9,551 results match your criteria BMC Cancer[Journal]


Dose-painting multicenter phase III trial in newly diagnosed glioblastoma: the SPECTRO-GLIO trial comparing arm A standard radiochemotherapy to arm B radiochemotherapy with simultaneous integrated boost guided by MR spectroscopic imaging.

BMC Cancer 2019 Feb 21;19(1):167. Epub 2019 Feb 21.

Radiation Oncology Department, Institut Claudius Regaud- Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.

Background: Glioblastoma, a high-grade glial infiltrating tumor, is the most frequent malignant brain tumor in adults and carries a dismal prognosis. External beam radiotherapy (EBRT) increases overall survival but this is still low due to local relapses, mostly occurring in the irradiation field. As the ratio of spectra of choline/N acetyl aspartate> 2 (CNR2) on MR spectroscopic imaging has been described as predictive for the site of local relapse, we hypothesized that dose escalation on these regions would increase local control and hence global survival. Read More

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http://dx.doi.org/10.1186/s12885-019-5317-xDOI Listing
February 2019

Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review.

BMC Cancer 2019 Feb 21;19(1):164. Epub 2019 Feb 21.

Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.

Background: The association of ABO blood groups with gastric cancer risk was proposed decades ago, but the results have been inconsistent.

Methods: We used two single nucleotide polymorphisms to determine ABO genotype in 4932 gastric cancer cases and 6158 controls of Chinese descent, and evaluated the associations of ABO blood groups and genotypes with risk of gastric cancer using multivariable logistic regression models. We also systematically reviewed published literature and performed a meta-analysis of all relevant studies. Read More

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http://dx.doi.org/10.1186/s12885-019-5355-4DOI Listing
February 2019

Are rare cancer survivors at elevated risk of subsequent new cancers?

BMC Cancer 2019 Feb 21;19(1):166. Epub 2019 Feb 21.

Department of Medicine, Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA, USA.

Background: Although rare cancers account for 27% of cancer diagnoses in the US, there is insufficient research on survivorship issues in these patients. An important issue cancer survivors face is an elevated risk of being diagnosed with new primary cancers. The primary aim of this analysis was to assess whether a history of rare cancer increases the risk of subsequent cancer compared to survivors of common cancers. Read More

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http://dx.doi.org/10.1186/s12885-019-5358-1DOI Listing
February 2019

Fasting plasma glucose is an independent predictor of survival in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy.

BMC Cancer 2019 Feb 21;19(1):165. Epub 2019 Feb 21.

Department of Medical Oncology, Thoracic Oncology Division, Catalan Institute of Oncology, Hospital Duran i Reynals, Avda Gran via, 199-203, L'Hospitalet, 08908, Barcelona, Spain.

Background: Diabetes is related with increased cancer mortality across multiple cancer types. Its role in lung cancer mortality is still unclear. We aim to determine the prognostic value of fasting plasma glucose (FPG) and diabetes mellitus in patients with locally advanced non-small cell lung cancer (NSCLC) treated with concurrent chemoradiotherapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5370-5DOI Listing
February 2019

Metastasis in penile corpus cavernosum from esophageal squamous carcinoma after curative resection: a case report.

BMC Cancer 2019 Feb 20;19(1):162. Epub 2019 Feb 20.

Department of Urology, Ningbo Urology & Nephrology Hospital, Ningbo, 315192, Zhejiang, China.

Background: Metastasis in penile corpus cavernosum from esophageal squamous carcinoma is a rare but fatal disease, which was reported in cases without series studies.

Case Presentation: An 84-year-old male smoker, who had a history of curative resection of esophageal squamous carcinoma 12 months before, presented with aggressive dysuria and penis pain for 1 month. Ultrasonic guided biopsy diagnosed metastatic squamous carcinoma from the primary in the esophagus. Read More

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http://dx.doi.org/10.1186/s12885-019-5356-3DOI Listing
February 2019

Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location.

BMC Cancer 2019 Feb 20;19(1):161. Epub 2019 Feb 20.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NTNU, Erling Skjalgssons gt 1, 7030, Trondheim, Norway.

Background: MicroRNAs (miRNA) and other small RNAs are frequently dysregulated in cancer and are promising biomarkers for colon cancer. Here we profile human, virus and bacteria small RNAs in normal and tumor tissue from early stage colon cancer and correlate the expression with clinical parameters.

Methods: Small RNAs from colon cancer tissue and adjacent normal mucosa of 48 patients were sequenced using Illumina high-throughput sequencing. Read More

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http://dx.doi.org/10.1186/s12885-019-5330-0DOI Listing
February 2019

Accuracy of the Delirium Observational Screening Scale (DOS) as a screening tool for delirium in patients with advanced cancer.

BMC Cancer 2019 Feb 19;19(1):160. Epub 2019 Feb 19.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit, De Boelelaan 1117, Rm 3A46, Amsterdam, 1081, HV, the Netherlands.

Background: The Delirium Observation Screening Scale (DOS) was developed to facilitate early recognition of delirium by nurses during routine clinical care. It has shown good validity in a variety of patient populations, but has not yet been validated in hospitalized patients with advanced cancer, although the DOS is commonly used in this setting in daily practice. The aim of this study was to evaluate the accuracy of the DOS in hospitalized patients with advanced cancer using the revised version of the Delirium Rating Scale (DRS-R) as the gold standard. Read More

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http://dx.doi.org/10.1186/s12885-019-5351-8DOI Listing
February 2019

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas.

BMC Cancer 2019 Feb 18;19(1):157. Epub 2019 Feb 18.

Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.

Background: Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15 months, identification and validation of new GBM therapeutic targets is of critical importance.

Results: In this study we tested expression and performed pharmacological characterization of the calcitonin receptor (CTR) as well as other members of the calcitonin family of receptors in high-grade glioma (HGG) cell lines derived from individual patient tumours, cultured in defined conditions. Read More

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http://dx.doi.org/10.1186/s12885-019-5369-yDOI Listing
February 2019

Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro.

BMC Cancer 2019 Feb 18;19(1):158. Epub 2019 Feb 18.

Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, 97331, USA.

Background: Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will frequently undergo a neuroendocrine transition, utilizing autocrine and/or paracrine hormones as growth factors and/or promoters of angiogenesis to facilitate progression and metastasis. While many of these factors and their actions on tumor growth are characterized, some tumor-derived neuropeptides remain unexplored. Read More

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http://dx.doi.org/10.1186/s12885-019-5363-4DOI Listing
February 2019

Stromal cell ratio based on automated image analysis as a predictor for platinum-resistant recurrent ovarian cancer.

BMC Cancer 2019 Feb 18;19(1):159. Epub 2019 Feb 18.

Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.

Background: Identifying high-risk patients for platinum resistance is critical for improving clinical management of ovarian cancer. We aimed to use automated image analysis of hematoxylin & eosin (H&E) stained sections to identify the association between microenvironmental composition and platinum-resistant recurrent ovarian cancer.

Methods: Ninety-one patients with ovarian cancer containing the data of automated image analysis for H&E histological sections were initially reviewed. Read More

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http://dx.doi.org/10.1186/s12885-019-5343-8DOI Listing
February 2019

The efficacy and toxicity of cabazitaxel for treatment of docetaxel-resistant prostate cancer correlating with the initial doses in Japanese patients.

BMC Cancer 2019 Feb 15;19(1):156. Epub 2019 Feb 15.

Department of Urology, Yamagata University, 2-2-2, Iida-nishi, Yamagata, 990-9585, Japan.

Background: We analyzed the efficacy and toxicity of cabazitaxel (CBZ) at high and low initial doses in Japanese patients with docetaxel-resistant castration-resistant prostate cancer (CRPC).

Methods: We retrospectively evaluated 118 patients who received CBZ for docetaxel-resistant CRPC in 10 university hospitals in Japan between 2014 and 2016. The rate of decrease of prostate-specific antigen (PSA), adverse events, progression-free survival (PFS), and overall survival (OS) were compared between patients receiving initially high (≥22. Read More

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http://dx.doi.org/10.1186/s12885-019-5342-9DOI Listing
February 2019
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Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells.

BMC Cancer 2019 Feb 15;19(1):153. Epub 2019 Feb 15.

Australian Institute for Bioengineering and Nanotechnology (Building 75), The University of Queensland, Cooper Rd., St Lucia, Brisbane, QLD, 4072, Australia.

Background: Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells). Previously, we reported that colon and breast cancer stem cells (CSCs) expressed much higher levels of PD-L1 than their parental cells, suggesting they will be more resistant to immune attack.

Methods: We investigated the underlining mechanism of PD-L1 increase in colon CSCs, with a special focus on the effect of insulin and epithelial growth factor (EGF), the two fundamental components to sustain the metabolism and stemness in the culture of CSCs. Read More

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http://dx.doi.org/10.1186/s12885-019-5364-3DOI Listing
February 2019
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Reproductive cancer risk factors among relatives of cancer patients in a tertiary oncology center.

BMC Cancer 2019 Feb 15;19(1):154. Epub 2019 Feb 15.

Department of preventive Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.

Background: The aim of this study was to evaluate the prevalence of some gynecological cancer risk factors in a population of female relatives of cancer patients in Hacettepe University Oncology Hospital. Additionally, what are the levels of the women's awareness /behavior toward available screening tools?

Methods: An individual cancer risk assessment questionnaire has been developed in the Department of Preventive Oncology, which questions the medical history, health behaviors and cancer awareness, as well as their behavior toward available cancer screening tools.

Results: The mean age of the study population was 45. Read More

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http://dx.doi.org/10.1186/s12885-019-5350-9DOI Listing
February 2019
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Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients.

BMC Cancer 2019 Feb 15;19(1):155. Epub 2019 Feb 15.

Department of Oral and Maxillofacial Plastic Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str, 40 06097, Halle/Saale, Germany.

Background: The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, breast cancer and oral squamous cell carcinomas (OSCC). The role of the full length transcript (LGR5FL) in progression and prognosis of several cancers was reported. However, the biological function of three splice variants of LGR5 (LGR5Δ5, LGR5Δ8 and LGR5Δ5-8) has yet to be thoroughly investigated. Read More

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http://dx.doi.org/10.1186/s12885-019-5327-8DOI Listing
February 2019
2 Reads

Correction to: Cervical and breast cancer screening uptake among women with serious mental illness: a data linkage study.

BMC Cancer 2019 02 15;19(1):152. Epub 2019 Feb 15.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Following publication of the original article [1], the authors notified us of an error in the reported percentages in Table 3. Read More

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http://dx.doi.org/10.1186/s12885-019-5357-2DOI Listing
February 2019

Immediate-term cognitive impairment following intravenous (IV) chemotherapy: a prospective pre-post design study.

BMC Cancer 2019 Feb 14;19(1):150. Epub 2019 Feb 14.

Department of Oncology, Cumming School of Medicine, University of Calgary, Tom Baker Cancer Centre, 1331 29 St NW, Calgary, Alberta, T2N 4N2, Canada.

Background: Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset is not known. This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to assess cognitive impairment immediately post-chemotherapy.

Methods: Patients aged 18-80 years receiving first-line intravenous chemotherapy for any stage of breast or colorectal cancer were eligible. Read More

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http://dx.doi.org/10.1186/s12885-019-5349-2DOI Listing
February 2019
1 Read

Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice.

BMC Cancer 2019 Feb 14;19(1):151. Epub 2019 Feb 14.

Amgen Inc., Thousand Oaks, CA, USA.

Background: Chemotherapy-induced thrombocytopenia (CIT) is a potentially serious complication that can lead to chemotherapy dose delays, dose reductions, or discontinuation, and increases the risk of serious bleeding events. The objectives of this study were to characterize the incidence, clinical consequences, and economic costs of CIT in current US clinical practice.

Methods: A retrospective cohort design and data from two US private healthcare claims repositories (01/2010-12/2016) were employed. Read More

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http://dx.doi.org/10.1186/s12885-019-5354-5DOI Listing
February 2019
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Long-term survival and prognostic factors for locally advanced renal cell carcinoma with renal vein tumor thrombus.

BMC Cancer 2019 Feb 13;19(1):144. Epub 2019 Feb 13.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Panjiayuan Nanli 17#, Chaoyang District, 100021, People's Republic of China.

Background: Previous related studies have mainly focused on renal cell carcinoma (RCC) with venous tumor thrombus, specifically inferior vena cava tumor thrombus with renal vein tumor thrombus (RVTT). However, only a few studies have focused on postoperative long-term survival of RCC patients exclusively with RVTT. Our aim was to investigate the independent prognostic factors for locally advanced RCC with RVTT in China. Read More

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http://dx.doi.org/10.1186/s12885-019-5359-0DOI Listing
February 2019
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Sleep disorders associated with risk of prostate cancer: a population-based cohort study.

BMC Cancer 2019 Feb 13;19(1):146. Epub 2019 Feb 13.

Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.

Background: Disrupted sleep rhythms may lead to cancer development. We conducted a population-based cohort study to evaluate the incidence and risk of prostate cancer in patients with sleep disorders (SDs).

Methods: Patients newly diagnosed with SDs between 2000 and 2010 were enrolled from the Taiwan Longitudinal Health Insurance Database. Read More

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http://dx.doi.org/10.1186/s12885-019-5361-6DOI Listing
February 2019
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Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation.

BMC Cancer 2019 Feb 13;19(1):148. Epub 2019 Feb 13.

Division of Pulmonology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Background: A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. However, hypoxia-induced changes in the expression and function of candidate stem cell markers and their possible molecular mechanism is still not understood.

Methods: Lung cell lines were analyzed in normoxic or hypoxic conditions. Read More

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http://dx.doi.org/10.1186/s12885-019-5360-7DOI Listing
February 2019

Patient satisfaction of radiofrequency ablation for symptomatic benign solid thyroid nodules: our experience for 2-year follow up.

BMC Cancer 2019 Feb 13;19(1):147. Epub 2019 Feb 13.

Department of Ultrasound, Beijing Tian Tan Hospital, Capital Medical University, No. 119 West Road of South 4th Ring Road, Fengtai District, Beijing, 100160, China.

Background: The patient satisfaction of symptoms improvement and disease factors that may affect long-term treatment efficacy of radiofrequency ablation (RFA) for non-functioning solid benign thyroid nodules (TNs) over a 2-year follow up study was investigated.

Methods: This retrospective study evaluated 194 non-functioning solid benign TNs of 103 patients. The TNs were categorized as small (≤5 ml), medium (5. Read More

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http://dx.doi.org/10.1186/s12885-019-5338-5DOI Listing
February 2019
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The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis.

BMC Cancer 2019 Feb 13;19(1):145. Epub 2019 Feb 13.

Department of Surgical Oncology, First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, China.

Background: The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and overall survival (OS) in NSCLC patients with brain metastases.

Methods: Searches were performed in PubMed, EmBase, and the Cochrane Library to identify studies evaluating the association of EGFR mutation with OS in NSCLC patients through September 2017. Read More

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http://dx.doi.org/10.1186/s12885-019-5331-zDOI Listing
February 2019
3 Reads

Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice.

BMC Cancer 2019 Feb 13;19(1):149. Epub 2019 Feb 13.

Division of RI application, Korea Institute of Radiological and Medical Sciences, 75 Nowon-Gil, Gongneung-Dong, Nowon-Gu, Seoul, 01812, Korea.

Background: Chemotherapy-induced alopecia has been well documented as a cause of distress to patients undergoing cancer treatment. Almost all traditional chemotherapeutic agents cause severe alopecia. Despite advances in the treatment of chemotherapy-induced alopecia, there is no effective treatment for preventing chemotherapy-induced alopecia. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5323-zDOI Listing
February 2019
2 Reads

Hematologic markers of distant metastases and poor prognosis in gynecological cancers.

BMC Cancer 2019 Feb 12;19(1):141. Epub 2019 Feb 12.

Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Amman, 11941, Jordan.

Background: Despite the recent progress in the development of anti-cancer drugs, the treatment of metastatic tumors is usually ineffective. The systemic inflammatory response performs key roles in different stages of the carcinogenesis process including metastasis. The high neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) were found to be associated with poor survival rates in the majority of solid tumors. Read More

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http://dx.doi.org/10.1186/s12885-019-5326-9DOI Listing
February 2019

Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases.

BMC Cancer 2019 Feb 12;19(1):143. Epub 2019 Feb 12.

Department of Oncology, Huashan Hospital Fudan University, Shanghai, China.

Background: The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines in paired cerebrospinal fluid (CSF) and plasma samples from lung adenocarcinoma (LAC) patients with leptomeningeal metastases (LM).

Methods: Paired CSF cell free DNA (cfDNA), CSF cells, plasma and formalin-fixed and paraffin-embedded (FFPE) samples of primary tumors were collected from 29 LAC patients with LM to detect the mutations by different NGS pipelines. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-019-5348-3DOI Listing
February 2019
2 Reads

Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort.

BMC Cancer 2019 Feb 12;19(1):142. Epub 2019 Feb 12.

Danish Colorectal Cancer Center South, Vejle Hospital, Vejle, Denmark.

Background: Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the prognostic value of Programmed Death Ligand-1 (PD-L1) in a true population-based cohort of patients with stage II CC.

Methods: PD-L1 expression on tumour cells was evaluated by immunohistochemistry in 572 colon cancers. Read More

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http://dx.doi.org/10.1186/s12885-019-5345-6DOI Listing
February 2019

Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis.

BMC Cancer 2019 Feb 11;19(1):138. Epub 2019 Feb 11.

Departments of Microbiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.

Background: Human papillomavirus (HPV) is an etiological agent of cervical cancer. Yet co-factors are believed to be involved in HPV-mediated carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are considered as one of these co-factors. Read More

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http://dx.doi.org/10.1186/s12885-019-5347-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371473PMC
February 2019
1 Read
3.362 Impact Factor

Incidence of childhood CNS tumours in Britain and variation in rates by definition of malignant behaviour: population-based study.

BMC Cancer 2019 Feb 11;19(1):139. Epub 2019 Feb 11.

Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds, UK.

Background: Intracranial and intraspinal tumours are the most numerous solid tumours in children. Some recently defined subtypes are relatively frequent in childhood. Many cancer registries routinely ascertain CNS tumours of all behaviours, while others only cover malignant neoplasms. Read More

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http://dx.doi.org/10.1186/s12885-019-5344-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371471PMC
February 2019
1 Read

Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling.

BMC Cancer 2019 Feb 11;19(1):137. Epub 2019 Feb 11.

Centre de recherche en organogénèse expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec-Université Laval Research Center, QC, Québec, Canada.

Background: Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer progression. Epithelial-mesenchymal transition (EMT) is a key feature of metastatic cells. However, the mechanism by which CAFs induce EMT program in bladder cancer cells remains unclear. Read More

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http://dx.doi.org/10.1186/s12885-019-5353-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371428PMC
February 2019

Trefoil factors peptide-3 is associated with residual invasive breast carcinoma following neoadjuvant chemotherapy.

BMC Cancer 2019 Feb 11;19(1):135. Epub 2019 Feb 11.

Department of Surgery, Tawam Hospital, AlAin, United Arab Emirates.

Background: Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5' promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen and progesterone receptor-DNA binding domains as direct response elements to estrogen and progesterone that are linked to breast functions or steroid regulation. The study was designed to determine the role of TFF3 in breast cancer chemoresistance with the aim of establishing TFF3 expression as a biomarker for drug resistance. Read More

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http://dx.doi.org/10.1186/s12885-019-5316-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371459PMC
February 2019
1 Read

Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer: a post hoc analysis of two non-randomized phase II trials.

BMC Cancer 2019 Feb 12;19(1):134. Epub 2019 Feb 12.

Medical Oncology Department, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Background: The prognostic value of body composition in cancer patients has been widely studied during the last decade. The main finding of these studies is that sarcopenia, or skeletal muscle depletion, assessed by CT imaging correlates with a reduced overall survival (OS). By contrast, the prognostic value of fat mass remains ill-defined. Read More

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http://dx.doi.org/10.1186/s12885-019-5319-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371452PMC
February 2019
1 Read

Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells.

BMC Cancer 2019 Feb 11;19(1):136. Epub 2019 Feb 11.

The Pulmonary Center, Boston University School of Medicine (BUSM), East Concord Street R304, Boston, MA, 02118, USA.

Background: MicroRNAs are noncoding RNA molecules of ~ 22 nucleotides with diagnostic and therapeutic action [Curr Drug Targets, 2015. 16(12): p. 1381-403], affecting the expression of mRNAs involved in invasion, migration, and development [Oncotarget, 2015. Read More

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http://dx.doi.org/10.1186/s12885-019-5337-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371494PMC
February 2019

Cost-effectiveness of bevacizumab plus paclitaxel versus paclitaxel for the first-line treatment of HER2-negative metastatic breast cancer in specialist oncology centers in France.

BMC Cancer 2019 Feb 11;19(1):140. Epub 2019 Feb 11.

HEVA HEOR, Lyon, France.

Background: Evidence from clinical trials suggests that the addition of bevacizumab to chemotherapy in the first-line treatment of patients with HER2-negative metastatic breast cancer improves progression-free survival (PFS) but not overall survival (OS). However, a retrospective analysis of real-world data from the French Comprehensive Cancer Centers (FCCC) through the Epidemiological Strategy and Medical Economics (ESME) Research Program, suggested that in this setting, the addition of bevacizumab may confer a significant benefit in terms of both PFS and OS. A cost-effectiveness analysis was performed to determine the cost-effectiveness of bevacizumab plus paclitaxel versus paclitaxel alone in the first-line treatment of HER2-negative metastatic breast cancer at specialist oncology centers in France. Read More

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http://dx.doi.org/10.1186/s12885-019-5335-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371553PMC
February 2019
1 Read

A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer.

BMC Cancer 2019 Feb 9;19(1):133. Epub 2019 Feb 9.

Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.

Background: Differentiating between cancer patients who will experience metastasis within a short time and who will be long-term survivors without metastasis is a critical aim in healthcare. The microsatellite instability (MSI)-high tumor phenotype is such a differentiator in colorectal cancer, as patients with these tumors are unlikely to experience metastasis. Our aim in this study was to determine if germline genetic variations could further differentiate colorectal cancer patients based on the long-term risk and timing of metastasis. Read More

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http://dx.doi.org/10.1186/s12885-019-5346-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368959PMC
February 2019
1 Read

Breaking silence: a survey of barriers to goals of care discussions from the perspective of oncology practitioners.

BMC Cancer 2019 Feb 8;19(1):130. Epub 2019 Feb 8.

Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada.

Background: Cancer is the leading cause of death in the developed world, and yet healthcare practitioners infrequently discuss goals of care (GoC) with hospitalized cancer patients. We sought to identify barriers to GoC discussions from the perspectives of staff oncologists, oncology residents, and oncology nurses.

Methods: This was a single center survey of staff oncologists, oncology residents, and inpatient oncology nurses. Read More

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http://dx.doi.org/10.1186/s12885-019-5333-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368724PMC
February 2019

Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs.

BMC Cancer 2019 Feb 8;19(1):129. Epub 2019 Feb 8.

Guangzhou University of Chinese Medicine, No.12 Jichang Road, Guangzhou, 510405, Guangdong Province, China.

Background: Serum exosomal microRNAs (miRNAs) have been suggested as novel biomarkers for various diseases, especially gastric cancer (GC). But circulating biomarkers for Chronic atrophic gastritis (CAG) which is defined as precancrerous lesions of GC remain largely elusive. To investigate serum exosomal miRNAs that are differently expressed in CAG patients and Chronic nonatrophic gastritis (CNAG) may be helpful for its diagnosis and therapy. Read More

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http://dx.doi.org/10.1186/s12885-019-5328-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368711PMC
February 2019
2 Reads

Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy.

BMC Cancer 2019 Feb 8;19(1):132. Epub 2019 Feb 8.

Department of Haematology-Oncology, National University Health System, Singapore, Singapore.

Background: There are inconsistencies in the literature regarding the prevalence and assessment of chemotherapy-induced peripheral neuropathy (CIPN). This study explored CIPN natural history and its characteristics in patients receiving taxane- and platinum-based chemotherapy.

Patients And Methods: Multi-country multisite prospective longitudinal observational study. Read More

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http://dx.doi.org/10.1186/s12885-019-5302-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368751PMC
February 2019

Positive response to Icotinib in metastatic lung adenocarcinoma with acquiring EGFR Leu792H mutation after AZD9291 treatment: a case report.

BMC Cancer 2019 Feb 8;19(1):131. Epub 2019 Feb 8.

Department of Medical Oncology, Quzhou People's Hospital, No. 2 Zhongloudi Road, Quzhou, 324000, People's Republic of China.

Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have been emerged as the standard selection in non-small cell lung cancer (NSCLC) patients with EGFR sensitive mutations. However, primary or acquired resistance to EGFR-TKIs seems inevitable, especially to third-generation TKIs, which has appeared absence of effective solutions so far.

Case Presentation: Here we reported a NSCLC patient with EGFR sensitive mutation of deletion within EGFR exon 19, who had been resistant to icotinib and AZD9291 successively after a period of 18 months response duration. Read More

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http://dx.doi.org/10.1186/s12885-019-5352-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368759PMC
February 2019
1 Read

Damage to sebaceous gland and the efficacy of moisturizer after whole breast radiotherapy: a randomized controlled trial.

BMC Cancer 2019 Feb 7;19(1):125. Epub 2019 Feb 7.

Department of Radiation Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.

Background: We conducted a randomized trial to evaluate the efficacy of heparinoid moisturization for radiation dermatitis. We report the time-course of sebum content after whole breast radiotherapy (WBRT) and the efficacy of heparinoid moisturizer.

Methods: Patients receiving adjuvant breast RT were randomly assigned into three groups; prophylaxis, post-WBRT and control groups. Read More

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http://dx.doi.org/10.1186/s12885-019-5334-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367742PMC
February 2019
1 Read

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis.

BMC Cancer 2019 Feb 7;19(1):126. Epub 2019 Feb 7.

Laboratory of Immunology and Biology of Metastasis, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Viale Filopanti 22, I-40126, Bologna, Italy.

Background: Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere with rhabdomyosarcoma growth, no attempt to neutralize IGF2 has been reported. We therefore studied the possibility to hamper rhabdomyosarcoma growth with passive and active immune approaches targeting IGF2. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5339-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367747PMC
February 2019
1 Read

Correction to: Risk of biochemical recurrence based on extent and location of positive surgical margins after robot-assisted laparoscopic radical prostatectomy.

BMC Cancer 2019 02 7;19(1):124. Epub 2019 Feb 7.

Urology Department, Clinique Générale Beaulieu, 1204, Genève, Switzerland.

Following publication of the original article [1], we have been notified that the authors' last names have been incorrectly tagged as first names and vice-versa. The original publication has been corrected. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5296-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366108PMC
February 2019
2 Reads

Tumor classification and biomarker discovery based on the 5'isomiR expression level.

BMC Cancer 2019 Feb 7;19(1):127. Epub 2019 Feb 7.

College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, China.

Background: The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated that the presence or absence of all isomiRs could efficiently discriminate amongst 32 TCGA cancer types. Besides, an effective reduction of distinguishing isomiR features for multiclass tumor discrimination must have a major impact on our understanding of the disease and treatment of cancer. Read More

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http://dx.doi.org/10.1186/s12885-019-5340-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367816PMC
February 2019
1 Read

Risk prediction for breast Cancer in Han Chinese women based on a cause-specific Hazard model.

BMC Cancer 2019 Feb 7;19(1):128. Epub 2019 Feb 7.

Department of Breast Surgery, the Second Hospital of Shandong University, Jinan, 250033, China.

Background: Considering the lack of efficient breast cancer prediction models suitable for general population screening in China. We aimed to develop a risk prediction model to identify high-risk populations, to help with primary prevention of breast cancer among Han Chinese women.

Methods: A cause-specific competing risk model was used to develop the Han Chinese Breast Cancer Prediction model. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5321-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367757PMC
February 2019
3 Reads

Efficacy and safety of RGB-02, a pegfilgrastim biosimilar to prevent chemotherapy-induced neutropenia: results of a randomized, double-blind phase III clinical study vs. reference pegfilgrastim in patients with breast cancer receiving chemotherapy.

BMC Cancer 2019 Feb 6;19(1):122. Epub 2019 Feb 6.

Gedeon Richter Plc, Budapest, Hungary; Gyömröi út 19-21, Budapest, 1103, Hungary.

Background: Treatment with recombinant human granulocyte-colony stimulating factor (G-CSF) is accepted standard for prevention of chemotherapy-induced neutropenia. RGB-02 (Gedeon Richter) is a proposed biosimilar to pegylated G-CSF (Neulasta®, Amgen) with sustained release properties. This is a randomized, comparative, double-blind, multicenter study to evaluate efficacy and safety of RGB-02 in breast cancer patients receiving cytotoxic regimen. Read More

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http://dx.doi.org/10.1186/s12885-019-5329-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364429PMC
February 2019
1 Read

Increased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: a meta analysis.

BMC Cancer 2019 Feb 6;19(1):123. Epub 2019 Feb 6.

Department of Internal Medicine, The Affiliated Chencun Hospital of Shunde Hospital, Southern Medical University, Shunde, 528313, Guangdong, China.

Background: The prognostic value of Ki-67 expression in colorectal cancer patients was controversial. Therefore, this meta analysis was conducted to ascertain the prognostic value of Ki-67 expression in colorectal cancer patients.

Methods: The electronic databases, including EMBASE, PubMed, Cochrane Library and Web of Knowledge database, were searched from January 1970 to July 2017. Read More

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http://dx.doi.org/10.1186/s12885-019-5324-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364416PMC
February 2019

Impact of in vitro driven expression signatures of CD133 stem cell marker and tumor stroma on clinical outcomes in gastric cancers.

BMC Cancer 2019 Feb 4;19(1):119. Epub 2019 Feb 4.

Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea.

Background: The CD133 transmembrane protein is a well-recognized stem cell marker that has been used to isolate putative cancer stem cell populations from gastric cancers (GCs). However, the molecular features or biomarkers underlying CD133 are largely unknown in GCs.

Methods: We performed gene expression profiling of CD133+ and CD133- cells sorted by flow cytometry from three GC cell lines to identify the CD133 expression signatures of GC. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5332-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360664PMC
February 2019
2 Reads

Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2).

BMC Cancer 2019 Feb 4;19(1):121. Epub 2019 Feb 4.

Department of Oncology, University of Oxford, CRUK MRC Oxford Institute for Radiation Oncology, Oxford, UK.

Background: Induction chemotherapy followed by chemoradiation is a treatment option for patients with locally advanced pancreatic cancer (LAPC). However, overall survival is comparable to chemotherapy alone and local progression occurs in nearly half of all patients, suggesting chemoradiation strategies should be optimised. SCALOP-2 is a randomised phase II trial testing the role of radiotherapy dose escalation and/or the addition of the radiosensitiser nelfinavir, following induction chemotherapy of gemcitabine and nab-paclitaxel (GEMABX). Read More

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http://dx.doi.org/10.1186/s12885-019-5307-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360784PMC
February 2019

Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer.

BMC Cancer 2019 Feb 4;19(1):120. Epub 2019 Feb 4.

Institute for Pathology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.

Background: Tumor-infiltrating lymphocytes (TILs) are described as an important immune modulator in the tumor microenvironment and are associated with breast cancer (BC) outcome. The spatial analysis of TILs and TIL subtype distribution at the invasive tumor front (ITF) and the tumor center (TC) might provide further insights into tumor progression.

Methods: We analyzed core biopsies from 87 pre-therapeutic BC patients for total TILs and the following subtypes: CD3+, CD4+, CD8+, CD20+ and CD68+ cells in correlation to clinicopathological parameters and disseminated tumor cells (DTCs) in the bone marrow. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5320-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360695PMC
February 2019
5 Reads

Predictors for use of psychosocial services in patients with metastatic colorectal cancer receiving first line systemic treatment.

BMC Cancer 2019 Feb 1;19(1):115. Epub 2019 Feb 1.

Department of Psychiatry and Amsterdam Public Health research institute, VU University Medical Center, Amsterdam, the Netherlands.

Background: Patients with advanced disease experience high levels of psychological distress, yet there is low uptake of psychosocial services offered to patients who screened positive for distress. In this study we aimed to identify predictors for use of psychosocial services in patients with metastatic colorectal cancer (mCRC) receiving first line chemotherapy enrolled in a prospective cluster randomized trial (CRT).

Methods: Patients completed measures on psychological distress, physical distress, and quality of life at baseline. Read More

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http://dx.doi.org/10.1186/s12885-019-5318-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359772PMC
February 2019

Intraosseous synovial sarcoma of the distal ulna: a case report and review of the literature.

BMC Cancer 2019 Feb 1;19(1):116. Epub 2019 Feb 1.

Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

Background: Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma and rarely occurs primarily in bone. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5325-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359868PMC
February 2019
3 Reads