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    1608 results match your criteria BMC Cardiovascular Disorders[Journal]

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    A study of the association of rs12040273 with susceptibility and severity of coronary artery disease in a Chinese Han population.
    BMC Cardiovasc Disord 2018 Jan 19;18(1):10. Epub 2018 Jan 19.
    Department of Cardiology, Affiliated Sixth People's Hospital East, Shanghai University of Medicine and Health Sciences; Shanghai Jiao Tong University Affiliated Sixth People's Hospital East, No. 222 Huanhu Xisan Road, Shanghai, 201306, China.
    Background: The single nucleotide polymorphism (SNP) rs12040273, a variant of UDP-N-acetylgalactosamine, polypeptide GalNAc-transferase 2, has recently been reported to be significantly associated with development of carotid artery intima-media thickness (IMT) in a Chinese population based on a genome-wide association study. Because IMT is a potent marker of coronary artery disease (CAD), the aim of this study was to evaluate the relation of rs12040273 to susceptibility and severity of CAD in a Chinese Han population.

    Methods: We performed a hospital-based case-control study. Read More

    Oscillometric blood pressure by age and height for non overweight children and adolescents in Lubumbashi, Democratic Republic of Congo.
    BMC Cardiovasc Disord 2018 Jan 19;18(1). Epub 2018 Jan 19.
    Department of Clinical Epidemiology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
    Background: The diagnosis of hypertension in children is complex because based on normative values by sex, age and height, and these values vary depending on the environment. Available BP references used, because of the absence of local data, do not correspond to our pediatric population. Accordingly, our study aimed to provide the BP threshold for children and adolescents in Lubumbashi (DRC) and to compare them with German (KIGGS study), Polish (OLAF study) and Chinese (CHNS study) references. Read More

    Blood lactate is a predictor of short-term mortality in patients with myocardial infarction complicated by heart failure but without cardiogenic shock.
    BMC Cardiovasc Disord 2018 Jan 18;18(1). Epub 2018 Jan 18.
    Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, SE-221 81, Lund, Sweden.
    Background: Mortality in patients with acute myocardial infarction (AMI) has improved substantially with modern therapy including percutaneous coronary interventions (PCI) but remains high in certain subgroups such as patients presenting with overt cardiogenic shock. However, the risk for AMI in patients presenting acutely with signs of heart failure but without cardiogenic shock is less well described. We aimed to identify risk factors for mortality in AMI patients with heart failure without overt cardiogenic shock. Read More

    A simple prediction model to estimate obstructive coronary artery disease.
    BMC Cardiovasc Disord 2018 Jan 16;18(1). Epub 2018 Jan 16.
    The George Institute for Global Health, University of Sydney, Camperdown, NSW, 2050, Australia.
    Background: A simple noninvasive model to predict obstructive coronary artery disease (OCAD) may promote risk stratification and reduce the burden of coronary artery disease (CAD). This study aimed to develop pre-procedural, noninvasive prediction models that better estimate the probability of OCAD among patients with suspected CAD undergoing elective coronary angiography (CAG).

    Methods: We included 1262 patients, who had reliable Framingham risk variable data, in a cohort without known CAD from a prospective registry of patients referred for elective CAG. Read More

    Early commitment of cardiovascular autonomic modulation in Brazilian patients with congenital generalized lipodystrophy.
    BMC Cardiovasc Disord 2018 Jan 12;18(1). Epub 2018 Jan 12.
    Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
    Background: Metabolic abnormalities in congenital generalized lipodystrophy (CGL) are associated with microvascular complications. However, the evaluation of different types of neuropathy in these patients, including the commitment of cardiovascular autonomic modulation, is scarce. The objective of the present study was to determine the prevalence of cardiovascular autonomic neuropathy (CAN) in patients with CGL compared with individuals with type 1 diabetes and healthy subjects. Read More

    Correction to: Short- and long-term outcomes in infective endocarditis patients: a systematic review and meta-analysis.
    BMC Cardiovasc Disord 2018 Jan 12;18(1). Epub 2018 Jan 12.
    Department of Clinical pharmacy, School of Phamacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Correction: Unfortunately, after publication of this article [1], it was noticed that the name of the fifth author was incorrectly displayed as Akshaya Srikanth Bahagavathula. The correct name is Akshaya Srikanth Bhagavathula and can be seen in the corrected author list above. The original article has also been updated to correct this error. Read More

    Effect of intracoronary agents on the no-reflow phenomenon during primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction: a network meta-analysis.
    BMC Cardiovasc Disord 2018 Jan 10;18(1). Epub 2018 Jan 10.
    Department of Cardiology, the First Hospital of Lanzhou University, Donggang West Road, No. 1, Lanzhou, Gansu, 730000, China.
    Background: Despite the restoration of epicardial flow after primary percutaneous coronary intervention (PPCI), myocardial reperfusion remains impaired in a significant proportion of patients. We performed a network meta-analysis to assess the effect of 7 intracoronary agents (adenosine, anisodamine, diltiazem, nicorandil, nitroprusside, urapidil, and verapamil) on the no-reflow phenomenon in patients with ST-elevation myocardial infarction (STEMI) undergoing PPCI.

    Methods: Database searches were conducted to identify randomized controlled trials (RCTs) comparing the 7 agents with each other or with standard PPCI. Read More

    Independent association of resting energy expenditure with blood pressure: confirmation in populations of the African diaspora.
    BMC Cardiovasc Disord 2018 Jan 10;18(1). Epub 2018 Jan 10.
    Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
    Background: Obesity is a major risk factor for hypertension, however, the physiologic mechanisms linking increased adiposity to elevations in blood pressure are not well described. An increase in resting energy expenditure (REE) is an obligatory consequence of obesity. Previous survey research has demonstrated that REE is an independent predictor of blood pressure, and eliminates the co-linear association of body mass index. Read More

    Association of rs662799 in APOA5 with CAD in Chinese Han population.
    BMC Cardiovasc Disord 2018 Jan 8;18(1). Epub 2018 Jan 8.
    Department of Cardiology, Inner Mongolia Medical University, Huhehaote, Inner Mongolia, China.
    Background: CAD (Coronary Artery Disease) is a complex disease that influenced by various environmental and genetic factors. Previous studies have found many single nucleotide polymorphisms (SNPs) associated with the risk of CAD occurrence. However, the results are inconsistent. Read More

    Comprehensive geriatric assessment in patients undergoing transcatheter aortic valve implantation - results from the CGA-TAVI multicentre registry.
    BMC Cardiovasc Disord 2018 Jan 4;18(1). Epub 2018 Jan 4.
    Department of Geriatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    Background: In older patients with aortic stenosis (AS) undergoing TAVI, the potential role of prior CGA is not well established. To explore the value of comprehensive geriatric assessment (CGA) for predicting mortality and/or hospitalisation within the first 3 months after transcatheter aortic valve implantation (TAVI).

    Methods: An international, multi-centre, prospective registry (CGA-TAVI) was established to gather data on CGA results and medium-term outcomes in geriatric patients undergoing TAVI. Read More

    Lower diastolic wall strain is associated with coronary revascularization in patients with stable angina.
    BMC Cardiovasc Disord 2017 Dec 28;17(1):301. Epub 2017 Dec 28.
    Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea.
    Background: Left ventricular (LV) diastolic dysfunction occurs earlier in the ischemic cascade than LV systolic dysfunction and electrocardiographic changes. Diastolic wall strain (DWS) has been proposed as a marker of LV diastolic stiffness. Therefore, the objectives of this study were to define the relationship between DWS and coronary revascularization and to evaluate other echocardiographic parameters in patients with stable angina who were undergoing coronary angiography (CAG). Read More

    The utility of personal activity trackers (Fitbit Charge 2) on exercise capacity in patients post acute coronary syndrome [UP-STEP ACS Trial]: a randomised controlled trial protocol.
    BMC Cardiovasc Disord 2017 Dec 29;17(1):303. Epub 2017 Dec 29.
    MonashHeart, Monash Health and Monash Cardiovascular Research Centre, 246 Clayton Road, Clayton, Melbourne, VIC, 3168, Australia.
    Background: The benefits of physical activity and cardiovascular rehabilitation on the reduction of cardiovascular risk are well documented. Despite this, significant barriers and challenges remain in optimizing patient risk factors post acute coronary syndromes (ACS) and ensuring patient compliance. Consumer wearable personal activity trackers represent a cost effective and readily available technology that may aid in this endeavour. Read More

    Medium-term outcomes of 78,808 patients after heart valve surgery in a middle-income country: a nationwide population-based study.
    BMC Cardiovasc Disord 2017 Dec 28;17(1):302. Epub 2017 Dec 28.
    University Hospital and School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
    Background: Heart valve surgery outcomes are unknown in middle-income countries and thus cannot be used in health system decision making processes. This study estimated in-hospital mortality and medium and long-term survival.

    Methods: This was a retrospective study of 78,806 patients who underwent heart valve surgery between 2001 and 2007 in Brazil. Read More

    Retinal capillary rarefaction in patients with untreated mild-moderate hypertension.
    BMC Cardiovasc Disord 2017 Dec 21;17(1):300. Epub 2017 Dec 21.
    Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany.
    Background: Microvascular rarefaction influences peripheral vascular resistance, perfusion and metabolism by affecting blood pressure and flow pattern. In hypertension microvascular rarefaction has been described in experimental animal studies as well as in capillaroscopy of skin and biopsies of muscle tissue in patients. Retinal circulation mirrors cerebral microcirculation and allows non-invasive investigations. Read More

    Takotsubo syndrome - adding pieces to a complex puzzle.
    BMC Cardiovasc Disord 2017 Dec 20;17(1):296. Epub 2017 Dec 20.
    Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.
    Takotsubo syndrome, a form of acutely decompensated heart failure, has drawn interest because of its intriguing pathophysiology and therapeutic dilemmas. In their recent work in BMC Cardiovascular Disorders, Abanador-Kamper et al. describe the therapy management in these patients and add valuable information on cardiovascular magnetic resonance imaging evolution. Read More

    Eosinophilic granulomatosis with polyangiitis: myocardial thickening reversed by corticosteroids.
    BMC Cardiovasc Disord 2017 Dec 20;17(1):299. Epub 2017 Dec 20.
    Centre for Research and Development, Uppsala University/Region Gävleborg, SE-801 87, Gävle, Sweden.
    Background: In 1951 Churg and Strauss first described the clinical condition now known as eosinophilic granulomatosis with polyangiitis (EGPA), characterized by asthma, nasal polyposis, rhinosinusitis, hypereosinophilia with organ infiltration, and necrotizing vasculitis. It is classified as an antineutrophil cytoplasmic antibody (ANCA) associated vasculitis, but ANCA negativity is common and more frequently encountered in EGPA with myocardial involvement. Long-term survival has substantially improved with corticosteroid treatment but myocardial involvement is still the leading cause of death in EGPA. Read More

    The combined impact of mechanical factors on the wall stress of the human ascending aorta - a finite elements study.
    BMC Cardiovasc Disord 2017 12 20;17(1):297. Epub 2017 Dec 20.
    Department of Biomedical Engineering, Mechatronics and Theory of Mechanisms, Wroclaw University of Science and Technology, Wroclaw, Poland.
    Background: Biomechanical factors influence stress in the aortic wall. The aim of this study was to assess how the diameter and shape of the vessel, blood pressure and longitudinal systolic aortic stretching (SAS) caused by the contraction of the myocardium influence stress in the aortic wall.

    Methods: Three computational models of the non-dilated aorta and aneurysms of the ascending aorta and aortic root were created. Read More

    Analysis of cardiovascular mortality, bleeding, vascular and cerebrovascular events in patients with atrial fibrillation vs. sinus rhythm undergoing transfemoral Transcatheter Aortic Valve Implantation (TAVR).
    BMC Cardiovasc Disord 2017 Dec 20;17(1):298. Epub 2017 Dec 20.
    Department of Internal Medicine/Cardiology and Angiology, Otto-von-Guericke University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
    Background: Transcatheter aortic valve replacement (TAVR) has been demonstrated to be an established therapy for high-risk, inoperable patients with severe symptomatic aortic valve stenosis. For patients with moderate surgical risk, TAVR is equivalent to conventional aortic valve surgery. However, atrial fibrillation (AF) is also present in many of these patients, thus requiring post-implantation oral anticoagulation therapy in addition to the inhibition of thrombocyte aggregation, which poses the risk of bleeding complications. Read More

    Periprocedural heparin bridging in patients receiving oral anticoagulation: a systematic review and meta-analysis.
    BMC Cardiovasc Disord 2017 Dec 13;17(1):295. Epub 2017 Dec 13.
    Beijing Institute of Heart Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-related Cardiovascular Disease, Ministry of Education, Anzhen Hospital, Capital Medical University, Beijing, China.
    Background: Periprocedural heparin bridging therapy aims to reduce the risk of thromboembolic events in patients requiring an interruption in their anticoagulation therapy for the purpose of an elective procedure. The efficacy and safety of heparin bridging therapy has not been well established.

    Objectives: To compare through meta-analysis the effects of heparin bridging therapy on the risk of major bleeding and thromboembolic events of clinical significance among patients taking oral anticoagulants. Read More

    Basal wall hypercontraction of Takotsubo cardiomyopathy in a patient who had been diagnosed with dilated cardiomyopathy: a case report.
    BMC Cardiovasc Disord 2017 Dec 12;17(1):293. Epub 2017 Dec 12.
    Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan.
    Background: Takotsubo cardiomyopathy is characterized by the basal hypercontractility and apical ballooning of the left ventriculum and T-wave inversion in the electrocardiogram. It has been suggested that Takotsubo cardiomyopathy might underlie the pathogenesis of persistent cardiac dysfunction; however, few reports are present demonstrating the advent of Takotsubo cardiomyopathy in patients with idiopathic cardiomyopathy.

    Case Presentation: A 64-year-old women was admitted due to dyspnea on effort and lower extremity edema. Read More

    Short- and long-term outcomes in infective endocarditis patients: a systematic review and meta-analysis.
    BMC Cardiovasc Disord 2017 Dec 12;17(1):291. Epub 2017 Dec 12.
    Department of Clinical pharmacy, School of Phamacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Background: Despite advances in medical knowledge, technology and antimicrobial therapy, infective endocarditis (IE) is still associated with devastating outcomes. No reviews have yet assessed the outcomes of IE patients undergoing short- and long-term outcome evaluation, such as all-cause mortality and IE-related complications. We conducted a systematic review and meta-analysis to examine the short- and long-term mortality, as well as IE-related complications in patients with definite IE. Read More

    Heart rate variability after radiofrequency ablation of epicardial ganglionated plexuses on the ovine left atrium.
    BMC Cardiovasc Disord 2017 Dec 12;17(1):292. Epub 2017 Dec 12.
    Lithuanian University of Health Sciences, Eivenių 2, LT-50161, Kaunas, Lithuania.
    Background: Ganglionated plexuses (GP) are terminal parts of cardiac autonomous nervous system (ANS). Radiofrequency ablation (RFA) for atrial fibrillation (AF) possibly affects GP. Changes in heart rate variability (HRV) after RFA can reflect ANS modulation. Read More

    Left atrial enlargement and clinical considerations in patients with or without a residual interatrial shunt after closure of the left atrial appendage with the WATCHMAN™-device.
    BMC Cardiovasc Disord 2017 Dec 12;17(1):294. Epub 2017 Dec 12.
    Department of Internal Medicine, Division of Cardiology and Angiology, Magdeburg University, Leipzigerstr. 44, 39120, Magdeburg, Germany.
    Background: Interventional closure of the left atrial appendage (LAA) in patients with non-valvular atrial fibrillation, high thromboembolic and bleeding risk or bleeding history is an alternative therapeutic strategy to oral anticoagulation. It is not known if the exclusion of the LAA from the blood circulation affects the left atrial volume (LAV) and consequently its prognostic value or the circulatory performance of the heart in humans.

    Methods: We aimed to prospectively assess potential changes in baseline LAV, left ventricular ejection fraction (LVEF), NT-proBNP-level and the covered distance in the 6-min walk-test 6 weeks and 6 months after LAA closure with the WATCHMAN™ device. Read More

    Stroke Prevention Rehabilitation Intervention Trial of Exercise (SPRITE) - a randomised feasibility study.
    BMC Cardiovasc Disord 2017 Dec 12;17(1):290. Epub 2017 Dec 12.
    Department of General Practice and Primary Care, Queen's University, Belfast, UK.
    Background: The value of cardiac rehabilitation (CR) after a transient ischaemic attack (TIA) or minor stroke is untested despite these conditions sharing similar pathology and risk factors to coronary heart disease. We aimed to evaluate the feasibility of conducting a trial of an adapted home-based CR programme, 'The Healthy Brain Rehabilitation Manual', for patients following a TIA/minor stroke, participants' views on the intervention and, to identify the behaviour change techniques (BCTs) used.

    Methods: Clinicians were asked to identify patients attending the Ulster Hospital, Belfast within 4 weeks of a first TIA or minor stroke. Read More

    Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation.
    BMC Cardiovasc Disord 2017 Dec 8;17(1):289. Epub 2017 Dec 8.
    Arrhythmia Clinic, Skåne University Hospital and Department of Cardiology, Clinical Sciences, Lund University, 21185, Lund, Sweden.
    Background: Atrial fibrillatory cycle length has been considered one of the indices of atrial electrical remodelling during atrial fibrillation (AF), which can be assessed from surface ECG by computer-assisted calculation of atrial fibrillatory rate (AFR). Horses have been suggested as a bona fide model for AF studies since horses too, develop lone AF, however data on AF characteristics in horses are extremely sparse and non-invasive characterization of AF complexity using surface ECG processing has not been reported.

    Aim: The aim was to study characteristics of induced AF and its modification by flecainide. Read More

    Orthogonal P-wave morphology is affected by intra-atrial pressures.
    BMC Cardiovasc Disord 2017 Dec 6;17(1):288. Epub 2017 Dec 6.
    Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
    Background: It has previously been shown that the morphology of the P-wave neither depends on atrial size in healthy subjects with physiologically enlarged atria nor on the physiological anatomical variation in transverse orientation of the left atrium. The present study aimed to investigate if different pressures in the left and right atrium are associated with different P-wave morphologies.

    Methods: 38 patients with isolated, increased left atrial pressure, 51 patients with isolated, increased right atrial pressure and 76 patients with biatrially increased pressure were studied. Read More

    Association of 24 h-systolic blood pressure variability and cardiovascular disease in patients with obstructive sleep apnea.
    BMC Cardiovasc Disord 2017 Dec 6;17(1):287. Epub 2017 Dec 6.
    Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road 2, Guangzhou, 510080, China.
    Background: To evaluate association of 24 h-systolic blood pressure (SBP) variability and obstructive sleep apnea (OSA) as defined by the apnea-hypopnea index ≥5/h; and association of 24 h-SBP variability and prevalent cardiovascular disease (CVD) in OSA patients.

    Methods: Participants underwent polysomongraphy to evaluate the presence of OSA, and 24 h-ambulatory blood pressure monitoring was applied to evaluate 24 h-SBP variability as indexed by weighted 24 h-standard deviation (SD) of SBP. Between-group differences were evaluated in participants with and without OSA. Read More

    Auxiliary diagnostic potential of ventricle geometry and late gadolinium enhancement in left ventricular non-compaction; non-randomized case control study.
    BMC Cardiovasc Disord 2017 Dec 6;17(1):286. Epub 2017 Dec 6.
    Department of Internal medicine, Faculty of Medicine, "J.J. Strossmayer" University of Osijek, Osijek, Croatia.
    Background: There are still ambiguities existing in regard to left ventricular non-compaction (LVNC) diagnostic imaging. The aim of our study was to analyze diagnostic potential of late gadolinium enhancement (LGE) and ventricle geometry in patients with LVNC and controls.

    Methods: Data on cardiac magnetic resonance imaging (CMR) studies for LVNC were reassessed from the hospital's database (3. Read More

    Assessment of tetralogy of Fallot-associated congenital extracardiac vascular anomalies in pediatric patients using low-dose dual-source computed tomography.
    BMC Cardiovasc Disord 2017 Dec 4;17(1):285. Epub 2017 Dec 4.
    Department of Radiology, West China Second University Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, Sichuan, 610041, China.
    Background: To investigate the diagnostic value of dual-source computed tomography (DSCT) in the evaluation of tetralogy of Fallot (TOF)-associated extracardiac vascular abnormalities in pediatric patients compared with transthoracic echocardiography (TTE).

    Methods: One hundred and twenty-three pediatric patients diagnosed with TOF were included in this retrospective study. All patients underwent DSCT and TTE preoperatively. Read More

    Double product reflects the association of heart rate with MACEs in acute coronary syndrome patients treated with percutaneous coronary intervention.
    BMC Cardiovasc Disord 2017 Dec 2;17(1):284. Epub 2017 Dec 2.
    Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Changping Road NO.57, Shantou, Guangdong, 515041, China.
    Background: There is little information about the prognostic value of double product (DP) for acute coronary syndrome (ACS) patients treated with percutaneous coronary intervention (PCI). The aim of this study was to investigate whether DP reflects the predictive power of heart rate (HR) or systolic blood pressure (SBP) in ACS patients treated with PCI.

    Methods: A total of 7590 ACS patients who had undergone PCI, free from cardiac shock, were included. Read More

    Unloading shoes for intermittent claudication: a randomised crossover trial.
    BMC Cardiovasc Disord 2017 Nov 28;17(1):283. Epub 2017 Nov 28.
    General Surgery Department, York Hospital, Wigginton Road, York, YO31 8HE, UK.
    Background: The purpose of this study was to assess the functional effects and acceptability of rocker-soled shoes that were designed to relatively "unload" the calf muscles during walking in people with calf claudication due to peripheral arterial disease.

    Methods: In this randomised AB/BA crossover trial, participants completed two assessment visits up to two weeks apart. At each visit, participants completed walking tests whilst wearing the unloading shoes or visually-similar control shoes. Read More

    A prospective study examining the role of myocardial Fibrosis in outcome following mitral valve repair IN DEgenerative mitral Regurgitation: rationale and design of the mitral FINDER study.
    BMC Cardiovasc Disord 2017 Nov 22;17(1):282. Epub 2017 Nov 22.
    University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.
    Background: The optimal management of chronic severe primary degenerative mitral regurgitation (MR) is to repair the valve but identification of the optimal timing of surgery remains challenging. Current guidelines suggest 'watchful waiting' until the onset of symptoms or left ventricular (LV) dysfunction but these have been challenged as promoting 'rescue surgery'. Better predictors are required to inform decision-making in relation to the necessity and timing of surgery. Read More

    Long-term prognosis of patients with non-ST-segment elevation myocardial infarction according to coronary arteries atherosclerosis extent on coronary angiography: a historical cohort study.
    BMC Cardiovasc Disord 2017 Nov 16;17(1):279. Epub 2017 Nov 16.
    Department of Health, Science and Technology, Aalborg University, Aalborg, Denmark.
    Background: Patients with non-ST-segment elevation myocardial infarction (NSTEMI) without obstructive coronary artery disease (CAD) are often managed differently than those with obstructive CAD, therefore we aimed in this study to examine the long-term prognosis of patients with NSTEMI according to the degree of CAD on coronary angiography (CAG).

    Methods: We examined 8.889 consecutive patients admitted for first time NSTEMI during 2000-2011, to whom CAG was performed. Read More

    Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus.
    BMC Cardiovasc Disord 2017 Nov 16;17(1):280. Epub 2017 Nov 16.
    Department of Cardiovascular Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
    Background: Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus.

    Methods: This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Read More

    Successful percutaneous coronary intervention for an in-stent chronic total occlusion in a patient with dextrocardia: a case report.
    BMC Cardiovasc Disord 2017 11 16;17(1):281. Epub 2017 Nov 16.
    Center for Cardiology - Cardiology I, University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.
    Background: Percutaneous coronary interventions of chronic total occlusion represent one of the most challenging issues in interventional cardiology. A Caucasian patient with dextrocardia presented with an in-stent chronic total occluded right coronary artery, a constellation which has not been described previously in the literature.

    Case Presentation: A 69-year-old man with pre-known situs inversus totalis and a long history of coronary artery disease with multiple interventions and stent-implantations presented to our department suffering from episodes of chest pain under exercise. Read More

    Effects of angiotensin receptor blockers on neointimal characteristics in angina patients requiring stent implantation: optical coherence tomography analysis.
    BMC Cardiovasc Disord 2017 Nov 15;17(1):278. Epub 2017 Nov 15.
    Department of Cardiology, Korea University Anam Hospital, Inchon-ro 73, Seongbuk-gu, Seoul, South Korea.
    Background: Angiotensin receptor blockers (ARBs) are known for its anti-inflammatory and anti-proliferative effects. The aim of the study was to evaluate long-term effects of ARBs on morphologic characteristics of stent restenosis in patients with coronary artery disease requiring stent implantation by optical coherence tomography (OCT).

    Methods: Patients with coronary artery disease having history of drug-eluting stent implantation (n = 407) were analyzed on the basis of ARB therapy as the ARB group (n = 162) and the non-ARB group (n = 245). Read More

    Case report: electrical storm during induced hypothermia in a patient with early repolarization.
    BMC Cardiovasc Disord 2017 Nov 15;17(1):277. Epub 2017 Nov 15.
    Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland.
    Background: Population based studies showed an association of early repolarization in the electrocardiogram (ECG) and a higher rate of sudden cardiac death presumably due to ventricular fibrillation. The triggers for ventricular fibrillation in patients with early repolarization are not fully understood.

    Case Presentation: We describe the case of a young patient with a survived ventricular fibrillation arrest while asleep followed by multiple episodes of recurrent ventricular fibrillation. Read More

    Control of cardiovascular risk factors and its determinants in the general population- findings from the STAAB cohort study.
    BMC Cardiovasc Disord 2017 Nov 2;17(1):276. Epub 2017 Nov 2.
    Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
    Background: While data from primary care suggest an insufficient control of vascular risk factors, little is known about vascular risk factor control in the general population. We therefore aimed to investigate the adoption of adequate risk factor control and its determinants in the general population free of cardiovascular disease (CVD).

    Methods: Data from the Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB) Cohort Study, a population-based study of inhabitants aged 30 to 79 years from the general population of Würzburg (Germany), were used. Read More

    Predicting operative mortality in octogenarians for isolated coronary artery bypass grafting surgery: a retrospective study.
    BMC Cardiovasc Disord 2017 Nov 2;17(1):275. Epub 2017 Nov 2.
    Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
    Background: Available cardiac surgery risk scores have not been validated in octogenarians. Our objective was to compare the predictive ability of the Society of Thoracic Surgeons (STS) score, EuroSCORE I, and EuroSCORE II in elderly patients undergoing isolated coronary artery bypass grafting surgery (CABG).

    Methods: All patients who underwent isolated CABG (2002 - 2008) were identified from the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) registry. Read More

    Vitamin D3 repletion versus placebo as adjunctive treatment of heart failure patient quality of life and hormonal indices: a randomized, double-blind, placebo-controlled trial.
    BMC Cardiovasc Disord 2017 Oct 30;17(1):274. Epub 2017 Oct 30.
    Providence Saint Patrick Hospital, 500 W. Broadway St, Missoula, MT, 59802, USA.
    Background: Vitamin D status may influence heart failure (HF) patient outcomes by affecting b-type natriuretic peptide (BNP), parathyroid hormone (PTH), and enhancing cardiac contractility. Vitamin D deficiency is associated with morbidity and mortality in HF patients. The objective of this study was to determine if vitamin D3 at a comparatively high dose would replete 25-hydroxyvitamin D (25(OH)D) stores, improve BNP, PTH, cardiopulmonary function, reduce inflammatory markers, and improve quality of life (QOL) in HF patients. Read More

    Fluid upstream shear stress of rabbit aortic stenosis inhibits neointimal hyperplasia by promoting endothelization after balloon injury.
    BMC Cardiovasc Disord 2017 Oct 30;17(1):273. Epub 2017 Oct 30.
    Department of Cardiology, Jiangmen Central Hospital, No.23, Haibang Street, Jiangmen, Guangdong, 529030, China.
    Background: Atherosclerosis is associated with disturbed blood flow characterized by low and oscillatory shear stress (SS), however, few study directly links SS to neointimal hyperplasia in animal model. This study was focused on the effects of changed SS upon the neointimal hyperplasia which responded to balloon injury in a novel rabbit model with partially-constricted abdominal aorta.

    Methods: We established a rabbit model subjected to partial abdominal aortic constriction with a cylinder-shaped cannula as a model of disturbed flow, which was similar to the hemodynamic features of stenosis caused by atherosclerosis plaque. Read More

    The protective effect of activating Nrf2 / HO-1 signaling pathway on cardiomyocyte apoptosis after coronary microembolization in rats.
    BMC Cardiovasc Disord 2017 Oct 24;17(1):272. Epub 2017 Oct 24.
    Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China.
    Background: Myocardial apoptosis is closely related to myocardial injury caused by coronary microembolization (CME).Nuclear factor erythroid 2-like (Nrf2) has been taken into account as an inhibitor of apoptosis in various tissues. Thus, this research aims to investigate which part Nrf2/HO-1 signaling pathway plays in myocardial apoptosis process following the effect of CME on rats. Read More

    Ideal cardiovascular health and the subclinical impairments of cardiovascular diseases: a cross-sectional study in central south China.
    BMC Cardiovasc Disord 2017 Oct 18;17(1):269. Epub 2017 Oct 18.
    Department of Health Management Centre, the Third Xiangya Hospital, Central South University, Tongzipo Road 138, Changsha, Hunan Province, 410013, China.
    Background: Ideal cardiovascular health (CVH) is related to a low cardiovascular disease risk profile. This study aimed to investigate CVH metrics with both the biomarkers and markers of subclinical impairments of cardiovascular diseases (CVDs) in subjects from central south China.

    Methods: The ideal CVH score (non-smoking status; ideal body mass index; regular physical activity; healthy diet; and an optimal serum cholesterol, blood pressure, and glucose profile; 1 point for each; total score: 0-7) was collected from 3009 participants without a history of CVDs. Read More

    Comparison of circulating dendritic cell and monocyte subsets at different stages of atherosclerosis: insights from optical coherence tomography.
    BMC Cardiovasc Disord 2017 Oct 18;17(1):270. Epub 2017 Oct 18.
    Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
    Background: While specific patterns of circulating dendritic cells (DCs) and monocytes are associated with the incidence of coronary artery disease, the characterization of circulating DC and monocyte subsets in patients with different stages of atherosclerosis remains unclear.

    Methods: Forty-eight patients with unstable angina pectoris (UAP) diagnosed by angiography were enrolled. Likewise, 31 patients with ST-segment elevation myocardial infarction (STEMI) were enrolled and confirmed with the presence of thrombosis by angiography. Read More

    Deletion of the NR4A nuclear receptor NOR1 in hematopoietic stem cells reduces inflammation but not abdominal aortic aneurysm formation.
    BMC Cardiovasc Disord 2017 Oct 18;17(1):271. Epub 2017 Oct 18.
    Department of Medicine, Division of Cardiology, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, UPMC and University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
    Background: The NR4A3 orphan nuclear hormone receptor, NOR1, functions as a constitutively active transcription factor to regulate inflammation, proliferation, and cell survival during pathological vascular remodeling. Inflammatory processes represent key mechanisms leading to abdominal aortic aneurysm (AAA) formation. However, a role of NOR1 in AAA formation has not been investigated previously. Read More

    Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia.
    BMC Cardiovasc Disord 2017 Oct 17;17(1):267. Epub 2017 Oct 17.
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
    Background: Tachyarrhythmia (TA) and bradyarrhythmia (BA) are cardiac rhythm disorders that result in the decline of quality of life. While patients with periodontitis are at a high risk of cardiovascular disease (CVD), little causal information between TA and BA has been provided to date. To assess the relationship, periodontal bacterial infection in patients with TA or BA was evaluated. Read More

    Quality of life questionnaire predicts poor exercise capacity only in HFpEF and not in HFrEF.
    BMC Cardiovasc Disord 2017 Oct 17;17(1):268. Epub 2017 Oct 17.
    Clinic of Cardiology, University Clinical Centre of Kosova, Rrethi i Spitalit, P.N, 10000, Prishtina, Kosovo.
    Background: The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is the most widely used measure of quality of life (QoL) in HF patients. This prospective study aimed to assess the relationship between QoL and exercise capacity in HF patients.

    Methods: The study subjects were 118 consecutive patients with chronic HF (62 ± 10 years, 57 females, in NYHA I-III). Read More

    Takotsubo cardiomyopathy in a patient with ileus: a case report.
    BMC Cardiovasc Disord 2017 Oct 17;17(1):266. Epub 2017 Oct 17.
    Department of Surgery, Madou Sin-Lau Hospital, 20 Lingzilin, Tainan, 72152, Taiwan.
    Background: Takotsubo cardiomyopathy (TCM) is a form of stress-induced cardiomyopathy featured by the dilatation of the apex of the left ventricle during systole. Whereas the pathogenesis of this disorder is not well understood, it usually occurs after an emotional or physical stress such as acute asthma, surgery, chemotherapy, and stroke. However, its occurrence in ileus patients is rarely reported. Read More

    Left ventricular non-compaction cardiomyopathy with coronary artery anomaly complicated by ventricular tachycardia.
    BMC Cardiovasc Disord 2017 Oct 16;17(1):263. Epub 2017 Oct 16.
    Centre for Research and Development, Uppsala University/Region Gävleborg, SE-801 87, Gävle, Sweden.
    Background: Non-compaction cardiomyopathy (NCCM) is characterized by prominent trabeculations, deep intertrabecular recesses, and a thick non-compacted endocardial myocardium. Prevalence in the general population remains unclear, but echocardiography series report 0.05%. Read More

    Diagnostic performance of various familial hypercholesterolaemia diagnostic criteria compared to Dutch lipid clinic criteria in an Asian population.
    BMC Cardiovasc Disord 2017 Oct 16;17(1):264. Epub 2017 Oct 16.
    Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), University Teknologi MARA, 47000, Sungai Buloh, Selangor, Malaysia.
    Background: Familial hypercholesterolaemia (FH) is a genetic disorder with a high risk of developing premature coronary artery disease that should be diagnosed as early as possible. Several clinical diagnostic criteria for FH are available, with the Dutch Lipid Clinic Criteria (DLCC) being widely used. Information regarding diagnostic performances of the other criteria against the DLCC is scarce. Read More

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