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    1546 results match your criteria BMC Cardiovascular Disorders[Journal]

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    Financial burden of survivors of medically-managed myocardial infarction and its association with selected social determinants and quality of life in a lower middle income country.
    BMC Cardiovasc Disord 2017 Sep 19;17(1):251. Epub 2017 Sep 19.
    Cardiology Unit, National Hospital Sri Lanka, Colombo, Sri Lanka.
    Background: Burden from ischemic heart disease is rising in Sri Lanka due to the demographic and epidemiological transitions. Documented literature is scarce on quality of life, financial burden and its determinants in relation to myocardial infarction (MI). This study was done to describe the financial burden among the survivors of MI managed only with drugs (i. Read More

    The association of sleep disordered breathing with left ventricular remodeling in CAD patients: a cross-sectional study.
    BMC Cardiovasc Disord 2017 Sep 18;17(1):250. Epub 2017 Sep 18.
    Behavioral Medicine Institute, Lithuanian University of Health Sciences, Vyduno 4, 00135, Palanga, Lithuania.
    Background: There is still insufficient knowledge on the potential effect of mild to moderate sleep-disordered breathing (SDB) that is widely prevalent, often asymptomatic, and largely undiagnosed in patients with stable coronary artery disease (CAD). SDB affects 34% of men and 17% of women aged between 30 and 70. The objective of this study was to evaluate the association between SDB and left ventricular (LV) hypertrophy as well as structural remodeling in stable CAD patients. Read More

    Medical therapy following hospitalization for heart failure with reduced ejection fraction and association with discharge to long-term care: a cross-sectional analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) population.
    BMC Cardiovasc Disord 2017 Sep 16;17(1):249. Epub 2017 Sep 16.
    Weill Cornell Medicine, New York, NY, USA.
    Background: Less intensive treatment for heart failure with reduced ejection fraction (HFrEF) may be appropriate for patients in long-term care settings because of limited life expectancy, frailty, comorbidities, and emphasis on quality of life.

    Methods: We compared treatment patterns between REasons for Geographic And Racial Differences in Stroke (REGARDS) study participants discharged to long-term care versus home following HFrEF hospitalizations. We examined medical records and Medicare pharmacy claims for 147 HFrEF hospitalizations among 80 participants to obtain information about discharge disposition and medication prescriptions and fills. Read More

    Anemia in severe heart failure patients: does it predict prognosis?
    BMC Cardiovasc Disord 2017 Sep 16;17(1):248. Epub 2017 Sep 16.
    Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Background: Anemia is highly prevalent in heart failure (HF) patients. However, the prevalence, clinical impact and prognostic factor of anemia in heart failure patients is widely varies. The aim of this study was to evaluate the prevalence of anemia in patients with HF, to compare baseline clinical characteristic and outcomes of severe HF patients with and without anemia admitted to Gondar University Referral Hospital (GURH), Gondar, Ethiopia. Read More

    Nutrition in primary and secondary prevention of cardiovascular risk in the continental and Mediterranean regions of Croatia.
    BMC Cardiovasc Disord 2017 Sep 16;17(1):247. Epub 2017 Sep 16.
    Division of Cardiology, Department of Internal Medicine, Sveti Duh University Hospital, Zagreb, Croatia.
    Background: The aim of this observational study was to evaluate the effect of Mediterranean and continental nutrition on cardiovascular risk in patients with acute and chronic coronary heart disease in Croatia.

    Methods: The study included 1284 patients who were hospitalized in a 28-month period due to acute or chronic ischaemic heart disease in hospitals across Croatia. An individual questionnaire was prepared which enabled recording of various cardiovascular risk factors. Read More

    Resting heart rate and impaired glucose regulation in middle-aged and elderly Chinese people: a cross-sectional analysis.
    BMC Cardiovasc Disord 2017 Sep 13;17(1):246. Epub 2017 Sep 13.
    Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
    Background: Elevated resting heart rate (RHR) has been reported to be associated with metabolic syndrome and type 2 diabetes. The aim of this study was to explore whether a positive relationship exists between RHR and impaired glucose regulation (IGR) among middle-aged and older Chinese individuals.

    Methods: We conducted a cross-sectional analysis that included a total of 9898 subjects (3194 men and 6704 women) in a Chinese population. Read More

    Determination of risk factors affecting the in-hospital prognosis of patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention.
    BMC Cardiovasc Disord 2017 Sep 12;17(1):243. Epub 2017 Sep 12.
    School of Nursing, Guangdong Pharmaceutical University, Guangzhou, 510310, China.
    Background: To determine the factors affecting the in-hospital prognosis of patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI), and to establish its prognostic discriminant model.

    Methods: A total of 701 consecutive STEMI patients undergoing PCI were enrolled in this study. The patients were divided into two groups, good prognosis and poor prognosis, based on whether the patient had adverse outcomes (death or heart function ≥ grade III) at discharge. Read More

    Barriers to lifestyle changes for prevention of cardiovascular disease - a survey among 40-60-year old Danes.
    BMC Cardiovasc Disord 2017 Sep 12;17(1):245. Epub 2017 Sep 12.
    Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, J.B.Winsløwvej 9, DK-5000, Odense, Denmark.
    Background: Elimination of modifiable risk factors including unhealthy lifestyle has the potential for prevention of 80% of cardiovascular disease cases. The present study focuses on disclosing barriers for maintaining specific lifestyle changes by exploring associations between perceiving these barriers and various sociodemographic and health-related characteristics.

    Methods: Data were collected through a web-based questionnaire survey and included 962 respondents who initially accepted treatment for a hypothetical cardiovascular risk, and who subsequently stated that they preferred lifestyle changes to medication. Read More

    One symptom, two arrhythmias: the rare and the even rarer.
    BMC Cardiovasc Disord 2017 Sep 12;17(1):244. Epub 2017 Sep 12.
    Department of Cardiology & Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625, Hannover, Germany.
    Background: Wolff-Parkinson-White (WPW) syndrome and idiopathic left ventricular tachycardia (ILVT) are rare and up to now the coexistence of both entities has rarely been reported. In patients with ventricular preexcitation the underlying mechanism of paroxysmal tachycardia most likely is atrioventricular reentrant tachycardia (AVRT). However, without ECG documentation of the tachycardia diagnosis of the underlying mechanism cannot be made due to similar clinical presentation of AVRT and ILVT. Read More

    Chronic kidney disease and diabetes associated with long-term outcomes in patients receiving percutaneous coronary intervention.
    BMC Cardiovasc Disord 2017 Sep 11;17(1):242. Epub 2017 Sep 11.
    Division of Pediatric General Medicine, Department of Pediatrics, Chang Gung Memorial Hospital at Linko, No. 5, Fu-Hsin Street, Kweishan, Taoyuan, Taiwan.
    Background: The effect of diabetes mellitus (DM) and chronic kidney disease (CKD) on long-term outcomes in patients receiving percutaneous coronary intervention (PCI) is unclear.

    Methods: A total of 1394 patients who underwent PCI were prospectively enrolled and divided into 4 groups according to the presence or absence of DM or CKD. Baseline characteristics, risk factors, medications, and angiographic findings were compared. Read More

    Medical and sociodemographic factors predict persistent smoking after coronary events.
    BMC Cardiovasc Disord 2017 Sep 6;17(1):241. Epub 2017 Sep 6.
    Department of Medicine, Drammen Hospital, PB 800, 3004, Drammen, Norway.
    Background: Understanding the determinants of persistent smoking after a coronary event constitutes the basis of modelling interventions of smoking cessation in secondary prevention programs. We aim to identify the potentially modifiable medical, sociodemographic and psychosocial factors, comprising the study factors, associated with unfavourable risk factor control after CHD events.

    Methods: A cross-sectional explorative study used logistic regression analysis to investigate the association between study factors and smoking status in 1083 patients hospitalized with myocardial infarction and/or coronary revascularization. Read More

    Long-term outcomes of coronary artery bypass grafting versus stent-PCI for unprotected left main disease: a meta-analysis.
    BMC Cardiovasc Disord 2017 Sep 6;17(1):240. Epub 2017 Sep 6.
    Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, 88100, Catanzaro, Italy.
    Background: Coronary artery bypass graft (CABG) surgery has traditionally represented the standard of care for left main coronary artery (LMCA) disease. However, percutaneous coronary intervention with stent implantation (PCI) has more recently emerged as a valuable alternative. The long-time awaited results of the largest randomized trials on the long-term impact of PCI versus CABG in LMCA disease, the newly published NOBLE and EXCEL studies, revealed contrasting results. Read More

    Sildenafil dosed concomitantly with bosentan for adult pulmonary arterial hypertension in a randomized controlled trial.
    BMC Cardiovasc Disord 2017 Sep 6;17(1):239. Epub 2017 Sep 6.
    Pfizer Inc, 4 E Carol Ave, Burlingame, New York, CA, 94010, USA.
    Background: Few controlled clinical trials exist to support oral combination therapy in pulmonary arterial hypertension (PAH).

    Methods: Patients with PAH (idiopathic [IPAH] or associated with connective tissue disease [APAH-CTD]) taking bosentan (62.5 or 125 mg twice daily at a stable dose for ≥3 months) were randomized (1:1) to sildenafil (20 mg, 3 times daily; n = 50) or placebo (n = 53). Read More

    Comparative effectiveness of rivaroxaban versus warfarin or dabigatran for the treatment of patients with non-valvular atrial fibrillation.
    BMC Cardiovasc Disord 2017 Sep 6;17(1):238. Epub 2017 Sep 6.
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
    Background: Rivaroxaban is an oral anticoagulant approved in the US for prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF). We determined the effectiveness and associated risks of rivaroxaban versus other oral anticoagulants in a large real-world population.

    Methods: We selected NVAF patients initiating oral anticoagulant use in 2010-2014 enrolled in MarketScan databases. Read More

    Myocardial infarction during anaphylaxis in a young healthy male with normal coronary arteries- is epinephrine the culprit?
    BMC Cardiovasc Disord 2017 Sep 4;17(1):237. Epub 2017 Sep 4.
    National Hospital, Colombo, Sri Lanka.
    Background: Anaphylaxis is an acute, potentially fatal medical emergency. Myocardial injury or infarction in the setting of an anaphylaxis can be due the anaphylaxis itself, when it is known as Kounis syndrome or it can also be due to the effect of epinephrine treatment. Epinephrine is considered as the cornerstone in management of anaphylaxis. Read More

    Adherence and outcomes to direct oral anticoagulants among patients with atrial fibrillation: findings from the veterans health administration.
    BMC Cardiovasc Disord 2017 Sep 2;17(1):236. Epub 2017 Sep 2.
    Division of Cardiology - Campus Box B130, University of Colorado Anschutz Medical Campus, 12631 E. 17th Avenue, Aurora, CO, 80045, USA.
    Background: The direct oral anticoagulants (DOACs) reduce the risk of stroke in moderate to high-risk patients with non-valvular atrial fibrillation (AF). Yet, concerns remain regarding its routine use in real world practice. We sought to describe adherence patterns and the association between adherence and outcomes to the DOACs among outpatients with AF. Read More

    The top tertile of hematocrit change during hospitalization is associated with lower risk of mortality in acute heart failure patients.
    BMC Cardiovasc Disord 2017 Sep 2;17(1):235. Epub 2017 Sep 2.
    State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
    Background: Hemoconcentration has been proposed as surrogate for changes in volume status among patients hospitalized with acute heart failure (AHF) and is associated with a favorable outcome. However, there is a dearth of research assessing the clinical outcomes of hospitalized patients with hemoconcentration, hemodilution and unchanged volume status.

    Methods: We enrolled 510 consecutive patients hospitalized for AHF from April 2011 to July 2015. Read More

    Efficacy and safety of transcatheter aortic valve replacement in aortic stenosis patients at low to moderate surgical risk: a comprehensive meta-analysis.
    BMC Cardiovasc Disord 2017 Aug 24;17(1):234. Epub 2017 Aug 24.
    Faculty of Medicine, Damascus University, Damascus, Syria.
    Background: Recently, transcatheter aortic valve replacement (TAVR) has become the procedure of choice in high surgical risk patients with aortic stenosis (AS). However, its value is still debated in operable AS cases. We performed this meta-analysis to compare the safety and efficacy of TAVR to surgical aortic valve replacement (SAVR) in low-to-moderate surgical risk patients with AS. Read More

    PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights.
    BMC Cardiovasc Disord 2017 Aug 24;17(1):233. Epub 2017 Aug 24.
    Division of Cardiology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Rm 1928, Block K, Hong Kong, China.
    Background: Whether PR prolongation independently predicts new-onset ischemic events of myocardial infarction and stroke was unclear. Underlying pathophysiological mechanisms of PR prolongation leading to adverse cardiovascular events were poorly understood. We investigated the role of PR prolongation in pathophysiologically-related adverse cardiovascular events and underlying mechanisms. Read More

    2-Dimensional Speckle Tracking Echocardiography predicts severe coronary artery disease in women with normal left ventricular function: a case-control study.
    BMC Cardiovasc Disord 2017 Aug 24;17(1):231. Epub 2017 Aug 24.
    Department of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
    Background: Women who have coronary artery disease (CAD) often present with atypical symptoms that may lead to misdiagnosis. We assessed strain, systolic strain rate and left ventricular dyssynchrony with 2- dimensional- speckle tracking echocardiography to evaluate its use as a non-invasive method for detecting CAD in women with normal ejection fraction compared with healthy women controls with a normal angiogram.

    Methods: We included 35 women with CAD confirmed by coronary angiography and a positive exercise stress echocardiography and 35 women in a control group with a low pretest probability of CAD, normal angiogram and a normal stress echocardiography with normal EF. Read More

    Persistence with antihypertensives in uncomplicated treatment-naïve very elderly patients: a nationwide population-based study.
    BMC Cardiovasc Disord 2017 Aug 24;17(1):232. Epub 2017 Aug 24.
    College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 15588, South Korea.
    Background: Limited studies have evaluated the medication-taking behavior in very elderly hypertensive patients. The aim of this study was to evaluate the persistence and adherence with antihypertensive agents in treatment-naïve patients, along with other related factors, according to age.

    Methods: Adult (19-64 years), elderly (65-79 years), and very elderly (≥80 years) uncomplicated hypertensive patients starting antihypertensive monotherapy were identified from the National Health Insurance claims database. Read More

    Does dapagliflozin regress left ventricular hypertrophy in patients with type 2 diabetes? A prospective, double-blind, randomised, placebo-controlled study.
    BMC Cardiovasc Disord 2017 Aug 23;17(1):229. Epub 2017 Aug 23.
    Cardiovascular Medicine and Therapeutics, Division of Molecular and Clinical Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Mailbox 2, Dundee, DD1 9SY, UK.
    Background: Patients with diabetes have a two to fourfold increased risk for development of and death from cardiovascular disease [CVD]. The current oral hypoglycaemic agents result in limited reduction in this cardiovascular risk. Sodium glucose linked co-transporter type 2 [SGLT2] inhibitors are a relatively new class of antidiabetic agent that have been shown to have potential cardiovascular benefits. Read More

    Better Indigenous Risk stratification for Cardiac Health study (BIRCH) protocol: rationale and design of a cross-sectional and prospective cohort study to identify novel cardiovascular risk indicators in Aboriginal Australian and Torres Strait Islander adults.
    BMC Cardiovasc Disord 2017 Aug 23;17(1):228. Epub 2017 Aug 23.
    Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia.
    Background: Of the estimated 10-11 year life expectancy gap between Indigenous (Aboriginal and Torres Strait Islander people) and non-Indigenous Australians, approximately one quarter is attributable to cardiovascular disease (CVD). Risk prediction of CVD is imperfect, but particularly limited for Indigenous Australians. The BIRCH (Better Indigenous Risk stratification for Cardiac Health) project aims to identify and assess existing and novel markers of early disease and risk in Indigenous Australians to optimise health outcomes in this disadvantaged population. Read More

    Prehypertension and psychosocial risk factors among university students in ASEAN countries.
    BMC Cardiovasc Disord 2017 Aug 23;17(1):230. Epub 2017 Aug 23.
    Faculty of Public Health, Mahasarakham University, Maha Sarakham, Thailand.
    Background: Existing evidence suggests that the cardiovascular morbidities are increasing among pre-hypertensive individuals compared to normal. The aim of this study was to evaluate the prevalence of prehypertension, hypertension and to identify psychosocial risk factors for prehypertension among university students in Association of South East Asian Nation (ASEAN) countries.

    Methods: Based on a cross-sectional survey, the total sample included 4649 undergraduate university students (females = 65. Read More

    miR-941 as a promising biomarker for acute coronary syndrome.
    BMC Cardiovasc Disord 2017 Aug 22;17(1):227. Epub 2017 Aug 22.
    Xiyuan Hospital, China Academy of Chinese Medical Sciences, 1 Xiyuan Caochang, Haidian district, Beijing, China.
    Background: Circulating miRNAs can function as biomarkers for diagnosis, treatment, and prevention of diseases. However, it is unclear whether miRNAs can be used as biomarkers for acute coronary syndrome (ACS). To this end, we applied gene chip technology to analyze miRNA expression in patients with stable angina (SA), non-ST elevation ACS (NSTE-ACS), and ST-segment elevation myocardial infarction (STEMI). Read More

    Patients with symptoms and characteristics consistent with obstructive sleep apnea are at a higher risk for acute and subacute stent thrombosis after percutaneous coronary stent implantation: a single-center case-control study.
    BMC Cardiovasc Disord 2017 Aug 18;17(1):226. Epub 2017 Aug 18.
    Department of Cardiology, Chinese PLA General Hospital, Beijing, 1000853, China.
    Background: To determine if obstructive sleep apnea (OSA) is a risk factor for early stent thrombosis (EST; within 30 days) after percutaneous coronary intervention (PCI).

    Methods: This case-control study involved 23 patients with angiographically confirmed EST after PCI (case group) and 92 PCI patients (control group) who did not develop stent thrombosis during a 2-year follow-up. Patients with symptoms and characteristics consistent with OSA (hereinafter referred to as OSA) were identified using the Berlin questionnaire, and the general characteristics of the patients and their treatments as well as outcomes were recorded. Read More

    Evaluation of therapy management and outcome in Takotsubo syndrome.
    BMC Cardiovasc Disord 2017 Aug 17;17(1):225. Epub 2017 Aug 17.
    Department of Cardiology, HELIOS Medical Center Wuppertal, University Hospital Witten/Herdecke, Arrenberger Str. 20, 42117, Wuppertal, Germany.
    Background: To date there is no validated evidence for standardized treatment of patients with Takotsubo syndrome (TTS). Medication therapy after final TTS diagnosis remains unclear. Previous data on patient outcome is ambivalent. Read More

    Predicted impact of lipid lowering therapy on cardiovascular and economic outcomes of Swedish atherosclerotic cardiovascular disease guideline.
    BMC Cardiovasc Disord 2017 Aug 16;17(1):224. Epub 2017 Aug 16.
    Amgen (Europe) GmbH, Zug, Switzerland.
    Background: The effects on cardiovascular disease (CVD) by treatment recommendations on prevention of atherosclerotic CVD remain to be evaluated. The objectives were to assess treatment gap for low density lipoprotein cholesterol (LDL-C) according to guidelines, potential impact on CVD outcomes, and possible avoided economic costs, in post myocardial infarction (MI) patients, if target LDL-C levels of ≤1.8 mmol/L would be achieved. Read More

    Left ventricular contractile reserve by stress echocardiography as a predictor of response to cardiac resynchronization therapy in heart failure: a systematic review and meta-analysis.
    BMC Cardiovasc Disord 2017 Aug 16;17(1):223. Epub 2017 Aug 16.
    CNR, Institute of Clinical Physiology, Pisa, Italy.
    Background: The presence of left ventricular contractile reserve (LVCR) during stress echo (SE) may provide favorable response to cardiac resynchronization therapy (CRT) in heart failure patients. The aim of the study was to perform a meta-analysis of available SE data in this set of patients.

    Methods: From a Pubmed and Advance Google Scholar database web based search scan up to December 2016, we initially identified 5906 records. Read More

    Polymer-free dual drug-eluting stents evaluated in a porcine model.
    BMC Cardiovasc Disord 2017 Aug 15;17(1):222. Epub 2017 Aug 15.
    Department of Cardiology, Peking University First Hospital, No. 8 Xishiku Str., Xicheng District, Beijing, 100034, China.
    Background: Although drug-eluting stents have dramatically reduced the rates of restenosis and target lesion revascularization, they are associated with stent thrombosis (ST), a catastrophic event likely due to delayed endothelialization and chronic inflammation caused by the polymer and the metal scaffolds. To increase the safety and efficacy of stents, polymer-free dual drug-eluting stents (DDES) have been developed.

    Methods: A total 160 stents (Bare-metal stents (BMS), polymer-free probucol stents (PrES), sirolimus-eluting stents (SES) and DDES) were randomly implanted in the coronary arteries of 80 pigs. Read More

    Integrative and quantitive evaluation of the efficacy of his bundle related pacing in comparison with conventional right ventricular pacing: a meta-analysis.
    BMC Cardiovasc Disord 2017 Aug 11;17(1):221. Epub 2017 Aug 11.
    Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
    Background: Long-term RVP could bring adverse problems to cardiac electro-mechanics and result in inter- and intra-ventricular asynchrony, impaired labor force, and aggravation of cardiac function. HBRP including direct His bundle pacing and para-His bundle pacing was regarded as a novel physiological pacing pattern to avoid devastating cardiac function. This synthetic study was conducted to integratively and quantitatively evaluate the efficacy of His bundle related pacing (HBRP) in comparison with conventional right ventricular pacing (RVP). Read More

    In-vitro examination of the positive inotropic effect of caffeine and taurine, the two most frequent active ingredients of energy drinks.
    BMC Cardiovasc Disord 2017 Aug 10;17(1):220. Epub 2017 Aug 10.
    Department of Cardiothoracic and Vascular Surgery, University Hospital of Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
    Background: Our study aimed to evaluate changes in the contractile behavior of human myocardium after exposure to caffeine and taurine, the main active ingredients of energy drinks (EDs), and to evaluate whether taurine exhibits any inotropic effect at all in the dosages commonly used in EDs.

    Methods: Myocardial tissue was removed from the right atrial appendages of patients undergoing cardiac surgery and prepared to obtain specimens measuring 4 mm in length. A total of 92 specimens were exposed to electrical impulses at a frequency of 75 bpm for at least 40 min to elicit their maximum contractile force before measuring the isometric contractile force (ICF) and duration of contraction (CD). Read More

    Left ventricular longitudinal function assessment in rabbits after acute occlusion of left anterior descending coronary artery by two-dimensional speckle tracking imaging.
    BMC Cardiovasc Disord 2017 Aug 8;17(1):219. Epub 2017 Aug 8.
    Department of Echocardiography, ChangZhou No.2 People's Hospital Affiliated to NanJing Medical University, ChangZhou, 213003, China.
    Abstact: BACKGROUND: To evaluate the left ventricular (LV) longitudinal function changes in rabbits after acute occlusion of the left anterior descending artery (LAD) by two-dimensional speckle tracking imaging (2D-STI).

    Methods: Forty-eight New Zealand white rabbits underwent echocardiography examination. EchoPAC was used to measure LV peak systolic longitudinal strain (LS) of the endocardium, middle myocardium, and epicardium, peak longitudinal strain rate (LSr), segmental and global longitudinal rotation (LR) degrees. Read More

    Models for improved diagnosis of left ventricular hypertrophy based on conventional electrocardiographic criteria.
    BMC Cardiovasc Disord 2017 Aug 8;17(1):217. Epub 2017 Aug 8.
    Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
    Background: Electrocardiogram (ECG) is commonly used clinically due to convenience, but its accuracy is insufficient for left ventricular hypertrophy (LVH) diagnosis. In this study, we attempted to improve diagnostic accuracy of LVH by establishing models with ECG parameters.

    Methods: Eighty hundred and twenty eight patients were recruited in the present study which were divided into groups according to gender, age and body mass index (BMI). Read More

    Risk factors of metabolic syndrome among hypertensive patients at Hawassa University Comprehensive Specialized Hospital, Southern Ethiopia.
    BMC Cardiovasc Disord 2017 Aug 8;17(1):218. Epub 2017 Aug 8.
    University of Gondar, College of Medicine and Health Science, School of Biomedical and Laboratory Sciences, Gondar, Ethiopia.
    Background: Data regarding the prevalence of metabolic syndrome (MetS) among hypertensive patients in Ethiopia is very scarce, and the nature and the burden of MetS among these patients has not been well investigated. Therefore, the aim of this study was to assess the pattern and risk factors of MetS in hypertensive patients.

    Methods: A cross-sectional study was conducted at Hawassa University comprehensive specialized hospital from September 2015 to June 2016. Read More

    Effect of increased left ventricle mass on ischemia assessment in electrocardiographic signals: rabbit isolated heart study.
    BMC Cardiovasc Disord 2017 Aug 4;17(1):216. Epub 2017 Aug 4.
    Department of Biochemistry, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic.
    Background: Detailed quantitative analysis of the effect of left ventricle (LV) hypertrophy on myocardial ischemia manifestation in ECG is still missing. The associations between both phenomena can be studied in animal models. In this study, rabbit isolated hearts with spontaneously increased LV mass were used to evaluate the effect of such LV alteration on ischemia detection criteria and performance. Read More

    Prognostic value of short-term follow-up BNP in hospitalized patients with heart failure.
    BMC Cardiovasc Disord 2017 Aug 3;17(1):215. Epub 2017 Aug 3.
    Department of Cardiology, Wonju College of Medicine, Yonsei University, 20 Ilsan-ro, Gangwon-do, 26426, Wonju, Republic of Korea.
    Background: B-type natriuretic peptide (BNP) has prognostic significance in heart failure (HF), and reductions in BNP may predict clinical improvement. However, there are limited data regarding the prognostic value of BNP during short-term follow-up. The aim of this study was to evaluate the relationship between short-term follow-up BNP and mortality after discharge in patients with HF. Read More

    Left ventricular systolic function changes in hypertrophic cardiomyopathy patients detected by the strain of different myocardium layers and longitudinal rotation.
    BMC Cardiovasc Disord 2017 Aug 2;17(1):214. Epub 2017 Aug 2.
    Department of Echocardiography, ChangZhou No.2 People's Hospital Affiliated to NanJing Medical University, ChangZhou, 213003, China.
    Background: Impairment of left ventricular (LV) longitudinal function has an important role in hypertrophic cardiomyopathy (HCM). This research investigated an association between the longitudinal strain of different myocardial layers, longitudinal rotation and the LV systolic function of HCM patients.

    Methods: The research was performed on 36 HCM patients and 36 healthy subjects. Read More

    The cost-utility of point-of-care troponin testing to diagnose acute coronary syndrome in primary care.
    BMC Cardiovasc Disord 2017 Aug 2;17(1):213. Epub 2017 Aug 2.
    Department of Health Technology and Services Research, MIRA institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, the Netherlands.
    Background: The added value of using a point-of-care (POC) troponin test in primary care to rule out acute coronary syndrome (ACS) is debated because test sensitivity is inadequate early after symptom onset. This study investigates the potential cost-utility of diagnosing ACS by a general practitioner (GP) when a POC troponin test is available versus GP assessment only.

    Methods: A patient-level simulation model was developed, representing a hypothetical cohort of the Dutch population (>35 years) consulting the GP with chest complaints. Read More

    Antithrombotic treatment during coronary angioplasty after failed thrombolysis: strategies and prognostic implications. Results of the RESPIRE registry.
    BMC Cardiovasc Disord 2017 Aug 1;17(1):212. Epub 2017 Aug 1.
    Servicio de Cardiología, H de Galdakao, Vizcaya, Spain.
    Background: Thrombolysis is still used when primary angioplasty is delayed for a long time, but 25%-30% of patients require rescue angioplasty (RA). There are no established recommendations for antithrombotic management in RA. This registry analyzes regimens for antithrombotic management. Read More

    Surface ECG interatrial block-guided treatment for stroke prevention: rationale for an attractive hypothesis.
    BMC Cardiovasc Disord 2017 Jul 31;17(1):211. Epub 2017 Jul 31.
    Queen's University, Kingston, ON, Canada.
    Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with stroke, cognitive impairment, and cardiovascular death. Some predisposing factors - as aging, diabetes, hypertension - induce and maintain electrophysiological and ultrastructural remodeling that usually includes fibrosis. Interatrial conduction disturbances play a crucial role in the initiation of atrial fibrosis and in its associated complications. Read More

    Longitudinal shortening remains the principal component of left ventricular pumping in patients with chronic myocardial infarction even when the absolute atrioventricular plane displacement is decreased.
    BMC Cardiovasc Disord 2017 Jul 28;17(1):208. Epub 2017 Jul 28.
    Department of Clinical Sciences Lund, Clinical Physiology, Lund University, Skane University Hospital, Lund, Sweden.
    Background: The majority (60%) of left ventricular (LV) stroke volume (SV) is generated by longitudinal shortening causing apical atrioventricular plane displacement (AVPD) in systole. The remaining SV is caused by radial inward motion of the epicardium both in the septal and the lateral wall. We aimed to determine if these longitudinal, septal and lateral contributions to LVSV are changed in patients with chronic myocardial infarction (MI). Read More

    Association of serum C1q/TNF-related protein-3 (CTRP-3) in patients with coronary artery disease.
    BMC Cardiovasc Disord 2017 Jul 28;17(1):210. Epub 2017 Jul 28.
    Department of Geriatrics, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China.
    Background: Recent studies have demonstrated that complement C1q tumor necrosis factor related proteins (CTRPs) have diverse biological influences on the cardiovascular system. CTRP 3 is a member of the CTRP superfamily, which may play a pivotal role in the pathogenesis of coronary artery disease (CAD). Here, we investigated whether serum levels of CTRP 3 are associated with the prevalence and the severity of CAD. Read More

    A novel targeted angiogenesis technique using VEGF conjugated magnetic nanoparticles and in-vitro endothelial barrier crossing.
    BMC Cardiovasc Disord 2017 Jul 28;17(1):209. Epub 2017 Jul 28.
    Pondicherry Institute of Medical Sciences, Pondicherry, 605014, India.
    Background: Vascular endothelial growth factor is well known for its angiogenesis potential. The study was performed to determine the possible pro-angiogenic role of magnetic nanoparticles coupled to VEGF in vitro and their capacity to cross an endothelial monolayer. This novel treatment technique for angiogenesis could be potentially useful for therapeutic purposes using magnetic nanoparticles. Read More

    Impact of hypertension with or without diabetes on left ventricular remodeling in rural Chinese population: a cross-sectional study.
    BMC Cardiovasc Disord 2017 Jul 27;17(1):206. Epub 2017 Jul 27.
    Department of Cardiology, the First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, People's Republic of China.
    Background: The aim of this study was to assess the impact of hypertension with or without diabetes on left ventricular (LV) remodeling in rural Chinese population.

    Methods: A total of 10,270 participants were classified into control group, hypertension without diabetes (HT) group, and hypertension with diabetes (HT + DM) group. We compared clinical characteristics and echocardiographic parameters, and used multivariable logistic regression analysis to assess the associations of interest. Read More

    An exploratory study on the efficacy and safety of a BCAA preparation used in combination with cardiac rehabilitation for patients with chronic heart failure.
    BMC Cardiovasc Disord 2017 Jul 27;17(1):205. Epub 2017 Jul 27.
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Background: Sarcopenia is generally complicated with patients with chronic heart failure (CHF) and its presence negatively affects the course of heart failure, however effective nutritional intervention had not been elucidated yet. The primary objective of this study is to explore whether the addition of a branched-chain amino acid (BCAA) preparation for cardiac rehabilitation (CR) of patients with CHF further improves cardiopulmonary functions, skeletal muscle functions, and metabolism in comparison with conventional CR.

    Methods: This is a randomized, parallel-group comparative study. Read More

    A comparison of the real world effectiveness of catheter ablation and drug therapy in atrial fibrillation patients in a Chinese setting.
    BMC Cardiovasc Disord 2017 Jul 27;17(1):204. Epub 2017 Jul 27.
    Beijing Anzhen Hospital, Capital Medical University, No 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.
    Background: Studies have demonstrated that catheter ablation of atrial fibrillation is associated with better rhythm control than drug therapy. The present study aimed to assess the clinical outcomes and health-related quality of life of ablation therapy in a real world setting.

    Methods: A prospective, non-randomized, single center study in a real-world clinical setting in China was conducted. Read More

    Are women with type 2 diabetes mellitus more susceptible to cardiovascular complications following coronary angioplasty?: a meta-analysis.
    BMC Cardiovasc Disord 2017 Jul 27;17(1):207. Epub 2017 Jul 27.
    Institute of Cardiovascular Diseases, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530027, People's Republic of China.
    Background: Scientific reports have shown Type 2 Diabetes Mellitus (T2DM) to be independently associated with adverse outcomes following Percutaneous Coronary Intervention (PCI). However, gender difference has also often been a controversial issue following PCI. Till date, very few meta-analyses have systematically compared the adverse cardiovascular outcomes in male versus female patients with T2DM following PCI. Read More

    Migraine and percutaneous patent foramen ovale closure: a systematic review and meta-analysis.
    BMC Cardiovasc Disord 2017 Jul 26;17(1):203. Epub 2017 Jul 26.
    Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi, 710061, China.
    Background: The association between patent foramen ovale (PFO) and migraine with aura (MA) is well established. However, the benefits of PFO closure are less certain in patients with migraine without aura (MwoA).

    Methods: We systematically searched Pubmed for pertinent clinical studies published from January 2000 to July 2015. Read More

    Acute coronary syndrome and acute kidney injury: role of inflammation in worsening renal function.
    BMC Cardiovasc Disord 2017 Jul 26;17(1):202. Epub 2017 Jul 26.
    Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, 14080, Mexico City, Mexico.
    Background: Acute Kidney Injury (AKI), a common complication of acute coronary syndromes (ACS), is associated with higher mortality and longer hospital stays. The role of cytokines and other mediators is unknown in AKI induced by an ACS (ACS-AKI), leading to several unanswered questions. The worsening of renal function is usually seen as a dichotomous phenomenon instead of a dynamic change, so evaluating changes of the renal function in time may provide valuable information in the ACS-AKI setting. Read More

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