159,880 results match your criteria BMC Ear Nose and Throat Disorders [Journal]


miR-1933-3p is upregulated in skeletal muscles of MuSK+ EAMG mice and affects Impa1 and Mrpl27.

Neurosci Res 2019 Feb 11. Epub 2019 Feb 11.

Department of Neuroscience, Clinical Neurophysiology, Uppsala University, BMC, Husargatan 3, Uppsala, Sweden. Electronic address:

MuSK antibody seropositive (MuSK+) Myasthenia Gravis (MG) typically affects skeletal muscles of the bulbar area, including the omohyoid muscle, causing focal fatigue, weakness and atrophy. The profile of circulating extracellular microRNA (miRNA) is changed in MuSK + MG, but the intracellular miRNA profile in skeletal muscles of MuSK + MG and MuSK + experimental autoimmune MG (EAMG) remains unknown. This study elucidated the intracellular miRNA profile in the omohyoid muscle of mice with MuSK + EAMG. Read More

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http://dx.doi.org/10.1016/j.neures.2019.02.003DOI Listing
February 2019

Disrespectful and abusive behavior during childbirth and maternity care in Ethiopia: a systematic review and meta-analysis.

BMC Res Notes 2019 Feb 13;12(1):83. Epub 2019 Feb 13.

School of Medical Laboratory Science, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Objective: Disrespectful and abusive behavior during childbirth and maternity care is violation of fundamental right of women and unborn child. There is scarce of data on disrespectful and abusive behavior during childbirth and maternity care in Ethiopia. The aim of this study was to determine disrespectful and abusive behavior during childbirth and maternity care in Ethiopia. Read More

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http://dx.doi.org/10.1186/s13104-019-4118-2DOI Listing
February 2019

Mobile health in the management of type 1 diabetes: a systematic review and meta-analysis.

BMC Endocr Disord 2019 Feb 13;19(1):21. Epub 2019 Feb 13.

Department of Health Statistics, School of Public Health, Inner Mongolia Medical University, Hohhot, 010110, China.

Background: As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However, the effectiveness of mHealth in controlling the glycemic control remains uncertain. Read More

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http://dx.doi.org/10.1186/s12902-019-0347-6DOI Listing
February 2019

Gorham's disease: treatment with an autologous iliac bone graft and a reverse total shoulder arthroplasty.

BMC Musculoskelet Disord 2019 Feb 13;20(1):73. Epub 2019 Feb 13.

The Department of Orthopedics, North China University of Science and Technology Affiliated Hospital, No.73 Jianshe South Road, Tangshan, Hebei, 063000, People's Republic of China.

Background: Gorham's disease (GSD) is a rare osteolytic disease with unclear etiology, and no known prevention or effective treatment. Here we report a new surgical treatment for a case of GSD in September 2017.

Case Presentation: We report GSD in a 52-year-old woman. Read More

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http://dx.doi.org/10.1186/s12891-019-2436-0DOI Listing
February 2019

Chronodentistry: the role & potential of molecular clocks in oral medicine.

BMC Oral Health 2019 Feb 13;19(1):32. Epub 2019 Feb 13.

Department of Conservative Dentistry and Periodontology, University Clinic of Dentistry, Medical University of Vienna, Sensengasse 2a, 1090, Vienna, Austria.

Molecular clocks help organisms to adapt important physiological functions to periodically changing conditions in the environment. These include the adaption of the 24 h sleep-wake rhythm to changes of day and night. The circadian clock is known to act as a key regulator in processes of health and disease in different organs. Read More

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http://dx.doi.org/10.1186/s12903-019-0720-xDOI Listing
February 2019

Evaluation of a collaborative care approach between general practitioners and clinical pharmacists in primary care community settings in elderly patients on polypharmacy in Slovenia: a cohort retrospective study reveals positive evidence for implementation.

BMC Health Serv Res 2019 Feb 13;19(1):118. Epub 2019 Feb 13.

Faculty of medicine Maribor, University of Maribor, Taborska ulica 8, 2000, Maribor, Slovenia.

Background: The population of developed countries is aging, leading to an increase in the use of medication in daily practice, which can lead to serious treatment costs and irrational polypharmacy. A collaborative care approach, such as providing medication review service provided by a clinical pharmacist (CP), is a possible way to reduce drug-related problems and irrational polypharmacy. The aim of this study was to determinate whether a CP's medication review service can improve the quality of drug prescribing in elderly patients treated with polypharmacy in primary care. Read More

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http://dx.doi.org/10.1186/s12913-019-3942-3DOI Listing
February 2019

Predicting reattendance to the second round of the Maltese national breast screening programme: an analytical descriptive study.

BMC Public Health 2019 Feb 13;19(1):189. Epub 2019 Feb 13.

Highland Campus, Centre for Health Science, Old Perth Road, Inverness, IV2 3JH, UK.

Background: A range of barriers influence women's uptake to a first breast screening invitation. Few studies however, have examined factors associated with second screening uptake. This study follows Maltese women to explore predictors and behaviours to re-attendance, and to determine if uptake of first invitation to the Maltese Breast Screening Programme (MBSP) is a significant predictor of second screening uptake. Read More

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http://dx.doi.org/10.1186/s12889-019-6507-9DOI Listing
February 2019

An epidemiological investigation of porcine circovirus 3 infection in cattle in Shandong province, China.

BMC Vet Res 2019 Feb 13;15(1):60. Epub 2019 Feb 13.

College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.

Background: Porcine circovirus type 3 (PCV3) is a single-stranded, closed circular DNA virus, which causes porcine dermatitis and nephropathy syndrome (PDNS), multisystemic inflammation, and reproductive failure. The present study aimed to investigate the seroprevalence of PCV3 in cattle (Bos taurus) in Shandong province, China, and examine its genome diversity.

Results: PCR amplification and sequencing showed that 74 of 213 bovine samples (34. Read More

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http://dx.doi.org/10.1186/s12917-019-1793-0DOI Listing
February 2019

Environmental correlates of physical activity among children 10 to 13 years old in Wallonia (Belgium).

BMC Public Health 2019 Feb 13;19(1):187. Epub 2019 Feb 13.

Service d'Information Promotion Éducation Santé (SIPES), Research Center in Epidemiology, Biostatistics and Clinical Research, School of Public Health, Université libre de Bruxelles (ULB), Postal address: ULB CP598, Route de Lennik 808, B-1070, Brussels, Belgium.

Background: In Belgium, as in many other countries, the juvenile practice of physical activity is insufficient. A growing attention has been paid to environmental factors that may influence physical activity but with inconsistent findings. This study aims to estimate the association between daily life environment characteristics and physical activity among children 10 to 13 years old in Wallonia (Belgium). Read More

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http://dx.doi.org/10.1186/s12889-019-6509-7DOI Listing
February 2019

High-throughput, non-invasive prenatal testing for fetal rhesus D status in RhD-negative women: a systematic review and meta-analysis.

BMC Med 2019 Feb 14;17(1):37. Epub 2019 Feb 14.

Centre for Reviews and Dissemination, University of York, York, YO10 5DD, UK.

Background: High-throughput non-invasive prenatal testing (NIPT) for fetal Rhesus D (RhD) status could avoid unnecessary treatment with anti-D immunoglobulin for RhD-negative women found to be carrying an RhD-negative fetus. We aimed to assess the diagnostic accuracy of high-throughput NIPT for fetal RhD status in RhD-negative women not known to be sensitized to the RhD antigen, by performing a systematic review and meta-analysis.

Methods: Prospective cohort studies of high-throughput NIPT used to determine fetal RhD status were included. Read More

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http://dx.doi.org/10.1186/s12916-019-1254-4DOI Listing
February 2019

Correction to: characterizing active transportation mechanisms for free fatty acids and antibiotics in Synechocystis sp. PCC 6803.

BMC Biotechnol 2019 Feb 13;19(1):12. Epub 2019 Feb 13.

School of Life Sciences, Arizona State University, 427 E. Tyler Mall, Tempe, AZ, 85287, USA.

Following publication of the original article [1], the author reported that the gene/protein names of slr2131 and sll0180 were swapped in the Discussion section. The details of the correction are mentioned below. Read More

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http://dx.doi.org/10.1186/s12896-019-0505-yDOI Listing
February 2019

Multi-targeting chemoprevention of Chinese herb formula Yanghe Huayan decoction on experimentally induced mammary tumorigenesis.

BMC Complement Altern Med 2019 Feb 13;19(1):48. Epub 2019 Feb 13.

Affiliated Hospital of Taishan Medical University, Taian, 271000, Shandong, China.

Background: Development of safe and effective chemopreventive agents is a winning strategy in reducing the morbidity and mortality of breast cancer. The current study was to investigate the mechanism-based chemopreventive potential of a Chinese herb formula Yanghe Huayan (YHHY) Decoction on the classical 7,12-dimethylbenz(a)anthracene (DMBA) induced rat mammary carcinogenesis model.

Methods: Female Sprague-Dawley rats at 42 days of age were orally administered with a human equivalent dose of YHHY Decoction at 0. Read More

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http://dx.doi.org/10.1186/s12906-019-2456-1DOI Listing
February 2019

Adherence to standard nursing protocols on nasogastric tube feeding in a secondary referral hospital in Ghana: comparing self-ratings by professional and auxiliary nurses.

BMC Health Serv Res 2019 Feb 13;19(1):119. Epub 2019 Feb 13.

Department of Midwifery, School of Nurising and Midwifery, University of Health and Allied Sciences, Ho, Ghana.

Background: Data on nurses' adherence to standard protocol on nasogastric (NG) tube feeding remain scanty in Ghana even though patients in critical medical conditions are routinely managed using this procedure. This study explored self-rated adherence to standard protocols on NG tube feeding among professional and auxiliary nurses and the perceived barriers impeding compliance to these standard protocols.

Methods: This is a descriptive analytical cross-sectional study among professional (n = 89) and auxiliary (n = 24) nurses in a major referral hospital in one of the ten administrative regions in Ghana. Read More

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http://dx.doi.org/10.1186/s12913-019-3931-6DOI Listing
February 2019

Healthcare workers' experiences regarding scaling up of training on integrated disease surveillance and response (IDSR) in Uganda, 2016: cross sectional qualitative study.

BMC Health Serv Res 2019 Feb 13;19(1):117. Epub 2019 Feb 13.

World Health Organization Africa Regional Office, Brazzaville, Congo.

Background: The Integrated Disease Surveillance and Response (IDSR) strategy was adopted as the framework for implementation of International Health Regulation (2005) in the African region of World Health Organisation (WHO AFRO). While earlier studies documented gains in performance of core IDSR functions, Uganda still faces challenges due to infectious diseases. IDSR revitalisation programme aimed to improve prevention, early detection, and prompt response to disease outbreaks. Read More

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http://dx.doi.org/10.1186/s12913-019-3923-6DOI Listing
February 2019

Asthma and atopy prevalence are not reduced among former tuberculosis patients compared with controls in Lima, Peru.

BMC Pulm Med 2019 Feb 13;19(1):40. Epub 2019 Feb 13.

The University of Sydney, St. Vincent's Hospital Sydney, Heart Lung Clinic, Xavier Building. 390, Victoria Street, 2010, Australia.

Background: Although there are theoretical reasons for believing that asthma and atopy may be negatively correlated with tuberculosis, epidemiological studies have had conflicting findings.

Objective: To determine if people with confirmed tuberculosis were less likely to be atopic and less likely to have atopic disease including asthma compared to those with no previous tuberculosis.

Methods: Patients in Lima, Peru with a prior history of tuberculosis were identified from clinic records in this cohort study. Read More

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http://dx.doi.org/10.1186/s12890-019-0804-zDOI Listing
February 2019

Acceptability and feasibility of delegating HIV counseling and testing for TB patients to community health workers in the Philippines: a mixed methods study.

BMC Public Health 2019 Feb 13;19(1):185. Epub 2019 Feb 13.

Department of Biostatistics, Epidemiology, and Population Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta City, 55281, Indonesia.

Background: The Philippines has a high burden of TB and HIV, yet the WHO estimates that only 13% of Filipino TB patients know their HIV status. This is partly attributable to the lack of trained HIV counselors and medical technologists (or laboratory technicians) at the primary healthcare level. In Africa where resources and manpower are also scarce, TB/HIV care is already delegated to community health workers. Read More

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http://dx.doi.org/10.1186/s12889-019-6497-7DOI Listing
February 2019

Effects of mobilisation with movement (MWM) on anatomical and clinical characteristics of chronic ankle instability: a randomised controlled trial protocol.

BMC Musculoskelet Disord 2019 Feb 13;20(1):75. Epub 2019 Feb 13.

School of Health Sciences, Faculty of Health and Medicine, The University of Newcastle, Callaghan, Australia.

Background: Up to 40% of individuals who sprain their ankle develop chronic ankle instability (CAI). One treatment option for this debilitating condition is joint mobilisation. There is preliminary evidence that Mulligan's Mobilisation With Movement (MWM) is effective for treating patients with CAI, but the mechanisms by which it works are unclear, with Mulligan suggesting a repositioning of the fibula. Read More

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http://dx.doi.org/10.1186/s12891-019-2447-xDOI Listing
February 2019

Improving oral health in migrant and underserved populations: evaluation of an interactive, community-based oral health education program in Washington state.

BMC Oral Health 2019 Feb 13;19(1):30. Epub 2019 Feb 13.

Andy Hill Cancer Research Endowment, Seattle, WA, USA.

Objectives: Oral health is one of the greatest unmet health needs of migrant farmworkers and many migrant workers lack basic oral health knowledge. This paper presents evaluation results for an oral health education program designed to both increase knowledge concerning oral health practices and to gain a better understanding of the knowledge, attitudes and behaviors regarding oral health among migrant workers.

Methods: We used a pre-post uncontrolled design to assess the impact of the education program on participant knowledge about oral health practices. Read More

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http://dx.doi.org/10.1186/s12903-019-0723-7DOI Listing
February 2019

Predictors of self-perceived cultural responsiveness in entry-level physiotherapy students in Australia and Aotearoa New Zealand.

BMC Med Educ 2019 Feb 13;19(1):56. Epub 2019 Feb 13.

School of Science and Health, Western Sydney University, Penrith, NSW, 2751, Australia.

Background: Ensuring physiotherapy students are well prepared to work safely and effectively in culturally diverse societies upon graduation is vital. Therefore, determining whether physiotherapy programs are effectively developing the cultural responsiveness of students is essential. This study aimed to evaluate the level of self-perceived cultural responsiveness of entry level physiotherapy students during their training, and explore the factors that might be associated with these levels. Read More

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http://dx.doi.org/10.1186/s12909-019-1487-0DOI Listing
February 2019

Developing strategic priorities in osteoarthritis research: Proceedings and recommendations arising from the 2017 Australian Osteoarthritis Summit.

BMC Musculoskelet Disord 2019 Feb 13;20(1):74. Epub 2019 Feb 13.

Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, Australia.

Background: There is a pressing need to enhance osteoarthritis (OA) research to find ways of alleviating its enormous individual and societal impact due to the high prevalence, associated disability, and extensive costs.

Methods: Potential research priorities and initial rankings were pre-identified via surveys and the 1000Minds process by OA consumers and the research community. The OA Summit was held to decide key research priorities that match the strengths and expertise of the Australian OA research community and align with the needs of consumers. Read More

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http://dx.doi.org/10.1186/s12891-019-2455-xDOI Listing
February 2019

Stress on facial skin of class III subjects during maxillary protraction: a finite element analysis.

BMC Oral Health 2019 Feb 13;19(1):31. Epub 2019 Feb 13.

Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Via Collazia 29, 00183, Rome, Italy.

Background: Maxillary protraction with facemask (FM) is an orthopedic approach for treatment of Class III growing patients. Aim of the present investigation was to analyze tension loads produced by two different facial mask (FM) designs on facial skin of subject with skeletal Class III.

Methods: A three-dimensional (3D) geometry of Delaire and Petit FM models were reconstructed from the original Computer Aided Design (CAD) 3D prototype using software package (ANSYS 5. Read More

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http://dx.doi.org/10.1186/s12903-019-0724-6DOI Listing
February 2019

Improved long-term survival with home hemodialysis compared with institutional hemodialysis and peritoneal dialysis: a matched cohort study.

BMC Nephrol 2019 Feb 13;20(1):52. Epub 2019 Feb 13.

Department of Clinical Sciences Lund, University, Skane University Hospital, Nephrology Lund, Lund, Sweden.

Background: The survival rate for dialysis patients is poor. Previous studies have shown improved survival with home hemodialysis (HHD), but this could be due to patient selection, since HHD patients tend to be younger and healthier. The aim of the present study is to analyse the long-term effects of HHD on patient survival and on subsequent renal transplantation, compared with institutional hemodialysis (IHD) and peritoneal dialysis (PD), taking age and comorbidity into account. Read More

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http://dx.doi.org/10.1186/s12882-019-1245-xDOI Listing
February 2019

A stepped wedge cluster randomised trial of a cognitive remediation intervention in alcohol and other drug (AOD) residential treatment services.

BMC Psychiatry 2019 Feb 13;19(1):70. Epub 2019 Feb 13.

Ministry of Health NSW, 73 Miller St, North Sydney, NSW, 2060, Australia.

Background: Executive functioning impairment is common in substance use disorder and is a major risk factor for poor treatment outcomes, including treatment drop-out and relapse. Cognitive remediation interventions seek to improve executive functioning and offer a promising approach to increase the efficacy of alcohol and other drug (AOD) treatments and improve long-term therapeutic outcomes. This protocol describes a study funded by the NSW Agency for Clinical Innovation that assesses the effectiveness of delivering a six-week group-based intervention of cognitive remediation in an ecologically valid sample of people attending residential AOD treatment services. Read More

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http://dx.doi.org/10.1186/s12888-019-2044-4DOI Listing
February 2019

Migraine and increased risk of developing open angle glaucoma: a population-based cohort study.

BMC Ophthalmol 2019 Feb 13;19(1):50. Epub 2019 Feb 13.

Department of Ophthalmology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.

Background: Migraine is linked to endothelial dysfunction and is considered to be a systemic vasculopathy. Interestingly, systemic vascular diseases also occur in glaucoma patients and are considered to be vascular risk factors. Whether migraine is simply a concomitant condition in glaucoma patients or a risk factor per se for glaucoma remains unknown. Read More

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http://dx.doi.org/10.1186/s12886-019-1062-9DOI Listing
February 2019

EQUIPTT: The Evaluation of the QUiPP app for Triage and Transfer protocol for a cluster randomised trial to evaluate the impact of the QUiPP app on inappropriate management for threatened preterm labour.

BMC Pregnancy Childbirth 2019 Feb 13;19(1):68. Epub 2019 Feb 13.

Division of Women's Health, Faculty of Life Sciences & Medicine, King's College London, 10th Floor, North Wing, St Thomas's Hospital Campus, London, SE1 7EH, UK.

Background: Accurate diagnosis of preterm labour is needed to ensure correct management of those most at risk of preterm birth and to prevent the maternal and fetal risks incurred by unnecessary interventions given to the large majority of women, who do not deliver within a week of presentation. Intervention "just-in-case" results in many avoidable admissions, women being transferred out of their local hospital unnecessarily and most women receiving unwarranted drugs, such as steroids and tocolytics. It also precludes appropriate transfers for others as neonatal cots are blocked pre-emptively, resulting in more dangerous ex-utero transfers. Read More

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http://dx.doi.org/10.1186/s12884-019-2210-1DOI Listing
February 2019

Levels of vitamin D-associated cytokines distinguish between active and latent tuberculosis following a tuberculosis outbreak.

BMC Infect Dis 2019 Feb 13;19(1):151. Epub 2019 Feb 13.

Lung Research Institute of Hallym University College of Medicine, Chuncheon, Gangwon-do, Republic of Korea.

Background: Vitamin D levels are associated with the extent of mycobactericidal activity. Interleukin (IL)-15 and IL-32 play roles in the vitamin D-mediated tuberculosis (TB) defense mechanism. Vitamin D induces IL-1β, which plays an important role in terms of resistance to TB. Read More

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http://dx.doi.org/10.1186/s12879-019-3798-5DOI Listing
February 2019

Protocol for a cross sectional study of cancer risk, environmental exposures and lifestyle behaviors in a diverse community sample: the Community of Mine study.

BMC Public Health 2019 Feb 13;19(1):186. Epub 2019 Feb 13.

Department of Family Medicine and Public Health, UCSD, 9500 Gilman Dr, La Jolla, CA, 92093, USA.

Background: Physical inactivity and unhealthy diet are modifiable behaviors that lead to several cancers. Biologically, these behaviors are linked to cancer through obesity-related insulin resistance, inflammation, and oxidative stress. Individual strategies to change physical activity and diet are often short lived with limited effects. Read More

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http://dx.doi.org/10.1186/s12889-019-6501-2DOI Listing
February 2019

Long-term survival and prognostic factors for locally advanced renal cell carcinoma with renal vein tumor thrombus.

BMC Cancer 2019 Feb 13;19(1):144. Epub 2019 Feb 13.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Panjiayuan Nanli 17#, Chaoyang District, 100021, People's Republic of China.

Background: Previous related studies have mainly focused on renal cell carcinoma (RCC) with venous tumor thrombus, specifically inferior vena cava tumor thrombus with renal vein tumor thrombus (RVTT). However, only a few studies have focused on postoperative long-term survival of RCC patients exclusively with RVTT. Our aim was to investigate the independent prognostic factors for locally advanced RCC with RVTT in China. Read More

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http://dx.doi.org/10.1186/s12885-019-5359-0DOI Listing
February 2019

NK and NKT cells in the diagnosis of diffuse lung diseases presenting with a lymphocytic alveolitis.

BMC Pulm Med 2019 Feb 13;19(1):39. Epub 2019 Feb 13.

Department of Pulmonology, Hospital de São João and Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Diffuse lung diseases (DLD) are characterized by different immunophenotypes in the bronchoalveolar lavage fluid (BALF). We aimed to evaluate the diagnostic value of BALF NK and NKT cell counts of patients with DLD and lymphocytic alveolitis.

Methods: We assessed 202 patients with DLD, who underwent BALF immunophenotyping. Read More

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http://dx.doi.org/10.1186/s12890-019-0802-1DOI Listing
February 2019

A cluster randomised controlled trial of an intervention to increase the implementation of school physical activity policies and guidelines: study protocol for the physically active children in education (PACE) study.

BMC Public Health 2019 Feb 11;19(1):170. Epub 2019 Feb 11.

Hunter New England Population Health, Hunter New England Area Health Service, Newcastle, Australia.

Background: In an attempt to improve children's physical activity levels governments have introduced policies specifying the minimum time schools are to schedule physical activity each week. Despite this, the majority of schools in many jurisdictions fail to implement these policies. This study will assess the effectiveness of a multi-component implementation strategy on increasing the minutes of planned physical activity scheduled by primary school teachers each week. Read More

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http://dx.doi.org/10.1186/s12889-019-6492-zDOI Listing
February 2019

Sleep disorders associated with risk of prostate cancer: a population-based cohort study.

BMC Cancer 2019 Feb 13;19(1):146. Epub 2019 Feb 13.

Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.

Background: Disrupted sleep rhythms may lead to cancer development. We conducted a population-based cohort study to evaluate the incidence and risk of prostate cancer in patients with sleep disorders (SDs).

Methods: Patients newly diagnosed with SDs between 2000 and 2010 were enrolled from the Taiwan Longitudinal Health Insurance Database. Read More

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http://dx.doi.org/10.1186/s12885-019-5361-6DOI Listing
February 2019

Cannabidiol enhancement of exposure therapy in treatment refractory patients with phobias: study protocol of a randomized controlled trial.

BMC Psychiatry 2019 Feb 13;19(1):69. Epub 2019 Feb 13.

Department of Experimental Psychology and Helmholtz Institute, Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands.

Background: Phobic anxiety disorders are among the most prevalent psychiatric disorders and are burdensome in terms of loss of quality of life and work productivity. Evidence-based treatments are relatively successful in the majority of patients, especially exposure therapy. However, a substantial subset of patients fails to achieve or stay in remission. Read More

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https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12888-019-2022-xDOI Listing
February 2019
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Evaluation of lifestyle of female adolescents through latent class analysis approach.

BMC Public Health 2019 Feb 13;19(1):184. Epub 2019 Feb 13.

Programa de Pós-Graduação em Ciência da Nutrição, Viçosa, Brasil.

Background: Lack of regular physical activity, high sedentary behavior and presence of unbalanced alimentary practices are attitudes associated with an inadequate lifestyle among female adolescents.

Objective: to assess the lifestyle of female adolescents based on measurements of behavioral variables.

Methods: Cross-sectional study with 405 female adolescents between 14 and 19 years old, resident and attending public schools in Viçosa (state of Minas Gerais). Read More

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http://dx.doi.org/10.1186/s12889-019-6488-8DOI Listing
February 2019

Zika virus infection in Malaysia: an epidemiological, clinical and virological analysis.

BMC Infect Dis 2019 Feb 13;19(1):152. Epub 2019 Feb 13.

Healthcare Statistics Unit, National Clinical Research Centre, Ministry of Health Malaysia, Level 4, Block B4, National Institute of Health, Jalan Setia Murni U13/52, Seksyen U13, 40170, Shah Alam, Selangor Darul Ehsan, Malaysia.

Background: A major outbreak of the Zika virus (ZIKV) has been reported in Brazil in 2015. Since then, it spread further to other countries in the Americas and resulted in declaration of the Public Health Emergency of International Concern (PHEIC) by World Health Organization. In 2016, Singapore reported its first minor ZIKV epidemic. Read More

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http://dx.doi.org/10.1186/s12879-019-3786-9DOI Listing
February 2019

Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation.

BMC Cancer 2019 Feb 13;19(1):148. Epub 2019 Feb 13.

Division of Pulmonology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Background: A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. However, hypoxia-induced changes in the expression and function of candidate stem cell markers and their possible molecular mechanism is still not understood.

Methods: Lung cell lines were analyzed in normoxic or hypoxic conditions. Read More

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http://dx.doi.org/10.1186/s12885-019-5360-7DOI Listing
February 2019

Evaluation of Get Healthy at Work, a state-wide workplace health promotion program in Australia.

BMC Public Health 2019 Feb 13;19(1):183. Epub 2019 Feb 13.

Prevention Research Collaboration, The Charles Perkins Centre, Sydney School of Public Health, The University of Sydney, Sydney, NSW, 2006, Australia.

Background: Workplace health programs (WHPs) may improve adult health but very little evidence exists on multi-level WHPs implemented at-scale and so the relationship between program implementation factors and outcomes of WHPs are poorly understood. This study evaluated Get Healthy at Work (GHaW), a state-wide government-funded WHP in Australia.

Methods: A mixed-method design included a longitudinal quasi-experimental survey of businesses registered with GHaW and a comparison group of businesses surveyed over a 12-month period. Read More

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http://dx.doi.org/10.1186/s12889-019-6493-yDOI Listing
February 2019

Correction to: The elevated levels of urinary angiotensinogen are correlated with the severity of idiopathic membranous nephropathy.

BMC Nephrol 2019 Feb 13;20(1):50. Epub 2019 Feb 13.

Department of Nephrology, Peking University Third Hospital, No. 49, North Garden Road, Haidian District, Beijing, 100191, China.

Following publication of the original article [1], it was reported that, due to a typesetting mistake, the three tables and two figures for this article were included as an Additional file instead of in the body of the article. The original publication of this article has been updated to correct this. Read More

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http://dx.doi.org/10.1186/s12882-019-1229-xDOI Listing
February 2019

Post renal transplant anemia: severity, causes and their association with graft and patient survival.

BMC Nephrol 2019 Feb 13;20(1):51. Epub 2019 Feb 13.

Department of Nephrology and Hypertension, Rabin Medical Center, Petah Tikva, Israel.

Background: Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased mortality. However, the effect of the severity of anemia on this associations was not thoroughly evaluated. Read More

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http://dx.doi.org/10.1186/s12882-019-1244-yDOI Listing
February 2019

What he knows about her and how it affects her? Husband's knowledge of pregnancy complications and maternal health care utilization among tribal population in Maharashtra, India.

BMC Pregnancy Childbirth 2019 Feb 13;19(1):70. Epub 2019 Feb 13.

Department of Population Policies and Programmes, International Institute for Population Sciences, Mumbai, India.

Background: Husbands' knowledge and awareness of pregnancy complications have a positive impact on their wives' utilization of maternal health care services. In this study, we examined whether husbands' knowledge and awareness of pregnancy complications can serve as determinants of maternal health service utilization among wives from the tribal population.

Methods: This cross-sectional study was conducted in the rural Gadchrioli district of Maharashtra, India, during November 2014-March 2015. Read More

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http://dx.doi.org/10.1186/s12884-019-2214-xDOI Listing
February 2019

Mental distress and associated factors among Aksum University students, Ethiopia: a cross-sectional study.

BMC Psychiatry 2019 Feb 13;19(1):71. Epub 2019 Feb 13.

Department of Psychiatric Nursing, Aksum University College of Health Science, Referral Hospital, P.O. Box: 1010, Aksum, Ethiopia.

Background: Mental distress is becoming a common health problem in Ethiopia. The prevalence of mental distress is higher among university students than the general population. However, there is inadequate information in this regard in Ethiopia situations. Read More

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http://dx.doi.org/10.1186/s12888-019-2051-5DOI Listing
February 2019

A case report of a teenager with severe hand, foot, and mouth disease with brainstem encephalitis caused by enterovirus 71.

BMC Pediatr 2019 Feb 13;19(1):59. Epub 2019 Feb 13.

Intensive Care Unit, Key Medical Laboratory of Pediatrics, Chongqing Health Bureau, Ministry of Education; Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Hand, foot, and mouth disease (HFMD) is an acute viral infection occurring mostly in infants and children. Enterovirus 71 (EV71) infection mostly occurs in children < 5 years of age. Severe cases, however, are usually encountered in children under the age of 3 years, and exceedingly rare in teenagers > 14 years and adults. Read More

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http://dx.doi.org/10.1186/s12887-019-1428-4DOI Listing
February 2019

The Dynamic Work study: study protocol of a cluster randomized controlled trial of an occupational health intervention aimed at reducing sitting time in office workers.

BMC Public Health 2019 Feb 13;19(1):188. Epub 2019 Feb 13.

Department of Public and Occupational Health, Amsterdam Public Health research institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081BT, Amsterdam, The Netherlands.

Background: Large volumes of sitting time have been associated with multiple health risks. To reduce sitting time of office workers working for a Dutch insurance company, the Dynamic Work intervention was developed. The primary objective of this paper is to describe the study protocol of the Dynamic Work study, which aims to evaluate if this multicomponent intervention is (cost-)effective in reducing total sitting time on the short-term (≈3 months) and longer-term (≈12 months) compared to usual practice. Read More

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http://dx.doi.org/10.1186/s12889-019-6467-0DOI Listing
February 2019

Macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium in Johannesburg, South Africa, 2007-2014.

BMC Infect Dis 2019 Feb 13;19(1):148. Epub 2019 Feb 13.

Sexually Transmitted Infections Section, Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.

Background: Antimicrobial resistance in Mycoplasma genitalium is rising globally with resultant clinical treatment failure. We investigated the prevalence of mutations in the macrolide and fluoroquinolone resistance-determining regions of M. genitalium in Johannesburg, South Africa, and ascertained their association with HIV serostatus. Read More

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http://dx.doi.org/10.1186/s12879-019-3797-6DOI Listing
February 2019

Patient satisfaction of radiofrequency ablation for symptomatic benign solid thyroid nodules: our experience for 2-year follow up.

BMC Cancer 2019 Feb 13;19(1):147. Epub 2019 Feb 13.

Department of Ultrasound, Beijing Tian Tan Hospital, Capital Medical University, No. 119 West Road of South 4th Ring Road, Fengtai District, Beijing, 100160, China.

Background: The patient satisfaction of symptoms improvement and disease factors that may affect long-term treatment efficacy of radiofrequency ablation (RFA) for non-functioning solid benign thyroid nodules (TNs) over a 2-year follow up study was investigated.

Methods: This retrospective study evaluated 194 non-functioning solid benign TNs of 103 patients. The TNs were categorized as small (≤5 ml), medium (5. Read More

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http://dx.doi.org/10.1186/s12885-019-5338-5DOI Listing
February 2019

Prevalence and intensity of Loa loa infection over twenty-three years in three communities of the Mbalmayo health district (Central Cameroon).

BMC Infect Dis 2019 Feb 13;19(1):146. Epub 2019 Feb 13.

Centre for Research on Filariasis and other Tropical Diseases, PO Box 5797, Yaounde, Cameroon.

Background: Loiasis is a vector-borne parasitic disease due to Loa loa and transmitted to humans by tabanids of the genus Chrysops. Loiasis has been historically considered as the second or third most common reason for medical consultation after malaria, and a recent study has reported an excess mortality associated with the infection. However, the clinical impact of this filarial disease is yet to be elucidated, and it is still considered a benign disease eliciting very little attention. Read More

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http://dx.doi.org/10.1186/s12879-019-3776-yDOI Listing
February 2019

The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis.

BMC Cancer 2019 Feb 13;19(1):145. Epub 2019 Feb 13.

Department of Surgical Oncology, First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, China.

Background: The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and overall survival (OS) in NSCLC patients with brain metastases.

Methods: Searches were performed in PubMed, EmBase, and the Cochrane Library to identify studies evaluating the association of EGFR mutation with OS in NSCLC patients through September 2017. Read More

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http://dx.doi.org/10.1186/s12885-019-5331-zDOI Listing
February 2019

Determinants of early initiation of breastfeeding in Ethiopia: a population-based study using the 2016 demographic and health survey data.

BMC Pregnancy Childbirth 2019 Feb 13;19(1):69. Epub 2019 Feb 13.

School of Science and Health, Western Sydney University, Campbelltown, NSW, Australia.

Background: Timely breastfeeding initiation is a simple but important measure that has protective effects on infants and mothers. This study aims to determine the predictors of early breastfeeding initiation among mothers residing in Ethiopia.

Methods: This study employed the 2016 Ethiopian Demographic and Health Survey data. Read More

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http://dx.doi.org/10.1186/s12884-019-2211-0DOI Listing
February 2019

Is Interleukin-6 a better predictor of successful antibiotic therapy than procalcitonin and C-reactive protein? A single center study in critically ill adults.

BMC Infect Dis 2019 Feb 13;19(1):150. Epub 2019 Feb 13.

Medical Intensive Care Unit, University Hospital of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.

Background: The aim of this study was to evaluate whether Interleukin-6 (IL-6) could be a faster indicator of treatment success in adults with severe sepsis and septic shock compared to procalcitonin (PCT) and C-reactive protein (CRP).

Methods: Data from adult patients with severe sepsis and septic shock managed at the medical intensive care unit (ICU) of the University Hospital Leipzig between September 2009 and January 2012 were analyzed retrospectively. Values for CRP, PCT and IL-6 on admission as well as after 24 and 48-72 h were collected. Read More

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http://dx.doi.org/10.1186/s12879-019-3800-2DOI Listing
February 2019

Using fetal scalp stimulation with Doppler ultrasonography to enhance intermittent auscultation in low-resource settings: a diagnostic trial from Tanzania.

BMC Pregnancy Childbirth 2019 Feb 13;19(1):71. Epub 2019 Feb 13.

Hubert-Yeargan Center for Global Health, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.

Background: Hypoxia during labor contributes to 2.2 million intrapartum and early neonatal deaths each year. An additional 0. Read More

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http://dx.doi.org/10.1186/s12884-019-2212-zDOI Listing
February 2019

Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice.

BMC Cancer 2019 Feb 13;19(1):149. Epub 2019 Feb 13.

Division of RI application, Korea Institute of Radiological and Medical Sciences, 75 Nowon-Gil, Gongneung-Dong, Nowon-Gu, Seoul, 01812, Korea.

Background: Chemotherapy-induced alopecia has been well documented as a cause of distress to patients undergoing cancer treatment. Almost all traditional chemotherapeutic agents cause severe alopecia. Despite advances in the treatment of chemotherapy-induced alopecia, there is no effective treatment for preventing chemotherapy-induced alopecia. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5323-zDOI Listing
February 2019
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