281 results match your criteria BMC Clinical Pathology [Journal]


Epidemiological and histopathological profile of malignant melanoma in Malawi.

BMC Clin Pathol 2019 2;19. Epub 2019 Apr 2.

2Haukeland University Hospital, Helse Bergen, Norway.

Background: Studies on malignant melanoma have largely focused on Caucasian populations due to higher incidence in lighter-skinned individuals. While there is a well developed body of literature describing melanoma in African-Americans, much less is known about melanoma in black Africans. Prior reports have suggested that it is reportedly extremely rare in black Africans who are considered to mostly have the acral lentiginous subtype. Read More

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http://dx.doi.org/10.1186/s12907-019-0087-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444452PMC
April 2019
2 Reads

Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population.

BMC Clin Pathol 2019 18;19. Epub 2019 Mar 18.

7Cardiology and Nephrology Unit, Yaoundé General Hospital, Yaoundé, Cameroon.

Background: Serum cystatin C (SCysC) and serum creatinine (SCr) are two biomarkers used in common practice to estimate the glomerular filtration rate (GFR). For SCysC and SCr to be used in a given population, normal values need to be determined to better assess patients. This study aimed to determine SCysC and SCr reference intervals (RIs) in a Cameroonian adult population and factors susceptible of influencing them. Read More

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http://dx.doi.org/10.1186/s12907-019-0086-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423796PMC

Clinical significance of HER2 and EGFR expression in colorectal cancer patients with ovarian metastasis.

BMC Clin Pathol 2019 28;19. Epub 2019 Feb 28.

1Gastrointestinal Surgery Department, Affiliated Cancer Hospital of Guangxi Medical University, 71 Hedi Road, Nanning, Guangxi Zhuang Autonomous Region 530021 People's Republic of China.

Background: EGFR and HER2 overexpression has been reported to play important roles in colorectal cancer (CRC) development and metastasis. Ovarian metastasis is rare yet is one of the most malignant metastases of CRC, but very few studies have focused on its biological features. This study aimed to investigate the expression of EGFR and HER2 in ovarian metastases of CRC and to reveal their clinical significance. Read More

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http://dx.doi.org/10.1186/s12907-019-0085-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393975PMC
February 2019
2 Reads

Accidental intoxications in toddlers: lack of cross-reactivity of vilazodone and its urinary metabolite M17 with drug of abuse screening immunoassays.

BMC Clin Pathol 2019 18;19. Epub 2019 Feb 18.

4Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 USA.

Background: Vilazodone is an FDA approved medication used to treat major depressive disorder. The authors describe two cases of accidental vilazodone exposure in toddlers who presented with symptoms similar to amphetamine exposure and also with unexplained positive amphetamine urine immunoassay drug screens. Given a lack of published data on cross-reactivity of vilazodone and its metabolites with drug of abuse screening tests, the authors investigated drug of abuse immunoassay cross-reactivity of vilazodone and metabolites using computational and empirical approaches. Read More

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http://dx.doi.org/10.1186/s12907-019-0084-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379996PMC
February 2019

HER2 overexpression and correlation with other significant clinicopathologic parameters in Ivorian breast cancer women.

BMC Clin Pathol 2019 17;19. Epub 2019 Jan 17.

Department of Anatomic Pathology, School of Medicine, Alassane Ouattara University, BP V 18 Bouake, Bouake, Ivory Coast.

Background: The overexpression of HER2 is associated with worse prognosis of breast cancer which responds favourably to anti-HER2 therapy. The objective of this study was to determine the frequency of HER2 and its association with clinicopathologic factors in breast cancer in Ivory Coast.

Methods: The study included 608 patients who were histologically diagnosed with invasive primary breast carcinoma. Read More

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http://dx.doi.org/10.1186/s12907-018-0081-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335844PMC
January 2019
1 Read

A case report of iatrogenic deterioration of yet undiagnosed Rhombencephalitis; always be careful with corticoids.

BMC Clin Pathol 2018 27;18:15. Epub 2018 Dec 27.

Erasmus Medical Center Rotterdam The Netherlands, Intensive Care Unit - Adults, Rotterdam, The Netherlands.

Background: is a bacterium present in some food products. It is rarely the cause of Rhombencephalitis in immunocompetent patients.

Case Presentation: We report a case of an immunocompetent patient, presenting with progressive perioral numbness and dizziness. Read More

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http://dx.doi.org/10.1186/s12907-018-0083-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307248PMC
December 2018
2 Reads

BCL-2 expression aids in the immunohistochemical prediction of the Oncotype DX breast cancer recurrence score.

BMC Clin Pathol 2018 18;18:14. Epub 2018 Dec 18.

2Cancer Treatment Centers of America, Eastern Regional Medical Center, Department of Pathology & Laboratory Medicine, 1331 E. Wyoming Ave, Philadelphia, PA 19124 USA.

Background: The development of molecular techniques to estimate the risk of breast cancer recurrence has been a significant addition to the suite of tools available to pathologists and breast oncologists. It has previously been shown that immunohistochemistry can provide a surrogate measure of tumor recurrence risk, effectively providing a less expensive and more rapid estimate of risk without the need for send-out. However, concordance between gene expression-based and immunohistochemistry-based approaches has been modest, making it difficult to determine when one approach can serve as an adequate substitute for the other. Read More

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https://bmcclinpathol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12907-018-0082-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299556PMC
December 2018
6 Reads

Urinary schistosomiasis: report of case diagnosed in bladder biopsy.

BMC Clin Pathol 2018 28;18:13. Epub 2018 Nov 28.

Department of Pathology, Military General Hospital Mohammed V, Mohammed V- Souissi University, Hay Riad, 10000 Rabat, Morocco.

Background: Urinary schistosomiasis is a common parasitic disease in endemic countries.

Case Presentation: We report the case of a patient who was on a working trip to Mauritania. This parasitosis, suspected in the presence of hematuria and the notion of stay in an endemic zone, was confirmed by the presence of Schistosoma heamatobium eggs during the histological examination of the bladder biopsy performed after cystoscopy, highlighting a bilharzial granuloma and of course, the diagnosis was confirmed by the presence of eggs during the direct examination of the freshly collected urine. Read More

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http://dx.doi.org/10.1186/s12907-018-0080-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263537PMC
November 2018
3 Reads

Circulating free plasma tumor DNA in patients with advanced gastric cancer receiving systemic chemotherapy.

BMC Clin Pathol 2018 26;18:12. Epub 2018 Nov 26.

1Discipline of Hematology and Oncology at ABC Foundation School of Medicine, Santo André, Brazil.

Background: Advanced gastric cancers are usually associated with incurable conditions for which systemic treatments are indicated. Recent studies suggest that circulating cell-free plasma DNA of tumour origin (tDNA) is a promising non-invasive biomarker that can be used to predict the prognosis and monitor the efficacy of systemic treatments in patients with certain types of cancer. We conducted a pilot study to analyse the potential role of tDNA as a biomarker in patients with advanced gastric cancer. Read More

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http://dx.doi.org/10.1186/s12907-018-0079-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258437PMC
November 2018
8 Reads

Pelvic radiotherapy for cervical cancer affects importantly the reproducibility of cytological alterations evaluation.

BMC Clin Pathol 2018 5;18:11. Epub 2018 Oct 5.

3Department of Gynecologic Oncology, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331 - Dr. Paulo Prata, Barretos, 14784-400 São Paulo Brazil.

Background: to evaluate the intraobserver and interobserver reproducibility of cervical cytopathology according to previous knowledge of whether patients received radiotherapy (RT) treatment or not.

Methods: The study analyzed a sample of 95 cervix cytological slides; 24 with cytological abnormalities (CA) and presence of RT; 21 without CA and presence of RT; 25 without CA and without previous RT; 25 with CA and without previous RT. Two cytopathology (CP) evaluations of the slides were carried out. Read More

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https://bmcclinpathol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12907-018-0078-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173841PMC
October 2018
16 Reads

Biphasic low-grade nasopharyngeal papillary adenocarcinoma: a case report and literature review.

BMC Clin Pathol 2018 4;18:10. Epub 2018 Oct 4.

1Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611 Japan.

Background: Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is distinctly rare. We report a patient with a uniquely biphasic LGNPPA; additionally, we review similar tumors reported in the literature.

Case Presentation: A 56-year-old man presented with an asymptomatic pedunculated tumor in the vault of the nasopharynx, at the junction of the nasal septum and the roof, which was discovered during screening for laryngeal cancer. Read More

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https://bmcclinpathol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12907-018-0076-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172832PMC
October 2018
17 Reads

Prognostic significance of p16 & p53 immunohistochemical expression in triple negative breast cancer.

BMC Clin Pathol 2018 3;18. Epub 2018 Oct 3.

4Brown University, Providence, RI USA.

Background: p16 and p53 genes are frequently mutated in triple negative breast cancer & prognostic value of these mutations have been shown; however, their role as immunohistochemical overexpression has not been fully validated. Therefore we aimed to evaluate the association of p16 and p53 overexpression in triple negative breast cancer with various prognostic parameters.

Methods: Total 150 cases of triple negative breast cancers were selected from records of pathology department archives that underwent surgeries at Liaquat National hospital, Karachi from January 2008 till December 2013. Read More

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http://dx.doi.org/10.1186/s12907-018-0077-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171321PMC
October 2018
5 Reads

Primary cutaneous nocardiosis: a diagnosis of consideration in a renal transplant recipient.

BMC Clin Pathol 2018 1;18. Epub 2018 Oct 1.

3Department of Nephrology and Renal Transplantation Medicine, Grande International Hospital, Kathmandu, Nepal.

Background: The cutaneous nocardiosis remains a diagnostic challenge: similar clinical presentations as of cutaneous diseases with different etiology-and the inherent difficulty in cultivating the pathogen.

Case Presentation: Herein, we describe a case of primary cutaneous nocardiosis in a renal transplant recipient; treated with anti-tubercular drugs due to misdiagnosis of cutaneous tuberculosis. On clinical examinations, a few red erythematous papules with erosions and crusting seen, over prior surgery scar of renal transplant. Read More

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https://bmcclinpathol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12907-018-0075-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167885PMC
October 2018
6 Reads

Diagnostic guidelines for the histological particle algorithm in the periprosthetic neo-synovial tissue.

BMC Clin Pathol 2018 25;18. Epub 2018 Aug 25.

MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany.

Background: The identification of implant wear particles and non-implant related particles and the characterization of the inflammatory responses in the periprosthetic neo-synovial membrane, bone, and the synovial-like interface membrane (SLIM) play an important role for the evaluation of clinical outcome, correlation with radiological and implant retrieval studies, and understanding of the biological pathways contributing to implant failures in joint arthroplasty. The purpose of this study is to present a comprehensive histological particle algorithm (HPA) as a practical guide to particle identification at routine light microscopy examination.

Methods: The cases used for particle analysis were selected retrospectively from the archives of two institutions and were representative of the implant wear and non-implant related particle spectrum. Read More

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https://bmcclinpathol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12907-018-0074-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109269PMC
August 2018
18 Reads

Diagnostic pitfall: primary myoepithelial carcinoma of the lacrimal gland, case report and literature review.

BMC Clin Pathol 2018 2;18. Epub 2018 Aug 2.

1Department of Pathology, Specialties Hospital, Ibn Sina University Hospital, Rabat, Morocco.

Background: In lacrimal gland, lymphomas and inflammatory lesions predominate. Primary epithelial tumours represent less than 30% of lacrimal gland lesions. Myoepithelial carcinoma of lacrimal gland is rare. Read More

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https://bmcclinpathol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12907-018-0073-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090953PMC
August 2018
7 Reads

B-chronic lymphocytic leukemia showed triple transformation, to diffuse large B cell, CD20-negative, and T-cell neoplasm during ofatumumab treatment: a case report.

BMC Clin Pathol 2018 22;18. Epub 2018 May 22.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-town, Kita-county, Kagawa, 761-0793 Japan.

Background: Chronic lymphocytic leukemia (CLL) is a mature lymphoid neoplasm currently categorized as an indolent type of malignant lymphoma. CLL progresses slowly over years, but it eventually transforms to a more aggressive lymphoma such as the diffuse large B-cell (DLBCL) type, also known as Richter's syndrome.

Case Presentation: We treated a 69-year-old Japanese male who was histologically diagnosed with Richter's syndrome after 6 years of CLL. Read More

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http://dx.doi.org/10.1186/s12907-018-0072-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964677PMC
May 2018
4 Reads

Evaluation of SD BIOLINE Ag rapid test against double ELISA with SD Ag ELISA and EZ-STEP Ag ELISA tests.

BMC Clin Pathol 2018 5;18. Epub 2018 Mar 5.

1Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O.BOX 196, Gondar, Ethiopia.

Background: antibody titters fall very slowly even after successful treatment. Therefore, tests detecting antibody lack specificity and sensitivity. On the other hand, stool antigen tests are reported as an alternative assay because of their reliability and simplicity. Read More

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http://dx.doi.org/10.1186/s12907-018-0071-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836355PMC
March 2018
17 Reads

Primary hepatic neuroendocrine carcinoma: report of two cases and literature review.

BMC Clin Pathol 2018 1;18. Epub 2018 Mar 1.

2Department of Biostatistics, Yale University, New Haven, CT 06511 USA.

Background: Primary hepatic neuroendocrine carcinoma (PHNEC) is extremely rare. The diagnosis of PHNEC remains challenging-partly due to its rarity, and partly due to its lack of unique clinical features. Available treatment options for PHNEC include surgical resection of the liver tumor(s), radiotherapy, liver transplant, transcatheter arterial chemoembolization (TACE), and administration of somatostatin analogues. Read More

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http://dx.doi.org/10.1186/s12907-018-0070-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831736PMC
March 2018
14 Reads
1 Citation

The expression of MDM2 in gastrointestinal stromal tumors: immunohistochemical analysis of 35 cases.

BMC Clin Pathol 2018 24;18. Epub 2018 Jan 24.

1Department of pathology, Hassan II university hospital, Fès, Morocco.

Background: Gastrointestinal stromal tumors (GIST) are the most common primary mesenchymal tumors of the digestive system. The assessment of their biological behavior still remains a scientific challenge. To date, there are no well-established biological prognostic markers of GIST. Read More

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http://dx.doi.org/10.1186/s12907-018-0069-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781285PMC
January 2018
9 Reads

Comparison of a microsphere-based platform with a multiplex flow cytometric assay for determination of circulating cytokines in the mouse.

BMC Clin Pathol 2018 6;18. Epub 2018 Jan 6.

Sinclair Research Center, LLC, 562 State Rd. DD, Auxvasse, MO 65231 USA.

Background: Measuring expression profiles of inflammatory biomarkers is important in monitoring the polarization of immune responses; therefore, results should be independent of quantitation methods if they are to be accepted as validated clinical pathology biomarkers. To evaluate effects of differing quantitation methods, the seven major circulating Th1/Th2/Th17 cytokines interleukin 2 (IL-2), interferon γ (IFN-γ), tumor necrosis factor α (TNF-α), IL-4, IL-6, IL-10 and IL-17A were quantified in plasma of lipopolysaccharide (LPS)-treated mice with two different multiplex platforms.

Methods: Female C57BL6 mice were treated orally with vehicle or dexamethasone, followed by LPS intravenously. Read More

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http://dx.doi.org/10.1186/s12907-017-0068-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756325PMC
January 2018
6 Reads

Impending relapse of myelodysplastic syndrome after allogeneic transplant is difficult to diagnose and requires a multi-modal approach.

BMC Clin Pathol 2017 28;17:28. Epub 2017 Dec 28.

Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN USA.

Background: The only potentially curative therapy for myelodysplastic syndrome is allogeneic hematopoietic cell transplant; unfortunately, there is a high relapse rate. The objective of this study was to perform a detailed clinicopathologic study of patients with relapsed myeloid neoplasm following allogeneic hematopoietic cell transplant for myelodysplastic syndrome.

Methods: Pre-transplant, post-transplant, and relapse bone marrow and peripheral blood morphologic features (including dysplasia) were retrospectively evaluated by study authors. Read More

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http://dx.doi.org/10.1186/s12907-017-0066-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746015PMC
December 2017
7 Reads

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer.

BMC Clin Pathol 2017 28;17:27. Epub 2017 Dec 28.

Gynaecological Oncology Research Group, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Level 5 - Research, St Mary's Hospital, Oxford Road, Manchester, M13 9WL UK.

Background: Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options. Altered energy metabolism is a hallmark of malignancy. Read More

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http://dx.doi.org/10.1186/s12907-017-0067-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745908PMC
December 2017
12 Reads

Elevation of small, dense low density lipoprotein cholesterol-a possible antecedent of atherogenic lipoprotein phenotype in type 2 diabetes patients in Jos, North-Central Nigeria.

BMC Clin Pathol 2017 6;17:26. Epub 2017 Dec 6.

Department of Chemical Pathology, University of Jos Teaching Hospital, Jos, Plateau State Nigeria.

Background: The global prevalence of type 2 diabetes is increasing. Dyslipidaemia is a known complication of diabetes mellitus manifesting frequently as cardiovascular diseases and stoke. Elevation of small, dense low density lipoprotein has been recognised as a component of the atherogenic lipoprotein phenotype associated with cardiovascular complications. Read More

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https://bmcclinpathol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12907-017-0065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718080PMC
December 2017
12 Reads

Diagnostic accuracy of touch imprint cytology for head and neck malignancies: a useful intra-operative tool in resource limited countries.

BMC Clin Pathol 2017 25;17:25. Epub 2017 Nov 25.

Kandahar University, Kandahar, Afghanistan.

Background: Intraoperative consultation is an important tool for the evaluation of the upper aerodigestive tract (UAT) malignancies. Although frozen section analysis is a preferred method of intra-operative consultation, however in resource limited countries like Pakistan, this facility is not available in most institutes; therefore, we aimed to evaluate the diagnostic accuracy of touch imprint cytology for UAT malignancies using histopathology of the same tissue as gold standard.

Methods: The study involved 70 cases of UAT lesions operated during the study period. Read More

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http://dx.doi.org/10.1186/s12907-017-0063-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702091PMC
November 2017
26 Reads

Lymphoepithelial carcinoma: a case report of a rare tumor of the larynx.

BMC Clin Pathol 2017 25;17:24. Epub 2017 Nov 25.

Department of Pathology, Hassan II University Hospital, 30000 Fez, Morocco.

Background: Lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. It is extremely rare in the larynx and should be distinguished from squamous cell carcinoma. Therefore, it must be known by clinicians, pathologists and oncologists. Read More

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http://dx.doi.org/10.1186/s12907-017-0061-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702189PMC
November 2017
11 Reads

Posterior cerebral fossa medulloepithelioma: report of a case.

BMC Clin Pathol 2017 21;17:23. Epub 2017 Nov 21.

Radiotherapy department - Oncology and hematology center, Mohammed VI University Hospital, Marrakech, Morocco.

Background: Medulloepithelioma is a rare primitive neuroectodermal tumor of the central nervous system, usually developing in childhood. Due to its rarity, the optimal management is still unknown. The prognosis is poor, especially when resection is incomplete. Read More

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http://dx.doi.org/10.1186/s12907-017-0064-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697137PMC
November 2017
15 Reads

Solitary fibrous tumor occurring in the parotid gland: a case report.

BMC Clin Pathol 2017 21;17:22. Epub 2017 Nov 21.

Department of Pathology, Hospital of Specialities, Rabat, Morocco.

Background: Solitary fibrous tumor is an uncommon spindle cell neoplasm of unknown origin. It has been reported in many anatomic sites, with a rare occurrence in the head and neck region. Solitary fibrous tumors of the parotid gland are exceptional; their clinical and radiologic features are non specific, often mimicking more common salivary gland tumors. Read More

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http://dx.doi.org/10.1186/s12907-017-0062-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697096PMC
November 2017
15 Reads

De novo acute lymphoblastic leukemia-like disease of high grade B-cell lymphoma with and and/or rearrangements: a case report and literature review.

BMC Clin Pathol 2017 9;17:21. Epub 2017 Nov 9.

Division of Hematology & Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511 Japan.

Background: B-cell lymphomas harboring the 8q24/ plus 18q21/ translocations are now referred to as high grade B-cell lymphoma with and and/or rearrangements (HGBL-MBR). Although HGBL-MBR is frequently found in cases with diffuse large B-cell lymphoma or Burkitt lymphoma-like B-cell lymphoma, acute lymphoblastic leukemia (ALL)-like disease of HGBL-MBR (AL-HGBL-MBR) has been reported incidentally.

Case Presentation: A 69-year-old Japanese woman developed remittent fever and increasing systemic bone pain. Read More

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http://dx.doi.org/10.1186/s12907-017-0060-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679186PMC
November 2017
12 Reads

Primary hyperoxaluria detected by bone marrow biopsy: case report.

BMC Clin Pathol 2017 20;17:20. Epub 2017 Sep 20.

Department of Pathology, FMFM-UCAM-CHU Mohammed VI-50 Assif, 40000 Marrakech, Morocco.

Background: Primary hyperoxaluria is a rare disease with an estimated prevalence of 1 to 3 cases per million. It is due to a hepatic enzyme deficiency responsible for an endogenous overproduction of oxalate. Oxalate crystals commonly deposit in the kidney and more rarely in bone marrow. Read More

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http://dx.doi.org/10.1186/s12907-017-0059-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607598PMC
September 2017
7 Reads

Biochemical and histological alterations induced by the smoke of allethrin based mosquito coil on mice model.

BMC Clin Pathol 2017 30;17:19. Epub 2017 Aug 30.

Protein Science Lab, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205 Bangladesh.

Background: Mosquito coil (MC) emits insecticide upon burning which provides limited protection against lethal mosquito borne diseases. However, apart from killing the insect, toxicities associated with the inhalation of these insecticides poses severe health hazards. However, the use of MC is increasing day by day in third world countries in particular but, yet to receive enough attention of both policy maker and general public. Read More

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http://bmcclinpathol.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12907-017-0057-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577793PMC
August 2017
13 Reads

Accuracy of cervical cytology: comparison of diagnoses of 100 Pap smears read by four pathologists at three hospitals in Norway.

BMC Clin Pathol 2017 29;17:18. Epub 2017 Aug 29.

Nordlandssykehuset HF, Department of Pathology, Bodø, Norway.

Background: Cervical cancer can be prevented by early detection and treatment for precancerous lesions. Since 1995, there has been a national cervical cancer screening program in Norway, where women aged 25-69 years are recommended to take Pap smears every three years. There are 17 cytology laboratories covering a population of 5 million people. Read More

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http://dx.doi.org/10.1186/s12907-017-0058-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576325PMC
August 2017
9 Reads

Primary breast angiosarcoma: a rare presentation of rare tumor - case report.

BMC Clin Pathol 2017 29;17:17. Epub 2017 Aug 29.

Pathology department - Ar Razi Hospital, UCH Mohammed VI, Marrakech, Morocco.

Background: Primary breast angiosarcoma is defined as malignant proliferation showing endothelial differentiation. It is a very rare tumour (0.05% of primary mammary cancers), whose diagnosis can be difficult. Read More

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http://dx.doi.org/10.1186/s12907-017-0055-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576236PMC
August 2017
17 Reads

Cerebrospinal fluid pleocytosis level as a diagnostic predictor? A cross-sectional study.

BMC Clin Pathol 2017 24;17:15. Epub 2017 Aug 24.

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.

Background: Lumbar puncture with quantification of leukocytes and differential count of cellular subsets in the cerebrospinal fluid is a standard procedure in cases of suspected neuroinfectious conditions. However, a number of non-infectious causes may result in a low leukocyte number (0-1000 cells/ml). We wanted to assess the diagnostic diversity of unselected adult patients with pleocytosis in the cerebrospinal fluid. Read More

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http://dx.doi.org/10.1186/s12907-017-0053-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571639PMC
August 2017
10 Reads

Primary ovarian angiosarcoma in a 12- year -old girl: a case report of an exceptional localization in a context of limited resources country.

BMC Clin Pathol 2017 24;17:16. Epub 2017 Aug 24.

Department of Pathology, University Teaching Hospital, BP 1515 Lomé, Togo.

Background: Ovarian sarcomas represent less than 1% of all ovary cancers and usually are frequent in adults. Primary angiosarcomas are exceptional in the ovaries within children.

Case Presentation: We reported a case of primary ovarian angiosarcoma in a 12-year-old girl in a resource-constrained context. Read More

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http://dx.doi.org/10.1186/s12907-017-0056-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571497PMC
August 2017
49 Reads

The use of dielectric blood coagulometry in the evaluation of coagulability in patients with peripheral arterial disease.

BMC Clin Pathol 2017 23;17:14. Epub 2017 Aug 23.

Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519 Japan.

Background: Platelets and coagulation proteins contribute to the development of peripheral arterial disease, especially atherosclerotic disease. Several experimental studies have proven a significant correlation between hypercoagulability and atherosclerosis. We used dielectric blood coagulometry, which was initially designed to evaluate the coagulable status, to examine the coagulability of peripheral arterial disease patients, and investigated the factors that were significantly correlated with the results. Read More

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http://dx.doi.org/10.1186/s12907-017-0054-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569553PMC
August 2017
7 Reads

Malignant Deciduoid Mesothelioma: case presentation of an exceptional variant and review of the literature.

BMC Clin Pathol 2017 18;17:13. Epub 2017 Aug 18.

Department of Pathology, National Institute of Oncology, Rabat, Morocco.

Background: Malignant Deciduoid Mesothelioma (MDM) is an extremely rare variant of epithelioid mesothelioma. It was first described in young females, in the peritoneum, and its relation with asbestos was not well defined. Later reports, have shown that this variant may also occur in the pleura, the pericardium and the tunica vaginalis of elderly people, who had been exposed to asbestos. Read More

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http://dx.doi.org/10.1186/s12907-017-0051-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562973PMC
August 2017
19 Reads

Inflammatory myofibroblastic tumor of the lacrimal gland: case report of an exceptional location.

BMC Clin Pathol 2017 17;17:12. Epub 2017 Aug 17.

Department of Pathology, Military General Hospital Mohammed V, Mohammed V- Souissi University, Hay Riad, Postal code 10000 Rabat, Morocco.

Background: Inflammatory myofibroblastic tumour (IMT) is a mesenchymal neoplasm of intermediate biological potential that may affect a wide range of anatomic sites but has a particular predilection for the lung and intra-abdominal soft tissues.

Case Presentation: We report here an exceptional case of inflammatory myofibroblastic tumor arising in the lacrimal gland and presenting as an orbital mass in a 24-year-old male.

Conclusion: This report aims to discuss the importance of histopathological and immunohistochemical findings in arriving at the diagnosis, which helps dictate the management, treatment and prognosis of the patient. Read More

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http://dx.doi.org/10.1186/s12907-017-0050-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561625PMC
August 2017
42 Reads

Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X.

BMC Clin Pathol 2017 17;17:11. Epub 2017 Aug 17.

Department of Pathology, Copenhagen University Hospital, Hvidovre, Denmark.

Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Read More

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http://dx.doi.org/10.1186/s12907-017-0052-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559789PMC
August 2017
10 Reads

Traceability and distribution of DNA in archived post mortem tissue samples from patients with systemic meningococcal disease.

BMC Clin Pathol 2017 16;17:10. Epub 2017 Aug 16.

Blood Cell Research Group, Section for Research, Department of Medical Biochemistry, Oslo University Hospital HF, Ullevål Hospital, PO Box 4956 Nydalen, 0424 Oslo, Norway.

Background: The pathophysiology and outcome of meningococcal septic shock is closely associated with the plasma level of lipopolysaccharides (LPS, endotoxin) and the circulating level of meningococcal DNA. The aim of the present study was to quantify the number of in different formalin-fixed, paraffin-embedded (FFPE) tissue samples and fresh frozen (FF) tissue samples from patients with systemic meningococcal disease (SMD), to explore the distribution of in the body.

Methods: DNA in FFPE and FF tissue samples from heart, lungs, liver, kidneys, spleen and brain from patients with meningococcal shock and controls (lethal pneumococcal infection) stored at variable times, were isolated. Read More

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http://dx.doi.org/10.1186/s12907-017-0049-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559868PMC
August 2017
16 Reads

Nucleic acid extraction from formalin-fixed paraffin-embedded cancer cell line samples: a trade off between quantity and quality?

BMC Clin Pathol 2016 14;16:17. Epub 2016 Nov 14.

AstraZeneca Oncology Innovative Medicines, Alderley Park, Macclesfield, UK.

Background: Advanced genomic techniques such as Next-Generation-Sequencing (NGS) and gene expression profiling, including NanoString, are vital for the development of personalised medicines, as they enable molecular disease classification. This has become increasingly important in the treatment of cancer, aiding patient selection. However, it requires efficient nucleic acid extraction often from formalin-fixed paraffin-embedded tissue (FFPE). Read More

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http://dx.doi.org/10.1186/s12907-016-0039-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477763PMC
November 2016
29 Reads

A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter.

BMC Clin Pathol 2017 2;17. Epub 2017 Jun 2.

Department of Pathology, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka City, Osaka, 543-0035 Japan.

Background: Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo The case of a PDTC adjacent to a pre-existing nodular goiter is very rare.

Case Presentation: A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papillary thyroid carcinoma. Carcinoma cells were arranged in trabecular, solid, and microfollicular histological patterns and displayed high mitotic activity. Read More

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http://dx.doi.org/10.1186/s12907-017-0048-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457633PMC
June 2017
11 Reads

High expression of EphA3 (erythropoietin-producing hepatocellular A3) in gastric cancer is associated with metastasis and poor survival.

BMC Clin Pathol 2017 27;17. Epub 2017 Apr 27.

Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

Background: As the major subfamily of receptor tyrosine, erythropoietin-producing hepatocellular (Eph) receptor has been related to progression and prognosis in different types of tumors. However, the role and mechanism of EPHA3 in gastric cancer is still not well understood.

Methods: Specimen were collected from 202 patients who underwent gastric resection for gastric adenocarcinoma. Read More

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http://dx.doi.org/10.1186/s12907-017-0047-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408411PMC
April 2017
7 Reads

Utilizing BD MAX™ Enteric Bacterial Panel to Detect Stool Pathogens from Rectal Swabs.

BMC Clin Pathol 2017 8;17. Epub 2017 Apr 8.

Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 USA.

Background: The BD MAX™ Enteric Bacterial Panel (BDM-EBP) is designed and FDA-cleared to detect and Shiga toxin genes from stool samples. However, rectal swabs, which are not FDA-cleared for clinical testing with the BDM-EBP, are common specimens received from pediatric patients for enteric pathogen testing. The purpose of this study was to evaluate the ability of the BDM-EBP to detect stool pathogens from rectal swabs. Read More

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http://dx.doi.org/10.1186/s12907-017-0043-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385029PMC
April 2017
15 Reads

Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis.

BMC Clin Pathol 2017 8;17. Epub 2017 Apr 8.

Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway.

Background: The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occurred in a founding cell and spread through cell division. Read More

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http://bmcclinpathol.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12907-017-0042-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385042PMC
April 2017
24 Reads

Bone pathologic fracture revealing an unusual association: coexistence of Langerhans cell histiocytosis with Rosai-Dorfman disease.

BMC Clin Pathol 2017 7;17. Epub 2017 Apr 7.

Departement of pathology, Hassan II University hospital, Fès, Morocco.

Background: The coexistence of Rosai-Dorfman disease (RDD) with Langerhans cell histiocytosis (LCH) is very rare, as to date only 17 cases have been reported in the english literature. The pathophysiology of this uncommon co-occurrence still remains enigmatic and a subject of various speculations.

Case Presentation: We report a case of a 30-year-old female patient who presented with a pathologic fracture of the left proximal femur. Read More

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http://dx.doi.org/10.1186/s12907-017-0044-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383940PMC
April 2017
24 Reads

Can takotsubo cardiomyopathy be diagnosed by autopsy? Report of a presumed case presenting as cardiac rupture.

BMC Clin Pathol 2017 5;17. Epub 2017 Apr 5.

Departments of Medicine, Maisonneuve-Rosemont Hospital, 5415 Boulevard de L'Assomption, Montreal, Quebec H1T 2M4 Canada.

Background: Takostsubo (stress) cardiomyopathy (TC) is a clinical syndrome featuring transient left ventricular dysfunction and wall-motion abnormalities, usually following emotional or physical stress. The diagnosis of TC depends on fulfillment of multiple clinical criteria. Although the pathogenesis has not been firmly established, myocardial cathecholamine toxicity is thought to represent a primary mechanism. Read More

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http://dx.doi.org/10.1186/s12907-017-0045-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382367PMC
April 2017
8 Reads

Expression of human epidermal growth factor receptor 2 in bladder urothelial carcinoma.

BMC Clin Pathol 2017 4;17. Epub 2017 Apr 4.

Department of Pathology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.

Background: Urothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. Despite many reports in the literature, the prognostic significance of this overexpression remains unclear. Read More

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http://dx.doi.org/10.1186/s12907-017-0046-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381084PMC
April 2017
10 Reads

Peritumoral lymphatic vessel density and invasion detected with immunohistochemical marker D240 is strongly associated with distant metastasis in breast carcinoma.

BMC Clin Pathol 2017 10;17. Epub 2017 Feb 10.

School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Background: Detection of vascular invasion by hematoxylin and eosin staining is the current pathological assessment practice to diagnose breast carcinoma. However, conventional hematoxylin and eosin staining failed to distinguish between blood vessel invasion and lymphatic vessel invasion. Both are important prognostic criteria however with different outcomes. Read More

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http://bmcclinpathol.biomedcentral.com/articles/10.1186/s129
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http://dx.doi.org/10.1186/s12907-017-0041-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301373PMC
February 2017
19 Reads

Mycetoma in a non-endemic area: a diagnostic challenge.

BMC Clin Pathol 2017 2;17. Epub 2017 Feb 2.

Departement of Pathology, Hassan II Teaching Hospital, Fès, Morocco.

Background: Mycetoma is a chronic granulomatous infectious disease caused by filamentous bacteria or by fungi. The disease is endemic in certain tropical and subtropical areas of the world but can be found elsewhere posing sometimes a diagnostic challenge for clinicians.

Case Presentation: A 65-year- old man presented with a right foot swelling evolving for 25 years. Read More

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http://dx.doi.org/10.1186/s12907-017-0040-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288886PMC
February 2017
31 Reads

Chromosomal abnormality of acute promyelocytic leukemia other than -: a case report of acute promyelocytic leukemia with del(5q).

BMC Clin Pathol 2016 4;16:16. Epub 2016 Oct 4.

Division of Hematology and Stem Cell Transplantation, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793 Japan.

Background: The recent study described a better outcome in acute promyelocytic leukemia patients treated with all-trans retinoic acid and arsenic oxide compared to those treated with all-trans retinoic acid combined with conventional chemotherapy. The pivotal study indicated that favorable-risk acute promyelocytic leukemia patients can be cured without any cytotoxic chemotherapy. Even high-risk patients are treatable with cytotoxic agents. Read More

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http://bmcclinpathol.biomedcentral.com/articles/10.1186/s129
Publisher Site
http://dx.doi.org/10.1186/s12907-016-0038-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050668PMC
October 2016
27 Reads