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    223 results match your criteria BMC Dermatology[Journal]

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    Can an app supporting psoriasis patients improve adherence to topical treatment? A single-blind randomized controlled trial.
    BMC Dermatol 2018 Feb 7;18(1). Epub 2018 Feb 7.
    Department of Dermatology and Allergy Centre, Odense University Hospital, Kløvervænget 15, 5000, Odense C, Denmark.
    Background: Topical corticosteroid or corticosteroid/calcipotriol preparations are recommended first-line topical treatments of psoriasis, but a main cause for the lack of efficacy of topical treatments is considered low rates of adherence to topical drugs. Patient support by the use of applications (apps) for smartphones is suggested to improve medical adherence.

    Methods/design: Design: An investigator-initiated, single-center, single-blind, parallel-group, phase-4 clinical superiority randomized controlled trial (RCT). Read More

    Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach.
    BMC Dermatol 2018 Feb 7;18(1). Epub 2018 Feb 7.
    LABS, Persistent Systems Limited, 9A/12, Erandwane, Pune, Maharashtra, 411004, India.
    Background: Topical Betamethasone (BM) and Pimecrolimus (PC) are widely used drugs in the treatment of atopic dermatitis (AD). Though the biomolecules and biological pathways affected by the drugs are known, the causal inter-relationships among these pathways in the context of skin is not available. We aim to derive this insight by using transcriptomic data of AD skin samples treated with BM and PC using systems biology approach. Read More

    A novel PLEC nonsense homozygous mutation (c.7159G > T; p.Glu2387*) causes epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia: a case report.
    BMC Dermatol 2018 Jan 20;18(1). Epub 2018 Jan 20.
    Molecular Genetics and Pathology Unit, Hospital of Divino Espírito Santo of Ponta Delgada, EPER, Av. D. Manuel I, 9500-370, Ponta Delgada, São Miguel Island, Azores, Portugal.
    Background: Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD; OMIM #226670) is an autosomal recessive disease, characterized mainly by skin blistering at birth or shortly thereafter, progressive muscle weakness, and rarely by alopecia. EBS-MD is caused by mutations in the PLEC gene (OMIM *601282), which encodes plectin, a structural protein expressed in several tissues, including epithelia and muscle. We describe a patient affected with EBS-MD and diffuse alopecia in which we identified a novel pathogenic mutation by PCR amplification of all coding exons and exon-intron boundaries of PLEC gene, followed by bidirectional Sanger sequencing. Read More

    A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction?
    BMC Dermatol 2017 Dec 20;17(1):16. Epub 2017 Dec 20.
    Clinical and Experimental Allergy and Immunology Laboratory LIM-56, University of São Paulo Medical School, São Paulo, Brazil.
    Background: Erythroderma is characterized by erythema and scaling affecting more than 90% of the body surface area. Inflammatory, neoplastic and, more rarely, infectious diseases may culminate with erythroderma. Diagnosis of the underlying disorder is therefore crucial to institute the appropriate therapy. Read More

    Composite hemangioendothelioma of the forehead and right eye; a case report.
    BMC Dermatol 2017 Dec 12;17(1):15. Epub 2017 Dec 12.
    Tabriz University of Medical Sciences, Tabriz, Iran.
    Background: Hemangioendothelioma includes several types of vascular neoplasms , as well as both benign and malignant growth.

    Case Presentation: This study evaluated a case of a 78-year-old female diagnosed with composite hemangioendothelioma (CHE). This patient had an 18-month history of painless inflammatory lesions and erythema on the left forehead and right upper eyelid. Read More

    Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: a pilot study.
    BMC Dermatol 2017 Nov 28;17(1):14. Epub 2017 Nov 28.
    Unesp Medical School, Botucatu, SP, Brazil.
    Background: Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening is not known. This study aimed to investigate clinical and histologic alterations promoted by skin microneedling in facial melasma. Read More

    BAP1: case report and insight into a novel tumor suppressor.
    BMC Dermatol 2017 Nov 22;17(1):13. Epub 2017 Nov 22.
    Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104, USA.
    Background: BRCA1-Associated-Protein 1 (BAP1) is a dynamic tumor suppressor which, when mutated, has been associated with an increased risk of uveal melanoma, cutaneous melanoma, mesothelioma, and several other cancers. Germline BAP1 mutations have been extensively studied, where they have been found to cause hereditary cancer susceptibility. However, their sporadic counterparts, tumors that display a loss of BAP1 expression due to somatically arising mutations in the BAP1 gene, remain a poorly described entity. Read More

    Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face - protocol of a multicenter, prospective, randomized, controlled, two-armed study.
    BMC Dermatol 2017 Oct 25;17(1):12. Epub 2017 Oct 25.
    Department of Dermatology, University Hospital Regensburg, 93042, Regensburg, Germany.
    Background: Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated.

    Methods/design: In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery. In the DL-PDT group (experimental group), 5 treatments of the entire face are conducted over the course of 18 months. Read More

    Rationale and Design of the Brigham Cohort for psoriasis and psoriatic arthritis registry (COPPAR).
    BMC Dermatol 2017 Aug 16;17(1):11. Epub 2017 Aug 16.
    Division of Rheumatology, Department of Medicine of the Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
    Background: Psoriasis (PsO) and psoriatic arthritis (PsA) are related conditions with poorly defined transition among them, risk factors for progression, complex treatment algorithms, and biomarkers for treatment response and long-term outcomes. We describe the development of a PsO/PsA registry at an academic medical center.

    Methods: We developed a single-center PsO/PsA longitudinal disease registry including biorepository that captures relevant disease markers and treatment choices in a circumscribed population with a defined catchment area. Read More

    Prevalence of head lice infestation and pediculicidal effect of permethrine shampoo in primary school girls in a low-income area in southeast of Iran.
    BMC Dermatol 2017 Jul 24;17(1):10. Epub 2017 Jul 24.
    Department of Medical Entomology and Vector Control, Faculty of Health, Hormozgan University of Medical Sciences, P.O. Box: 79145-3838, Bandar Abbas, Iran.
    Background: Head lice infestation is a common public health problem that is most prevalent in primary school children throughout the world, especially in developing countries including different parts of Iran. This study aimed to determine the prevalence and risk factors associated with head lice infestation and pediculicidal effect of 1% permethrin shampoo in primary schools girls of Bashagard County, one of the low socioeconomic areas in southeast of Iran.

    Methods: In this interventional study six villages with similar demographical situations were selected and randomly assigned into intervention and control areas. Read More

    Variation of mutant allele frequency in NRAS Q61 mutated melanomas.
    BMC Dermatol 2017 Jul 1;17(1). Epub 2017 Jul 1.
    Research Unit EA4340 Biomarkers in Cancerology and Hemato Oncology, Versailles SQY University, Paris-Saclay University, 9, Avenue Charles de Gaulle, 92104, Boulogne-Billancourt, France.
    Background: Somatic mutations of BRAF or NRAS activating the MAP kinase cell signaling pathway are present in 70% of cutaneous melanomas. The mutant allele frequency of BRAF V600E (M%BRAF) was recently shown to be highly heterogeneous in melanomas. The present study focuses on the NRAS Q61 mutant allele frequency (M%NRAS). Read More

    SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes.
    BMC Dermatol 2017 Jun 10;17(1). Epub 2017 Jun 10.
    School of Medical Science, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.
    Background: Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB plus heat exposed keratinocytes. Read More

    Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report.
    BMC Dermatol 2017 May 18;17(1). Epub 2017 May 18.
    Department of Dermatology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Koch CRB II, Unit 206, Baltimore, MD, 21231, USA.
    Background: Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on the acquired form that presents in adulthood. Unlike its inherited counterpart, acquired AE (AAE) is often secondary to underlying pathologic or iatrogenic etiologies that interfere with nutritional absorption, such as inflammatory bowel disease or alcoholism. Read More

    Tight controlled dose reduction of biologics in psoriasis patients with low disease activity: a randomized pragmatic non-inferiority trial.
    BMC Dermatol 2017 May 8;17(1). Epub 2017 May 8.
    Department of Dermatology, Radboud University Medical Center, Rene Descartesdreef 1, 6525 GL, Nijmegen, The Netherlands.
    Background: Psoriasis is an immune-mediated chronic inflammatory skin disorder for which several targeted biologic therapies became available in the last 10 years. Data from patients with rheumatoid arthritis revealed that dose tapering combined with tight control of disease activity is successful. For psoriasis patients the lowest effective dose of biologics needs to be determined. Read More

    Evaluation of therapeutic potential of VB-001, a leave-on formulation, for the treatment of moderate adherent dandruff.
    BMC Dermatol 2017 May 3;17(1). Epub 2017 May 3.
    Medicine & HST, Brigham and Women's Hospital, Harvard Medical School, Room 317, 65 Landsdowne Street, Cambridge, MA, 02139, USA.
    Background: Dandruff is a common scalp condition characterized by excessive scaling and itch. Aberrant colonization of the scalp by commensal Malassezia spp. is a major contributor in the multifactorial etiology of dandruff. Read More

    A prospective analysis of pinch grafting of chronic leg ulcers in a series of elderly patients in rural Cameroon.
    BMC Dermatol 2017 Mar 20;17(1). Epub 2017 Mar 20.
    Department of Surgery and Obstetrics/Gynaecology, Faculty of Health Sciences, University of Buea, Buea, Cameroon.
    Background: Chronic leg ulcers (CLUs) pose serious public health concerns worldwide. They mainly affect the elderly population. Pinch grafting (PG) could be used to treat a variety of CLUs. Read More

    Expression profiling and bioinformatic analyses suggest new target genes and pathways for human hair follicle related microRNAs.
    BMC Dermatol 2017 Feb 22;17(1). Epub 2017 Feb 22.
    Institute of Human Genetics, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
    Background: Human hair follicle (HF) cycling is characterised by the tight orchestration and regulation of signalling cascades. Research shows that micro(mi)RNAs are potent regulators of these pathways. However, knowledge of the expression of miRNAs and their target genes and pathways in the human HF is limited. Read More

    Skin cancer knowledge and attitudes in the region of Fez, Morocco: a cross-sectional study.
    BMC Dermatol 2017 Feb 17;17(1). Epub 2017 Feb 17.
    Department of dermatology, University Hospital Hassan II, 202 Hay Mohamadi, Fez, Morocco.
    Background: The prevalence of skin cancers is constantly increasing in Morocco, and they have gradually become more aggressive due to a significant delay in the diagnosis. Our aim was to assess the levels of awareness and the influencing factors related to skin cancer knowledge in Morocco.

    Methods: This cross-sectional study was carried out in Morocco through the medium of a validated questionnaire, which contained several items - demographics, skin cancer knowledge and attitudes towards skin cancer patients- during a period of 1 year (2014). Read More

    Knowledge, attitudes and practices of the medical personnel regarding atopic dermatitis in Yaoundé, Cameroon.
    BMC Dermatol 2017 Feb 16;17(1). Epub 2017 Feb 16.
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box: 8314, Yaoundé, Cameroon.
    Background: Atopic dermatitis (AD) is a chronic, relapsing and pruritic inflammatory skin disease whose management remains unclear to most non-dermatologists. This study aimed to assess the knowledge, attitudes and practices (KAP) of the medical staff regarding AD in Yaoundé, Cameroon.

    Methods: This was a cross-sectional study conducted from January to April 2014 in 20 health facilities located in Yaoundé, the capital city of Cameroon. Read More

    Treatment of plaque psoriasis with an ointment formulation of the Janus kinase inhibitor, tofacitinib: a Phase 2b randomized clinical trial.
    BMC Dermatol 2016 10 3;16(1):15. Epub 2016 Oct 3.
    Pfizer Worldwide Biopharmaceuticals, Global Innovative Pharma Business, Groton, CT, USA.
    Background: Most psoriasis patients have mild to moderate disease, commonly treated topically. Current topical agents have limited efficacy and undesirable side effects associated with long-term use. Tofacitinib is a small molecule Janus kinase inhibitor investigated for the topical treatment of psoriasis. Read More

    Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report.
    BMC Dermatol 2016 09 20;16(1):14. Epub 2016 Sep 20.
    Cancer Treatment and Research Center, Mail Code 7876, 7979 Wurzbach Road, San Antonio, TX, 78229-4427, USA.
    Background: Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Chronic cutaneous lupus erythematosus (CCLE) is an autoimmune disease that is associated with autoantibody production and T-cell dysfunction. Cutaneous manifestations of sarcoidosis may mimic CCLE and vice versa making it difficult to reach a diagnosis clinically. Read More

    Risk factors of keloids in Syrians.
    BMC Dermatol 2016 09 20;16(1):13. Epub 2016 Sep 20.
    Department of Plastic and Reconstructive Surgery, Tishreen University, Lattakia, Syria.
    Background: Keloid is a benign fibrous growth, which presents in scar tissue of predisposed individuals. It is a result of irregular wound healing, but the exact mechanism is unknown. However, several factors may play a role in keloid formation. Read More

    Randomized placebo control study of insulin sensitizers (Metformin and Pioglitazone) in psoriasis patients with metabolic syndrome (Topical Treatment Cohort).
    BMC Dermatol 2016 08 17;16(1):12. Epub 2016 Aug 17.
    Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
    Background: Increased prevalence of metabolic syndrome (MS) is observed in psoriasis. Metformin has shown improvement in cardiovascular risk factors while pioglitazone demonstrated anti proliferative, anti-inflammatory and anti angiogenic effects. Study objective is to evaluate the efficacy and safety of Insulin sensitizers (metformin and pioglitazone) in psoriasis patients with metabolic syndrome (MS). Read More

    A multicenter, randomized, open-label pilot trial assessing the efficacy and safety of etanercept 50 mg twice weekly followed by etanercept 25 mg twice weekly, the combination of etanercept 25 mg twice weekly and acitretin, and acitretin alone in patients with moderate to severe psoriasis.
    BMC Dermatol 2016 07 25;16(1):11. Epub 2016 Jul 25.
    Pfizer Pharmaceuticals Korea Limited, Seoul, Korea.
    Background: Etanercept, a soluble tumor necrosis factor receptor, and acitretin have been shown to be effective in treating psoriasis. Acitretin is widely used in Korea. However, the combination of etanercept plus acitretin has not been evaluated among Korean patients with psoriasis. Read More

    Patch testing in Iranian children with allergic contact dermatitis.
    BMC Dermatol 2016 07 12;16(1):10. Epub 2016 Jul 12.
    Sharif University of Technology, Tehran, Iran.
    Background: Allergic contact dermatitis is a common disorder in adults and children alike and appears to be on the increase. The purpose of this study was to determine the sensitization trends in Iranian children with contact dermatitis.

    Methods: The result of 109 patch tests performed using the 24 allergens of the European Standard Series in patients below 18 years old from September 2007 to March 2009 were recorded and analyzed. Read More

    Effect of 12-O-tetradecanoylphorbol-13-acetate-induced psoriasis-like skin lesions on systemic inflammation and atherosclerosis in hypercholesterolaemic apolipoprotein E deficient mice.
    BMC Dermatol 2016 07 11;16(1). Epub 2016 Jul 11.
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Background: Risk of cardiovascular disease is increased in patients with psoriasis, but molecular mechanisms linking the two conditions have not been clearly established. Lack of appropriate animal models has hampered generation of new knowledge in this area of research and we therefore sought to develop an animal model with combined atherosclerosis and psoriasis-like skin inflammation.

    Methods: Topical 12-O-tetradecanoylphorbol-13-acetate (TPA) was applied to the ears twice per week for 8 weeks in atherosclerosis-prone apolipoprotein E deficient (ApoE(-/-)) mice. Read More

    Enzymatic debridement for the treatment of severely burned upper extremities - early single center experiences.
    BMC Dermatol 2016 06 24;16(1). Epub 2016 Jun 24.
    Department of Hand, Plastic and Reconstructive Surgery - Burn Center, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Strasse 13, 67071, Ludwigshafen, Germany.
    Background: Severe burns of hands and arms are complex and challenging injuries. The Standard of care (SOC) - necrosectomy with skin grafting - is often associated with poor functional or aesthetic outcome. Enzymatic debridement (ED) is considered one promising alternative but, until recently, results proved to be highly variable. Read More

    The first Danish family reported with an AQP5 mutation presenting diffuse non-epidermolytic palmoplantar keratoderma of Bothnian type, hyperhidrosis and frequent Corynebacterium infections: a case report.
    BMC Dermatol 2016 06 3;16(1). Epub 2016 Jun 3.
    Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.
    Background: An autosomal dominant form of diffuse non-epidermolytic palmoplantar keratoderma, palmoplantar keratoderma of Bothnian type, is caused by mutations in the AQP5 gene encoding the cell-membrane water channel protein aquaporin 5 leading to defective epidermal-water-barrier function in the epidermis of the palms and soles.

    Case Presentation: We report the first Danish family diagnosed with diffuse non-epidermolytic palmoplantar keratoderma of Bothnian type in which fourteen individuals are potentially affected. The proband, a 36-year-old male had since childhood been affected by pronounced hyperhidrosis of the palms and soles along with palmoplantar keratoderma. Read More

    Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo.
    BMC Dermatol 2016 05 26;16(1). Epub 2016 May 26.
    School of Medical Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.
    Background: UV radiation induces significant DNA damage in keratinocytes and is a known risk factor for skin carcinogenesis. However, it has been reported previously that repeated and simultaneous exposure to UV and heat stress increases the rate of cutaneous tumour formation in mice. Since constant exposure to high temperatures and UV are often experienced in the environment, the effects of exposure to UV and heat needs to be clearly addressed in human epidermal cells. Read More

    A case of erythrodermia from exacerbated psoriasis vulgaris due to treatment of acute hepatitis C.
    BMC Dermatol 2016 05 26;16(1). Epub 2016 May 26.
    Division of Infectious Diseases and Hospital Hygiene, Cantonal Hospital St.Gallen, Rorschacherstrasse 95, 9007, St.Gallen, Switzerland.
    Background: Skin side effects during interferon-alpha and ribavirin treatment are common, but autoimmune dermatosis triggered by interferon-alpha is rare. We describe a case of erythrodermia from exacerbated psoriasis during the treatment of acute hepatitis C with pegylated-interferon-alpha and ribavirin. The incidence of psoriasis in this circumstance is unknown and only 36 cases are described in the literature, of which only one describes an erythrodermic psoriasis flare. Read More

    Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin.
    BMC Dermatol 2016 05 20;16(1). Epub 2016 May 20.
    Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, 43210, OH, USA.
    Background: Nipple adenoma is a very uncommon, benign proliferative process of lactiferous ducts of the nipple. Clinically, it often presents as a palpable nipple nodule, a visible nipple skin erosive lesion, and/or with discharge from the surface of the nipple skin, and is primarily seen in middle-aged women. Resultantly, nipple adenoma can clinically mimic the presentation of mammary Paget's disease of the nipple. Read More

    Odonto-onycho-dermal dysplasia in a patient homozygous for a WNT10A nonsense mutation and mild manifestations of ectodermal dysplasia in carriers of the mutation.
    BMC Dermatol 2016 Mar 10;16. Epub 2016 Mar 10.
    Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
    Background: Odonto-onycho-dermal dysplasia (OODD) is a rare form of ectodermal dysplasia characterized by severe oligodontia, onychodysplasia, palmoplantar hyperkeratosis, dry skin, hypotrichosis, and hyperhidrosis of the palms and soles. The ectodermal dysplasias resulting from biallelic mutations in the WNT10A gene result in highly variable phenotypes, ranging from isolated tooth agenesis to OODD and Schöpf-Schulz-Passarge syndrome (SSPS).

    Case Presentation: We identified a female patient, with consanguineous parents, who was clinically diagnosed with OODD. Read More

    Estimation of individual cumulative ultraviolet exposure using a geographically-adjusted, openly-accessible tool.
    BMC Dermatol 2016 Jan 20;16. Epub 2016 Jan 20.
    Department of Dermatology, Stanford University School of Medicine, 450 Broadway St., Redwood City, CA, 94063, USA.
    Background: Estimates of an individual's cumulative ultraviolet (UV) radiation exposure can be useful since ultraviolet radiation exposure increases skin cancer risk, but a comprehensive tool that is practical for use in the clinic does not currently exist. The objective of this study is to develop a geographically-adjusted tool to systematically estimate an individual's self-reported cumulative UV radiation exposure, investigate the association of these estimates with skin cancer diagnosis, and assess test reliability.

    Methods: A 12-item online questionnaire from validated survey items for UV exposure and skin cancer was administered to online volunteers across the United States and results cross-referenced with UV radiation indices. Read More

    Risk factors associated with abscess formation among patient with leg erysipelas (cellulitis) in sub-Saharan Africa: a multicenter study.
    BMC Dermatol 2015 Dec 15;15:18. Epub 2015 Dec 15.
    Service de dermato-vénéréologie, CHU Sylvanus Olympio, Université de Lomé, 08 BP 81056, Lomé 08, Togo.
    Background: Abscess formation is a frequent local complication of leg erysipelas. In this study we aimed at identifying factors associated with abscess formation of leg erysipelas in patients in sub-Saharan African countries.

    Method: This is a multicenter prospective study conducted in dermatology units in eight sub-Saharan African countries from October 2013 to September 2014. Read More

    Adherence to drug treatments and adjuvant barrier repair therapies are key factors for clinical improvement in mild to moderate acne: the ACTUO observational prospective multicenter cohort trial in 643 patients.
    BMC Dermatol 2015 Sep 11;15:17. Epub 2015 Sep 11.
    Isdin S.A. Medical Department, Provençals 33, Barcelona, Spain.
    Background: In acne, several studies report a poor adherence to treatments. We evaluate, in a real-life setting conditions, the impact of compliance to physician's instructions, recommendations and adherence to the treatments on clinical outcome in patients with mild to moderate acne in an observational, non-interventional prospective study carried out in 72 Dermatologic Services in Spain (ACTUO Trial).

    Methods: Six-hundred-forty-three subjects were enrolled and 566 patients (88 %) completed the 3 study visits. Read More

    Skin diseases in pediatric patients attending a tertiary dermatology hospital in Northern Tanzania: a cross-sectional study.
    BMC Dermatol 2015 Sep 10;15:16. Epub 2015 Sep 10.
    Department of Dermatology, Regional Dermatology Training Center, P.O. Box 8332, Moshi, Tanzania.
    Background: Skin diseases affect 21-87 % of children in developing countries in Africa. However, the spectrum of the skin diseases varies from region to region due to several factors such as genetics, socioeconomic and environmental. The aim of this study was to determine the spectrum of childhood skin diseases in Tanzania. Read More

    Magnitude and associated factors of Atopic dermatitis among children in Ayder referral hospital, Mekelle, Ethiopia.
    BMC Dermatol 2015 Aug 25;15:15. Epub 2015 Aug 25.
    Addis Ababa University, School of Public Health, Addis Ababa, Ethiopia.
    Background: Atopic Dermatitis (AD) is now a day's increasing in prevalence globally. A Prevalence of 5-25 % have been reported in different country. Even if its prevalence is known in most countries especially in developing countries there is scarcity with regard to prevalence and associated risk factors of AD among children in Ethiopia settings. Read More

    Role models in a preventive program for hand eczema among healthcare workers: a qualitative exploration of their main tasks and associated barriers and facilitators.
    BMC Dermatol 2015 Aug 20;15:14. Epub 2015 Aug 20.
    Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
    Background: Role models often play a role when implementing guidelines in healthcare. However, little is known about how role models perform their respective roles, or about which factors may hamper or enhance their functioning. The aim of the present study was therefore to investigate how role models perform there role as a part of a multifaceted implementation strategy on the prevention of hand eczema, and to identify barriers and facilitators for the performing of their role. Read More

    Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial.
    BMC Dermatol 2015 Aug 1;15:13. Epub 2015 Aug 1.
    Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Postboks 8905, MTFS, 7491, Trondheim, Norway.
    Background: Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic diseases is less certain. We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation. In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years. Read More

    Small lymphocytic lymphoma with florid perniosis-like features: a case report.
    BMC Dermatol 2015 Jul 23;15:11. Epub 2015 Jul 23.
    British Columbia Cancer Agency, 2410 Lee Avenue, Victoria, British Columbia, V8R 6 V5, Canada.
    Background: Small lymphocytic lymphoma is a relatively rare B-cell non-Hodgkin lymphoma that is considered to be the tissue equivalent of the much more common entity chronic lymphocytic leukemia. Cutaneous manifestations of small lymphocytic lymphoma are infrequent and the literature regarding them sparse. We describe here a case of a patient with a history of small lymphocytic lymphoma who developed perniosis-like features of the digits. Read More

    Features of human scabies in resource-limited settings: the Cameroon case.
    BMC Dermatol 2015 Jul 23;15:12. Epub 2015 Jul 23.
    Department of Medicine and Medical Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
    Background: The persistent high prevalence of human scabies, especially in low- and middle-income countries prompted us to research the sociodemographic profile of patients suffering from it, and its spreading factors in Cameroon, a resource-poor setting.

    Methods: We conducted a cross-sectional survey from October 2011 to September 2012 in three hospitals located in Yaoundé, Cameroon, and enrolled patients diagnosed with human scabies during dermatologists' consultations who volunteered to take part in the study.

    Results: We included 255 patients of whom 158 (62 %) were male. Read More

    Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers.
    BMC Dermatol 2015 Jul 14;15:10. Epub 2015 Jul 14.
    Reata Pharmaceuticals, Inc., 2801 Gateway Dr. Ste 150, Irving, TX, 75063, USA.
    Background: Topical application of the synthetic triterpenoid RTA 408 to rodents elicits a potent dermal cytoprotective phenotype through activation of the transcription factor Nrf2. Therefore, studies were conducted to investigate if such cytoprotective properties translate to human dermal cells, and a topical lotion formulation was developed and evaluated clinically.

    Methods: In vitro, RTA 408 (3-1000 nM) was incubated with primary human keratinocytes for 16 h. Read More

    Effect of etanercept therapy on psoriasis symptoms in patients from Latin America, Central Europe, and Asia: a subset analysis of the PRISTINE trial.
    BMC Dermatol 2015 May 21;15. Epub 2015 May 21.
    Global Innovative Pharma, Pfizer, New York, NY, USA.
    Background: Psoriasis prevalence and characteristics in Asia, Central Europe, and Latin America have not been thoroughly investigated and there are no large trials for biologic treatments for patients from these regions. The goal of this analysis was to report clinical response to anti-tumor necrosis factor-alpha treatment in these patients.

    Methods: Patients from Argentina, Czech Republic, Hungary, Mexico, Taiwan, and Thailand (N=171) were included in this subset analysis of the PRISTINE trial. Read More

    Effects of tofacitinib on lymphocyte sub-populations, CMV and EBV viral load in patients with plaque psoriasis.
    BMC Dermatol 2015 May 8;15. Epub 2015 May 8.
    Pfizer Inc, New York, NY, USA.
    Background: Plaque psoriasis is a debilitating skin condition that affects approximately 2% of the adult population and for which there is currently no cure. Tofacitinib is an oral Janus kinase inhibitor that is being investigated for psoriasis.

    Methods: The design of this study has been reported previously (NCT00678210). Read More

    Topical treatment with fresh human milk versus emollient on atopic eczema spots in young children: a small, randomized, split body, controlled, blinded pilot study.
    BMC Dermatol 2015 May 4;15. Epub 2015 May 4.
    Norwegian National Advisory Unit on Breastfeeding, Womens and Children´s Division, Oslo University Hospital, Oslo, Norway.
    Background: Public health nurses report on effects of fresh human milk as treatment for conjunctivitis, rhinitis and atopic eczema (AE), the latter being highly prevalent in early childhood. Emollients and topical corticosteroids are first line treatment of AE. As many caregivers have steroid phobia, alternative treatment options for mild AE are of interest. Read More

    Subjective stress reactivity in psoriasis - a cross sectional study of associated psychological traits.
    BMC Dermatol 2015 May 2;15. Epub 2015 May 2.
    Department of Dermatology and Venereology, University of Lund, Hudkliniken, Skåne University Hospital, Jan Waldenströmsg. 16, Malmö, 205 02, Sweden.
    Background: Stress or psychological distress is often described as a causative or maintaining factor in psoriasis. Psychological traits may influence the appraisal, interpretation and coping ability regarding stressful situations. Detailed investigations of psychological traits in relation to stress reactivity in psoriasis are rare. Read More

    Validation of the global resource of eczema trials (GREAT database).
    BMC Dermatol 2015 Mar 14;15. Epub 2015 Mar 14.
    Centre of Evidence Based Dermatology, School of Medicine, University of Nottingham, Nottingham, UK.
    Background: Eczema (syn. Atopic Eczema or Atopic Dermatitis) is a chronic, relapsing, itchy skin condition which probably results from a combination of genetic and environmental factors. The Global Resource of EczemA Trials (GREAT) is a collection of records of randomised controlled trials (RCTs) for eczema treatment produced from a highly sensitive search of six reference databases. Read More

    Photoallergic reaction in a patient receiving vandetanib for metastatic follicular thyroid carcinoma: a case report.
    BMC Dermatol 2015 Feb 13;15. Epub 2015 Feb 13.
    Department of Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 455, Houston, TX, 77030, USA.
    Background: Novel targeted agents have been increasingly developed and tested in clinical trials over the past 5-10 years, many with unknown and unanticipated side effects. We describe here a case of a patient with a history of metastatic follicular thyroid carcinoma that we believe developed vandetanib-associated photoallergic dermatitis while enrolled on a phase 1 clinical trial.

    Case Presentation: A 51-year-old Caucasian female with poorly differentiated, metastatic follicular thyroid carcinoma presented with a cutaneous eruption that developed over 3 to 4 days while treated on phase 1 clinical trial with vandetanib-based therapy. Read More

    Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients.
    BMC Dermatol 2015 Feb 12;15. Epub 2015 Feb 12.
    International Lyme and Associated Diseases Society, Bethesda, MD, USA.
    Background: Morgellons disease (MD) is a complex skin disorder characterized by ulcerating lesions that have protruding or embedded filaments. Many clinicians refer to this condition as delusional parasitosis or delusional infestation and consider the filaments to be introduced textile fibers. In contrast, recent studies indicate that MD is a true somatic illness associated with tickborne infection, that the filaments are keratin and collagen in composition and that they result from proliferation and activation of keratinocytes and fibroblasts in the skin. Read More

    Digital photography in skin cancer screening by mobile units in remote areas of Brazil.
    BMC Dermatol 2014 Dec 24;14:19. Epub 2014 Dec 24.
    Department of Cancer Prevention, Barretos Cancer Hospital, Rua Antenor Duarte Villella, 1331 - Bairro Dr. Paulo Prata, 14784-400, Barretos, SP, Brazil.
    Background: Non-melanoma skin cancer (NMSC) is one of the most common neoplasms in the world. Despite the low mortality rates, NMSC can still cause severe sequelae when diagnosed at advanced stages. Malignant melanoma, the third most common type of skin cancer, has more aggressive behavior and a worse prognosis. Read More

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