intervention with structured personal diabetes care, resembling present day recommendations. Read More

    Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism.
    BMC Endocr Disord 2017 Dec 6;17(1):74. Epub 2017 Dec 6.
    Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-sayama, Osaka, 589-8511, Japan.
    Background: We report a rare case of a juxta-adrenal schwannoma that could not be discriminated from an adrenal tumor before surgical resection and was complicated by bilateral hyperaldosteronism. To the best of our knowledge, this is first case in which both a juxta-adrenal schwannoma and hyperaldosteronism co-existed.

    Case Presentation: A 69-year-old male treated for hypertension was found to have a left supra-renal mass (5. Read More

    Adequacy of control of cardiovascular risk factors in ambulatory patients with type 2 diabetes attending diabetes out-patients clinic at a county hospital, Kenya.
    BMC Endocr Disord 2017 Dec 1;17(1):73. Epub 2017 Dec 1.
    Kenyatta National Hospital, Nairobi, Kenya.
    Background: Type 2 diabetes is associated with substantial cardiovascular morbidity and mortality arising from the high prevalence of cardiovascular risk factors such as hypertension, dyslipidaemia, obesity, poor glycaemic control and albuminuria. Adequacy of control of these risk factors determines the frequency and outcome of cardiovascular events in the patients. Current clinical practice guidelines emphasize primary prevention of cardiovascular disease in type 2 diabetes. Read More

    Low bone turnover in premenopausal women with type 2 diabetes mellitus as an early process of diabetes-associated bone alterations: a cross-sectional study.
    BMC Endocr Disord 2017 Nov 29;17(1):72. Epub 2017 Nov 29.
    Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
    Background: Individuals with Diabetes Mellitus (DM) are at increased risk for fracture due to the decrease in bone strength and quality. Serum procollagen type I intact N-terminal (P1NP) and serum C-terminal cross-linking telopeptide of type I collagen (CTX) as markers of bone formation and resorption, respectively, have been reported to be decreased in T2DM. It remains unclear whether diabetes-associated alterations in the bone turnover of T2DM individuals are related to the longer duration of the disease or may occur earlier. Read More

    Vitamin D, parathyroid hormone and metabolic syndrome - the PORMETS study.
    BMC Endocr Disord 2017 Nov 17;17(1):71. Epub 2017 Nov 17.
    Grupo de Estudo da Insulino-Resistência, Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo, Lisboa, Portugal.
    Background: Vitamin D (VitD) and parathyroid hormone (PTH) play important roles in calcium metabolism and skeletal homeostasis. Estimates of the VitD status in several European countries show large variations between them. In addition, no national population-based estimate has been published. Read More

    In-patient Tolvaptan use in SIADH: care audit, therapy observation and outcome analysis.
    BMC Endocr Disord 2017 Nov 6;17(1):69. Epub 2017 Nov 6.
    Department of Endocrinology & Diabetes, Queen Alexandra Hospital Portsmouth, Portsmouth, PO6 3LY, UK.
    Background: Indications for use of tolvaptan in SIADH-associated hyponatraemia remain controversial. We audited our local guidelines for Tolvaptan use in this situation to review treatment implications including drug safety, hospital admission episode analysis (episodes of liver toxicity, CNS myelinolysis, sodium-related re-admission rates), morbidity; mortality and underlying aetiologies.

    Methods: We report a retrospective case series analysis of on-going treatment outcomes (case-note review) for 31 patients (age 73. Read More

    A randomized, placebo-controlled clinical trial evaluating the safety and efficacy of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus inadequately controlled by glimepiride and metformin.
    BMC Endocr Disord 2017 Nov 6;17(1):70. Epub 2017 Nov 6.
    Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA.
    Background: Type 2 diabetes (T2D) is a progressive disease that often requires a patient to use multiple antihyperglycemic agents to achieve glycemic control with disease progression. Omarigliptin is a once-weekly dipeptidyl peptidase-4 inhibitor. The purpose of this trial was to assess the efficacy and safety of adding omarigliptin to the treatment regimen of patients with T2D inadequately controlled by dual therapy with metformin and glimepiride. Read More

    Serum vaspin concentration in elderly patients with type 2 diabetes mellitus and macrovascular complications.
    BMC Endocr Disord 2017 Oct 24;17(1):67. Epub 2017 Oct 24.
    Department of Cardiology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
    Background: Adipose tissue, an endocrine organ of the body, is involved in some obesity-related disease states such as insulin resistance, diabetes mellitus, and atherosclerosis. Vaspin is a novel adipocyte with insulin sensitizing effects. In this study, we planned to estimate serum vaspin concentrations as related to glycemic status and the presence of macrovascular complications among elderly patients with type-2 diabetes mellitus (T2DM). Read More

    Effectiveness and safety of exenatide in Korean patients with type 2 diabetes inadequately controlled with oral hypoglycemic agents: an observational study in a real clinical practice.
    BMC Endocr Disord 2017 Oct 25;17(1):68. Epub 2017 Oct 25.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-Ro, Seoul, Seodaemun-Gu, 03722, South Korea.
    Background: Randomized clinical trials have shown the efficacy and safety of short-acting exenatide in patients with type 2 diabetes mellitus (T2DM). The aim of this observational study was to investigate the effectiveness and safety of exenatide twice a day in Korean patients with T2DM who are suboptimally controlled with oral hypoglycemic agents.

    Methods: This study was a post hoc analysis of multi-center (71 centers), prospective, observational, single-arm, post-marketing study of short-acting exenatide 5 to 10 μg twice a day from March 2008 to March 2014 and analyzed those who finished the follow-up over 20 weeks of medication. Read More

    Thyroid function and metabolic syndrome in the population-based LifeLines cohort study.
    BMC Endocr Disord 2017 Oct 16;17(1):65. Epub 2017 Oct 16.
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, HPC AA31, P.O. Box 30001, 9700 RB, Groningen, The Netherlands.
    Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors which includes abdominal obesity, dyslipidaemia, elevated blood pressure and impaired fasting glucose. Earlier studies have reported a relationship between thyroid function and some MetS components or suggested that serum free thyroxine (FT4) or free triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to MetS prevalence in a large population-based study. Read More

    Development and psychometric testing of a theory-based tool to measure self-care in diabetes patients: the Self-Care of Diabetes Inventory.
    BMC Endocr Disord 2017 Oct 16;17(1):66. Epub 2017 Oct 16.
    University of Pennsylvania, Philadelphia, PA, USA.
    Background: Self-care is essential for patients with diabetes mellitus. Both clinicians and researchers must be able to assess the quality of that self-care. Available tools have various limitations and none are theoretically based. Read More

    Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients: a cross sectional study.
    BMC Endocr Disord 2017 Oct 13;17(1):64. Epub 2017 Oct 13.
    Department of Medical Physiology, College of Health Sciences, Jimma University, 378, Jimma, Ethiopia.
    Background: It is well known that dyslipidemia and chronic hyperglycemia increase the onset of diabetes and diabetic complication. The aim of this study is to see the association of trace metals elements and lipid profile among type 2 diabetes mellitus patients.

    Methods: The study was conducted on 214 type 2 diabetic patients at Jimma University Specialized Hospital, Jimma, Ethiopia. Read More

    Mechanism of worsening diabetic retinopathy with rapid lowering of blood glucose: the synergistic hypothesis.
    BMC Endocr Disord 2017 Oct 10;17(1):63. Epub 2017 Oct 10.
    Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, 7925, South Africa.
    Insulin treatment has been associated with a paradoxical worsening of diabetes retinopathy since many years in European cohorts. Recently, this issue has been stressed by some studies conducted in other parts of the world. However, the mechanism underlying such evolution is not well understood. Read More

    Screening for celiac disease in poorly controlled type 2 diabetes mellitus: worth it or not?
    BMC Endocr Disord 2017 Oct 6;17(1):62. Epub 2017 Oct 6.
    Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, Ankara, Turkey.
    Background: Recent studies have demonstrated that immune factors might have a role in the pathophysiology of insulin resistance and type 2 diabetes mellitus (T2DM). Inappropriate glycemic control in patients with T2DM is an important risk factor for the occurrence of diabetes complications. The prevalence of celiac disease (CD) is high in type 1 diabetes mellitus however, there are scarce data about its prevalence in T2DM. Read More

    Hypertension outcomes of adrenalectomy in patients with primary aldosteronism: a systematic review and meta-analysis.
    BMC Endocr Disord 2017 Oct 3;17(1):61. Epub 2017 Oct 3.
    Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, China.
    Background: The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies.

    Methods: We conducted an observational meta-analysis to summarize the pooled hypertension cure rate of unilateral adrenalectomy in PA patients. Comprehensive electronic searches of PubMed, Embase, Cochrane, China National Knowledge Internet (CNKI), WanFang, SinoMed and Chongqing VIP databases were performed from initial state to May 20, 2016. Read More

    The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance.
    BMC Endocr Disord 2017 Sep 25;17(1):60. Epub 2017 Sep 25.
    Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.
    Background: Recent studies show that bile acids are involved in glucose and energy homeostasis through activation of G protein coupled membrane receptor (TGR5) and farnesoid X receptor (FXR). A few researches have explored changes of TGR5 and FXR in animals with impaired glucose regulation. This study aimed to observe changes of plasma total bile acids (TBA), glucagon-like-peptide 1 (GLP-1), fibroblast growth factor 15 (FGF15), intestinal expressions of TGR5 and FXR, and correlations between them in rats with glucose intolerance. Read More

    Prepubertal onset of slipped capital femoral epiphysis associated with hypothyroidism: a case report and literature review.
    BMC Endocr Disord 2017 Sep 18;17(1):59. Epub 2017 Sep 18.
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
    Background: Slipped capital femoral epiphysis (SCFE) is a common hip disorder characterized by displacement of the capital femoral epiphysis from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs during puberty, with obesity a common risk factor. We experienced a rare case of SCFE associated with hypothyroidism in a prepubescent patient who was not obese. Read More

    Clinical characteristics of adrenal crisis in adult population with and without predisposing chronic adrenal insufficiency: a retrospective cohort study.
    BMC Endocr Disord 2017 Sep 11;17(1):58. Epub 2017 Sep 11.
    Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
    Background: Adrenal crisis (AC) occurs in various clinical conditions but previous epidemiological studies in AC are limited to chronic adrenal insufficiency (AI) and sepsis. The aim of this study was to investigate characteristics of AC patients, including predisposing diseases and to describe candidate risk factors for AC such as comorbidities and glucocorticoid (GC) therapy.

    Methods: We conducted a retrospective cohort study using a claims database on 7. Read More

    Primary hyperparathyroidism caused by enormous unilateral water-clear cell parathyroid hyperplasia.
    BMC Endocr Disord 2017 Sep 9;17(1):57. Epub 2017 Sep 9.
    Second Department of Propedeutic Surgery, National and Kapodistrian University of Athens, Medical School, Laiko General Hospital, Athens, Greece.
    Background: Parathyroid water-clear cell hyperplasia (WCCH) and water-clear cell adenoma (WCCA) are rare causes of primary hyperparathyroidism. The frequency of WCCH seems to be less than 1% of all primary hyperplasia.

    Case Presentation: We report a 53-year-old woman with a large unilateral water clear cell parathyroid hyperplasia associated with primary hyperparathyroidism and severe osteoporosis. Read More

    Awareness and practices regarding eye diseases among patients with diabetes: a cross sectional analysis of the CoDiab-VD cohort.
    BMC Endocr Disord 2017 Sep 7;17(1):56. Epub 2017 Sep 7.
    Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
    Background: The increasing prevalence of diabetes is leading to a rise of eye diseases, augmenting the risk of sight-threatening complications. The aim of this study was to evaluate prevalence, awareness and practices regarding eye diseases among patients with diabetes in the canton of Vaud, Switzerland.

    Methods: A cohort of 323 patients with diabetes completed a self-administered questionnaire assessing prevalence, awareness and practices regarding eye diseases, besides health status and quality of care measures. Read More

    Prolonged preoperative treatment of acromegaly with Somatostatin analogs may improve surgical outcome in patients with invasive pituitary macroadenoma (Knosp grades 1-3): a retrospective cohort study conducted at a single center.
    BMC Endocr Disord 2017 Sep 6;17(1):55. Epub 2017 Sep 6.
    Key Laboratory of Endocrinology, Ministry of Health; Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.
    Background: This study aimed to investigate preoperative somatostatin analogs (SSAs) treatment on the surgical outcome in patients with acromegaly.

    Methods: An analysis of 358 patients with acromegaly was conducted. The preoperative medical therapy group (81 patients) received SSA treatment for at least 3 months prior to surgery, while the primary surgery group (277 patients) underwent transsphenoidal surgery directly. Read More

    Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing's disease: a case report.
    BMC Endocr Disord 2017 Sep 2;17(1):54. Epub 2017 Sep 2.
    Department of Diabetes, Endocrinology and Metabolism, Chiba University Hospital, Chiba, 260-8670, Japan.
    Background: A functional pituitary adenoma can produce multiple anterior-pituitary hormones, such as growth hormone (GH) -producing adenomas (GHoma) with prolactin or thyrotropin stimulating hormone production in the same lineage. However, it is very rare that acromegaly shows subclinical Cushing's disease (SCD) beyond the lineage. Here we describe the involvement of intratumoral coexistence with 2 types of hormone-producing cells associated with different lineage in acromegaly concomitant with SCD. Read More

    Insulin treatment corrects hepcidin but not YKL-40 levels in persons with type 2 diabetes mellitus matched by body mass index, waist-to-height ratio, C-reactive protein and Creatinine.
    BMC Endocr Disord 2017 Aug 25;17(1):53. Epub 2017 Aug 25.
    Faculty of Medicine, University of Prishtina, Martyr's Boulevard n.n, 10000, Prishtina, Kosovo.
    Background: It has been shown that hepcidin and YKL-40 levels change in persons with insulin resistance in different circumstances. However, variations of the levels of these parameters through the stages of prediabetes and type 2 diabetes mellitus are unclear. We hypothesized that hepcidin levels will decrease in persons with prediabetes, while these levels will tend to correct when persons with diabetes are treated with insulin. Read More

    Participation of adults with disorders/differences of sex development (DSD) in the clinical study dsd-LIFE: design, methodology, recruitment, data quality and study population.
    BMC Endocr Disord 2017 Aug 18;17(1):52. Epub 2017 Aug 18.
    Klinik für Pädiatrie m.S. Pädiatrische Endokrinologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
    Background: dsd-LIFE is a comprehensive cross-sectional clinical outcome study of individuals with disorders/differences of sex development (DSD). This study focuses on various rare genetic conditions characterized by impaired gonadal or adrenal functionality.

    Methods/design: The study aims to assess quality of life (QoL) as a measure of psychosocial adaptation, psychosexual and mental health aspects as major outcomes. Read More

    Variations in diabetes remission rates after bariatric surgery in Spanish adults according to the use of different diagnostic criteria for diabetes.
    BMC Endocr Disord 2017 Aug 15;17(1):51. Epub 2017 Aug 15.
    UGC Endocrinología y Nutrición, Hospital Reina Sofía, Avenida Menéndez Pidal, s/n, 14004, Córdoba, Spain.
    Background: There are multiple criteria to define remission of type 2 diabetes (DM2) after bariatric surgery but there is not a specific one widely accepted. Our objectives were to compare diagnostic criteria for DM2 remission after bariatric surgery: Criteria from Spanish scientific associations (SEEN/SEEDO/SED) and from the American Diabetes Association (ADA). We also aim to analyse the degree of correlation between these sets of criteria. Read More

    The role of bariatric surgery to treat diabetes: current challenges and perspectives.
    BMC Endocr Disord 2017 Aug 10;17(1):50. Epub 2017 Aug 10.
    First Department of Propaedeutic Internal Medicine, Diabetes Centre, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
    Bariatric surgery is emerging as a powerful weapon against severe obesity and type 2 diabetes mellitus (T2DM). Given its role in metabolic regulation, the gastrointestinal tract constitutes a meaningful target to treat T2DM, especially in light of accumulating evidence that surgery with gastrointestinal manipulations may result in T2DM remission (metabolic surgery). The major mechanisms mediating the weight loss-independent effects of bariatric surgery comprise effects on tissue-specific insulin sensitivity, β-cell function and incretin responses, changes in bile acid composition and flow, modifications of gut microbiota, intestinal glucose metabolism and increased brown adipose tissue metabolic activity. Read More

    Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center.
    BMC Endocr Disord 2017 Aug 4;17(1):49. Epub 2017 Aug 4.
    Pituitary Center, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.
    Background: Acromegaly is a rare, slowly progressive disorder resulting from excessive growth hormone (GH) production by a pituitary somatotroph tumor. The objective of this study was to examine acromegaly treatment outcomes during long-term care at a specialized pituitary center in patients presenting with lack of biochemical control.

    Methods: Data came from an acromegaly registry at the Cedars-Sinai Medical Center Pituitary Center (center). Read More

    Renal injury is accelerated by global hypoxia-inducible factor 1 alpha deficiency in a mouse model of STZ-induced diabetes.
    BMC Endocr Disord 2017 Aug 3;17(1):48. Epub 2017 Aug 3.
    Laboratory of Molecular Pathogenetics, Institute of Biotechnology CAS, BIOCEV, Center of Excellence, Prumyslova 595, Vestec, 25242, Czechia.
    Background: Hypoxia inducible factor 1 (HIF-1) activates protective pathways to counteract hypoxia and prevent tissue damage in conjunction with renal injury. The aim of this study was to evaluate a role of HIF-1 in diabetes-induced kidney damage.

    Methods: We used a streptozotocin-induced diabetes mouse model and compared biochemical, histological and molecular parameters associated with kidney damage in Hif1α deficient (Hif1α) and wild-type mice. Read More

    Exploration of knowledge and understanding in patients with primary adrenal insufficiency: a mixed methods study.
    BMC Endocr Disord 2017 Aug 1;17(1):47. Epub 2017 Aug 1.
    School of Nursing, Institute of Clinical Sciences, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK.
    Background: Primary adrenal insufficiency (PAI) is a rare and severe condition requiring lifelong steroid replacement. During acute illness or stressful events, it is important to appropriately adjust glucocorticoid dose; failure to do so may lead to an adrenal crisis. The aim of the study was to explore patients PAI knowledge and understanding of the condition, steroid replacement adjustment during acute illness or stress and provided education. Read More

    A comparative effectiveness study of two culturally competent models of diabetes self-management programming for Latinos from low-income households.
    BMC Endocr Disord 2017 Jul 24;17(1):46. Epub 2017 Jul 24.
    University of New Mexico Health Sciences Center, Albuquerque, USA.
    Background: Diabetes risk is extremely high for Latinos from low-income households. Health guidelines recommend that individuals learn strategies to self-manage their diabetes, but getting people to adopt required lifestyle changes is challenging and many people are not able to prevent their pre-diabetes from escalating or effectively control their diabetes. Systematic reviews show that culturally competent self-management programs can significantly improve diabetes outcomes and different models for culturally competent programming have been developed. Read More

    Case report: rare skeletal manifestations in a child with primary hyperparathyroidism.
    BMC Endocr Disord 2017 Jul 21;17(1):45. Epub 2017 Jul 21.
    Orthopaedic Unit, National Hospital Sri Lanka, Colombo, Sri Lanka.
    Background: Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage due to routine blood investigations. Etiology of PHPT can be due to adenoma, hyperplasia or rarely carcinoma. Read More

    Elevated C-reactive protein, interleukin 6, tumor necrosis factor alpha and glycemic load associated with type 2 diabetes mellitus in rural Thais: a cross-sectional study.
    BMC Endocr Disord 2017 Jul 17;17(1):44. Epub 2017 Jul 17.
    Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Rd, Bangkok, 10400, Thailand.
    Background: The elevated levels of inflammatory markers, including C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL6) are supposed to be associated with type 2 diabetes mellitus (T2DM). Frequent high glycemic load (GL) consumption, central obesity, and a lack of physical activity are considered to be T2DM risk factors. This study aimed to determine the difference of these inflammatory markers as well as GL in individuals with versus those without T2DM in rural Thais. Read More

    Erratum to: Metabolic syndrome and its predictors in an urban population in Kenya: a cross sectional study.
    BMC Endocr Disord 2017 Jul 14;17(1):43. Epub 2017 Jul 14.
    Division of Chemical Pathology, Department of Pathology, Stellenbosch University, Tygerberg Hospital, P.O. Box 19113, Cape Town, South Africa.

    Metabolic characteristics of individuals at a high risk of type 2 diabetes - a comparative cross-sectional study.
    BMC Endocr Disord 2017 Jul 14;17(1):40. Epub 2017 Jul 14.
    The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, 413 45, Gothenburg, Sweden.
    Background: Type 2 diabetes (T2D) is associated with substantial morbidity and mortality. Individuals with a family history of T2D are at an increased risk of developing the disease. The aim of this study was to assess metabolic differences between first-degree relatives (FDR) of T2D patients and persons with no known family history of T2D (non-FDR). Read More

    Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine neoplasms in a Chinese population: a large, retrospective single-centre study.
    BMC Endocr Disord 2017 Jul 13;17(1):39. Epub 2017 Jul 13.
    Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, No.1, East Jianshe Road, Zhengzhou, 450052, China.
    Background: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common type of neuroendocrine tumors, accounting for more than half of neuroendocrine neoplasms (NENs). We performed a retrospective study in our center to investigate the clinicopathological features, risk factors of metastasis, and prognosis of GEP-NENs in a Chinese population.

    Methods: Four hundred forty patients with GEP-NENs treated at the First Affiliated Hospital of Zhengzhou University between January 2011 and March 2016 were analyzed retrospectively. Read More

    Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss.
    BMC Endocr Disord 2017 Jul 14;17(1):41. Epub 2017 Jul 14.
    Department of Diabetes and Endocrinology, University of Hull, Hull, UK.
    Background: Evidence suggests that endocannabinoid system activation through the cannabinoid receptor 1 (CB1) is associated with enhanced liver injury, and CB1 antagonism may be beneficial. The aim of this study was to determine the impact of rimonabant (CB1 antagonist) on alanine aminotransferase (ALT), a hepatocellular injury marker, and a hepatic inflammatory cytokine profile.

    Methods: Post hoc review of 2 studies involving 50 obese women with PCOS and well matched for weight, randomised to weight reducing therapy; rimonabant (20 mg od) or orlistat (120 mg tds), or to insulin sensitising therapy metformin, (500 mg tds), or pioglitazone (45 mg od). Read More

    Health-related quality of life in type-2 diabetes patients: a cross-sectional study in East China.
    BMC Endocr Disord 2017 Jul 6;17(1):38. Epub 2017 Jul 6.
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
    Background: Used the EuroQoL-5 dimension (EQ-5D) to evaluate the health status of 5310 residents who live in East China, and compared the health-related quality of life (HRQoL) with 311 patients with type 2 diabetes as well as to explore the main influence factors to HRQoL in East China.

    Methods: The cohort includes 5310 participants aged 18-89 years old lived in East China. EuroQoL-5 dimension (EQ-5D) scale was used for the assessment of health-related quality of life. Read More

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