156,311 results match your criteria BMC Clinical Pharmacology[Journal]


Conclusions of the digital health hub of the Transform Africa Summit (2018): strong government leadership and public-private-partnerships are key prerequisites for sustainable scale up of digital health in Africa.

BMC Proc 2018 15;12(Suppl 11):17. Epub 2018 Aug 15.

WHO Country Office, Kigali, Rwanda.

Background: The use of digital technologies to improve access to health is gaining momentum in Africa. This is more pertinent with the increasing penetration of mobile phone technology and internet use, and calls for innovative strategies to support implementation of the health-related Sustainable Development Goals and Universal Health Coverage on the continent. However, the huge potential benefits of digital health to advance health services delivery in Africa is yet to be fully harnessed due to critical challenges such as proliferation of pilot projects, poor coordination, inadequate preparedness of the African health workforce for digital health, lack of interoperability and inadequate sustainable financing, among others. Read More

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Learning best-practices in journalology: course description and attendee insights into the inaugural EQUATOR Canada Publication School.

BMC Proc 2018 23;12(Suppl 10):18. Epub 2018 Aug 23.

2Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada.

Background And Purpose: Dissemination of research results is a key component of the research continuum and is commonly achieved through publication in peer-reviewed academic journals. However, issues of poor quality reporting in the research literature are well documented. A lack of formal training in journalology (i. Read More

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Validity of self-reported number of teeth in middle-aged Finnish adults: the Northern Finland Birth Cohort Study 1966.

BMC Oral Health 2018 Dec 11;18(1):210. Epub 2018 Dec 11.

Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, 90029, Oulu, Finland.

Background: We examined the validity of self-reported number of teeth in middle-aged adults by using representative cohort data to compare corresponding self-reported and clinical values.

Methods: This validity study is part of the representative 46-year-old follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966) Study. Mailed questionnaires (n = 5950) requested information on self-reported number of teeth and background variables (education, tooth brushing and smoking), while clinical oral health examinations (n = 1891) assessed the number of teeth (the 'gold standard'). Read More

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December 2018

The reproducibility of assessment of white spot lesions adjacent to orthodontic brackets, with a quantitative light induced fluorescence digital camera at different rotations of teeth - an in vitro study.

BMC Oral Health 2018 Dec 11;18(1):209. Epub 2018 Dec 11.

Department of preventive dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081, LA, Amsterdam, The Netherlands.

Background: A quantitative light-induced fluorescence digital (QLF-D) camera is able to assess demineralizations adjacent to orthodontic brackets. Rotations of teeth during and the presence of the orthodontic appliances may influence the longitudinal follow-up of such lesions over time.

Methods: Brackets were bonded on extracted teeth: 54 incisors and 31 canines. Read More

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December 2018

Identifying self-assessed competencies and areas for improvement within community pharmacist-preceptors support during pre-registration training.

BMC Med Educ 2018 Dec 11;18(1):303. Epub 2018 Dec 11.

Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10 000, Zagreb, Croatia.

Background: Competency frameworks that prompt personal and professional development have become an important component of lifelong learning; they are driven by healthcare professionals' need for development and professional recognition. This study aimed to evaluate the self-assessed competencies of community pharmacist-preceptors by using Croatian Competency Framework (CCF) and to identify competencies to be improved. The secondary aim was to explore the association between community pharmacists' characteristics (i. Read More

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December 2018

Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis.

BMC Res Notes 2018 Dec 11;11(1):879. Epub 2018 Dec 11.

Department of Anesthesiology, University Medical Center, Georg August University, Goettingen, Germany.

Objective: The mortality associated with sepsis remains unacceptably high, despite modern high-quality intensive care. Based on the results from previous studies, anaemia and its management in patients with sepsis appear to impact outcomes; however, the transfusion policy is still being debated, and the ideal approach may be extremely specific to the individual. This study aimed to investigate the long-term impact of anaemia requiring red blood cell (RBC) transfusion on mortality and disease severity in patients with sepsis. Read More

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December 2018

Data on whole genome sequencing of the oomycete Pythium insidiosum strain CBS 101555 from a horse with pythiosis in Brazil.

BMC Res Notes 2018 Dec 11;11(1):880. Epub 2018 Dec 11.

Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Objectives: The oomycete Pythium insidiosum infects humans and animals worldwide, and causes the life-threatening condition, called pythosis. Most patients lose infected organs or die from the disease. Comparative genomic analyses of different P. Read More

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December 2018

Improving palliative care with deep learning.

BMC Med Inform Decis Mak 2018 Dec 12;18(Suppl 4):122. Epub 2018 Dec 12.

Center for Biomedical Informatics Research, Stanford University, Stanford, CA, USA.

Background: Access to palliative care is a key quality metric which most healthcare organizations strive to improve. The primary challenges to increasing palliative care access are a combination of physicians over-estimating patient prognoses, and a shortage of palliative staff in general. This, in combination with treatment inertia can result in a mismatch between patient wishes, and their actual care towards the end of life. Read More

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December 2018

EHR phenotyping via jointly embedding medical concepts and words into a unified vector space.

BMC Med Inform Decis Mak 2018 Dec 12;18(Suppl 4):123. Epub 2018 Dec 12.

Department of Computer & Information Sciences, Temple University, Philadelphia, PA, USA.

Background: There has been an increasing interest in learning low-dimensional vector representations of medical concepts from Electronic Health Records (EHRs). Vector representations of medical concepts facilitate exploratory analysis and predictive modeling of EHR data to gain insights about the patterns of care and health outcomes. EHRs contain structured data such as diagnostic codes and laboratory tests, as well as unstructured free text data in form of clinical notes, which provide more detail about condition and treatment of patients. Read More

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December 2018
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Association of night eating habits with metabolic syndrome and its components: a longitudinal study.

BMC Public Health 2018 Dec 11;18(1):1366. Epub 2018 Dec 11.

Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kita-ku, Okayama, 700-8558, Japan.

Background: Night time eating is a risk factor for metabolic syndrome and obesity. The aim of this study was to investigate whether dinner immediately before bed, snacks after dinner, or combinations of both were associated with metabolic syndrome and its components in a large Japanese cohort.

Methods: We enrolled 8153 adults aged 40-54 years who participated in specific medical checkups in an Okayama facility from 2009 to 2010 and from 2013 to 2014. Read More

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December 2018

Impact of vaccine delays at the 2, 4, 6 and 12 month visits on incomplete vaccination status by 24 months of age in Quebec, Canada.

BMC Public Health 2018 Dec 11;18(1):1364. Epub 2018 Dec 11.

Institut national de santé publique du Quebec, 2400 d'Estimauville Avenue, Quebec, G1E 7G9, Canada.

Background: Timeliness in the administration of recommended vaccines is often evaluated using vaccine delays and provides more information regarding the susceptibility of children to vaccine-preventable diseases compared with vaccine coverage at a given age. The importance of on-time administration of vaccines scheduled at the first visit is well documented, but data are scarce about the impact of vaccine delays at other visits on vaccination status by 24 months of age. Using vaccine delays for the first three doses of DTaP-containing vaccines and for the first dose of measles-containing vaccines as markers of timeliness at the 2, 4, 6 and 12 month visits, we estimated the proportion of incomplete vaccination status by 24 months of age attributable to a vaccine delay at each of these visits. Read More

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December 2018
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The effects of at-home whitening on patients' oral health, psychology, and aesthetic perception.

BMC Oral Health 2018 Dec 11;18(1):208. Epub 2018 Dec 11.

Department of Restorative Dentistry, Faculty of Dentistry - University of Chile, Sergio Livingstone Pohlhammer 943, Independencia -, Santiago, Chile.

Background: The aesthetic self-perception and psychosocial impact of whitening is poorly explored in the literature; it is even less clear whether the effect of whitening may influence the psychology or social relations of patients. Therefore, the aim of this trial is to evaluate the impact of an at-home whitening procedure on patients' quality of life. Also, this study's secondary objective is the adaptation and validation of the Spanish version of the OES questionnaire (OES-SP). Read More

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December 2018
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Supra-costal tubeless percutaneous nephrolithotomy is not associated with increased complication rate: a prospective study of safety and efficacy of supra-costal versus sub-costal access.

BMC Urol 2018 Dec 11;18(1):112. Epub 2018 Dec 11.

From the Division of Urology, Department of Surgery, Changhua Christian Hospital, 135, Nanxiao St., Changhua City, Changhua County, 500, Taiwan.

Background: To assess the morbidities of tubeless percutaneous nephrolithotomy (PCNL) using supra-costal access and re-evaluate traditional concept of increased complications with supra-costal access.

Methods: From January 2010 to December 2014, a single surgeon performed 118 consecutive one-stage fluoroscopic guided PCNL's for complex renal and upper ureteral stone. Our definition for complex renal stone is defined as partial or complete staghorn stone, multiple renal stones in more than 2 calyxes, obstructive uretero-pelvic stone > 2 cm, and a renal stone in single functional kidney. Read More

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December 2018

Parental-Caregivers Perceptions Questionnaire (P-CPQ): translation and evaluation of psychometric properties of the French version of the questionnaire.

BMC Oral Health 2018 Dec 11;18(1):211. Epub 2018 Dec 11.

Universite Paris Diderot, Paris, France.

Background: The Parental-Caregivers Perceptions Questionnaire (P-CPQ) is a measure of parental/caregivers' perceptions of the impact of children's oral health on quality of life. The aim of the study was evaluate the psychometric properties of the French version of the P-CPQ.

Method: The original P-CPQ was developed in English language and has 31 items divided into four sub-scales. Read More

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December 2018
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Impact of parental migration on oral health outcomes of left-behind school-aged children in Luchuan, southern China.

BMC Oral Health 2018 Dec 11;18(1):207. Epub 2018 Dec 11.

Department of Pediatric Dentistry, College &Hospital of Stomatology, Guangxi Key Laboratory of the Rehabilitation and Reconstruction of Oral and Maxillofacial Research, Guangxi Key Laboratory of Treatment and Research for Oral and Maxillofacial Surgery Disease, Guangxi Medical University, 10 Shuangyong Road, 530021, Nanning, Guangxi Province, China.

Background: With rapid urbanization in China, an increasing number of rural adults have migrated to cities to seek job opportunities, leaving their school-aged children behind. These left-behind children (LBC) without one or both parents usually receive less attention from their caregivers. Whether the parental migration affects the children's oral health is not well understood. Read More

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December 2018

Chronic Kidney Disease stratification using office visit records: Handling data imbalance via hierarchical meta-classification.

BMC Med Inform Decis Mak 2018 Dec 12;18(Suppl 4):125. Epub 2018 Dec 12.

Computational Biomedicine Lab, Computer and Information Sciences, University of Delaware, Newark, DE, USA.

Background: Chronic Kidney Disease (CKD) is one of several conditions that affect a growing percentage of the US population; the disease is accompanied by multiple co-morbidities, and is hard to diagnose in-and-of itself. In its advanced forms it carries severe outcomes and can lead to death. It is thus important to detect the disease as early as possible, which can help devise effective intervention and treatment plan. Read More

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December 2018

Ethnic inequalities and pathways to care in psychosis in England: a systematic review and meta-analysis.

BMC Med 2018 Dec 12;16(1):223. Epub 2018 Dec 12.

Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

Background: As part of a national programme to tackle ethnic inequalities, we conducted a systematic review and meta-analysis of research on ethnic inequalities in pathways to care for adults with psychosis living in England and/or Wales.

Methods: Nine databases were searched from inception to 03.07. Read More

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December 2018

Overcoming the barriers of teaching physical examination at the bedside: more than just curriculum design.

BMC Med Educ 2018 Dec 11;18(1):302. Epub 2018 Dec 11.

Department of Medicine, The Ottawa Hospital, University of Ottawa and the Ottawa Hospital Research Institute, 501 Smyth Road CPCR L2135, Box 209, Ontario, Ottawa, K1H 8L6, Canada.

Background: Physicians in training must achieve a high degree of proficiency in performing physical examinations and must strive to become experts in the field. Concerns are emerging about physicians' abilities to perform these basic skills, essential for clinical decision making. Learning at the bedside has the potential to support skill acquisition through deliberate practice. Read More

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December 2018

Evaluating lexical similarity and modeling discrepancies in the procedure hierarchy of SNOMED CT.

Authors:
Ankur Agrawal

BMC Med Inform Decis Mak 2018 Dec 12;18(Suppl 4):88. Epub 2018 Dec 12.

Department of Computer Science, Manhattan College, New York, NY, USA.

Background: SNOMED CT is a standardized and comprehensive clinical terminology that is used in Electronic Health Records to capture, store and access clinical data of patients. Studies have, however, shown that there are inconsistencies inherent in the modeling of concepts in SNOMED CT that can have an impact on its usage to record clinical data and in clinical decision-making tools.

Methods: An effective lexical approach to identifying inconsistencies with high likelihood in the structural modeling of the concepts of SNOMED CT is discussed and assessed. Read More

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December 2018

Standardized outcome measures for pregnancy and childbirth, an ICHOM proposal.

BMC Health Serv Res 2018 Dec 11;18(1):953. Epub 2018 Dec 11.

International Consortium for Health Outcomes Measurement, Cambridge, MA, USA.

Background: Value-based health care aims to optimize the balance of patient outcomes and health care costs. To improve value in perinatal care using this strategy, standard outcomes must first be defined. The objective of this work was to define a minimum, internationally appropriate set of outcome measures for evaluating and improving perinatal care with a focus on outcomes that matter to women and their families. Read More

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December 2018

Wrist accelerometer shape feature derivation methods for assessing activities of daily living.

BMC Med Inform Decis Mak 2018 Dec 12;18(Suppl 4):124. Epub 2018 Dec 12.

Department of Computer and Information Science and Engineering, University of Florida, Gainesville, FL, USA.

Background: There has been an increasing interest in understanding the usefulness of wrist-based accelerometer data for physical activity (PA) assessment due to the ease of use and higher user compliance than other body placements. PA assessment studies have relied on machine learning methods which take accelerometer data in forms of variables, or feature vectors.

Methods: In this work, we introduce automated shape feature derivation methods to transform epochs of accelerometer data into feature vectors. Read More

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December 2018

Prevalence of and factors associated with diarrhoeal diseases among children under five in Malaysia: a cross-sectional study 2016.

BMC Public Health 2018 Dec 11;18(1):1363. Epub 2018 Dec 11.

Institute for Public Health, Ministry of Health Malaysia, Jalan Bangsar, 50590, Kuala Lumpur, Malaysia.

Background: Globally, diarrhoea is one of the major causes of morbidity and mortality among children under than 5 years of age. There is a scarcity of published data on acute gastroenteritis (AGE) prevalence in Malaysia among children. This study aims to determine factors associated with diarrhoea in children aged less than 5 years in Malaysia. Read More

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December 2018

Leveraging auxiliary measures: a deep multi-task neural network for predictive modeling in clinical research.

BMC Med Inform Decis Mak 2018 Dec 12;18(Suppl 4):126. Epub 2018 Dec 12.

Department of Emergency Medicine, Wayne State University, Detroit, MI, USA.

Background: Accurate predictive modeling in clinical research enables effective early intervention that patients are most likely to benefit from. However, due to the complex biological nature of disease progression, capturing the highly non-linear information from low-level input features is quite challenging. This requires predictive models with high-capacity. Read More

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December 2018

Expression of Rift Valley fever virus N-protein in Nicotiana benthamiana for use as a diagnostic antigen.

BMC Biotechnol 2018 Dec 11;18(1):77. Epub 2018 Dec 11.

Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, 6503200115084, Rondebosch, Cape Town, 7700, South Africa.

Background: Rift Valley fever virus (RVFV), the causative agent of Rift Valley fever, is an enveloped single-stranded negative-sense RNA virus in the genus Phlebovirus, family Bunyaviridae. The virus is spread by infected mosquitoes and affects ruminants and humans, causing abortion storms in pregnant ruminants, high neonatal mortality in animals, and morbidity and occasional fatalities in humans. The disease is endemic in parts of Africa and the Arabian Peninsula, but is described as emerging due to the wide range of mosquitoes that could spread the disease into non-endemic regions. Read More

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December 2018
2 Reads

The impact of a social norms approach on reducing levels of misperceptions around smokefree hospital entrances amongst patients, staff, and visitors of a NHS hospital: a repeated cross-sectional survey study.

BMC Public Health 2018 Dec 11;18(1):1365. Epub 2018 Dec 11.

Leeds Institute of Health Sciences, School of Medicine, University of Leeds, Leeds, UK.

Background: Smoking is a cause of avoidable morbidity and mortality. In the United Kingdom (UK) the national smoking ban inside hospital buildings is widely adhered to. There is a perception it has led to smokers congregating around hospital entrances (Selbie D. Read More

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December 2018

Can apneic oxygen insufflation become a novel lung protective ventilation strategy? A randomized, controlled, blinded, single center clinical trial.

BMC Anesthesiol 2018 Dec 11;18(1):186. Epub 2018 Dec 11.

Affiliated Hospital of Nantong University, No. 20 Xishi Road, 226001, Nantong City, Jiangsu Province, People's Republic of China.

Objective: The aim of this study was to determine whether a AOI strategy on non-ventilated lung could reduce the regional and systemic proinflammatory cytokine and oxidative stress response associated with esophagectomy, and to evaluate whether AOI can be used as a novel lung protective ventilation strategy. Its impact on oxygenation after OLV, surfactant protein A, B, C (SP-A, B, C), postoperative hospital stay and postoperative pulmonary complications (PPCs) was also evaluated.

Methods: Fifty-four adults (ASA II-III) undergoing esophagectomy with OLV were enrolled in the study. Read More

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December 2018

The impact of the tumor shrinkage by initial EGFR inhibitors according to the detection of EGFR-T790M mutation in patients with non-small cell lung cancer harboring EGFR mutations.

BMC Cancer 2018 Dec 11;18(1):1241. Epub 2018 Dec 11.

Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, little is known about the population of NSCLC patients who develop acquired resistance due to the T790M mutation. In this study, we focused on the emergence of the T790M mutation and analyzed patients refractory to initial EGFR-TKIs with successful re-biopsy samples. Read More

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December 2018
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Genetic ancestry, admixture and health determinants in Latin America.

BMC Genomics 2018 Dec 11;19(Suppl 8):861. Epub 2018 Dec 11.

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Background: Modern Latin American populations were formed via genetic admixture among ancestral source populations from Africa, the Americas and Europe. We are interested in studying how combinations of genetic ancestry in admixed Latin American populations may impact genomic determinants of health and disease. For this study, we characterized the impact of ancestry and admixture on genetic variants that underlie health- and disease-related phenotypes in population genomic samples from Colombia, Mexico, Peru, and Puerto Rico. Read More

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December 2018

Root mediated uptake of Salmonella is different from phyto-pathogen and associated with the colonization of edible organs.

BMC Plant Biol 2018 Dec 11;18(1):344. Epub 2018 Dec 11.

Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, 560012, India.

Background: Pre-harvest contamination of fruits and vegetables by Salmonella in fields is one of the causes of food-borne outbreaks. Natural openings like stomata, hydathodes and fruit cracks are known to serve as entry points. While there are reports indicating that Salmonella colonize and enter root through lateral root emerging area, further investigations regarding how the accessibility of Salmonella to lateral root is different from phyto-pathogenic bacteria, the efficacy of lateral root to facilitate entry have remained unexplored. Read More

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December 2018

An overview of co-morbidities and the development of pressure ulcers among older adults.

BMC Geriatr 2018 Dec 11;18(1):305. Epub 2018 Dec 11.

Chairman of Geriatric Division Herzog Medical Center, Jerusalem, Israel.

Background: The prevalence of pressure ulcers particularly in the frail older adult population continues to be high and very costly especially in those suffering from chronic diseases and has brought a higher awareness to comprehensive, preventive and therapeutic measures for treatment of pressure ulcers. Internal risk factors highlighted by comorbidities play a crucial role in the pathogenesis of pressure ulcers.

Main Body: Focusing on the impact of common chronic diseases (comorbidities) in aging on pressure ulcers (e. Read More

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December 2018

Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study.

BMC Nephrol 2018 Dec 11;19(1):351. Epub 2018 Dec 11.

University of the State of Rio de Janeiro, Rio de Janeiro, Brasil.

Background: Contrast enhanced ultrasonography (CEUS) assessment of kidney allografts mainly focuses on graft rejection. However, studies on delayed graft function (DGF) without acute rejection are still lacking. The aim of this study was to build a time-intensity curve (TIC) using CEUS in non-immunological DGF to understand the utility of CEUS in early transplantation. Read More

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December 2018

Altered Slc25 family gene expression as markers of mitochondrial dysfunction in brain regions under experimental mixed anxiety/depression-like disorder.

BMC Neurosci 2018 Dec 11;19(1):79. Epub 2018 Dec 11.

Laboratory of Neuropathology Modeling, The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.

Background: Development of anxiety- and depression-like states under chronic social defeat stress in mice has been shown by many experimental studies. In this article, the differentially expressed Slc25* family genes encoding mitochondrial carrier proteins were analyzed in the brain of depressive (defeated) mice versus aggressive mice winning in everyday social confrontations. The collected samples of brain regions were sequenced at JSC Genoanalytica ( http://genoanalytica. Read More

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December 2018

Use of predicted vital status to improve survival analysis of multidrug-resistant tuberculosis cohorts.

BMC Med Res Methodol 2018 Dec 11;18(1):166. Epub 2018 Dec 11.

Department of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA.

Background: Multidrug-resistant tuberculosis (MDR-TB) cohorts often lack long-term survival data, and are summarized instead by initial treatment outcomes. When using Cox proportional hazards models to analyze these cohorts, this leads to censoring subjects at the time of the initial treatment outcome, instead of them providing full survival data. This may violate the non-informative censoring assumption of the model and may produce biased effect estimates. Read More

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December 2018

Acute mesenteric venous thrombosis in a pregnant woman at 35 weeks of gestation: a case report and review of the literature.

BMC Pregnancy Childbirth 2018 Dec 11;18(1):487. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Background: Mesenteric venous thrombosis (MVT) is an infrequent thrombotic event that can cause devastating intestinal hemorrhagic ischemia. The mortality rate among patients with acute MVT ranges from 20 to 50%. Occurrence of MVT in pregnancy is quite rare. Read More

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December 2018

Effects of ranibizumab (Lucentis®) and bevacizumab (Avastin®) on human corneal endothelial cells.

BMC Ophthalmol 2018 Dec 11;18(1):316. Epub 2018 Dec 11.

Department of Ophthalmology, University of Heidelberg, Lions Eye Bank, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Ingrowth of newly formed blood and lymph vessels (angiogenesis) from the limbus region into the cornea can be treated successfully by subconjunctival application of antiangiogenic agents. Currently, there are several angiogenesis inhibitors from various manufacturers available, such as vascular endothelial growth factor (VEGF) antibodies. The aim of the study was to investigate potential cytotoxic effects of two anti-VEGF agents, ranibizumab (Lucentis®) and bevacizumab (Avastin®) on the human corneal endothelium. Read More

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December 2018
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SKA1 overexpression is associated with poor prognosis in hepatocellular carcinoma.

BMC Cancer 2018 Dec 11;18(1):1240. Epub 2018 Dec 11.

Department of Neurosurgery, First Affiliated Hospital, Zhengzhou University, 1 Jianshe Road East, Zhengzhou, 450052, Henan, China.

Background: SKA1, an important mitosis protein, has been indicated in the initiation and progression of several malignancies. However, its clinical significance in hepatocellular carcinoma (HCC) remain to be elucidated.

Methods: mRNA expression of SKA1 was examined in 126 HCC and paired non-neoplastic tissues using real-time PCR and validated in The Cancer Genome Atlas (TCGA) database. Read More

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December 2018

Hepatitis B virus infection and development of chronic kidney disease: a cohort study.

BMC Nephrol 2018 Dec 11;19(1):353. Epub 2018 Dec 11.

Departments of Epidemiology and Medicine, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

Background: The effect of chronic hepatitis B virus (HBV) infection on the risk of chronic kidney disease (CKD) is controversial. We examined the prospective association between hepatitis B surface antigen (HBsAg) serology status and incident CKD in a large cohort of men and women.

Methods: Cohort study of 299,913 adults free of CKD at baseline who underwent health screening exams between January 2002 and December 2016 in South Korea. Read More

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December 2018

Effects of time delay and body temperature on measurements of central venous oxygen saturation, venous-arterial blood carbon dioxide partial pressures difference, venous-arterial blood carbon dioxide partial pressures difference/arterial-venous oxygen difference ratio and lactate.

BMC Anesthesiol 2018 Dec 11;18(1):187. Epub 2018 Dec 11.

Department of Critical Care Medicine, the Affiliated Hospital of Qingdao University, Jiangsu Road 16, Qingdao, 266000, China.

Background: Central venous oxygen saturation (ScvO), venous-arterial blood carbon dioxide partial pressures difference (Pv-aCO), venous-arterial blood carbon dioxide partial pressures difference/arterial-venous oxygen difference ratio (Pv-aCO/Ca-vO) and lactate are important parameters employed during shock resuscitation. We designed this study to confirm the effects of time delay and body temperature on measurements of these four parameters.

Methods: Arterial and central venous blood samples were simultaneously drawn by plastic syringes via indwelling intra-arterial and central venous catheters from critically ill patients. Read More

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December 2018

Hypoglycemia secondary to factitious hyperinsulinism in a foster care adolescent - a case report of munchausen syndrome in a community hospital emergency department setting.

BMC Emerg Med 2018 Dec 11;18(1):53. Epub 2018 Dec 11.

Northeast Georgia Medical Center Barrow, 316 N Broad St, Winder, GA, 30680, USA.

Background: Factitious disorder causing hypoglycemia is a psychiatric condition in which patients deliberately use blood sugar lowering medications to cause severe symptoms for the purposes of hospitalization or other primary gains.

Case Presentation: We report a case of factitious hypoglycemia in a 19-year-old foster care adolescent female who presented to the Emergency Department with recurrent hypoglycemic episodes, to the degree that the patient required large amounts of dextrose and further management by intensive care unit hospitalization. Further inquiry revealed that the patient intentionally injected herself with large doses of insulin for the purposes of seeking hospital admission. Read More

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December 2018

BEATVIC, a body-oriented resilience therapy using kickboxing exercises for people with a psychotic disorder: a feasibility study.

BMC Psychiatry 2018 Dec 11;18(1):384. Epub 2018 Dec 11.

University of Groningen, University Medical Center Groningen, University Center of Psychiatry, Rob Giel Onderzoekcentrum, Hanzeplein 1, 9713 GZ, Groningen, Netherlands.

Background: People with a psychotic disorder have an increased risk of becoming the victim of a crime. To prevent victimization a body-oriented resilience therapy using kickboxing exercises was developed. This study aims to explore the feasibility of the therapy, to improve the therapy protocol and to explore suitable outcomes for a RCT. Read More

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December 2018

Maternal dietary consumption of legumes, vegetables and fruit during pregnancy, does it protect against small for gestational age?

BMC Pregnancy Childbirth 2018 Dec 11;18(1):486. Epub 2018 Dec 11.

Department of Health Sciences, University of Jaen, Campus de Las Lagunillas s n Edificio B3, 23071, Jaén, Spain.

Background: Different diets during pregnancy might have an impact on the health, reflected in the birthweight of newborns. The consumption of fruits and vegetables during pregnancy and the relationship with newborn health status have been studied by several authors. However, these studies have shown inconsistent results. Read More

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December 2018

Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report.

BMC Nephrol 2018 Dec 11;19(1):352. Epub 2018 Dec 11.

Intern Doctor, Internal Medicine Department, An-Najah National University Hospital, Nablus, Palestine.

Background: Baclofen is a centrally acting GABA receptor agonist and it is used widely for the treatment of spasticity, persistent hiccups and multiple sclerosis. The renal system is the main route of excretion, thus people with suboptimal renal function are prone to baclofen intoxication. Multiple doses of baclofen have been associated with toxicity, but it is very unusual that single dose can do so. Read More

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December 2018

User perceptions of avatar-based patient monitoring: a mixed qualitative and quantitative study.

BMC Anesthesiol 2018 Dec 11;18(1):188. Epub 2018 Dec 11.

Institute of Anesthesiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Background: A new patient monitoring technology called Visual Patient, which transforms numerical and waveform data into a virtual model (an avatar) of the monitored patient, has been shown to improve the perception of vital signs compared to conventional patient monitoring. In order to gain a deeper understanding of the opinions of potential future users regarding the new technology, we have analyzed the answers of two large groups of anesthetists using two different study methods.

Methods: First, we carried out a qualitative analysis guided by the "consolidated criteria for reporting qualitative research" checklist. Read More

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December 2018
1.333 Impact Factor

Structure, clustering and functional insights of repeats configurations in the upstream promoter region of the human coding genes.

BMC Genomics 2018 Dec 11;19(Suppl 8):862. Epub 2018 Dec 11.

Escuela de Ingeniería de Sistemas y Computación, Universidad del Valle, Cali, Colombia.

Background: Repetitive DNA sequences (Repeats) are significant regions in the human genome that have a specific genomic distribution, structure, and several binding sites for genome architecture and function. In consequence, the possible configurations of Repeats in specific and dynamic regions like the gene promoters could define footprints for molecular mechanisms, pathways, and cell function beyond their density in the genome. Here we explored the distribution of Repeats in the upstream promoter region of the human coding genes with the aim to identify specific configurations, clusters and functional meaning of those elements. Read More

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December 2018
3.986 Impact Factor

Higher plane of nutrition pre-weaning enhances Holstein calf mammary gland development through alterations in the parenchyma and fat pad transcriptome.

BMC Genomics 2018 Dec 11;19(1):900. Epub 2018 Dec 11.

Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, 61801, USA.

Background: To reduce costs of rearing replacement heifers, researchers have focused on decreasing age at breeding and first calving. To increase returns upon initiation of lactation the focus has been on increasing mammary development prior to onset of first lactation. Enhanced plane of nutrition pre-weaning may benefit the entire replacement heifer operation by promoting mammary gland development and greater future production. Read More

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December 2018

CLAME: a new alignment-based binning algorithm allows the genomic description of a novel Xanthomonadaceae from the Colombian Andes.

BMC Genomics 2018 Dec 11;19(Suppl 8):858. Epub 2018 Dec 11.

Grupo SISTEMIC, Ingeniería Electrónica, Facultad de Ingeniería, Universidad de Antioquia UdeA, Calle 70 No, 52-21, Medellín, Colombia.

Background: Hot spring bacteria have unique biological adaptations to survive the extreme conditions of these environments; these bacteria produce thermostable enzymes that can be used in biotechnological and industrial applications. However, sequencing these bacteria is complex, since it is not possible to culture them. As an alternative, genome shotgun sequencing of whole microbial communities can be used. Read More

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December 2018

Identification and characterization of novel conserved RNA structures in Drosophila.

BMC Genomics 2018 Dec 11;19(1):899. Epub 2018 Dec 11.

Center for non-coding RNA in Technology and Health, University of Copenhagen, Grønnegårdsvej 3, Frederiksberg C, DK-1870, Denmark.

Background: Comparative genomics approaches have facilitated the discovery of many novel non-coding and structured RNAs (ncRNAs). The increasing availability of related genomes now makes it possible to systematically search for compensatory base changes - and thus for conserved secondary structures - even in genomic regions that are poorly alignable in the primary sequence. The wealth of available transcriptome data can add valuable insight into expression and possible function for new ncRNA candidates. Read More

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December 2018

BASILIScan: a tool for high-throughput analysis of intrinsic disorder patterns in homologous proteins.

Authors:
Michal Barski

BMC Genomics 2018 Dec 11;19(1):902. Epub 2018 Dec 11.

Section of Virology, Department of Medicine, St Mary's Hospital, Imperial College London, London, W2 1PG, UK.

Background: Intrinsic structural disorder is a common property of many proteins, especially in eukaryotic and virus proteomes. The tendency of some proteins or protein regions to exist in a disordered state usually precludes their structural characterisation and renders them especially difficult for experimental handling after recombinant expression.

Results: A new intuitive, publicly-available computational resource, called BASILIScan, is presented here. Read More

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December 2018

Retraction Note: Dissecting closely linked association signals in combination with the mammalian phenotype database can identify candidate genes in dairy cattle.

BMC Genet 2018 Dec 11;19(1):111. Epub 2018 Dec 11.

Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, 8830, Tjele, Denmark.

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December 2018

Survival marker genes of colorectal cancer derived from consistent transcriptomic profiling.

BMC Genomics 2018 Dec 11;19(Suppl 8):857. Epub 2018 Dec 11.

Bioinformatics and Functional Genomics Group, Cancer Research Center (CiC-IBMCC, CSIC/USAL/IBSAL), Consejo Superior de Investigaciones Cientificas (CSIC) and University of Salamanca (USAL), Salamanca, Spain.

Background: Identification of biomarkers associated with the prognosis of different cancer subtypes is critical to achieve better therapeutic assistance. In colorectal cancer (CRC) the discovery of stable and consistent survival markers remains a challenge due to the high heterogeneity of this class of tumors. In this work, we identified a new set of gene markers for CRC associated to prognosis and risk using a large unified cohort of patients with transcriptomic profiles and survival information. Read More

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December 2018
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