3,603 results match your criteria BMC Complementary and Alternative Medicine [Journal]


What has been the impact of the Traditional Herbal Registration (THR) scheme in the UK on information provided with herbal products bought over the counter?

BMC Complement Altern Med 2019 Apr 11;19(1):85. Epub 2019 Apr 11.

School of Languages, Cultures and Societies, Centre for Translation Studies, University of Leeds, Leeds, UK.

Background: In 2011 there was a strengthening of European Union (EU) legislation on the licencing of herbal products which, in the UK, resulted in the introduction of the Traditional Herbal Registration (THR) scheme. This scheme sets out standards for the safety and quality of herbal medicines and includes the provision of information to the customer on the safe use of the product. The aim of this study is to replicate a survey undertaken in 2011, prior to the implementation of the THR scheme, and evaluate the impact of this scheme on the information provided with herbal products bought over-the-counter. Read More

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http://dx.doi.org/10.1186/s12906-019-2494-8DOI Listing

Acute liver failure associated with Fructus Psoraleae: a case report and literature review.

BMC Complement Altern Med 2019 Apr 11;19(1):84. Epub 2019 Apr 11.

Department of Dermatology, Qianfoshan Hospital, Shandong University, 16766 Jing-Shi Road, Jinan, 250014, China.

Background: Fructus Psoraleae is the seed of Psoralea corylifolia Linn. Fructus Psoraleae has been shown to be effective in treating some skin diseases, such as vitiligo. As a main ingredient in five types of herbs in the Qubaibabuqi tablet formula, Fructus Psoraleae plays an important role in the treatment of vitiligo. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2493-9DOI Listing
April 2019
2 Reads

Alternative or complementary attitudes toward alternative and complementary medicines.

BMC Complement Altern Med 2019 Apr 8;19(1):83. Epub 2019 Apr 8.

University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Martinistr. 52, D-20246, Hamburg, Germany.

Background: Integrative and complementary health approaches (ICHA) are often pursued by patients facing chronic illnesses. Most of the studies that investigated the factors associated with ICHA consumption have considered that the propensity to use ICHA is a stable or fixed characteristic of an individual. However, people may prefer using ICHA in some situations and not in others, depending on the characteristics of the illness to face. Read More

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http://dx.doi.org/10.1186/s12906-019-2490-zDOI Listing
April 2019
1 Read

Tannin profile, antioxidant properties, and antimicrobial activity of extracts from two Mediterranean species of parasitic plant Cytinus.

BMC Complement Altern Med 2019 Apr 5;19(1):82. Epub 2019 Apr 5.

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042, Monserrato (CA), Italy.

Background: Cytinus is small genus of endophytic parasitic plants distributed in South Africa, Madagascar, and in the Mediterranean region. In the latter area, two species occur, Cytinus hypocistis and C. ruber, distinguished by both morphological characters and ecological traits. Read More

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http://dx.doi.org/10.1186/s12906-019-2487-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451225PMC

Acute oral toxicity and antioxidant studies of an amine-based diselenide.

BMC Complement Altern Med 2019 Apr 3;19(1):80. Epub 2019 Apr 3.

Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil.

Background: Organochalcogen compounds have attracted the interest of a multitude of studies for their promising Pharmacological and biological activities. The antioxidant activity and acute toxicity of an organoselenium compound, 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (APDP) was determined in mice.

Methods: Mice were randomly divided into four groups, with each group comprising of seven animals. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2489-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448241PMC
April 2019
3 Reads

Traditional Chinese medicine use is associated with lower end-stage renal disease and mortality rates among patients with diabetic nephropathy: a population-based cohort study.

BMC Complement Altern Med 2019 Apr 3;19(1):81. Epub 2019 Apr 3.

Department of Mathematics, University of Toronto, Toronto, Ontario, Canada.

Background: Diabetic nephropathy (DN) is a common complication of diabetes mellitus (DM) that imposes an enormous burden on the healthcare system. Although some studies show that traditional Chinese medicine (TCM) treatments confer a protective effect on DN, the long-term impact remains unclear. This study aims to examine end-stage renal disease (ESRD) and mortality rates among TCM users with DN. Read More

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http://dx.doi.org/10.1186/s12906-019-2491-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448220PMC
April 2019
1 Read

Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway.

BMC Complement Altern Med 2019 Apr 2;19(1):79. Epub 2019 Apr 2.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, 25200, Kuantan, Pahang, Malaysia.

Background: Methanol extract (MECN) of Clinacanthus nutans Lindau leaves (family Acanthaceae) demonstrated peripherally and centrally mediated antinociceptive activity via the modulation of opioid/NO-mediated, but cGMP-independent pathway. In the present study, MECN was sequentially partitioned to obtain petroleum ether extract of C. nutans (PECN), which was subjected to antinociceptive study with aims of establishing its antinociceptive potential and determining the role of opioid receptors and L-arginine/nitric oxide/cyclic-guanosine monophosphate (L-arg/NO/cGMP) pathway in the observed antinociceptive activity. Read More

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http://dx.doi.org/10.1186/s12906-019-2486-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446312PMC
April 2019
3 Reads

Use and acceptance of complementary and alternative medicine among medical students: a cross sectional study from Palestine.

BMC Complement Altern Med 2019 Apr 2;19(1):78. Epub 2019 Apr 2.

Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.

Background: Teaching Complementary and alternative medicine (CAM) in medical schools is becoming prevalent worldwide. Few studies have been conducted to evaluate medical students' knowledge and attitude toward CAM. Therefore, this study was designed to assess CAM knowledge, attitudes, and beliefs among Palestinian medical students. Read More

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http://dx.doi.org/10.1186/s12906-019-2492-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444598PMC

Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial.

BMC Complement Altern Med 2019 Mar 29;19(1):77. Epub 2019 Mar 29.

Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Republic of Korea.

Background: Cordyceps is a traditional Chinese herb that produces various biopharmaceutical effects, including immune-enhancing effects. In this study, we prepared a Cordyceps mycelium culture extract (Paecilomyces hepiali, CBG-CS-2) to confirm its efficacy in enhancing the immune system and to evaluate its safety in healthy adults.

Methods: Healthy adults were divided into the intervention group (n = 39), who were given 1. Read More

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http://dx.doi.org/10.1186/s12906-019-2483-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441223PMC

Decreased risk of falls in patients attending music sessions on an acute geriatric ward: results from a retrospective cohort study.

BMC Complement Altern Med 2019 Mar 28;19(1):76. Epub 2019 Mar 28.

International Laboratory for Brain, Music and Sound Research (BRAMS), Montreal, Quebec, H3C 3J7, Canada.

Background: Music has been shown to improve health and quality of life. It was suggested that music may also have an impact on gait stability and fall risk. Yet, few studies have exploited music in the hospital setting, and even less so in the geriatric population. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2484-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437846PMC
March 2019
9 Reads

Announcing the affiliation between BMC Complementary and Alternative Medicine and Cochrane Complementary Medicine.

BMC Complement Altern Med 2019 Mar 29;19(1):69. Epub 2019 Mar 29.

BMC Complementary and Alternative Medicine, London, UK.

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http://dx.doi.org/10.1186/s12906-019-2480-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440073PMC

Deciphering the mechanism of Indirubin and its derivatives in the inhibition of Imatinib resistance using a "drug target prediction-gene microarray analysis-protein network construction" strategy.

BMC Complement Altern Med 2019 Mar 25;19(1):75. Epub 2019 Mar 25.

Department of Oncology, Affilited Hospital of Weifang Medical University, Weifang, 261031, Shandong, People's Republic of China.

Background: The introduction of imatinib revolutionized the treatment of chronic myeloid leukaemia (CML), substantially extending patient survival. However, imatinib resistance is currently a clinical problem for CML. It is very importantto find a strategy to inhibit imatinib resistance. Read More

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http://dx.doi.org/10.1186/s12906-019-2471-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434895PMC
March 2019
1 Read
2.020 Impact Factor

In vitro evaluation of the α-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants.

BMC Complement Altern Med 2019 Mar 25;19(1):74. Epub 2019 Mar 25.

Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, 143005, India.

Background: Different plant parts of Roylea cinerea (D. Don) Baill. (Lamiaceae), Clematis grata Wall. Read More

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http://dx.doi.org/10.1186/s12906-019-2482-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434821PMC

Effects of hydroalcoholic extract of Solidago chilensis Meyen on nociception and hypernociception in rodents.

BMC Complement Altern Med 2019 Mar 20;19(1):72. Epub 2019 Mar 20.

Department of Health Sciences, Universidade Estadual de Santa Cruz, BR-415, Rodovia Ilhéus- Itabuna, Km-16, Salobrinho, Ilhéus, Bahia, 45662-000, Brazil.

Background: Solidago chilensis (syn. microglossa) is a plant from the Asteraceae family widely distributed in South America and used to treat inflammatory diseases. In 2009, it was listed as one of the native medicinal herbal plants used in the Brazilian public health system. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2478-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427863PMC
March 2019
2 Reads

A critical integrative review of complementary medicine education research: key issues and empirical gaps.

BMC Complement Altern Med 2019 Mar 20;19(1):73. Epub 2019 Mar 20.

Distinguished Professor of Public Health, ARC Professorial Future Fellow and Director of the Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), Faculty of Health, University of Technology Ultimo, Sydney, NSW, Australia.

Background: Complementary Medicine (CM) continues to thrive across many countries. Closely related to the continuing popularity of CM has been an increased number of enrolments at CM education institutions across the public and private tertiary sectors. Despite the popularity of CM across the globe and growth in CM education/education providers, to date, there has been no critical review of peer-reviewed research examining CM education undertaken. Read More

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http://dx.doi.org/10.1186/s12906-019-2466-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427897PMC

Ocimum gratissimum Linn. Leaves reduce the key enzymes activities relevant to erectile dysfunction in isolated penile and testicular tissues of rats.

BMC Complement Altern Med 2019 Mar 19;19(1):71. Epub 2019 Mar 19.

Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, 3886, South Africa.

Background: Ocimum gratissimum L. is a medicinal plant widely grown in tropical and subtropical regions with the leaf decoction usually taken in folk medicine to enhance erectile performance in men although the probable mechanism of actions remains undetermined. This study examined the inhibitory potentials of Ocimum gratissimum leaves on some key enzymes associated with erectile dysfunction in penile and testicular tissues of the rat. Read More

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http://dx.doi.org/10.1186/s12906-019-2481-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425690PMC
March 2019
2.020 Impact Factor

Invitro synergistic activity of lactic acid bacteria against multi-drug resistant staphylococci.

BMC Complement Altern Med 2019 Mar 19;19(1):70. Epub 2019 Mar 19.

Department of Microbial Biotechnology, Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth (Deemed to be) University, Katraj, Pune, 411046, India.

Background: Multi-drug resistance in microorganisms is a serious problem at national as well as at a global level. Many researches have suggested alternatives to antibiotics with minimal or no major side effects. LAB is one of the most human-friendly probiotic strains known to mankind from times immemorial. Read More

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http://dx.doi.org/10.1186/s12906-019-2470-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425562PMC
March 2019
2 Reads

The use of maoto (Ma-Huang-Tang), a traditional Japanese Kampo medicine, to alleviate flu symptoms: a systematic review and meta-analysis.

BMC Complement Altern Med 2019 Mar 18;19(1):68. Epub 2019 Mar 18.

Center for Kampo Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Influenza is a common viral infection worldwide. Maoto (ma-huang-tang) was developed in ancient China and is used to alleviate flu symptoms. Currently, no meta-analyses have evaluated the efficacy and safety of maoto for alleviating flu symptoms. Read More

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http://dx.doi.org/10.1186/s12906-019-2474-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421694PMC

Herbal medicine use during breastfeeding: a cross-sectional study among mothers visiting public health facilities in the Western area of Sierra Leone.

BMC Complement Altern Med 2019 Mar 15;19(1):66. Epub 2019 Mar 15.

Australian Research Centre in Complementary and Integrative Medicine, Faculty of Health, University of Technology Sydney, Ultimo, Sydney, NSW, 2007, Australia.

Background: The use of medications, including herbal medicines during breastfeeding is always a concern among women. Currently, there is no published evidence on whether Sierra Leonean women use herbal medicine during breastfeeding. This study investigates the prevalence, correlates and pattern of herbal medicine use during breastfeeding. Read More

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http://dx.doi.org/10.1186/s12906-019-2479-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420723PMC
March 2019
2.020 Impact Factor

Traditional Chinese medicine formulation Yanggan Jiedu Sanjie inhibits TGF-β1-induced epithelial-mesenchymal transition and metastatic potential in human hepatocarcinoma Bel-7402 cells.

BMC Complement Altern Med 2019 Mar 15;19(1):67. Epub 2019 Mar 15.

Institute of Traditional Chinese Medicine in Oncology, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People's Republic of China.

Background: Epithelial-mesenchymal transition (EMT) is a vital process in cancer progression and metastasis. Yanggan Jiedu Sanjie (YGJDSJ) is Traditional Chinese Medicine formulation for liver cancer treatment. In the present study, we evaluated the effects of YGJDSJ on TGF-β1-induced EMT in hepatocellular carcinoma Bel-7402 cells. Read More

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http://dx.doi.org/10.1186/s12906-019-2477-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420768PMC

'We are nothing without herbs': a story of herbal remedies use during pregnancy in rural Ghana.

BMC Complement Altern Med 2019 Mar 15;19(1):65. Epub 2019 Mar 15.

Department of Geography and Rural Development, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: Herbal medicine has become the panacea for many rural pregnant women in Ghana despite the modern western antenatal care which has developed in most parts of the country. To our knowledge, previous studies investigating herbal medicine use have primarily reported general attitudes and perceptions of use, overlooking the standpoint of pregnant women and their attitudes, and utilisation of herbal medicine in Ghana. Knowledge of herbal medicine use among rural pregnant women and the potential side effects of many herbs in pregnancy are therefore limited in the country; this qualitative study attempts to address this gap by exploring the perceptions of herbal medicine usage among pregnant women in rural Ghana. Read More

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http://dx.doi.org/10.1186/s12906-019-2476-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419816PMC
March 2019
1 Read

Effects of a combination of herbal extracts (modified Ojayeonjonghwan (Wuzi Yanzong wan)) on partial urethral obstruction-induced detrusor overactivity in rats: impact on the nitric oxide pathway and oxidative stress.

BMC Complement Altern Med 2019 Mar 14;19(1):64. Epub 2019 Mar 14.

Department of Urology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: We investigated the effects of a berry mixture formula (modified Ojayeonjonghwan (Wuzi Yanzong Wan, MO formula) on detrusor overactivity (DO).

Methods: The MO formula consisted of 5 seeds obtained from 5 types of berry plants. Twenty-four Sprague-Dawley rats were randomly assigned to four groups: sham-operated (control), partial urethral obstruction-induced DO (DO group), 0. Read More

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http://dx.doi.org/10.1186/s12906-019-2467-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419416PMC
March 2019
2 Reads

Different training durations and styles of tai chi for glucose control in patients with type 2 diabetes: a systematic review and meta-analysis of controlled trials.

BMC Complement Altern Med 2019 Mar 14;19(1):63. Epub 2019 Mar 14.

Basic Medical College, Chengdu University of TCM, Chengdu, 610075, China.

Background: Physical activity is an important part of the diabetes management plan. However, the effects caused by different training durations and styles of Tai Chi have not been evaluated. We conducted an updated systematic review of the effects of Tai Chi on patients with type 2 diabetes based on different training durations and styles. Read More

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http://dx.doi.org/10.1186/s12906-019-2475-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419417PMC

Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine.

BMC Complement Altern Med 2019 Mar 12;19(1):57. Epub 2019 Mar 12.

The K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.

Background: Prolonged hyperuricemia is associated with kidney disease or gouty arthritis. Whether Yokuininto, a commercially available Kampo medicine that has been used for osteoarthritis or rheumatoid arthritis, can exhibit anti-hyperuricemic and inflammatory effects remains elusive. In the present study, Yokuininto exerts multiple homeostatic action on serum uric acid (sUA) levels by blocking pro-inflammatory cytokine activities and inducing uricosuric function with anti-renal injury functions. Read More

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http://dx.doi.org/10.1186/s12906-019-2469-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419507PMC
March 2019
1 Read

Green cardamom supplementation improves serum irisin, glucose indices, and lipid profiles in overweight or obese non-alcoholic fatty liver disease patients: a double-blind randomized placebo-controlled clinical trial.

BMC Complement Altern Med 2019 Mar 12;19(1):59. Epub 2019 Mar 12.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Background: Despite the reported health effects of cardamom on dyslipidemia, hepatomegaly, and fasting hyperglycemia, no human research has studied its potency in non-alcoholic fatty liver disease (NAFLD) as the hepatic part of metabolic syndrome. Our aim was determining the effects of green cardamom (GC) on serum glucose indices, lipids, and irisin level among overweight or obese NAFLD patients.

Methods: The place of participant recruitment was the polyclinic of the National Iranian Oil Company (NIOC) central hospital in Tehran. Read More

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http://dx.doi.org/10.1186/s12906-019-2465-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419418PMC
March 2019
2 Reads
2.020 Impact Factor

Acupuncture in improving endometrial receptivity: a systematic review and meta-analysis.

BMC Complement Altern Med 2019 Mar 13;19(1):61. Epub 2019 Mar 13.

School of Nursing, Guangzhou University of Chinese Medicine, No.232 Waihuan East Road, Higher Education Mega Center, Panyu District, Guangzhou, Postal code:510006, Guangdong, China.

Background: This systematic review aimed at summarizing and evaluating the evidence of randomized controlled trials (RCTs) using acupuncture to improve endometrial receptivity (ER).

Methods: We searched 12 databases electronically through August 2018 without language restrictions. We included RCTs of women of infertility due to low ER, and excluded infertility caused by other reasons or non-RCTs. Read More

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http://dx.doi.org/10.1186/s12906-019-2472-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417024PMC
March 2019
1 Read

Cancer patients' use of complementary and alternative medicine in Sweden: a cross-sectional study.

BMC Complement Altern Med 2019 Mar 13;19(1):62. Epub 2019 Mar 13.

Regional Cancer Center Stockholm Gotland, Box 6909, 102 39, Stockholm, Sweden.

Background: Access to and advice on Complementary and Alternative Medicine (CAM) are uncommon within Swedish conventional cancer care and little is known about cancer patients' own use of CAM. The aim of this cross-sectional study was to explore Swedish cancer patients´ patterns of CAM use, their experiences and preferences.

Methods: Questionnaires were distributed consecutively to 1297 cancer patients at a university hospital's out-patient oncology units. Read More

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http://dx.doi.org/10.1186/s12906-019-2452-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417272PMC

Manual therapy for the pediatric population: a systematic review.

BMC Complement Altern Med 2019 Mar 13;19(1):60. Epub 2019 Mar 13.

Parker University, 2540 Walnut Hill Lane, Dallas, TX, 75229, USA.

Background: This systematic review evaluates the use of manual therapy for clinical conditions in the pediatric population, assesses the methodological quality of the studies found, and synthesizes findings based on health condition. We also assessed the reporting of adverse events within the included studies and compared our conclusions to those of the UK Update report.

Methods: Six databases were searched using the following inclusion criteria: children under the age of 18 years old; treatment using manual therapy; any type of healthcare profession; published between 2001 and March 31, 2018; and English. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2447-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417069PMC
March 2019
15 Reads

Effectiveness and safety of electroacupuncture for poststroke patients with shoulder pain: study protocol for a double-center, randomized, patient- and assessor-blinded, sham-controlled, parallel, clinical trial.

BMC Complement Altern Med 2019 Mar 12;19(1):58. Epub 2019 Mar 12.

College of Korean Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.

Background: Practitioners of complementary and alternative medicine have suggested that acupuncture could alleviate poststroke shoulder pain, based on the clinical evidence. This study protocol is aimed at showing the effectiveness and safety of electroacupuncture therapy for stroke survivors with shoulder pain.

Methods: After assessing their eligibility, 60 stroke survivors with shoulder pain will be enrolled from two traditional Korean medicine hospitals and randomly divided into either the verum or the sham electroacupuncture (EA) group with a 1:1 ratio. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s12906-019-2468-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416864PMC
March 2019
2 Reads

Effect of fractioning on antibacterial activity of n-butanol fraction from Enantia chlorantha stem bark methanol extract.

BMC Complement Altern Med 2019 Mar 11;19(1):56. Epub 2019 Mar 11.

Faculty of Sciences, University of Yaoundé I, PO, Box 812, Yaoundé, Cameroon.

Background: Enantia chlorantha is a plant belonging to Annonaceae Family. The Barks and leaves are used traditionally to treat infectious diseases. Earlier studies highlighted the antibacterial activity of stem barks methanol extract. Read More

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http://dx.doi.org/10.1186/s12906-019-2459-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416886PMC
March 2019
1 Read
2.020 Impact Factor

Effects of unaltered and bioconverted mulberry leaf extracts on cellular glucose uptake and antidiabetic action in animals.

BMC Complement Altern Med 2019 Mar 6;19(1):55. Epub 2019 Mar 6.

Department of Pharmacology, Chungnam National University College of Pharmacy, 99 Daehak-ro (St.), Yuseong-gu, Daejeon, 34134, Republic of Korea.

Background: Mulberry is a Korean medicinal herb that shows effective prevention and treatment of obesity and diabetes. Bioconversion is the process of producing active ingredients from natural products using microorganisms or enzymes.

Methods: In this study, we prepared bioconverted mulberry leaf extract (BMLE) with Viscozyme L, which we tested in insulin-sensitive cells (i. Read More

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http://dx.doi.org/10.1186/s12906-019-2460-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404318PMC
March 2019
1 Read

Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression.

BMC Complement Altern Med 2019 Mar 4;19(1):54. Epub 2019 Mar 4.

Convergent Research Consortium for Immunologic disease, St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.

Background: We previously reported that tacrolimus (Tac) does not decrease T helper 17 cells (Th17) response in kidney transplantation. In this study, we evaluated whether Resveratrol (Resv) has immunosuppressive effects by decreasing Th17 responses in Tac-based immunosuppression.

Methods: We investigated the effects of Resv under Tac-treatment conditions, on CD4 T cell differentiation to Th17 cells in peripheral blood mononuclear cells (PBMCs), and proliferation of CD4 T cells co-cultured with human renal proximal tubular epithelial cells (HRPTEpiCs). Read More

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http://dx.doi.org/10.1186/s12906-019-2464-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399827PMC
March 2019
3 Reads

In vitro antioxidant and antiproliferative effect of the extracts of Ephedra chilensis K Presl aerial parts.

BMC Complement Altern Med 2019 Mar 4;19(1):53. Epub 2019 Mar 4.

Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Av. Universidad, #330, Valparaíso, Chile.

Background: Ephedra chilensis K Presl, known locally as pingo-pingo, is a Chilean endemic plant used in traditional medicine as an anti-inflammatory and used in other treatments. However, unlike for the other Ephedra species, there have been no reports on the antioxidant and cytotoxic effects of this plant. The present study aims to explore the potential applications of E. Read More

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http://dx.doi.org/10.1186/s12906-019-2462-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399944PMC
March 2019
4 Reads

Antihypertensive effects of the hydro-ethanol extract of Senecio serratuloides DC in rats.

BMC Complement Altern Med 2019 Feb 28;19(1):52. Epub 2019 Feb 28.

Department of Biological Sciences, Faculty of Natural Sciences, Walter Sisulu University, Mthatha, 5117, South Africa.

Background: Senecio serratuloides DC is used in folk medicine for treating hypertension, skin disorders, internal and external sores, rashes, burns and wounds. This study aimed at investigating the antihypertensive effects of the hydroethanol extract of S. serratuloides (HESS) in N-Nitro-L-arginine methyl ester (L-NAME) induced hypertension in rats. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2463-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394053PMC
February 2019
14 Reads

Compounds from Olea europaea and Pistacia lentiscus inhibit oral microbial growth.

BMC Complement Altern Med 2019 Feb 26;19(1):51. Epub 2019 Feb 26.

Department of Operative Dentistry and Periodontology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: In view of the increasing antibiotic resistance, the introduction of natural anti-infective agents has brought a new era in the treatment of bacterially derived oral diseases.

Methods: The aim of this study was to investigate the antimicrobial potential of five natural constituents of Olea europaea (oleuropein, maslinic acid, hydroxytyrosol, oleocanthal, oleacein) and three compounds of Pistacia lentiscus (24Z-isomasticadienolic acid, oleanolic acid, oleanonic aldehyde) against ten representative oral bacterial species and a Candida albicans strain. After the isolation and quality control of natural compounds, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) assay were performed. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-019-2461-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390541PMC
February 2019
4 Reads

Synergistic study of a Danshen (Salvia Miltiorrhizae Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) combination on cell survival in EA.hy926 cells.

BMC Complement Altern Med 2019 Feb 21;19(1):50. Epub 2019 Feb 21.

NICM Health Research Institute, Western Sydney University, Sydney, 2751, Australia.

Background: This study investigated the protective effects of the Danshen (DS) and Sanqi (SQ) herb pair on cell survival in the human cardiovascular endothelial (EA.hy926) cell line exposed to injury.

Methods: Nine combination ratios of Danshen-Sanqi extracts (DS-SQ) were screened for their protective effects in the EA. Read More

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http://dx.doi.org/10.1186/s12906-019-2458-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385400PMC
February 2019
1 Read

Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.

BMC Complement Altern Med 2019 Feb 20;19(1):49. Epub 2019 Feb 20.

Research Center for Life Science Technologies in Medicine and Environment, 31, Gwahaksandan 1-ro, 60 beon-gil, Gangseo-gu, Busan, 46742, Republic of Korea.

Background: Hordeum vulgare L (barley) contains numerous phenolic substances with proven anticancer, antioxidant and gastroprotective activities. Saccharification increases the functionality and bioavailability of these compounds thus can aid in the development of a natural product based medicine. This study aimed to investigate the possible gastroprotective effects of saccharification on the indomethacin (IND)-induced gastric ulcers in rats using Weissella cibaria- and Saccharomyces cerevisiae-triple fermented H. Read More

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http://dx.doi.org/10.1186/s12906-019-2457-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383278PMC
February 2019
1 Read

Multi-targeting chemoprevention of Chinese herb formula Yanghe Huayan decoction on experimentally induced mammary tumorigenesis.

BMC Complement Altern Med 2019 Feb 13;19(1):48. Epub 2019 Feb 13.

Affiliated Hospital of Taishan Medical University, Taian, 271000, Shandong, China.

Background: Development of safe and effective chemopreventive agents is a winning strategy in reducing the morbidity and mortality of breast cancer. The current study was to investigate the mechanism-based chemopreventive potential of a Chinese herb formula Yanghe Huayan (YHHY) Decoction on the classical 7,12-dimethylbenz(a)anthracene (DMBA) induced rat mammary carcinogenesis model.

Methods: Female Sprague-Dawley rats at 42 days of age were orally administered with a human equivalent dose of YHHY Decoction at 0. Read More

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http://dx.doi.org/10.1186/s12906-019-2456-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373088PMC
February 2019
2 Reads

Potential in vitro anti-allergic, anti-inflammatory and cytotoxic activities of ethanolic extract of Baliospermum montanum root, its major components and a validated HPLC method.

BMC Complement Altern Med 2019 Feb 12;19(1):45. Epub 2019 Feb 12.

Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani, 12120, Thailand.

Background: The root of Baliospermum montanum has been used as an ingredient of traditional Thai medicines for the treatments of several diseases including itching eczema, muscle and joint inflammation, and cancer. Few studies have been done on phytochemical components of this root. In this study, we isolated major compounds of the crude ethanolic extract of B. Read More

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http://dx.doi.org/10.1186/s12906-019-2449-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373163PMC
February 2019
2 Reads

Crude extract from Libidibia ferrea (Mart. ex. Tul.) L.P. Queiroz leaves decreased intra articular inflammation induced by zymosan in rats.

BMC Complement Altern Med 2019 Feb 12;19(1):47. Epub 2019 Feb 12.

Post Graduation in Biological Science/Post graduation program in Pharmaceutical Science/Department of Biophysics and Pharmacology, UFRN, Natal, RN, Brazil.

Background: Libidibia ferrea (L. ferrea) has been used in folk medicine to treat several conditions and to prevent cancer. This study performed a chromatographic analysis of the crude aqueous extract of Libidibia ferrea (Mart. Read More

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http://dx.doi.org/10.1186/s12906-019-2454-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373153PMC
February 2019

Improved antibacterial effects of alkali-transformed saponin from quinoa husks against halitosis-related bacteria.

BMC Complement Altern Med 2019 Feb 12;19(1):46. Epub 2019 Feb 12.

Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

Background: Quinoa is a food crop native to the Andes. The process of dehulling quinoa can produce approximately 8-12% husk, which is often discarded because it contains bitter saponin. Saponin derived from quinoa has been reported to exhibit anti-inflammatory and antifungal activity. Read More

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http://dx.doi.org/10.1186/s12906-019-2455-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373059PMC
February 2019
2.020 Impact Factor

Effect of freeze-dried Carica papaya leaf juice on inflammatory cytokines production during dengue virus infection in AG129 mice.

BMC Complement Altern Med 2019 Feb 11;19(1):44. Epub 2019 Feb 11.

Herbal Medicine Research Center, Institute for Medical Research, Ministry of Health Malaysia, 50588, Kuala Lumpur, Malaysia.

Background: Carica papaya leaves have been used for traditional treatment of dengue fever and have been reported to exhibit an immunomodulatory activity by affecting the level of cytokine production in vitro and in vivo. Due to the lack of adequate in vivo evidence in dengue disease model, the present study was initiated to screen and identify the cytokines affected by freeze-dried C. papaya leaf juice (FCPLJ) treatment in AG129 mice infected with DEN-2 dengue virus. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s12906-019-2438-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371484PMC
February 2019
3 Reads
2.020 Impact Factor

Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells.

BMC Complement Altern Med 2019 Feb 8;19(1):43. Epub 2019 Feb 8.

Department of Medicinal Plant Resources, Andong National University, 1375 Gyeongdong-ro, Andong, Gyeongsangbuk-do, 36729, Republic of Korea.

Background: Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. Read More

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http://dx.doi.org/10.1186/s12906-019-2453-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368743PMC
February 2019
1 Read

Decreased fracture incidence with traditional Chinese medicine therapy in patients with osteoporosis: a nationwide population-based cohort study.

BMC Complement Altern Med 2019 Feb 4;19(1):42. Epub 2019 Feb 4.

Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan.

Background: There are no published studies regarding the efficacy of traditional Chinese medicine (TCM) for the prevention of osteoporotic fracture. Therefore, we conducted this nationwide, population-based cohort study to investigate the probable effect of TCM to decrease the fracture rate.

Methods: We identified cases with osteoporosis and selected a comparison group that was frequency-matched according to sex, age (per 5 years), diagnosis year of osteoporosis, and index year. Read More

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http://dx.doi.org/10.1186/s12906-019-2446-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360787PMC
February 2019
1 Read

Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease.

BMC Complement Altern Med 2019 Feb 4;19(1):39. Epub 2019 Feb 4.

Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA.

Background: Alzheimer's disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. Read More

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http://dx.doi.org/10.1186/s12906-019-2451-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360737PMC
February 2019
7 Reads

Anti-borreliae efficacy of selected organic oils and fatty acids.

BMC Complement Altern Med 2019 Feb 4;19(1):40. Epub 2019 Feb 4.

Department of Infectious Diseases, Dr. Rath Research Institute, 1260 Memorex Dr., Santa Clara, CA, 95050, USA.

Background: Borrelia sp. is a causative pathogen of Lyme disease which has become a worldwide health concern. Non-toxic approaches especially directed toward latent persistent forms of this pathogen are desired. Read More

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http://dx.doi.org/10.1186/s12906-019-2450-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360722PMC
February 2019
1 Read

Effects of Radix Linderae extracts on a mouse model of diabetic bladder dysfunction in later decompensated phase.

BMC Complement Altern Med 2019 Feb 4;19(1):41. Epub 2019 Feb 4.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 51006, Guangdong, China.

Background: This study aimed to elucidate the effects and mechanisms of Radix Linderae (RL) extracts on a mouse model of diabetic bladder dysfunction (DBD), especially on later decompensated phase.

Methods: Male C57BL/6J mice were intraperitoneally injected with streptozotocin (STZ) after 4 weeks of high-fat diet (HFD) feeding. DBD mouse models (later decompensated phase) were developed by 12-weeks persistent hyperglycemia and then treated with RL extracts for 4 weeks. Read More

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http://dx.doi.org/10.1186/s12906-019-2448-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360732PMC
February 2019
1 Read
2.020 Impact Factor

Antilisterial efficacy of Lactobacillus brevis MF179529 from cow: an in vivo evidence.

BMC Complement Altern Med 2019 Feb 1;19(1):37. Epub 2019 Feb 1.

Department of Zoology, University of the Punjab , Quaid-i-Azam Campus, Lahore, Pakistan.

Background: Listeria monocytogenes is an opportunistic foodborne pathogen that causes human Listeriosis and high mortality particularly in immunocompromised individuals. Pregnant women are more prone to L. monocytogenes infection resulting in abortions. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s12906-019-2444-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359795PMC
February 2019
9 Reads

2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells.

BMC Complement Altern Med 2019 Feb 1;19(1):38. Epub 2019 Feb 1.

Ministry of Education Key Laboratory of Chinese Medicinal Resource from Lingnan, Research Center of Medicinal Plant Resource Science and Engineering, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Higher Education Mega Center, Guangzhou, 510006, China.

Background: Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding cancer stemness of HCC CSCs, which are essential for hepatoma initiation, relapse, metastasis and drug resistance. Therefore, STAT3 has been validated as a novel anti-cancer drug target and the strategies targeting HCC CSCs may bring new hopes to HCC therapy. Read More

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http://dx.doi.org/10.1186/s12906-019-2440-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359800PMC
February 2019
4 Reads

Effect of Osteoking on the osteogenic and adipogenic differentiation potential of rat bone marrow mesenchymal stem cells in vitro.

BMC Complement Altern Med 2019 Jan 31;19(1):36. Epub 2019 Jan 31.

Yunnan Key laboratory for Basic Research on Bone and Joint Diseases, Kunming University, Kunming, 650214, China.

Background: Bone damage is a condition that affects the quality of life of patients. Mesenchymal stem cells (MSCs) are important for bone repair. Osteoking is a natural compound in traditional Chinese Medicine used to treat bone diseases; however, the effect of Osteoking on the differentiation of MSCs has not been reported. Read More

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http://dx.doi.org/10.1186/s12906-019-2435-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357478PMC
January 2019
2 Reads