9,751 results match your criteria BMC Cancer[Journal]


Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.

BMC Cancer 2019 04 18;19(1):366. Epub 2019 Apr 18.

Universitätsklinikum Schleswig-Holstein, Schittenhelmstr, 7, D-24 105, Kiel, Germany.

Following publication of the original article [1], it was reported that the legend for Fig. 1 was incomplete. The complete figure legend is. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5568-6DOI Listing
April 2019
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Imaging biomarkers for well and moderate hepatocellular carcinoma: preoperative magnetic resonance image and histopathological correlation.

BMC Cancer 2019 Apr 18;19(1):364. Epub 2019 Apr 18.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China.

Background: Our aim of the study is to investigate the feasibility of preoperative prediction for hepatocellular carcinoma (HCC) histological grading using gadoxetic acid-enhanced magnetic resonance imaging (MRI).

Methods: This study included one hundred and fifty-six patients with solitary HCC. Preoperative gadoxetic acid-enhanced MRI findings were retrospectively analyzed. Read More

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http://dx.doi.org/10.1186/s12885-019-5574-8DOI Listing

Differential proteomic comparison of breast cancer secretome using a quantitative paired analysis workflow.

BMC Cancer 2019 Apr 18;19(1):365. Epub 2019 Apr 18.

Laboratory of Toxinology, Oswaldo Cruz Institute, Fiocruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro, 21040-360, Brazil.

Background: Worldwide, breast cancer is the main cause of cancer mortality in women. Most cases originate in mammary ductal cells that produce the nipple aspirate fluid (NAF). In cancer patients, this secretome contains proteins associated with the tumor microenvironment. Read More

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http://dx.doi.org/10.1186/s12885-019-5547-yDOI Listing

Differential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma.

BMC Cancer 2019 Apr 16;19(1):360. Epub 2019 Apr 16.

Department of Urology, West China Hospital, Sichuan University, Chengdu, People's Republic of China, 610041.

Background: In clinical practice, the detection of biomarkers is mostly based on primary tumors for its convenience in acquisition. However, immune checkpoints may express differently between primary and metastatic tumor. Therefore, we aimed to compare the differential expressions of PD-1, PD-L1 and PD-L2 between the primary and metastatic sites of renal cell carcinoma (RCC). Read More

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http://dx.doi.org/10.1186/s12885-019-5578-4DOI Listing
April 2019
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Micafungin prophylaxis for acute leukemia patients undergoing induction chemotherapy.

BMC Cancer 2019 Apr 16;19(1):358. Epub 2019 Apr 16.

Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Background: Micafungin is a well-tolerated and effective prophylactic antifungal agent used in hematologic diseases. In this prospective trial, we evaluated the efficacy and safety of prophylactic micafungin during first induction chemotherapy in patients with acute leukemia. We also compared outcomes of prophylactic micafungin with those of prophylactic posaconazole in acute myeloid leukemia (AML). Read More

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http://dx.doi.org/10.1186/s12885-019-5557-9DOI Listing
April 2019
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Health-related quality of life as an endpoint in oncology phase I trials: a systematic review.

BMC Cancer 2019 Apr 16;19(1):361. Epub 2019 Apr 16.

Methodology and Quality of Life in Oncology Unit, INSERM UMR 1098, University Hospital of Besançon, Besançon, France.

Background: Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of this study is to review the phase I in oncology which used HRQoL as endpoint. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5579-3DOI Listing
April 2019
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Genome sequencing analysis of blood cells identifies germline haplotypes strongly associated with drug resistance in osteosarcoma patients.

BMC Cancer 2019 Apr 16;19(1):357. Epub 2019 Apr 16.

Inova Children's Hospital, Falls Church, VA, USA.

Background: Osteosarcoma is the most common malignant bone tumor in children. Survival remains poor among histologically poor responders, and there is a need to identify them at diagnosis to avoid delivering ineffective therapy. Genetic variation contributes to a wide range of response and toxicity related to chemotherapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5474-yDOI Listing
April 2019
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Brain metastases in patients with neuroendocrine neoplasms: risk factors and outcome.

BMC Cancer 2019 Apr 16;19(1):362. Epub 2019 Apr 16.

Department of Gastroenterology and Endocrinology, University Hospital Marburg, Baldinger Strasse, 35043, Marburg, Germany.

Background: Brain metastases (BM) are rarely reported in patients with neuroendocrine carcinoma (NEC) of non-lung origin and neuroendocrine tumors (NET) of the gastroenteropancreatic (GEP) or bronchopulmonary system. However, symptomatic brain metastases are associated with dismal prognosis, so early detection and treatment could be advisable.

Methods: We retrospectively analyzed 51 patients with GEP-NEN and bronchopulmonary NEN excluding small cell lung cancer. Read More

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http://dx.doi.org/10.1186/s12885-019-5559-7DOI Listing
April 2019
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Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation.

Authors:
Duan Chu Lai Wei

BMC Cancer 2019 Apr 16;19(1):359. Epub 2019 Apr 16.

College of Life Sciences, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing, China.

Background: Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to be functionally silent and evolutionarily neutral. Read More

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http://dx.doi.org/10.1186/s12885-019-5572-xDOI Listing

Feasibility of dynamic risk assessment for patients with repeated trans-arterial chemoembolization for hepatocellular carcinoma.

BMC Cancer 2019 Apr 16;19(1):363. Epub 2019 Apr 16.

Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.

Background: Hepatoma arterial-embolization prognostic (HAP) score and its modifications (modified HAP [mHAP] and mHAP-II), consisting of some or all of the following factors of tumor size, number, alpha-fetoprotein, bilirubin, and serum albumin, have been found to predict outcomes after trans-arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). We investigated the feasibility of using HAP-related risk scores for dynamic risk assessment during repeated TACE.

Methods: A total of 619 HCC patients treated with TACE from two institutions between 2003 and 2010 were included. Read More

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http://dx.doi.org/10.1186/s12885-019-5495-6DOI Listing

Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells.

BMC Cancer 2019 Apr 15;19(1):356. Epub 2019 Apr 15.

Departamento de Medicina Genomica y Toxicologia Ambiental, Instituto de Investigaciones Biomedicas (IIBO), Universidad Nacional Autonoma de Mexico (UNAM), 04510 Ciudad de Mexico (CDMX), Mexico, Mexico.

Background: Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been well characterized in MCF7 luminal A breast cancer cells. The GR activates a variety of protective mechanisms, such as inhibitors of apoptosis proteins (IAPs). Read More

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http://dx.doi.org/10.1186/s12885-019-5563-yDOI Listing
April 2019
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Depletion of PCAT-1 in head and neck cancer cells inhibits tumor growth and induces apoptosis by modulating c-Myc-AKT1-p38 MAPK signalling pathways.

BMC Cancer 2019 Apr 15;19(1):354. Epub 2019 Apr 15.

Department of Pathology, Saint Louis University, 1100 South Grand Boulevard, St. Louis, MO, 63104, USA.

Background: Head and neck squamous cell carcinoma (HNSCC) represents one of the most common malignancies worldwide with a high mortality rate mainly due to lack of early detection markers, frequent association with metastasis and aggressive phenotype. Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancers. The lncRNA prostate cancer-associated transcript 1 (PCAT-1) showed potential oncogenic roles in different cancers, however its role in HNSCC is not known. Read More

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http://dx.doi.org/10.1186/s12885-019-5562-zDOI Listing
April 2019
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Bilateral mantle cell lymphoma of the ciliary body that responded to a combined local radiotherapy and chemotherapy regimen: a case report.

BMC Cancer 2019 Apr 15;19(1):355. Epub 2019 Apr 15.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) that often affects men over the age of 60. Systemic metastasis of MCL to eyes is rare and intraocular involvement is even rarer, which usually affects the choroid and iris. To the best of our knowledge, ciliary body metastasis of systemic MCL has not been reported. Read More

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http://dx.doi.org/10.1186/s12885-019-5530-7DOI Listing
April 2019
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Relative efficacy of interventions in the treatment of second-line non-small cell lung cancer: a systematic review and network meta-analysis.

BMC Cancer 2019 Apr 15;19(1):353. Epub 2019 Apr 15.

Ohio State University Medical Center, Columbus, OH, USA.

Background: Locally advanced or metastatic non-small cell lung cancer (NSCLC) that has progressed after first-line treatment has a poor prognosis. Recent randomized clinical trials (RCTs) have demonstrated survival benefits of alternative treatments to docetaxel. However, information is lacking on which patients benefit the most and what drug or regimen is optimal. Read More

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http://dx.doi.org/10.1186/s12885-019-5569-5DOI Listing
April 2019
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Salivary gland carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology.

BMC Cancer 2019 Apr 11;19(1):350. Epub 2019 Apr 11.

Department of Oral & Maxillofacial - Head & Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.

Background: Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor salivary glands with oral cancer instead of with salivary gland carcinoma as a whole, because of the international disease coding. Read More

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http://dx.doi.org/10.1186/s12885-019-5564-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458649PMC
April 2019
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Functional role of SGK3 in PI3K/Pten driven liver tumor development.

BMC Cancer 2019 Apr 11;19(1):343. Epub 2019 Apr 11.

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, UCSF, 513 Parnassus Ave, San Francisco, CA, 94143, USA.

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of PI3K catalytic subunit alpha (PIK3CA) and/or loss of Pten often occur in human HCCs. Read More

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http://dx.doi.org/10.1186/s12885-019-5551-2DOI Listing

An unusual complication of sacral nerve root injury following bone marrow harvesting: a case report.

BMC Cancer 2019 Apr 11;19(1):347. Epub 2019 Apr 11.

Department of Rehabilitation Medicine, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea.

Background: Hematopoietic stem cell transplantation (HSCT) remains an important therapeutic option for many hematologic malignancies. Bone marrow harvesting from an appropriate donor must be conducted for hematopoietic stem cell transplantation (HSCT). Many previous studies show complications of the recipient after hematopoietic stem cell transplantation (HSCT). Read More

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http://dx.doi.org/10.1186/s12885-019-5567-7DOI Listing
April 2019
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Is exposure to tobacco associated with extrahepatic cholangiocarcinoma epidemics? A retrospective proportional mortality study in China.

BMC Cancer 2019 Apr 11;19(1):348. Epub 2019 Apr 11.

Cancer Institute & Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, China.

Background: Extrahepatic cholangiocarcinoma (ECC) has become one of the most rapidly increasing malignancies in China during recent decades. The relationship between tobacco exposure and ECC epidemics is unclear; this study aimed to explore this relationship.

Methods: We included 55,806 participants aged 30 years or older from the National Mortality and Smoking Survey of China. Read More

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http://dx.doi.org/10.1186/s12885-019-5484-9DOI Listing
April 2019
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A web-based psycho-educational intervention (Fex-Can) targeting sexual dysfunction and fertility-related distress in young adults with cancer: study protocol of a randomized controlled trial.

BMC Cancer 2019 Apr 11;19(1):344. Epub 2019 Apr 11.

Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.

Background: This study protocol describes the clinical trial of the Fex-Can intervention, a web-based self-help program targeting sexual dysfunction and fertility-related distress. The psycho-educational intervention has been developed in collaboration with young patients with cancer and shown to be feasible. The primary objective is to determine whether the Fex-Can intervention, provided in addition to standard care, is superior to standard care in terms of reduction of sexual dysfunction and fertility-related distress directly after end of the 12-week program. Read More

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http://dx.doi.org/10.1186/s12885-019-5518-3DOI Listing

Clinical application of ultrasound-guided percutaneous microwave ablation for benign breast lesions: a prospective study.

BMC Cancer 2019 Apr 11;19(1):345. Epub 2019 Apr 11.

Department of Ultrasound, Beijing Tian Tan Hospital, Capital Medical University, No. 119, West Road of South 4th Ring Road, Fengtai District, Beijing, 100160, China.

Background: Background: Benign breast lesions are the most common diseases in adult women, which have been treated with minimally invasive therapies in recent years. Little is known about the feasibility of Microwave ablation (MWA) for benign breast lesion treatment. The primary aim of this prospective study was to evaluate the safety and efficiency of MWA as a potential therapeutic option for benign breast lesions in a single-center cohort study. Read More

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http://dx.doi.org/10.1186/s12885-019-5523-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458746PMC
April 2019
1 Read
3.362 Impact Factor

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4.

BMC Cancer 2019 Apr 11;19(1):351. Epub 2019 Apr 11.

School of Pharmacy, Queen's University Belfast, Belfast, UK.

Background: Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more aggressive tumours with enhanced metastatic ability. Read More

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http://dx.doi.org/10.1186/s12885-019-5500-0DOI Listing

Whole genome sequencing reveals complexity in both HPV sequences present and HPV integrations in HPV-positive oropharyngeal squamous cell carcinomas.

BMC Cancer 2019 Apr 11;19(1):352. Epub 2019 Apr 11.

Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.

Background: High risk human papillomaviruses (HPV) plays important roles in the development of cervical cancer, a number of other anogenital cancer and they are increasingly found in oropharyngeal squamous cell carcinoma (OPSCC), however there has not been comprehensive analysis about the role how these viruses play in the development of OPSCC.

Methods: To characterize the physical status of HPV within OPSCC and to determine the effect this has throughout the host genome, we have performed 30-40X whole genome sequencing (WGS) on the BGI sequencing platform on 34 OPSCCs: 28 of which were HPV positive. We then examined the sequencing data to characterize the HPV copy number and HPV physical status to determine what effect they have on both HPV and human genome structural changes. Read More

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http://dx.doi.org/10.1186/s12885-019-5536-1DOI Listing
April 2019
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Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion.

BMC Cancer 2019 Apr 11;19(1):346. Epub 2019 Apr 11.

School of Biological Sciences, National Institute of Science Education and Research Bhubaneswar, HBNI, PO: Bhimpur-Padanpur, Via: Jatni, Odisha, 752050, India.

Background: Prostate cancer is the most common form of cancer in males and accounts for high cancer related deaths. Therapeutic advancement in prostate cancer has not been able to reduce the mortality burden of prostate cancer, which warrants further research. FRG1 which affects angiogenesis and cell migration in Xenopus, can be a potential player in tumorigenesis. Read More

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http://dx.doi.org/10.1186/s12885-019-5509-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458714PMC

A leucine-rich diet modulates the mTOR cell signalling pathway in the gastrocnemius muscle under different Walker-256 tumour growth conditions.

BMC Cancer 2019 Apr 11;19(1):349. Epub 2019 Apr 11.

Department of Structural and Functional Biology, Institute of Biology, University of Campinas, UNICAMP, CP 6109, 13083862, Campinas, São Paulo, Brazil.

Background: The exact signalling mechanism of the mTOR complex remains a subject of constant debate, even with some evidence that amino acids participate in the same pathway as used for insulin signalling during protein synthesis. Therefore, this work conducted further study of the actions of amino acids, especially leucine, in vivo, in an experimental model of cachexia. We analysed the effects of a leucine-rich diet on the signalling pathway of protein synthesis in muscle during a tumour growth time-course. Read More

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http://dx.doi.org/10.1186/s12885-019-5448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458732PMC

Enzalutamide versus flutamide for castration-resistant prostate cancer after combined androgen blockade therapy with bicalutamide: study protocol for a multicenter randomized phase II trial (the OCUU-CRPC study).

BMC Cancer 2019 Apr 11;19(1):339. Epub 2019 Apr 11.

Department of Urology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Enzalutamide is an oral androgen receptor targeted agent that has been shown to improve survival in PREVAIL trials and has been approved for patients with chemo-naïve metastatic castration-resistant prostate cancer (CRPC). Meanwhile, flutamide is a non-steroidal oral anti-androgen that was commonly used before the approval of bicalutamide. The objective of the OCUU-CRPC study is to compare the efficacy and safety between second-line hormonal therapy of enzalutamide and flutamide as alternative anti-androgen therapy (AAT) after combined androgen blockade (CAB) therapy that included bicalutamide in patients with CRPC. Read More

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http://dx.doi.org/10.1186/s12885-019-5526-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458677PMC
April 2019
1 Read

Outcomes of non-high grade serous carcinoma after neoadjuvant chemotherapy for advanced-stage ovarian cancer: a Korean gynecologic oncology group study (OV 1708).

BMC Cancer 2019 Apr 11;19(1):341. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, South Korea.

Background: Outcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-HGSC. This study aimed to evaluate the outcomes of NAC in non-HGSC patients with advanced-stage ovarian cancer.

Methods: We conducted a retrospective cohort study of patients who underwent NAC for advanced stage non-HGSC between 2002 and 2017 in 17 institutions. Read More

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http://dx.doi.org/10.1186/s12885-019-5514-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458623PMC
April 2019
1 Read

Rationale and design of extended cancer education for longer term survivors (EXCELS): a randomized control trial of 'high touch' vs. 'high tech' cancer survivorship self-management tools in primary care.

BMC Cancer 2019 Apr 11;19(1):340. Epub 2019 Apr 11.

Rutgers Biomedical and Health Sciences, Rutgers, the State University of New Jersey, 112 Paterson Street, Room 446, New Brunswick, NJ, 08901, USA.

Background: Breast, colorectal, and prostate cancer survivors are at increased risk for late and long-term effects post-treatment. The post-treatment phase of care is often poorly coordinated and survivors navigate follow-up care with minimal information or guidance from their healthcare team. This manuscript describes the Extended Cancer Education for Longer-term Survivors (EXCELS) in Primary Care protocol. Read More

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http://dx.doi.org/10.1186/s12885-019-5531-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458696PMC

Prognostic value of lymphocyte-monocyte ratio at diagnosis in Hodgkin lymphoma: a meta-analysis.

BMC Cancer 2019 Apr 11;19(1):338. Epub 2019 Apr 11.

Health Economics Unit, Department of Clinical Science (Malmö), Lund University, Lund, Sweden.

Background: Prognoses of most adult Hodgkin lymphoma (HL) patients are excellent; most of them can achieve permanent remission that can be considered cured. However, many are under-treated or over-treated by standard modern therapies. An accurate determination of prognosis may allow clinicians to design personalised treatment according to individual risk of disease progression and survival. Read More

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http://dx.doi.org/10.1186/s12885-019-5552-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458704PMC
April 2019
2 Reads

How do breast cancer surgery scars impact survivorship? Findings from a nationwide survey in the United States.

BMC Cancer 2019 Apr 11;19(1):342. Epub 2019 Apr 11.

Mercury Medical Research & Writing, New York, NY, USA.

Background: The surgical treatment of breast cancer has been associated with negative consequences for patients' body image, sexual functioning, mental health, and social adjustment. Recent advances in the surgical approach to breast cancer allow the oncologic surgeon to safely optimize cosmetic outcomes. Little is known about the possible relevance of surgical scars. Read More

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http://dx.doi.org/10.1186/s12885-019-5553-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458748PMC

Health literacy and patient participation in multidisciplinary tumor conferences in breast cancer care: a multilevel modeling approach.

BMC Cancer 2019 Apr 8;19(1):330. Epub 2019 Apr 8.

Center for Health Communication and Health Services Research (CHSR), Department of Psychosomatic Medicine and Psychotherapy, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.

Background: Decisions made in multidisciplinary tumor conferences (MTC) that consider patient preferences result in better patient outcomes. Furthermore, it has been shown that in some breast cancer centers in Germany, patients participate in MTCs and that participation is associated with sociodemographic and breast cancer center-related factors. Health literacy (HL) has been shown to be predictive for individual health behavior and is an important prerequisite for patient participation in healthcare. Read More

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http://dx.doi.org/10.1186/s12885-019-5546-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454712PMC
April 2019
1 Read

Androgen receptor mRNA expression is a predictor for recurrence-free survival in non-muscle invasive bladder cancer.

BMC Cancer 2019 Apr 8;19(1):331. Epub 2019 Apr 8.

Department of Urology and Renal Transplantation, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, 232-0024, Japan.

Background: Non-muscular invasive bladder cancer (NMIBC) has a high risk of recurrence. As androgen receptor (AR) reportedly affects bladder cancer, we assessed the correlation between NMIBC recurrence and tumor AR expression in Japanese patients.

Methods: We retrospectively reviewed 53 specimens of non-metastatic NMIBC, with recurrence-free survival (RFS) as the primary endpoint. Read More

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http://dx.doi.org/10.1186/s12885-019-5512-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454612PMC
April 2019
1 Read

Diagnostic accuracy of N-ammonia PET, C-methionine PET and F-fluorodeoxyglucose PET: a comparative study in patients with suspected cerebral glioma.

BMC Cancer 2019 Apr 8;19(1):332. Epub 2019 Apr 8.

Department of Nuclear Medicine, the First Affiliated Hospital of Sun Yat-sen University, 58# Zhongshan Er Road, Guangzhou, Guangdong Province, 510080, People's Republic of China.

Background: The treatment of patients with glioma depended on the nature of the lesion and on histological grade of the tumor. Positron emission tomography (PET) using N-ammonia (NH), C-methionine (MET) and F-fluorodeoxyglucose (FDG) have been used to assess brain tumors. Our aim was to compare their diagnostic accuracies in patients with suspected cerebral glioma. Read More

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http://dx.doi.org/10.1186/s12885-019-5560-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454631PMC

Risk factors affecting prognosis in metachronous liver metastases from WHO classification G1 and G2 gastroenteropancreatic neuroendocrine tumors after initial R0 surgical resection.

BMC Cancer 2019 Apr 8;19(1):335. Epub 2019 Apr 8.

Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Rd, Shanghai, 200032, China.

Background: Here we describe the treatments and prognosis for metachronous metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) after initial R0 surgical resection at a large center in China.

Methods: The clinicopathological data and survival outcomes for 108 patients (median age, 54.0 years) with metachronous hepatic metastatic GEP-NETs disease who were initially treated using R0 surgical resection between August 2003 and July 2014 were analyzed using one-way comparisons, survival analysis, and a predictive nomogram. Read More

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http://dx.doi.org/10.1186/s12885-019-5457-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454726PMC
April 2019
1 Read

Non-functional pancreatic neuroendocrine tumours: emerging trends in incidence and mortality.

BMC Cancer 2019 Apr 8;19(1):334. Epub 2019 Apr 8.

Department of General Surgery, Second Affiliated Hospital of Nanchang University, No.1 Minde Load, Nanchang, 330006, China.

Background: Our aim was to determine the epidemiology and recent changes in the trends of non-functional pancreatic neuroendocrine tumours (NF-pNETs) at the population level. In addition, we explored the risk factors that are associated with survival duration.

Methods: Cases were identified form the Surveillance, Epidemiology, and End Results (SEER) Programme database from 2000 to 2014. Read More

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http://dx.doi.org/10.1186/s12885-019-5543-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454719PMC

Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes.

BMC Cancer 2019 Apr 8;19(1):337. Epub 2019 Apr 8.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, 80708, Kaohsiung, Taiwan.

Background: Incidence of renal dysfunction and risks of progression to end-stage renal disease (ESRD) were reported higher in upper urinary tract urothelial carcinoma (UTUC) than in renal cell carcinoma (RCC) patients after unilateral nephrectomy.

Methods: Totally 193 renal cancer patients, including 132 UTUC and 61 RCC, were studied to clarify whether the pathological changes of the kidney remnant removed from nephrectomy and the clinical factors might predict the risk of ESRD. Renal tubulointerstitial (TI) score and global glomerulosclerosis (GGS) rate were examined by one pathologist and two nephrologists independently under same histopathological criteria. Read More

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http://dx.doi.org/10.1186/s12885-019-5414-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454684PMC
April 2019
2 Reads

A specific gene expression signature for visceral organ metastasis in breast cancer.

BMC Cancer 2019 Apr 8;19(1):333. Epub 2019 Apr 8.

Amsterdam UMC, University of Amsterdam, Department of Pathology, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.

Background: Visceral organ metastasis is associated with poor survival outcomes in terms of metastasis free- and overall survival in breast carcinomas. Identification of a gene expression profile in tumours that selects a subpopulation of patients that is more likely to develop visceral organ metastases will help elucidate mechanisms for the development of distant metastases and could be of clinical value. With this study we aimed to determine genomic predictors that would help to distinguish breast cancer patients with more likelihood to develop visceral metastasis. Read More

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http://dx.doi.org/10.1186/s12885-019-5554-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454625PMC

The prognostic significance of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in giant cell tumor of the extremities.

BMC Cancer 2019 Apr 8;19(1):329. Epub 2019 Apr 8.

Department of Orthopaedic Surgery, Huashan Hospital, Fudan University, No. 12 Wulumuqi Road(M), Shanghai, 200040, China.

Background: In this study, the influence of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) on the prognosis of giant cell tumor (GCT) of the extremities were investigated.

Methods: The clinical parameters of 163 patients who were diagnosed with GCT of the extremities between July 2008 and January 2018 were retrospectively analyzed. Optimal cutoff values of NLR and PLR were determined using receiver operating characteristic (ROC) analysis. Read More

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http://dx.doi.org/10.1186/s12885-019-5511-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454707PMC

Abscopal effect of radiation on multiple lung metastases of lung adenocarcinoma: a case report.

BMC Cancer 2019 Apr 8;19(1):336. Epub 2019 Apr 8.

Department of Respiratory Medicine, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa, Chiba, 272-0824, Japan.

Background: Abscopal effect is the out-of-field response to localized irradiation therapy that results in systemic antitumorigenic effects such as the regression of a tumor distant from the target site.

Case Presentation: A 76-year-old woman was diagnosed with pulmonary adenocarcinoma (cT1bN0M0 stage IA), and right upper lobectomy was performed in November 2015. The pathological stage was pT1bN2M0 stage IIIA. Read More

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http://dx.doi.org/10.1186/s12885-019-5566-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454618PMC
April 2019
1 Read

Successful resection of pancreatic metastasis from oesophageal squamous cell carcinoma: a case report and review of the literature.

BMC Cancer 2019 Apr 5;19(1):320. Epub 2019 Apr 5.

Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Oesophageal cancer has a high metastatic potential and poor prognosis, with a significant risk of recurrence after radical resection. However, resected pancreatic metastasis from oesophageal cancer is rare.

Case Presentation: Eleven years prior, a seventy-year-old woman had been treated with transthoracic radical oesophagectomy for oesophageal squamous cell carcinoma. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-019-5549-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451211PMC
April 2019
4 Reads

Novel biomarkers distinguishing pancreatic head Cancer from distal cholangiocarcinoma based on proteomic analysis.

BMC Cancer 2019 Apr 5;19(1):318. Epub 2019 Apr 5.

Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Background: The differentiation between pancreatic head cancer (PHC) and distal cholangiocarcinoma (DCC) can be challenging because of their anatomical and histopathological similarity. This is an important problem, because the distinction has important implications for the treatment of these malignancies. However, there are no biomarkers for the differential diagnosis of PHC and DCC. Read More

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http://dx.doi.org/10.1186/s12885-019-5548-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451218PMC
April 2019
4 Reads

Intratumor heterogeneity index of breast carcinomas based on DNA methylation profiles.

BMC Cancer 2019 Apr 5;19(1):328. Epub 2019 Apr 5.

IHEM-CONICET, Av del libertador, 80, Mendoza, Argentina.

Background: Cancer cells evolve and constitute heterogeneous populations that fluctuate in space and time and are subjected to selection generating intratumor heterogeneity. This phenomenon is determined by the acquisition of genetic/epigenetic alterations and their selection over time which has clinical implications on drug resistance.

Methods: DNA extracted from different tumor cell populations (breast carcinomas, cancer cell lines and cellular clones) were analyzed by MS-MLPA. Read More

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http://dx.doi.org/10.1186/s12885-019-5550-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451266PMC
April 2019
3 Reads

Effectiveness of F-FDG PET/CT in the diagnosis and staging of osteosarcoma: a meta-analysis of 26 studies.

BMC Cancer 2019 Apr 5;19(1):323. Epub 2019 Apr 5.

Department of Orthopaedics, Shandong Provincial Hospital affiliated to Shandong University, No.324, Road Jing Wu Wei Qi, Jinan, 250021, Shandong, China.

Background: Multiple trials have attempted to assess the diagnostic value of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in osteosarcoma with results remaining inconclusive. This study aims to investigate the effectiveness of F-FDG PET and PET/CT in the diagnosis, staging, recurrence and metastasis formation observations of osteosarcoma through systematic review followed by meta-analysis.

Methods: Three electronic databases, Medline/PubMed, Embase and the Cochrane Library were utilized in this study. Read More

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http://dx.doi.org/10.1186/s12885-019-5488-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451259PMC

Changes of N6-methyladenosine modulators promote breast cancer progression.

BMC Cancer 2019 Apr 5;19(1):326. Epub 2019 Apr 5.

Department of Cardiology, The Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, 325027, Zhejiang, China.

Background: Breast cancer (BC) displays striking genetic, epigenetic and phenotypic diversity. N-methyladenosine (m6A) in mRNA has emerged as a crucial epitranscriptomic modification that controls cancer self-renewal and cell fate. However, the key enzymes of m6A expression and function in human breast carcinogenesis remain unclear. Read More

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http://dx.doi.org/10.1186/s12885-019-5538-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451293PMC
April 2019
3 Reads

Identification of ADGRE5 as discriminating MYC target between Burkitt lymphoma and diffuse large B-cell lymphoma.

BMC Cancer 2019 Apr 5;19(1):322. Epub 2019 Apr 5.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, D-10117, Berlin, Germany.

Background: MYC is a heterogeneously expressed transcription factor that plays a multifunctional role in many biological processes such as cell proliferation and differentiation. It is also associated with many types of cancer including the malignant lymphomas. There are two types of aggressive B-cell lymphoma, namely Burkitt lymphoma (BL) and a subgroup of diffuse large cell lymphoma (DLBCL), which both carry MYC translocations and overexpress MYC but both differ significantly in their clinical outcome. Read More

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http://dx.doi.org/10.1186/s12885-019-5537-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451309PMC
April 2019
3 Reads

Serum and cerebrospinal fluid Neudesin concentration and Neudesin Quotient as potential circulating biomarkers of a primary brain tumor.

BMC Cancer 2019 Apr 5;19(1):319. Epub 2019 Apr 5.

Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, ul. Waszyngtona 15A, 15-269, Białystok, Poland.

Background: Despite the previously suggested role of Neudesin in tumorigenesis and its potential as a novel target for the treatment of cancers, its prognostic value has never been examined. Thus, the aim of the study was to evaluate Neudesin concentrations in primary brain tumor patients and make a comparison with non-tumoral individuals.

Methods: Cerebrospinal fluid (CSF) and serum Neudesin concentration was evaluated by means of the ELISA method. Read More

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http://dx.doi.org/10.1186/s12885-019-5525-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451205PMC
April 2019
2 Reads

Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases - the multicenter randomized controlled PUMP trial.

BMC Cancer 2019 Apr 5;19(1):327. Epub 2019 Apr 5.

Department of Surgery, Erasmus MC Cancer Institute, Erasmus University, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.

Background: Recurrences are reported in 70% of all patients after resection of colorectal liver metastases (CRLM), in which half are confined to the liver. Adjuvant hepatic arterial infusion pump (HAIP) chemotherapy aims to reduce the risk of intrahepatic recurrence. A large retrospective propensity score analysis demonstrated that HAIP chemotherapy is particularly effective in patients with low-risk oncological features. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5515-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451273PMC
April 2019
3 Reads

Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls.

BMC Cancer 2019 Apr 5;19(1):325. Epub 2019 Apr 5.

Erasmus MC, Department of Internal Medicine, Academic Center for Thyroid Diseases, European Neuroendocrine Tumor Society center of excellence, P.O Box 2040, 3000, CA, Rotterdam, the Netherlands.

Background: For progressive metastatic medullary thyroid carcinoma (MTC), the available treatment options with tyrosine kinase inhibitors result in grade 3-4 adverse events in a large number of patients. Peptide Receptor Radionuclide Therapy (PRRT), which has also been suggested to be a useful treatment for MTC, is usually well tolerated, but evidence on its effectivity is very limited.

Methods: Retrospective evaluation of treatment effects of PRRT in a highly selected group of MTC patients, with progressive disease or refractory symptoms. Read More

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http://dx.doi.org/10.1186/s12885-019-5540-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451300PMC
April 2019
2 Reads

Intussusception reveals MUTYH-associated polyposis syndrome and colorectal cancer: a case report.

BMC Cancer 2019 Apr 5;19(1):324. Epub 2019 Apr 5.

Diretor do Departamento de Patologia Clínica e Anatomia Patológica do Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: We are reporting a rare case of MUTYH-associated polyposis, a colorectal cancer hereditary syndrome, diagnosticated after an intussusception. Colorectal cancer is an important cause of cancer related mortality that can be manifested by an intussusception, a rare occurrence in adults and almost always related to tumors. Approximately 5% of colorectal cancers can be attributed to syndromes known to cause hereditary colorectal cancer, such as MUTYH-associated polyposis, autosomal genetic syndrome associated with this disease. Read More

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http://dx.doi.org/10.1186/s12885-019-5505-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451307PMC
April 2019
1 Read

Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients.

BMC Cancer 2019 Apr 5;19(1):316. Epub 2019 Apr 5.

Clinical and Experimental Pathology, Department of Immunology, Genetics and Pathology, Uppsala University and Uppsala University Hospital, Rudbeck Laboratory, C5, SE-75185, Uppsala, Sweden.

Background: Regulatory immune cells may modulate the lymphoma microenvironment and are of great interest due to the increasing prevalence of treatment with immunotherapies in lymphoma patients. The aim was to explore the composition of different immune regulatory cell subsets in the peripheral blood of newly diagnosed lymphoma patients in relation to treatment outcome.

Methods: Forty-three newly diagnosed patients with lymphoma were included in the study; 24 with high-grade B-cell lymphoma (HGBCL) and 19 with classical Hodgkin lymphoma (cHL). Read More

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http://dx.doi.org/10.1186/s12885-019-5529-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449984PMC
April 2019
4 Reads

Attention to the principles of exercise training in exercise studies on prostate cancer survivors: a systematic review.

BMC Cancer 2019 Apr 5;19(1):321. Epub 2019 Apr 5.

School of Nursing, Oregon Health and Science University, Portland, Oregon, USA.

Background: The purpose of this review is to update previously published reviews on exercise programming in exercise trials in prostate cancer survivors. We evaluated: 1) the application of the principles of exercise training in prescribed programs; 2) the reporting of the components of the exercise prescription; and 3) the reporting of adherence of participants to the prescribed programs.

Methods: Building upon a previous review, a systematic review was conducted searching OVID Medline, Embase, CINAHL, and SPORTDiscus databases from 2012-2017. Read More

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http://dx.doi.org/10.1186/s12885-019-5520-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451299PMC
April 2019
1 Read