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    3082 results match your criteria BMC Complementary and Alternative Medicine [Journal]

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    A pilot single centre, double blind, placebo controlled, randomized, parallel study of Calmagen® dermaceutical cream and lotion for the topical treatment of tinea and onychomycosis.
    BMC Complement Altern Med 2017 Sep 18;17(1):464. Epub 2017 Sep 18.
    Xerion Limited, Brighton, Victoria, 3186, Australia.
    Background: Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therapies. The study aimed to establish the fungicidal, efficacy and safety profile of Calmagen® dermaceutical cream and lotion containing AMYCOT® as a topical treatment in patients with severe to very severe presentations of fungal skin (tinea) and nail infections (onychomycosis).

    Methods: A randomized, placebo-controlled, double blind, parallel, single centre study was conducted on 28 subjects with severe to very severe tinea or onychomycosis. Read More

    Safety of intravenously applied mistletoe extract - results from a phase I dose escalation study in patients with advanced cancer.
    BMC Complement Altern Med 2017 Sep 18;17(1):465. Epub 2017 Sep 18.
    Clinical Research Dr. Tröger, Freiburg, Germany.
    Background: Mistletoe extracts have anti-tumor properties and are approved for subcutaneous use in cancer patients. Data on Intravenous application are limited.

    Methods: An aqueous extract from pine-mistletoe was used to investigate maximum tolerable dose (MTD) and safety of intravenous application. Read More

    Changes in trust and the use of Korean medicine in South Korea: a comparison of surveys in 2011 and 2014.
    BMC Complement Altern Med 2017 Sep 16;17(1):463. Epub 2017 Sep 16.
    Policy Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 34054, South Korea.
    Background: Korean medicine (KM) has been widely used in Korea. This study aimed to assess the general perceptions of KM, to investigate the patterns of its usage in 2014, and to compare the results with those of an earlier survey from 2011.

    Methods: A cross-sectional study was conducted with 1000 Korean people. Read More

    Plectranthus amboinicus essential oil and carvacrol bioactive against planktonic and biofilm of oxacillin- and vancomycin-resistant Staphylococcus aureus.
    BMC Complement Altern Med 2017 Sep 16;17(1):462. Epub 2017 Sep 16.
    Master's Program in Biotechnology, INTA College, Sobral, 62050-100, Brazil.
    Background: The emergence of multidrug-resistant bacteria is a worldwide concern and in order to find an alternative to this problem, the occurrence of antimicrobial compounds in Plectranthus amboinicus essential oil was investigated. Thus, this study aims to determine susceptibility of Staphylococcus aureus isolated from food to antibiotics, P. amboinicus essential oil (PAEO) and carvacrol. Read More

    Phytochemical-rich foods inhibit the growth of pathogenic trichomonads.
    BMC Complement Altern Med 2017 Sep 13;17(1):461. Epub 2017 Sep 13.
    Healthy Processed Foods Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA, 94710, USA.
    Background: Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were active against pathogenic foodborne bacteria. Trichomonads produce disease (trichomoniasis) in humans and in certain animals. Read More

    Comparative study on alkaloids and their anti-proliferative activities from three Zanthoxylum species.
    BMC Complement Altern Med 2017 Sep 12;17(1):460. Epub 2017 Sep 12.
    Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Moshan, Wuchang, Wuhan, 430074, China.
    Background: Alkaloids have been considered as the most promising bioactive ingredients in plant species from the genus Zanthoxylum. This study reports on the compositions and contents of the Zanthoxylum alkaloids (ZAs) from three Zanthoxylum species, and their potential anti-proliferation activities.

    Methods: An HPLC-UV/ESI-MS/MS method was established and employed to analyze the alkaloids in different Zanthoxylum extracts. Read More

    Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients.
    BMC Complement Altern Med 2017 Sep 11;17(1):459. Epub 2017 Sep 11.
    Seventh People's Hospital of Shanghai University of TCM, No.358 Datong Road, Gaoqiao Town, Pudong New District, Shanghai, 200137, China.
    Background: Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) body constitution and serum cytokines, and whether body constitution could independently predict diabetes in IGR subjects. Read More

    Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd).
    BMC Complement Altern Med 2017 Sep 11;17(1):457. Epub 2017 Sep 11.
    Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, -576104, India.
    Background: Tinospora cordifolia (Guduchi or Amrita) is an important drug of Ayurvedic System of Medicine and found mention in various classical texts for the treatment of diseases such as jaundice, fever, diabetes, cancer and skin disease etc. In view of its traditional claims, antioxidant and anti-proliferative activities were evaluated in the present study.

    Methods: Ethanol extract (TCE) and subsequent petroleum ether (TCP), dichloromethane (TCD), n-Butanol (TCB) and aqueous (TCA) fractions of were prepared from stems of T cordifolia. Read More

    Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA).
    BMC Complement Altern Med 2017 Sep 11;17(1):458. Epub 2017 Sep 11.
    Department of Zoology and Aquaculture, Acharya Nagarjuna University, Nagarjuna Nagar 522510, Guntur district, Andhra Pradesh, India.
    Background: The objective of the current study was to assess the in vitro antiplasmodial activities of leaf, bark, flower, and the root of Pongamia pinnata against chloroquine-sensitive Plasmodium falciparum (3D7 strain), cytotoxicity against Brine shrimp larvae and THP-1 cell line. For in vivo study, the plant extract which has shown potent in vitro antimalarial activity was tested against Plasmodium berghei (ANKA strain).

    Methods: The plant Pongamia pinnata was collected from the herbal garden of Acharya Nagarjuna University of Guntur district, Andhra Pradesh, India. Read More

    Modulation of hippocampal neuronal activity by So-ochim-tang-gamibang in mice subjected to chronic restraint stress.
    BMC Complement Altern Med 2017 Sep 9;17(1):456. Epub 2017 Sep 9.
    Department of Neuropsychiatry, Dunsan Korean Medicine Hospital of Daejeon University, Daejeon, 35235, Republic of Korea.
    Background: So-ochim-tang-gamibang (SOCG) is a decoction formula which has been used to improve mental activity in traditional Korean medicine. The present study was performed to evaluate whether the treatment of SOCG was involved in activating hippocampal neurons in mice which were subjected to chronic restraint stress (CRS).

    Methods: Mice were subjected to CRS for 2 weeks to induce depressive-like behaviors. Read More

    Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats.
    BMC Complement Altern Med 2017 Sep 8;17(1):455. Epub 2017 Sep 8.
    Gastroenterology Department, NanLou Clinic, General Hospital of People's Liberation Army, Beijing, 100853, People's Republic of China.
    Background: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of taurine, tea polyphenols (TPs), or a combination thereof, on NASH rats.

    Methods: Rats were divided into a normal group, a high-fat diet induced model group and a treatment group (including taurine, TPs, or taurine + TPs treatment for 8 weeks). Read More

    Radix Puerariae and Fructus Crataegi mixture inhibits renal injury in type 2 diabetes via decreasing of AKT/PI3K.
    BMC Complement Altern Med 2017 Sep 8;17(1):454. Epub 2017 Sep 8.
    Runliang Diabetes Laboratory, Diabetes Research Center, School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo City, 315211, Zhejiang, People's Republic of China.
    Background: Radix puerariae (RP) is a herbal medicines for diabetes, mainly because of anti-oxidative, insulin resistance and hypoglycemic effect. Fructus crataegi (FC) also possesses strong antioxidant activity in vitro. This study focused on the effects of herbal mixture of RP and FC (RPFC) on renal protection through a diabetic rat model. Read More

    Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives?
    BMC Complement Altern Med 2017 Sep 7;17(1):453. Epub 2017 Sep 7.
    Interdepartmental Centre for Industrial Agri-Food Research, University of Bologna, Piazza Goidanich 60, 47521, Cesena, Italy.
    Background: Foodstuffs of both plant and animal origin contain a wide range of bioactive compounds. Although human intervention studies are mandatory to assess the health effects of bioactives, the in vitro approach is often used to select the most promising molecules to be studied in vivo. To avoid misleading results, concentration and chemical form, exposure time, and potential cytotoxicity of the tested bioactives should be carefully set prior to any other experiments. Read More

    Assessing the quality of reports about randomized controlled trials of scalp acupuncture combined with another treatment for stroke.
    BMC Complement Altern Med 2017 Sep 6;17(1):452. Epub 2017 Sep 6.
    Department of Physical & Rehabilitation Medicine, Chonnam National University Medical School and Hospital, Gwangju City, Republic of Korea.
    Background: This study was designed to assess the quality of reporting on randomized controlled trials (RCTs) of scalp acupuncture for the treatment of stroke.

    Methods: The following 8 databases were systematically investigated from their inception to December 2015: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, National Institute of Informatics Scholarly and Academic Information Navigator, National Digital Science Library, Korean Traditional Knowledge Portal, and Korean Studies Information Service System. RCTs utilizing scalp acupuncture as an intervention for stroke were selected, and the quality of reports was assessed based on the Consolidated Standards of Reporting Trials 2010 statement (CONSORT) and Standards for Reporting Interventions in Controlled Trials of Acupuncture 2010 (STRICTA). Read More

    Subchronic toxicity of herbal compound "Jiedu Huayu" granules in rats.
    BMC Complement Altern Med 2017 Sep 6;17(1):450. Epub 2017 Sep 6.
    Department of Liver Disease, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi Province, 530023, China.
    Background: "Jiedu Huayu" (JDHY) granules are traditional Chinese herbal compounds that have been used to treat severe liver injury for many years. The purpose of the current study is to evaluate the safety of JDHY granules.

    Methods: Subchronic toxicity was tested in male and female rats that were orally administered three different doses (80, 100, and 130 g/kg/d) of JDHY for 13 weeks. Read More

    Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb.) water extract prevents DSS-induced colitis in mice by up-regulating type II T helper immune responses.
    BMC Complement Altern Med 2017 Sep 6;17(1):448. Epub 2017 Sep 6.
    Department of Integrative Bioscience and Biotechnology, Institute of Anticancer Medicine Development, Sejong University, Seoul, 143-747, South Korea.
    Background: Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders that are mediated by pathogenic Th1 and Th17 cells. Previous studies have demonstrated that taheebo water extract (TWE) derived from Tabebuia avellanedae Lorentz ex Griseb., as folk remedy, has been used to treat various inflammatory diseases. Read More

    Gypenosides ameliorate memory deficits in MPTP-lesioned mouse model of Parkinson's disease treated with L-DOPA.
    BMC Complement Altern Med 2017 Sep 6;17(1):449. Epub 2017 Sep 6.
    Department of Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju, 28644, Republic of Korea.
    Background: Previous studies have revealed that gypenosides (GPS) improve the symptoms of anxiety disorders in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned rat model of Parkinson's disease (PD). The present study aimed to investigate the effects of GPS on memory deficits in an MPTP-lesioned mouse model of PD treated with L-3,4-dihydroxyphenylalanine (L-DOPA).

    Methods: MPTP (30 mg/kg/day, 5 days)-lesioned mice were treated with GPS (50 mg/kg) and/or L-DOPA (10 and 25 mg/kg) for 21 days. Read More

    A national survey of Chinese medicine doctors and clinical practice guidelines in China.
    BMC Complement Altern Med 2017 Sep 6;17(1):451. Epub 2017 Sep 6.
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Nanxiaojie, Beijing, 100700, China.
    Background: Clinical practice guidelines (CPGs) for Chinese medicine (CM) are being developed to assist doctors with appropriate decisions concerning CM care. To date, there has been little investigation on the perspectives of those to whom the guidelines are directed.

    Methods: A self-administered questionnaire was sent to 4503 doctors in 28 provinces of China in the latter half of 2012. Read More

    Isolation and characterization of the compounds responsible for the antimutagenic activity of Combretum microphyllum (Combretaceae) leaf extracts.
    BMC Complement Altern Med 2017 Sep 6;17(1):446. Epub 2017 Sep 6.
    Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa.
    Background: Mutations play a major role in the pathogenesis and development of several chronic degenerative diseases including cancer. It follows, therefore that antimutagenic compound may inhibit the pathological process resulting from exposure to mutagens. Investigation of the antimutagenic potential of traditional medicinal plants and compounds isolated from plant extracts provides one of the tools that can be used to identify compounds with potential cancer chemopreventive properties. Read More

    Effects of Mollugo pentaphylla extract on monosodium urate crystal-induced gouty arthritis in mice.
    BMC Complement Altern Med 2017 Sep 6;17(1):447. Epub 2017 Sep 6.
    Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, South Korea.
    Background: Gout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in joints and soft tissues, and it can lead to acute or chronic arthritis. MSU are pro-inflammatory stimuli that can initiate, amplify and sustain an intense inflammatory response. In this study, we evaluated the anti-inflammatory effect of an extract of Mollugo pentaphylla (MPE) on MSU-induced gouty arthritis in a mouse model. Read More

    Moon phases and moon signs do not influence morbidity, mortality and long-term survival, after living donor kidney transplantation.
    BMC Complement Altern Med 2017 Sep 4;17(1):440. Epub 2017 Sep 4.
    Department of General-, Visceral-, Vascular- and Transplant Surgery, University of Munich, Marchioninistrasse 15, 81377, Munich, Germany.
    Background: Approximately 11% of the German population are convinced that certain moon phases and moon signs may impact their health and the onset and clinical course of diseases. Before elective surgery, a considerable number of patients look to optimize the timing of the procedure based on the lunar cycle. Especially patients awaiting living donor kidney transplantation (LDKT) commonly look for an adjustment of the date of transplantation according to the moon calendar. Read More

    Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells.
    BMC Complement Altern Med 2017 Sep 5;17(1):445. Epub 2017 Sep 5.
    Department of Medicinal Plant Resources, Andong National University, Andong, 36729, Republic of Korea.
    Background: Although it has been reported to contain high polyphenols, the pharmacological studies of the calyx of Diospyros kaki Thunb (DKC) have not been elucidated in detail. In this study, we elucidated anti-cancer activity and potential molecular mechanism of DKC against human colorectal cancer cells.

    Methods: Anti-cell proliferative effect of 70% ethanol extracts from the calyx of Diospyros kaki (DKC-E70) was evaluated by MTT assay. Read More

    Polarity based characterization of biologically active extracts of Ajuga bracteosa Wall. ex Benth. and RP-HPLC analysis.
    BMC Complement Altern Med 2017 Sep 5;17(1):443. Epub 2017 Sep 5.
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
    Background: The concept of botanical therapeutics has revitalized due to wide importance of plant derived pharmaceuticals. Therefore, the ameliorative characteristics of Ajuga bracteosa were studied.

    Methods: Total phenolic content, flavonoid content, antioxidant capacity, reducing power and free-radical scavenging activity were determined colorimetrically. Read More

    A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial.
    BMC Complement Altern Med 2017 Sep 4;17(1):441. Epub 2017 Sep 4.
    ProDigest, Technologiepark 3, 9052, Ghent, Belgium.
    Background: Constipation and symptoms of gastrointestinal discomfort such as bloating are common among otherwise healthy individuals, but with significant impact on quality of life. Despite the recognized contribution of the gut microbiome to this pathology, little is known about which group(s) of microorganism(s) are playing a role. A previous study performed in vitro suggests that EpiCor® fermentate has prebiotic-like properties, being able to favorably modulate the composition of the gut microbiome. Read More

    Agrimonia pilosa Ledeb. aqueous extract improves impaired glucose tolerance in high-fat diet-fed rats by decreasing the inflammatory response.
    BMC Complement Altern Med 2017 Sep 5;17(1):442. Epub 2017 Sep 5.
    Division of Applied Food System, Major of Food and Nutrition, Seoul Women's University, Seoul, 01797, South Korea.
    Background: Agrimonia pilosa Ledeb. is a medicinal plant with physiological activities such as anti-cancer, antioxidant, anti-inflammatory activities and in vitro anti-diabetic activity. However, the effects of aqueous extracts from A. Read More

    Will Chinese external therapy with compound Tripterygium wilfordii hook F gel safely control disease activity in patients with rheumatoid arthritis: design of a double-blinded randomized controlled trial.
    BMC Complement Altern Med 2017 Sep 5;17(1):444. Epub 2017 Sep 5.
    Rheumatism Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange Street, Xicheng District, Beijing, 100053, China.
    Background: Chinese external therapy (CET) is a topical application with mainly Chinese herb medicine therapy with thousands of years of historical implications and is a clinical routine that is commonly used for relieving joint-related symptoms in patients with arthritis in Chinese hospitals. However, there is a paucity of modern medical evidence to support its effectiveness and safety. Thus, we propose to implement a randomized, double-blinded, placebo-controlled clinical trial in patients with rheumatoid arthritis (RA) using, as the experimental intervention, topical application of a hospital-compounded gel preparation of Tripterygium wilfordii Hook F (TwHF). Read More

    Sasang constitutional types for the risk prediction of metabolic syndrome: a 14-year longitudinal prospective cohort study.
    BMC Complement Altern Med 2017 Sep 2;17(1):438. Epub 2017 Sep 2.
    Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
    Background: To examine whether the use of Sasang constitutional (SC) types, such as Tae-yang (TY), Tae-eum (TE), So-yang (SY), and So-eum (SE) types, increases the accuracy of risk prediction for metabolic syndrome.

    Methods: From 2001 to 2014, 3529 individuals aged 40 to 69 years participated in a longitudinal prospective cohort. The Cox proportional hazard model was utilized to predict the risk of developing metabolic syndrome. Read More

    Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis.
    BMC Complement Altern Med 2017 Sep 2;17(1):439. Epub 2017 Sep 2.
    Janssen Research & Development, LLC, Spring House, PA, USA.
    Background: Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as a therapy for several inflammatory conditions, including psoriasis. However, its mechanism is unknown due to lack of knowledge about the responsible chemical entity. We took a different approach to this challenge by investigating the molecular profile of Indigo naturalis treatment and impacted pathways. Read More

    Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs.
    BMC Complement Altern Med 2017 Aug 31;17(1):436. Epub 2017 Aug 31.
    Laboratory of Anatomy, School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 Yu Quan Road, Nankai District, Tianjin, 300193, China.
    Background: Primary dysmenorrhoea (PD), defined as painful menses in women with normal pelvic anatomy, is one of the most common gynaecological syndromes. Acupoint-stimulation could potentially be an effective intervention for PD. Our aim was to determine the effectiveness of acupoint-stimulation compared with Non-Steroidal Anti-Inflammatory Drugs (NASIDs) in the treatment of PD. Read More

    Should DNA sequence be incorporated with other taxonomical data for routine identifying of plant species?
    BMC Complement Altern Med 2017 Aug 31;17(1):437. Epub 2017 Aug 31.
    Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand.
    Background: A variety of plants in Acanthaceae have long been used in traditional Thai ailment and commercialised with significant economic value. Nowadays medicinal plants are sold in processed forms and thus morphological authentication is almost impossible. Full identification requires comparison of the specimen with some authoritative sources, such as a full and accurate description and verification of the species deposited in herbarium. Read More

    Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia.
    BMC Complement Altern Med 2017 Aug 30;17(1):432. Epub 2017 Aug 30.
    Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
    Background: Recent reports have demonstrated that impaired barrier function and local microinflammation in the duodenal mucosa contribute to the pathogeneses of functional dyspepsia (FD). Thus, restoring normal barrier integrity becomes a potential therapeutic strategy in the treatment of FD. Sini-San (SNS) is a traditional Chinese prescription that exhibits therapeutic effects in FD, but the underlying mechanisms remain not well understood. Read More

    Evaluation of Rumex hastatus leaves against hepatic fibrosis: a rat model.
    BMC Complement Altern Med 2017 Aug 30;17(1):435. Epub 2017 Aug 30.
    Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, Islamabad, Pakistan.
    Background: Rumex hastatus leaves have been widely used as food additive and for the treatment of various liver ailments. According to our previous studies, ethyle acetate (ERL) and methanolic (MRL) fractions of R. hastatus leaves are an accessible source of natural antioxidants. Read More

    A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study.
    BMC Complement Altern Med 2017 Aug 30;17(1):433. Epub 2017 Aug 30.
    Centre d'Evaluation et de Traitement de la Douleur, service de neurochirurgie, Hôpital Salengro, CHRU de Lille, 59037, Lille Cedex, France.
    Background: Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig®, PiLeJe) was investigated in an observational study. Read More

    Flavonoids from Tetracera indica Merr. induce adipogenesis and exert glucose uptake activities in 3T3-L1 adipocyte cells.
    BMC Complement Altern Med 2017 Aug 30;17(1):431. Epub 2017 Aug 30.
    Halal Institute Research Institute, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
    Background: Tetracera indica Merr. (Family: Dilleniaceae), known to the Malay as 'Mempelas paya', is one of the medicinal plants used in the treatment of diabetes in Malaysia. However, no proper scientific study has been carried out to verify the traditional claim of T. Read More

    Traditional healer treatment of HIV persists in the era of ART: a mixed methods study from rural South Africa.
    BMC Complement Altern Med 2017 Aug 30;17(1):434. Epub 2017 Aug 30.
    MRC/Wits Agincourt Research Unit, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
    Background: Human immunodeficiency virus (HIV) substantially contributes to the burden of disease and health care provision in sub-Saharan Africa, where traditional healers play a major role in care, due to both their accessibility and acceptability. In rural, northeastern South Africa, people living with HIV often ping-pong between traditional healers and allopathic providers.

    Methods: We conducted 27 in-depth interviews and 133 surveys with a random sample of traditional healers living in Bushbuckridge, South Africa, where anti-retroviral therapy (ART) is publicly available, to learn: (1) healer perspectives about which HIV patients they choose to treat; (2) the type of treatment offered; (3) outcomes expected, and; (4) the cost of delivering treatment. Read More

    Survey of integrative lumbar spinal stenosis treatment in Korean medicine doctors: preliminary data for clinical practice guidelines.
    BMC Complement Altern Med 2017 Aug 29;17(1):425. Epub 2017 Aug 29.
    Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, 858 Eonju-ro, Gangnam-gu, Seoul, Republic of Korea.
    Background: Considering that large variations exist amongst practitioners in lumbar disorder management and the significant costs that lumbar disorders incur, determining clinical practice patterns to provide preliminary data for standardization should be given higher priority. Lumbar spinal stenosis (LSS) is commonly treated using integrative non-surgical methods by Korean medicine doctors (KMDs) in Korea, and this is the first study to assess current Korean medicine practice trends for LSS.

    Methods: A survey on KMD diagnosis, treatment, prognosis and decision-making in LSS treatment was developed in a 3-step procedure of preliminary drafting, revision based on extramural expert opinion, and final editing. Read More

    Community pharmacists' knowledge, practices and beliefs about complementary and alternative medicine in Palestine: a cross-sectional study.
    BMC Complement Altern Med 2017 Aug 29;17(1):429. Epub 2017 Aug 29.
    Palestine Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
    Background: Complementary and alternative medicine (CAM) utilization is dramatically increasing among patients. As community pharmacies are a major provider of CAM products, community pharmacists need to have the sufficient knowledge and information to advice their patients, answer their inquiries and to be proactive in the healthcare process to ensure optimal therapy outputs and minimize both drug-drug and drug-herb interactions. Therefore, the main objective of this study was to assess the knowledge, beliefs, and practices of community pharmacists in Palestine about CAM. Read More

    Preventive effects of the novel antimicrobial peptide Nal-P-113 in a rat Periodontitis model by limiting the growth of Porphyromonas gingivalis and modulating IL-1β and TNF-α production.
    BMC Complement Altern Med 2017 Aug 29;17(1):426. Epub 2017 Aug 29.
    Department of Periodontics and Oral Biology, School of Stomatology, China Medical University, Shenyang, 110002, China.
    Background: P-113 (AKRHHGYKRKFH-NH2) is a 12-amino-acid histidine-rich peptide derived from histatin 5 that is highly degradable in high salt concentrations and biological fluids such as serum, plasma and saliva. Nal-P-113, a novel antimicrobial peptide whose histidine residues are replaced by the bulky amino acids β-naphthylalanine, causes the antimicrobial peptide to retain its bactericidal activity even in physiological environments. This study evaluated the effect of the novel antimicrobial peptide Nal-P-113 in a rat periodontitis model and the mechanisms of action of Nal-P-113 for suppressing periodontitis. Read More

    The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study.
    BMC Complement Altern Med 2017 Aug 29;17(1):427. Epub 2017 Aug 29.
    Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, 91 Hsueh-Shih Rd. North District, Taichung, 404, Taiwan.
    Background: Many patients with gynecological disorders seek traditional medicine consultations in Asian countries. This study intended to investigate the utilization of traditional Chinese medicine (TCM) in patients with dysfunctional uterine bleeding (DUB) in Taiwan.

    Methods: We analyzed a cohort of one million individuals randomly selected from the National Health Insurance Research Database in Taiwan. Read More

    Inhibition of human cytomegalovirus immediate-early gene expression and replication by the ethyl acetate (EtOAc) fraction of Elaeocarpus sylvestris in vitro.
    BMC Complement Altern Med 2017 Aug 29;17(1):428. Epub 2017 Aug 29.
    Department of Life Science, Gachon University, Seongnam-Si, Gyeonggi-Do, 13120, South Korea.
    Background: In immunocompromised patients, human cytomegalovirus (HCMV) infection can lead to severe, life-threatening diseases, such as pneumonitis, hepatitis, gastrointestinal tract disease, and retinitis. We previously reported that a 70% ethanol extract of Elaeocarpus sylvestris leaves (ESE) inhibits human cytomegalovirus (HCMV) replication in vitro. In the present study, we determined the solvent fraction of ESE that inhibits HCMV replication using activity-guided fractionation. Read More

    GS-E3D, a new pectin lyase-modified red ginseng extract, inhibited diabetes-related renal dysfunction in streptozotocin-induced diabetic rats.
    BMC Complement Altern Med 2017 Aug 29;17(1):430. Epub 2017 Aug 29.
    Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseongdaero, Yuseong-gu, Daejeon, 34054, South Korea.
    Background: GS-E3D is a newly developed pectin lyase-modified red ginseng extract. The purpose of this study was to investigate the therapeutic effects of GS-E3D on diabetes-related renal dysfunction in streptozotocin-induced diabetic rats.

    Method: GS-E3D (25, 50, and 100 mg/kg body weight per day) was administered for 6 weeks. Read More

    Yang-warming method in the treatment of diabetic peripheral neuropathy: an updated systematic review and meta-analysis.
    BMC Complement Altern Med 2017 Aug 25;17(1):424. Epub 2017 Aug 25.
    Department of Chronic Disease, Liaoning University of Traditional Chinese Medicine, Chongshan East Road No.72, Shenyang, Liaoning, 110032, China.
    Background: Various studies have suggested the effectiveness of Chinese medicine in the treatment of diabetic peripheral neuropathy (DPN). There are several principles and methods in Chinese medicine for the treatment of DPN and yang-warming method is one of them. The purpose of this meta-analysis was to review the effectiveness and safety of yang-warming method using yang-warming Chinese medicine (YCM) in the treatment of DPN. Read More

    Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats.
    BMC Complement Altern Med 2017 Aug 24;17(1):423. Epub 2017 Aug 24.
    Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh.
    Background: Euphorbia hirta linn., is a species of Euphorbiaceae family. They are known as asthma plant, barokhervi. Read More

    Etlingera elatior Extract promotes cell death in B16 melanoma cells via down-regulation of ERK and Akt signaling pathways.
    BMC Complement Altern Med 2017 Aug 22;17(1):415. Epub 2017 Aug 22.
    Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.
    Background: Torch ginger (Etlingera elatior, EE) is a ginger plant that found in Southeast Asia. Previous study showed its flowers and leaves composed of several flavonoids with anti-cancer activity. This study aims to investigate the mechanism of EE extract on cell death induction in melanoma cells. Read More

    Wrist-ankle acupuncture (WAA) for primary dysmenorrhea (PD) of young females: study protocol for a randomized controlled trial.
    BMC Complement Altern Med 2017 Aug 22;17(1):421. Epub 2017 Aug 22.
    Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, 168 Changhai Road, Yangpu District, Shanghai, China.
    Background: Primary dysmenorrhea (PD) is one of the most common health complaints all over the world, specifically among young females. Acupuncture has been employed to relieve the pain-based symptoms and to avoid the side effects of conventional medication, and wrist-ankle acupuncture (WAA) has confirmed analgesic efficacy for various types of pain. The aim of this study is to evaluate the immediate analgesia effect of WAA on PD of young females. Read More

    In vivo evaluation of hot water extract of Acorus gramineus root against benign prostatic hyperplasia.
    BMC Complement Altern Med 2017 Aug 22;17(1):414. Epub 2017 Aug 22.
    Food Research Center, Jeonnam Bio-industry Foundation, 30-5 Dongsunonggongdanji-gil, Naju-si, Jeollanam-do, 58275, Republic of Korea.
    Background: Acorus gramineus has been reported to exhibit various pharmacological effects including inhibition of cholesterol synthesis, enhancement of lipid metabolism, prevention of dementia and inhibition of mast cell growth. According to the Chinese compendium of materia media, it has been reported that Acorus spp. is effective for sedation, dementia prevention as well as diuretic effect. Read More

    A randomized double-blind placebo-controlled trial to investigate the effectiveness and safety of a novel green-lipped mussel extract -BioLex® -for managing pain in moderate to severe osteoarthritis of the hip and knee.
    BMC Complement Altern Med 2017 Aug 22;17(1):416. Epub 2017 Aug 22.
    Seperex Nutritionals, The Centre for Innovation, Dunedin, New Zealand.
    Background: Extracts from perna canaliculus, the Green Lipped Mussel (GLM) are widely used as a complimentary therapy by patients with osteoarthritis (OA). The current study investigated the potential of a novel GLM formulation as a treatment for OA. A randomized double-blind placebo-controlled trial was undertaken to assess potential impacts on pain and quality of life following 12 weeks of treatment. Read More

    Chemical composition and evaluation of the antibacterial and Cytotoxic activities of the essential oil from the leaves of Myracrodruon urundeuva.
    BMC Complement Altern Med 2017 Aug 22;17(1):419. Epub 2017 Aug 22.
    Centro de Biociências (CB), Departamento de Microbiologia e Parasitologia, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, 59072-970, Brazil.
    Background: This study evaluated the in vitro activity of essential oil extracted from the leaves of Myracrodruon urundeuva.

    Methods: The oil was obtained by hydro-distillation and characterized by Gas Chromatography coupled to Mass Spectrometry (GC-MS) and Gas Chromatography with Flame Ionization Detector (GC-FID). The antibacterial activity was evaluated by the broth microdilution technique and the MIF was determined by using growth indicator CTT (2,3,5-triphenyl-tetrazolium) and CBM in BHI agar. Read More

    Prevalence, patterns, and perceived value of complementary and alternative medicine among HIV patients: a descriptive study.
    BMC Complement Altern Med 2017 Aug 23;17(1):422. Epub 2017 Aug 23.
    School of Medicine and Arthur Lok Jack Graduate School of Business, University of the West Indies, St. Augustine, Trinidad and Tobago.
    Background: Use of complementary and alternative medicine (CAM) is widespread among different patient populations despite the availability of evidence-based conventional medicine and lack of supporting evidence for the claims of most CAM types. This study explored the prevalence, patterns, and perceived value of CAM among human immunodeficiency virus (HIV) patients.

    Methods: This quantitative descriptive study was conducted between November 1, 2014 and March 31, 2015 among a cross-sectional, convenience sample of attendees of the HIV clinic of a public tertiary health care institution. Read More

    Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats.
    BMC Complement Altern Med 2017 Aug 22;17(1):418. Epub 2017 Aug 22.
    Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University (KAU), PO BOX 80216, Jeddah, 21589, Kingdom of Saudi Arabia.
    Background: Hepatocellular carcinoma (HCC) accounts for major cancer-related deaths despite current advanced therapies. Treatment and prognosis of HCC is better in patients with preserved liver function. Many natural products including ajwa dates (Phoenix dactylifera L. Read More

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