3,366 results match your criteria BMC Complementary and Alternative Medicine [Journal]

Dendrobium nobile Lindley and its bibenzyl component moscatilin are able to protect retinal cells from ischemia/hypoxia by dowregulating placental growth factor and upregulating Norrie disease protein.

BMC Complement Altern Med 2018 Jun 22;18(1):193. Epub 2018 Jun 22.

Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Background: Presumably, progression of developmental retinal vascular disorders is mainly driven by persistent ischemia/hypoxia. An investigation into vision-threatening retinal ischemia remains important. Our aim was to evaluate, in relation to retinal ischemia, protective effects and mechanisms of Dendrobium nobile Lindley (DNL) and its bibenzyl component moscatilin. Read More

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Prescription patterns of traditional Chinese medicine amongst Taiwanese children: a population-based cohort study.

BMC Complement Altern Med 2018 Jun 22;18(1):191. Epub 2018 Jun 22.

Department of Early Childhood Education, National Chiayi University, Chiayi, Taiwan.

Background: Traditional Chinese medicine (TCM) has been used by Chinese patients and in many other countries worldwide. However, epidemiological reports and prescription patterns on children are few.

Methods: A cohort of 178,617 children aged 18 and under from one million randomly sampled cases of the National Health Insurance Research Database was analyzed for TCM prescription patterns. Read More

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Naringin ameliorates the high glucose-induced rat mesangial cell inflammatory reaction by modulating the NLRP3 Inflammasome.

BMC Complement Altern Med 2018 Jun 22;18(1):192. Epub 2018 Jun 22.

Departments of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China.

Background: The Nucleotide binding and oligomerization domain-like receptorfamily pyrin domain-containing 3 (NLRP3)-inflammasome plays an important role in various diseases, including a variety of kidney diseases. Naringin exhibits anti-inflammatory and anti-oxidation effects among others, but its specific mechanisms are not clear. We investigated the expression of the NLRP3-inflammasome under high-glucose conditions, assessed the effects of naringin on that process, and further elucidated the role of naringin in the pathogenesis of diabetic kidney disease(DKD). Read More

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Hand-foot-mouth disease and use of steroids, intravenous immunoglobulin, and traditional Chinese herbs in a tertiary hospital in Shantou, China.

BMC Complement Altern Med 2018 Jun 20;18(1):190. Epub 2018 Jun 20.

Shantou-Oxford Clinical Research Unit, Shantou University Medical College, Shantou, Guangdong, 515040, People's Republic of China.

Background: In contrast to the guidelines of World Health Organization (WHO) and United States-Centers for Disease Control and prevention (US-CDC), the Chinese national guidelines recommend the use of steroids, intravenous immunoglobulin (IVIG), or traditional Chinese herbs (TCHs) in hand-foot-mouth disease (HFMD) management. Their use and therapeutic efficacies are, however, unclear. We aimed to describe their use in and the clinical outcomes of hospitalized HFMD cases. Read More

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Ethanol extracts from the branch of Taxillus yadoriki parasitic to Neolitsea sericea induces cyclin D1 proteasomal degradation through cyclin D1 nuclear export.

BMC Complement Altern Med 2018 Jun 20;18(1):189. Epub 2018 Jun 20.

Department of Medicinal Plant Resources, Andong National University, Andong, 36729, Republic of Korea.

Background: Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied. Thus, we elucidated the potential molecular mechanism of the branch from Taxillus yadoriki (TY) parasitic to Neolitsea sericea (NS) (TY-NS-B) for the anti-proliferative effect.

Methods: Anti-cell proliferative effect was evaluated by MTT assay. Read More

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June 2018
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Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties.

BMC Complement Altern Med 2018 Jun 18;18(1):188. Epub 2018 Jun 18.

Department of Nutrition, University of Tennessee, 1215 West Cumberland Avenue, 229 Jessie Harris Building, Knoxville, TN, 37996, USA.

Background: Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by 5'-adenosine monophosphate-activated protein kinase (AMPK), a master energy sensor of the cell. Clinically, treatment with Zyflamend and/or metformin (activators of AMPK) had benefits in castrate-resistant prostate cancer patients who no longer responded to treatment. Two predominant upstream kinases are known to activate AMPK: liver kinase B1 (LKB1), a tumor suppressor, and calcium-calmodulin kinase kinase-2 (CaMKK2), a tumor promotor over-expressed in many cancers. Read More

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June 2018
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Demand for integrative medicine among women in pregnancy and childbed: a German survey on patients' needs.

BMC Complement Altern Med 2018 Jun 15;18(1):187. Epub 2018 Jun 15.

Department of Gynecology and Obstetrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Background: Although integrative medicine is gaining increasing attention and is claiming more and more its place in modern health care, it still plays a marginal role in conventional maternity care. The present study aims to examine the patterns of Complementary and Alternative Medicine (CAM) use and the demand for integrative therapies, including CAM, relaxation therapies, nutritional counseling, and psychological assistance, among women in pregnancy and childbed.

Methods: The survey was conducted from April 2017 to July 2017 by means of a pseudo-anonymous 38-item questionnaire at the Department of Gynecology and Obstetrics, Klinikum rechts der Isar, Technical University of Munich. Read More

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Efficacy and safety of acupuncture for functional constipation: a randomised, sham-controlled pilot trial.

BMC Complement Altern Med 2018 Jun 15;18(1):186. Epub 2018 Jun 15.

KM Standards Centre, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.

Background: The prevalence of functional constipation (FC) is 3-27%, and FC has been reported to cause discomfort in daily life and various complications. The treatment for FC depends on laxatives, and thus, effective and non-toxic alternative treatments are needed.

Methods: We conducted a randomised, sham-controlled parallel-design, pilot trial. Read More

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June 2018
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Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus.

BMC Complement Altern Med 2018 Jun 15;18(1):184. Epub 2018 Jun 15.

Department of Veterinary Tropical Diseases, University of Pretoria, Pretoria, South Africa.

Background: Influenza infection is a major public health threat. The role of influenza A virus-induced inflammatory response in severe cases of this disease is widely recognized. Drug resistance and side effects of chemical treatments have been observed, resulting in increased interest in alternative use of herbal medications for prophylaxis against this infection. Read More

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The study of formulated Zoush ointment against wound infection and gene expression of virulence factors Pseudomonas aeruginosa.

BMC Complement Altern Med 2018 Jun 15;18(1):185. Epub 2018 Jun 15.

Department of Microbiology and Applied Microbiology Research Center, Systems Biology and Poisonings Institute and Department Of Microbiology, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: The outbreak of MDR and XDR strains of Pseudomonas aeruginosa and increased resistance to infection in burn patients recommend the issue of infection control. In this research, we study ZOUSH herbal ointment for gene silencing of Pseudomonas aeruginosa.

Methods: The herbal ZOUSH ointment was formulated by alcoholic extracts of plants Satureja khuzestaniea, Zataria multiflora, Mentha Mozaffariani Jamzad, honey, and polyurethane. Read More

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Placebo by proxy expectations toward acupuncture change over time: a survey comparing parental expectations to acupuncture pre- and postoperatively.

BMC Complement Altern Med 2018 Jun 14;18(1):183. Epub 2018 Jun 14.

National Research Center in Complementary and Alternative Medicine, Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, 9037, Tromsø, Norway.

Background: Patients entering a treatment have expectancy to outcome based on their previous experience, the information received, and the credibility of the treatment. Once the treatment has started, patients may detect and interpret contextual cues and somatic state. Influenced and conditioned by positive or negative interpretations, their reappraisal may improve or worsen the treatment outcome. Read More

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June 2018
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Correction to: GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia.

BMC Complement Altern Med 2018 Jun 12;18(1):182. Epub 2018 Jun 12.

Zoology Department, College of Science, King Saud University, Box 2455, Riyadh, PO, 11451, Saudi Arabia.

Following publication of the original article [1], the authors reported that there was an error in the acknowledgements. Read More

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Anti-cancer effects of Kaempferia parviflora on ovarian cancer SKOV3 cells.

BMC Complement Altern Med 2018 Jun 11;18(1):178. Epub 2018 Jun 11.

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Background: Kaempferia parviflora (KP) is an herb found in the north of Thailand and used as a folk medicine for improving vitality. Current reports have shown the anti-cancer activities of KP. However, the anti-cancer effects of KP on highly aggressive ovarian cancer have not been investigated. Read More

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Effect of neuromuscular taping on musculoskeletal disorders secondary to the use of aromatase inhibitors in breast cancer survivors: a pragmatic randomised clinical trial.

BMC Complement Altern Med 2018 Jun 11;18(1):180. Epub 2018 Jun 11.

Department of Physiotherapy, IBIMA, University of Málaga, Málaga, Spain.

Background: Aromatase inhibitors reduce breast cancer recurrence rates in postmenopausal women by about 30% compared with tamoxifen while treatments differ. Unfortunately, nearly half of women taking AIs report AI-associated arthralgia (AIA), leading to therapy abandon in on third of patients, which could lead to cancer recurrence. The purpose of the current study was to evaluate the effectiveness of Neuromuscular Taping (NMT) in the treatment of AIA in women who have been treated of BC. Read More

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Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL).

BMC Complement Altern Med 2018 Jun 11;18(1):181. Epub 2018 Jun 11.

Interdisciplinary Laboratory of Biosciences and Celiac Disease Research Center, School of Medicine, University of Brasilia, Asa Norte - CEP 70910900, Brasilia, DF, Brazil.

Background: Anacardium occidentale L phenolic lipid (LDT11) is used in traditional medicine as anti-inflammatory, astringent, antidiarrheal, anti-asthmatic and depurative. Phenolic derivatives, such as anacardic acid, extracted from cashew nut shell liquid (CNSL) have demonstrated biological and pharmacological properties, and its profile makes it a candidate for the development of new anti-inflammatory agents. The objective of the present study was to evaluate the anti-inflammatory profile of a derivative, synthesized from LDT11, on an in vitro cellular model. Read More

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Anti diabetic property of aqueous extract of Stevia rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino rats.

BMC Complement Altern Med 2018 Jun 11;18(1):179. Epub 2018 Jun 11.

Department of Food Science, Nutrition & Home Economics, Government College University, Allama Iqbal Road, Faisalabad, 38000, Pakistan.

Background: Stevia (Stevia rebaudiana) natural, non-caloric sugar substitute is rich source of pharmacologically important glycoside stevioside that is linked to the pathology and complications of diabetes.

Methods: The current research was carried out to explore the anti-diabetic effect of aqueous extract of Stevia rebaudiana leaves in albino rats. For this purpose, diabetes was induced by administration of streptozotocin (40 mg/kg body weight, intraperitoneally). Read More

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Oroxylum indicum (L.) Kurz extract inhibits adipogenesis and lipase activity in vitro.

BMC Complement Altern Med 2018 Jun 8;18(1):177. Epub 2018 Jun 8.

School of Preclinic, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 3000, Thailand.

Background: Oroxylum indicum (L.) Kurz (O. indicum) is found in Thailand. Read More

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Significance of serum ferritin as a prognostic factor in advanced hepatobiliary cancer patients treated with Korean medicine: a retrospective cohort study.

BMC Complement Altern Med 2018 Jun 7;18(1):176. Epub 2018 Jun 7.

Department of Clinical Oncology, College of Korean Medicine, Kyung Hee University Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul, 05278, Republic of Korea.

Background: Advanced hepatobiliary cancers are highly lethal cancers that require precise prediction in clinical practice. Serum ferritin level increases in malignancy and high serum ferritin level is associated with poor survival in various cancers. This study aimed to identify whether serum ferritin could independently predict the overall survival (OS) of patients with advanced hepatobiliary cancers. Read More

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June 2018
2 Reads

Correction to: GLP-I Secretion in Healthy and Diabetic Wistar Rats in Response to Aqueous Extract of Momordica charantia.

BMC Complement Altern Med 2018 Jun 6;18(1):175. Epub 2018 Jun 6.

Zoology Department, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Saudi Arabia.

Following publication of the original article [1], the authors reported that there was an error in the acknowledgements. In this Correction, the incorrect and correct acknowledgements are shown. Read More

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Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba).

BMC Complement Altern Med 2018 Jun 5;18(1):172. Epub 2018 Jun 5.

Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Rua Arcturus, 03, São Bernardo do Campo, SP, CEP 09210-180, Brazil.

Background: Trichilia catigua A. Juss. (Meliaceae) is a species known as catuaba and used in folk medicine for the treatment of fatigue, stress, impotence and memory deficit. Read More

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Phenolic contents, antimicrobial and antioxidant activity of Olea ferruginea Royle (Oleaceae).

BMC Complement Altern Med 2018 Jun 5;18(1):173. Epub 2018 Jun 5.

Department of Botany, University of Azad Jammu and Kashmir, Muzaffarabad, 13100, Pakistan.

Background: Olea ferruginea Royle (Oleaceae) has long been used as an important ethnomedicinal plant to cure fever and debility, toothache, hoarseness, throatache and skeleton disorders. In this study, phenolic contents, antimicrobial and antioxidant activities of leaf and bark extracts (chloroform, ethanol and methanol) of O. ferruginea were evaluated. Read More

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June 2018
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Evaluation of antiviral activity of Ocimum sanctum and Acacia arabica leaves extracts against H9N2 virus using embryonated chicken egg model.

BMC Complement Altern Med 2018 Jun 5;18(1):174. Epub 2018 Jun 5.

National Institute of High Security Animal Diseases, Anand Nagar, Bhopal, Madhya Pradesh, India.

Background: In the view of endemic avian influenza H9N2 infection in poultry, its zoonotic potential and emergence of antiviral resistance, two herbal plants, Ocimum sanctum and Acacia arabica, which are easily available throughout various geographical locations in India were taken up to study their antiviral activity against H9N2 virus. We evaluated antiviral efficacy of three different extracts each from leaves of O. sanctum (crude extract, terpenoid and polyphenol) and A. Read More

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Antibacterial activity and in situ efficacy of Bidens pilosa Linn and Dichrostachys cinerea Wight et Arn extracts against common diarrhoea-causing waterborne bacteria.

BMC Complement Altern Med 2018 Jun 1;18(1):171. Epub 2018 Jun 1.

Department of Biochemistry, Microbiology and Biotechnology, University of Limpopo, Private Bag X1106, Sovenga, 0727, South Africa.

Background: Bidens pilosa and Dichrostachys cinerea extracts were investigated for the antibacterial properties against waterborne diarrhoeagenic bacteria.

Methods: The plant materials were extracted using the direct and serial exhaustive methods using solvents of varying polarities, namely, hexane, dichloromethane, ethyl acetate, acetone and methanol. Qualitative phytochemical analysis and quantitative determination of total phenolic content of the leaf powders of the two plants were tested. Read More

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Herbal formula Xinshuitong capsule exerts its cardioprotective effects via mitochondria in the hypoxia-reoxygenated human cardiomyocytes.

BMC Complement Altern Med 2018 May 31;18(1):170. Epub 2018 May 31.

Fujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.

Background: The collapse of mitochondrial membrane potential (ΔΨm) resulted in the cell apoptosis and heart failure. Xinshuitong Capsule (XST) could ameliorate left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) classes and the quality of life in patients with chronic heart failure in our clinical study, however, its cardioprotective mechanisms remain unclear.

Methods: Primary human cardiomyocytes were subjected to hypoxia-reoxygenation and treated with XST200, 400 and 600 μg/ml. Read More

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In vitro antibacterial effects of Tanreqing injection combined with vancomycin or linezolid against methicillin-resistant Staphylococcus aureus.

BMC Complement Altern Med 2018 May 30;18(1):169. Epub 2018 May 30.

Experimental Research Center, China Academy of Chinese Medical Sciences, Nanxiao Road 16, Dongzhimen, Beijing, 100700, People's Republic of China.

Background: Combining conventional drugs and traditional medicine may represent a useful approach to combating antibiotic resistance, which has become a serious threat to global public health. This study aimed to evaluate the potential synergistic interactions between Tanreqing (TRQ) injection, a commercial traditional Chinese medicine formula used for the treatment of upper respiratory tract infection, and selected antibiotics used against methicillin-resistant Staphylococcus aureus (MRSA).

Methods: The minimum inhibitory concentrations (MICs) of TRQ, vancomycin and linezolid against planktonic MRSA strain were determined by the broth microdilution method. Read More

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Hindering the formation and promoting the dispersion of medical biofilms: non-lethal effects of seagrass extracts.

BMC Complement Altern Med 2018 May 30;18(1):168. Epub 2018 May 30.

Institute of Botany, Leibniz University Hannover, Herrenhäuserstr. 2, D-30419, Hannover, Germany.

Background: Biofilms have great significance in healthcare-associated infections owing to their inherent tolerance and resistance to antimicrobial therapies. New approaches to prevent and treat unwanted biofilms are urgently required. To this end, three seagrass species (Enhalus acoroides, Halophila ovalis and Halodule pinifolia) collected in Vietnam and in India were investigated for their effects in mediating non-lethal interactions on sessile bacterial (Escherichia coli) and fungal (Candida albicans) cultures. Read More

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May 2018
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Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by improving synaptic plasticity and reducing Aβ deposition.

BMC Complement Altern Med 2018 May 29;18(1):167. Epub 2018 May 29.

Department of Neurology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210008, Jiangsu, People's Republic of China.

Background: It is well known that Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition and synaptic dysfunction play important roles in the pathophysiology of Alzheimer's disease (AD). The Huatuo Zaizao pill (HT) is a Traditional Chinese Medicine (TCM) that has been used clinically for many years in China, mainly for post-stroke rehabilitation and cognitive decline; however, the mechanism of cognitive function is not clear. Read More

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May 2018
3 Reads

Associations between the use of herbal medicines and adverse pregnancy outcomes in rural Malawi: a secondary analysis of randomised controlled trial data.

BMC Complement Altern Med 2018 May 25;18(1):166. Epub 2018 May 25.

University College London, Faculty of Population Health Sciences, Institute for Global Health, 30 Guildford Street, London, WC1N 1EH, UK.

Background: The use of herbal medicines during pregnancy is very high globally and previous studies have pointed out possible associations with adverse pregnancy outcomes. Nevertheless, the safety of herbal medicines in pregnancy is under-explored in low-income countries experiencing high maternal and neonatal complications. We investigated the associations between self-reported use of Mwanamphepo (a group of herbal medicines commonly used to induce or hasten labour) and adverse maternal and neonatal outcomes in rural Malawi. Read More

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Comparison of aqueous, polyethylene glycol-aqueous and ethanolic propolis extracts: antioxidant and mitochondria modulating properties.

BMC Complement Altern Med 2018 May 23;18(1):165. Epub 2018 May 23.

Department of Drug technology and Social Pharmacy, Lithuanian university of Health Sciences, Sukileliu st. 13, LT-50166, Kaunas, Lithuania.

Background: Propolis is multicomponent substance collected by honeybees from various plants. It is known for numerous biological effects and is commonly used as ethanolic extract because most of active substances of propolis are ethanol-soluble. However, water-based propolis extracts could be applied more safely, as this solvent is more biocompatible. Read More

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May 2018
1 Read

Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism.

BMC Complement Altern Med 2018 May 22;18(1):164. Epub 2018 May 22.

Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China.

Background: Homoharringtonine (HHT) is a natural alkaloid with potent antitumor activity, but its precise mechanism of action is still poorly understood.

Methods: We examined the effect of HHT on alternative splicing of Bcl-x and Caspase 9 in various cells using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). The mechanism of HHT-affected alternative splicing in these cells was investigated by treatment with protein phosphatase inhibitors and overexpression of a protein phosphatase. Read More

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May 2018
5 Reads

Phenolics from Barleria cristata var. Alba as carcinogenesis blockers against menadione cytotoxicity through induction and protection of quinone reductase.

BMC Complement Altern Med 2018 May 22;18(1):163. Epub 2018 May 22.

Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.

Background: There are increasing interests in natural compounds for cancer chemoprevention. Blocking agents represent an important class of chemopreventive compounds. They prevent carcinogens from undergoing metabolic activation and thereby suppressing their interaction with cellular macromolecular targets. Read More

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GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia.

BMC Complement Altern Med 2018 May 18;18(1):162. Epub 2018 May 18.

Zoology Department, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Saudi Arabia.

Background: Diabetes mellitus is one of the major global health disorders increasing at an alarming rate in both developed and developing countries. The objective of this study was to assess the effect of aqueous extract of Momordica charantia (AEMC) on fasting blood glucose (FBG), tissue glycogen, glycosylated haemoglobin, plasma concentrations of insulin and GLP-1 hormone (glucagon-like peptide 1) in healthy and diabetic wistar rats.

Methods: Male Wistar rats (both normal and diabetic) were treated with AEMC by gavaging (300 mg/kg body wt/day for 28 days). Read More

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May 2018
2 Reads

Phenolic profile and biological properties of the leaves of Ficus vasta Forssk. (Moraceae) growing in Egypt.

BMC Complement Altern Med 2018 May 16;18(1):161. Epub 2018 May 16.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, Polo Annunziata, Viale Annunziata, 98168, Messina, Italy.

Background: Ficus vasta Forssk. (Moraceae) is traditionally used for the treatment of various ailments; nonetheless, this species has been poorly studied to date. This work aimed to characterize the phenolic profile and to evaluate the antioxidant and antimicrobial properties of a hydroalcoholic extract obtained from F. Read More

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May 2018
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Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola.

BMC Complement Altern Med 2018 May 16;18(1):159. Epub 2018 May 16.

Laboratory of Microbiology and Antimicrobial substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.

Background: Antimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and compounds isolated from Dissotis senegambiensis and Amphiblemma monticola, two Cameroonian Melastomataceae species traditionally used for the treatment of fever, malaria and infectious diseases.

Methods: The plant extracts were prepared by maceration in ethanol. Read More

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Five traditional Nigerian Polyherbal remedies protect against high fructose fed, Streptozotocin-induced type 2 diabetes in male Wistar rats.

BMC Complement Altern Med 2018 May 16;18(1):160. Epub 2018 May 16.

Department of Biochemistry, Benjamin S. Carson (Snr.) School of Medicine, Babcock University, Ilishan-Remo, Ogun State, PMB, Ikeja, 21244, Nigeria.

Background: This present study sought to assess the modulatory effects of five Nigerian traditional polyherbal in high fructose-fed, streptozotocin-induced (HF-STZ) Type 2 diabetes (T2D) in rats. T2D was achieved via fructose feeding (20%) ad libitum for 2 weeks and streptozotocin (STZ, 40 mg/kg) (15th Day) intraperitoneally.

Methods: Seventy-two hours after STZ injection, fourty-eight diabetic rats were divided into eight of 6 rats/group: Diabetic normal untreated, glibenclamide (GBLI, 0. Read More

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Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial.

BMC Complement Altern Med 2018 May 15;18(1):157. Epub 2018 May 15.

Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, New Territories, Hong Kong.

Background: Knee Osteoarthritis (KOA) is a very common condition with prevalence rising with age. It is a major contributor to global disability and has a large socioeconomic burden worldwide. Conservative therapies have marginal effectiveness, and surgery is reserved for severe symptomatic KOA. Read More

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May 2018
1 Read

Evidence for the use of complementary and alternative medicines during fertility treatment: a scoping review.

BMC Complement Altern Med 2018 May 15;18(1):158. Epub 2018 May 15.

Department of Psychiatry, Jewish General Hospital, 4333 Chemin de la Cote-Ste-Catherine, Room 223, Montreal, QC, H3T 1E4, Canada.

Background: Complementary and alternative medicines (CAM) are sometimes used by individuals who desire to improve the outcomes of their fertility treatment and/or mental health during fertility treatment. However, there is little comprehensive information available that analyzes various CAM methods across treatment outcomes and includes information that is published in languages other than English.

Method: This scoping review examines the evidence for 12 different CAM methods used to improve female and male fertility outcomes as well as their association with improving mental health outcomes during fertility treatment. Read More

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Prevalence of the potentially inappropriate Kampo medications to be used with caution among elderly patients taking any prescribed Kampo medications at a single centre in Japan: a retrospective cross-sectional study.

BMC Complement Altern Med 2018 May 11;18(1):155. Epub 2018 May 11.

Department of Paediatric Surgery, National Hospital Organization Tochigi Medical Center, 1-10-37, Nakatomatsuri, Utsunomiya, Tochigi, 3208580, Japan.

Background: Few studies have investigated the prevalence and characteristics of potentially inappropriate Kampo medication use among elderly ambulatory patients taking any prescribed Kampo medications.

Methods: A retrospective cross-sectional study was conducted using electronic medical records. All patients aged 65 years or older who continued visiting internal medicine physicians and were prescribed any Kampo medications from January 2015 to March 2015 were included. Read More

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May 2018
1 Read

Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats.

BMC Complement Altern Med 2018 May 11;18(1):156. Epub 2018 May 11.

Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.

Background: Oxidative stress and renal apoptosis play a significant role in the progression of diabetic nephropathy. The tubers of Pueraria tuberosa (Roxb. ex Willd. Read More

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In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris.

BMC Complement Altern Med 2018 May 10;18(1):154. Epub 2018 May 10.

Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, 21511, Egypt.

Background: Since oxidative stress and inflammation are two linked factors in the pathogenesis of several human diseases. Thus identification of effective treatment is of great importance. Edible mushroom and microalgae are rich in the effective antioxidant phytochemicals. Read More

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May 2018
2 Reads

Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway.

BMC Complement Altern Med 2018 May 9;18(1):152. Epub 2018 May 9.

Department of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.

Background: Breast cancer is the most common cancer in women and affects 1.38 million women worldwide per year. Antiestrogens such as tamoxifen, a selective estrogen receptor (ER) modulator, are widely used in clinics to treat ER-positive breast tumors. Read More

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May 2018
1 Read

Australian integrative oncology services: a mixed-method study exploring the views of cancer survivors.

BMC Complement Altern Med 2018 May 9;18(1):153. Epub 2018 May 9.

Oncology Massage Limited, Deakin, Geelong, ACT, Australia.

Background: The significant use of traditional and complementary medicine (T&CM) by cancer survivors is well documented. The aim of this study was to explore cancer survivors' views on integrating T&CM services with conventional cancer care.

Method: A mixed-method study design with an emphasis on qualitative methodology was used to conduct and analyse four focus group interviews and an on-line survey. Read More

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Sheng Jiang San, a traditional multi-herb formulation, exerts anti-influenza effects in vitro and in vivo via neuraminidase inhibition and immune regulation.

BMC Complement Altern Med 2018 May 8;18(1):150. Epub 2018 May 8.

School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong, SAR, 999077, People's Republic of China.

Background: Sheng Jiang San (SJS), a multi-herb formulation, is used in treating high fever, thirsty and anxiety in ancient China and it is sometimes used to treat seasonal influenza nowadays. However, there is no evidence-based investigation and mechanism research to support the anti-influenza efficacy of SJS. This study aims at evaluating the anti-influenza effect of SJS and investigating its possible mechanism. Read More

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Anti-stress effects of human placenta extract: possible involvement of the oxidative stress system in rats.

BMC Complement Altern Med 2018 May 8;18(1):149. Epub 2018 May 8.

Department of Science in Korean Medicine, Graduate School, College of Korean Medicine, Kyung Hee University, Seoul, 02447, South Korea.

Background: Human placenta hydrolysate (hPH) has been utilized to improve menopausal, fatigue, liver function. Its high concentration of bioactive substances is known to produce including antioxidant, anti-inflammatory and anti-nociceptive activities. However, its mechanisms of stress-induced depression remain unknown. Read More

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Artemisia Capillaris leaves inhibit cell proliferation and induce apoptosis in hepatocellular carcinoma.

BMC Complement Altern Med 2018 May 8;18(1):147. Epub 2018 May 8.

Department of Biomedical Sciences, College of Medicine, Inha University, 3-ga, Sinheung-dong, Jung-gu, Incheon, 400-712, Korea.

Background: Natural product is one of the most important sources of drugs used in pharmaceutical therapeutics. Artemisia capillaris has been traditionally used as a hepatoprotective and anti-inflammatory agent. In this study, we extracted an ethanol fraction (LAC117) from the dried leaves of Artemisia capillaris and identified its anticancer activity and mechanism of action against hepatocellular carcinoma (HCC). Read More

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A terpenoid isolated from sarang semut (Myrmecodia pendans) bulb and its potential for the inhibition and eradication of Streptococcus mutans biofilm.

BMC Complement Altern Med 2018 May 9;18(1):151. Epub 2018 May 9.

Department of Oral Biology, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.

Background: Dental caries remains a serious problem due to its detrimental effects on individual health and quality of life. The bulbs of Myrmecodia pendans (Merr & Perry), native plants of Papua, have been used as natural remedies for tumours, gout, diarrhoea, and fever. In this study, one of the active compounds of M. Read More

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Acute and chronic toxicity of a polyherbal preparation - Jueyin granules.

BMC Complement Altern Med 2018 May 8;18(1):148. Epub 2018 May 8.

Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, affiliated with Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai, 200437, China.

Background: The potential toxicity of Chinese herbal medicine has attracted more attention in recent years. Jueyin granules (JYG), a polyherbal formula, have been proven to be an effective agent for treating psoriasis in both animal models and clinical research. However, little is known about the possible acute and chronic toxicity of JYG. Read More

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May 2018
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Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway.

BMC Complement Altern Med 2018 May 4;18(1):146. Epub 2018 May 4.

Respiratory Medicine, the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, China.

Background: Fine particulate matter (PM2.5) is a major risk factor for the development and progression of atherosclerosis. Proliferation and infiltration of vascular smooth muscle cells (VSMCs) from the blood vessel media into the intima is a crucial step in the pathophysiology of atherosclerosis. Read More

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Optimizing acupuncture treatment for dry eye syndrome: a systematic review.

BMC Complement Altern Med 2018 May 3;18(1):145. Epub 2018 May 3.

Department of Ophthalmology and Otolaryngology of Korean Medicine, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul, 02453, Republic of Korea.

Background: In a former meta-analysis review, acupuncture was considered a potentially effective treatment for dry eye syndrome (DES), but there were heterogeneities among the outcomes. We updated the meta-analysis and conducted subgroup analysis to reduce the heterogeneity and suggest the most effective acupuncture method based on clinical trials.

Methods: We searched for randomized controlled trials (RCTs) in 10 databases (MEDLINE, EMBASE, CENTAL, AMED, SCOPUS, CNKI, Wangfang database, Oriental Medicine Advanced Searching Integrated System (OASIS), Koreamed, J-stage) and searched by hand to compare the effects of acupuncture and artificial tears (AT). Read More

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Use of Pinus sylvestris L. (Pinaceae), Origanum vulgare L. (Lamiaceae), and Thymus vulgaris L. (Lamiaceae) essential oils and their main components to enhance itraconazole activity against azole susceptible/not-susceptible Cryptococcus neoformans strains.

BMC Complement Altern Med 2018 May 3;18(1):143. Epub 2018 May 3.

Department of Public Health and Pediatrics, Microbiology Division, University of Torino, via Santena 9, 10126, Turin, Italy.

Background: Cryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients. In addition, the lower susceptibility of this yeast to azoles is a growing problem in health care. To date, there are very few molecules with any activity towards Cryptococcus neoformans, leading to heightened interest in finding new alternatives or adjuvants to conventional drugs for the treatment of mycosis caused by this yeast. Read More

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