237 results match your criteria BMC Dermatology[Journal]


Pattern of skin diseases in children attending a dermatology clinic in a referral hospital in Wolaita Sodo, southern Ethiopia.

BMC Dermatol 2019 04 8;19(1). Epub 2019 Apr 8.

College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Background: Epidemiological studies to determine the pattern of skin diseases among children are important for proper health care planning and management. The purpose of this study was to describe the pattern of skin diseases among pediatric patients seen at a dermatology outpatient clinic of Wolaita Sodo Teaching and Referral Hospital, southern Ethiopia.

Method: We conducted a retrospective hospital-based, cross-sectional study between January 2016 and December 2017 at a teaching and referral hospital dermatology outpatient department. Read More

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http://dx.doi.org/10.1186/s12895-019-0085-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454754PMC
April 2019
1 Read

A novel elastin gene frameshift mutation in a Russian family with cutis laxa: a case report.

BMC Dermatol 2019 01 31;19(1). Epub 2019 Jan 31.

Pirogov Russian National Research Medical University, Ostrovitianova street 1, 117997, Moscow, Russia.

Background: Cutis laxa (CL) is a rare connective tissue disorder characterized by loose, redundant, inelastic and wrinkled skin. Patients develop a prematurely aged appearance. Inheritance can be autosomal dominant or autosomal recessive. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-019-0084-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357400PMC
January 2019
12 Reads

Mucous membrane pemphigoid-associated paronychia with onychomadesis.

BMC Dermatol 2019 01 23;19(1). Epub 2019 Jan 23.

Dermatology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease that is notoriously difficult to treat. Nail involvement in MMP is rare.

Case Presentation: We report on a 58 years old man with severe MMP who presented with onychomadesis. Read More

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http://dx.doi.org/10.1186/s12895-019-0083-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343326PMC
January 2019
1 Read

Proderm technology: a water- based lipid delivery system for dermatitis that penetrates viable epidermis and has antibacterial effects.

BMC Dermatol 2019 01 22;19(1). Epub 2019 Jan 22.

Department of Dermatology, University of California San Francisco, San Francisco, California, USA.

Background: A defective skin barrier and bacterial colonization are two important factors in maintenance and progression of atopic dermatitis and chronic allergic/irritant hand dermatitis. A water-based lipid delivery system containing physiologic lipids was previously shown to be a useful adjunct in the treatment of hand dermatitis. We tested the ability of this formulation to penetrate into the viable epidermis and in addition assessed its antibacterial properties. Read More

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http://dx.doi.org/10.1186/s12895-019-0082-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343233PMC
January 2019

Differences in microRNA expression between melanoma and healthy adjacent skin.

BMC Dermatol 2019 01 5;19(1). Epub 2019 Jan 5.

Department of Pathophysiology, Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.

Background: The tumor microenvironment is composed of cancer-associated fibroblasts, tumor-associated macrophages, endothelial cells, immune cells, signaling molecules and extracellular matrix structures, which closelycommunicate with the tumor via multiple mechanisms. MicroRNAs are paracrine regulators that provide a direct interaction between the microenvironment and cancer cells. In the presentstudy, we aimed to identify the microRNA expression profile in melanoma compared with thatin healthy adjacent skin, with a further assessment of altered microRNA signaling pathways and target genes. Read More

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http://dx.doi.org/10.1186/s12895-018-0081-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321655PMC
January 2019
2 Reads

Interdisciplinary and multiprofessional outpatient secondary individual prevention of work-related skin diseases in the metalworking industry: 1-year follow-up of a patient cohort.

BMC Dermatol 2018 12 12;18(1):12. Epub 2018 Dec 12.

Department of Dermatology, Klinikum Dortmund gGmbH, Beurhausstr. 40, 44137, Dortmund, Germany.

Background: In Germany, work-related skin diseases are predominant within the spectrum of reported occupational diseases. Metal workers are among the high-risk professions. Offering effective prevention programs to affected patients is of utmost importance to avoid deterioration of the disease and job loss. Read More

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http://dx.doi.org/10.1186/s12895-018-0080-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292163PMC
December 2018
2 Reads

Assessing skin disease and associated health-related quality of life in a rural Lao community.

BMC Dermatol 2018 12 4;18(1):11. Epub 2018 Dec 4.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology laboratory, Mahosot Hospital, Vientiane, Laos.

Background: Skin diseases are common and often have an impact on an individual's health-related quality of life. In rural communities where access to healthcare may be limited and individuals rely on farming for food and income, the impact of skin diseases may be greater. The objectives for this study were to perform an assessment of skin disease prevalence in a rural village in Laos and assess the associated impact of any skin disease found using the Dermatology Life Quality Index (DLQI). Read More

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http://dx.doi.org/10.1186/s12895-018-0079-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278038PMC
December 2018
19 Reads

Exploratory study of the reproducibility of the SCore for INtrinsic and EXtrinsic skin aging (SCINEXA) scale in "Ruta Escondida de la Mitad del Mundo", Ecuador, 2017.

BMC Dermatol 2018 11 6;18(1):10. Epub 2018 Nov 6.

Ministry of Public Health, Quito, Ecuador.

Background: Few studies have been published related to the analysis of different skin aging parameters for whole-body skin using the SCINEXA scale for skin damage. The aim of this study was to evaluate the reproducibility of the SCINEXA scale (SCore for INtrinsic and EXtrinsic skin Aging) in South-Americans non-Caucasian population of a region of Ecuador.

Methods: Exploratory observational study. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-018-0078-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219042PMC
November 2018
12 Reads

Cost and effectiveness of prescribing emollient therapy for atopic eczema in UK primary care in children and adults: a large retrospective analysis of the Clinical Practice Research Datalink.

BMC Dermatol 2018 10 29;18(1). Epub 2018 Oct 29.

NHS Wakefield Clinical Commissioning Group, West Yorkshire, UK.

Background: The Clinical Practice Research Datalink (CPRD) was used to evaluate the overall costs to the National Health Service, including healthcare utilisation, of prescribing emollients in UK primary care for dry skin and atopic eczema (DS&E).

Methods: Primary care patients in the UK were identified using the CPRD and their records were interrogated for the 2 years following first diagnosis of DS&E. Data from patients with (n = 45,218) and without emollient prescriptions (n = 9780) were evaluated. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-018-0076-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206824PMC
October 2018
12 Reads

Patient-reported outcomes in urticarial vasculitis treated with omalizumab: case report.

BMC Dermatol 2018 10 25;18(1). Epub 2018 Oct 25.

Respiralab, Respiralab Research Group, Guayaquil, Ecuador.

Background: Despite the current knowledge of UV, there is a lack of consensus among diagnostic criteria and management. In general, antihistamine therapy is regularly used for the symptomatic management of pruritus but does not control inflammation or alter the course of the disease. Monoclonal antibodies such as omalizumab (anti-IgE) have been proposed as a potential treatment for urticarial vasculitis. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-018-0077-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203196PMC
October 2018
19 Reads

Acne in Lomé, Togo: clinical aspects and quality of life of patients.

BMC Dermatol 2018 08 22;18(1). Epub 2018 Aug 22.

Dermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, B.P, 30785, Lomé, Togo.

Background: Acne is a chronic inflammatory condition affecting the pilosebaceous follicle that mainly affects adolescents and young adults. The aim of this study was to assess the quality of life (QOL) of patients with acne, and to determine the correlation between the QOL and the severity of acne, in Lomé (Togo).

Method: From July 2017 to February 2018, we conducted a study in three dermatology departments of Lomé. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-018-0075-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106930PMC
August 2018
10 Reads

Expert Consensus on The Management of Dermatophytosis in India (ECTODERM India).

BMC Dermatol 2018 07 24;18(1). Epub 2018 Jul 24.

Department of Dermatology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Background: Dermatophytosis management has become an important public health issue, with a large void in research in the area of disease pathophysiology and management. Current treatment recommendations appear to lose their relevance in the current clinical scenario. The objective of the current consensus was to provide an experience-driven approach regarding the diagnosis and management of tinea corporis, cruris and pedis. Read More

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http://dx.doi.org/10.1186/s12895-018-0073-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057051PMC
July 2018
15 Reads

Persistence rates and medical costs of biological therapies for psoriasis treatment in Japan: a real-world data study using a claims database.

BMC Dermatol 2018 07 11;18(1). Epub 2018 Jul 11.

Health Economics and Outcomes Research, Janssen-Cilag GmbH, Johnson & Johnson Platz 1, Neuss, 41470, Germany.

Background: Biological therapies (BTs) including infliximab (IFX), adalimumab (ADL), secukinumab (SCK) and ustekinumab (UST) are approved in Japan for the treatment of psoriasis. Although the persistence rates and medical costs of BTs treatment have been investigated in multiple foreign studies in recent years, few such studies have been conducted in Japan and the differences between patients who adhered to treatment and those who did not have not been reported. This study is aimed at investigating the persistence rates and medical costs of BTs in the treatment of psoriasis in Japan, using the real-world data from a large-scale claims database. Read More

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http://dx.doi.org/10.1186/s12895-018-0074-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042444PMC
July 2018
5 Reads

Real-world health outcomes in adults with moderate-to-severe psoriasis in the United States: a population study using electronic health records to examine patient-perceived treatment effectiveness, medication use, and healthcare resource utilization.

BMC Dermatol 2018 06 28;18(1). Epub 2018 Jun 28.

Eli Lilly and Company, Indianapolis, IN, USA.

Background: Little is known regarding real-world health outcomes data among US psoriasis patients, but electronic health records (EHR) that collect structured data at point-of-care may provide opportunities to investigate real-world health outcomes among psoriasis patients. Our objective was to investigate patient-perceived treatment effectiveness, patterns of medication use (duration, switching, and/or discontinuation), healthcare resource utilization, and medication costs using real-world data from psoriasis patients.

Methods: Data for adults (≥18-years) with a dermatology provider-given diagnosis of psoriasis from 9/2014-9/2015 were obtained from dermatology practices using a widely used US dermatology-specific EHR containing over 500,000 psoriasis patients. Read More

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http://dx.doi.org/10.1186/s12895-018-0072-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025830PMC
June 2018
8 Reads

Can an app supporting psoriasis patients improve adherence to topical treatment? A single-blind randomized controlled trial.

BMC Dermatol 2018 02 7;18(1). Epub 2018 Feb 7.

Department of Dermatology and Allergy Centre, Odense University Hospital, Kløvervænget 15, 5000, Odense C, Denmark.

Background: Topical corticosteroid or corticosteroid/calcipotriol preparations are recommended first-line topical treatments of psoriasis, but a main cause for the lack of efficacy of topical treatments is considered low rates of adherence to topical drugs. Patient support by the use of applications (apps) for smartphones is suggested to improve medical adherence.

Methods/design: Design: An investigator-initiated, single-center, single-blind, parallel-group, phase-4 clinical superiority randomized controlled trial (RCT). Read More

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http://dx.doi.org/10.1186/s12895-018-0071-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804085PMC
February 2018
4 Reads

Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach.

BMC Dermatol 2018 02 7;18(1). Epub 2018 Feb 7.

LABS, Persistent Systems Limited, 9A/12, Erandwane, Pune, Maharashtra, 411004, India.

Background: Topical Betamethasone (BM) and Pimecrolimus (PC) are widely used drugs in the treatment of atopic dermatitis (AD). Though the biomolecules and biological pathways affected by the drugs are known, the causal inter-relationships among these pathways in the context of skin is not available. We aim to derive this insight by using transcriptomic data of AD skin samples treated with BM and PC using systems biology approach. Read More

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http://dx.doi.org/10.1186/s12895-018-0070-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803917PMC
February 2018
5 Reads

A novel PLEC nonsense homozygous mutation (c.7159G > T; p.Glu2387*) causes epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia: a case report.

BMC Dermatol 2018 01 20;18(1). Epub 2018 Jan 20.

Molecular Genetics and Pathology Unit, Hospital of Divino Espírito Santo of Ponta Delgada, EPER, Av. D. Manuel I, 9500-370, Ponta Delgada, São Miguel Island, Azores, Portugal.

Background: Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD; OMIM #226670) is an autosomal recessive disease, characterized mainly by skin blistering at birth or shortly thereafter, progressive muscle weakness, and rarely by alopecia. EBS-MD is caused by mutations in the PLEC gene (OMIM *601282), which encodes plectin, a structural protein expressed in several tissues, including epithelia and muscle. We describe a patient affected with EBS-MD and diffuse alopecia in which we identified a novel pathogenic mutation by PCR amplification of all coding exons and exon-intron boundaries of PLEC gene, followed by bidirectional Sanger sequencing. Read More

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http://dx.doi.org/10.1186/s12895-018-0069-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775598PMC
January 2018
13 Reads

A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction?

BMC Dermatol 2017 Dec 20;17(1):16. Epub 2017 Dec 20.

Clinical and Experimental Allergy and Immunology Laboratory LIM-56, University of São Paulo Medical School, São Paulo, Brazil.

Background: Erythroderma is characterized by erythema and scaling affecting more than 90% of the body surface area. Inflammatory, neoplastic and, more rarely, infectious diseases may culminate with erythroderma. Diagnosis of the underlying disorder is therefore crucial to institute the appropriate therapy. Read More

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http://dx.doi.org/10.1186/s12895-017-0068-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738805PMC
December 2017
14 Reads

Composite hemangioendothelioma of the forehead and right eye; a case report.

BMC Dermatol 2017 12 12;17(1):15. Epub 2017 Dec 12.

Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Hemangioendothelioma includes several types of vascular neoplasms , as well as both benign and malignant growth.

Case Presentation: This study evaluated a case of a 78-year-old female diagnosed with composite hemangioendothelioma (CHE). This patient had an 18-month history of painless inflammatory lesions and erythema on the left forehead and right upper eyelid. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-017-0067-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727897PMC
December 2017
10 Reads

Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: a pilot study.

BMC Dermatol 2017 11 28;17(1):14. Epub 2017 Nov 28.

Unesp Medical School, Botucatu, SP, Brazil.

Background: Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening is not known. This study aimed to investigate clinical and histologic alterations promoted by skin microneedling in facial melasma. Read More

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http://dx.doi.org/10.1186/s12895-017-0066-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706369PMC
November 2017
7 Reads

BAP1: case report and insight into a novel tumor suppressor.

BMC Dermatol 2017 Nov 22;17(1):13. Epub 2017 Nov 22.

Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104, USA.

Background: BRCA1-Associated-Protein 1 (BAP1) is a dynamic tumor suppressor which, when mutated, has been associated with an increased risk of uveal melanoma, cutaneous melanoma, mesothelioma, and several other cancers. Germline BAP1 mutations have been extensively studied, where they have been found to cause hereditary cancer susceptibility. However, their sporadic counterparts, tumors that display a loss of BAP1 expression due to somatically arising mutations in the BAP1 gene, remain a poorly described entity. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-017-0065-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700555PMC
November 2017
93 Reads

Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face - protocol of a multicenter, prospective, randomized, controlled, two-armed study.

BMC Dermatol 2017 10 25;17(1):12. Epub 2017 Oct 25.

Department of Dermatology, University Hospital Regensburg, 93042, Regensburg, Germany.

Background: Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated.

Methods/design: In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery. In the DL-PDT group (experimental group), 5 treatments of the entire face are conducted over the course of 18 months. Read More

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http://bmcdermatol.biomedcentral.com/articles/10.1186/s12895
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http://dx.doi.org/10.1186/s12895-017-0064-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657041PMC
October 2017
8 Reads

Rationale and Design of the Brigham Cohort for psoriasis and psoriatic arthritis registry (COPPAR).

BMC Dermatol 2017 08 16;17(1):11. Epub 2017 Aug 16.

Division of Rheumatology, Department of Medicine of the Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Background: Psoriasis (PsO) and psoriatic arthritis (PsA) are related conditions with poorly defined transition among them, risk factors for progression, complex treatment algorithms, and biomarkers for treatment response and long-term outcomes. We describe the development of a PsO/PsA registry at an academic medical center.

Methods: We developed a single-center PsO/PsA longitudinal disease registry including biorepository that captures relevant disease markers and treatment choices in a circumscribed population with a defined catchment area. Read More

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http://dx.doi.org/10.1186/s12895-017-0063-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559864PMC
August 2017
16 Reads

Prevalence of head lice infestation and pediculicidal effect of permethrine shampoo in primary school girls in a low-income area in southeast of Iran.

BMC Dermatol 2017 07 24;17(1):10. Epub 2017 Jul 24.

Department of Medical Entomology and Vector Control, Faculty of Health, Hormozgan University of Medical Sciences, P.O. Box: 79145-3838, Bandar Abbas, Iran.

Background: Head lice infestation is a common public health problem that is most prevalent in primary school children throughout the world, especially in developing countries including different parts of Iran. This study aimed to determine the prevalence and risk factors associated with head lice infestation and pediculicidal effect of 1% permethrin shampoo in primary schools girls of Bashagard County, one of the low socioeconomic areas in southeast of Iran.

Methods: In this interventional study six villages with similar demographical situations were selected and randomly assigned into intervention and control areas. Read More

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http://bmcdermatol.biomedcentral.com/articles/10.1186/s12895
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http://dx.doi.org/10.1186/s12895-017-0062-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525205PMC
July 2017
10 Reads

Variation of mutant allele frequency in NRAS Q61 mutated melanomas.

BMC Dermatol 2017 07 1;17(1). Epub 2017 Jul 1.

Research Unit EA4340 Biomarkers in Cancerology and Hemato Oncology, Versailles SQY University, Paris-Saclay University, 9, Avenue Charles de Gaulle, 92104, Boulogne-Billancourt, France.

Background: Somatic mutations of BRAF or NRAS activating the MAP kinase cell signaling pathway are present in 70% of cutaneous melanomas. The mutant allele frequency of BRAF V600E (M%BRAF) was recently shown to be highly heterogeneous in melanomas. The present study focuses on the NRAS Q61 mutant allele frequency (M%NRAS). Read More

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http://dx.doi.org/10.1186/s12895-017-0061-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494128PMC
July 2017
10 Reads

SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes.

BMC Dermatol 2017 06 10;17(1). Epub 2017 Jun 10.

School of Medical Science, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.

Background: Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB plus heat exposed keratinocytes. Read More

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http://dx.doi.org/10.1186/s12895-017-0060-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466784PMC
June 2017
8 Reads

Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report.

BMC Dermatol 2017 05 18;17(1). Epub 2017 May 18.

Department of Dermatology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Koch CRB II, Unit 206, Baltimore, MD, 21231, USA.

Background: Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on the acquired form that presents in adulthood. Unlike its inherited counterpart, acquired AE (AAE) is often secondary to underlying pathologic or iatrogenic etiologies that interfere with nutritional absorption, such as inflammatory bowel disease or alcoholism. Read More

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http://dx.doi.org/10.1186/s12895-017-0059-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437591PMC
May 2017
36 Reads

Tight controlled dose reduction of biologics in psoriasis patients with low disease activity: a randomized pragmatic non-inferiority trial.

BMC Dermatol 2017 05 8;17(1). Epub 2017 May 8.

Department of Dermatology, Radboud University Medical Center, Rene Descartesdreef 1, 6525 GL, Nijmegen, The Netherlands.

Background: Psoriasis is an immune-mediated chronic inflammatory skin disorder for which several targeted biologic therapies became available in the last 10 years. Data from patients with rheumatoid arthritis revealed that dose tapering combined with tight control of disease activity is successful. For psoriasis patients the lowest effective dose of biologics needs to be determined. Read More

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http://dx.doi.org/10.1186/s12895-017-0057-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422943PMC
May 2017
34 Reads

Evaluation of therapeutic potential of VB-001, a leave-on formulation, for the treatment of moderate adherent dandruff.

BMC Dermatol 2017 05 3;17(1). Epub 2017 May 3.

Medicine & HST, Brigham and Women's Hospital, Harvard Medical School, Room 317, 65 Landsdowne Street, Cambridge, MA, 02139, USA.

Background: Dandruff is a common scalp condition characterized by excessive scaling and itch. Aberrant colonization of the scalp by commensal Malassezia spp. is a major contributor in the multifactorial etiology of dandruff. Read More

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http://dx.doi.org/10.1186/s12895-017-0058-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415814PMC
May 2017
11 Reads

A prospective analysis of pinch grafting of chronic leg ulcers in a series of elderly patients in rural Cameroon.

BMC Dermatol 2017 03 20;17(1). Epub 2017 Mar 20.

Department of Surgery and Obstetrics/Gynaecology, Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Background: Chronic leg ulcers (CLUs) pose serious public health concerns worldwide. They mainly affect the elderly population. Pinch grafting (PG) could be used to treat a variety of CLUs. Read More

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http://dx.doi.org/10.1186/s12895-017-0056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360079PMC
March 2017
21 Reads

Expression profiling and bioinformatic analyses suggest new target genes and pathways for human hair follicle related microRNAs.

BMC Dermatol 2017 02 22;17(1). Epub 2017 Feb 22.

Institute of Human Genetics, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

Background: Human hair follicle (HF) cycling is characterised by the tight orchestration and regulation of signalling cascades. Research shows that micro(mi)RNAs are potent regulators of these pathways. However, knowledge of the expression of miRNAs and their target genes and pathways in the human HF is limited. Read More

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http://dx.doi.org/10.1186/s12895-017-0054-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322611PMC
February 2017
9 Reads

Skin cancer knowledge and attitudes in the region of Fez, Morocco: a cross-sectional study.

BMC Dermatol 2017 02 17;17(1). Epub 2017 Feb 17.

Department of dermatology, University Hospital Hassan II, 202 Hay Mohamadi, Fez, Morocco.

Background: The prevalence of skin cancers is constantly increasing in Morocco, and they have gradually become more aggressive due to a significant delay in the diagnosis. Our aim was to assess the levels of awareness and the influencing factors related to skin cancer knowledge in Morocco.

Methods: This cross-sectional study was carried out in Morocco through the medium of a validated questionnaire, which contained several items - demographics, skin cancer knowledge and attitudes towards skin cancer patients- during a period of 1 year (2014). Read More

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http://dx.doi.org/10.1186/s12895-017-0055-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316218PMC
February 2017
14 Reads

Knowledge, attitudes and practices of the medical personnel regarding atopic dermatitis in Yaoundé, Cameroon.

BMC Dermatol 2017 02 16;17(1). Epub 2017 Feb 16.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box: 8314, Yaoundé, Cameroon.

Background: Atopic dermatitis (AD) is a chronic, relapsing and pruritic inflammatory skin disease whose management remains unclear to most non-dermatologists. This study aimed to assess the knowledge, attitudes and practices (KAP) of the medical staff regarding AD in Yaoundé, Cameroon.

Methods: This was a cross-sectional study conducted from January to April 2014 in 20 health facilities located in Yaoundé, the capital city of Cameroon. Read More

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http://dx.doi.org/10.1186/s12895-017-0053-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314472PMC
February 2017
21 Reads

Treatment of plaque psoriasis with an ointment formulation of the Janus kinase inhibitor, tofacitinib: a Phase 2b randomized clinical trial.

BMC Dermatol 2016 10 3;16(1):15. Epub 2016 Oct 3.

Pfizer Worldwide Biopharmaceuticals, Global Innovative Pharma Business, Groton, CT, USA.

Background: Most psoriasis patients have mild to moderate disease, commonly treated topically. Current topical agents have limited efficacy and undesirable side effects associated with long-term use. Tofacitinib is a small molecule Janus kinase inhibitor investigated for the topical treatment of psoriasis. Read More

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http://dx.doi.org/10.1186/s12895-016-0051-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048458PMC
October 2016
40 Reads

Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report.

BMC Dermatol 2016 09 20;16(1):14. Epub 2016 Sep 20.

Cancer Treatment and Research Center, Mail Code 7876, 7979 Wurzbach Road, San Antonio, TX, 78229-4427, USA.

Background: Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Chronic cutaneous lupus erythematosus (CCLE) is an autoimmune disease that is associated with autoantibody production and T-cell dysfunction. Cutaneous manifestations of sarcoidosis may mimic CCLE and vice versa making it difficult to reach a diagnosis clinically. Read More

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http://bmcdermatol.biomedcentral.com/articles/10.1186/s12895
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http://dx.doi.org/10.1186/s12895-016-0052-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028922PMC
September 2016
9 Reads

Risk factors of keloids in Syrians.

BMC Dermatol 2016 09 20;16(1):13. Epub 2016 Sep 20.

Department of Plastic and Reconstructive Surgery, Tishreen University, Lattakia, Syria.

Background: Keloid is a benign fibrous growth, which presents in scar tissue of predisposed individuals. It is a result of irregular wound healing, but the exact mechanism is unknown. However, several factors may play a role in keloid formation. Read More

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http://dx.doi.org/10.1186/s12895-016-0050-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028955PMC
September 2016
9 Reads

Randomized placebo control study of insulin sensitizers (Metformin and Pioglitazone) in psoriasis patients with metabolic syndrome (Topical Treatment Cohort).

BMC Dermatol 2016 08 17;16(1):12. Epub 2016 Aug 17.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

Background: Increased prevalence of metabolic syndrome (MS) is observed in psoriasis. Metformin has shown improvement in cardiovascular risk factors while pioglitazone demonstrated anti proliferative, anti-inflammatory and anti angiogenic effects. Study objective is to evaluate the efficacy and safety of Insulin sensitizers (metformin and pioglitazone) in psoriasis patients with metabolic syndrome (MS). Read More

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http://dx.doi.org/10.1186/s12895-016-0049-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987981PMC
August 2016
23 Reads

A multicenter, randomized, open-label pilot trial assessing the efficacy and safety of etanercept 50 mg twice weekly followed by etanercept 25 mg twice weekly, the combination of etanercept 25 mg twice weekly and acitretin, and acitretin alone in patients with moderate to severe psoriasis.

BMC Dermatol 2016 07 25;16(1):11. Epub 2016 Jul 25.

Pfizer Pharmaceuticals Korea Limited, Seoul, Korea.

Background: Etanercept, a soluble tumor necrosis factor receptor, and acitretin have been shown to be effective in treating psoriasis. Acitretin is widely used in Korea. However, the combination of etanercept plus acitretin has not been evaluated among Korean patients with psoriasis. Read More

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http://dx.doi.org/10.1186/s12895-016-0048-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960797PMC
July 2016
25 Reads

Patch testing in Iranian children with allergic contact dermatitis.

BMC Dermatol 2016 07 12;16(1):10. Epub 2016 Jul 12.

Sharif University of Technology, Tehran, Iran.

Background: Allergic contact dermatitis is a common disorder in adults and children alike and appears to be on the increase. The purpose of this study was to determine the sensitization trends in Iranian children with contact dermatitis.

Methods: The result of 109 patch tests performed using the 24 allergens of the European Standard Series in patients below 18 years old from September 2007 to March 2009 were recorded and analyzed. Read More

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http://dx.doi.org/10.1186/s12895-016-0047-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943022PMC
July 2016
12 Reads

Effect of 12-O-tetradecanoylphorbol-13-acetate-induced psoriasis-like skin lesions on systemic inflammation and atherosclerosis in hypercholesterolaemic apolipoprotein E deficient mice.

BMC Dermatol 2016 07 11;16(1). Epub 2016 Jul 11.

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Risk of cardiovascular disease is increased in patients with psoriasis, but molecular mechanisms linking the two conditions have not been clearly established. Lack of appropriate animal models has hampered generation of new knowledge in this area of research and we therefore sought to develop an animal model with combined atherosclerosis and psoriasis-like skin inflammation.

Methods: Topical 12-O-tetradecanoylphorbol-13-acetate (TPA) was applied to the ears twice per week for 8 weeks in atherosclerosis-prone apolipoprotein E deficient (ApoE(-/-)) mice. Read More

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http://dx.doi.org/10.1186/s12895-016-0046-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940745PMC
July 2016
20 Reads

Enzymatic debridement for the treatment of severely burned upper extremities - early single center experiences.

BMC Dermatol 2016 06 24;16(1). Epub 2016 Jun 24.

Department of Hand, Plastic and Reconstructive Surgery - Burn Center, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Strasse 13, 67071, Ludwigshafen, Germany.

Background: Severe burns of hands and arms are complex and challenging injuries. The Standard of care (SOC) - necrosectomy with skin grafting - is often associated with poor functional or aesthetic outcome. Enzymatic debridement (ED) is considered one promising alternative but, until recently, results proved to be highly variable. Read More

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http://dx.doi.org/10.1186/s12895-016-0045-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920996PMC
June 2016
17 Reads

The first Danish family reported with an AQP5 mutation presenting diffuse non-epidermolytic palmoplantar keratoderma of Bothnian type, hyperhidrosis and frequent Corynebacterium infections: a case report.

BMC Dermatol 2016 06 3;16(1). Epub 2016 Jun 3.

Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.

Background: An autosomal dominant form of diffuse non-epidermolytic palmoplantar keratoderma, palmoplantar keratoderma of Bothnian type, is caused by mutations in the AQP5 gene encoding the cell-membrane water channel protein aquaporin 5 leading to defective epidermal-water-barrier function in the epidermis of the palms and soles.

Case Presentation: We report the first Danish family diagnosed with diffuse non-epidermolytic palmoplantar keratoderma of Bothnian type in which fourteen individuals are potentially affected. The proband, a 36-year-old male had since childhood been affected by pronounced hyperhidrosis of the palms and soles along with palmoplantar keratoderma. Read More

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http://dx.doi.org/10.1186/s12895-016-0044-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891830PMC
June 2016
27 Reads

Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo.

BMC Dermatol 2016 05 26;16(1). Epub 2016 May 26.

School of Medical Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.

Background: UV radiation induces significant DNA damage in keratinocytes and is a known risk factor for skin carcinogenesis. However, it has been reported previously that repeated and simultaneous exposure to UV and heat stress increases the rate of cutaneous tumour formation in mice. Since constant exposure to high temperatures and UV are often experienced in the environment, the effects of exposure to UV and heat needs to be clearly addressed in human epidermal cells. Read More

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http://dx.doi.org/10.1186/s12895-016-0043-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882820PMC
May 2016
29 Reads

A case of erythrodermia from exacerbated psoriasis vulgaris due to treatment of acute hepatitis C.

BMC Dermatol 2016 05 26;16(1). Epub 2016 May 26.

Division of Infectious Diseases and Hospital Hygiene, Cantonal Hospital St.Gallen, Rorschacherstrasse 95, 9007, St.Gallen, Switzerland.

Background: Skin side effects during interferon-alpha and ribavirin treatment are common, but autoimmune dermatosis triggered by interferon-alpha is rare. We describe a case of erythrodermia from exacerbated psoriasis during the treatment of acute hepatitis C with pegylated-interferon-alpha and ribavirin. The incidence of psoriasis in this circumstance is unknown and only 36 cases are described in the literature, of which only one describes an erythrodermic psoriasis flare. Read More

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http://dx.doi.org/10.1186/s12895-016-0042-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881008PMC
May 2016
8 Reads

Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin.

BMC Dermatol 2016 05 20;16(1). Epub 2016 May 20.

Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, 43210, OH, USA.

Background: Nipple adenoma is a very uncommon, benign proliferative process of lactiferous ducts of the nipple. Clinically, it often presents as a palpable nipple nodule, a visible nipple skin erosive lesion, and/or with discharge from the surface of the nipple skin, and is primarily seen in middle-aged women. Resultantly, nipple adenoma can clinically mimic the presentation of mammary Paget's disease of the nipple. Read More

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http://dx.doi.org/10.1186/s12895-016-0041-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873987PMC
May 2016
22 Reads

Odonto-onycho-dermal dysplasia in a patient homozygous for a WNT10A nonsense mutation and mild manifestations of ectodermal dysplasia in carriers of the mutation.

BMC Dermatol 2016 Mar 10;16. Epub 2016 Mar 10.

Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Background: Odonto-onycho-dermal dysplasia (OODD) is a rare form of ectodermal dysplasia characterized by severe oligodontia, onychodysplasia, palmoplantar hyperkeratosis, dry skin, hypotrichosis, and hyperhidrosis of the palms and soles. The ectodermal dysplasias resulting from biallelic mutations in the WNT10A gene result in highly variable phenotypes, ranging from isolated tooth agenesis to OODD and Schöpf-Schulz-Passarge syndrome (SSPS).

Case Presentation: We identified a female patient, with consanguineous parents, who was clinically diagnosed with OODD. Read More

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http://dx.doi.org/10.1186/s12895-016-0040-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785680PMC
March 2016
32 Reads

Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool.

BMC Dermatol 2016 Jan 20;16. Epub 2016 Jan 20.

Department of Dermatology, Stanford University School of Medicine, 450 Broadway St., Redwood City, CA, 94063, USA.

Background: Estimates of an individual's cumulative ultraviolet (UV) radiation exposure can be useful since ultraviolet radiation exposure increases skin cancer risk, but a comprehensive tool that is practical for use in the clinic does not currently exist. The objective of this study is to develop a geographically-adjusted tool to systematically estimate an individual's self-reported cumulative UV radiation exposure, investigate the association of these estimates with skin cancer diagnosis, and assess test reliability.

Methods: A 12-item online questionnaire from validated survey items for UV exposure and skin cancer was administered to online volunteers across the United States and results cross-referenced with UV radiation indices. Read More

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http://www.biomedcentral.com/1471-5945/16/1
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http://dx.doi.org/10.1186/s12895-016-0038-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721109PMC
January 2016
23 Reads

Risk factors associated with abscess formation among patient with leg erysipelas (cellulitis) in sub-Saharan Africa: a multicenter study.

BMC Dermatol 2015 Dec 15;15:18. Epub 2015 Dec 15.

Service de dermato-vénéréologie, CHU Sylvanus Olympio, Université de Lomé, 08 BP 81056, Lomé 08, Togo.

Background: Abscess formation is a frequent local complication of leg erysipelas. In this study we aimed at identifying factors associated with abscess formation of leg erysipelas in patients in sub-Saharan African countries.

Method: This is a multicenter prospective study conducted in dermatology units in eight sub-Saharan African countries from October 2013 to September 2014. Read More

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http://dx.doi.org/10.1186/s12895-015-0037-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678644PMC
December 2015
29 Reads

Adherence to drug treatments and adjuvant barrier repair therapies are key factors for clinical improvement in mild to moderate acne: the ACTUO observational prospective multicenter cohort trial in 643 patients.

BMC Dermatol 2015 Sep 11;15:17. Epub 2015 Sep 11.

Isdin S.A. Medical Department, Provençals 33, Barcelona, Spain.

Background: In acne, several studies report a poor adherence to treatments. We evaluate, in a real-life setting conditions, the impact of compliance to physician's instructions, recommendations and adherence to the treatments on clinical outcome in patients with mild to moderate acne in an observational, non-interventional prospective study carried out in 72 Dermatologic Services in Spain (ACTUO Trial).

Methods: Six-hundred-forty-three subjects were enrolled and 566 patients (88 %) completed the 3 study visits. Read More

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http://dx.doi.org/10.1186/s12895-015-0036-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567797PMC
September 2015
13 Reads

Skin diseases in pediatric patients attending a tertiary dermatology hospital in Northern Tanzania: a cross-sectional study.

BMC Dermatol 2015 Sep 10;15:16. Epub 2015 Sep 10.

Department of Dermatology, Regional Dermatology Training Center, P.O. Box 8332, Moshi, Tanzania.

Background: Skin diseases affect 21-87 % of children in developing countries in Africa. However, the spectrum of the skin diseases varies from region to region due to several factors such as genetics, socioeconomic and environmental. The aim of this study was to determine the spectrum of childhood skin diseases in Tanzania. Read More

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http://dx.doi.org/10.1186/s12895-015-0035-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566193PMC
September 2015
8 Reads