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    1700 results match your criteria BMC Cardiovascular Disorders[Journal]

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    Correlation of increased corrected TIMI frame counts and the topographical extent of isolated coronary artery ectasia.
    BMC Cardiovasc Disord 2018 May 22;18(1):102. Epub 2018 May 22.
    Department of Cardiology, Peking Union Medical College & Chinese Academy of Medical Science, Peking Union Medical College Hospital, No.1 Shuai Fu Yuan, Beijing, 100730, China.
    Background: The precise relationship between increased thrombolysis in myocardial infarction (TIMI) frame counts and the topographical extent of isolated coronary artery ectasia (CAE) has not been fully explained. New parameters of linear dimension (LD) and the estimated ectatic area (EEA) together with the diameter and ectasia ratio may be associated with the corrected TIMI frame count (CTFC) in isolated CAE patients.

    Methods: The topographical parameters of ectatic coronary arteries and/or segments of 77 isolated CAE patients were consecutively studied. Read More

    Effects of the cardiac myosin activator Omecamtiv-mecarbil on severe chronic aortic regurgitation in Wistar rats.
    BMC Cardiovasc Disord 2018 May 21;18(1):99. Epub 2018 May 21.
    Department of Cardiology, Erasme Hospital, ULB, Brussels, Belgium.
    Background: Aortic regurgitation (AR) is a valvular disease that can lead to systolic heart failure. Treatment options besides cardiac surgery are limited and consequently severe AR is associated with higher mortality and morbidity when not operated. In this investigation, we examined the effects of a novel cardiac myosin activator, Omecamtiv-mecarbil (OM), in rats with chronic severe AR. Read More

    Preexcitation syndrome: experimental study on the electrocardiogram of antegradely conducting accessory pathway.
    BMC Cardiovasc Disord 2018 May 21;18(1):100. Epub 2018 May 21.
    Department of Respiration Medicine of the First Affiliated Hospital of Jinzhou Medical University, Renmin Street, Jinzhou, 121000, Liaoning Province, China.
    Background: Preexcitation syndrome is characterized by a dominant delta wave on the baseline electrocardiogram (ECG), resulting from the change in QRS initial vector by the accessory pathway (AP). This study is to explore the effect of ventricular preexcitation on the QRS initial, maximal and terminal vector in an experimental rabbit with preexcitation syndrome induced by programmed electrical stimulation.

    Methods: Rabbits (n = 10) were randomized for the experimental model of ventricular preexcitation. Read More

    Effect of the patient education - Learning and Coping strategies - in cardiac rehabilitation on return to work at one year: a randomised controlled trial show (LC-REHAB).
    BMC Cardiovasc Disord 2018 May 21;18(1):101. Epub 2018 May 21.
    Cardiovascular Research Unit, Department of Cardiology, Regional Hospital West Jutland, Herning, Denmark.
    Background: Personal resources are identified as important for the ability to return to work (RTW) for patients with ischaemic heart disease (IHD) or heart failure (HF) undergoing cardiac rehabilitation (CR). The patient education 'Learning and Coping' (LC) addresses personal resources through a pedagogical approach. This trial aimed to assess effect of adding LC strategies in CR compared to standard CR measured on RTW status at one-year follow-up after CR. Read More

    Physical activity intervention for elderly patients with reduced physical performance after acute coronary syndrome (HULK study): rationale and design of a randomized clinical trial.
    BMC Cardiovasc Disord 2018 May 21;18(1):98. Epub 2018 May 21.
    Center of Biomedical Studies applied to Sport, Public Health Department, Azienda USL di Ferrara, Ferrara, Italy.
    Background: Reduced physical performance and impaired mobility are common in elderly patients after acute coronary syndrome (ACS) and they represent independent risk factors for disability, morbidity, hospital readmission and mortality. Regular physical exercise represents a means for improving functional capacity. Nevertheless, its clinical benefit has been less investigated in elderly patients in the early phase after ACS. Read More

    Impact of VKORC1, CYP4F2 and NQO1 gene variants on warfarin dose requirement in Han Chinese patients with catheter ablation for atrial fibrillation.
    BMC Cardiovasc Disord 2018 May 18;18(1):96. Epub 2018 May 18.
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
    Background: The anticoagulation of atrial fibrillation catheter ablation during the perioperative stage does matter and should be treated with discretion. We aimed to assess impact of three important genes participating in vitamin K cycle (i.e. Read More

    Should statin guidelines consider patient preferences? Eliciting preferences of benefit and harm outcomes of statins for primary prevention of cardiovascular disease in the sub-Saharan African and European contexts.
    BMC Cardiovasc Disord 2018 May 18;18(1):97. Epub 2018 May 18.
    Department of Epidemiology, Biostatistics & Prevention Institute, University of Zurich, Hirschengraben 84, CH-8001, Zurich, Switzerland.
    Background: Patient preferences are key parameters to evaluate benefit-harm balance of statins for primary prevention but they are not readily available to guideline developers and decision makers. Our study aimed to elicit patient preferences for benefit and harm outcomes related to use of statins for primary cardiovascular disease prevention and to examine how the preferences differ across economically and socio-culturally different environments.

    Methods: We conducted preference-eliciting surveys using best-worst scaling designed with a balanced incomplete-block design (BIBD) on 13 statins-related outcomes on 220 people in Ethiopia and Switzerland. Read More

    Presentation and outcomes of indigenous Australians with peripheral artery disease.
    BMC Cardiovasc Disord 2018 May 16;18(1):94. Epub 2018 May 16.
    Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, 4811, Australia.
    Background: The risk factors for peripheral artery disease (PAD) are more common in Indigenous than non-Indigenous Australians, however the presentation and outcome of PAD in Indigenous Australians has not been previously investigated. The aim of this prospective cohort study was to compare the presenting characteristics and clinical outcome of Indigenous and non-Indigenous Australians with PAD.

    Methods: PAD patients were prospectively recruited and followed-up since 2003 from an outpatient vascular clinic in Townsville, Australia. Read More

    Comparison of outcomes in emergency department patients with suspected cardiac chest pain: two-centre prospective observational study in Southern China.
    BMC Cardiovasc Disord 2018 May 16;18(1):95. Epub 2018 May 16.
    Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Prince of Wales Hospital, Main Clinical Block and Trauma Centre, Shatin, N.T, Hong Kong, China.
    Background: Hong Kong (HK) and Guangzhou (GZ) are cities in China with different healthcare systems. This study aimed to compare 30-day and 6-month mortality and characteristics of patients with suspected cardiac chest pain admitted to two emergency departments (ED) in HK and GZ.

    Methods: A prospective observational study enrolled patients with suspected cardiac chest pain presenting to EDs in the Prince of Wales Hospital (PWH), HK and the Second Affiliated Hospital of Guangzhou Medical University (AHGZMU),GZ. Read More

    Systolic characteristics and dynamic changes of the mitral valve in different grades of ischemic mitral regurgitation - insights from 3D transesophageal echocardiography.
    BMC Cardiovasc Disord 2018 May 10;18(1):93. Epub 2018 May 10.
    Yale School of Medicine, Section Cardiovascular Medicine, 330 Cedar Street, P.O Box 208017, New Haven, CT, 06511, USA.
    Background: Mitral regurgitation in ischemic heart disease (IMR) is a strong predictor of outcome but until now, pathophysiology is not sufficiently understood and treatment is not satisfying. We aimed to systematically evaluate structural and functional mitral valve leaflet and annular characteristics in patients with IMR to determine the differences in geometric and dynamic changes of the MV between significant and mild IMR.

    Methods: Thirty-seven patients with IMR (18 mild (m)MR, 19 significant (moderate+severe) (s)MR) and 33 controls underwent TEE. Read More

    Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study.
    BMC Cardiovasc Disord 2018 May 10;18(1):91. Epub 2018 May 10.
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Edgbaston, Birmingham, Birmingham, B15 2TT, UK.
    Background: The inter-relationships of atrial fibrillation (AF) to retinal vascular occlusions (whether retinal artery occlusion (RAO) or retinal venous occlusion (RVO)) remain unclear. It is unknown if a presentation of retinal artery or venous occlusions may indicate a new onset cardiac arrhythmia. To shed light on this association, we investigated the risk of new onset AF in patients with known RAO and RVO. Read More

    Three-years outcomes of diabetic patients treated with coronary bioresorbable scaffolds.
    BMC Cardiovasc Disord 2018 May 10;18(1):92. Epub 2018 May 10.
    Kardiologie I, Zentrum für Kardiologie, German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main, University Hospital Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.
    Background: Diabetes is among the strongest predictors of outcome after coronary artery stenting and the incidence of negative outcomes is still high in this specific group. Data of long-term outcomes comparing diabetic patients with non-diabetic patients treated with bioresorbable scaffolds are still incomplete. This work evaluates the long-term outcomes after implantation of a coronary bioresorbable scaffold (BRS) in diabetic patients compared to non-diabetics. Read More

    Renal denervation improves cardiac function by attenuating myocardiocyte apoptosis in dogs after myocardial infarction.
    BMC Cardiovasc Disord 2018 May 8;18(1):86. Epub 2018 May 8.
    Department of Cardiology, Tianjin First Center Hospital, Tianjin, China.
    Background: Myocardial apoptosis is important in the pathogenesis and progression of myocardial infarction-induced heart failure (MI-HF). Renal sympathetic denervation (RDN) has become a promising therapeutic strategy for the treatment of HF. Previous studies have shown that RDN could improve heart function Yao et al. Read More

    A novel ultrafast-low-dose computed tomography protocol allows concomitant coronary artery evaluation and lung cancer screening.
    BMC Cardiovasc Disord 2018 May 8;18(1):90. Epub 2018 May 8.
    Villa Mafalda Clinical Institute, Rome, Italy.
    Background: Cardiac computed tomography (CT) is often performed in patients who are at high risk for lung cancer in whom screening is currently recommended. We tested diagnostic ability and radiation exposure of a novel ultra-low-dose CT protocol that allows concomitant coronary artery evaluation and lung screening.

    Methods: We studied 30 current or former heavy smoker subjects with suspected or known coronary artery disease who underwent CT assessment of both coronary arteries and thoracic area (Revolution CT, General Electric). Read More

    The impact of nontraditional lipid profiles on left ventricular geometric abnormalities in general Chinese population.
    BMC Cardiovasc Disord 2018 May 8;18(1):88. Epub 2018 May 8.
    Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.
    Background: Despite current interest in the unfavorable impact of nontraditional lipid profiles on cardiovascular disease, information regarding its relations to abnormal left ventricular (LV) geometry has not been systemically elucidated. This study sought to understand predictive implication of nontraditional lipid profiles in specific LV geometric patterns in the general population of rural China.

    Methods: Analyses were based upon a cross-sectional study of 10,756 participants (mean age 53. Read More

    Safety of cilostazol in peripheral artery disease: a cohort from a primary healthcare electronic database.
    BMC Cardiovasc Disord 2018 May 8;18(1):85. Epub 2018 May 8.
    Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAPJGol), Gran Via de les Corts Catalanes 587, àtic, 08007, Barcelona, Spain.
    Background: Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events or haemorrhages in patients with peripheral artery disease treated with cilostazol in comparison to pentoxifylline users.

    Methods: Population-based cohort study including all individuals older than 40 who initiated cilostazol or pentoxifylline during 2009-2011 in SIDIAP database. Read More

    Novel functional advanced echocardiography for the assessment of myocardial mechanics in children with neurocardiogenic syncope - a blinded prospective speckle tracking head-up tilt-table challenge study.
    BMC Cardiovasc Disord 2018 May 8;18(1):87. Epub 2018 May 8.
    HELIOS University Medical Center Wuppertal, Children's Hospital, Center for Clinical & Translational Research (CCTR), Faculty of Health, Center for Biomedical Education & Research (ZBAF), Witten/Herdecke University, Faculty of Health, Heusnerstr. 40, D-42283, Wuppertal, Germany.
    Background: Data on left ventricular (LV) function in patients with neurocardiogenic syncope (NS) is conflicting in adults and lacking in children. The aim of this study was to analyze LV myocardial performance in children with NS at rest and during head-up tilt-table (HUTT) testing.

    Methods: This is the first study to combine HUTT and speckle-tracking echocardiography (STE) in children with NS. Read More

    Association between skeletal muscle mass to visceral fat area ratio and arterial stiffness in Chinese patients with type 2 diabetes mellitus.
    BMC Cardiovasc Disord 2018 May 8;18(1):89. Epub 2018 May 8.
    Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, Zhejiang Province, 325000, People's Republic of China.
    Background: The skeletal muscle mass-to-visceral fat area ratio (SVR) has been linked to arterial stiffness in non-diabetic adults. We examined the association between the SVR and arterial stiffness in patients with type 2 diabetes mellitus (T2DM).

    Methods: Patients with type 2 diabetes mellitus (252 men and 171 women) aged 40-75 years were enrolled and divided into three groups according to SVR tertiles. Read More

    Effect of blood pressure and total cholesterol measurement on risk prediction using the Systematic COronary Risk Evaluation (SCORE).
    BMC Cardiovasc Disord 2018 May 4;18(1):84. Epub 2018 May 4.
    German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Fleischmannstr. 42-44, 17475, Greifswald, Germany.
    Background: To compare the reproducibility in total cholesterol (TC), systolic blood pressure (BP), and the resulting Systematic COronary Risk Evaluation (SCORE) obtained by an in-office cardio-preventive screening program (SP) and a subsequent program performed in a clinical trial examination center (EP).

    Methods: A total of 307 individuals (60.3% female, mean age = 52. Read More

    The comorbidity of increased arterial stiffness and microalbuminuria in a survey of middle-aged adults in China.
    BMC Cardiovasc Disord 2018 May 4;18(1):83. Epub 2018 May 4.
    Department of Health Management, the Third Xiangya Hospital, Central South University, Tongzipo Road 138, Changsha, 410013, Hunan Province, China.
    Background: Increased arterial stiffness (iAS) and microalbuminuria (MAU), which may occur simultaneously or separately in the general population and share similar risk factors, are markers of macro- and microvascular injuries. Our research investigated the comorbidity of iAS and MAU in the middle-aged population and examined the heterogeneous effects of metabolic risk factors on iAS and MAU.

    Methods: We selected 11,911 individuals aged 45 to 60 years who underwent a health examination at the 3rd Xiangya Hospital between 2010 and 2014. Read More

    Prevalence and characteristics of primary left-sided valve disease in a cohort of 15,000 patients undergoing echocardiography studies in a tertiary hospital in Uganda.
    BMC Cardiovasc Disord 2018 May 4;18(1):82. Epub 2018 May 4.
    Uganda Heart Institute, Kampala, Uganda.
    Background: Although rheumatic heart disease remains the leading cause of valve heart disease (VHD) in developing countries, other forms of valve disease have been over shadowed and not regarded as a public health problem. However, several facts suggest that the role of non-rheumatic VHD as a significant cardiovascular disease should be reconsidered. We aimed to assess the prevalence and characteristics of different forms of primary left sided valve diseases from a series of 15,009 echocardiographic studies. Read More

    A new method for the assessment of endothelial function with peripheral arterial volume.
    BMC Cardiovasc Disord 2018 May 4;18(1):81. Epub 2018 May 4.
    Department of Cardiology, Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, China-Japan Union Hospital of Jilin University, Xiantai Street NO.126, Changchun, Jilin, China.
    Background: Currently, many methodological approaches have been developed to assess peripheral endothelial function. However, a development of the noninvasive and automated technique for routinely assessing endothelial function is still required. We evaluated the potential value of a new method to measure peripheral endothelial function with reactive hyperemia peripheral arterial volume (RH-PAV) in patients with chest pain. Read More

    Signs, symptoms, and treatment patterns across serial ambulatory cardiology visits in patients with heart failure: insights from the NCDR PINNACLE® registry.
    BMC Cardiovasc Disord 2018 May 3;18(1):80. Epub 2018 May 3.
    Health Economics & Outcomes Research, Novartis Pharmaceuticals Corporation, One Health Plaza 125/3410B, East Hanover, NJ, 07936-1080, USA.
    Background: Due to a relative lack of outpatient heart failure (HF) clinical registries, we aimed to describe symptoms, signs, and medication treatment among ambulatory patients with heart failure (HF) over time.

    Methods: Using health records from 234 PINNACLE (Practice Innovation and Clinical Excellence) U.S. Read More

    "As du Coeur" study: a randomized controlled trial on physical activity maintenance in cardiovascular patients.
    BMC Cardiovasc Disord 2018 May 2;18(1):77. Epub 2018 May 2.
    Université Côte d'Azur, LAMHESS, Nice, France.
    Background: The benefits of supervised physical activity programs in cardiac rehabilitation have been amply demonstrated, but the quantity of physical activity often declines quickly once supervision ends. This trial assesses the effectiveness of an experimental intervention drawing on habit formation theory to maintain physical activity.

    Methods: Cardiovascular patients (N = 47) were randomly assigned to one of two groups. Read More

    Post percutaneous coronary interventional adverse cardiovascular outcomes and bleeding events observed with prasugrel versus clopidogrel: direct comparison through a meta-analysis.
    BMC Cardiovasc Disord 2018 May 2;18(1):78. Epub 2018 May 2.
    Institute of Cardiovascular Diseases and Guangxi Key Laboratory Base of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
    Background: Due to limitations associated with clopidogrel following percutaneous coronary intervention (PCI), other newer oral anti-platelet agents are being studied. We aimed to systematically carry out a direct comparison of outcomes observed with prasugrel versus clopidogrel following PCI.

    Methods: Common online searched databases (The Cochrane library, EMBASE, MEDLINE and Google scholar) were used to retrieve relevant publications. Read More

    Three-dimensional thoracic aorta principal strain analysis from routine ECG-gated computerized tomography: feasibility in patients undergoing transcatheter aortic valve replacement.
    BMC Cardiovasc Disord 2018 May 2;18(1):76. Epub 2018 May 2.
    Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, South Health Campus, 4448 Front Street SE, Calgary, Alberta, T3M 1M4, Canada.
    Background: Functional impairment of the aorta is a recognized complication of aortic and aortic valve disease. Aortic strain measurement provides effective quantification of mechanical aortic function, and 3-dimenional (3D) approaches may be desirable for serial evaluation. Computerized tomographic angiography (CTA) is routinely performed for various clinical indications, and offers the unique potential to study 3D aortic deformation. Read More

    Regional myocardial motion in patients with mild cognitive impairment: a pilot study.
    BMC Cardiovasc Disord 2018 May 2;18(1):79. Epub 2018 May 2.
    Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Ste 1600, Chicago, IL, 60611, USA.
    Background: Cardiovascular disease (CVD) is a risk factor for cognitive impairment in the elderly. Manifestations of subclinical CVDs can be found in patients with cognitive impairment. The aim of the present study was to test the hypothesis that patients with mild cognitive impairment (MCI) have different magnetic resonance imaging (MRI)-derived regional myocardial motion indices compared with healthy controls. Read More

    Cost-of-illness studies in heart failure: a systematic review 2004-2016.
    BMC Cardiovasc Disord 2018 May 2;18(1):74. Epub 2018 May 2.
    Centre for Health Technology Assessment (HTA) and Public Health (IZPH), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
    Background: Heart failure is a major and growing medical and economic problem worldwide as 1-2% of the healthcare budget are spent for heart failure. The prevalence of heart failure has increased over the past decades and it is expected that there will be further raise due to the higher proportion of elderly in the western societies. In this context cost-of-illness studies can significantly contribute to a better understanding of the drivers and problems which lead to the increasing costs in heart failure. Read More

    Predictive value of neutrophil to lymphocyte ratio in patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention: a meta-analysis.
    BMC Cardiovasc Disord 2018 May 2;18(1):75. Epub 2018 May 2.
    Department of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
    Background: The neutrophil to lymphocyte ratio (NLR) is an indicator of systemic inflammation and a prognostic marker in patients with acute coronary syndrome (ACS). This study aims to investigate the value of NLR to predict the in-hospital and long-term prognosis in patients with ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) by meta-analysis.

    Method: The studies related to the prognosis of NLR and STEMI patients published in the Pubmed, Embase, and Ovid databases before June 2017 were retrieved. Read More

    Association between anthropometric measures and cardiovascular disease (CVD) risk factors in Hainan centenarians: investigation based on the Centenarian's health study.
    BMC Cardiovasc Disord 2018 May 2;18(1):73. Epub 2018 May 2.
    Hainan Branch of PLA General Hospital, Sanya, 572000, China.
    Background: Centenarians refer to a special group who have outlived most of their fellows. Body shape and abdominal obesity have been identified as cardiovascular disease (CVD) risk factors. Our study aimed to evaluate the relationship between body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) and CVD risk factors among male and female centenarians in Hainan province. Read More

    SHP2 inhibitor PHPS1 protects against atherosclerosis by inhibiting smooth muscle cell proliferation.
    BMC Cardiovasc Disord 2018 Apr 27;18(1):72. Epub 2018 Apr 27.
    Department of Cardiology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Friendship Road 181, Baoshan District, Shanghai, China.
    Background: Smooth muscle cells play an important role in the development of atherosclerosis. SHP2 is known to regulate the proliferation and migration of smooth muscle cells. The purpose of this study was to determine whether the SHP2 inhibitor PHPS1 has a pro-atherosclerotic or an atheroprotective effect in vivo and in vitro. Read More

    Periprocedural anticoagulation during left atrial ablation: interrupted and uninterrupted vitamin K-antagonists or uninterrupted novel anticoagulants.
    BMC Cardiovasc Disord 2018 Apr 27;18(1):71. Epub 2018 Apr 27.
    Medizinische Klinik IV, Städtisches Klinikum Karlsruhe, Academic Teaching Hospital of the University of Freiburg, Moltkestrasse 90, 76133, Karlsruhe, Germany.
    Background: There is a lack of data on anticoagulation requirements during ablation of atrial fibrillation (AF). This study compares different oral anticoagulation (OAC) strategies to evaluate risk of bleeding and thromboembolic complications.

    Methods: We conducted a single-centre study in patients undergoing left atrial ablation of AF. Read More

    In-flight angina pectoris; an unusual presentation.
    BMC Cardiovasc Disord 2018 Apr 5;18(1):61. Epub 2018 Apr 5.
    Essex Cardiothoracic Centre, Basildon Hospital, Nethermayne, Basildon, Essex, SS16 5NL, UK.
    Background: An unusual case of typical angina which occurred on a long haul flight is presented. This case is notable as this was the index presentation, with no previous symptoms prior to this. Physiological changes at altitude can be marked, and include hypoxia, tachycardia and an increase in cardiac output. Read More

    Prediction of clinical outcome in patients treated with cardiac resynchronization therapy - the role of NT-ProBNP and a combined response score.
    BMC Cardiovasc Disord 2018 Apr 24;18(1):70. Epub 2018 Apr 24.
    Department of Clinical Sciences, Arrhythmia section, Lund University, Skane University Hospital, Lund, Sweden.
    Background: Cardiac resynchronization therapy (CRT) is an established therapy for appropriately selected patients with heart failure. Response to CRT has been heterogeneously defined using both clinical and echocardiographic measures, with poor correlation between the two.

    Methods: The study cohort was comprised of 202 CRT-treated patients and CRT response was defined at 6 months post-implant. Read More

    Thrombus aspiration in patients with ST-elevation myocardial infarction: results of a national registry of interventional cardiology.
    BMC Cardiovasc Disord 2018 Apr 24;18(1):69. Epub 2018 Apr 24.
    Hospital de Santa Cruz. CHLO; Departamento de Fisiopatologia Nova Medical School, Lisboa, Portugal.
    Background: We aimed to evaluate the impact of thrombus aspiration (TA) during primary percutaneous coronary intervention (P-PCI) in 'real-world' settings.

    Methods: We performed a retrospective study, using data from the National Registry of Interventional Cardiology (RNCI 2006-2012, Portugal) with ST-elevation myocardial infarction (STEMI) patients treated with P-PCI. The primary outcome, in-hospital mortality, was analysed through adjusted odds ratio (aOR) and 95% confidence intervals (95%CI). Read More

    Dietary diversity score is associated with cardiovascular risk factors and serum adiponectin concentrations in patients with metabolic syndrome.
    BMC Cardiovasc Disord 2018 Apr 17;18(1):68. Epub 2018 Apr 17.
    Tabriz Health Services Management Research Center, Health Education and Health Promotion Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Metabolic syndrome is associated with cardio-metabolic risk factors and lipid abnormalities. Previous studies evaluated the dietary habits and nutrient intakes among patients with metabolic syndrome; however the association between metabolic risk factors and adiponectin with dietary diversity score (DDS) in patients with metabolic syndrome has not been evaluated yet. Therefore the aim of the current study was to evaluate these relationships among patients with metabolic syndrome. Read More

    N-terminal pro-B-type natriuretic peptide and microsize myocardial infarction risk in the reasons for geographic and racial differences in stroke study.
    BMC Cardiovasc Disord 2018 Apr 16;18(1):66. Epub 2018 Apr 16.
    Division of General Internal Medicine, Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, P.O. Box 46, New York, N.Y 10065, USA.
    Background: N-terminal pro B-type peptide (NT-proBNP) has been associated with risk of myocardial infarction (MI), but less is known about the relationship between NT-proBNP and very small non ST-elevation MI, also known as microsize MI. These events are now routinely detectable with modern troponin assays and are emerging as a large proportion of all MI. Here, we sought to compare the association of NT-proBNP with risk of incident typical MI and microsize MI in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Read More

    A moderate 500-m treadmill walk for estimating peak oxygen uptake in men with NYHA class I-II heart failure and reduced left ventricular ejection fraction.
    BMC Cardiovasc Disord 2018 Apr 16;18(1):67. Epub 2018 Apr 16.
    Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy.
    Background: Maximal cardiopulmonary exercise testing (CPX) is the gold-standard for cardiorespiratory fitness assessment in chronic heart failure (CHF) patients. However, high costs, required medical supervision, and safety concerns make maximal exercise testing impractical for evaluating mobility-impaired adults. Thus, several submaximal walking protocols have been developed and currently used to estimate peak oxygen consumption (VOpeak) in CHF patients. Read More

    Increased circulating chemerin in patients with advanced carotid stenosis.
    BMC Cardiovasc Disord 2018 Apr 13;18(1):65. Epub 2018 Apr 13.
    Research Laboratories; Clinic for Visceral, Transplantation, Thoracic and Vascular Surgery, Leipzig University, Liebigstr. 19, D-04103, Leipzig, Germany.
    Background: Chemerin is an adipokine which plays a crucial role in atherosclerosis. Here, we examined whether circulating chemerin is enhanced in patients with advanced carotid stenosis.

    Methods: Chemerin was quantified in 178 patients prior to carotid end arterectomy (CEA) and in age- and gender-matched controls (n = 163). Read More

    Atrophic inferior vena cava is a marker of chronicity of intra-filter and inferior vena cava thrombosis: based on CT findings.
    BMC Cardiovasc Disord 2018 Apr 11;18(1):64. Epub 2018 Apr 11.
    Vascular and Interventional Radiology, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing, 210006, China.
    Background: A permanently indwelling filter in the inferior vena cava (IVC) may induce caval thrombosis, which could develop and evolve from an acute to a chronic phase. The differential diagnosis of acute and chronic thromboses determines the treatment strategy. The role of computed tomography (CT) in diagnosing acute and chronic intra-filter and IVC thromboses has not been well established. Read More

    Metformin restores electrophysiology of small conductance calcium-activated potassium channels in the atrium of GK diabetic rats.
    BMC Cardiovasc Disord 2018 Apr 10;18(1):63. Epub 2018 Apr 10.
    Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.
    Background: Small conductance calcium-activated potassium channels (SK channels) play a critical role in action potential repolarization in cardiomyocytes. Recently, the potential anti-arrhythmic effect of metformin in diabetic patients has been recognized, yet the underlying mechanism remains elusive.

    Methods: Diabetic Goto-Kakizaki (GK) rats were untreated or treated with metformin (300 mg/kg/day) for 12 weeks, and age-matched Wistar rats were used as control (n = 6 per group). Read More

    Gender-specific contribution of cardiometabolic index and lipid accumulation product to left ventricular geometry change in general population of rural China.
    BMC Cardiovasc Disord 2018 Apr 10;18(1):62. Epub 2018 Apr 10.
    Department of Hematology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.
    Background: Despite current interest in the unfavorable impact of cardiometabolic index (CMI) and lipid accumulation product (LAP) on diabetes and cardiovascular risk, information regarding the relation of CMI and LAP to left ventricular (LV) geometry has not been specifically addressed. We aimed to examine the hypothesis: (1) CMI and LAP represent an independent determinant of LV remodeling in general population of rural China; (2) there are gender differences in obesity-related alterations in terms of LV morphology.

    Methods: The sample for this cross-sectional analysis included 11,258 participants (mean age 53. Read More

    Primary results of abdominal aortic aneurysm screening in the at-risk residents in middle China.
    BMC Cardiovasc Disord 2018 Apr 3;18(1):60. Epub 2018 Apr 3.
    Department of Vascular and Endovascular Surgery, Henan Provincial People's Hospital, Fuwai Central China Cardiovascular Hospital, NO.7 Weiwu Road, Zhengzhou, 450003, Henan, People's Republic of China.
    Background: There is a lack of information on the epidemiological data and risk factors associated with abdominal aortic aneurysm (AAA) in Chinese population. We reported the primary results from screening five-community population in Middle China for AAA.

    Methods: From March 2014 to October 2015, an AAA screening program was performed in three urban and two rural communities. Read More

    Long-term effects on cardiovascular risk of a structured multidisciplinary lifestyle program in clinical practice.
    BMC Cardiovasc Disord 2018 Apr 2;18(1):59. Epub 2018 Apr 2.
    The Swedish School of Sport and Health Sciences, Stockholm, Sweden.
    Background: Cardiovascular disease is still the leading cause of premature death world-wide with factors like abdominal obesity, hypertension and dyslipidemia being central risk factors in the etiology. The aim of the present study was to investigate the effects on cardiovascular risk factors and cardiovascular risk after 6 months and 1 year, in individuals with increased cardiovascular risk enrolled in a lifestyle multidisciplinary program in a clinical setting.

    Method: Individuals with increased cardiovascular risk were referred from primary health care and hospitals to a program at an outpatient clinic at a department of cardiology. Read More

    Relationship of cardiovascular disease risk factors and noncoding RNAs with hypertension: a case-control study.
    BMC Cardiovasc Disord 2018 Apr 2;18(1):58. Epub 2018 Apr 2.
    Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, No. 1, Xueyuan Road, Fuzhou, 350122, Fujian, China.
    Background: The present study sought to explore the relationship of common cardiovascular disease risk factors and noncoding RNAs with essential hypertension (EH).

    Methods: A total of 402 EH patients and 402 gender- and age-frequency matched healthy controls were enrolled in this study. Each participant received a questionnaire survey, physical examination and laboratory tests. Read More

    Study protocol, randomized controlled trial: reducing symptom burden in patients with heart failure with preserved ejection fraction using ubiquinol and/or D-ribose.
    BMC Cardiovasc Disord 2018 Apr 2;18(1):57. Epub 2018 Apr 2.
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA.
    Background: Heart failure (HF), the leading cause of morbidity and mortality in the US, affects 6.6 million adults with an estimated additional 3 million people by 2030. More than 50% of HF patients have heart failure with preserved left ventricular ejection fraction (HFpEF). Read More

    Characteristics of exercise capacity in female systemic lupus erythematosus associated pulmonary arterial hypertension patients.
    BMC Cardiovasc Disord 2018 Mar 23;18(1):56. Epub 2018 Mar 23.
    Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China.
    Background: To study the oxygen uptake efficiency and determine usefulness of submaximal parameters of oxygen uptake in systemic lupus erythematosus associated pulmonary arterial hypertension (SLE PAH) on performing a cardiopulmonary exercise test (CPET).

    Methods: CPET was performed in 21 SLE PAH patients, equal number of idiopathic pulmonary arterial hypertension (IPAH) patients and controls. Peak VO, anaerobic threshold (AT), oxygen uptake efficiency slope (OUES) and oxygen uptake efficiency plateau (OUEP) and other CPET parameters were examined. Read More

    Emergency transcatheter aortic valve replacement for a patient with decompensated severe aortic stenosis accompanied by cardiorenal syndrome: a case report.
    BMC Cardiovasc Disord 2018 Mar 20;18(1):55. Epub 2018 Mar 20.
    Division of Cardiology, Yeungnam University Medical Center, Yeungnam University College of Medicine, 3170, Hyeonchung-ro, Nam-gu, Daegu, South Korea.
    Background: Severe aortic stenosis (AS) may lead to acute decompensated heart failure resistant to medical treatment. Here, we report a successful emergent transcatheter aortic valve replacement (TAVR) in a patient presenting with decompensated severe AS accompanied by cardiorenal syndrome.

    Case Presentation: A 82-year-old man presented at our emergency department with aggravated dyspnea. Read More

    Clinical outcomes associated with catecholamine use in patients diagnosed with Takotsubo cardiomyopathy.
    BMC Cardiovasc Disord 2018 Mar 20;18(1):54. Epub 2018 Mar 20.
    First Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
    Background: Recent hypotheses have suggested the pathophysiological role of catecholamines in the evolution of the Takotsubo syndrome (TTS). The extent of cardiac and circulatory compromise dictates the use of some form of supportive therapy. This study was designed to investigate the clinical outcomes associated with catecholamine use in TTS patients. Read More

    Comprehensive microRNA profiling reveals potential augmentation of the IL1 pathway in rheumatic heart valve disease.
    BMC Cardiovasc Disord 2018 Mar 16;18(1):53. Epub 2018 Mar 16.
    Department of Cardiothoracic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650101, China.
    Background: Valvular heart disease is a leading cause of cardiovascular mortality, especially in China. More than a half of valvular heart diseases are caused by acute rheumatic fever. microRNA is involved in many physiological and pathological processes. Read More

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