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    Survival time following resection of intracranial metastases from NSCLC-development and validation of a novel nomogram.
    BMC Cancer 2017 Nov 21;17(1):774. Epub 2017 Nov 21.
    Department of oncology, Huashan Hospital Fudan University, Shanghai, 200040, China.
    Background: Brain metastases (BM) from non-small cell lung cancer (NSCLC) are the most frequent intracranial tumors. To identify patients who might benefit from intracranial surgery, we compared the six existing prognostic indexes(PIs) and built a nomogram to predict the survival for NSCLC with BM before they intended to receive total intracranial resection in China.

    Methods: First, clinical data of NSCLC presenting with BM were retrospectively reviewed. Read More

    Cost-effectiveness analysis of the introduction of S-1 therapy for first-line metastatic breast cancer treatment in Japan: results from the randomized phase III SELECT BC trial.
    BMC Cancer 2017 Nov 17;17(1):773. Epub 2017 Nov 17.
    Division of Breast and Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
    Background: This study evaluated the cost-effectiveness of replacing standard intravenous therapy (taxane) with oral S-1 therapy for first-line metastatic breast cancer treatment.

    Methods: This cost-effectiveness analysis was based on data from a randomized phase III trial (SELECT BC). As cost-effectiveness was a secondary endpoint of the SELECT BC trial, some of the randomized patients participated in an EQ-5D survey (N = 391) and health economic survey (N = 146). Read More

    Process quality of decision-making in multidisciplinary cancer team meetings: a structured observational study.
    BMC Cancer 2017 Nov 17;17(1):772. Epub 2017 Nov 17.
    Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
    Background: The quality of decision-making in multidisciplinary team meetings (MDTMs) depends on the quality of information presented and the quality of team processes. Few studies have examined these factors using a standardized approach. The aim of this study was to objectively document the processes involved in decision-making in MDTMs, document the outcomes in terms of whether a treatment recommendation was given (none vs. Read More

    Cytoreductive surgery and Hyperthermic intra-operative peritoneal chemotherapy with Cisplatin for gastric peritoneal Carcinomatosis Monocentric phase-2 nonrandomized prospective clinical trial.
    BMC Cancer 2017 Nov 17;17(1):771. Epub 2017 Nov 17.
    Department of Digestive Oncology, University Hospitals KU Leuven, Leuven, Belgium.
    Background: Cytoreductive surgery (CRS) plus hyperthermic intra-operative peritoneal chemotherapy (HIPC) for gastric peritoneal carcinomatosis (PC) is controversial, and selection criteria for this treatment modality are lacking.

    Methods: Thirty-two patients (F/M ratio 12/20; median (range) age 58 (32-75) years) underwent CRS + HIPC with cisplatin for PC from gastric adenocarcinoma in 2010-2014. This monocentric phase-2 nonrandomized prospective study with a power of 90% aimed to improve the 1-year overall survival (OS) rate with 40% (historical reference of 52% to 72%). Read More

    Risk factors associated with the progression and metastases of hindgut neuroendocrine tumors: a retrospective study.
    BMC Cancer 2017 Nov 16;17(1):769. Epub 2017 Nov 16.
    Department of Pathology, Kanagawa Cancer Center, 2-3-2, Nakao, Asahi-Ku, Yokohama, Kanagawa, 241-8515, Japan.
    Background: The worldwide incidence of neuroendocrine tumors (NETs) has increased remarkably, with the hindgut being the second most common site for such tumors. However, the mechanisms underlying progression and metastasis of hindgut NETs are unclear. A retrospective study was conducted to elucidate these mechanisms. Read More

    Renal failure during chemotherapy: renal biopsy for assessing subacute nephrotoxicity of pemetrexed.
    BMC Cancer 2017 Nov 16;17(1):770. Epub 2017 Nov 16.
    Pitié Salpêtrière Hospital, 75013, Paris, France.
    Background: Pemetrexed, a multitargeted antifolate cytotoxic agent, is currently used primarily in combination with cisplatin for metastatic non-small cell lung cancer and for malignant mesothelioma. Acute renal toxicity of pemetrexed has been recently described with polychemotherapy, in which the individual responsibility of each drug is difficult to establish. Only one recent report documents renal involvement in long-term exposed patients. Read More

    DETECT I & DETECT II: a study protocol for a prospective multicentre observational study to validate the UroMark assay for the detection of bladder cancer from urinary cells.
    BMC Cancer 2017 Nov 15;17(1):767. Epub 2017 Nov 15.
    Division of Surgery and Interventional Science, University College London, 74 Huntley Street, London, WC1E 6AU, UK.
    Background: Haematuria is a common finding in general practice which requires visual inspection of the bladder by cystoscopy as well as upper tract imaging. In addition, patients with non-muscle invasive bladder cancer (NMIBC) often require surveillance cystoscopy as often as three monthly depending on disease risk. However, cystoscopy is an invasive procedure which is uncomfortable, requires hospital attendance and is associated with a risk of urinary tract infection. Read More

    In response to Fogarty et al. and why adjuvant whole brain radiotherapy is not recommended routinely.
    BMC Cancer 2017 Nov 15;17(1):768. Epub 2017 Nov 15.
    Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, 4102, Australia.
    The routine use of adjuvant whole brain radiotherapy (AWBRT) after surgery or stereotactic radiosurgery is now discouraged by a number of international expert panels. Three decades of randomised studies have shown that, although AWBRT improves radiological measures of intracranial disease control, the clinical benefit is unclear and it is also associated with inferior quality of life and neurocognitive function. The number of patients with melanoma in these trials was low, but data suggesting that treatment-related side effects should vary according to histology of the primary malignancy are lacking. Read More

    Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression.
    BMC Cancer 2017 Nov 15;17(1):766. Epub 2017 Nov 15.
    School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
    Background: Expression of caveolin-1 (Cav-1) is frequently altered in many human cancers and both tumor suppression and promotion functions of Cav-1 have been suggested based on its expression status. However, it remains unanswered how Cav-1 provokes opposite effects in different cancers or different phases of tumor progression.

    Methods: To explore the implication of Cav-1 alteration in gastric tumorigenesis, the expression and mutational status of Cav-1 and its effects on tumor cell growth were characterized. Read More

    Analysis of factors influencing molecular testing at diagnostic of colorectal cancer.
    BMC Cancer 2017 Nov 14;17(1):765. Epub 2017 Nov 14.
    Department of Gastroenterology, Poitiers University Hospital, 2 rue de la Milétrie, 86000, Poitiers Cedex, France.
    Background: The aim of the study was to evaluate the current rate of molecular testing prescription (KRAS codons 12/13, BRAF and microsatellite instability (MSI)) in newly diagnosed colorectal cancer (CRC) patients and to determine which factors influence testing.

    Methods: All incident CRC cases in 2010 were identified in the Poitou-Charentes General Cancer Registry. The exhaustive molecular testing performed was accessed in the French molecular genetics platform. Read More

    Preoperative T staging using CT colonography with multiplanar reconstruction for very low rectal cancer.
    BMC Cancer 2017 Nov 14;17(1):764. Epub 2017 Nov 14.
    Colorectal Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 1040045, Japan.
    Background: Preoperative T staging of lower rectal cancer is an important criterion for selecting intersphincteric resection (ISR) or abdominoperineal resection (APR) as well as selecting neoadjuvant therapy. The aim of this study was to evaluate the accuracy of preoperative T staging using CT colonography (CTC) with multiplanar reconstruction (MPR), in which with the newest workstation the images can be analyzed with a slice thickness of 0.5 mm. Read More

    Effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs on the incidence of recurrent colorectal adenomas: a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials.
    BMC Cancer 2017 Nov 14;17(1):763. Epub 2017 Nov 14.
    School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 46150, Bandar Sunway, Selangor, Malaysia.
    Background: Beneficial effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) against recurrent colorectal adenomas have been documented in systematic reviews; however, the results have not been conclusive. Uncertainty remains about the appropriate dose of aspirin for adenoma prevention. The persistence of the protective effect of NSAIDs against recurrent adenomas after treatment cessation is yet to be established. Read More

    Perioperative blood transfusion does not affect recurrence-free and overall survivals after curative resection for intrahepatic cholangiocarcinoma: a propensity score matching analysis.
    BMC Cancer 2017 Nov 14;17(1):762. Epub 2017 Nov 14.
    Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180 FengLin Road, Shanghai, 200032, China.
    Background: Whether perioperative blood transfusions (PBTs) adversely influence oncological outcomes for intrahepatic cholangiocarcinoma (ICC) patients after curative resection remains undetermined.

    Methods: Of the 605 patients who underwent curative liver resection for ICC between 2000 and 2012, 93 received PBT. We conducted Cox regression and variable selection logistic regression analyses to identify confounding factors of PBT. Read More

    Meta-analysis comparing laparoscopic versus open resection for gastric gastrointestinal stromal tumors larger than 5 cm.
    BMC Cancer 2017 Nov 13;17(1):760. Epub 2017 Nov 13.
    Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, 127 West Changle Road, 710032, Xi'an, Shaanxi, China.
    Background: Data on the safety and feasibility of laparoscopic versus open resection for gastric gastrointestinal stromal tumors (GISTs) larger than 5 cm are limited. Therefore, the aim of this meta-analysis was to compared laparoscopic and open resection for gastric GISTs larger than 5 cm.

    Methods: We perform a literature search on PubMed, the Cochrane Library, and Embase. Read More

    Diet and endometrial cancer: a focus on the role of fruit and vegetable intake, Mediterranean diet and dietary inflammatory index in the endometrial cancer risk.
    BMC Cancer 2017 Nov 13;17(1):757. Epub 2017 Nov 13.
    Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and University of Turin, Via Santena 7, Turin, Italy.
    Background: Endometrial cancer is the fourth most common cancer in European women. The major risk factors for endometrial cancer are related to the exposure of endometrium to estrogens not opposed to progestogens, that can lead to a chronic endometrial inflammation. Diet may play a role in cancer risk by modulating chronic inflammation. Read More

    Gene expression signatures of neuroendocrine prostate cancer and primary small cell prostatic carcinoma.
    BMC Cancer 2017 Nov 13;17(1):759. Epub 2017 Nov 13.
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Background: Neuroendocrine prostate cancer (NEPC) may be rising in prevalence as patients with advanced prostate cancer potentially develop resistance to contemporary anti-androgen treatment through a neuroendocrine phenotype. While prior studies comparing NEPC and prostatic adenocarcinoma have identified important candidates for targeted therapy, most have relied on few NEPC patients due to disease rarity, resulting in thousands of differentially expressed genes collectively and offering an opportunity for meta-analysis. Moreover, past studies have focused on prototypical NEPC samples with classic immunohistochemistry profiles, whereas there is increasing recognition of atypical phenotypes. Read More

    Oestrogen receptor beta isoform expression in sporadic colorectal cancer, familial adenomatous polyposis and progressive stages of colorectal cancer.
    BMC Cancer 2017 Nov 13;17(1):754. Epub 2017 Nov 13.
    Colorectal Tumor Nucleus of the Pelvic Surgery Department, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
    Background: Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP) syndrome and sporadic colorectal carcinomas are poorly described.

    Methods: This study aimed to investigate the expression levels of the ERβ1, ERβ2, ERβ4 and ERβ5 isoform variants using quantitative RT-PCR (921 analyses) in FAP, normal mucosa, adenomatous polyps and sporadic colorectal carcinomas. Read More

    The association of polymorphic markers Arg399Gln of XRCC1 gene, Arg72Pro of TP53 gene and T309G of MDM2 gene with breast cancer in Kyrgyz females.
    BMC Cancer 2017 Nov 13;17(1):758. Epub 2017 Nov 13.
    , Institute of Molecular Biology and Medicine, 3 Togolok Moldo Str, 720040, Bishkek, Kyrgyzstan.
    Background: The association of genes XRCC1, TP53 and MDM2 with breast cancer (BC) has never been tested in Kyrgyz population. We, therefore, aimed to identify an association of alleles and genotypes of polymorphic markers Arg399Gln of gene XRCC1, Arg72Pro of gene TP53, and T309G of gene MDM2 with the risk of BC in Kyrgyz women.

    Methods: This was a case-control study of 219 women of Kyrgyz origin with morphologically verified BC (N = 117) and 102 controls, age-matched with BC cases. Read More

    Association between gene expression profile of the primary tumor and chemotherapy response of metastatic breast cancer.
    BMC Cancer 2017 Nov 13;17(1):755. Epub 2017 Nov 13.
    Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, Netherlands.
    Background: To better predict the likelihood of response to chemotherapy, we have conducted a study comparing the gene expression patterns of primary tumours with their corresponding response to systemic chemotherapy in the metastatic setting.

    Methods: mRNA expression profiles of breast carcinomas of patients that later developed distant metastases were analyzed using supervised and non-supervised classification techniques to identify predictors of response to chemotherapy. The top differentially expressed genes between the responders and non-responders were identified and further explored. Read More

    CAISMOV24, a new human low-grade serous ovarian carcinoma cell line.
    BMC Cancer 2017 Nov 13;17(1):756. Epub 2017 Nov 13.
    Faculdade de Ciências Médicas, University of Campinas, Campinas, SP, Brazil.
    Background: The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma.

    Methods: The in vitro culture was established with cells isolated from ascites of a 60-year-old female patient with recurrent ovarian cancer. Read More

    Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma.
    BMC Cancer 2017 Nov 13;17(1):761. Epub 2017 Nov 13.
    Department of Bioinformatics & Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA.
    Background: Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. Read More

    Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors.
    BMC Cancer 2017 Nov 10;17(1):751. Epub 2017 Nov 10.
    Research Centre, Sainte-Justine University Health Center, 3175 chemin de la Côte-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada.
    Background: While cure rates for childhood acute lymphoblastic leukemia (cALL) now exceed 80%, over 60% of survivors will face treatment-related long-term sequelae, including cardiometabolic complications such as obesity, insulin resistance, dyslipidemia and hypertension. Although genetic susceptibility contributes to the development of these problems, there are very few studies that have so far addressed this issue in a cALL survivorship context.

    Methods: In this study, we aimed at evaluating the associations between common and rare genetic variants and long-term cardiometabolic complications in survivors of cALL. Read More

    TP53 Arg72 as a favorable prognostic factor for Chinese diffuse large B-cell lymphoma patients treated with CHOP.
    BMC Cancer 2017 Nov 10;17(1):743. Epub 2017 Nov 10.
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China.
    Background: TP53 Arg72Pro (SNP rs1042522) is associated with risk of non-Hodgkin lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of NHL. However, the relationship between this SNP and prognosis of DLBCL in Asians is unknown. Read More

    The preoperative neutrophil to lymphocyte ratio is a superior indicator of prognosis compared with other inflammatory biomarkers in resectable colorectal cancer.
    BMC Cancer 2017 Nov 10;17(1):744. Epub 2017 Nov 10.
    Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City, 110001, People's Republic of China.
    Background: Growing evidence has indicated that some inflammatory markers, including lymphocyte to monocyte ratio (LMR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and prognostic nutritional index (PNI), can be used as indicators in the prognosis of colorectal cancer (CRC). However, there is controversy concerning what is the best predictor of prognosis in CRC.

    Methods: A cohort of 1744 CRC patients in our institution was analyzed retrospectively. Read More

    Feasibility of structured endurance training and Mediterranean diet in BRCA1 and BRCA2 mutation carriers - an interventional randomized controlled multicenter trial (LIBRE-1).
    BMC Cancer 2017 Nov 10;17(1):752. Epub 2017 Nov 10.
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.
    Background: Women with pathogenic BRCA germline mutations have an increased risk for breast and ovarian cancer that seems to be modified by life-style factors. Though, randomized trials investigating the impact of lifestyle interventions on cancer prevention and prognosis in BRCA carriers are still missing.

    Methods: We implemented a multicenter, prospective randomized controlled trial in BRCA1/2 patients, comparing a lifestyle intervention group (IG) with a control group (CG) with the primary aim to prove feasibility. Read More

    Contrast-enhanced ultrasound of small cell carcinoma in urinary bladder: a case report and review of literature.
    BMC Cancer 2017 Nov 10;17(1):746. Epub 2017 Nov 10.
    Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
    Background: Small cell carcinoma of the urinary bladder (SCCB) is a relatively rare malignant bladder tumor, and few reports have investigated the microvasculature of SCCB imaged using contrast-enhanced ultrasound (CEUS).

    Case Presentation: A 63-year-old female was admitted to our hospital after experiencing painless gross hematuria for one week. The gray-scale ultrasound (US) demonstrated a 4. Read More

    miR-17-5p suppresses cell proliferation and invasion by targeting ETV1 in triple-negative breast cancer.
    BMC Cancer 2017 Nov 10;17(1):745. Epub 2017 Nov 10.
    Laboratory of Department of Surgery, First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Rd II, Guangzhou, Guangdong, 510080, People's Republic of China.
    Background: Triple-negative breast cancer (TNBC) is the malignancy with the worst outcome among all breast cancer subtypes. We reported that ETV1 is a significant oncogene in TNBC tumourigenesis. Consequently, investigating the critical regulatory microRNAs (miRNAs) of ETV1 may be beneficial for TNBC targeted therapy. Read More

    MicroRNA-195 acts as an anti-proliferative miRNA in human melanoma cells by targeting Prohibitin 1.
    BMC Cancer 2017 Nov 10;17(1):750. Epub 2017 Nov 10.
    The University of Texas Health Science Center at San Antonio, Children's Cancer Research Institute, 7703 Floyd Curl Drive, San Antonio, TX, 78229-390, USA.
    Background: Melanoma is the most lethal type of skin cancer. Since chemoresistance is a significant barrier, identification of regulators affecting chemosensitivity is necessary in order to create new forms of intervention. Prohibitin 1 (PHB1) can act as anti-apoptotic or tumor suppressor molecule, depending on its subcellular localization. Read More

    Safety and efficacy of abiraterone acetate in chemotherapy-naive patients with metastatic castration-resistant prostate cancer: an Italian multicenter "real life" study.
    BMC Cancer 2017 Nov 10;17(1):753. Epub 2017 Nov 10.
    Department of Urology, ASL Abruzzo2, Via dei Vestini, Chieti, Italy.
    Background: To evaluate the safety and efficacy of abiraterone acetate (AA) in the "real life" clinical practice for men with chemotherapy-naïve metastatic castration-resistant prostate.

    Methods: A consecutive series of patients with mCRPC in 9 Italian tertiary centres treated with AA was collected. Demographics, clinical parameters, treatment outcomes and toxicity were recorded. Read More

    YRNA expression predicts survival in bladder cancer patients.
    BMC Cancer 2017 Nov 10;17(1):749. Epub 2017 Nov 10.
    Department of Urology, University Hospital Bonn, Bonn, Germany.
    Background: Non-coding RNAs play an important role in human carcinogenesis. YRNAs (Ro-associated Y), a novel class of non-coding RNAs, have been identified as biomarker in various malignancies, but remain to be studied in urinary bladder cancer (BCA) patients.

    Methods: The expression of all four YRNAs (RNY1, RNY3, RNY4, RNY5) was determined in archival BCA (urothelial carcinoma, n = 88) and normal urothelial bladder (n = 30) tissues using quantitative real-time PCR. Read More

    Thoracoscopic and hand assisted laparoscopic esophagectomy with radical lymph node dissection for esophageal squamous cell carcinoma in the left lateral decubitus position: a single center retrospective analysis of 654 patients.
    BMC Cancer 2017 Nov 10;17(1):748. Epub 2017 Nov 10.
    Department of Surgery, Division of Gastroenterological and General Surgery, School of Medicine, Showa University, 142-8666, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.
    Background: The rates of thoracoscopic esophagectomy performed in the prone and left lateral decubitus positions are similar in Japan. We retrospectively reviewed short- and long-term outcomes of thoracoscopic esophagectomy for esophageal cancer performed in the left lateral decubitus position.

    Methods: Between 1996 and 2015, 654 patients with esophageal cancer underwent thoracoscopic esophagectomy in the left lateral decubitus position. Read More

    Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis.
    BMC Cancer 2017 Nov 10;17(1):747. Epub 2017 Nov 10.
    Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Medical School, Nottingham, NG7 2UH, UK.
    Background: Breast cancer patients are at an increased risk of venous thromboembolism (VTE). However, current evidence as to whether VTE increases the risk of mortality in breast cancer patients is conflicting. We present data from a large cohort of patients from the UK and pool these with previous data from a systematic review. Read More

    Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing.
    BMC Cancer 2017 Nov 9;17(1):738. Epub 2017 Nov 9.
    Biomarkers Research Program, Riyadh Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
    Background: Altered expression of receptor tyrosine kinases (RTKs) is a major driver of growth and metastasis of cancers. Recepteur d'origine nantais (RON) receptor is a single-pass transmembrane RTK aberrantly expressed in a number of cancers. Efforts to block deregulated RON signaling in tumors using small molecule kinase inhibitors or antibodies are complicated by the presence of unknown number/types of isoforms of RON, which, despite having similar sequences, are localized differently and mediate varied functions. Read More

    RAM score is an effective predictor for early mortality and recurrence after hepatectomy for hepatocellular carcinoma.
    BMC Cancer 2017 Nov 9;17(1):742. Epub 2017 Nov 9.
    Department of Surgery, Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan, Republic of China.
    Background: Liver resection had been regarded as a standard treatment for primary hepatocellular carcinoma (HCC). However, early mortality and recurrence after surgery were still of major concern. RAM (Risk Assessment for early Mortality) scoring system is a newly developed tool for assessing early mortality after hepatectomy for HCC. Read More

    Prevalence and associated factors of medication non-adherence in hematological-oncological patients in their home situation.
    BMC Cancer 2017 Nov 9;17(1):739. Epub 2017 Nov 9.
    Emma Children's Hospital, Academic Medical Center, Amsterdam, the Netherlands.
    Background: Medication non-adherence is associated with poor health outcomes and increased health care costs. Depending on definitions, reported non-adherence rates in cancer patients ranges between 16 and 100%, which illustrates a serious problem. In malignancy, non-adherence reduces chances of achievement of treatment response and may thereby lead to progression or even relapse. Read More

    Optimal interval of endoscopic screening based on stage distributions of detected gastric cancers.
    BMC Cancer 2017 Nov 9;17(1):740. Epub 2017 Nov 9.
    Committee of Gastrointestinal Cancer Screening, Niigata City Medical Association, 3-3-1 Shichikuyama Chuo-ku, Niigata, 950-0914, Japan.
    Background: Although Korea and Japan have a national gastric cancer screening program, their screening intervals are different. The optimal screening interval of endoscopic screening in Japan was investigated based on the stage distributions of screen-detected gastric cancers.

    Methods: Patients with gastric cancer detected by endoscopic and radiographic screenings were selected from the Niigata City Medical Association database. Read More

    Comparison of different therapeutic strategies for complete hydatidiform mole in women at least 40 years old: a retrospective cohort study.
    BMC Cancer 2017 Nov 9;17(1):733. Epub 2017 Nov 9.
    Department of Gynaecologic Oncology, Women's hospital, School of Medicine, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang Province, China.
    Background: There are three main therapeutic strategies, namely expectant management (dilation and curettage only), prophylactic chemotherapy and prophylactic total hysterectomy for treating older women with complete hydatidiform mole (CHM). However, the scientific community has so far, not unanimously accepted the above-mentioned methods. The objective of this study was to evaluate the effectiveness of these therapeutic strategies in preventing post-molar gestational trophoblastic neoplasia (GTN) pertaining to patients with CHM who were at least 40 years old. Read More

    Perceived stigmatization and its impact on quality of life - results from a large register-based study including breast, colon, prostate and lung cancer patients.
    BMC Cancer 2017 Nov 9;17(1):741. Epub 2017 Nov 9.
    Department of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, D - 04103, Leipzig, Germany.
    Background: To date, research on stigmatization among cancer patients and related psychosocial consequences has been scarce and mostly based on small and highly selected samples. We investigated stigmatization and its impact on quality of life among a large sample including four major tumor entities.

    Methods: We assessed 858 patients with breast, colon, lung or prostate cancer from two cancer registries. Read More

    Barriers to HPV self-sampling and cytology among low-income indigenous women in rural areas of a middle-income setting: a qualitative study.
    BMC Cancer 2017 Nov 9;17(1):734. Epub 2017 Nov 9.
    Center for Population Health Research, National Institute of Public Health, Av. Universidad #655, Colonia Sta. Ma. Ahuacatitlán, 62508, Cuernavaca, Morelos, Mexico.
    Background: Data is needed about barriers to self-collection of Human Papillomavirus (HPV) samples and cytology among low-income, disadvantaged women living in rural areas of lower-income countries as these women are at increased risk of cervical cancer mortality.

    Methods: Individual interviews (n = 29), focus groups (n = 7, 5-11 participants) and discussion groups (n = 2, 18-25 participants) were organized with women from three indigenous ethnic groups residing in rural areas in Mexico, after they were provided with free, self-sampled HPV tests. These groups are low-income, underserved by healthcare and have historically been on the receiving end of racism and social exclusion. Read More

    Diagnostic and prognostic value of CEA, CA19-9, AFP and CA125 for early gastric cancer.
    BMC Cancer 2017 Nov 9;17(1):737. Epub 2017 Nov 9.
    Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University, 127 West Changle Road, 710032, , Xian, Shaanxi, China.
    Background: The diagnostic and prognostic significance of carcinoembryonic antigen (CEA), carbohydrate associated antigen 19-9 (CA19-9), alpha-fetoprotein (AFP) and cancer antigen 125 (CA125) in early gastric cancer have not been investigated yet. Thus, the present study aimed to explore the diagnostic and prognostic significance of the four tumor markers for early gastric cancer.

    Methods: From September 2008 to March 2015, 587 early gastric cancer patients were given radical gastrectomy in our center. Read More

    Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas.
    BMC Cancer 2017 Nov 9;17(1):736. Epub 2017 Nov 9.
    Molecular and Cellular Biology Program, OSU, Corvallis, 97331, OR, USA.
    Background: Understanding the underlying molecular mechanisms involved in the formation of cutaneous malignant melanoma is critical for improved diagnosis and treatment. Keratinocytic nuclear receptor Retinoid X Receptor α (RXRα) has a protective role against melanomagenesis and is involved in the regulation of keratinocyte and melanocyte homeostasis subsequent acute ultraviolet (UV) irradiation.

    Methods: We generated a trigenic mouse model system (RXRα (ep-/-) | Tyr-NRAS (Q61K) | CDK4 (R24C/R24C) ) harboring an epidermal knockout of Retinoid X Receptor α (RXRα (ep-/-) ), combined with oncogenic NRAS (Q61K) (constitutively active RAS) and activated CDK4 (R24C/R24C) (constitutively active CDK4). Read More

    Successful pregnancy without disease progression of radioiodine refractory papillary thyroid carcinoma: a case report.
    BMC Cancer 2017 Nov 9;17(1):735. Epub 2017 Nov 9.
    Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Rd. 600, Shanghai, 200233, People's Republic of China.
    Background: Pregnancy is an unquantifiable risk to accelerate tumor growth of papillary thyroid carcinoma (PTC), and whether pregnancy induces an unfavorable prognosis of radioiodine refractory papillary thyroid carcinoma (RR-PTC) remains unknown.

    Case Presentation: We investigated the impact of pregnancy on the prognosis of pulmonary metastases in an RR-PTC woman via a long-term clinical follow-up and consecutive computed tomography examinations and serum tests. After a successful pregnancy, the metastatic lesions shrank with serum thyroglobulin slightly fluctuated under sustained thyroid stimulating hormone (TSH) suppression, demonstrating a favorable outcome. Read More

    Pneumatosis cystoides intestinalis associated with sunitinib and a literature review.
    BMC Cancer 2017 Nov 9;17(1):732. Epub 2017 Nov 9.
    Division of Medical Oncology-Hematology, Department of Internal Medicine, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, (02447) 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, South Korea.
    Background: Pneumatosis cystoides intestinalis (PCI) is a rare self-limiting condition characterized by air-filled cysts within intestinal walls. Diagnosis should be prudent because it can mimic pneumoperitoneum leading to unnecessary treatment such as surgical exploration. Although various drugs including anti-neoplastic agents have been suggested as etiologies, cases related to sunitinib are sparse. Read More

    Alterations in PGC1α expression levels are involved in colorectal cancer risk: a qualitative systematic review.
    BMC Cancer 2017 Nov 9;17(1):731. Epub 2017 Nov 9.
    Grupo de Investigación en Interacciones Gen-Ambiente y Salud, Universidad de León, León, Spain.
    Background: Colorectal cancer (CRC) is a major global public health problem and the second leading cause of cancer-related death. Mitochondrial dysfunction has long been suspected to be involved in this type of tumorigenesis, as supported by an accumulating body of research evidence. However, little is known about how mitochondrial alterations contribute to tumorigenesis. Read More

    Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients.
    BMC Cancer 2017 Nov 9;17(1):730. Epub 2017 Nov 9.
    Latvian Biomedical Research and Study Centre, Ratsupites Str 1, k-1, Riga, LV-1067, Latvia.
    Background: Circulating cell-free miRNAs have emerged as promising minimally-invasive biomarkers for early detection, prognosis and monitoring of cancer. They can exist in the bloodstream incorporated into extracellular vesicles (EVs) and ribonucleoprotein complexes. However, it is still debated if EVs contain biologically meaningful amounts of miRNAs and may provide a better source of miRNA biomarkers than whole plasma. Read More

    A novel chemotherapeutic sensitivity-testing system based on collagen gel droplet embedded 3D-culture methods for hepatocellular carcinoma.
    BMC Cancer 2017 Nov 8;17(1):729. Epub 2017 Nov 8.
    Research Center for Clinical and Translational Medicine, the 302nd Hospital of Chinese PLA, Beijing, 100039, People's Republic of China.
    Background: Patients suffering from advanced stage hepatocellular carcinoma (HCC) often exhibit a poor prognosis or dismal clinical outcomes due to ineffective chemotherapy or a multi-drug resistance (MDR) process. Thus, it is urgent to develop a new chemotherapeutic sensitivity testing system for HCC treatment. The presence study investigated the potential application of a novel chemotherapeutic sensitivity-testing system based on a collagen gel droplet embedded 3D-culture system (CD-DST). Read More

    Seropositivity to herpes simplex virus type 2, but not type 1 is associated with cervical cancer: NHANES (1999-2014).
    BMC Cancer 2017 Nov 7;17(1):726. Epub 2017 Nov 7.
    Laboratory of immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
    Background: Herpes simplex virus types 1 and 2 (HSV1 and HSV2) are infectious agents, and their association with cancer occurrence in human is a controversial topic for decades. We addressed this subject using all available continuous National Health and Nutrition Examination Survey (NHANES) cross-sectional data from 1999 to 2014.

    Methods: Eight data cycles (1999-2000, 2001-2002, 2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012, and 2013-2014) were employed, and a sample of 8184 female participants was used in this study according to the availability of cancer history and HSV serostatus. Read More

    microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer.
    BMC Cancer 2017 Nov 7;17(1):723. Epub 2017 Nov 7.
    Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
    Background: The aim of this study was to identify miRNAs specifically dysregulated in BRAF-mutated colorectal cancer, which could lead to a better understanding of the molecular mechanisms underlying oncogenesis of this malignant subtype of colorectal cancer.

    Methods: Candidate dysregulated miRNAs were selected in genome-wide miRNA expression array analysis using a screening set composed of 15 BRAF-mutated and 15 non-KRAS/BRAF-mutated colorectal cancers. The miRNA expressions were validated in another set of patients. Read More

    Does hair dye use really increase the risk of prostate cancer?
    BMC Cancer 2017 Nov 7;17(1):724. Epub 2017 Nov 7.
    Division of Basic Medical Research, Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386, Dajhong 1st Road, Zuoying District, Kaohsiung, 813, Taiwan.
    Recently, Shu-Yu Tai et al. reported that personal hair dye use increased risk of prostate cancer with a dose-response effect. Although hair dyes were identified as carcinogenic in animals and increased risk of some cancers among hairdressers, the existing epidemiological data did not support that personal hair dye use increased risk of cancers, even for bladder cancer. Read More

    Carbon ion radiotherapy for 80 years or older patients with hepatocellular carcinoma.
    BMC Cancer 2017 Nov 7;17(1):721. Epub 2017 Nov 7.
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Syowa-machi, Maebashi, Gunma, 371-8511, Japan.
    Background: To evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) for 80 years or older patients with hepatocellular carcinoma (HCC).

    Methods: Eligibility criteria of this retrospective study were: 1) HCC confirmed by histology or typical hallmarks of HCC by imaging techniques of four-phase multidetector-row computed tomography or dynamic contrast-enhanced magnetic resonance imaging; 2) no intrahepatic metastasis or distant metastasis; 3) no findings suggesting direct infiltration of the gastrointestinal tract; 4) performance status ≤2 by Eastern Cooperative Oncology Group classification; and 5) Child-Pugh classification A or B. Patients received C-ion RT with 52. Read More

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