Search our Database of Scientific Publications and Authors

I’m looking for a

    8744 results match your criteria BMC Cancer[Journal]

    1 OF 175

    A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk.
    BMC Cancer 2018 Jun 15;18(1):658. Epub 2018 Jun 15.
    Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China.
    Background: CHD5 is a conventional tumour-suppressing gene in many tumours. The aim of this study was to determine whether CHD5 variants contribute to the risk of hepatocellular carcinoma (HCC).

    Methods: Gene variants were identified using next-generation sequencing targeted on referenced mutations followed by TaqMan genotyping in two case-control studies. Read More

    MALBAC-based chromosomal imbalance analysis: a novel technique enabling effective non-invasive diagnosis and monitoring of bladder cancer.
    BMC Cancer 2018 Jun 15;18(1):659. Epub 2018 Jun 15.
    Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiangxi Road, Guangzhou, China.
    Background: The gold standard for bladder cancer detection is cystoscopy, which is an invasive procedure that causes discomfort in patients. The currently available non-invasive approaches either show limited sensitivity in low-grade tumours or possess unsatisfying specificity. The aim of the present study is to develop a new non-invasive strategy based on chromosomal imbalance levels to detect bladder cancer effectively. Read More

    Expression of the glucagon-like peptide-1 receptor and its role in regulating autophagy in endometrial cancer.
    BMC Cancer 2018 Jun 15;18(1):657. Epub 2018 Jun 15.
    Department of Obstetrics and Gynecology, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi-ku, Tokyo, 173 0003, Japan.
    Background: A previous report showed that a glucagon-like peptide-1 receptor (GLP-1R) agonist (exenatide) induced apoptosis in endometrial cancer cells. However, the pathophysiological role of GLP-1R in endometrial cancer has not been fully elucidated. Here, we investigated the effects of the GLP-1R agonist liraglutide in endometrial cancer cells and examined the association between GLP-1R expression and clinicopathological characteristics in endometrial cancer patients. Read More

    Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes.
    BMC Cancer 2018 Jun 15;18(1):654. Epub 2018 Jun 15.
    Department of Oncology, Oslo University Hospital, Ullevål, N-0424, Oslo, Norway.
    Background: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear.

    Methods: A population-based survival study among 464 breast cancer cases identified within the Tromsø study was conducted. Read More

    TOPical Imiquimod treatment of residual or recurrent cervical intraepithelial neoplasia (TOPIC-2 trial): a study protocol for a randomized controlled trial.
    BMC Cancer 2018 Jun 15;18(1):655. Epub 2018 Jun 15.
    Department of Obstetrics and Gynecology, Erasmus Medical Center Cancer Institute, Post box 2040, 3000, CA, Rotterdam, The Netherlands.
    Background: Cervical dysplasia (cervical intraepithelial neoplasia (CIN)) is caused by Human Papillomavirus (HPV) and is most common in women of reproductive age. Current treatment of moderate to severe CIN is surgical. This procedure has potential complications, such as haemorrhage, infection and preterm birth in subsequent pregnancies. Read More

    ALDH1A inhibition sensitizes colon cancer cells to chemotherapy.
    BMC Cancer 2018 Jun 15;18(1):656. Epub 2018 Jun 15.
    Laboratory of Molecular Oncology, Cancer Research Institute, Biomedical Research Center of SAS, Dubravska cesta 9, 845 05, Bratislava, Slovakia.
    Background: Recent evidence in cancer research, developed the notion that malignant tumors consist of different subpopulations of cells, one of them, known as cancer stem cells, being attributed many important properties such as enhanced tumorigenicity, proliferation potential and profound multidrug resistance to chemotherapy. Several key stem cells markers were identified in colon cancer. In our study we focused on the aldehyde dehydrogenase type 1 (ALDH1) expression in colon cancer-derived cell lines HT-29/eGFP, HCT-116/eGFP and LS-180/eGFP, and its role in the chemoresistance and tumorigenic potential. Read More

    Increasing incidence of central nervous system (CNS) tumors (2000-2012): findings from a population based registry in Gironde (France).
    BMC Cancer 2018 Jun 14;18(1):653. Epub 2018 Jun 14.
    Equipe EPICENE, Centre INSERM U1219-Bordeaux Population Health Center, Université de Bordeaux, Bordeaux, France.
    Background: Although some countries have observed a stabilization in the incidence of CNS, an increasing incidence has been reported from multiple studies. Recent observations point out to the heterogeneity of incidence trends according to histological subtypes, gender and age-groups. Using a high-quality regional CNS tumor registry, this article describes the trends of CNS tumor incidence for main histological subtypes, including benign and malignant tumors, in the French department of Gironde from 2000 to 2012. Read More

    PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study.
    BMC Cancer 2018 Jun 13;18(1):652. Epub 2018 Jun 13.
    Department of Research, Tumor Genomics Unit, Genomics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, via venezian 1, 20133, Milan, Italy.
    Background: Rhabdomyosarcomas (RMSs) are the most frequent soft tissue sarcoma in children and adolescents, defined by skeletal muscle differentiation and the status of FOXO1 fusions. In pediatric malignancies, in particular RMS, scant and controversial observations are reported about PD-L1 expression as a putative biomarker and few immune checkpoint clinical trials are conducted.

    Methods: PD-L1 assessment was evaluated by immunohistochemistry (IHC) utilizing two anti-PDL1 antibodies, in a pilot cohort of 25 RMS. Read More

    Observational study on the prognostic value of testosterone and adiposity in postmenopausal estrogen receptor positive breast cancer patients.
    BMC Cancer 2018 Jun 13;18(1):651. Epub 2018 Jun 13.
    Laboratory of Medical Statistics and Epidemiology,"Giulio A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan, Via Vanzetti 5, 20133, Milan, Italy.
    Background: Despite the clear endocrine-metabolic relationship between androgenic activity and adiposity, the role of androgens in breast cancer prognosis according to patient's adiposity is scarcely explored. Here, we aimed at investigating the prognostic value of circulating testosterone in association with patient's body mass index (BMI).

    Methods: Circulating testosterone and BMI were evaluated at breast cancer diagnosis in 460 estrogen receptor (ER)-positive postmenopausal patients. Read More

    Effect of perioperative blood transfusion on prognosis of patients with gastric cancer: a retrospective analysis of a single center database.
    BMC Cancer 2018 Jun 11;18(1):649. Epub 2018 Jun 11.
    Department of Gastric Cancer Surgery, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, People's Republic of China.
    Background: The association between perioperative blood transfusion and the prognosis of patients with gastric cancer is still unclear.

    Methods: A total of 1581 patients with gastric cancer who underwent curative gastrectomy from 2000 to 2008 were evaluated. Perioperative blood transfusion was defined as the transfusion of packed red blood cells within seven days before surgery, during surgery, or within the postoperative hospitalization period. Read More

    Dynamic Hyaluronan drives liver endothelial cells towards angiogenesis.
    BMC Cancer 2018 Jun 11;18(1):648. Epub 2018 Jun 11.
    Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
    Background: Angiogenesis, the formation of new blood vessels from pre-existing vasculature is essential in a number of physiological processes such as embryonic development, wound healing as well as pathological conditions like, tumor growth and metastasis. Hyaluronic acid (HA), a high molecular weight polysaccharide, major component of extracellular matrix is known to associate with malignant phenotypes in melanomas and various other carcinomas. Hyaluronic acid binding protein 1 (HABP1) has been previously reported to trigger enhanced cellular proliferation in human liver cancer cells upon its over-expression. Read More

    Detection of intracellular IgD using flow cytometry could be a novel and supplementary method to diagnose IgD multiple myeloma.
    BMC Cancer 2018 Jun 11;18(1):650. Epub 2018 Jun 11.
    Hematology Department, China-Japan Friendship Hospital, Ying-Hua-Yuan East Street, No. 2, Beijing, 100029, China.
    Background: We examined whether detecting the heavy chain of cytoplasmic immunoglobulin D (IgD) by flow cytometry could be used as a supplemental method to diagnose IgD multiple myeloma (MM).

    Methods: Bone marrow (BM) samples of thirty-five patients with MM were collected. Five of them were IgD MM, the rest of thirty were other subtypes of MM. Read More

    Hereditary breast and ovarian cancer in Andalusian families: a genetic population study.
    BMC Cancer 2018 Jun 8;18(1):647. Epub 2018 Jun 8.
    Clinical Oncology Unit Hospitales Universitarios Regional y Virgen de la Victoria. Instituto de Investigación Biomédica de Málaga (IBIMA), Campus Teatinos s/n. 29010, Malaga, Spain.
    Background: The BRCA1/2 mutation profile varies in Spain according to the geographical area studied. The mutational profile of BRCA1/2 in families at risk for hereditary breast and ovarian cancer has not so far been reported in Andalusia (southern Spain).

    Methods: We analysed BRCA1/2 germline mutations in 562 high-risk cases with breast and/or ovarian cancer from Andalusian families from 2010 to 2015. Read More

    A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients.
    BMC Cancer 2018 Jun 8;18(1):646. Epub 2018 Jun 8.
    Medical Oncology Department, Centre Léon Bérard, Lyon, France.
    Background: Synovial Sarcomas (SS) are rare tumors occurring predominantly in adolescent and young adults with a dismal prognosis in advanced phases. We report a first-in-human phase I of monoclonal antibody (OTSA-101) targeting FZD10, overexpressed in most SS but not present in normal tissues, labelled with radioisotopes and used as a molecular vehicle to specifically deliver radiation to FZD10 expressing SS lesions.

    Methods: Patients with progressive advanced SS were included. Read More

    Decreased expression of SRY-box containing gene 30 is related to malignant phenotypes of human bladder cancer and correlates with poor prognosis.
    BMC Cancer 2018 Jun 7;18(1):642. Epub 2018 Jun 7.
    Department of Urinary Surgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
    Background: In human pulmonary malignancies, the SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene. Nevertheless, its molecular role and clinical effects remains unknown in bladder cancer.

    Methods: SOX30 mRNA expression was quantified in bladder cancer tissue, paired adjacent normal tissue, and cell lines with qRT-PCR. Read More

    p300 promotes proliferation, migration, and invasion via inducing epithelial-mesenchymal transition in non-small cell lung cancer cells.
    BMC Cancer 2018 Jun 7;18(1):641. Epub 2018 Jun 7.
    Department of Medical Oncology, Sun Yat-sen University Cancer Center, 651 East Dongfeng Road, 510060, Guangzhou City, Guangdong Province, People's Republic of China.
    Background: Histone acetyltransferase p300 is a crucial transcriptional coactivator and has been implicated as a poor prognostic factor in human cancers. However, little is known about the substantial functions and mechanisms of p300 in NSCLC proliferation and distant metastasis.

    Methods: We constructed p300 down-regulated and up-regulated cell lines through RNAi and recombinant plasmid transfection. Read More

    Projected cervical Cancer incidence in Swaziland using three methods and local survey estimates.
    BMC Cancer 2018 Jun 7;18(1):639. Epub 2018 Jun 7.
    Discipline of Public Health, School of Nursing and Public Health, University of KwaZulu-Natal, Howard College Campus, 2nd Floor George Campbell Building, Mazisi Kunene Road, Durban, 4041, South Africa.
    Background: The scarcity of country data (e.g. a cancer registry) for the burden of cervical cancer (CC) in low-income countries (LCIs) such as Swaziland remains a huge challenge. Read More

    A patient with plasmablastic lymphoma achieving long-term complete remission after thalidomide-dexamethasone induction and double autologous stem cell transplantation: a case report.
    BMC Cancer 2018 Jun 8;18(1):645. Epub 2018 Jun 8.
    Institute of Haematology "L. e A. Seràgnoli", University of Bologna, Via Massarenti, 9 -40138, Bologna, Italy.
    Background: No standard of care is established for plasmablastic lymphoma (PBL) and prognosis remains extremely poor, given that patients relapse early after chemotherapy and display resistance to commonly applied cytostatic drugs.

    Case Presentation: We report a case of nodal, HIV-unrelated PBL in a patient who achieved and maintained a very long lasting complete remission after an intensive therapy consisting consisting of thalidomide plus dexamethasone followed by a consolidation with double autologous stem cell transplantation. Our approach was based on the full application of a standard multiple myeloma treatment and, to the best of our knowledge, it represents the only reported experience so far. Read More

    Deep sequencing of human papillomavirus positive loco-regionally advanced oropharyngeal squamous cell carcinomas reveals novel mutational signature.
    BMC Cancer 2018 Jun 7;18(1):640. Epub 2018 Jun 7.
    Department of Otorhinolaryngology - Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
    Background: The genetic profile for human papilloma virus positive (HPV+) oropharyngeal squamous cell carcinomas (OPSCC) remains largely unknown. The purpose of this study was to sequence tissue material from a large cohort of locoregionally-advanced HPV+ OPSCCs.

    Methods: We performed targeted deep sequencing of 395 cancer-associated genes in 114 matched tumor/normal loco-regionally advanced HPV+ OPSCCs. Read More

    Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching study.
    BMC Cancer 2018 Jun 7;18(1):643. Epub 2018 Jun 7.
    Department of Hepatobiliary Oncology, Cancer Center of Sun Yat-sen University, Guangzhou, 510060, China.
    Background: The optimal therapeutic strategy in UICC stage T3 hepatocellular carcinoma (HCC) patients that maximizes both safety and long-term outcome has not yet been determined. Our aim was to compare clinical outcomes following hepatic resection (HR) versus transarterial chemoembolization (TACE) for stage T3 HCC.

    Methods: From 2005 to 2013, 1179 patients with T3 HCC who underwent HR or TACE were divided into two groups, HR group (n = 280) or TACE group (n = 899). Read More

    A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women.
    BMC Cancer 2018 Jun 5;18(1):637. Epub 2018 Jun 5.
    Department of Environmental Health Sciences, Yale School of Public Health, 60 College St, New Haven, CT, 06520, USA.
    Background: Growing evidence demonstrates that exposure to organophosphate flame retardants (PFRs) is widespread and that these chemicals can alter thyroid hormone regulation and function. We investigated the relationship between PFR exposure and thyroid cancer and whether individual or temporal factors predict PFR exposure.

    Methods: We analyzed interview data and spot urine samples collected in 2010-2013 from 100 incident female, papillary thyroid cancer cases and 100 female controls of a Connecticut-based thyroid cancer case-control study. Read More

    An implementation of normal distribution based segmentation and entropy controlled features selection for skin lesion detection and classification.
    BMC Cancer 2018 Jun 5;18(1):638. Epub 2018 Jun 5.
    College of Computer and Information Sciences, King Saud University, Riyadh, Saudi Arabia.
    Background: Melanoma is the deadliest type of skin cancer with highest mortality rate. However, the annihilation in its early stage implies a high survival rate therefore, it demands early diagnosis. The accustomed diagnosis methods are costly and cumbersome due to the involvement of experienced experts as well as the requirements for the highly equipped environment. Read More

    Itraconazole treatment of primary malignant melanoma of the vagina evaluated using positron emission tomography and tissue cDNA microarray: a case report.
    BMC Cancer 2018 Jun 4;18(1):630. Epub 2018 Jun 4.
    Department of Surgical Pathology, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo, 663-8501, Japan.
    Background: Primary malignant melanoma of the vagina is extremely rare, with a poorer prognosis than cutaneous malignant melanoma. Previous studies have explored the repurposing of itraconazole, a common oral anti-fungal agent, for the treatment of various cancers. Here, we describe a patient with metastatic, unresectable vaginal malignant melanoma treated with 200 mg oral itraconazole twice a day in a clinical window-of-opportunity trial. Read More

    Solitary metastasis to a superior mediastinal lymph node after distal gastrectomy for gastric cancer: a case report.
    BMC Cancer 2018 Jun 4;18(1):627. Epub 2018 Jun 4.
    Department of Surgery, North Alps Medical Center Azumi Hospital, 3207-1, Ikeda, Ikeda-cho, Kitaazumi-gun, Nagano, 399-8695, Japan.
    Background: Mediastinal lymph node metastases occasionally occur in patients of advanced gastric cancer of the cardia with esophageal invasion, but they rarely occur in patients with gastric cancer of other sites. This report describes a case of a solitary metastasis to t a superior mediastinal lymph node after distal gastrectomy for gastric cancer of the antrum.

    Case Presentation: A 70-year-old man underwent curative distal gastrectomy for advanced gastric cancer of the antrum (pT2pN2M0, stage IIB). Read More

    Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial.
    BMC Cancer 2018 Jun 4;18(1):633. Epub 2018 Jun 4.
    Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, 734-8551, Japan.
    Background: In patients with advanced hepatocellular carcinoma (HCC), evidence is unclear as to whether hepatic arterial infusion chemotherapy (HAIC) or sorafenib is superior. We performed a prospective, open-label, non-comparative phase II study to assess survival with HAIC or HAIC converted to sorafenib.

    Methods: Fifty-five patients were prospectively enrolled. Read More

    Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment.
    BMC Cancer 2018 Jun 5;18(1):636. Epub 2018 Jun 5.
    Cancer Research UK Edinburgh Centre and Division of Pathology Laboratory, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
    Background: Novel therapeutic approaches are required to treat ovarian cancer and dependency on glycolysis may provide new targets for treatment. This study sought to investigate the variation of expression of molecular components (GLUT1, HKII, PKM2, LDHA) of the glycolytic pathway in ovarian cancers and the effectiveness of targeting this pathway in ovarian cancer cell lines with inhibitors.

    Methods: Expression of GLUT1, HKII, PKM2, LDHA were analysed by quantitative immunofluorescence in a tissue microarray (TMA) analysis of 380 ovarian cancers and associations with clinicopathological features were sought. Read More

    Perceptions of and decision making about clinical trials in adolescent and young adults with Cancer: a qualitative analysis.
    BMC Cancer 2018 Jun 4;18(1):629. Epub 2018 Jun 4.
    Adolescent and Young Adult Program, Princess Margaret Cancer Centre, Toronto, Canada.
    Background: Adolescent and young adults (AYA) enrolment rates into cancer clinical trials (CCT) are the lowest of any age group globally. As AYA have distinct biological, psychosocial and relational needs, we aimed to explore any unique factors influencing their CCT decision-making process, including AYA-specific perceptions or attitudes towards CCT.

    Methods: Qualitative interpretive descriptive methodology was used to explore AYA perceptions and decision-making related to CCT. Read More

    Body mass index and lung cancer risk in never smokers: a meta-analysis.
    BMC Cancer 2018 Jun 5;18(1):635. Epub 2018 Jun 5.
    Department of Thoracic and Cardiovascular Surgery, the First Affiliated Hospital of Henan University, No. 357 Ximen Street, Kaifeng City, 475000, Henan Province, China.
    Background: Obesity is found to increase the risk of most cancer types, but reduce lung cancer risk in many studies. However, the association between obesity and lung cancer is still controversial, mainly owing to the confounding effect of smoking.

    Methods: Eligible studies were identified from electric databases to July 1, 2017. Read More

    Long-term trends in pancreatic cancer mortality in Spain (1952-2012).
    BMC Cancer 2018 Jun 4;18(1):625. Epub 2018 Jun 4.
    Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain.
    Background: Pancreatic cancer is acquiring increasing prominence as a cause of cancer death in the population. The purpose of this study was to analyze long-term pancreatic cancer mortality trends in Spain and evaluate the independent effects of age, death period and birth cohort on these trends.

    Methods: Population and mortality data for the period 1952-2012 were obtained from the Spanish National Statistics Institute. Read More

    Pregnancy-associated breast cancer in rural Rwanda: the experience of the Butaro Cancer Center of Excellence.
    BMC Cancer 2018 Jun 5;18(1):634. Epub 2018 Jun 5.
    Harvard Medical School, Boston, MA, USA.
    Background: Breast cancer is the most common malignancy encountered during pregnancy. However, the burden of pregnancy-associated breast cancer (PABC) and subsequent care is understudied in sub-Saharan Africa (SSA). Here, we describe the characteristics, diagnostic delays and treatment of women with PABC seeking care at a rural cancer referral facility in Rwanda. Read More

    One-year mortality and Periprosthetic infection rates after Total knee Arthroplasty in Cancer patients: a population-based cohort study.
    BMC Cancer 2018 Jun 4;18(1):628. Epub 2018 Jun 4.
    Department of Applied Cosmetology, National Tainan Junior College of Nursing, Tainan, Taiwan.
    Background: Knowledge on periprosthetic infection and mortality rate following total knee arthroplasty (TKA) is essential for justifying this treatment in patients with cancer; however, relevant data from population-based studies are lacking. Therefore, we examined 1-year periprosthetic infection, mortality, and 5-year relative survival rates in cancer patients who underwent TKA.

    Methods: This is a population-based cohort study based on analysis of the Taiwan National Health Insurance Research Database. Read More

    Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer.
    BMC Cancer 2018 Jun 4;18(1):626. Epub 2018 Jun 4.
    Department of Animal Physiology, Veterinary Medicine School, Complutense University of Madrid, Madrid, Spain.
    Background: Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet. There are no previous studies on its effects in human inflammatory breast cancer or canine inflammatory mammary cancer that is the most aggressive type of breast cancer.

    Methods: The aim of this study was to analyze the effect of indole-3-carbinol on a SCID mice xenograft model of canine inflammatory mammary cancer, using equivalent human oral dose as a preventive therapy in humans for 3 weeks. Read More

    Survival after the diagnosis of breast or colorectal cancer in the GAZA Strip from 2005 to 2014.
    BMC Cancer 2018 Jun 4;18(1):632. Epub 2018 Jun 4.
    Cancer Epidemiology Unit, IRCCS Centro di Riferimento Oncologico, Aviano, Italy.
    Background: Within a dramatic socio-political context, cancer represents a growing health burden in the Gaza Strip. We investigated the survival experience of people diagnosed with breast (BC) or colorectal (CRC) cancer from 2005 to 2014.

    Methods: Data included 1360 BC cases (median age 55. Read More

    MiR-199a-3p affects the multi-chemoresistance of osteosarcoma through targeting AK4.
    BMC Cancer 2018 Jun 4;18(1):631. Epub 2018 Jun 4.
    Department of orthopaedic surgery, the third people's hospital of Hefei, Hefei, 230031, Anhui, China.
    Background: MicroRNAs (miRNAs) play vital roles in regulating various biological processes. The dysregulations of miRNAs may result in severe human diseases, including cancer.

    Methods: We performed the qRT-PCR, western blot and the luciferase reporter assays to test whether Adenylate Kinase 4 (AK4) is the target of miR-199a-3p. Read More

    Compressed collagen and decellularized tissue - novel components in a pipeline approach for the study of cancer metastasis.
    BMC Cancer 2018 Jun 1;18(1):622. Epub 2018 Jun 1.
    Cell Migration Lab, School of Biological Sciences, University of Reading, Reading, RG6 6UB, UK.
    Background: Metastasis is a complex process which is difficult to study and model. Experimental ingenuity is therefore essential when seeking to elucidate the biological mechanisms involved. Typically, in vitro models of metastasis have been overly simplistic, lacking the characteristic elements of the tumour microenvironment, whereas in vivo models are expensive, requiring specialist resources. Read More

    Reconsideration of the optimal minimum lymph node count for young colon cancer patients: a population-based study.
    BMC Cancer 2018 Jun 1;18(1):623. Epub 2018 Jun 1.
    Department of Colorectal Surgery, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Background: Currently, young colon cancer (CC) patients continue to increase and represent a heterogeneous patient group. The aim of this study was to explore the optimal minimum lymph node count after CC resection for young patients.

    Methods: We performed a comprehensive search of the Surveillance, Epidemiology, and End Results (SEER) database, 2360 CC patients aged from 20 to 40 were analyzed. Read More

    Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway.
    BMC Cancer 2018 Jun 1;18(1):621. Epub 2018 Jun 1.
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
    Background: It is essential to understand the mechanisms responsible for hepatocellular carcinoma (HCC) progression and chemoresistance in order to identify prognostic biomarkers as well as potential therapeutic avenues. Recent findings have shown that SLIT3 appears to function as a novel tumor suppressor gene in various types of cancers, yet its clinical correlation and role in HCC has not been understood clearly.

    Methods: We determined the transcript levels of Slit3 in tumor and adjacent normal tissues within two cohorts (N = 40 and 25) of HCC patients, and correlated the gene expression with the clinicopathological data. Read More

    Differences in LC3B expression and prognostic implications in oropharyngeal and oral cavity squamous cell carcinoma patients.
    BMC Cancer 2018 Jun 1;18(1):624. Epub 2018 Jun 1.
    Sydney Medical School, The University of Sydney, Sydney, Australia.
    Background: This study examined the prognostic significance of microtubule-associated protein light chain 3B (LC3B) expression in oropharyngeal and oral cavity squamous cell carcinoma (SCC). The prognostic significance of LC3B expression in relation to human papillomavirus (HPV) status in oropharyngeal SCC was also examined.

    Methods: Tissue microarrays (TMAs) were constructed from formalin-fixed, paraffin-embedded oropharyngeal (n = 47) and oral cavity (n = 95) SCC tissue blocks from patients with long-term recurrence and overall survival data (median = 47 months). Read More

    Risk of second primary Cancer among bladder Cancer patients: a population-based cohort study in Korea.
    BMC Cancer 2018 May 31;18(1):617. Epub 2018 May 31.
    Cancer Registration and Statistics Branch, National Cancer Center, Goyang, Korea.
    Background: For the expanding population of bladder cancer survivors in Korea, the development of subsequent cancers is a significant concern. Here, we provide the second primary cancer incidence rates and types in Korean patients with bladder cancer.

    Methods: Using population-based data from the Korea Central Cancer Registry from 1993 to 2013, we studied the standardized incidence ratios among 48,875 individuals with an initial diagnosis of bladder cancer. Read More

    The outcomes and prognostic factors in patients with osteosarcoma according to age: a Japanese nationwide study with focusing on the age differences.
    BMC Cancer 2018 May 31;18(1):614. Epub 2018 May 31.
    Department of Musculoskeletal Oncology and Rehabilitation Medicine, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
    Background: Few reports have described clinical features, prognosis and prognostic factors of osteosarcoma patients according to age.

    Methods: Using the Bone and Soft Tissue Tumor Registry in Japan, we identified 1043 osteosarcoma patients including 760 who were younger than 40 years, 173 aged between 41 and 64 years, and 110 patients older than 65 years. We extracted data on patient demographics and prognosis. Read More

    ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination.
    BMC Cancer 2018 May 31;18(1):613. Epub 2018 May 31.
    Department of Pathology, University of Alberta, Edmonton, AB, Canada.
    Background: We recently reported that STAT1 plays a tumor suppressor role, and ERK was inversely correlation with STAT1 expression in esophageal squamous cell carcinoma (ESCC). Here, we investigated the mechanism(s) that are responsible for the ERK regulates STAT1 in ESCC.

    Methods: We performed the immunoprecipitation (IP) to detect the ubiquitin of STAT1 upon MEK transfection or U0126 treatment and co-IP to confirm the binding of STAT1 and ERK in ESCC cell lines. Read More

    A case of pulmonary adenocarcinoma showing rapid progression of peritoneal dissemination after immune checkpoint inhibitor therapy.
    BMC Cancer 2018 May 31;18(1):620. Epub 2018 May 31.
    Department of Respiratory Medicine, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa, Chiba, 272-0824, Japan.
    Background: Immune checkpoint inhibitors are standard treatments for non-small cell lung cancer. Unique cases with paradoxical acceleration of the disease after immunotherapy have been reported. These have been described as cases of hyperprogressive disease. Read More

    Obesity as risk factor for subtypes of breast cancer: results from a prospective cohort study.
    BMC Cancer 2018 May 31;18(1):616. Epub 2018 May 31.
    Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.
    Background: Earlier epidemiological studies indicate that associations between obesity and breast cancer risk may not only depend on menopausal status and use of exogenous hormones, but might also differ by tumor subtype. Here, we evaluated whether obesity is differentially associated with the risk of breast tumor subtypes, as defined by 6 immunohistochemical markers (ER, PR, HER2, Ki67, Bcl-2 and p53, separately and combined), in the prospective EPIC-Germany Study (n = 27,012).

    Methods: Formalin-fixed and paraffin-embedded (FFPE) tumor tissues of 657 incident breast cancer cases were used for histopathological analyses. Read More

    Apatinib treatment for KIT- and KDR-amplified angiosarcoma: a case report.
    BMC Cancer 2018 May 31;18(1):618. Epub 2018 May 31.
    3D Medicine Inc. Shanghai, Shanghai, 201114, People's Republic of China.
    Background: Metastatic or relapsed angiosarcoma has a poor prognosis and the efficacy of conventional chemotherapy is often limited. Apatinib, a novel tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptor-2 (VEGFR2), has been approved for the treatment of advanced gastric cancer.

    Case Presentation: Herein, we report a patient with advanced angiosarcoma, who received apatinib at a daily dose of 250 to 725 mg, resulting in a partial response for three months, which may be related to Kinase Insert Domain Receptor (KDR) gene amplification. Read More

    Usefulness of combined androgen blockade therapy with gonadotropin-releasing hormone antagonist for bone metastatic prostate cancer with pretreatment prostate-specific antigen level ≥ 50 ng/mL.
    BMC Cancer 2018 May 31;18(1):619. Epub 2018 May 31.
    Department of Urology, Saku Central Hospital, 197 Usuda, Saku, Nagano, 384-0393, Japan.
    Background: This study was performed to examine the usefulness of combined androgen blockade (CAB) therapy with a gonadotropin-releasing hormone (GnRH) antagonist (CAB-antagonist therapy), instead of CAB therapy with GnRH agonist (CAB-agonist therapy) against very high-risk prostate cancer (Pca).

    Methods: We retrospectively studied 84 Pca patients with pretreatment prostate-specific antigen (PSA) level ≥ 50 ng/mL, who were pathologically diagnosed between January 2007 and December 2016. GnRH antagonist was administered to 34 patients and GnRH agonist was administered to 50 patients. Read More

    PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer.
    BMC Cancer 2018 May 31;18(1):612. Epub 2018 May 31.
    Department of Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246, Hamburg, Germany.
    Background: Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear.

    Methods: To clarify contradictory findings on the prognostic role of PSCA expression, a tissue microarray containing 13,665 prostate cancers was analyzed by immunohistochemistry.

    Results: PSCA staining was absent in normal epithelial and stromal cells of the prostate. Read More

    Trends in lung cancer emergency presentation in England, 2006-2013: is there a pattern by general practice?
    BMC Cancer 2018 May 31;18(1):615. Epub 2018 May 31.
    University College London, Department of Applied Health Research, London, UK.
    Background: Emergency presentations (EP) represent over a third of all lung cancer admissions in England. Such presentations usually reflect late stage disease and are associated with poor survival. General practitioners (GPs) act as gate-keepers to secondary care and so we sought to understand the association between GP practice characteristics and lung cancer EP. Read More

    IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway.
    BMC Cancer 2018 May 30;18(1):609. Epub 2018 May 30.
    School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan.
    Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The disease recurrent rate is relatively high resulted in poor 5-year survival in advanced HCC. Cancer stem cells (CSCs) have been considered to be one of the main mechanisms for chemoresistance, metastasis, and recurrent disease. Read More

    Evaluation of metastatic niches in distant organs after surgical removal of tumor-bearing lymph nodes.
    BMC Cancer 2018 May 30;18(1):608. Epub 2018 May 30.
    Laboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, Miyagi, 980-8575, Japan.
    Background: Surgical removal of primary tumors can promote the incidence of tumor metastasis. However, molecular mechanisms underlying this process remain unclear.

    Methods: We inoculated tumor cells expressing luciferase gene  into subiliac lymph node (SiLN) of the MXH10/Mo-lpr/lpr mice. Read More

    Aggregation of lipid rafts activates c-met and c-Src in non-small cell lung cancer cells.
    BMC Cancer 2018 May 30;18(1):611. Epub 2018 May 30.
    The First Oncology Department, Shengjing Hospital affiliated with China Medical University, Shenyang, 110004, China.
    Background: Activation of c-Met, a receptor tyrosine kinase, induces radiation therapy resistance in non-small cell lung cancer (NSCLC). The activated residual of c-Met is located in lipid rafts (Duhon et al. Mol Carcinog 49:739-49, 2010). Read More

    1 OF 175