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    3113 results match your criteria BMC Complementary and Alternative Medicine [Journal]

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    A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis.
    BMC Complement Altern Med 2017 Nov 22;17(1):495. Epub 2017 Nov 22.
    Department of Physiology, Faculty of Medicine, Helwan University, Cairo, 11795, Egypt.
    Background: Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model.

    Methods: Thirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Read More

    Phytochemical and pharmacological evaluation of ethanolic extract of Lepisanthes rubiginosa L. leaves.
    BMC Complement Altern Med 2017 Nov 22;17(1):496. Epub 2017 Nov 22.
    Pharmacy Discipline, Life Science School, Khulna University, Khulna, 9208, Bangladesh.
    Background: The current study was conducted to evaluate the antioxidant, analgesic, antihyperglycemic, neuropharmacological and antidiarrheal activities of ethanolic extract of Lepisanthes rubiginosa L. leaves in different experimental models.

    Methods: Quantitative and qualitative analysis were done by TLC (thin layer chromatography) and DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging assay. Read More

    In vitro cytotoxic activity of medicinal plants from Nigeria ethnomedicine on Rhabdomyosarcoma cancer cell line and HPLC analysis of active extracts.
    BMC Complement Altern Med 2017 Nov 22;17(1):494. Epub 2017 Nov 22.
    Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
    Background: Cancer is a leading cause of death world-wide, with approximately 17.5 million new cases and 8.7 million cancer related deaths in 2015. Read More

    Pharmacological potential of Bidens pilosa L. and determination of bioactive compounds using UHPLC-QqQLIT-MS/MS and GC/MS.
    BMC Complement Altern Med 2017 Nov 16;17(1):492. Epub 2017 Nov 16.
    Department of Biotechnology, Mizoram University, Aizawl, Mizoram, 796004, India.
    Background: Research of natural products from traditionally used medicinal plants to fight against the human ailments is fetching attention of researchers worldwide. Bidens pilosa Linn. var. Read More

    Blockade of nicotine sensitization by methanol extracts of Glycyrrhizae radix mediated via antagonism of accumbal oxidative stress.
    BMC Complement Altern Med 2017 Nov 16;17(1):493. Epub 2017 Nov 16.
    School of Mental Health, Qiqihar Medical University, 333 Bukuibei Street, Jianhua District, Qiqihar, 161006, China.
    Background: We previously reported that a methanol extract of Glycyrrhizae radix (MEGR) blocked methamphetamine-induced locomotor sensitization and conditioned place preference in rats. In the present study, the effects of MEGR on repeated nicotine-induced locomotor sensitization and enhanced extracellular dopamine (DA) release in the nucleus accumbens (Nacc) were evaluated.

    Methods: Male Sprague-Dawley rats received repeated administrations of nicotine (0. Read More

    Molecular network-based analysis of the mechanism of liver injury induced by volatile oils from Artemisiae argyi folium.
    BMC Complement Altern Med 2017 Nov 16;17(1):491. Epub 2017 Nov 16.
    Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
    Background: Volatile oils from Artemisiae argyi folium (VOAAF) is reported with hepatotoxicity, but the underlying mechanism is still unclear.

    Methods: In the present study this molecular mechanism was explored with the Ingenuity Pathway Analysis (IPA). The chemical components of the VOAAF were searched in the database, and their target proteins were all identified in the PubChem, while drug-induced liver injury (DILI) genes were searched in the PubMed gene databases. Read More

    Integrative medicine primary care: assessing the practice model through patients' experiences.
    BMC Complement Altern Med 2017 Nov 15;17(1):490. Epub 2017 Nov 15.
    University of Arizona Center for Integrative Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA.
    Background: The University of Arizona Integrative Health Center (UAIHC) was an innovative integrative medicine (IM) adult primary care clinic in Phoenix, Arizona. UAIHC used a hybrid payment model to deliver comprehensive healthcare that includes conventional and complementary medical treatments.

    Methods: Fidelity measures were collected to evaluate how well the IM care delivery process matched ideals for IM. Read More

    Safety classification of herbal medicines used among pregnant women in Asian countries: a systematic review.
    BMC Complement Altern Med 2017 Nov 14;17(1):489. Epub 2017 Nov 14.
    Department of Global Health and Development & Department of Preventive Medicine, Hanyang University, College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.
    Background: High prevalence of herbal medicines used in pregnancy and the lack of information on their safety is a public concern. Despite this, no significant research has been done regarding potential adverse effects of using herbal medicines during pregnancy, especially among developing Asian countries.

    Methods: Cross-sectional studies were searched up to year 2016 on PubMed/Medline and EMBASE, the data were extracted and quality of studies was assessed using the quality appraisal tool. Read More

    Thai plants with high antioxidant levels, free radical scavenging activity, anti-tyrosinase and anti-collagenase activity.
    BMC Complement Altern Med 2017 Nov 9;17(1):487. Epub 2017 Nov 9.
    Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
    Background: Ultraviolet radiation from sunlight induces overproduction of reactive oxygen species (ROS) resulting in skin photoaging and hyperpigmentation disorders. Novel whitening and anti-wrinkle compounds from natural products have recently become of increasing interest. The purpose of this study was to find products that reduce ROS in 14 Thai plant extracts. Read More

    Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats.
    BMC Complement Altern Med 2017 Nov 9;17(1):488. Epub 2017 Nov 9.
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
    Background: Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. Read More

    Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro.
    BMC Complement Altern Med 2017 Nov 6;17(1):486. Epub 2017 Nov 6.
    Gachon medical research institute, Gachon University Gil Medical Center, 21 Namdong-daero 774 beon-gil, Namdong-gu, Incheon, 405-760, Republic of Korea.
    Background: Coix lacryma-jobi var. ma-yuen (Rom.Caill. Read More

    Potential effectiveness of Chinese herbal medicine Yu ping feng san for adult allergic rhinitis: a systematic review and meta-analysis of randomized controlled trials.
    BMC Complement Altern Med 2017 Nov 6;17(1):485. Epub 2017 Nov 6.
    The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Yuexiu District, Guangzhou, 510120, China.
    Background: Chinese herbal medicine formula Yu ping feng san (YPFS) is commonly used for allergic rhinitis (AR). Previous review had summarized the effectiveness and safety of YPFS, however without any subgroup analysis performed to provide detailed evidence for guiding clinical practice. YPFS was recommended for the management of AR by Chinese medicine clinical practice guideline, but the treatment duration of YPFS was also not specified. Read More

    Antibacterial, antioxidant and Immuno-modulatory properties in extracts of Barleria lupulina Lindl.
    BMC Complement Altern Med 2017 Nov 3;17(1):484. Epub 2017 Nov 3.
    Department of Botany & Microbiology, Gurukul Kangri University, Haridwar, 249404, India.
    Background: Antibacterial, immunomodulatory and antioxidant properties of aerial parts of Barleria lupulina Lindl were investigated in the present communication.

    Methods: The antibacterial, antioxidant and immunomodulatory properties of B. lupulina (methanol soluble leaf and stem extracts) was analyzed by minimum inhibitory concentration, total phenolic contents, DPPH radical scavenging activity, determination of toxicity, hemagglutination antibody titre, delayed type hypersensitivity and neutrophil adhesion test, respectively. Read More

    Water extract of Rumex crispus prevents bone loss by inhibiting osteoclastogenesis and inducing osteoblast mineralization.
    BMC Complement Altern Med 2017 Oct 26;17(1):483. Epub 2017 Oct 26.
    KM Application Center, Korea Institute of Oriental Medicine, 70 Chemdan-ro, Dong-gu, 41062, Daegu, 701-300, Republic of Korea.
    Background: Rumex crispus root has traditionally been used in Asian medicine for the treatment of hemorrhage and dermatolosis. The aim of this study was to explore the pharmaceutical effects of water extract of Rumex crispus (WERC) on osteoblast and osteoclast differentiation. We also studied the effect of WERC on the receptor activator of nuclear factor kappa-B ligand (RANKL)-induced trabecular bone destruction mice model. Read More

    Defatting of acetone leaf extract of Acacia karroo (Hayne) enhances its hypoglycaemic potential.
    BMC Complement Altern Med 2017 Oct 23;17(1):482. Epub 2017 Oct 23.
    Department of Biochemistry, Microbiology and Biotechnology, Faculty of Science and Agriculture, University of Limpopo, Turfloop Campus, Private Bag X1106, Sovenga, Limpopo, 0727, South Africa.
    Background: Conventional drugs used to treat diabetes are too expensive, toxic and rarely available to rural communities. This study was aimed at investigating the phytochemical differences and hypoglycaemic effects (α-amylase enzyme inhibition, glucose uptake, GLUT4 translocation and phosphorylation of MAPKs) of non-defatted and defatted acetone leaf extract of Acacia karroo.

    Methods: Qualitative phytochemical analyses of extracts were determined using standard chemical tests and total phenolic contents using the Folin-Ciocalteu reagent method. Read More

    Balneotherapeutic effects of high mineral spring water on the atopic dermatitis-like inflammation in hairless mice via immunomodulation and redox balance.
    BMC Complement Altern Med 2017 Oct 13;17(1):481. Epub 2017 Oct 13.
    Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon, 26426, Republic of Korea.
    Background: Atopic dermatitis (AD) is a chronic relapsing allergic inflammatory skin disease that currently affects millions of children and adults worldwide. Drugs used to treat these inflammatory diseases include anti-histamines, corticosteroids and calcineurin inhibitors but these drugs have their limitations such as adverse effects with their long-term usage. Thus, researcher's interest in several alternative and complementary therapies are continually growing and balneotherapy is one of these approaches. Read More

    Electroacupuncture ameliorating post-stroke cognitive impairments via inhibition of peri-infarct astroglial and microglial/macrophage P2 purinoceptors-mediated neuroinflammation and hyperplasia.
    BMC Complement Altern Med 2017 Oct 10;17(1):480. Epub 2017 Oct 10.
    College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China.
    Background: During ischemic stroke (IS), adenosine 5'-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors singling, and causing pro-inflammatory cytokine secretion, which is likely to initiate or aggravate motor and cognitive impairment. It has been proved that electroacupuncture (EA) is an effective and safe strategy used in anti-inflammation. However, EA for the role of purine receptors in the central nervous system has not yet been reported. Read More

    Bidens pilosa Ethylene acetate extract can protect against L-NAME-induced hypertension on rats.
    BMC Complement Altern Med 2017 Oct 10;17(1):479. Epub 2017 Oct 10.
    Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
    Background: Essential hypertension is mainly caused by endothelial dysfunction which results from nitric oxide (NO) deficiency. The present study was design to evaluate the protective effect of Bidens pilosa ethylene acetate extract (Bp) on L-NAME induced hypertension and oxidative stress in rats.

    Methods: Male Wistar rats were used to induce hypertension by the administration of L-NAME (a non-pecific nitric oxide inhibitor) (50 mg/kg/day). Read More

    Resveratrol enhances anticancer effects of paclitaxel in HepG2 human liver cancer cells.
    BMC Complement Altern Med 2017 Oct 4;17(1):477. Epub 2017 Oct 4.
    Department of Hepatobiliary & Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
    Background: The aim of this in vitro study was to measure the enhanced anticancer effects of Res (resveratrol) on PA (paclitaxel) in HepG2 human liver cancer cells.

    Methods: The MTT (thiazolyl blue tetrazolium bromide, 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide), flow cytometry, qPCR (real-time quantitative polymerase chain reaction) and western blot assay were used for cells growth inhibitory effects, cells apoptosis (DNA content of sub-G1), mRNA and protein expressions, respectively.

    Results: The 10 μg/mL of Res had no growth inhibitory effect on Nthy-ori 3-1 normal cells or HepG2 cancer cells meanwhile the 5 or 10 μg/mL of PA also had no growth inhibitory effect on Nthy-ori 3-1 normal cells. Read More

    Correction to: Moon phases and Moon signs do not influence morbidity, mortality and long-term survival, after living donor kidney transplantation.
    BMC Complement Altern Med 2017 Oct 4;17(1):478. Epub 2017 Oct 4.
    Department of General-, Visceral-, Vascular- and Transplant Surgery, University of Munich, Marchioninistrasse 15, 81377, Munich, Germany.

    Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings.
    BMC Complement Altern Med 2017 Oct 2;17(1):474. Epub 2017 Oct 2.
    Department of Herbology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
    Background: Hypertension is one of the most important risk factors for cardiovascular disease (CVD) and a worldwide problem. Despite increases in the development of synthetic drugs for hypertension treatment, the rate of untreated and uncontrolled hypertension remains high. These drugs are effective, but can also cause side effects. Read More

    Effects of dietary supplementation with a standardized aqueous extract of Terminalia chebula fruit (AyuFlex(®)) on joint mobility, comfort, and functional capacity in healthy overweight subjects: a randomized placebo-controlled clinical trial.
    BMC Complement Altern Med 2017 Oct 2;17(1):475. Epub 2017 Oct 2.
    Division of Sports Nutrition and Exercise Science, The Center for Applied Health Sciences, 4302 Allen Road, Suite 120, Stow, OH, 44224, USA.
    Background: Joint and connective tissue integrity, comfort and function are paramount to optimal performance in exercise, recreational and occupational activities. The fruit of Terminalia chebula has been used extensively in various traditional health systems for different ailments, with additional preclinical and clinical data demonstrating antioxidant and anti-inflammatory potential. The aim of this study was to evaluate the effects of a standardized aqueous extract of Terminalia chebula fruit (AyuFlex®) dietary supplementation on joint mobility, comfort, and functional capacity in healthy overweight subjects. Read More

    Protective effects of methanolic extract of Juglans regia L. leaf on streptozotocin-induced diabetic peripheral neuropathy in rats.
    BMC Complement Altern Med 2017 Oct 2;17(1):476. Epub 2017 Oct 2.
    Immunogenetic Research Center and Department of Physiology and Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Oxidative stress has a pivotal role in the pathogenesis and development of diabetic peripheral neuropathy (DPN), the most common and debilitating complications of diabetes mellitus. There is accumulating evidence that Juglans regia L. (GRL) leaf extract, a rich source of phenolic components, has hypoglycemic and antioxidative properties. Read More

    Anti-inflammatory and analgesic activities of solvent fractions of the leaves of Moringa stenopetala Bak. (Moringaceae) in mice models.
    BMC Complement Altern Med 2017 Sep 29;17(1):473. Epub 2017 Sep 29.
    Department of pharmacology and clinical pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
    Background: Many people still experience pain and inflammation regardless of the available drugs for treatments. In addition, the available drugs have many side effects, which necessitated a quest for new drugs from several sources in which medicinal plants are the major one. This study evaluated the analgesic and anti- inflammatory activity of the solvent fractions of Moringa stenopetala in rodent models of pain and inflammation. Read More

    Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model.
    BMC Complement Altern Med 2017 Sep 29;17(1):472. Epub 2017 Sep 29.
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Kingdom of Saudi Arabia.
    Background: Cisplatin is widely used chemotherapeutic agent for cancer treatment with limited uses due to its neurotoxic side effect. The aim of this study was to determine the potential preventive effects of rutin on the brain of cisplatin- neurotoxic rat model.

    Methods: Forty rats were divided into four groups. Read More

    The ameliorative effect of bloodletting puncture at hand twelve Jing-well points on cerebral edema induced by permanent middle cerebral ischemia via protecting the tight junctions of the blood-brain barrier.
    BMC Complement Altern Med 2017 Sep 26;17(1):470. Epub 2017 Sep 26.
    Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.
    Background: Cerebral edema, erupting simultaneously with severe ischemic stroke, might lead to increased intracranial pressure, cerebral herniation, and ultimately death. Studies conducted previously by our team have demonstrated the fact that bloodletting puncture at hand twelve Jing-well points (HTWP) could alleviate cerebral edema, which mainly results from the disruption of blood-brain barrier (BBB). The study, therefore, was first designed to demonstrate whether BBB-protection serves an important role in the edema-relief effect of HTWP bloodletting, based on which to research the molecular mechanism underlying. Read More

    Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy.
    BMC Complement Altern Med 2017 Sep 26;17(1):471. Epub 2017 Sep 26.
    School of Life Science, Liaocheng University, Liaocheng, 252059, China.
    Background: Propolis and its major constituent - caffeic acid phenethyl ester (CAPE) have good abilities on antitumor and anti-inflammation. However, little is known about the actions of propolis and CAPE on tumor in inflammatory microenvironment, and inflammatory responses play decisive roles at different stages of tumor development. To understand the effects and mechanisms of ethanol-extracted Chinese propolis (EECP) and its major constituent - CAPE in inflammation-stimulated tumor, we investigated their effects on Toll-like receptor 4 (TLR4) signaling pathway which plays a crucial role in breast cancer MDA-MB-231 cell line. Read More

    Aqueous root extract of Asparagus cochinchinensis (Lour.) Merr. Has antioxidant activity in D-galactose-induced aging mice.
    BMC Complement Altern Med 2017 Sep 25;17(1):469. Epub 2017 Sep 25.
    College of Horticulture and Landscape, Hunan Agriculture University, Changsha, Hunan, 410128, China.
    Background: Extracts of plants have been considered as sources of natural antioxidant agents. In this study, we aimed to explore the antioxidant capacity of the aqueous root extract of Asparagus cochinchinensis (Lour.) Merr. Read More

    Extract from mango mistletoes Dendrophthoe pentandra ameliorates TNBS-induced colitis by regulating CD4+ T cells in mesenteric lymph nodes.
    BMC Complement Altern Med 2017 Sep 25;17(1):468. Epub 2017 Sep 25.
    Departement of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, East Java, Indonesia.
    Background: Mango mistletoes Dendrophthoe pentandra (MMDP) extract has attracted interest due to its pharmacological properties, including gastro protective effects. The aim of this study was to investigate whether MMDP extract could increase Foxp3 regulatory T cells and inhibits development of Th17 cells.

    Methods: Colitis was induced in Balb/c mice by rectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS). Read More

    Post-market outcome of an extract of traditional Cretan herbs on upper respiratory tract infections: a pragmatic, prospective observational study.
    BMC Complement Altern Med 2017 Sep 21;17(1):466. Epub 2017 Sep 21.
    Clinic of Social and Family Medicine, School of Medicine, University of Crete, P.O. Box 2208, 71003, Heraklion, Greece.
    Background: The beneficial effects of traditional herbs of Crete, Greece for the treatment of upper respiratory tract infections have been reported in observational and laboratory studies. Following a published, double blind, randomized, placebo controlled trial, this study aimed to assess the effectiveness of an extract of three Cretan herbs on the treatment of upper respiratory tract infections, upon its market release.

    Methods: An observational study was conducted in Heraklion, Crete, Greece. Read More

    Effectiveness of acupuncture for breast cancer related lymphedema: protocol for a single-blind, sham-controlled, randomized, multicenter trial.
    BMC Complement Altern Med 2017 Sep 21;17(1):467. Epub 2017 Sep 21.
    Department of Clinical Laboratory, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China.
    Background: Although various treatments for breast cancer related lymphedema exist, there is still a need for a more effective and convenient approach. Pilot studies and our clinical observations suggested that acupuncture may be a potential option. This study aims to verify the effectiveness of acupuncture on BCRL and evaluate its safety using a rigorously designed trial. Read More

    A pilot single centre, double blind, placebo controlled, randomized, parallel study of Calmagen® dermaceutical cream and lotion for the topical treatment of tinea and onychomycosis.
    BMC Complement Altern Med 2017 Sep 18;17(1):464. Epub 2017 Sep 18.
    Xerion Limited, Brighton, Victoria, 3186, Australia.
    Background: Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therapies. The study aimed to establish the fungicidal, efficacy and safety profile of Calmagen® dermaceutical cream and lotion containing AMYCOT® as a topical treatment in patients with severe to very severe presentations of fungal skin (tinea) and nail infections (onychomycosis).

    Methods: A randomized, placebo-controlled, double blind, parallel, single centre study was conducted on 28 subjects with severe to very severe tinea or onychomycosis. Read More

    Safety of intravenously applied mistletoe extract - results from a phase I dose escalation study in patients with advanced cancer.
    BMC Complement Altern Med 2017 Sep 18;17(1):465. Epub 2017 Sep 18.
    Clinical Research Dr. Tröger, Freiburg, Germany.
    Background: Mistletoe extracts have anti-tumor properties and are approved for subcutaneous use in cancer patients. Data on Intravenous application are limited.

    Methods: An aqueous extract from pine-mistletoe was used to investigate maximum tolerable dose (MTD) and safety of intravenous application. Read More

    Changes in trust and the use of Korean medicine in South Korea: a comparison of surveys in 2011 and 2014.
    BMC Complement Altern Med 2017 Sep 16;17(1):463. Epub 2017 Sep 16.
    Policy Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 34054, South Korea.
    Background: Korean medicine (KM) has been widely used in Korea. This study aimed to assess the general perceptions of KM, to investigate the patterns of its usage in 2014, and to compare the results with those of an earlier survey from 2011.

    Methods: A cross-sectional study was conducted with 1000 Korean people. Read More

    Plectranthus amboinicus essential oil and carvacrol bioactive against planktonic and biofilm of oxacillin- and vancomycin-resistant Staphylococcus aureus.
    BMC Complement Altern Med 2017 Sep 16;17(1):462. Epub 2017 Sep 16.
    Master's Program in Biotechnology, INTA College, Sobral, 62050-100, Brazil.
    Background: The emergence of multidrug-resistant bacteria is a worldwide concern and in order to find an alternative to this problem, the occurrence of antimicrobial compounds in Plectranthus amboinicus essential oil was investigated. Thus, this study aims to determine susceptibility of Staphylococcus aureus isolated from food to antibiotics, P. amboinicus essential oil (PAEO) and carvacrol. Read More

    Phytochemical-rich foods inhibit the growth of pathogenic trichomonads.
    BMC Complement Altern Med 2017 Sep 13;17(1):461. Epub 2017 Sep 13.
    Healthy Processed Foods Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA, 94710, USA.
    Background: Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were active against pathogenic foodborne bacteria. Trichomonads produce disease (trichomoniasis) in humans and in certain animals. Read More

    Comparative study on alkaloids and their anti-proliferative activities from three Zanthoxylum species.
    BMC Complement Altern Med 2017 Sep 12;17(1):460. Epub 2017 Sep 12.
    Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Moshan, Wuchang, Wuhan, 430074, China.
    Background: Alkaloids have been considered as the most promising bioactive ingredients in plant species from the genus Zanthoxylum. This study reports on the compositions and contents of the Zanthoxylum alkaloids (ZAs) from three Zanthoxylum species, and their potential anti-proliferation activities.

    Methods: An HPLC-UV/ESI-MS/MS method was established and employed to analyze the alkaloids in different Zanthoxylum extracts. Read More

    Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients.
    BMC Complement Altern Med 2017 Sep 11;17(1):459. Epub 2017 Sep 11.
    Seventh People's Hospital of Shanghai University of TCM, No.358 Datong Road, Gaoqiao Town, Pudong New District, Shanghai, 200137, China.
    Background: Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) body constitution and serum cytokines, and whether body constitution could independently predict diabetes in IGR subjects. Read More

    Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd).
    BMC Complement Altern Med 2017 Sep 11;17(1):457. Epub 2017 Sep 11.
    Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, -576104, India.
    Background: Tinospora cordifolia (Guduchi or Amrita) is an important drug of Ayurvedic System of Medicine and found mention in various classical texts for the treatment of diseases such as jaundice, fever, diabetes, cancer and skin disease etc. In view of its traditional claims, antioxidant and anti-proliferative activities were evaluated in the present study.

    Methods: Ethanol extract (TCE) and subsequent petroleum ether (TCP), dichloromethane (TCD), n-Butanol (TCB) and aqueous (TCA) fractions of were prepared from stems of T cordifolia. Read More

    Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA).
    BMC Complement Altern Med 2017 Sep 11;17(1):458. Epub 2017 Sep 11.
    Department of Zoology and Aquaculture, Acharya Nagarjuna University, Nagarjuna Nagar 522510, Guntur district, Andhra Pradesh, India.
    Background: The objective of the current study was to assess the in vitro antiplasmodial activities of leaf, bark, flower, and the root of Pongamia pinnata against chloroquine-sensitive Plasmodium falciparum (3D7 strain), cytotoxicity against Brine shrimp larvae and THP-1 cell line. For in vivo study, the plant extract which has shown potent in vitro antimalarial activity was tested against Plasmodium berghei (ANKA strain).

    Methods: The plant Pongamia pinnata was collected from the herbal garden of Acharya Nagarjuna University of Guntur district, Andhra Pradesh, India. Read More

    Modulation of hippocampal neuronal activity by So-ochim-tang-gamibang in mice subjected to chronic restraint stress.
    BMC Complement Altern Med 2017 Sep 9;17(1):456. Epub 2017 Sep 9.
    Department of Neuropsychiatry, Dunsan Korean Medicine Hospital of Daejeon University, Daejeon, 35235, Republic of Korea.
    Background: So-ochim-tang-gamibang (SOCG) is a decoction formula which has been used to improve mental activity in traditional Korean medicine. The present study was performed to evaluate whether the treatment of SOCG was involved in activating hippocampal neurons in mice which were subjected to chronic restraint stress (CRS).

    Methods: Mice were subjected to CRS for 2 weeks to induce depressive-like behaviors. Read More

    Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats.
    BMC Complement Altern Med 2017 Sep 8;17(1):455. Epub 2017 Sep 8.
    Gastroenterology Department, NanLou Clinic, General Hospital of People's Liberation Army, Beijing, 100853, People's Republic of China.
    Background: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of taurine, tea polyphenols (TPs), or a combination thereof, on NASH rats.

    Methods: Rats were divided into a normal group, a high-fat diet induced model group and a treatment group (including taurine, TPs, or taurine + TPs treatment for 8 weeks). Read More

    Radix Puerariae and Fructus Crataegi mixture inhibits renal injury in type 2 diabetes via decreasing of AKT/PI3K.
    BMC Complement Altern Med 2017 Sep 8;17(1):454. Epub 2017 Sep 8.
    Runliang Diabetes Laboratory, Diabetes Research Center, School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo City, 315211, Zhejiang, People's Republic of China.
    Background: Radix puerariae (RP) is a herbal medicines for diabetes, mainly because of anti-oxidative, insulin resistance and hypoglycemic effect. Fructus crataegi (FC) also possesses strong antioxidant activity in vitro. This study focused on the effects of herbal mixture of RP and FC (RPFC) on renal protection through a diabetic rat model. Read More

    Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives?
    BMC Complement Altern Med 2017 Sep 7;17(1):453. Epub 2017 Sep 7.
    Interdepartmental Centre for Industrial Agri-Food Research, University of Bologna, Piazza Goidanich 60, 47521, Cesena, Italy.
    Background: Foodstuffs of both plant and animal origin contain a wide range of bioactive compounds. Although human intervention studies are mandatory to assess the health effects of bioactives, the in vitro approach is often used to select the most promising molecules to be studied in vivo. To avoid misleading results, concentration and chemical form, exposure time, and potential cytotoxicity of the tested bioactives should be carefully set prior to any other experiments. Read More

    Assessing the quality of reports about randomized controlled trials of scalp acupuncture combined with another treatment for stroke.
    BMC Complement Altern Med 2017 Sep 6;17(1):452. Epub 2017 Sep 6.
    Department of Physical & Rehabilitation Medicine, Chonnam National University Medical School and Hospital, Gwangju City, Republic of Korea.
    Background: This study was designed to assess the quality of reporting on randomized controlled trials (RCTs) of scalp acupuncture for the treatment of stroke.

    Methods: The following 8 databases were systematically investigated from their inception to December 2015: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, National Institute of Informatics Scholarly and Academic Information Navigator, National Digital Science Library, Korean Traditional Knowledge Portal, and Korean Studies Information Service System. RCTs utilizing scalp acupuncture as an intervention for stroke were selected, and the quality of reports was assessed based on the Consolidated Standards of Reporting Trials 2010 statement (CONSORT) and Standards for Reporting Interventions in Controlled Trials of Acupuncture 2010 (STRICTA). Read More

    Subchronic toxicity of herbal compound "Jiedu Huayu" granules in rats.
    BMC Complement Altern Med 2017 Sep 6;17(1):450. Epub 2017 Sep 6.
    Department of Liver Disease, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi Province, 530023, China.
    Background: "Jiedu Huayu" (JDHY) granules are traditional Chinese herbal compounds that have been used to treat severe liver injury for many years. The purpose of the current study is to evaluate the safety of JDHY granules.

    Methods: Subchronic toxicity was tested in male and female rats that were orally administered three different doses (80, 100, and 130 g/kg/d) of JDHY for 13 weeks. Read More

    Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb.) water extract prevents DSS-induced colitis in mice by up-regulating type II T helper immune responses.
    BMC Complement Altern Med 2017 Sep 6;17(1):448. Epub 2017 Sep 6.
    Department of Integrative Bioscience and Biotechnology, Institute of Anticancer Medicine Development, Sejong University, Seoul, 143-747, South Korea.
    Background: Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders that are mediated by pathogenic Th1 and Th17 cells. Previous studies have demonstrated that taheebo water extract (TWE) derived from Tabebuia avellanedae Lorentz ex Griseb., as folk remedy, has been used to treat various inflammatory diseases. Read More

    Gypenosides ameliorate memory deficits in MPTP-lesioned mouse model of Parkinson's disease treated with L-DOPA.
    BMC Complement Altern Med 2017 Sep 6;17(1):449. Epub 2017 Sep 6.
    Department of Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea.
    Background: Previous studies have revealed that gypenosides (GPS) improve the symptoms of anxiety disorders in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned rat model of Parkinson's disease (PD). The present study aimed to investigate the effects of GPS on memory deficits in an MPTP-lesioned mouse model of PD treated with L-3,4-dihydroxyphenylalanine (L-DOPA).

    Methods: MPTP (30 mg/kg/day, 5 days)-lesioned mice were treated with GPS (50 mg/kg) and/or L-DOPA (10 and 25 mg/kg) for 21 days. Read More

    A national survey of Chinese medicine doctors and clinical practice guidelines in China.
    BMC Complement Altern Med 2017 Sep 6;17(1):451. Epub 2017 Sep 6.
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Nanxiaojie, Beijing, 100700, China.
    Background: Clinical practice guidelines (CPGs) for Chinese medicine (CM) are being developed to assist doctors with appropriate decisions concerning CM care. To date, there has been little investigation on the perspectives of those to whom the guidelines are directed.

    Methods: A self-administered questionnaire was sent to 4503 doctors in 28 provinces of China in the latter half of 2012. Read More

    Isolation and characterization of the compounds responsible for the antimutagenic activity of Combretum microphyllum (Combretaceae) leaf extracts.
    BMC Complement Altern Med 2017 Sep 6;17(1):446. Epub 2017 Sep 6.
    Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa.
    Background: Mutations play a major role in the pathogenesis and development of several chronic degenerative diseases including cancer. It follows, therefore that antimutagenic compound may inhibit the pathological process resulting from exposure to mutagens. Investigation of the antimutagenic potential of traditional medicinal plants and compounds isolated from plant extracts provides one of the tools that can be used to identify compounds with potential cancer chemopreventive properties. Read More

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