3,892 results match your criteria BMC Complementary and Alternative Medicine [Journal]


Complementary medicine use among Australian patients in an acute hospital setting: an exploratory, cross sectional study.

BMC Complement Altern Med 2019 Dec 21;19(1):374. Epub 2019 Dec 21.

Room12C21, University of Canberra, ACT, Bruce, 2615, Australia.

Background: The use of Complementary Medicines (CMs) has significantly increased in Australia over the last decade. This study attempts to determine the extent to which complementary and alternative medicines are recorded, ceased or initiated in the acute hospital setting and investigate which health professionals have a role in this process.

Methods: A cross-sectional study of inpatients was conducted at a major tertiary teaching hospital. Read More

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http://dx.doi.org/10.1186/s12906-019-2788-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925895PMC
December 2019

Anti-inflammatory, analgesic and acute toxicity effects of fermented soybean.

BMC Complement Altern Med 2019 Dec 19;19(1):373. Epub 2019 Dec 19.

Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Background: Tempeh is a widely known fermented soybean that contains elevated level of bioactive contents. Our previous study has shown that anaerobic fermented Nutrient Enriched Soybean Tempeh (NESTE) with increase amino acid and antioxidant levels possessed better hepatoprotective effect than raw soybean.

Methods: In this study, the anti-inflammatory effect of the NESTE aqueous extract and raw soybean aqueous extract (SBE) were evaluated by quantifying the inhibition of IL-1β, TNF-α and nitric oxide (NO) secretion in LPS treated RAW 264. Read More

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http://dx.doi.org/10.1186/s12906-019-2791-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923968PMC
December 2019

Alcohol extract from Vernonia anthelmintica willd (L.) seed counteracts stress-induced murine hair follicle growth inhibition.

BMC Complement Altern Med 2019 Dec 17;19(1):372. Epub 2019 Dec 17.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, JiangSu Province, People's Republic of China.

Background: Vernonia anthelmintica (L.) willd is a traditional urgur herb in China for a long history. Its alcohol extract (AVE) has been proved to promote hair follicle growth in C57BL/6 mice. Read More

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http://dx.doi.org/10.1186/s12906-019-2744-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918677PMC
December 2019
2.020 Impact Factor

Treatment of migraines with Tianshu capsule: a multi-center, double-blind, randomized, placebo-controlled clinical trial.

BMC Complement Altern Med 2019 Dec 16;19(1):370. Epub 2019 Dec 16.

The 260th Hospital of PLA, Shijiazhuang, Hebei, China.

Background: Tianshu capsule (TSC), a formula of traditional Chinese medicine, has been widely used in clinical practice for prophylactic treatment of headaches in China. However, former clinical trials of TSC were small, and lack of a standard set of diagnostic criteria to enroll patients. The study was conducted to re-evaluate the efficacy and safety of TSC post-marketing in an extending number of migraineurs who have diagnosed migraine with the International Classification of Headache Disorders, 3rd edition (beta version, ICHD-3β). Read More

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http://dx.doi.org/10.1186/s12906-019-2775-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915862PMC
December 2019

Canscora lucidissima, a Chinese folk medicine, exerts anti-inflammatory activities by inhibiting the phosphorylation of ERK1/2 in LPS-activated macrophages.

BMC Complement Altern Med 2019 Dec 16;19(1):371. Epub 2019 Dec 16.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, 151 North Ma Lian Wa Road, Haidian District, Beijing, 100193, China.

Background: Canscora lucidissima (Levl. & Vaniot) Hand.-Mazz. Read More

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http://dx.doi.org/10.1186/s12906-019-2783-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916437PMC
December 2019

Effective fraction of Bletilla striata reduces the inflammatory cytokine production induced by water and organic extracts of airborne fine particulate matter (PM) in vitro.

BMC Complement Altern Med 2019 Dec 16;19(1):369. Epub 2019 Dec 16.

College of Medical Technology, Zhejiang Chinese Medical University, Zhejiang, 310053, Hangzhou, China.

Background: Bletilla striata is a traditional Chinese medicine used to treat hemorrhage, scald, gastric ulcer, pulmonary diseases and inflammations. In this study, we investigated bioactivity of the effective fraction of B. striata (EFB) in reducing the inflammatory cytokine production induced by water or organic extracts of PM. Read More

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http://dx.doi.org/10.1186/s12906-019-2790-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916096PMC
December 2019

Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice.

BMC Complement Altern Med 2019 Dec 13;19(1):368. Epub 2019 Dec 13.

Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, 11001, Taiwan.

Background: Obesity and its associated health conditions, type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), are worldwide health problems. It has been shown that insulin resistance is associated with increased hepatic lipid and causes hepatic steatosis through a myriad of mechanisms, including inflammatory signaling.

Methods: Helminthostachys zeylanica (HZ) is used widely as a common herbal medicine to relieve fever symptoms and inflammatory diseases in Asia. Read More

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http://dx.doi.org/10.1186/s12906-019-2782-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911300PMC
December 2019

Oral and injectable Marsdenia tenacissima extract (MTE) as adjuvant therapy to chemotherapy for gastric cancer: a systematic review.

BMC Complement Altern Med 2019 Dec 12;19(1):366. Epub 2019 Dec 12.

Evidence-based Medicine Research Center, Jiangxi University of Traditional Chinese Medicine, Jiangxi, China.

Background: Marsdenia tenacissima extract (MTE) is a phytochemical widely used as complementary therapy in cancer care. This systematic review was conducted to investigate the anticancer and detoxification effects of MTE, as an adjuvant therapy to chemotherapy, for treating gastric cancer.

Methods: Ten databases were searched to identify randomized controlled trials (RCTs) comparing oral or injectable MTE plus chemotherapy versus chemotherapy alone for treating gastric cancer up to May 1, 2019. Read More

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http://dx.doi.org/10.1186/s12906-019-2779-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909592PMC
December 2019

The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines.

BMC Complement Altern Med 2019 Dec 12;19(1):365. Epub 2019 Dec 12.

Department of Natural Sciences, Lebanese American University, Byblos, Lebanon.

Background: The edible fruit Annona cherimola has previously shown many nutritional and medicinal properties. The current study evaluates the anti-cancer and anti-proliferative properties of Annona cherimola ethanolic leaf extract (AELE) on Acute Myeloid Leukemia (AML) cell lines cultured in vitro (Monomac-1 and KG-1).

Methods: The anti-proliferative effect of A. Read More

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http://dx.doi.org/10.1186/s12906-019-2768-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909458PMC
December 2019
2.020 Impact Factor

A 13-Week Repeated Oral Dose Toxicity Study of ChondroT in Sprague-Dawley Rats.

BMC Complement Altern Med 2019 Dec 12;19(1):367. Epub 2019 Dec 12.

College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju, 58245, Jeollanam-do, Republic of Korea.

Background: ChondroT, a new herbal medication, consists of Angelica grosseserrata Maxim., Lonicera japonica Thunb., Angelica gigas Nakai, Clematis terniflora var. Read More

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http://dx.doi.org/10.1186/s12906-019-2773-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909520PMC
December 2019

The effectiveness of traditional Japanese medicine Goshajinkigan in irradiation-induced aspermatogenesis in mice.

BMC Complement Altern Med 2019 Dec 11;19(1):362. Epub 2019 Dec 11.

Department of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.

Background: Infertility and gonadal dysfunction are well known side-effects by cancer treatment in males. In particularly, chemotherapy and radiotherapy induced testicular damage, resulting in prolonged azoospermia. However, information regarding therapeutics to treat spermatogenesis disturbance after cancer treatment is scarce. Read More

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http://dx.doi.org/10.1186/s12906-019-2786-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907346PMC
December 2019

In vitro anti-allergic activity of Moringa oleifera Lam. extracts and their isolated compounds.

BMC Complement Altern Med 2019 Dec 11;19(1):361. Epub 2019 Dec 11.

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

Background: Moringa oleifera Lam. is a commonly used plant in herbal medicine and has various reported bioactivities such as antioxidant, antimicrobial, anticancer and antidiabetes. It is rich in nutrients and polyphenols. Read More

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http://dx.doi.org/10.1186/s12906-019-2776-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907282PMC
December 2019

Anti-adipogenic and anti-obesity activities of purpurin in 3T3-L1 preadipocyte cells and in mice fed a high-fat diet.

BMC Complement Altern Med 2019 Dec 11;19(1):364. Epub 2019 Dec 11.

Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, California, 94710, USA.

Background: The body responds to overnutrition by converting stem cells to adipocytes. In vitro and in vivo studies have shown polyphenols and other natural compounds to be anti-adipogenic, presumably due in part to their antioxidant properties. Purpurin is a highly antioxidative anthraquinone and previous studies on anthraquinones have reported numerous biological activities in cells and animals. Read More

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http://dx.doi.org/10.1186/s12906-019-2756-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907186PMC
December 2019

Efficacy and safety of oral Guanxinshutong capsules in patients with stable angina pectoris in China: a prospective, multicenter, double-blind, placebo-controlled, randomized clinical trial.

BMC Complement Altern Med 2019 Dec 11;19(1):363. Epub 2019 Dec 11.

Department of Cardiology, General Hospital of Northern Theater Command, 83 Wenhua Rd, Shenyang, 110016, Liaoning Province, China.

Background: To assess the efficacy and safety of oral Guanxinshutong (GXST) capsules in Chinese patients with stable angina pectoris (SAP) in a prospective, multicenter, double-Blind, placebo-controlled, randomized clinical trial (clinicaltrials.gov Identifier: NCT02280850).

Methods: Eligible patients were randomized 1:1 to the GXST or placebo group. Read More

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http://dx.doi.org/10.1186/s12906-019-2778-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907120PMC
December 2019
2.020 Impact Factor

Lingguizhugan decoction attenuates doxorubicin-induced heart failure in rats by improving TT-SR microstructural remodeling.

BMC Complement Altern Med 2019 Dec 11;19(1):360. Epub 2019 Dec 11.

College of International Education, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.

Background: Lingguizhugan decoction (LGZG), an ancient Chinese herbal formula, has been used to treat cardiovascular diseases in eastern Asia. We investigated whether LGZG has protective activity and the mechanism underlying its effect in an animal model of heart failure (HF).

Methods: A rat model of HF was established by administering eight intraperitoneal injections of doxorubicin (DOX) (cumulative dose of 16 mg/kg) over a 4-week period. Read More

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http://dx.doi.org/10.1186/s12906-019-2771-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907350PMC
December 2019

Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling.

BMC Complement Altern Med 2019 Dec 10;19(1):359. Epub 2019 Dec 10.

Comprehensive Cancer Center, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, China.

Background: Corydalis yanhusuo W.T. Wang (YHS) is a well-known Chinese flowering herbal plant commonly used for centuries in functional food and traditional Chinese medicine. Read More

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http://dx.doi.org/10.1186/s12906-019-2739-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905101PMC
December 2019
2.020 Impact Factor

Oolong tea consumption and its interactions with a novel composite index on esophageal squamous cell carcinoma.

BMC Complement Altern Med 2019 Dec 10;19(1):358. Epub 2019 Dec 10.

Department of Epidemiology and Health Statistics, Fujian Medical University Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of public Health, Fujian Medical University, Fuzhou, 350108, China.

Background: No previous study has investigated the association between oolong tea consumption and esophageal squamous cell carcinoma (ESCC), we aim to elucidate the association between oolong tea consumption and ESCC and its joint effects with a novel composite index.

Methods: In a hospital-based case-control study, 646 cases of ESCC patients and 646 sex and age matched controls were recruited. A composite index was calculated to evaluate the role of demographic characteristics and life exposure factors in ESCC. Read More

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http://dx.doi.org/10.1186/s12906-019-2770-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902529PMC
December 2019

Clinical evidence-guided network pharmacology analysis reveals a critical contribution of β1-adrenoreceptor upregulation to bradycardia alleviation by Shenxian-Shengmai.

BMC Complement Altern Med 2019 Dec 10;19(1):357. Epub 2019 Dec 10.

State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.

Background: Shenxian-Shengmai (SXSM) Oral Liquid is a CFDA-approved patent Chinese Herbal medicine, which has been clinically used for the treatment of bradycardia. However, its active components and action mechanism remain to be established. The present study aimed to evaluate the efficacy of SXSM on bradycardia and to identify the possible active components and their pharmacological targets for this action. Read More

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http://dx.doi.org/10.1186/s12906-019-2769-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902583PMC
December 2019

The combination of Radix Astragali and Radix Angelicae Sinensis attenuates the IFN-γ-induced immune destruction of hematopoiesis in bone marrow cells.

BMC Complement Altern Med 2019 Dec 9;19(1):356. Epub 2019 Dec 9.

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Haiyuncang Hutong No.5, Dongcheng District, Beijing, China.

Background: Radix Astragali and Radix Angelicae Sinensis are two herbs that compose Danggui Buxue Tang (an herbal formula for treatment of anemia diseases). In this study, we explored the molecular mechanism and effective targets to immune destruction of bone marrow (BM) cells treated with Radix Astragali, Radix Angelicae Sinensis or a combination of two agents. The potential synergic advantages of two herbs should also be explored. Read More

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http://dx.doi.org/10.1186/s12906-019-2781-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902408PMC
December 2019

Ethno-pharmacological survey of herbal remedies used in the treatment of paediatric diseases in Buhunga parish, Rukungiri District, Uganda.

BMC Complement Altern Med 2019 Dec 5;19(1):353. Epub 2019 Dec 5.

Department of Plant Sciences, Microbiology & Biotechnology, Makerere University, P.O Box 7062, Kampala, Uganda.

Background: Plants have been used as a primary source of medicine since ancient times and about 80% of the world's population use herbal medicine to treat different ailments. Plant use knowledge differs in space and time and thus requires documentation to avoid its loss from one generation to another.

Methods: In order to accomplish the survey, semi-structured questionnaires were used. Read More

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http://dx.doi.org/10.1186/s12906-019-2763-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896270PMC
December 2019

ACE inhibitory peptides in standard and fermented deer velvet: an in silico and in vitro investigation.

BMC Complement Altern Med 2019 Dec 5;19(1):350. Epub 2019 Dec 5.

AgResearch Limited, Lincoln Research Centre, Private Bag 4749, Christchurch, 8140, New Zealand.

Background: The use of deer velvet antler (DVA) as a potent traditional medicine ingredient goes back for over 2000 years in Asia. Increasingly, though, DVA is being included as a high protein functional food ingredient in convenient, ready to consume products in Korea and China. As such, it is a potential source of endogenous bioactive peptides and of 'cryptides', i. Read More

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http://dx.doi.org/10.1186/s12906-019-2758-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896680PMC
December 2019

Systems pharmacology based approach to investigate the in-vivo therapeutic efficacy of Albizia lebbeck (L.) in experimental model of Parkinson's disease.

BMC Complement Altern Med 2019 Dec 5;19(1):352. Epub 2019 Dec 5.

Riphah Institute of Pharmaceutical sciences, Riphah International University, Lahore, Pakistan.

Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopaminergic neurons in substantia nigra pars compacta and clinically manifested mainly with motor dysfunctions. Plants are rich source of medicinally important bioactive compounds and inhabitants of underdeveloped countries used plants for treatment of various ailments. Albizia lebbeck has been reported to possess antioxidant and neuroprotective properties that suggest the evaluation of its traditional therapeutic potential in neurodegenerative diseases. Read More

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http://dx.doi.org/10.1186/s12906-019-2772-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896792PMC
December 2019
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Effects of fish oil supplement on psoriasis: a meta-analysis of randomized controlled trials.

BMC Complement Altern Med 2019 Dec 5;19(1):354. Epub 2019 Dec 5.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, 5, Fuxing St, Guishan Dist, Taoyuan, 33305, Taiwan.

Background: Fish oils, which contain omega-3 polyunsaturated fatty acids as the active ingredients, possess anti-inflammatory activities and may have therapeutic potential in diseases with an inflammatory etiology. Fish oil supplement has been advocated for treating psoriasis which is a chronic inflammatory dermatosis.

Objective: We aimed to investigate the effects of fish oil supplement on psoriasis. Read More

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http://dx.doi.org/10.1186/s12906-019-2777-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896351PMC
December 2019

Astragaloside IV protects against diabetic nephropathy via activating eNOS in streptozotocin diabetes-induced rats.

BMC Complement Altern Med 2019 Dec 5;19(1):355. Epub 2019 Dec 5.

Department of Pharmacy and Pharmacology, Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, 100029, People's Republic of China.

Background: Astragaloside IV (AS-IV) was reported to play a role in improving diabetic nephropathy (DN), however, the underlying mechanisms still remain unclear. The aim of the present study is to investigate whether AS-IV ameliorates DN via the regulation of endothelial nitric oxide synthase (eNOS).

Methods: DN model was induced in Sprague-Dawley (SD) male rats by intraperitoneal injection of 65 mg/kg streptozotocin (STZ). Read More

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http://dx.doi.org/10.1186/s12906-019-2728-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896771PMC
December 2019

Anti-HIV-1 protease activity of the crude extracts and isolated compounds from Auricularia polytricha.

BMC Complement Altern Med 2019 Dec 5;19(1):351. Epub 2019 Dec 5.

Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: Acquired immunodeficiency syndrome (AIDS) is caused by the Human immunodeficiency virus type-1 (HIV-1). HIV-1 protease (HIV-1 PR) is an essential enzyme for the HIV replication, and therefore, it is an important target for antiretroviral drugs development, particularly from natural products. Auricularia polytricha (AP) is an edible mushroom with several important therapeutic properties. Read More

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http://dx.doi.org/10.1186/s12906-019-2766-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896332PMC
December 2019

Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum leaves and its effect on lung pathological changes in an ovalbumin-induced rat model of asthma.

BMC Complement Altern Med 2019 Dec 4;19(1):349. Epub 2019 Dec 4.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Ocimum species (Lamiaceae) has been traditionally used for treatment of upper respiratory tract infections, bronchitis, coughs, sore throat, and wound healing. The Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum (O. basilicum) leaves was examined in ovalbumin sensitized animals. Read More

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http://dx.doi.org/10.1186/s12906-019-2765-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894265PMC
December 2019

Pharmacological and computational evaluation of fig for therapeutic potential in hyperactive gastrointestinal disorders.

BMC Complement Altern Med 2019 Dec 3;19(1):348. Epub 2019 Dec 3.

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.

Background: Ficus palmata (Fig), are distributed in different parts of the world, and are used in traditional medicine to treat various ailments including inflammation, tumor, epilepsy, jaundice, influenza and bacillary dysentery. The present study aimed to evaluate the antidiarrheal, antisecretary, antispasmodic, antiulcer and anti motility properties of Ficus palmata.

Methods: In-vivo, in-vitro and in-silico techniques were used to investigate various gastrointestinal effects of Ficus palmata. Read More

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http://dx.doi.org/10.1186/s12906-019-2759-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889615PMC
December 2019

Water-separated part of Chloranthus serratus alleviates lipopolysaccharide- induced RAW264.7 cell injury mainly by regulating the MAPK and Nrf2/HO-1 inflammatory pathways.

BMC Complement Altern Med 2019 Dec 2;19(1):343. Epub 2019 Dec 2.

College of Life Science, Anhui Normal University, Wuhu, 241000, Anhui, China.

Background: Chloranthus serratus (Chloranthaceae) has been used to treat bruises, rheumatoid and bone pain. However, the anti-inflammatory mechanisms of C. serratus in vitro have not been fully elucidated. Read More

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http://dx.doi.org/10.1186/s12906-019-2755-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888926PMC
December 2019

The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro.

BMC Complement Altern Med 2019 Dec 2;19(1):342. Epub 2019 Dec 2.

NIS Labs, 1437 Esplanade, Klamath Falls, Oregon, 97601, USA.

Background: The medicinal mushroom Trametes versicolor (Tv, Turkey Tail) is often prepared for consumption as a powder from the fungal mycelium and the fermented substrate on which it grew. The goal for this study was to evaluate the immune-modulating properties of the mycelium versus the fermented substrate, to document whether an important part of the immune-activating effects resides in the metabolically fermented substrate.

Methods: Tv mycelium was cultured on rice flour. Read More

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http://dx.doi.org/10.1186/s12906-019-2681-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889544PMC
December 2019

Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats.

BMC Complement Altern Med 2019 Dec 2;19(1):344. Epub 2019 Dec 2.

Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 UPM, Serdang, Malaysia.

Background: Mangosteen is a native fruit from Southeast Asia. It is rich in phenolic compounds such as xanthones, anthocyanins and phenolic acids. Mangosteen pericarp extract showed inhibitory activity towards pancreatic lipase and may have potential use for obesity treatment. Read More

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http://dx.doi.org/10.1186/s12906-019-2764-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889675PMC
December 2019

Anti-inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz. root bark on imiquimod-induced psoriasis.

BMC Complement Altern Med 2019 Dec 2;19(1):347. Epub 2019 Dec 2.

School of Life Science, BK21 Plus KNU Creative Bioresearch Group, Kyungpook National University, 80 Daehakro, Bukgu, Daegu, 41566, South Korea.

Background: The root bark of Dictamnus dasycarpus Turcz. has been successfully used for the treatment of inflammatory skin conditions such as eczema and pruritus. However, the anti-psoriatic effect of this plant has not until now been investigated. Read More

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http://dx.doi.org/10.1186/s12906-019-2767-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889627PMC
December 2019

Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats.

BMC Complement Altern Med 2019 Dec 2;19(1):345. Epub 2019 Dec 2.

Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Background: Cuphea ignea is one of the herbal resources belonging to Lythraceae family. Some species of this family have been used traditionally in South and Central America's folk medicine for treating stomach disorders. Therefore, the present study was performed to evaluate the gastropreventive effect of aqueous ethanolic extract of C. Read More

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http://dx.doi.org/10.1186/s12906-019-2760-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888969PMC
December 2019

Experimental validation and computational modeling of anti-influenza effects of quercetin-3-O-α-L-rhamnopyranoside from indigenous south African medicinal plant Rapanea melanophloeos.

BMC Complement Altern Med 2019 Dec 2;19(1):346. Epub 2019 Dec 2.

Department of Veterinary Tropical Diseases, University of Pretoria, Pretoria, South Africa.

Background: Influenza A virus (IAV) is still a major health threat. The clinical manifestations of this infection are related to immune dysregulation, which causes morbidity and mortality. The usage of traditional medication with immunomodulatory properties against influenza infection has been increased recently. Read More

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http://dx.doi.org/10.1186/s12906-019-2774-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888925PMC
December 2019
2.020 Impact Factor

Ameliorative effects of aqueous extract of Forsythiae suspensa fruits on oxaliplatin-induced neurotoxicity in vitro and in vivo.

BMC Complement Altern Med 2019 Nov 29;19(1):339. Epub 2019 Nov 29.

Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.

Background: The dried fruits of Forsythia suspensa has generally been used to clear heat and detoxify in traditional Korean and Chinese medicine. Oxaliplatin is a first-line treatment chemotherapeutic agent for advanced colorectal cancer, but it induces peripheral neuropathy as an adverse side effect affecting the treatment regimen and the patient's quality of life. The present study was conducted to evaluate the neuroprotective effects of an aqueous extract of F. Read More

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http://dx.doi.org/10.1186/s12906-019-2761-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884752PMC
November 2019

Use of traditional and complementary medicine among Norwegian cancer patients in the seventh survey of the Tromsø study.

BMC Complement Altern Med 2019 Nov 29;19(1):341. Epub 2019 Nov 29.

Centre for Quality Improvement and Development, University Hospital of North Norway, Tromsø, Norway.

Background: Traditional and complementary medicine (T&CM) is commonly used by cancer patients in Northern Norway, in particular spiritual forms like traditional healing. T&CM is mainly used complementary to conventional cancer treatment and is rarely discussed with conventional health care providers, increasing the risk of negative interaction with conventional cancer care. The aim of this study was to investigate the use of T&CM among cancer patients in Tromsø, and to investigate the differences in T&CM use between people living with cancer, people with cancer previously, and people without a history of cancer. Read More

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http://dx.doi.org/10.1186/s12906-019-2762-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884826PMC
November 2019

Antitumor and antioxidant effects of Clinacanthus nutans Lindau in 4 T1 tumor-bearing mice.

BMC Complement Altern Med 2019 Nov 29;19(1):340. Epub 2019 Nov 29.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Background: Clinacanthus nutans Lindau (C. nutans) is a species of in Acanthaceae family and primarily used in South East Asian countries. C. Read More

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http://dx.doi.org/10.1186/s12906-019-2757-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884788PMC
November 2019
2.020 Impact Factor

1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells.

BMC Complement Altern Med 2019 Nov 29;19(1):338. Epub 2019 Nov 29.

Department of Biotechnology, National Institute of Technology, Durgapur, West Bengal, 713209, India.

Background: To investigate the potential of Catharanthus roseus leaf aqueous crude extract (CRACE) as a regulator of adipocyte development and function.

Methods: 3T3-L1 adipogenesis model was used to investigate the effect of CRACE on adipogenesis. 3T3-L1 preadipocytes (for adipogenic differentiation) and mature 3T3-L1 adipocytes (for adipocyte function) were treated with non-toxic doses of CRACE. Read More

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http://dx.doi.org/10.1186/s12906-019-2754-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883588PMC
November 2019

Tong-Xie-Yao-Fang improves intestinal permeability in diarrhoea-predominant irritable bowel syndrome rats by inhibiting the NF-κB and notch signalling pathways.

BMC Complement Altern Med 2019 Nov 27;19(1):337. Epub 2019 Nov 27.

Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, China.

Background: Tong-Xie-Yao-Fang (TXYF) has been shown to be effective in diarrhoea-predominant irritable bowel syndrome (IBS-D) patients. However, the underlying mechanism remains to be clarified. The aim of this study was to investigate the efficacy and related mechanisms of TXYF in an IBS-D rat model. Read More

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http://dx.doi.org/10.1186/s12906-019-2749-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882330PMC
November 2019

Constructing a bilingual website with validated database for Herb and Western medicine interactions using Ginseng, Ginkgo and Dong Quai as examples.

BMC Complement Altern Med 2019 Nov 27;19(1):335. Epub 2019 Nov 27.

Division of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan.

Background: Concerns have been raised regarding the efficacy and safety resulting from the potential interactions of herbs with Western medications due to the use of both herbs and Western medicine by the general public. Information obtained from the web must be critically evaluated prior to its use in making decisions.

Description: This study aimed to construct an herb-drug interaction (HDI) website (https://drug-herb-interaction. Read More

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http://dx.doi.org/10.1186/s12906-019-2731-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881993PMC
November 2019

Randomized, double-blind, placebo-controlled phase I dose escalation study of Dan Qi Tong Mai tablet in healthy volunteers.

BMC Complement Altern Med 2019 Nov 27;19(1):336. Epub 2019 Nov 27.

Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.

Background: This study aims to assess the tolerability and safety of DQTM tablet, which contains a complex mixture of Salvia miltiorrhiza salvianolic acids and Panax notoginseng saponins.

Methods: A double-blind, randomized, placebo-controlled phase I dose escalation study was conducted in 84 healthy volunteers. In a single ascending dose study, active ingredients were administered in various doses (90, 270, 540, 1080, 1800, 2880, 4320 or 5760 mg) to 60 subjects in cohorts 1-8. Read More

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http://dx.doi.org/10.1186/s12906-019-2751-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882005PMC
November 2019
2.020 Impact Factor

Thymoquinone-loaded lipid vesicles: a promising nanomedicine for psoriasis.

BMC Complement Altern Med 2019 Nov 27;19(1):334. Epub 2019 Nov 27.

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Punjab University, Chandigarh, 160014, India.

Background: Psoriasis, a recurrent, chronic inflammatory disorder of skin, is a common problem in middle age and elderly people. Thymoquinone (TQ), a lipid soluble benzoquinone is the major active ingredient of volatile oil of Nigella sativa (NS), possesses good anti-psoriatic activity. However, its hydrophobicity, poor aqueous solubility, and photosensitive nature obstructs its development. Read More

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http://dx.doi.org/10.1186/s12906-019-2675-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880584PMC
November 2019
2.020 Impact Factor

The ameliorative effect of monotropein, astragalin, and spiraeoside on oxidative stress, endoplasmic reticulum stress, and mitochondrial signaling pathway in varicocelized rats.

BMC Complement Altern Med 2019 Nov 26;19(1):333. Epub 2019 Nov 26.

Department of Urology, Institute for Medical Sciences, Chonbuk National University Medical School-Biomedical Research Institute and Clinical Trial Center for Medical Device, Chonbuk National University Hospital, Jeonju, 54907, Republic of Korea.

Background: Monotropein, astragalin, and spiraeoside (MAS) are active compounds extracted from medicinal herbs; monotropein from Morinda officinalis How (Rubiaceae), astragalin (kaempferol 3-O-glucoside) from Cuscuta chinensis Lamark (Convolvulaceae) and spiraeoside from the outer scales of Allium cepa L. (Liliceae) in a ratio of 6.69:0. Read More

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http://dx.doi.org/10.1186/s12906-019-2736-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880392PMC
November 2019
2.020 Impact Factor

Evaluation of a mouthrinse containing guava leaf extract as part of comprehensive oral care regimen- a randomized placebo-controlled clinical trial.

BMC Complement Altern Med 2019 Nov 21;19(1):327. Epub 2019 Nov 21.

Department of Biotechnology and Microbiology, Sri Dharmasthala Manjunatheshwara Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India.

Background: The control of biofilm adherence on tooth surface has always been the keystone of periodontal therapeutic systems. However, prevalence of gingivitis suggest inadequacy of self-performed oral hygiene measures and need for adjunctive aid for mechanical plaque control. Oral rinses containing chlorhexidine, has been widely used however, with certain limitations. Read More

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http://dx.doi.org/10.1186/s12906-019-2745-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873761PMC
November 2019

Development and validation of traditional & complementary medicine (TCM) scales for nurses: Using structural equation modelling (SEM).

BMC Complement Altern Med 2019 Nov 21;19(1):321. Epub 2019 Nov 21.

Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan.

Objectives: This study aimed to develop and validate scales to assess attitudes towards patient' s use of TCM (APUTCM) and to measure a communicative competence in TCM (CCTCM) among nurses.

Methods: The instrument development process was conducted from Sep 2013 to Jul 2014, using the following steps: 1) item development; 2) internal review and refinement; 3) face and content validation; 4) instrument administration to a development sample; and 5) evaluation of validity and reliability. A convenience sample was used to recruit registered and advanced practice nurses who worked in different regions throughout Taiwan. Read More

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http://dx.doi.org/10.1186/s12906-019-2733-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868815PMC
November 2019

Prevalence of and attitudes towards complementary therapy use for weight after breast cancer in Australia: a national survey.

BMC Complement Altern Med 2019 Nov 21;19(1):332. Epub 2019 Nov 21.

Department of Clinical Medicine, Faculty of Medicine and Health Science, Macquarie University, Sydney, NSW, 2109, Australia.

Background: Weight gain is common after breast cancer (BC) treatment and may increase the risk of disease recurrence. Complementary medicine (CM) use is high amongst BC patients. This paper describes the use of CM from a cross-sectional self-administered survey on prevalence and management of weight after BC. Read More

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http://dx.doi.org/10.1186/s12906-019-2747-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873562PMC
November 2019

The effects of Berberis vulgaris consumption on plasma levels of IGF-1, IGFBPs, PPAR-γ and the expression of angiogenic genes in women with benign breast disease: a randomized controlled clinical trial.

BMC Complement Altern Med 2019 Nov 21;19(1):324. Epub 2019 Nov 21.

Department of Thoracic Surgery, Faculty of Medicine, Tabriz University of Medical Sciences/ and also Surgery Ward, Nour-Nejat Hospital, Tabriz, Iran.

Background: The present study was designed to investigate the effects of Berberis vulgaris (BV) juice consumption on plasma levels of insulin-like growth factor (IGF-1), IGF-binding proteins (IGFBPs), and the expression of PPAR-γ, VEGF and HIF in women with benign breast disease.

Methods: This parallel design randomized, double-blind controlled clinical trial was conducted on 85 eligible patients diagnosed with benign breast disease. They were assigned randomly into either BV juice group (n = 44, BV juice: 480 ml/day) or placebo group (n = 41, BV placebo juice: 480 ml/day) for 8 weeks intervention. Read More

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http://dx.doi.org/10.1186/s12906-019-2715-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868871PMC
November 2019

Anti-acne vulgaris effect including skin barrier improvement and 5α-reductase inhibition by tellimagrandin I from Carpinus tschonoskii.

BMC Complement Altern Med 2019 Nov 21;19(1):323. Epub 2019 Nov 21.

Laboratory of Pharmacognosy and Natural Product derived Medicine, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea.

Background: Carpinus tschonoskii (CT) has been previously studied for various activities in the improvement of skin diseases. In the present study, we examined the in vitro anti-acne vulgaris (AV) effect of CT leaves (CTL) and tellimagrandin I (TI), one of the main ellagitannins from CT, including skin barrier improvement and 5α-reductase inhibitory activity.

Methods: To test the anti-AV activities of CTL and TI, firstly, anti-oxidative and anti-inflammatory activities including DPPH radical scavenging activity, nitric oxide (NO) inhibitory activity, and cytokines [interleukin (IL)-6 and IL-8] were tested. Read More

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http://dx.doi.org/10.1186/s12906-019-2734-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869165PMC
November 2019

Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats.

BMC Complement Altern Med 2019 Nov 21;19(1):325. Epub 2019 Nov 21.

Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, 27709, Republic of Korea.

Background: Osteoarthritis (OA) is an age-related joint disease with characteristics that involve the progressive degradation of articular cartilage and resulting chronic pain. Previously, we reported that Astragalus membranaceus and Lithospermum erythrorhizon showed significant anti-inflammatory and anti-osteoarthritis activities. The objective of this study was to examine the protective effects of ALM16, a new herbal mixture (7:3) of ethanol extracts of A. Read More

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http://dx.doi.org/10.1186/s12906-019-2746-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873692PMC
November 2019

Cytotoxic activity of crude extracts from Datura stramonium's fungal endophytes against A549 lung carcinoma and UMG87 glioblastoma cell lines and LC-QTOF-MS/MS based metabolite profiling.

BMC Complement Altern Med 2019 Nov 21;19(1):330. Epub 2019 Nov 21.

South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Tygerberg, 7505, South Africa.

Background: Endophytic fungi are a proven source of bioactive secondary metabolites that may provide lead compounds for novel drug discovery. In this study, crude extracts from fungal endophytes isolated from Datura stramonium were evaluated for cytotoxic activity on two human cancer cell lines.

Methods: Fungal endophytes were isolated from surface sterilized aerial parts of D. Read More

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http://dx.doi.org/10.1186/s12906-019-2752-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873518PMC
November 2019

Immuno-enhancement effects of Platycodon grandiflorum extracts in splenocytes and a cyclophosphamide-induced immunosuppressed rat model.

BMC Complement Altern Med 2019 Nov 21;19(1):322. Epub 2019 Nov 21.

Department of Oral Biochemistry, and Institute of Biomaterial-Implant, College of Dentistry, Wonkwang University, 460, Iksandae-ro, Iksan, Jeonbuk, 54538, Republic of Korea.

Background: Platycodon grandiflorum is a flowering plant that is used in traditional medicine for treating pulmonary and respiratory disorders. It exerts various pharmacological effects, including immunomodulatory and anti-cancer activities. The purpose of this study was to confirm the in vitro and in vivo immune-enhancing effects of P. Read More

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http://dx.doi.org/10.1186/s12906-019-2724-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868875PMC
November 2019