3,566 results match your criteria BMC Complementary and Alternative Medicine [Journal]


Multi-targeting chemoprevention of Chinese herb formula Yanghe Huayan decoction on experimentally induced mammary tumorigenesis.

BMC Complement Altern Med 2019 Feb 13;19(1):48. Epub 2019 Feb 13.

Affiliated Hospital of Taishan Medical University, Taian, 271000, Shandong, China.

Background: Development of safe and effective chemopreventive agents is a winning strategy in reducing the morbidity and mortality of breast cancer. The current study was to investigate the mechanism-based chemopreventive potential of a Chinese herb formula Yanghe Huayan (YHHY) Decoction on the classical 7,12-dimethylbenz(a)anthracene (DMBA) induced rat mammary carcinogenesis model.

Methods: Female Sprague-Dawley rats at 42 days of age were orally administered with a human equivalent dose of YHHY Decoction at 0. Read More

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http://dx.doi.org/10.1186/s12906-019-2456-1DOI Listing
February 2019

Potential in vitro anti-allergic, anti-inflammatory and cytotoxic activities of ethanolic extract of Baliospermum montanum root, its major components and a validated HPLC method.

BMC Complement Altern Med 2019 Feb 12;19(1):45. Epub 2019 Feb 12.

Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani, 12120, Thailand.

Background: The root of Baliospermum montanum has been used as an ingredient of traditional Thai medicines for the treatments of several diseases including itching eczema, muscle and joint inflammation, and cancer. Few studies have been done on phytochemical components of this root. In this study, we isolated major compounds of the crude ethanolic extract of B. Read More

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http://dx.doi.org/10.1186/s12906-019-2449-0DOI Listing
February 2019
1 Read

Crude extract from Libidibia ferrea (Mart. ex. Tul.) L.P. Queiroz leaves decreased intra articular inflammation induced by zymosan in rats.

BMC Complement Altern Med 2019 Feb 12;19(1):47. Epub 2019 Feb 12.

Post Graduation in Biological Science/Post graduation program in Pharmaceutical Science/Department of Biophysics and Pharmacology, UFRN, Natal, RN, Brazil.

Background: Libidibia ferrea (L. ferrea) has been used in folk medicine to treat several conditions and to prevent cancer. This study performed a chromatographic analysis of the crude aqueous extract of Libidibia ferrea (Mart. Read More

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http://dx.doi.org/10.1186/s12906-019-2454-3DOI Listing
February 2019

Improved antibacterial effects of alkali-transformed saponin from quinoa husks against halitosis-related bacteria.

BMC Complement Altern Med 2019 Feb 12;19(1):46. Epub 2019 Feb 12.

Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Background: Quinoa is a food crop native to the Andes. The process of dehulling quinoa can produce approximately 8-12% husk, which is often discarded because it contains bitter saponin. Saponin derived from quinoa has been reported to exhibit anti-inflammatory and antifungal activity. Read More

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http://dx.doi.org/10.1186/s12906-019-2455-2DOI Listing
February 2019

Effect of freeze-dried Carica papaya leaf juice on inflammatory cytokines production during dengue virus infection in AG129 mice.

BMC Complement Altern Med 2019 Feb 11;19(1):44. Epub 2019 Feb 11.

Herbal Medicine Research Center, Institute for Medical Research, Ministry of Health Malaysia, 50588, Kuala Lumpur, Malaysia.

Background: Carica papaya leaves have been used for traditional treatment of dengue fever and have been reported to exhibit an immunomodulatory activity by affecting the level of cytokine production in vitro and in vivo. Due to the lack of adequate in vivo evidence in dengue disease model, the present study was initiated to screen and identify the cytokines affected by freeze-dried C. papaya leaf juice (FCPLJ) treatment in AG129 mice infected with DEN-2 dengue virus. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2438-3DOI Listing
February 2019
2 Reads

Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells.

BMC Complement Altern Med 2019 Feb 8;19(1):43. Epub 2019 Feb 8.

Department of Medicinal Plant Resources, Andong National University, 1375 Gyeongdong-ro, Andong, Gyeongsangbuk-do, 36729, Republic of Korea.

Background: Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. Read More

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http://dx.doi.org/10.1186/s12906-019-2453-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368743PMC
February 2019
1 Read

Decreased fracture incidence with traditional Chinese medicine therapy in patients with osteoporosis: a nationwide population-based cohort study.

BMC Complement Altern Med 2019 Feb 4;19(1):42. Epub 2019 Feb 4.

Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan.

Background: There are no published studies regarding the efficacy of traditional Chinese medicine (TCM) for the prevention of osteoporotic fracture. Therefore, we conducted this nationwide, population-based cohort study to investigate the probable effect of TCM to decrease the fracture rate.

Methods: We identified cases with osteoporosis and selected a comparison group that was frequency-matched according to sex, age (per 5 years), diagnosis year of osteoporosis, and index year. Read More

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http://dx.doi.org/10.1186/s12906-019-2446-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360787PMC
February 2019
1 Read

Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease.

BMC Complement Altern Med 2019 Feb 4;19(1):39. Epub 2019 Feb 4.

Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA.

Background: Alzheimer's disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. Read More

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http://dx.doi.org/10.1186/s12906-019-2451-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360737PMC
February 2019
1 Read

Anti-borreliae efficacy of selected organic oils and fatty acids.

BMC Complement Altern Med 2019 Feb 4;19(1):40. Epub 2019 Feb 4.

Department of Infectious Diseases, Dr. Rath Research Institute, 1260 Memorex Dr., Santa Clara, CA, 95050, USA.

Background: Borrelia sp. is a causative pathogen of Lyme disease which has become a worldwide health concern. Non-toxic approaches especially directed toward latent persistent forms of this pathogen are desired. Read More

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http://dx.doi.org/10.1186/s12906-019-2450-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360722PMC
February 2019
1 Read

Effects of Radix Linderae extracts on a mouse model of diabetic bladder dysfunction in later decompensated phase.

BMC Complement Altern Med 2019 Feb 4;19(1):41. Epub 2019 Feb 4.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, China.

Background: This study aimed to elucidate the effects and mechanisms of Radix Linderae (RL) extracts on a mouse model of diabetic bladder dysfunction (DBD), especially on later decompensated phase.

Methods: Male C57BL/6J mice were intraperitoneally injected with streptozotocin (STZ) after 4 weeks of high-fat diet (HFD) feeding. DBD mouse models (later decompensated phase) were developed by 12-weeks persistent hyperglycemia and then treated with RL extracts for 4 weeks. Read More

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http://dx.doi.org/10.1186/s12906-019-2448-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360732PMC
February 2019
1 Read

Antilisterial efficacy of Lactobacillus brevis MF179529 from cow: an in vivo evidence.

BMC Complement Altern Med 2019 Feb 1;19(1):37. Epub 2019 Feb 1.

Department of Zoology, University of the Punjab , Quaid-i-Azam Campus, Lahore, Pakistan.

Background: Listeria monocytogenes is an opportunistic foodborne pathogen that causes human Listeriosis and high mortality particularly in immunocompromised individuals. Pregnant women are more prone to L. monocytogenes infection resulting in abortions. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2444-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359795PMC
February 2019
2 Reads

2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells.

BMC Complement Altern Med 2019 Feb 1;19(1):38. Epub 2019 Feb 1.

Ministry of Education Key Laboratory of Chinese Medicinal Resource from Lingnan, Research Center of Medicinal Plant Resource Science and Engineering, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Higher Education Mega Center, Guangzhou, 510006, China.

Background: Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding cancer stemness of HCC CSCs, which are essential for hepatoma initiation, relapse, metastasis and drug resistance. Therefore, STAT3 has been validated as a novel anti-cancer drug target and the strategies targeting HCC CSCs may bring new hopes to HCC therapy. Read More

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http://dx.doi.org/10.1186/s12906-019-2440-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359800PMC
February 2019
1 Read

Effect of Osteoking on the osteogenic and adipogenic differentiation potential of rat bone marrow mesenchymal stem cells in vitro.

BMC Complement Altern Med 2019 Jan 31;19(1):36. Epub 2019 Jan 31.

Yunnan Key laboratory for Basic Research on Bone and Joint Diseases, Kunming University, Kunming, 650214, China.

Background: Bone damage is a condition that affects the quality of life of patients. Mesenchymal stem cells (MSCs) are important for bone repair. Osteoking is a natural compound in traditional Chinese Medicine used to treat bone diseases; however, the effect of Osteoking on the differentiation of MSCs has not been reported. Read More

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http://dx.doi.org/10.1186/s12906-019-2435-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357478PMC
January 2019
1 Read

Wu-Mei-wan protects pancreatic β cells by inhibiting NLRP3 Inflammasome activation in diabetic mice.

BMC Complement Altern Med 2019 Jan 31;19(1):35. Epub 2019 Jan 31.

Department of Integrative Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: Wu-Mei-Wan (WMW) is a traditional Chinese herbal formulation that is clinically prescribed to treat diabetes mellitus in China. WMW has been shown to alleviate damage in pancreatic β cells, but the underlying mechanism remains unclear. This study aims to explore how WMW plays a protective role in pancreatic islets. Read More

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http://dx.doi.org/10.1186/s12906-019-2443-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357370PMC
January 2019

The activity of commercial antimicrobials, and essential oils and ethanolic extracts of Olea europaea on Streptococcus agalactiae isolated from pregnant women.

BMC Complement Altern Med 2019 Jan 30;19(1):34. Epub 2019 Jan 30.

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Private Bag X1314, Alice, Eastern Cape Province, 5700, South Africa.

Background: Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a major cause of disease in pregnant women and new born babies where it causes early and late onset disease characterised by sepsis, pneumonia and meningitis. Ten to 37 % of pregnant women in the world are colonised with GBS while intrapartum antibiotic prophylaxis has led to significant reduction in early onset disease. The increase in drug resistant microorganisms has become a major threat. Read More

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http://dx.doi.org/10.1186/s12906-019-2445-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354339PMC
January 2019
3 Reads

Bioassay-guided isolation of active anti-adipogenic compound from royal jelly and the study of possible mechanisms.

BMC Complement Altern Med 2019 Jan 29;19(1):33. Epub 2019 Jan 29.

Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Sinyong-Dong, Iksan, 570-749, South Korea.

Background: Royal jelly (RJ) has been used traditionally for dietary, cosmetic and health purposes for a long time in different parts of the world. Scientific studies have also shown its numerous health-promoting properties including hypoglycemic and anti-hypercholesterolemic action. In this study, we investigated the anti-adipogenic activity of RJ in 3 T3-L1 cells and isolated the major responsible root component for the activity. Read More

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http://dx.doi.org/10.1186/s12906-018-2423-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352437PMC
January 2019
2 Reads

The anti-proliferative effect of apricot and peach kernel extracts on human colon cancer cells in vitro.

BMC Complement Altern Med 2019 Jan 29;19(1):32. Epub 2019 Jan 29.

Department of Medical Biosciences, University of the Western Cape, Robert Sobukwe road, PO Box x17, Cape Town, Bellville, 7535, South Africa.

Background: Colorectal malignant neoplasms is one of the leading causes of death in both men and women in the developed world and the incidence has recently increased markedly in South Africa. Studies have highlighted the beneficial effects of Amygdalin, a cyanogenic compound found in both peach and apricot kernels, in its ability to suppress the development of colon cancer. The focus of this study was to investigate the potential anti-proliferative properties of various apricot and peach kernels extractions from South Africa and China and to monitor alterations in cell cycle kinetics in colon cancer cells. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2437-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352493PMC
January 2019
2 Reads

Protective effects of Camellia japonica flower extract against urban air pollutants.

BMC Complement Altern Med 2019 Jan 28;19(1):30. Epub 2019 Jan 28.

Biospectrum Life Science Institute, A-1805, U-TOWER, 767, Sinsu-ro, Suji-gu, Yongin-si, Gyeonggi-do, 16827, Republic of Korea.

Background: Exposure of skin to urban air pollutants is closely related to skin aging and inflammatory responses such as wrinkles formation, pigmentation spot, atopic dermatitis, and acne. Thus, a great deal of interest has been focused on the development of natural resources that can provide a protective effect to skin from pollutants.

Methods: The antioxidative activity of Camellia japonica flower extract (CJFE) was evaluated by 1,2-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) assay, and the inhibitory effect of CJFE by urban air pollutants-induced reactive oxygen species (ROS) production was determined in cultured normal human dermal fibroblasts (NHDFs). Read More

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http://dx.doi.org/10.1186/s12906-018-2405-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350298PMC
January 2019

An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten.

BMC Complement Altern Med 2019 Jan 28;19(1):31. Epub 2019 Jan 28.

Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul, 02841, Republic of Korea.

Background: Opuntia ficus-indica var. saboten (OFIS) is used widely in Korea to treat constipation due to its diuretic effects and its enhancement of bowel function and appetite. However, its safety has not yet been established. Read More

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http://dx.doi.org/10.1186/s12906-019-2442-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350306PMC
January 2019
2 Reads
2.020 Impact Factor

Critical pharmacokinetic and pharmacodynamic drug-herb interactions in rats between warfarin and pomegranate peel or guava leaves extracts.

BMC Complement Altern Med 2019 Jan 24;19(1):29. Epub 2019 Jan 24.

Department of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Airport Road, P.O. Box 961343, Amman, Jordan.

Background: In-depth information of potential drug-herb interactions between warfarin and herbal compounds with suspected anticoagulant blood thinning effects is needed to raise caution of concomitant administration. The current study aimed to investigate the impact of co-administration of pomegranate peel and guava leaves extracts, including their quality markers namely; ellagic acid and quercetin, respectively, on warfarin's in vivo dynamic activity and pharmacokinetic actions, in addition to potential in vitro cytochrome P450 enzymes (CYP) inhibition.

Methods: Influence of mentioned extracts and their key constituents on warfarin pharmacodynamic and kinetic actions and CYP activity were evaluated. Read More

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http://dx.doi.org/10.1186/s12906-019-2436-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344987PMC
January 2019
1 Read

Twelve Chinese herbal preparations for the treatment of depression or depressive symptoms in cancer patients: a systematic review and meta-analysis of randomized controlled trials.

BMC Complement Altern Med 2019 Jan 23;19(1):28. Epub 2019 Jan 23.

School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.

Background: Patients with cancer are vulnerable to depression or other depressive conditions. The aim of this paper was to evaluate the efficacy and safety of Chinese herbal medicine (CHM) for the treatment of depression or depressive symptoms in cancer patients.

Methods: CENTRAL, MEDLINE, EMBASE, PsycINFO, CNKI, VIP, SinoMed, and online clinical trial registry websites were searched for relevant RCTs until May 2017. Read More

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http://dx.doi.org/10.1186/s12906-019-2441-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345004PMC
January 2019
1 Read

Correction to: Perceptions of traditional Chinese medicine for chronic disease care and prevention: a cross-sectional study of Chinese hospital-based health care professionals.

BMC Complement Altern Med 2019 01 22;19(1):26. Epub 2019 Jan 22.

Faculty of Human Sciences, Waseda University, 1-104 Totsukamachi, Shinjuku-ku, Tokyo, 169-8050, Japan.

Following publication of the original article [1], the author reported that the funding information was missing from the original article. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2434-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341565PMC
January 2019
2 Reads

A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia.

BMC Complement Altern Med 2019 Jan 22;19(1):27. Epub 2019 Jan 22.

Center for Gastrointestinal Research, Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, 3410 Worth Street, Suite 610, Dallas, TX, 75246, USA.

Background: Dyslipidemia is one of the most frequently implicated risk factors for development of atherosclerosis. This study evaluated the efficacy of amla (Emblica officinalis) extract (composed of polyphenols, triterpenoids, oils etc. as found in the fresh wild amla fruit) in patients with dyslipidemia. Read More

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http://dx.doi.org/10.1186/s12906-019-2430-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341673PMC
January 2019

Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro.

BMC Complement Altern Med 2019 Jan 18;19(1):23. Epub 2019 Jan 18.

Society for Cancer Research, Hiscia Institute, Arlesheim, Switzerland.

Background: Women diagnosed with breast cancer frequently seek complementary and alternative (CAM) treatment options that can help to cope with their disease and the side effects of conventional cancer therapy. Especially in Europe, breast cancer patients use herbal products containing mistletoe (Viscum album L.). Read More

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http://dx.doi.org/10.1186/s12906-019-2439-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339413PMC
January 2019
3 Reads

Combined antibacterial effect of essential oils from three most commonly used Ethiopian traditional medicinal plants on multidrug resistant bacteria.

BMC Complement Altern Med 2019 Jan 18;19(1):24. Epub 2019 Jan 18.

Salale University, Fiche Campus, Addis Ababa, Ethiopia.

Background: An alarm increase the rate of emerging and re-emerging of multidrug resistant bacteria have been caused great public health concern in the worldwide. They have been resisting for most or majority of currently available and affordable antibiotics and imposed socioeconomic catastrophe at global scale. As a result, there is utmost important to discover new or modify currently available antibiotics. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2429-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339401PMC
January 2019
12 Reads

Preventive effects of a novel herbal mixture on atopic dermatitis-like skin lesions in BALB/C mice.

BMC Complement Altern Med 2019 Jan 18;19(1):25. Epub 2019 Jan 18.

Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics (LVPP), College of Veterinary Medicine, Kyungpook National University, 41566, 80 Daehakro, Bukgu, Daegu, Republic of Korea.

Background: A combination of parts of Cornus officinalis, Rosa multiflora, Lespedeza bicolor, Platycladus orientalis, and Castanea crenata is commonly used for alleviating inflammatory skin disorders. Therefore, this study was carried out to evaluate the in vitro and in vivo preventive effects of a novel herbal formula made from the five plants (C2RLP) against atopic dermatitis in BALB/C mice.

Methods: Mice were allocated into five groups (n = 8) including, control (Normal, petrolatum, and betamethasone treated) and treatment groups (treated with 2. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2426-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339437PMC
January 2019
4 Reads

Improvement of diabetic wound healing by topical application of Vicenin-2 hydrocolloid film on Sprague Dawley rats.

BMC Complement Altern Med 2019 Jan 17;19(1):20. Epub 2019 Jan 17.

Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Background: Impaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. The risk of developing diabetic foot ulcers for diabetic patients is 15% over their lifetime and approximately 85% of limb amputations is caused by non-healing ulcers. Unhealed, gangrenous wounds destroy the structural integrity of the skin, which acts as a protective barrier that prevents the invasion of external noxious agents into the body. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2427-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337851PMC
January 2019
8 Reads

Validation of the anti-infective potential of a polyherbal 'Panchvalkal' preparation, and elucidation of the molecular basis underlining its efficacy against Pseudomonas aeruginosa.

BMC Complement Altern Med 2019 Jan 17;19(1):19. Epub 2019 Jan 17.

Institute of Science, Nirma University, Ahmedabad, 382481, India.

Background: A Panchvalkal formulation (Pentaphyte P-5®) mentioned in ancient texts of Indian traditional medicine was investigated for its anti-infective potential against Pseudomonas aeruginosa.

Methods: Effect of the test formulation on bacterial growth and pigment production was evaluated by broth dilution assay. In vivo efficacy was evaluated using Caenorhabditis elegans as the model host. Read More

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http://dx.doi.org/10.1186/s12906-019-2428-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335721PMC
January 2019
1 Read

The effectiveness of self-care and lifestyle interventions in primary dysmenorrhea: a systematic review and meta-analysis.

BMC Complement Altern Med 2019 Jan 17;19(1):22. Epub 2019 Jan 17.

School of Science and Health, Western Sydney University, Sydney, Australia.

Background: Menstrual pain is very common amongst young women. Despite the significant impact that menstrual pain has on academic attendance and performance, social activities and quality of life, most young women do not seek medical treatment but prefer to use self-care; commonly OTC analgesic medications and rest. Many women do not get significant pain relief from these methods, therefore other low cost, easy to learn self-care methods may be a valuable approach to management. Read More

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http://dx.doi.org/10.1186/s12906-019-2433-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337810PMC
January 2019
2 Reads

The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data.

BMC Complement Altern Med 2019 Jan 17;19(1):21. Epub 2019 Jan 17.

The Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.

Background: Peppermint oil (PO) has intrinsic properties that may benefit patients with irritable bowel syndrome (IBS) symptoms. The study objective was to determine the effect of peppermint oil in the treatment of the IBS.

Methods: We systematically searched MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (Cochrane CENTRAL), ClinicalTrials. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337770PMC
January 2019
5 Reads

Self-management strategies amongst Australian women with endometriosis: a national online survey.

BMC Complement Altern Med 2019 Jan 15;19(1):17. Epub 2019 Jan 15.

NICM Health Research Institute, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, Sydney, NSW, 2751, Australia.

Background: Endometriosis has a significant negative impact on the lives of women, and current medical treatments often do not give sufficient pain relief or have intolerable side effects for many women. The majority of women with primary dysmenorrhea use self-management strategies (including self-care techniques or lifestyle choices) to help manage period related symptoms, but little is known about self-management in women with endometriosis. The aim of this survey was to determine the prevalence of use, safety, and self-rated effectiveness of common forms of self-management. Read More

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http://dx.doi.org/10.1186/s12906-019-2431-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332532PMC
January 2019
4 Reads

Development of aqueous-based multi-herbal combination using principal component analysis and its functional significance in HepG2 cells.

BMC Complement Altern Med 2019 Jan 15;19(1):18. Epub 2019 Jan 15.

Department of Botanical & Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

Background: The present study was carried out to prepare multi-herbal combination via comparing antioxidant activity and polyphenolic composition of five medicinal plant extracts of Punica granatum L., Putranjiva roxburghii Wall., Swertia chirata Buch. Read More

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http://dx.doi.org/10.1186/s12906-019-2432-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334454PMC
January 2019
2 Reads

Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-β1/SMADS/AMPK/NF-κB pathways.

BMC Complement Altern Med 2019 Jan 10;19(1):14. Epub 2019 Jan 10.

College of Traditional Chinese Medicine, Xinjiang Medical University, No. 4 Liyushan Park, Urumuqi, 830011, China.

Background: Coreopsis tinctoria Nutt is an ethnomedicine widely used in Xinjiang, China. It is consumed as a herbal tea by local Uyghur people to treat high blood pressure and diarrhea. Our previous study confirmed that the ethyl acetate extract of Coreopsis tinctoria (AC) had a protective effect on diabetic nephropathy (DN) in an in vivo experiment. Read More

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http://dx.doi.org/10.1186/s12906-018-2410-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327481PMC
January 2019
4 Reads
2.020 Impact Factor

Suppression of lung inflammation by the ethanol extract of Chung-Sang and the possible role of Nrf2.

BMC Complement Altern Med 2019 Jan 10;19(1):15. Epub 2019 Jan 10.

Division of Applied Medicine, School of Korean Medicine, Pusan National University, PNU Rd 49, Yangsan, 50612, Republic of Korea.

Background: Asian traditional herbal remedies are typically a concoction of a major and several complementary herbs. While balancing out any adverse effect of the major herb, the complementary herbs could dilute the efficacy of the major herb, resulting in a suboptimal therapeutic effect of an herbal remedy. Here, we formulated Chung-Sang (CS) by collating five major herbs, which are used against inflammatory diseases, and tested whether an experimental formula composed of only major herbs is effective in suppressing inflammation without significant side effects. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2422-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327592PMC
January 2019
8 Reads

Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1.

BMC Complement Altern Med 2019 Jan 8;19(1):10. Epub 2019 Jan 8.

College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju, 61186, Republic of Korea.

Background: ChondroT, a new herbal medication, consists of the water extracts of Osterici Radix, Lonicerae Folium, Angelicae Gigantis Radix, Clematidis Radix, and Phellodendri Cortex (6:4:4:4:3). We previously reported that ChondroT showed significant anti-arthritis and anti-inflammatory effects.

Methods: This study was designed to evaluate the effect of ChondroT on hyperuricemia. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2415-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323677PMC
January 2019
7 Reads

Cognitive improvement effects of electro-acupuncture for the treatment of MCI compared with Western medications: a systematic review and Meta-analysis.

BMC Complement Altern Med 2019 Jan 8;19(1):13. Epub 2019 Jan 8.

Department of Oriental Neuropsychiatry, College of Korean Medicine, College of Oriental Medicine, Daejeon University, Yongun-dong, Dong-gu, Daejeon, South Korea.

Background: Almost half of mild cognitive impairment (MCI) patients progress to dementia, which is associated with decreased quality of life and obstacles to independent living. Relevant management is expected to prevent MCI patients from progressing to dementia. In recent years, electroacupuncture (EA) has been used to treat various kinds of neurological disorders including MCI. Read More

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http://dx.doi.org/10.1186/s12906-018-2407-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325879PMC
January 2019
8 Reads

Danggui Buxue Tang, an ancient Chinese herbal decoction, protects β-amyloid-induced cell death in cultured cortical neurons.

BMC Complement Altern Med 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Biology, Hanshan Normal University, Chaozhou, 521041, Guangdong, China.

Background: Danggui Buxue Tang (DBT) is a historical Chinese herbal decoction, and which has more than 800 years of applications. This herbal decoction solely contains two materials: Astragali Radix (AR) and Angelicae Sinensis Radix (ASR) at a weight ratio of 5:1. Clinically, DBT aims to improve anemia syndrome. Read More

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http://dx.doi.org/10.1186/s12906-018-2411-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323849PMC
January 2019
1 Read

The ethanolic extract of Aralia continentalis ameliorates cognitive deficits via modifications of BDNF expression and anti-inflammatory effects in a rat model of post-traumatic stress disorder.

BMC Complement Altern Med 2019 Jan 8;19(1):11. Epub 2019 Jan 8.

Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.

Background: Post-traumatic stress disorder (PTSD) is a disease associated with that the experience of traumatic stress. The traumatic experience results in the development of a prolonged stress response that causes impaired memory function and increased inflammation in the hippocampus. Currently, antidepressants are the only approved therapy for PTSD. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2417-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323859PMC
January 2019
6 Reads

The traditional Chinese formulae Ling-gui-zhu-gan decoction alleviated non-alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules.

BMC Complement Altern Med 2019 Jan 7;19(1). Epub 2019 Jan 7.

Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Background: Ling-gui-zhu-gan decoction (LGZG), a classic traditional Chinese medicine formula, has been confirmed to be effective in improving steatosis in non-alcoholic fatty liver disease (NAFLD). However, the mechanism under the efficacy remains unclear. Hence, this study was designed to investigate the mechanisms of LGZG on alleviating steatosis. Read More

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http://dx.doi.org/10.1186/s12906-018-2424-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323852PMC
January 2019
3 Reads

Antioxidants and α-glucosidase inhibitors from Neptunia oleracea fractions using H NMR-based metabolomics approach and UHPLC-MS/MS analysis.

BMC Complement Altern Med 2019 Jan 7;19(1). Epub 2019 Jan 7.

Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Background: Neptunia oleracea is a plant cultivated as vegetable in Southeast Asia. Previous works have revealed the potential of this plant as a source of natural antioxidants and α-glucosidase inhibitors. Continuing our interest on this plant, the present work is focused in identification of the bioactive compounds from different polarity fractions of N. Read More

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http://dx.doi.org/10.1186/s12906-018-2413-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322240PMC
January 2019
7 Reads

In vitro evaluation of the activity of an essential oil from Pistacia vera L. variety Bronte hull against Candida sp.

BMC Complement Altern Med 2019 Jan 7;19(1). Epub 2019 Jan 7.

Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, Via SS. Annunziata, 98168, Messina, Italy.

Background: Candida sp. represent the most common cause of fungal infections worldwide. In the present work, we have evaluated the activity of an essential oil extracted from pistachio hulls against a number of standard and clinical strains of Candida sp. Read More

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http://dx.doi.org/10.1186/s12906-018-2425-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322278PMC
January 2019
1 Read

Use of alternative medicine, ginger and licorice among Danish pregnant women - a prospective cohort study.

BMC Complement Altern Med 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of Obstetrics and Gynecology, Randers Regional Hospital, Randers, Denmark.

Background: The use of alternative medicines and dietary supplements is constantly changing, as are dietary habits. One example of this phenomenon is the current popularity of ginger products as an everyday health boost. Ginger and licorice has also been shown to ameliorate nausea a common complaint in early pregnancy. Read More

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http://dx.doi.org/10.1186/s12906-018-2419-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320632PMC
January 2019
7 Reads

Effect of Saururus chinensis leaves extract on type II collagen-induced arthritis mouse model.

BMC Complement Altern Med 2019 Jan 3;19(1). Epub 2019 Jan 3.

Tradition Korean Medicine Research Team, National Development Institute of Korean Medicine, 288, Jangheung, Seoul, 59338, South Korea.

Background: Saururus chinensis leaves have been used as traditional medicine in Korea for pain, intoxication, edema, and furuncle. According to previous reports, these leaves exert renoprotective, neuroprotective, and antioxidant effects by attenuating inflammatory responses. However, the beneficial effect of Saururus chinensis leaves on arthritis has not been elucidated. Read More

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http://dx.doi.org/10.1186/s12906-018-2418-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318964PMC
January 2019
1 Read

The anti-obesity effects of Tongbi-san in a high-fat diet-induced obese mouse model.

BMC Complement Altern Med 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Pharmacology, College of Korean Medicine, Sangji University, 83, Sangjidae-gil, Wonju-si, Gangwon-do, 26339, Republic of Korea.

Background: Recently, it has been noted that natural herbal medications may be effective in treating obesity. Tongbi-san (TBS) is a traditional medicine usually used for dysuria (i.e. Read More

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http://dx.doi.org/10.1186/s12906-018-2420-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319014PMC
January 2019
1 Read

Bio-guided profiling and HPLC-DAD finger printing of Atriplex lasiantha Boiss.

BMC Complement Altern Med 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Chemistry, University of Malakand, Khyber Pakhtunkhwa, 18000, Pakistan.

Background: Plants represent an intricate and innovative source for the discovery of novel therapeutic remedies for the management of various ailments. The current study has been aimed to validate the therapeutic potential of ethnomedicinally significant plant Atriplex lasiantha Boiss.

Methods: The polarity based extraction process was carried out using fourteen solvents to figure out best extraction solvent and bioactive fractions. Read More

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http://dx.doi.org/10.1186/s12906-018-2416-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318930PMC
January 2019
2 Reads
2.020 Impact Factor

Probiotics and yogurt modulate oxidative stress and fibrosis in livers of Schistosoma mansoni-infected mice.

BMC Complement Altern Med 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.

Background: Considerable morbidity, mortality, and economic loss result from schistosomiasis infection. Deposition of Schistosoma eggs in the hepatic portal vein is considered as the main causative agent for the development of liver fibrosis and subsequent liver cirrhosis. Probiotics are exogenous and beneficial microorganisms to living hosts against the harmful effect of many parasites. Read More

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http://dx.doi.org/10.1186/s12906-018-2406-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318950PMC
January 2019
3 Reads
2.020 Impact Factor

Gancao (Glycyrrhizae Radix) provides the main contribution to Shaoyao-Gancao decoction on enhancements of CYP3A4 and MDR1 expression via pregnane X receptor pathway in vitro.

BMC Complement Altern Med 2018 Dec 29;18(1):345. Epub 2018 Dec 29.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.

Background: Chinese herbal formula Shaoyao Gancao decoction (SGD) is often used as an adjuvant with chemotherapeutic agents to treat cancer. Due to the herb-drug interactions, the alternations of drug metabolic enzyme and drug transporters induced by SGD deserve to be explored. We aimed to investigate the effect of SGD on the pregnane X receptor (PXR)-mediated transcriptional regulation of cytochrome P450 3A4 (CYP3A4) and drug transporter multidrug resistance protein 1 (MDR1) in vitro. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2402-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311034PMC
December 2018
9 Reads

Maoberry (Antidesma bunius) ameliorates oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet.

BMC Complement Altern Med 2018 Dec 27;18(1):344. Epub 2018 Dec 27.

Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok, Thailand.

Backgound: Chronic fat-rich diets consumption is increased risk associated with cardiovascular diseases (CVD). Prevention or reduction the progression of cardiac tissue deterioration could benefit in CVD. This study aimed to examine the effects of maoberry (Antidesma bunius), a antioxidant-rich tropical fruit, supplementation on oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet (HFD). Read More

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http://dx.doi.org/10.1186/s12906-018-2400-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307262PMC
December 2018
1 Read