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    3246 results match your criteria BMC Complementary and Alternative Medicine [Journal]

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    Antioxidant capacities and total phenolic contents of 20 polyherbal remedies used as tonics by folk healers in Phatthalung and Songkhla provinces, Thailand.
    BMC Complement Altern Med 2018 Feb 21;18(1):73. Epub 2018 Feb 21.
    Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
    Background: Uses of polyherbal formulations have played a major role in traditional medicine. The present study is focused on the formulations used in traditional Thai folkloric medicine as tonics or bracers. Twenty documented polyherbal mixtures, used as nourishing tonics by the folk healers in Phatthalung and Songkhla provinces in southern Thailand, are targeted. Read More

    Correction to: Inhibition of autophagy enhances synergistic effects of Salidroside and anti-tumor agents against colorectal cancer.
    BMC Complement Altern Med 2018 Feb 21;18(1):72. Epub 2018 Feb 21.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Correction: The authors of this article [1] would like the funding and acknowledgements to be disregarded. Read More

    Repeated electroacupuncture treatment attenuated hyperalgesia through suppression of spinal glial activation in chronic neuropathic pain rats.
    BMC Complement Altern Med 2018 Feb 21;18(1):74. Epub 2018 Feb 21.
    Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing, 100700, China.
    Background: Cumulated evidence reveals that glial cells in the spinal cord play an important role in the development of chronic neuropathic pain and are also complicated in the analgesic effect of EA intervention. But the roles of microgliacytes and astrocytes of spinal cord in the process of EA analgesia remain unknown.

    Methods: A total of 120 male Wistar rats were used in the present study. Read More

    Zanthoxylum armatum DC extracts from fruit, bark and leaf induce hypolipidemic and hypoglycemic effects in mice- in vivo and in vitro study.
    BMC Complement Altern Med 2018 Feb 20;18(1):68. Epub 2018 Feb 20.
    Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, -63100, Pakistan.
    Background: Zanthoxylum armatum DC is an important medicinal plant of south East Asia, and has been used to treat various ailments in traditional medicine including diabetes. This study investigated the in vitro and in vivo antidiabetic and biochemical effects of extracts of Z. armatum in mice. Read More

    Spinacia oleracea extract attenuates disease progression and sub-chondral bone changes in monosodium iodoacetate-induced osteoarthritis in rats.
    BMC Complement Altern Med 2018 Feb 20;18(1):69. Epub 2018 Feb 20.
    Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
    Background: Spinacia oleracea is an important dietary vegetable in India and throughout the world and has many beneficial effects. It is cultivated globally. However, its effect on osteoarthritis that mainly targets the cartilage cells remains unknown. Read More

    Anti-methicillin-resistance Staphylococcus aureus (MRSA) compounds from Bauhinia kockiana Korth. And their mechanism of antibacterial activity.
    BMC Complement Altern Med 2018 Feb 20;18(1):70. Epub 2018 Feb 20.
    School of Science, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor Darul Ehsan, Malaysia.
    Background: Bauhinia kockiana originates from Peninsular Malaysia and it is grown as a garden ornamental plant. Our previous study reported that this plant exhibited fairly strong antioxidant and antimicrobial activities. This paper focused on the assessment of the antibacterial activity of B. Read More

    Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A - ATM - p53 signaling pathway.
    BMC Complement Altern Med 2018 Feb 20;18(1):71. Epub 2018 Feb 20.
    Department of Chemistry, University of Pikeville, Pikeville, KY, 41501, USA.
    Background: Pancreatic cancer is one of the leading causes of cancer related death and its incidence has risen steadily. Although anticancer drugs have been developed based on the new molecular findings, the drugs have produced unsatisfactory results due to toxicity and resistance. Thus, a complementary therapeutic intervention is urgently needed for pancreatic cancer patients. Read More

    Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting.
    BMC Complement Altern Med 2018 Feb 20;18(1):67. Epub 2018 Feb 20.
    TrueNorth Health Foundation, 1501 Pacific Avenue, Santa Rosa, CA, 95404, USA.
    Background: Evidence suggests that fasting, during which only water is consumed, results in potentially health promoting physiological effects. However, peer-reviewed research assessing the safety of water-only fasting is lacking. To address this, we conducted a chart review to describe adverse events (AEs) that occurred during medically supervised, water-only fasting. Read More

    Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials.
    BMC Complement Altern Med 2018 Feb 17;18(1):66. Epub 2018 Feb 17.
    Department of Pharmacy, Affiliated Hospital of Logistics Institute of Chinese Armed Police Force, Tianjin, 300163, China.
    Background: Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficacy and safety of Chai Hu Shu Gan San in treating depression. Read More

    Correction to: The antiangiogenic activities of ethanolic crude extracts of four Salvia species.
    BMC Complement Altern Med 2018 Feb 16;18(1):64. Epub 2018 Feb 16.
    Department of Physiology and Biochemistry, Faculty of Medicine, The University of Jordan, Amman, 11942, Jordan.
    Correction: After the publication [1] it came to the attention of the authors that one of the co-authors was incorrectly included as Hamza Somrain. The correct spelling is as follows: Hamzeh Sumrein. Read More

    Reliability of diagnosis and clinical efficacy of visceral osteopathy: a systematic review.
    BMC Complement Altern Med 2018 Feb 17;18(1):65. Epub 2018 Feb 17.
    ThEMAS team, TIMC-IMAG laboratory, UMR CNRS-UGA, 5525, Grenoble, France.
    Background: In 2010, the World Health Organization published benchmarks for training in osteopathy in which osteopathic visceral techniques are included. The purpose of this study was to identify and critically appraise the scientific literature concerning the reliability of diagnosis and the clinical efficacy of techniques used in visceral osteopathy.

    Methods: Databases MEDLINE, OSTMED. Read More

    Traditional healing practices in rural Bangladesh: a qualitative investigation.
    BMC Complement Altern Med 2018 Feb 15;18(1):62. Epub 2018 Feb 15.
    Department of Public Health, Daffodil International University, 102 & 102/1 Shukrabad, Mirpur Road, Dhanmondi, Dhaka, 1207, Bangladesh.
    Background: Traditional healing practice is an important and integral part of healthcare systems in almost all countries of the world. Very few studies have addressed the holistic scenario of traditional healing practices in Bangladesh, although these serve around 80% of the ailing people. This study explored distinctive forms of traditional healing practices in rural Bangladesh. Read More

    Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line.
    BMC Complement Altern Med 2018 Feb 15;18(1):63. Epub 2018 Feb 15.
    Department of Experimental Medicine, Section of Human Physiology, and Unit of Dietetic and Sport Medicine, University of Campania "Luigi Vanvitelli", Via Costantinopoli 16, 80138, Naples, Italy.
    Background: The thyroid gland is one of the largest endocrine glands in the body. The vast majority of TCs (> 90%) originate from follicular cells and are defined as differentiated thyroid cancers (DTC) and the two histological subtypes are the papillary TC with its variants and the follicular TC. Curcumin possesses a wide variety of biological functions, and thanks to its properties, it has gained considerable attention due to its profound medicinal values (Prasad, Gupta, Tyagi, and Aggarwal, Biotechnol Adv 32:1053-1064, 2014). Read More

    Neuroprotective effects of seaweeds against 6-hydroxidopamine-induced cell death on an in vitro human neuroblastoma model.
    BMC Complement Altern Med 2018 Feb 14;18(1):58. Epub 2018 Feb 14.
    MARE - Marine and Environmental Sciences Centre, ESTM, Instituto Politécnico de Leiria, 2520-641, Peniche, Portugal.
    Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder of the central nervous system. Although the causes of PD pathogenesis remain incomplete, some evidences has suggested that oxidative stress is an important mediator in its pathogenesis. The aim of this study was to evaluate the protective effects of seaweeds with high antioxidant activity on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in the human neuroblastoma cell line SH-SY5Y, as well as the associated intracellular signaling pathways. Read More

    Effect of tt-farnesol and myricetin on in vitro biofilm formed by Streptococcus mutans and Candida albicans.
    BMC Complement Altern Med 2018 Feb 14;18(1):61. Epub 2018 Feb 14.
    Department of Dental Materials and Prosthodontics, São Paulo State University (Unesp), School of Dentistry, Araraquara, Rua Humaitá, 1680, Araraquara, Sao Paulo, 14801-903, Brazil.
    Background: Dental caries is considered a multifactorial disease, in which microorganisms play an important role. The diet is decisive in the biofilm formation because it provides the necessary resources for cellular growth and exopolysaccharides synthesis. Exopolysaccharides are the main components of the extracellular matrix (ECM). Read More

    Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells.
    BMC Complement Altern Med 2018 Feb 14;18(1):59. Epub 2018 Feb 14.
    Guangdong Key Laboratory for Genome Stability & Disease Prevention, Cancer Research Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, China.
    Background: Gigantol is a bibenzyl compound derived from several medicinal orchids. This biologically active compound has been shown to have promising therapeutic potential against cancer cells, but its mechanism of action remains unclear.

    Methods: The inhibitory effect of gigantol on Wnt/β-catenin signaling was evaluated with the SuperTOPFlash reporter system. Read More

    In vitro antileishmanial and cytotoxicity activities of essential oils from Haplophyllum tuberculatum A. Juss leaves, stems and aerial parts.
    BMC Complement Altern Med 2018 Feb 14;18(1):60. Epub 2018 Feb 14.
    Pharmacognosy Research Group (GNOS), Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCL), B1.72.03 Av. E. Mounier 72, B-1200, Bruxelles, Belgium.
    Background: Plants used for traditional medicine produce diverse and complex secondary metabolites exhibiting various medicinal properties. The medicinal plant Haplophyllum tuberculatum is used by native people against malaria and parasitic infections.

    Methods: In this study and in order to contribute for the search of new natural drugs for leishmaniasis, the essential oils of H. Read More

    A systematic review of the effects of acupuncture on xerostomia and hyposalivation.
    BMC Complement Altern Med 2018 Feb 13;18(1):57. Epub 2018 Feb 13.
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), room 12N-37, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
    Background: Saliva is fundamental to our oral health and our well-being. Many factors can impair saliva secretion, such as adverse effects of prescribed medication, auto-immune diseases (for example Sjögren's syndrome) and radiotherapy for head and neck cancers. Several studies have suggested a positive effect of acupuncture on oral dryness. Read More

    Citral induced apoptosis in MDA-MB-231 spheroid cells.
    BMC Complement Altern Med 2018 Feb 13;18(1):56. Epub 2018 Feb 13.
    Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
    Background: Breast cancer remains a leading cause of death in women worldwide. Although breast cancer therapies have greatly advanced in recent years, many patients still develop tumour recurrence and metastasis, and eventually succumb to the disease due to chemoresistance. Citral has been reported to show cytotoxic effect on various cancer cell lines. Read More

    "Antimicrobial and antiproliferative activity of essential oil, aqueous and ethanolic extracts of Ocimum micranthum Willd leaves".
    BMC Complement Altern Med 2018 Feb 8;18(1):55. Epub 2018 Feb 8.
    Departamento de Física Aplicada, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Mérida, Km. 6 antigua carretera a Progreso, Apdo. Postal 73, Cordemex, C.P, 97310, Mérida, Yucatán, México.
    Background: Ocimum micranthum Willd is a plant used in traditional medicine practiced in the region of the Yucatan peninsula. In particular, it is used for the treatment of cutaneous infections and wound healing, however there are currently no existing scientific studies that support these applications. The aim of the present study was to evaluate the antimicrobial and the in vitro proliferative activity (on healthy mammalian cell lines) of the essential oil and extracts (aqueous and ethanolic) of this plant. Read More

    Anti-aging potential of extracts from Sclerocarya birrea (A. Rich.) Hochst and its chemical profiling by UPLC-Q-TOF-MS.
    BMC Complement Altern Med 2018 Feb 7;18(1):54. Epub 2018 Feb 7.
    Department of Biochemistry, University of Pretoria, Private Bag X20, Pretoria, 0028, South Africa.
    Background: Degradation of components of the extracellular matrix such as elastin and collagen by elastase and collagenase accelerates skin aging. Phytochemicals that inhibit the activity of these enzymes can be developed as anti-aging ingredients. In this study, an investigation of the anti-aging properties of Sclerocarya birrea (A. Read More

    Efficacy of Chinese herbal medicine Zengru Gao to promote breastfeeding: a multicenter randomized controlled trial.
    BMC Complement Altern Med 2018 Feb 6;18(1):53. Epub 2018 Feb 6.
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong.
    Background: Breastfeeding is recommended worldwide but not fully practiced. The first week after childbirth is regarded as a critical period for increasing breast milk production. The aim of the study was to investigate whether Chinese herbal medicine Zengru Gao would result in more women breastfeeding in the first week after childbirth. Read More

    Herbal compound 861 prevents hepatic fibrosis by inhibiting the TGF-β1/Smad/SnoN pathway in bile duct-ligated rats.
    BMC Complement Altern Med 2018 Feb 5;18(1):52. Epub 2018 Feb 5.
    Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China.
    Background: This study was to evaluate the effects of herbal compound 861 (Cpd861) on ski-related novel protein N (SnoN) and transforming growth factor-β1 (TGF-β1) /Smad signaling in rats with bile duct ligation (BDL)-induced hepatic fibrosis, and to explore the mechanisms of Cpd861 on hepatic fibrosis.

    Methods: Thirty Wistar male rats were randomly divided into three groups: sham operation, BDL, and Cpd861. To induce hepatic fibrosis, BDL and Cpd861 group rats underwent bile duct ligation. Read More

    Effects of Panax notoginseng saponins on severe acute pancreatitis through the regulation of mTOR/Akt and caspase-3 signaling pathway by upregulating miR-181b expression in rats.
    BMC Complement Altern Med 2018 Feb 5;18(1):51. Epub 2018 Feb 5.
    Department of Emergency, the First Hospital Affiliated To Kunming Medical University, 295 Xichang Road, Wu Hua District, Kunming, 650032, China.
    Background: In China, Panax notoginseng has been used to treat oxidative stress-related diseases for a long time. Panax notoginseng saponins is an extract from Panax notoginseng Ledeb. Its therapeutic potential is related to antioxidant activity, but related mechanisms are still unclear. Read More

    Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats.
    BMC Complement Altern Med 2018 Feb 5;18(1):50. Epub 2018 Feb 5.
    Department of Oral & Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, 50603, Malaysia.
    Background: Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon's blood, the Twobrother's Blood or Damm Alakhwain. The current study performed to evaluate the safety of the DC resin methanol extract after a single or 28 consecutive daily oral administrations. Read More

    Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue.
    BMC Complement Altern Med 2018 Feb 2;18(1):49. Epub 2018 Feb 2.
    Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    Background: Cisplatin (CP) drug is platinum compounds used for the treatment of various human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia hydaspica is a natural shrub with various pharmacological properties. Read More

    Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine.
    BMC Complement Altern Med 2018 Feb 2;18(1):47. Epub 2018 Feb 2.
    Department of Neuropsychiatry, College of Korean Medicine, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon, 34520, Republic of Korea.
    Background: So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batteries of tests as part of a safety evaluation.

    Methods: SOCG was evaluated for potential genotoxic effects using the standard three tests recommended by the Ministry of Food and Drug Safety (MFDS) of Korea. Read More

    Anti-inflammatory activities of Guang-Pheretima extract in lipopolysaccharide-stimulated RAW 264.7 murine macrophages.
    BMC Complement Altern Med 2018 Feb 1;18(1):46. Epub 2018 Feb 1.
    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou Higher Education Mega Center, 232 Wai Huan Road East, Guangzhou, 510006, China.
    Background: Guang-Pheretima, which is originated from Pheretima aspergillum, has been documented in academic Chinese herbal studies for nearly 2000 years for its prominent treating effects of various inflammatory diseases such as asthma, cough and fever. However, the anti-inflammatory activity and mechanism of Guang-Pheretima has been rarely reported. Hence, we investigated the inhibitory effect and the underlying mechanism of Guang-Pheretima aqueous extracts on inflammatory response in RAW 264. Read More

    Genotoxicity study of Ethiopian medicinal plant extracts on HepG2 cells.
    BMC Complement Altern Med 2018 Feb 1;18(1):45. Epub 2018 Feb 1.
    Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P. O. Box: 1176, Addis Ababa, Ethiopia.
    Background: Most of herbal medicines are used without any standard safety and toxicological trials although common assumption is that these products are nontoxic. However, this assumption is incorrect and dangerous, so toxicological studies should be done for herbal drugs. Although Pterolobium stellatum, Otostegia integrifolia and Vernonia amygdalina root extracts are frequently used in Ethiopian traditional medicine, there are no evidences of their active toxic compounds. Read More

    Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb.) with Phospholipase A2 (PLA2).
    BMC Complement Altern Med 2018 Feb 2;18(1):48. Epub 2018 Feb 2.
    Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, 1000, Bangladesh.
    Background: Betulinic acid (BA) is a natural triterpenoid compound and exhibits a wide range of biological and medicinal properties including anti-inflammatory activity. Therefore, this theoretical investigation is performed to evaluate (a) physicochemical properties such as acid dissociation constant (pKa), distribution coefficient (logD), partition coefficient (logP), aqueous solubility (logS), solvation free energy, dipole moment, polarizability, hyperpolarizability and different reactivity descriptors, (b) pharmacokinetic properties like human intestinal absorption (HIA), cellular permeability, skin permeability (P), plasma protein binding (PPB), penetration of the blood brain barrier (BBB), (c) toxicological properties including mutagenicity, carcinogenicity, risk of inhibition of hERG gene and (d) molecular mechanism of anti-inflammatory action which will aid the development of analytical method and the synthesis of BA derivatives.

    Methods: The physicochemical properties were calculated using MarvinSketch 15. Read More

    Phytochemical investigation and antimicrobial appraisal of Parrotiopsis jacquemontiana (Decne) Rehder.
    BMC Complement Altern Med 2018 Jan 31;18(1):43. Epub 2018 Jan 31.
    Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
    Background: Parrotiopsis jacquemontiana (Decne) Rehder. is locally used for skin infections and in wound healing. In this study we have evaluated methanol extract of its leaves and derived fractions against the clinical multi-drug resistant bacterial strains. Read More

    Attitudes and knowledge about direct and indirect risks among conventional and complementary health care providers in cancer care.
    BMC Complement Altern Med 2018 Jan 31;18(1):44. Epub 2018 Jan 31.
    The National Research Center in Complementary and Alternative Medicine (NAFKAM), Department of Community Medicine, UiT The Arctic University of Norway, Sykehusveien 21, 9037, Tromsø, Norway.
    Background: Many complementary therapies offer benefits for patients with cancer. Others may be risky for patients due to negative interactions with conventional treatment and adverse effects. Therefore, cancer patients need guidance from health care providers to assess complementary modalities appropriately to receive benefits and avoid harm. Read More

    Comparative efficacy of Chinese herbal injections for treating chronic heart failure: a network meta-analysis.
    BMC Complement Altern Med 2018 Jan 31;18(1):41. Epub 2018 Jan 31.
    Department of Clinical Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China.
    Background: On account of deterioration of chronic heart failure (CHF) and extensive exploration of Chinese herbal injections (CHIs), we performed a network meta-analysis to investigate the efficacy of CHIs (Huangqi injection, Shenfu injection, Shengmai injection, Shenmai injection, Shenqi Fuzheng injection, Yiqifumai injection) on the basis of western medicine (WM) treatment in CHF.

    Methods: Literature search was conducted in Embase, the Cochrane Library, Pubmed, Chinese Biological Medicine Database, China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database from inception to June 12nd 2017, and study selection was abided by a prior eligible criteria.

    Results: Ultimately, a total of 113 randomized controlled trials (RCTs) were enrolled. Read More

    The association between cold hypersensitivity in the hands and feet and chronic disease: results of a multicentre study.
    BMC Complement Altern Med 2018 Jan 31;18(1):40. Epub 2018 Jan 31.
    Mibyeong Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.
    Background: Cold hypersensitivity in the hands and feet (CHHF) is a common symptom in Korea and patients with CHHF complain of coldness in the hands and feet in an environment that is not considered cold by unaffected people. In traditional East Asian medicine, CHHF is believed to be accompanied by various diseases and symptoms, and is considered a symptom that needs active treatment. CHHF is used for pattern identification in the cold pattern, yang deficiency, and constitution. Read More

    Urox containing concentrated extracts of Crataeva nurvala stem bark, Equisetum arvense stem and Lindera aggregata root, in the treatment of symptoms of overactive bladder and urinary incontinence: a phase 2, randomised, double-blind placebo controlled trial.
    BMC Complement Altern Med 2018 Jan 31;18(1):42. Epub 2018 Jan 31.
    School of Health Sciences, University of Tasmania, Locked Bag 1322, Launceston, Tasmania, 7250, Australia.
    Background: Storage lower urinary tract symptoms (LUTS) including overactive bladder (OAB) and urinary incontinence (UI) affect millions of people worldwide, significantly impacting quality of life. Plant based medicines have been documented both empirically and in emerging scientific research to have varying benefits in reducing bladder symptoms. We assessed the efficacy of Urox®, a proprietary combination of phytomedicine extracts including, Cratevox™ (Crataeva nurvala) stem bark, Equisetem arvense stem and Lindera aggregata root, in reducing symptoms of OAB and UI. Read More

    The flavonoid hesperidin exerts anti-photoaging effect by downregulating matrix metalloproteinase (MMP)-9 expression via mitogen activated protein kinase (MAPK)-dependent signaling pathways.
    BMC Complement Altern Med 2018 Jan 30;18(1):39. Epub 2018 Jan 30.
    KM Convergence Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 34054, South Korea.
    Background: Hesperidin is a flavonoid with antioxidant, anti-inflammatory, and immune modulatory activities. Photoaging is a consequence of chronic exposure to the sun and ultraviolet (UV) radiation. This study was designed to evaluate the efficacy of hesperidin against photoaging of dorsal skin in hairless mice. Read More

    Study on the inhibition of Mfn1 by plant-derived miR5338 mediating the treatment of BPH with rape bee pollen.
    BMC Complement Altern Med 2018 Jan 30;18(1):38. Epub 2018 Jan 30.
    Institute of Basic Medicine, Zhejiang Academy of Traditional Chinese Medicine, No. 132, Tianmushan Road, Xihu District, Hangzhou, Zhejiang, China.
    Background: Recent studies have found that plant derived microRNA can cross-kingdom regulate the expression of genes in humans and other mammals, thereby resisting diseases. Can exogenous miRNAs cross the blood-prostate barrier and entry prostate then participate in prostate disease treatment?

    Methods: Using HiSeq sequencing and RT-qPCR technology, we detected plant miRNAs that enriched in the prostates of rats among the normal group, BPH model group and rape bee pollen group. To forecast the functions of these miRNAs, the psRobot software and TargetFinder software were used to predict their candidate target genes in rat genome. Read More

    Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging.
    BMC Complement Altern Med 2018 Jan 29;18(1):33. Epub 2018 Jan 29.
    Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
    Background: Skin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages. Reactive oxygen species induced oxidative stress plays a major role in skin aging by modulating the elastase enzyme level in the skin. Read More

    Sheng-ji Hua-yu formula promotes diabetic wound healing of re-epithelization via Activin/Follistatin regulation.
    BMC Complement Altern Med 2018 Jan 29;18(1):32. Epub 2018 Jan 29.
    Department of Dermatology of Yueyang Hospital, Shanghai University of TCM, Shanghai, 200437, China.
    Background: Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in the treatment of the delayed diabetic wound. However, elucidating the related molecular biological mechanism of how the SJHY Formula affects excessive inflammation in the process of re-epithelialization of diabetic wound healing is a task urgently needed to be fulfilled. The objectives of this study is to evaluate the effect of antagonisic expression of pro-/anti-inflammatory factors on transforming growth factor-β(TGF-β) superfamily (activin and follistatin) in the process of re-epithelialization of diabetic wound healing in vivo, and to characterize the involvement of the activin/follistatin protein expression regulation, phospho-Smad (pSmad2), and Nuclear factor kappa B p50 (NF-kB) p50 in the diabetic wound healing effects of SJHY formula. Read More

    Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells.
    BMC Complement Altern Med 2018 Jan 30;18(1):36. Epub 2018 Jan 30.
    Department of Biology, Science Faculty, Anadolu University, Eskişehir, Turkey.
    Background: Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ways to fight malignancies. The cytotoxicity of 14 compounds from African medicinal plants was evaluated in four human carcinoma cell lines and normal fibroblasts. Read More

    Screening of Baccaurea ramiflora (Lour.) extracts for cytotoxic, analgesic, anti-inflammatory, neuropharmacological and antidiarrheal activities.
    BMC Complement Altern Med 2018 Jan 30;18(1):35. Epub 2018 Jan 30.
    Beximco Pharmaceutical Ltd, Dhaka, Bangladesh.
    Background: It has been observed that the various part of Baccaurea ramiflora plant is used in rheumatoid arthritis, cellulitis, abscesses, constipation and injuries. This plant also has anticholinergic, hypolipidemic, hypoglycemic, antiviral, antioxidant, diuretic and cytotoxic activities. The present studyaimed to assess the cytotoxic, analgesic, anti-inflammatory, CNS depressant and antidiarrheal activities of methanol extract of Baccaurea ramiflora pulp and seeds in mice model. Read More

    Stimulatory effect of icariin on the proliferation of neural stem cells from rat hippocampus.
    BMC Complement Altern Med 2018 Jan 29;18(1):34. Epub 2018 Jan 29.
    Joint International Research Laboratory of Ethnomedicine, Zunyi Medical College, Zunyi, Guizhou, China.
    Background: Icariin (ICA), a major ingredient of Epimediumbrevicornum, has various pharmacological activities including central nervous system protective functions such as the improvement of learning and memory function in mice models of Alzheimer's disease. It has been reported that ICA can promote regeneration of peripheral nerve and functional recovery. The purpose of this study was to investigate the potentiating effect of ICA on the proliferation of rat hippocampal neural stem cells, and explore the possible mechanism involved. Read More

    Anti-apoptotic potential of several antidiabetic medicinal plants of the eastern James Bay Cree pharmacopeia in cultured kidney cells.
    BMC Complement Altern Med 2018 Jan 30;18(1):37. Epub 2018 Jan 30.
    Department of Pharmacology and Physiology, Université de Montréal, P.O. Box 6128, Downtown Postal Station, Montreal, (Quebec), H3C 3J7, Canada.
    Background: Our team has identified 17 Boreal forest species from the traditional pharmacopeia of the Eastern James Bay Cree that presented promising in vitro and in vivo biological activities in the context of type 2 diabetes (T2D). We now screened the 17 plants extracts for potential anti-apoptotic activity in cultured kidney cells and investigated the underlying mechanisms.

    Methods: MDCK (Madin-Darnby Canine Kidney) cell damage was induced by hypertonic medium (700 mOsm/L) in the presence or absence of maximal nontoxic concentrations of each of the 17 plant extracts. Read More

    Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L.
    BMC Complement Altern Med 2018 Jan 27;18(1):31. Epub 2018 Jan 27.
    Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400, Serdang, Malaysia.
    Background: Morinda citrifolia L. that was reported with immunomodulating and cytotoxic effects has been traditionally used to treat multiple illnesses including cancer. An anthraquinone derived from fruits of Morinda citrifolia L. Read More

    Dual function of active constituents from bark of Ficus racemosa L in wound healing.
    BMC Complement Altern Med 2018 Jan 25;18(1):29. Epub 2018 Jan 25.
    Department of Botany, The Open University of Sri Lanka, Nawala, Nugegoda, Sri Lanka.
    Background: Different parts including the latex of Ficus racemosa L. has been used as a medicine for wound healing in the Ayurveda and in the indigenous system of medicine in Sri Lanka. This plant has been evaluated for its wound healing potential using animal models. Read More

    Anti-proliferative and cytotoxic activities of Allium autumnale P. H. Davis (Amaryllidaceae) on human breast cancer cell lines MCF-7 and MDA-MB-231.
    BMC Complement Altern Med 2018 Jan 25;18(1):30. Epub 2018 Jan 25.
    Biotechnology Research Center, Cyprus International University, Nicosia, 99258, Northern Cyprus via Mersin 10, Turkey.
    Background: Natural products obtained from plants can be potent sources for developing a variety of pharmaceutical products. Allium species have been widely studied for their anti-cancer effects and presented promising results as potential anti-cancer agents. Breast cancer (BCa) is one of the most commonly diagnosed types of cancer in women. Read More

    Evaluation of biological potential of selected species of family Poaceae from Bahawalpur, Pakistan.
    BMC Complement Altern Med 2018 Jan 24;18(1):27. Epub 2018 Jan 24.
    Department of Plant Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
    Background: Oxidative stress as well as bacterial and fungal infections are common source of diseases while plants are source of medication for curative or protective purposes. Hence, aim of study was to compare the pharmacological potential of seven grass species in two different solvents i.e. Read More

    Long-term effects of Garcinia cambogia/Glucomannan on weight loss in people with obesity, PLIN4, FTO and Trp64Arg polymorphisms.
    BMC Complement Altern Med 2018 Jan 24;18(1):26. Epub 2018 Jan 24.
    Department of Morphological Sciences, School of Medicine, University of Córdoba, Avenida de Menéndez Pidal s/n, 14071, Córdoba, Spain.
    Background: Overweight and obesity are considered major health problems that contribute to increase mortality and quality of life. Both conditions have a high prevalence across the world reaching epidemic numbers. Our aim was to evaluate the effects of the administration of Garcinia cambogia (GC) and Glucomannan (GNN) on long-term weight loss in people with overweight or obesity. Read More

    Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/Ginkgoselect®Plus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx].
    BMC Complement Altern Med 2018 Jan 22;18(1):22. Epub 2018 Jan 22.
    Laboratory of Biosafety and Risk Assessment, ENEA CR Casaccia, Via Anguillarese, 301, 00123, Rome, Italy.
    Background: Numerous health benefits have been attributed to the Ginkgo biloba leaf extract (GBLE), one of the most extensively used phytopharmaceutical drugs worldwide. Recently, concerns of the safety of the extract have been raised after a report from US National Toxicology Program (NTP) claimed high doses of GBLE increased liver and thyroid cancer incidence in mice and rats. A safety study has been designed to assess, in a population of elderly residents in nursing homes, clinical and genomic risks associated to GBLE treatment. Read More

    The genotoxicity of an aqueous extract of Gyejibokryeong-hwan.
    BMC Complement Altern Med 2018 Jan 22;18(1):21. Epub 2018 Jan 22.
    K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 305-811, Republic of Korea.
    Background: Gyejibokryeong-hwan (Guizhi Fuling Wan in China), a mixture of five herbal plants, is a well-known treatment for renal diseases including those associated with climacteric syndrome. However, the genotoxicity of Gyejibokryeong-hwan has not yet been well established.

    Methods: The present study investigated that the genotoxicity of an aqueous extract of Gyejibokryeong-hwan (GJBRHE): an in vitro chromosomal aberration test using Chinese hamster lung cells, an in vitro bacterial reverse mutation assay (Ames test) with Salmonella typhimurium and Escherichia coli strains, and an in vivo micronucleus test using ICR mouse bone marrow. Read More

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