251 results match your criteria BMC Dermatology[Journal]


Epidemiology of psoriasis in hard-to-treat body locations: data from the Danish skin cohort.

BMC Dermatol 2020 May 20;20(1). Epub 2020 May 20.

Eli Lilly and Company, Indianapolis, Indiana, USA.

Background: Having psoriasis in hard-to-treat areas, i.e. the scalp, face, palms, soles, nails, and genitals, respectively, can impair patients' quality of life. Read More

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http://dx.doi.org/10.1186/s12895-020-00099-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238562PMC

Osteomyelitis complicating secondarily infected atopic eczema: two case reports and a narrative literature review.

BMC Dermatol 2020 02 3;20(1). Epub 2020 Feb 3.

Department of Dermatology, Nelson R Mandela School of Medicine, Private Bag X7, Congella, Durban, 4013, South Africa.

Background: Atopic eczema is a relapsing, itchy chronic cutaneous inflammatory disease that commonly affects children. The disease is often complicated by cutaneous infections such as eczema herpeticum, eczema vaccinatum and a varied number of bacterial infections - impetigo, cellulitis and erysipelas. However, rare case reports of infective endocarditis, otitis media and osteo-articular infections have been associated with atopic eczema. Read More

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http://dx.doi.org/10.1186/s12895-019-0098-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996158PMC
February 2020

Madurella mycetomatis infection of the foot: a case report of a neglected tropical disease in a non-endemic region.

BMC Dermatol 2020 01 10;20(1). Epub 2020 Jan 10.

Dermatology and Venereology Department, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.

Background: Mycetoma is an uncommon chronic granulomatous infection of cutaneous and subcutaneous tissues that can be caused by filamentous bacteria (actinomycetoma) or fungi (eumycetoma). It is the prerogative of young men between the third and fourth decade and is transmitted through any trauma causing an inoculating point. The classic clinical triad associates a painless hard and swelling subcutaneous mass, multiple fistulas, and the pathognomonic discharge of grains. Read More

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http://dx.doi.org/10.1186/s12895-019-0097-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953183PMC
January 2020

A rare case of Sweet syndrome secondary to melioidosis.

BMC Dermatol 2019 12 2;19(1):16. Epub 2019 Dec 2.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Melioidosis is an emerging infection in South Asia caused by Burkholderia pseudomallei with various clinical presentations that include pneumonia, bacteraemia, arthritis, and deep-seated abscesses. Various cutaneous manifestations have been described in association with melioidosis. However Sweet Syndrome secondary to melioidosis has not been reported in the literature. Read More

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http://dx.doi.org/10.1186/s12895-019-0096-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886164PMC
December 2019

Validation of the Atopic Dermatitis Control Tool (ADCT©) using a longitudinal survey of biologic-treated patients with atopic dermatitis.

BMC Dermatol 2019 11 6;19(1):15. Epub 2019 Nov 6.

Eastern Virginia Medical School, Norfolk, VA, USA.

Background: The Atopic Dermatitis Control Tool (ADCT©) is a brief patient self-administered instrument designed and validated to assess atopic dermatitis (AD) control; six AD symptoms and impacts are evaluated over the past week, including overall severity of symptoms, days with intense episodes of itching, intensity of bother, problem with sleep, impact on daily activities, and impact on mood or emotions. This study assessed the reliability, validity, and responsiveness of the ADCT in a longitudinal context, and provided thresholds to identify meaningful within-person change.

Methods: Data were from a prospective, longitudinal patient survey study of real-world effectiveness of dupilumab in patients with AD. Read More

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http://dx.doi.org/10.1186/s12895-019-0095-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833284PMC
November 2019

High efficacy of a dimeticone-based pediculicide following a brief application: in vitro assays and randomized controlled investigator-blinded clinical trial.

BMC Dermatol 2019 10 18;19(1):14. Epub 2019 Oct 18.

G. Pohl-Boskamp GmbH & Co. KG, Kieler Straße 11, 25551, Hohenlockstedt, Germany.

Background: Increasing resistance of head lice against neurotoxic agents and safety concerns have led to the search for treatment alternatives. Dimeticones with a physical mode of action are safe, and bear a reduced risk for the development of resistance.

Methods: We performed in vitro bioassays to assess pediculicidal and ovicidal activities of a new dimeticone-based product, and a randomized controlled clinical trial to assess efficacy, following 10 min application. Read More

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http://dx.doi.org/10.1186/s12895-019-0094-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806501PMC
October 2019

Comparative efficacy of three pediculicides to treat head lice infestation in primary school girls: a randomised controlled assessor blind trial in rural Iran.

BMC Dermatol 2019 09 12;19(1):13. Epub 2019 Sep 12.

Research Center for Health Sciences, Institute of Health, Department of Medical Entomology and Vector Control, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Head lice infestation (Pediculosis) is one of the most important health challenges particularly in primary school-aged children. It is often present among 6-11-year-old students in various tropical and temperate regions of the world. The aim of this study was to examine epidemiologic indices and comparative analysis of two pyrethroid-based and one non-chemical pediculicide products on head lice treatment of primary school girls in a rural setting of Fars province, south Iran, as part of a randomized controlled assessor blind trial. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-019-0093-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739928PMC
September 2019
1 Read

Ainhum, a rare mutilating dermatological disease in a female Cameroonian: a case report.

BMC Dermatol 2019 08 12;19(1):12. Epub 2019 Aug 12.

Health and Human Development (2HD) Research Network, Douala, Cameroon.

Background: Ainhum is an idiopathic dermatological disease characterized by a progressive constricting ring usually on the fifth toe, which may lead to spontaneous auto-amputation of the affected toe. Timely diagnosis and treatment are the key elements to avert amputations with resultant mutilating deformities, permanent handicaps and psychological sequelae. Though common in African descents, this pathology has not been described in the Cameroonian literature. Read More

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http://dx.doi.org/10.1186/s12895-019-0092-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689862PMC
August 2019
5 Reads

Gluteal hidradenitis suppurativa presenting pemphigus-like findings: case report.

BMC Dermatol 2019 07 23;19(1):11. Epub 2019 Jul 23.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Hidradenitis suppurativa is one member of the follicular occlusion triad: acne conglobata, hidradenitis suppurativa, and dissecting cellulitis of the scalp. The presence of acantholysis and desmoglein autoantibodies in hidradenitis suppurativa is rare.

Case Presentation: We report a case of 68-year-old male with a diagnosis of gluteal hidradenitis suppurativa co-presenting pemphigus-like findings including acantholysis and positive desmoglein autoantibodies. Read More

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http://dx.doi.org/10.1186/s12895-019-0091-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651910PMC
July 2019
4 Reads

A seven-year retrospective analysis of patch test data in a cohort of patients with contact dermatitis in Sri Lanka.

BMC Dermatol 2019 07 10;19(1):10. Epub 2019 Jul 10.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Patch testing with a baseline series is a common tool employed when the sensitizing agent in contact dermatitis is unclear. However, for Asian countries, there are no locally validated baseline series to utilize in screening.

Methods: We completed a retrospective analysis of all patients that had undergone patch testing with the European Baseline series, Shoe Series or Comprehensive International Baseline series, over 7 years from 2012 to 2018 in a tertiary care reference dermatology clinic in Sri Lanka to evaluate the suitability of these investigations to identify causes for contact dermatitis in the local study population. Read More

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http://dx.doi.org/10.1186/s12895-019-0090-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617664PMC
July 2019
2 Reads

Diaper dermatitis: a survey of risk factors in Thai children aged under 24 months.

BMC Dermatol 2019 07 2;19(1). Epub 2019 Jul 2.

Dermatology Division, Pediatric Department, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

Background: To identify the prevalence and risk factors associated with diaper dermatitis in Thai children aged 1-24 months.

Methods: This was a cross-sectional study of 1153 participants using structural questionnaires, which was conducted at Khon Kaen University Faculty of Medicine Pediatric department in Thailand. Univariate and multivariate logistic regression analyses were used to test the association between diaper dermatitis and its possible risk factors. Read More

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http://dx.doi.org/10.1186/s12895-019-0089-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604136PMC
July 2019
2 Reads

Rationale, objectives and design of PURE, a prospective registry of patients with moderate to severe chronic plaque psoriasis in Canada and Latin America.

BMC Dermatol 2019 06 21;19(1). Epub 2019 Jun 21.

Novartis Pharmaceuticals Canada Inc., Dorval, QC, Canada.

Background: Treatment options for the management of moderate to severe plaque psoriasis include phototherapy, oral systemic agents, and biologic therapy. Secukinumab, a fully human monoclonal antibody that selectively targets IL-17A, is the first IL-17 antagonist approved for this patient population. Long-term observational data are required for establishing the true population-based benefit-risk ratio of approved treatments. Read More

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http://dx.doi.org/10.1186/s12895-019-0087-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588885PMC
June 2019
21 Reads

A multi-item Physician Global Assessment scale to assess psoriasis disease severity: validation based on four phase III tofacitinib studies.

BMC Dermatol 2019 06 7;19(1). Epub 2019 Jun 7.

Pfizer Inc, 445 Eastern Point Road, Groton, CT, 06340, USA.

Background: Several different Physician Global Assessment (PGA) versions have been used in clinical studies as a co-primary end point to evaluate psoriasis severity. Tofacitinib is an oral Janus kinase inhibitor. We performed an analysis of the PGA using data from studies of tofacitinib in moderate to severe chronic plaque psoriasis. Read More

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http://dx.doi.org/10.1186/s12895-019-0088-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555979PMC
June 2019
16 Reads

Sofosbuvir induced leucocytoclasic vasculitis: a case report.

BMC Dermatol 2019 05 17;19(1). Epub 2019 May 17.

Department of Dermatology, University of Rome Tor Vergata, Viale Oxford, 81, 00133, Rome, Italy.

Background: We describe a case of leucocytoclasic vasculitis induced by Sofosbuvir and its disappearence after the end of the therapy. The hepatitis C virus, firstly described in 1989, is a major global health problem, with high morbidity and mortality. We observed a temporal relationship between the treatment and the onset of vasculitis. Read More

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http://dx.doi.org/10.1186/s12895-019-0086-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524249PMC
May 2019
2 Reads

Pattern of skin diseases in children attending a dermatology clinic in a referral hospital in Wolaita Sodo, southern Ethiopia.

BMC Dermatol 2019 04 8;19(1). Epub 2019 Apr 8.

College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Background: Epidemiological studies to determine the pattern of skin diseases among children are important for proper health care planning and management. The purpose of this study was to describe the pattern of skin diseases among pediatric patients seen at a dermatology outpatient clinic of Wolaita Sodo Teaching and Referral Hospital, southern Ethiopia.

Method: We conducted a retrospective hospital-based, cross-sectional study between January 2016 and December 2017 at a teaching and referral hospital dermatology outpatient department. Read More

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http://dx.doi.org/10.1186/s12895-019-0085-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454754PMC
April 2019
5 Reads

A novel elastin gene frameshift mutation in a Russian family with cutis laxa: a case report.

BMC Dermatol 2019 01 31;19(1). Epub 2019 Jan 31.

Pirogov Russian National Research Medical University, Ostrovitianova street 1, 117997, Moscow, Russia.

Background: Cutis laxa (CL) is a rare connective tissue disorder characterized by loose, redundant, inelastic and wrinkled skin. Patients develop a prematurely aged appearance. Inheritance can be autosomal dominant or autosomal recessive. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-019-0084-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357400PMC
January 2019
32 Reads

Mucous membrane pemphigoid-associated paronychia with onychomadesis.

BMC Dermatol 2019 01 23;19(1). Epub 2019 Jan 23.

Dermatology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease that is notoriously difficult to treat. Nail involvement in MMP is rare.

Case Presentation: We report on a 58 years old man with severe MMP who presented with onychomadesis. Read More

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http://dx.doi.org/10.1186/s12895-019-0083-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343326PMC
January 2019
12 Reads

Proderm technology: a water- based lipid delivery system for dermatitis that penetrates viable epidermis and has antibacterial effects.

BMC Dermatol 2019 01 22;19(1). Epub 2019 Jan 22.

Department of Dermatology, University of California San Francisco, San Francisco, California, USA.

Background: A defective skin barrier and bacterial colonization are two important factors in maintenance and progression of atopic dermatitis and chronic allergic/irritant hand dermatitis. A water-based lipid delivery system containing physiologic lipids was previously shown to be a useful adjunct in the treatment of hand dermatitis. We tested the ability of this formulation to penetrate into the viable epidermis and in addition assessed its antibacterial properties. Read More

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http://dx.doi.org/10.1186/s12895-019-0082-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343233PMC
January 2019
2 Reads

Differences in microRNA expression between melanoma and healthy adjacent skin.

BMC Dermatol 2019 01 5;19(1). Epub 2019 Jan 5.

Department of Pathophysiology, Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russia.

Background: The tumor microenvironment is composed of cancer-associated fibroblasts, tumor-associated macrophages, endothelial cells, immune cells, signaling molecules and extracellular matrix structures, which closelycommunicate with the tumor via multiple mechanisms. MicroRNAs are paracrine regulators that provide a direct interaction between the microenvironment and cancer cells. In the presentstudy, we aimed to identify the microRNA expression profile in melanoma compared with thatin healthy adjacent skin, with a further assessment of altered microRNA signaling pathways and target genes. Read More

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http://dx.doi.org/10.1186/s12895-018-0081-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321655PMC
January 2019
5 Reads

Interdisciplinary and multiprofessional outpatient secondary individual prevention of work-related skin diseases in the metalworking industry: 1-year follow-up of a patient cohort.

BMC Dermatol 2018 12 12;18(1):12. Epub 2018 Dec 12.

Department of Dermatology, Klinikum Dortmund gGmbH, Beurhausstr. 40, 44137, Dortmund, Germany.

Background: In Germany, work-related skin diseases are predominant within the spectrum of reported occupational diseases. Metal workers are among the high-risk professions. Offering effective prevention programs to affected patients is of utmost importance to avoid deterioration of the disease and job loss. Read More

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http://dx.doi.org/10.1186/s12895-018-0080-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292163PMC
December 2018
9 Reads

Assessing skin disease and associated health-related quality of life in a rural Lao community.

BMC Dermatol 2018 12 4;18(1):11. Epub 2018 Dec 4.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology laboratory, Mahosot Hospital, Vientiane, Laos.

Background: Skin diseases are common and often have an impact on an individual's health-related quality of life. In rural communities where access to healthcare may be limited and individuals rely on farming for food and income, the impact of skin diseases may be greater. The objectives for this study were to perform an assessment of skin disease prevalence in a rural village in Laos and assess the associated impact of any skin disease found using the Dermatology Life Quality Index (DLQI). Read More

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http://dx.doi.org/10.1186/s12895-018-0079-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278038PMC
December 2018
54 Reads

Exploratory study of the reproducibility of the SCore for INtrinsic and EXtrinsic skin aging (SCINEXA) scale in "Ruta Escondida de la Mitad del Mundo", Ecuador, 2017.

BMC Dermatol 2018 11 6;18(1):10. Epub 2018 Nov 6.

Ministry of Public Health, Quito, Ecuador.

Background: Few studies have been published related to the analysis of different skin aging parameters for whole-body skin using the SCINEXA scale for skin damage. The aim of this study was to evaluate the reproducibility of the SCINEXA scale (SCore for INtrinsic and EXtrinsic skin Aging) in South-Americans non-Caucasian population of a region of Ecuador.

Methods: Exploratory observational study. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-018-0078-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219042PMC
November 2018
31 Reads

Cost and effectiveness of prescribing emollient therapy for atopic eczema in UK primary care in children and adults: a large retrospective analysis of the Clinical Practice Research Datalink.

BMC Dermatol 2018 10 29;18(1). Epub 2018 Oct 29.

NHS Wakefield Clinical Commissioning Group, West Yorkshire, UK.

Background: The Clinical Practice Research Datalink (CPRD) was used to evaluate the overall costs to the National Health Service, including healthcare utilisation, of prescribing emollients in UK primary care for dry skin and atopic eczema (DS&E).

Methods: Primary care patients in the UK were identified using the CPRD and their records were interrogated for the 2 years following first diagnosis of DS&E. Data from patients with (n = 45,218) and without emollient prescriptions (n = 9780) were evaluated. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-018-0076-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206824PMC
October 2018
25 Reads

Patient-reported outcomes in urticarial vasculitis treated with omalizumab: case report.

BMC Dermatol 2018 10 25;18(1). Epub 2018 Oct 25.

Respiralab, Respiralab Research Group, Guayaquil, Ecuador.

Background: Despite the current knowledge of UV, there is a lack of consensus among diagnostic criteria and management. In general, antihistamine therapy is regularly used for the symptomatic management of pruritus but does not control inflammation or alter the course of the disease. Monoclonal antibodies such as omalizumab (anti-IgE) have been proposed as a potential treatment for urticarial vasculitis. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-018-0077-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203196PMC
October 2018
47 Reads

Acne in Lomé, Togo: clinical aspects and quality of life of patients.

BMC Dermatol 2018 08 22;18(1). Epub 2018 Aug 22.

Dermatology Unit, Sylvanus Olympio Teaching Hospital, University of Lomé, B.P, 30785, Lomé, Togo.

Background: Acne is a chronic inflammatory condition affecting the pilosebaceous follicle that mainly affects adolescents and young adults. The aim of this study was to assess the quality of life (QOL) of patients with acne, and to determine the correlation between the QOL and the severity of acne, in Lomé (Togo).

Method: From July 2017 to February 2018, we conducted a study in three dermatology departments of Lomé. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-018-0075-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106930PMC
August 2018
22 Reads

Expert Consensus on The Management of Dermatophytosis in India (ECTODERM India).

BMC Dermatol 2018 07 24;18(1). Epub 2018 Jul 24.

Department of Dermatology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Background: Dermatophytosis management has become an important public health issue, with a large void in research in the area of disease pathophysiology and management. Current treatment recommendations appear to lose their relevance in the current clinical scenario. The objective of the current consensus was to provide an experience-driven approach regarding the diagnosis and management of tinea corporis, cruris and pedis. Read More

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http://dx.doi.org/10.1186/s12895-018-0073-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057051PMC
July 2018
45 Reads

Persistence rates and medical costs of biological therapies for psoriasis treatment in Japan: a real-world data study using a claims database.

BMC Dermatol 2018 07 11;18(1). Epub 2018 Jul 11.

Health Economics and Outcomes Research, Janssen-Cilag GmbH, Johnson & Johnson Platz 1, Neuss, 41470, Germany.

Background: Biological therapies (BTs) including infliximab (IFX), adalimumab (ADL), secukinumab (SCK) and ustekinumab (UST) are approved in Japan for the treatment of psoriasis. Although the persistence rates and medical costs of BTs treatment have been investigated in multiple foreign studies in recent years, few such studies have been conducted in Japan and the differences between patients who adhered to treatment and those who did not have not been reported. This study is aimed at investigating the persistence rates and medical costs of BTs in the treatment of psoriasis in Japan, using the real-world data from a large-scale claims database. Read More

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http://dx.doi.org/10.1186/s12895-018-0074-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042444PMC
July 2018
6 Reads

Real-world health outcomes in adults with moderate-to-severe psoriasis in the United States: a population study using electronic health records to examine patient-perceived treatment effectiveness, medication use, and healthcare resource utilization.

BMC Dermatol 2018 06 28;18(1). Epub 2018 Jun 28.

Eli Lilly and Company, Indianapolis, IN, USA.

Background: Little is known regarding real-world health outcomes data among US psoriasis patients, but electronic health records (EHR) that collect structured data at point-of-care may provide opportunities to investigate real-world health outcomes among psoriasis patients. Our objective was to investigate patient-perceived treatment effectiveness, patterns of medication use (duration, switching, and/or discontinuation), healthcare resource utilization, and medication costs using real-world data from psoriasis patients.

Methods: Data for adults (≥18-years) with a dermatology provider-given diagnosis of psoriasis from 9/2014-9/2015 were obtained from dermatology practices using a widely used US dermatology-specific EHR containing over 500,000 psoriasis patients. Read More

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http://dx.doi.org/10.1186/s12895-018-0072-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025830PMC
June 2018
16 Reads

Can an app supporting psoriasis patients improve adherence to topical treatment? A single-blind randomized controlled trial.

BMC Dermatol 2018 02 7;18(1). Epub 2018 Feb 7.

Department of Dermatology and Allergy Centre, Odense University Hospital, Kløvervænget 15, 5000, Odense C, Denmark.

Background: Topical corticosteroid or corticosteroid/calcipotriol preparations are recommended first-line topical treatments of psoriasis, but a main cause for the lack of efficacy of topical treatments is considered low rates of adherence to topical drugs. Patient support by the use of applications (apps) for smartphones is suggested to improve medical adherence.

Methods/design: Design: An investigator-initiated, single-center, single-blind, parallel-group, phase-4 clinical superiority randomized controlled trial (RCT). Read More

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http://dx.doi.org/10.1186/s12895-018-0071-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804085PMC
February 2018
7 Reads

Elucidating mechanistic insights into drug action for atopic dermatitis: a systems biology approach.

BMC Dermatol 2018 02 7;18(1). Epub 2018 Feb 7.

LABS, Persistent Systems Limited, 9A/12, Erandwane, Pune, Maharashtra, 411004, India.

Background: Topical Betamethasone (BM) and Pimecrolimus (PC) are widely used drugs in the treatment of atopic dermatitis (AD). Though the biomolecules and biological pathways affected by the drugs are known, the causal inter-relationships among these pathways in the context of skin is not available. We aim to derive this insight by using transcriptomic data of AD skin samples treated with BM and PC using systems biology approach. Read More

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http://dx.doi.org/10.1186/s12895-018-0070-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803917PMC
February 2018
7 Reads

A novel PLEC nonsense homozygous mutation (c.7159G > T; p.Glu2387*) causes epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia: a case report.

BMC Dermatol 2018 01 20;18(1). Epub 2018 Jan 20.

Molecular Genetics and Pathology Unit, Hospital of Divino Espírito Santo of Ponta Delgada, EPER, Av. D. Manuel I, 9500-370, Ponta Delgada, São Miguel Island, Azores, Portugal.

Background: Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD; OMIM #226670) is an autosomal recessive disease, characterized mainly by skin blistering at birth or shortly thereafter, progressive muscle weakness, and rarely by alopecia. EBS-MD is caused by mutations in the PLEC gene (OMIM *601282), which encodes plectin, a structural protein expressed in several tissues, including epithelia and muscle. We describe a patient affected with EBS-MD and diffuse alopecia in which we identified a novel pathogenic mutation by PCR amplification of all coding exons and exon-intron boundaries of PLEC gene, followed by bidirectional Sanger sequencing. Read More

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http://dx.doi.org/10.1186/s12895-018-0069-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775598PMC
January 2018
18 Reads

A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction?

BMC Dermatol 2017 Dec 20;17(1):16. Epub 2017 Dec 20.

Clinical and Experimental Allergy and Immunology Laboratory LIM-56, University of São Paulo Medical School, São Paulo, Brazil.

Background: Erythroderma is characterized by erythema and scaling affecting more than 90% of the body surface area. Inflammatory, neoplastic and, more rarely, infectious diseases may culminate with erythroderma. Diagnosis of the underlying disorder is therefore crucial to institute the appropriate therapy. Read More

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http://dx.doi.org/10.1186/s12895-017-0068-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738805PMC
December 2017
17 Reads

Composite hemangioendothelioma of the forehead and right eye; a case report.

BMC Dermatol 2017 12 12;17(1):15. Epub 2017 Dec 12.

Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Hemangioendothelioma includes several types of vascular neoplasms , as well as both benign and malignant growth.

Case Presentation: This study evaluated a case of a 78-year-old female diagnosed with composite hemangioendothelioma (CHE). This patient had an 18-month history of painless inflammatory lesions and erythema on the left forehead and right upper eyelid. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-017-0067-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727897PMC
December 2017
12 Reads

Assessment of the effects of skin microneedling as adjuvant therapy for facial melasma: a pilot study.

BMC Dermatol 2017 11 28;17(1):14. Epub 2017 Nov 28.

Unesp Medical School, Botucatu, SP, Brazil.

Background: Melasma is a common chronic and relapsing acquired dyschromia. Skin microneedling was reported resulting sustained long-term improvement of recalcitrant melasma, however, the exact mechanism that promotes this skin lightening is not known. This study aimed to investigate clinical and histologic alterations promoted by skin microneedling in facial melasma. Read More

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http://dx.doi.org/10.1186/s12895-017-0066-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706369PMC
November 2017
10 Reads

BAP1: case report and insight into a novel tumor suppressor.

BMC Dermatol 2017 Nov 22;17(1):13. Epub 2017 Nov 22.

Penn Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104, USA.

Background: BRCA1-Associated-Protein 1 (BAP1) is a dynamic tumor suppressor which, when mutated, has been associated with an increased risk of uveal melanoma, cutaneous melanoma, mesothelioma, and several other cancers. Germline BAP1 mutations have been extensively studied, where they have been found to cause hereditary cancer susceptibility. However, their sporadic counterparts, tumors that display a loss of BAP1 expression due to somatically arising mutations in the BAP1 gene, remain a poorly described entity. Read More

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https://bmcdermatol.biomedcentral.com/articles/10.1186/s1289
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http://dx.doi.org/10.1186/s12895-017-0065-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700555PMC
November 2017
121 Reads

Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face - protocol of a multicenter, prospective, randomized, controlled, two-armed study.

BMC Dermatol 2017 10 25;17(1):12. Epub 2017 Oct 25.

Department of Dermatology, University Hospital Regensburg, 93042, Regensburg, Germany.

Background: Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated.

Methods/design: In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery. In the DL-PDT group (experimental group), 5 treatments of the entire face are conducted over the course of 18 months. Read More

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http://bmcdermatol.biomedcentral.com/articles/10.1186/s12895
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http://dx.doi.org/10.1186/s12895-017-0064-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657041PMC
October 2017
11 Reads

Rationale and Design of the Brigham Cohort for psoriasis and psoriatic arthritis registry (COPPAR).

BMC Dermatol 2017 08 16;17(1):11. Epub 2017 Aug 16.

Division of Rheumatology, Department of Medicine of the Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Background: Psoriasis (PsO) and psoriatic arthritis (PsA) are related conditions with poorly defined transition among them, risk factors for progression, complex treatment algorithms, and biomarkers for treatment response and long-term outcomes. We describe the development of a PsO/PsA registry at an academic medical center.

Methods: We developed a single-center PsO/PsA longitudinal disease registry including biorepository that captures relevant disease markers and treatment choices in a circumscribed population with a defined catchment area. Read More

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http://dx.doi.org/10.1186/s12895-017-0063-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559864PMC
August 2017
21 Reads

Prevalence of head lice infestation and pediculicidal effect of permethrine shampoo in primary school girls in a low-income area in southeast of Iran.

BMC Dermatol 2017 07 24;17(1):10. Epub 2017 Jul 24.

Department of Medical Entomology and Vector Control, Faculty of Health, Hormozgan University of Medical Sciences, P.O. Box: 79145-3838, Bandar Abbas, Iran.

Background: Head lice infestation is a common public health problem that is most prevalent in primary school children throughout the world, especially in developing countries including different parts of Iran. This study aimed to determine the prevalence and risk factors associated with head lice infestation and pediculicidal effect of 1% permethrin shampoo in primary schools girls of Bashagard County, one of the low socioeconomic areas in southeast of Iran.

Methods: In this interventional study six villages with similar demographical situations were selected and randomly assigned into intervention and control areas. Read More

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http://bmcdermatol.biomedcentral.com/articles/10.1186/s12895
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http://dx.doi.org/10.1186/s12895-017-0062-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525205PMC
July 2017
12 Reads

Variation of mutant allele frequency in NRAS Q61 mutated melanomas.

BMC Dermatol 2017 07 1;17(1). Epub 2017 Jul 1.

Research Unit EA4340 Biomarkers in Cancerology and Hemato Oncology, Versailles SQY University, Paris-Saclay University, 9, Avenue Charles de Gaulle, 92104, Boulogne-Billancourt, France.

Background: Somatic mutations of BRAF or NRAS activating the MAP kinase cell signaling pathway are present in 70% of cutaneous melanomas. The mutant allele frequency of BRAF V600E (M%BRAF) was recently shown to be highly heterogeneous in melanomas. The present study focuses on the NRAS Q61 mutant allele frequency (M%NRAS). Read More

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http://dx.doi.org/10.1186/s12895-017-0061-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494128PMC
July 2017
37 Reads

SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes.

BMC Dermatol 2017 06 10;17(1). Epub 2017 Jun 10.

School of Medical Science, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA, 6027, Australia.

Background: Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB plus heat exposed keratinocytes. Read More

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http://dx.doi.org/10.1186/s12895-017-0060-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466784PMC
June 2017
10 Reads

Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report.

BMC Dermatol 2017 05 18;17(1). Epub 2017 May 18.

Department of Dermatology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Koch CRB II, Unit 206, Baltimore, MD, 21231, USA.

Background: Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on the acquired form that presents in adulthood. Unlike its inherited counterpart, acquired AE (AAE) is often secondary to underlying pathologic or iatrogenic etiologies that interfere with nutritional absorption, such as inflammatory bowel disease or alcoholism. Read More

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http://dx.doi.org/10.1186/s12895-017-0059-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437591PMC
May 2017
53 Reads

Tight controlled dose reduction of biologics in psoriasis patients with low disease activity: a randomized pragmatic non-inferiority trial.

BMC Dermatol 2017 05 8;17(1). Epub 2017 May 8.

Department of Dermatology, Radboud University Medical Center, Rene Descartesdreef 1, 6525 GL, Nijmegen, The Netherlands.

Background: Psoriasis is an immune-mediated chronic inflammatory skin disorder for which several targeted biologic therapies became available in the last 10 years. Data from patients with rheumatoid arthritis revealed that dose tapering combined with tight control of disease activity is successful. For psoriasis patients the lowest effective dose of biologics needs to be determined. Read More

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http://dx.doi.org/10.1186/s12895-017-0057-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422943PMC
May 2017
56 Reads

Evaluation of therapeutic potential of VB-001, a leave-on formulation, for the treatment of moderate adherent dandruff.

BMC Dermatol 2017 05 3;17(1). Epub 2017 May 3.

Medicine & HST, Brigham and Women's Hospital, Harvard Medical School, Room 317, 65 Landsdowne Street, Cambridge, MA, 02139, USA.

Background: Dandruff is a common scalp condition characterized by excessive scaling and itch. Aberrant colonization of the scalp by commensal Malassezia spp. is a major contributor in the multifactorial etiology of dandruff. Read More

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http://dx.doi.org/10.1186/s12895-017-0058-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415814PMC
May 2017
21 Reads

A prospective analysis of pinch grafting of chronic leg ulcers in a series of elderly patients in rural Cameroon.

BMC Dermatol 2017 03 20;17(1). Epub 2017 Mar 20.

Department of Surgery and Obstetrics/Gynaecology, Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Background: Chronic leg ulcers (CLUs) pose serious public health concerns worldwide. They mainly affect the elderly population. Pinch grafting (PG) could be used to treat a variety of CLUs. Read More

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http://dx.doi.org/10.1186/s12895-017-0056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360079PMC
March 2017
27 Reads

Expression profiling and bioinformatic analyses suggest new target genes and pathways for human hair follicle related microRNAs.

BMC Dermatol 2017 02 22;17(1). Epub 2017 Feb 22.

Institute of Human Genetics, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

Background: Human hair follicle (HF) cycling is characterised by the tight orchestration and regulation of signalling cascades. Research shows that micro(mi)RNAs are potent regulators of these pathways. However, knowledge of the expression of miRNAs and their target genes and pathways in the human HF is limited. Read More

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http://dx.doi.org/10.1186/s12895-017-0054-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322611PMC
February 2017
10 Reads

Skin cancer knowledge and attitudes in the region of Fez, Morocco: a cross-sectional study.

BMC Dermatol 2017 02 17;17(1). Epub 2017 Feb 17.

Department of dermatology, University Hospital Hassan II, 202 Hay Mohamadi, Fez, Morocco.

Background: The prevalence of skin cancers is constantly increasing in Morocco, and they have gradually become more aggressive due to a significant delay in the diagnosis. Our aim was to assess the levels of awareness and the influencing factors related to skin cancer knowledge in Morocco.

Methods: This cross-sectional study was carried out in Morocco through the medium of a validated questionnaire, which contained several items - demographics, skin cancer knowledge and attitudes towards skin cancer patients- during a period of 1 year (2014). Read More

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http://dx.doi.org/10.1186/s12895-017-0055-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316218PMC
February 2017
23 Reads

Knowledge, attitudes and practices of the medical personnel regarding atopic dermatitis in Yaoundé, Cameroon.

BMC Dermatol 2017 02 16;17(1). Epub 2017 Feb 16.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box: 8314, Yaoundé, Cameroon.

Background: Atopic dermatitis (AD) is a chronic, relapsing and pruritic inflammatory skin disease whose management remains unclear to most non-dermatologists. This study aimed to assess the knowledge, attitudes and practices (KAP) of the medical staff regarding AD in Yaoundé, Cameroon.

Methods: This was a cross-sectional study conducted from January to April 2014 in 20 health facilities located in Yaoundé, the capital city of Cameroon. Read More

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http://dx.doi.org/10.1186/s12895-017-0053-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314472PMC
February 2017
24 Reads

Treatment of plaque psoriasis with an ointment formulation of the Janus kinase inhibitor, tofacitinib: a Phase 2b randomized clinical trial.

BMC Dermatol 2016 10 3;16(1):15. Epub 2016 Oct 3.

Pfizer Worldwide Biopharmaceuticals, Global Innovative Pharma Business, Groton, CT, USA.

Background: Most psoriasis patients have mild to moderate disease, commonly treated topically. Current topical agents have limited efficacy and undesirable side effects associated with long-term use. Tofacitinib is a small molecule Janus kinase inhibitor investigated for the topical treatment of psoriasis. Read More

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http://dx.doi.org/10.1186/s12895-016-0051-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048458PMC
October 2016
67 Reads

Cutaneous sarcoidosis masquerading as chronic cutaneous lupus erythematosus - case report.

BMC Dermatol 2016 09 20;16(1):14. Epub 2016 Sep 20.

Cancer Treatment and Research Center, Mail Code 7876, 7979 Wurzbach Road, San Antonio, TX, 78229-4427, USA.

Background: Sarcoidosis is a multisystemic granulomatous disease of unknown origin. Chronic cutaneous lupus erythematosus (CCLE) is an autoimmune disease that is associated with autoantibody production and T-cell dysfunction. Cutaneous manifestations of sarcoidosis may mimic CCLE and vice versa making it difficult to reach a diagnosis clinically. Read More

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http://bmcdermatol.biomedcentral.com/articles/10.1186/s12895
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http://dx.doi.org/10.1186/s12895-016-0052-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028922PMC
September 2016
13 Reads

Risk factors of keloids in Syrians.

BMC Dermatol 2016 09 20;16(1):13. Epub 2016 Sep 20.

Department of Plastic and Reconstructive Surgery, Tishreen University, Lattakia, Syria.

Background: Keloid is a benign fibrous growth, which presents in scar tissue of predisposed individuals. It is a result of irregular wound healing, but the exact mechanism is unknown. However, several factors may play a role in keloid formation. Read More

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http://dx.doi.org/10.1186/s12895-016-0050-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028955PMC
September 2016
25 Reads