11,139 results match your criteria BMC Cancer[Journal]


An isolated vaginal metastasis from intestinal signet ring cell carcinoma: a case report and literature review.

BMC Cancer 2020 May 27;20(1):478. Epub 2020 May 27.

The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Background: Isolated vaginal metastases from intestinal signet ring cell carcinoma are extremely rare. There are no reported cases in the domestic or foreign literature. The characteristics of such cases of metastasis remain relatively unknown. Read More

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http://dx.doi.org/10.1186/s12885-020-06950-xDOI Listing

Discrimination between clinical significant and insignificant prostate cancer with apparent diffusion coefficient - a systematic review and meta analysis.

BMC Cancer 2020 May 27;20(1):482. Epub 2020 May 27.

Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.

Background: Prostate MRI has become a corner stone in diagnosis of prostate cancer (PC). Diffusion weighted imaging and the apparent diffusion coefficient (ADC) can be used to reflect tumor microstructure. The present analysis sought to compare ADC values of clinically insignificant with clinical significant PC based upon a large patient sample. Read More

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http://dx.doi.org/10.1186/s12885-020-06942-xDOI Listing

Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with non small cell lung cancer: a multi-institutional national retrospective study.

BMC Cancer 2020 May 27;20(1):479. Epub 2020 May 27.

Research and investigation in medical oncology Moroccan group, Faculty of medicine and pharmacy, Mohammed V University, Impasse souissi, 10100, Rabat, Morocco.

Background: Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asians. However, data identifying the frequency of this rearrangement in Moroccan and North African population are lacking. Read More

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http://dx.doi.org/10.1186/s12885-020-06973-4DOI Listing

CYP19A1 gene expression in the peripheral blood of Brazilian women with breast cancer relapse.

BMC Cancer 2020 May 27;20(1):480. Epub 2020 May 27.

Postgraduate Program of the Northeast Network of Biotechnology (RENORBIO), Teresina, Northeast, Brazil.

Background: The CYP19A1 gene, which encodes the enzyme responsible for androgen aromatization into estrogens, may play an important role in breast cancer aggressiveness. However, no study has evaluated CYP19A1 gene expression in the peripheral blood of women with relapsed breast cancer.

Methods: In this cross-sectional study, CYP19A1 gene expression was quantified by RT-PCR in the peripheral blood of 146 women with breast cancer who were first divided into two groups according to the expression of CYP19A1 (low and high); each group had 73 patients. Read More

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http://dx.doi.org/10.1186/s12885-020-06978-zDOI Listing

Cancer staging in individuals with a severe psychiatric illness: a cross-sectional study using population-based cancer registry data.

BMC Cancer 2020 May 27;20(1):476. Epub 2020 May 27.

ICES, 2075 Bayview Ave, Toronto, ON, M4N 3M5, Canada.

Background: Advanced cancer stage at diagnosis may explain high cancer mortality among patients with a severe psychiatric illness (SPI). Studies to date investigating advanced stage cancer at diagnosis as a potential explanation for high cancer mortality in individuals with a history of mental illness have been inconclusive. We examined the relationship between a SPI history and unknown cancer stage at diagnosis in colorectal cancer (CRC) patients. Read More

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http://dx.doi.org/10.1186/s12885-020-06943-wDOI Listing

Knowledge, attitudes and practices of South Asian immigrants in developed countries regarding oral cancer: an integrative review.

BMC Cancer 2020 May 27;20(1):477. Epub 2020 May 27.

Centre for Oral Health Outcomes and Research Translation (COHORT), School of Nursing and Midwifery, Western Sydney University/South Western Sydney Local Health District / Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia.

Background: Oral cancer is a growing problem worldwide, with high incidence rates in South Asian countries. With increasing numbers of South Asian immigrants in developed countries, a possible rise in oral cancer cases is expected given the high prevalence in their source countries and the continued oral cancer risk behaviours of immigrants. The aim of this review is to synthesise existing evidence regarding knowledge, attitudes and practices of South Asian immigrants in developed countries regarding oral cancer. Read More

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http://dx.doi.org/10.1186/s12885-020-06944-9DOI Listing

The structural effect of high intensity ultrasound on peritoneal tissue: a potential vehicle for targeting peritoneal metastases.

BMC Cancer 2020 May 27;20(1):481. Epub 2020 May 27.

Division of Colorectal Surgery, Department of Surgery, University of California Irvine, California, 92868, USA.

Background: High-intensity ultrasound (HIUS) has been increasingly investigated as a possible tool in the treatment of multiple tumor entities. However, there is only little knowledge on the effect of HIUS on the peritoneum. This preliminary study aims to investigate HIUS' potential for altering the peritoneal surface and potentially improving current treatments for peritoneal metastases. Read More

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http://dx.doi.org/10.1186/s12885-020-06981-4DOI Listing

A novel pancreatic tumour and stellate cell 3D co-culture spheroid model.

BMC Cancer 2020 May 27;20(1):475. Epub 2020 May 27.

Pancreas Cancer Research Lab, Department of Clinical Intervention and Technology (CLINTEC), Karolinska Institutet, Novum, floor 6, room 613, SE-141 86, Stockholm, Sweden.

Background: Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and reproducible in vitro 3D-assay employing the main constituents of pancreatic ductal adenocarcinoma, namely pancreatic stellate and cancer cells.

Method: A spheroid assay, directly co-culturing human pancreatic stellate cells with human pancreatic tumour cells in 3D was established and characterized by electron microscopy, immunohistochemistry and real-time RT-PCR. Read More

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http://dx.doi.org/10.1186/s12885-020-06867-5DOI Listing

Damage-associated molecular patterns (DAMPs) related to immunogenic cell death are differentially triggered by clinically relevant chemotherapeutics in lung adenocarcinoma cells.

BMC Cancer 2020 May 26;20(1):474. Epub 2020 May 26.

Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Background: Chemotherapeutics can stimulate immune antitumor response by inducing immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns (DAMPs) like the exposure of calreticulin (CRT) on the cell surface, the release of ATP and the secretion of High Mobility Group Box 1 (HMGB1).

Methods: Here, we investigated the levels of ICD-associated DAMPs induced by chemotherapeutics commonly used in the clinical practice of non-small cell lung cancer (NSCLC) and the association of these DAMPs with apoptosis and autophagy. A549 human lung adenocarcinoma cells were treated with clinically relevant doses of cisplatin, carboplatin, etoposide, paclitaxel and gemcitabine. Read More

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http://dx.doi.org/10.1186/s12885-020-06964-5DOI Listing

Elderly women's experiences of self-sampling for HPV testing.

BMC Cancer 2020 May 26;20(1):473. Epub 2020 May 26.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Background: Self-sampling for HPV testing, as an alternative to the conventional speculum based sampling, is highly acceptable to women of screening ages. The aim of this study was to describe older women's (60 to 75 years) experiences of self-sampling.

Methods: In Sweden a descriptive study with quantitative and qualitative methods was designed to collect data from a survey of women who participated in self-sampling for HPV testing. Read More

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http://dx.doi.org/10.1186/s12885-020-06977-0DOI Listing

Hyperfunction of CD4 CD25 regulatory T cells in de novo acute myeloid leukemia.

BMC Cancer 2020 May 26;20(1):472. Epub 2020 May 26.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 288, Nanjing Road, Tianjin, 300020, China.

Background: Acute myeloid leukemia (AML) is a common hematopoietic malignancy that has a high relapse rate, and the number of regulatory T cells (Tregs) in AML patients is significantly increased. The aim of this study was to clarify the role of Tregs in the immune escape of acute myeloid leukemia.

Methods: The frequencies of Tregs and the expression of PD-1, CXCR4 and CXCR7 were examined by flow cytometry. Read More

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http://dx.doi.org/10.1186/s12885-020-06961-8DOI Listing

The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis.

BMC Cancer 2020 May 26;20(1):471. Epub 2020 May 26.

Department of Clinical Laboratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.

Background: Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the metabolism of tryptophan into kynurenine. It is considered to be an immunosuppressive molecule that plays an important role in the development of tumors. However, the association between IDO and solid tumor prognosis remains unclear. Read More

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http://dx.doi.org/10.1186/s12885-020-06956-5DOI Listing

CT-based radiomics scores predict response to neoadjuvant chemotherapy and survival in patients with gastric cancer.

BMC Cancer 2020 May 25;20(1):468. Epub 2020 May 25.

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Road 2, Guangzhou, 510080, People's Republic of China.

Background: Neoadjuvant chemotherapy is a promising treatment option for potential resectable gastric cancer, but patients' responses vary. We aimed to develop and validate a radiomics score (rad_score) to predict treatment response to neoadjuvant chemotherapy and to investigate its efficacy in survival stratification.

Methods: A total of 106 patients with neoadjuvant chemotherapy before gastrectomy were included (training cohort: n = 74; validation cohort: n = 32). Read More

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http://dx.doi.org/10.1186/s12885-020-06970-7DOI Listing

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer.

BMC Cancer 2020 May 25;20(1):470. Epub 2020 May 25.

Auckland Cancer Society Research Centre, School of Medical Sciences, Faculty of Medical and Health Sciences University of Auckland, Private Bag, Auckland, 92019, New Zealand.

Background: Glutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is converted to glutamate in a reaction catalysed by mitochondrial glutaminase. This glutamate has many uses, including acting as an anaplerotic substrate (via alpha-ketoglutarate) to replenish TCA cycle intermediates. Read More

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http://dx.doi.org/10.1186/s12885-020-06885-3DOI Listing

Independence of HIF1a and androgen signaling pathways in prostate cancer.

BMC Cancer 2020 May 25;20(1):469. Epub 2020 May 25.

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, OX3 9DU, UK.

Background: Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progression to castrate-resistant prostate cancer (CRPC). Hypoxia and HIF1a have been implicated in the development of resistance to androgen targeted therapies and progression to CRCP. Read More

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http://dx.doi.org/10.1186/s12885-020-06890-6DOI Listing

Cancer risks in Lynch syndrome, Lynch-like syndrome, and familial colorectal cancer type X: a prospective cohort study.

BMC Cancer 2020 May 24;20(1):460. Epub 2020 May 24.

Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany.

Background: Individuals with pathogenic germline variants in DNA mismatch repair (MMR) genes are at increased risk of developing colorectal, endometrial and other cancers (Lynch syndrome, LS). While previous studies have extensively described cancer risks in LS, cancer risks in individuals from families without detectable MMR gene defects despite MMR deficiency (Lynch-like syndrome, LLS), and in individuals from families fulfilling the Amsterdam-II criteria without any signs of MMR deficiency (familial colorectal cancer type X, FCCX) are less well studied. The aim of this prospective study was to characterise the risk for different cancer types in LS, LLS, and FCCX, and to compare these with the cancer risks in the general population. Read More

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http://dx.doi.org/10.1186/s12885-020-06926-xDOI Listing

A novel risk score model based on eight genes and a nomogram for predicting overall survival of patients with osteosarcoma.

BMC Cancer 2020 May 24;20(1):456. Epub 2020 May 24.

Departments of Orthopedics, The Third Hospital of Jilin University, Changchun, Jilin Province, China.

Background: This study aims to identify a predictive model to predict survival outcomes of osteosarcoma (OS) patients.

Methods: A RNA sequencing dataset (the training set) and a microarray dataset (the validation set) were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database, respectively. Differentially expressed genes (DEGs) between metastatic and non-metastatic OS samples were identified in training set. Read More

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http://dx.doi.org/10.1186/s12885-020-06741-4DOI Listing

Achieving objective response in treatment of non-resectable neuroendocrine tumors does not predict longer time to progression compared to achieving stable disease.

BMC Cancer 2020 May 24;20(1):466. Epub 2020 May 24.

Center for neuroendocrine tumors, Department of Gastroenterology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0424, Oslo, Norway.

Background: There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasis has been put on inducing the tumors to stop growing without a reduction in total tumor load; termed as stable disease (SD). Read More

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http://dx.doi.org/10.1186/s12885-020-06963-6DOI Listing

Could venous thromboembolism and major bleeding be indicators of lung cancer mortality? A nationwide database study.

BMC Cancer 2020 May 24;20(1):461. Epub 2020 May 24.

Biostatistics and Bioinformatics (DIM), University Hospital, Bourgogne Franche-Comté University, Dijon, France.

Background: Venous thromboembolism (VTE) is highly prevalent in cancer patients and can cause severe morbidity. VTE treatment is essential, but anticoagulation increases the risk of major bleeding. The purpose was to evaluate the impact of VTE and major bleeding on survival and to identify significant risk factors for these events in lung cancer patients. Read More

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http://dx.doi.org/10.1186/s12885-020-06930-1DOI Listing

Comparison of Tc-MIBI scintigraphy, ultrasound, and mammography for the diagnosis of BI-RADS 4 category lesions.

BMC Cancer 2020 May 24;20(1):463. Epub 2020 May 24.

Department of Nuclear Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, China.

Background: We sought to determine the diagnostic efficacy of Breast-specific gamma imaging (BSGI) in Chinese women with BI-RADS 4 category lesions and to compare this efficacy to that of ultrasound/mammography.

Methods: We retrospectively analyzed data from 177 women that had undergone BSGI of BI-RADS 4 category lesions originally detected via ultrasound and/or mammography.

Results: Of these 177 cases, 117 (66. Read More

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http://dx.doi.org/10.1186/s12885-020-06938-7DOI Listing

Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.

BMC Cancer 2020 May 24;20(1):467. Epub 2020 May 24.

Department of Obstetrics and Gynecology, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.

Background: The mitochondrial fission protein, Dynamin related protein 1 (Drp1), and its upstream protein calcium/calmodulin-dependent protein kinase I (CaMKI) play a critical role in chemoresistance in ovarian cancer (OVCA). Thus, we examined the expression of Drp1, CaMKI and their phosphorylated forms and their prognostic impact in epithelial OVCA patients.

Methods: Expression analysis was performed by immunohistochemistry (IHC) of paraffin-embedded tumor samples from 49 patients with epithelial OVCA. Read More

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http://dx.doi.org/10.1186/s12885-020-06965-4DOI Listing

Combination of preoperative neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio: a superior prognostic factor of endometrial cancer.

BMC Cancer 2020 May 24;20(1):464. Epub 2020 May 24.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Sanhao Street, 110004, Shenyang, People's Republic of China.

Background: The preoperative peripheral blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR) have been reported to be associated with the prognosis of various cancers but are always discussed separately. The aim of this study is to bring the combination of NLR, PLR and MLR into the prognostic assessment system of endometrial cancer (EC) and establish a nomogram to provide an objective prediction model for clinical decisions.

Methods: A total of 1111 patients with EC who had accepted surgical treatment during 2013-2017 were involved in the analysis. Read More

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http://dx.doi.org/10.1186/s12885-020-06953-8DOI Listing

Experiences and views of different key stakeholders on the feasibility of treating cancer-related fatigue.

BMC Cancer 2020 May 24;20(1):458. Epub 2020 May 24.

Institute for Complementary and Integrative Medicine, University Hospital Zurich and University of Zurich, Sonneggstrasse 6, 8091, Zurich, Switzerland.

Background: Although cancer-related fatigue (CRF) has gained increased attention in the past decade, therapy remains a challenge. Treatment programs are more likely to be effective if the needs and interests of the persons involved are well represented. This can be achieved by stakeholder engagement. Read More

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http://dx.doi.org/10.1186/s12885-020-06858-6DOI Listing

Text mining in a literature review of urothelial cancer using topic model.

BMC Cancer 2020 May 24;20(1):462. Epub 2020 May 24.

Division of Nephrology, Asia University Hospital, Taichung, Taiwan.

Background: Urothelial cancer (UC) includes carcinomas of the bladder, ureters, and renal pelvis. New treatments and biomarkers of UC emerged in this decade. To identify the key information in a vast amount of literature can be challenging. Read More

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http://dx.doi.org/10.1186/s12885-020-06931-0DOI Listing

Metastasis-directed therapy in castration-refractory prostate cancer (MEDCARE): a non-randomized phase 2 trial.

BMC Cancer 2020 May 24;20(1):457. Epub 2020 May 24.

Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.

Background: Patients diagnosed with metastatic castration-refractory prostate cancer (mCRPC) rely on a limited number of therapeutic agents resulting in a median survival of 2-3 years. A subgroup of those patients with mCRPC presents with oligoprogressive disease, with a limited number of progressive lesions while other metastases are still controlled by ongoing systemic treatment.

Methods: In this single arm prospective phase II trial, we aim to include 18 patients with oligoprogressive mCRPC (1-3 metastases and/or local recurrence) who will be treated with metastasis-directed therapy to all visible progressive lesions. Read More

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http://dx.doi.org/10.1186/s12885-020-06853-xDOI Listing

LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer.

BMC Cancer 2020 May 24;20(1):459. Epub 2020 May 24.

Department of Radiation Sciences, Oncology, Umeå University, SE-90187, Umeå, Sweden.

Background: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) copy number alterations and unbalanced gene recombination events have been reported to occur in breast cancer. Importantly, LRIG1 loss was recently shown to predict early and late relapse in stage I-II breast cancer.

Methods: We developed droplet digital PCR (ddPCR) assays for the determination of relative LRIG1 copy numbers and used these assays to analyze LRIG1 in twelve healthy individuals, 34 breast tumor samples previously analyzed by fluorescence in situ hybridization (FISH), and 423 breast tumor cytosols. Read More

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http://dx.doi.org/10.1186/s12885-020-06919-wDOI Listing

Association of Helicobacter pylori babA2 gene and gastric cancer risk: a meta-analysis.

BMC Cancer 2020 May 24;20(1):465. Epub 2020 May 24.

Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.

Background: The association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relationship between H. Read More

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http://dx.doi.org/10.1186/s12885-020-06962-7DOI Listing

The introduction of risk stratified screening into the NHS breast screening Programme: views from British-Pakistani women.

BMC Cancer 2020 May 20;20(1):452. Epub 2020 May 20.

Nightingale & Prevent Breast Cancer Research Unit, Manchester University NHS Foundation Trust (MFT), Southmoor Road, Wythenshawe, Manchester, M23 9LT, UK.

Background: UK national guidelines suggest women at high-risk of breast cancer should be offered more frequent screening or preventative medications. Currently, only 1 in 6 high-risk women are identified. One route to identify more high-risk women is via multifactorial risk assessment as part of the UK's NHS Breast Screening Programme (NHSBSP). Read More

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http://dx.doi.org/10.1186/s12885-020-06959-2DOI Listing

Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up.

BMC Cancer 2020 May 20;20(1):453. Epub 2020 May 20.

University of Eastern Finland, Kuopio, Finland.

Background: As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an additional risk factor for cancer development and the SPCs appearing beyond 5 years after radiotherapy in the original treatment field can be considered as radiation-induced subsequent primary cancers (RISPCs).

Methods: During the years 1999-2008, 241 patients with localized PCa who underwent low dose-rate brachytherapy (LDR-BT) with I125 and were followed-up in Kuopio University Hospital, were included in this study. Read More

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http://dx.doi.org/10.1186/s12885-020-06960-9DOI Listing

The clinical significance of the T2-FLAIR mismatch sign in grade II and III gliomas: a population-based study.

BMC Cancer 2020 May 20;20(1):450. Epub 2020 May 20.

Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: The T2-FLAIR mismatch sign is an imaging finding highly suggestive of isocitrate dehydrogenase mutated (IDH-mut) 1p19q non-codeleted (non-codel) gliomas (astrocytomas). In previous studies, it has shown excellent specificity but limited sensitivity for IDH-mut astrocytomas. Whether the mismatch sign is a marker of a clinically relevant subtype of IDH-mut astrocytomas is unknown. Read More

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http://dx.doi.org/10.1186/s12885-020-06951-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238512PMC

Modified FOLFIRINOX as a second-line therapy following gemcitabine plus nab-paclitaxel therapy in metastatic pancreatic cancer.

BMC Cancer 2020 May 20;20(1):449. Epub 2020 May 20.

Division of Hepato-Biliary-Pancreatic Medicine, Department of Gastroenterology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto, Tokyo, 135-8550, Japan.

Background: There is no established second-line treatment after failure of gemcitabine plus nab-paclitaxel (GnP) therapy for metastatic pancreatic cancer (MPC). The purpose of this study was to evaluate the efficacy and tolerability of the modified FOLFIRINOX (mFFX) as a second-line therapy for MPC and to investigate prognostic factors for survival.

Methods: From 2015 to 2019, we retrospectively reviewed the medical records of consecutive patients receiving mFFX for MPC after failure of GnP therapy. Read More

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http://dx.doi.org/10.1186/s12885-020-06945-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238500PMC

Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy.

BMC Cancer 2020 May 20;20(1):451. Epub 2020 May 20.

Comprehensive Breast Cancer Center, Changhua Christian Hospital, 135, Nanhsiao Street, Changhua, 500209, Taiwan.

Background: The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margin status and locoregional recurrence (LRR).

Methods: Our institutional prospectively maintained database was reviewed to identify patients who were treated with NACT between January 2008 and April 2018.

Results: Among the main partial mastectomy specimens available for analysis (n = 161), 28 had margins < 1 mm, 21 had margin width of 1-2 mm and the remaining 112 had margins > 2 mm. Read More

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http://dx.doi.org/10.1186/s12885-020-06955-6DOI Listing

Insight into bladder cancer care: study protocol of a large nationwide prospective cohort study (BlaZIB).

BMC Cancer 2020 May 20;20(1):455. Epub 2020 May 20.

Department of Research and Development, Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.

Background: Despite the embedding of bladder cancer management in European guidelines, large variation in clinical practice exists for applied diagnostics and treatments. This variation may affect patients' outcomes including complications, disease recurrence, progression, survival, and health-related quality of life (HRQL). Lack of detailed clinical data and HRQL data hampers a comprehensive evaluation of bladder cancer care. Read More

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http://dx.doi.org/10.1186/s12885-020-06954-7DOI Listing

Tumor-associated tissue eosinophilia predicts favorable clinical outcome in solid tumors: a meta-analysis.

BMC Cancer 2020 May 20;20(1):454. Epub 2020 May 20.

Department of Gynecology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Background: Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TATE) in human cancers remains controversial. Therefore, we conducted this meta-analysis to better comprehend the association between TATE and clinical outcomes of patients. Read More

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http://dx.doi.org/10.1186/s12885-020-06966-3DOI Listing

Comparison of hybrid clones derived from human breast epithelial cells and three different cancer cell lines regarding in vitro cancer stem/ initiating cell properties.

BMC Cancer 2020 May 19;20(1):446. Epub 2020 May 19.

Institute of Immunology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Str. 10, 58448, Witten, Germany.

Background: Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion. In cancer it was postulated that the fusion of cancer cells with normal cells such as macrophages or stem cells may not only give rise to hybrid cells exhibiting novel properties, such as an increased metastatic capacity and drug resistance, but possibly also cancer stem/ initiating cell properties. Hence, hybrid clone cells (M13HS, M13MDA435 and M13MDA231) that were derived from spontaneous fusion events of human M13SV1-EGFP-Neo breast epithelial cells and HS578T-Hyg, MDA-MB-435-Hyg and MDA-MB-231-Hyg cancer cells were investigated regarding potential in vitro cancer stem/ initiating cell properties. Read More

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http://dx.doi.org/10.1186/s12885-020-06952-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236176PMC

Stereotactic body radiotherapy (SBRT) in patients with lung metastases - prognostic factors and long-term survival using patient self-reported outcome (PRO).

BMC Cancer 2020 May 19;20(1):442. Epub 2020 May 19.

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich (TUM), Ismaninger Straße 22, 81675, Munich, Germany.

Objectives: The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the investigated data from patient charts and patient-reported outcome (PRO) up to 14 years after therapy.

Materials And Methods: We analyzed 219 patients and 316 lung metastases treated between 2004 and 2019. Read More

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http://dx.doi.org/10.1186/s12885-020-6635-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236290PMC

Prognostic and diagnostic value of circRNA expression in colorectal carcinoma: a meta-analysis.

BMC Cancer 2020 May 19;20(1):448. Epub 2020 May 19.

Department of Gastrointestinal Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Background: Circular RNAs (circRNAs) are research hotspots in the network of noncoding RNAs in numerous tumours. The purpose of our study was to evaluate the clinicopathological, prognostic and diagnostic value of circRNAs in colorectal cancer.

Methods: The PubMed, Cochrane Library, and Web of Science online databases were searched for relevant studies before May 15, 2019. Read More

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http://dx.doi.org/10.1186/s12885-020-06932-zDOI Listing

Multiple HPV 16 infection with two strains: a possible marker of neoplastic progression.

BMC Cancer 2020 May 19;20(1):444. Epub 2020 May 19.

Department of General Surgery and Medical Surgery Specialties, Gynecological Clinic, University of Catania, Catania, Italy.

Background: We studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion.

Methods: Nine hundred nine women undergoing second level screening because they had been positive at cervical cytology were enrolled. All the patients underwent colposcopy and cervical biopsy with viral genotyping. Read More

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http://dx.doi.org/10.1186/s12885-020-06946-7DOI Listing

Exploratory analysis of immune checkpoint receptor expression by circulating T cells and tumor specimens in patients receiving neo-adjuvant chemotherapy for operable breast cancer.

BMC Cancer 2020 May 19;20(1):445. Epub 2020 May 19.

The Ohio State University Comprehensive Cancer Center, The Ohio State University, 410 W 12th Avenue, Columbus, OH, 43210, USA.

Background: While combinations of immune checkpoint (ICP) inhibitors and neo-adjuvant chemotherapy (NAC) have begun testing in patients with breast cancer (BC), the effects of chemotherapy on ICP expression in circulating T cells and within the tumor microenvironment are still unclear. This information could help with the design of future clinical trials by permitting the selection of the most appropriate ICP inhibitors for incorporation into NAC.

Methods: Peripheral blood samples and/or tumor specimens before and after NAC were obtained from 24 women with operable BC. Read More

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http://dx.doi.org/10.1186/s12885-020-06949-4DOI Listing

The role of human papillomavirus genotyping for detecting high-grade intraepithelial neoplasia or cancer in HPV-positive women with normal cytology: a study from a hospital in northeastern China.

BMC Cancer 2020 May 19;20(1):443. Epub 2020 May 19.

Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, No.44 Xiaoheyan Road, Shenyang, 110042, Liaoning province, China.

Background: Human papillomavirus (HPV) testing is more sensitive than cytology for detecting cervical cancer and its precursors. This study aimed to analyze the prevalence of high-risk HPV genotypes and evaluate the role of HPV genotyping triage for detecting high-grade squamous intraepithelial lesions, adenocarcinoma in situ and cervical cancer (HSIL+) in HPV-positive women with normal cytology.

Methods: A retrospective study was performed in women who had undergone co-screening at the China Medical University-affiliated Shengjing Hospital between 2012 and 2014. Read More

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http://dx.doi.org/10.1186/s12885-020-06935-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236298PMC

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.

BMC Cancer 2020 May 19;20(1):447. Epub 2020 May 19.

Precision Neurotherapeutics Innovation Program, Mayo Clinic, 5777 East Mayo Blvd , SSB 02-700, Phoenix, AZ, 85054, USA.

Background: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.

Methods: Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females).

Results: Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1. Read More

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http://dx.doi.org/10.1186/s12885-020-06816-2DOI Listing

Preoperative SCC-Ag as a predictive marker for the use of adjuvant chemotherapy in cervical squamous cell carcinoma with intermediate-risk factors.

BMC Cancer 2020 May 19;20(1):441. Epub 2020 May 19.

Department of obstetrics and gynecology, the First Hospital of Lanzhou University, Key Laboratory of Gynecologic Oncology Gansu Province, No.1, Donggang West Road, Lanzhou, 730000, Gansu Province, China.

Background: For cervical cancer patients whose tumors display a combination of intermediate risk factors, postoperative radiation with or without adjuvant chemotherapy is suggested for them. However, who should be administered with adjuvant chemotherapy is unknown. The current study was designed to explore the clinical value of squamous cell carcinoma antigen (SCC-Ag) in guiding the use of adjuvant chemotherapy in cervical cancer patients. Read More

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http://dx.doi.org/10.1186/s12885-020-06928-9DOI Listing

Prevalence and correlates of job and insurance problems among young breast cancer survivors within 18 months of diagnosis.

BMC Cancer 2020 May 18;20(1):432. Epub 2020 May 18.

Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Background: The prevalence and correlates of job and insurance problems were examined among a cohort of young U.S. breast cancer survivors during the first 18-months following diagnosis. Read More

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http://dx.doi.org/10.1186/s12885-020-06846-wDOI Listing

DPD status and fluoropyrimidines-based treatment: high activity matters too.

BMC Cancer 2020 May 18;20(1):436. Epub 2020 May 18.

Centre Antoine-Lacassagne, Oncopharmacology Unit, Université Côte d'Azur, Nice, France.

Background: Dihydropyrimidine dehydrogenase (DPD) status is an indicator of a marked risk for toxicity following fluoropyrimidine (FP)-based chemotherapy. This notion is well-established for low DPD status but little is known about the clinical impact of high DPD activity. This study examined the possible link between high intrinsic lymphocytic DPD activity and overall survival, progression free survival and response to FP-based treatment in patients treated in our institution. Read More

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http://dx.doi.org/10.1186/s12885-020-06907-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236295PMC

Early prediction of pathologic response to neoadjuvant treatment of breast cancer: use of a cell-loss metric based on serum thymidine kinase 1 and tumour volume.

BMC Cancer 2020 May 18;20(1):440. Epub 2020 May 18.

Department of Oncology-Pathology, Karolinska Institute and University Hospital Solna, Stockholm, Sweden.

Background: After neoadjuvant chemotherapy of breast cancer pathologic complete response (pCR) indicates a favorable prognosis. Among non-selected patients, pCR is, however, achieved in only 10-30%. Early evaluation of tumour response to treatment would facilitate individualized therapy, with ineffective chemotherapy interrupted or changed. Read More

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http://dx.doi.org/10.1186/s12885-020-06925-yDOI Listing

Roles of DANCR/microRNA-518a-3p/MDMA ceRNA network in the growth and malignant behaviors of colon cancer cells.

BMC Cancer 2020 May 18;20(1):434. Epub 2020 May 18.

Department of Clinical Laboratory, HwaMei Hospital; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, No.41 Northwest Street, Ningbo, 315000, Zhejiang, People's Republic of China.

Background: The competing endogenous RNA (ceRNA) networks of long non-coding RNAs (lncRNAs) and microRNAs (miRs) have aroused wide concerns. The study aims to investigate the roles of lncRNA DANCR-associated ceRNA network in the growth and behaviors of colon cancer (CC) cells.

Methods: Differentially expressed lncRNAs between CC and paracancerous tissues were analyzed using microarrays and RT-qPCR. Read More

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http://dx.doi.org/10.1186/s12885-020-06856-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236548PMC

The combination of methotrexate and cytosine arabinoside in newly diagnosed adult Langerhans cell histiocytosis: a prospective phase II interventional clinical trial.

BMC Cancer 2020 May 18;20(1):433. Epub 2020 May 18.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Beijing, People's Republic of China.

Background: Langerhans Cell Histiocytosis (LCH) is a rare disease puzzling both children and adults, however outcome of adult patients is unfavorable. This prospective interventional trial aims to test the efficacy and safety of the combination of methotrexate and cytosine arabinoside in adult LCH patients.

Method: A total of 36 patients enrolled diagnosed with LCH and treated in our center from 1st Jan, 2014 to 30th Jun, 2016. Read More

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http://dx.doi.org/10.1186/s12885-020-06872-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236107PMC

Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC.

BMC Cancer 2020 May 18;20(1):430. Epub 2020 May 18.

Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Background: The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.

Methods: We evaluated the expression of estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemical staining and determined the predictive and prognostic role of HR expression on 189 patients with HR+/HER2- IBC and 677 patients with HR+/HER2- stage III non-IBC. Furthermore, we performed gene expression (GE) analyses on 137 patients with HR+/HER2- IBC and 252 patients with HR+/HER2- non-IBC to detect genes that are specifically overexpressed in IBC. Read More

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http://dx.doi.org/10.1186/s12885-020-06940-zDOI Listing

Physical activity and long-term fatigue among colorectal cancer survivors - a population-based prospective study.

BMC Cancer 2020 May 18;20(1):438. Epub 2020 May 18.

Unit of Cancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.

Background: Evidence suggests that physical activity (PA) is beneficial for reducing fatigue in colorectal cancer (CRC) survivors. However, little is known regarding long-term effects of PA on fatigue and whether pre-diagnosis PA is associated with less fatigue in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term fatigue in CRC survivors. Read More

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http://dx.doi.org/10.1186/s12885-020-06918-xDOI Listing

The association of depressive symptoms, personality traits, and sociodemographic factors with health-related quality of life and quality of life in patients with advanced-stage lung cancer: an observational multi-center cohort study.

BMC Cancer 2020 May 18;20(1):431. Epub 2020 May 18.

Department of Medical and Clinical Psychology, Centre of Research on Psychological and Somatic Disorders (CoRPS), Tilburg University, P.O. Box 90151, 5000, LE, Tilburg, The Netherlands.

Background: Identification of patient-related factors associated with Health-Related Quality of Life (HRQoL) and Quality of Life (QoL) at the start of treatment may identify patients who are prone to a decrease in HRQoL and/or QoL resulting from chemotherapy. Identification of these factors may offer opportunities to enhance patient care during treatment by adapting communication strategies and directing medical and psychological interventions. The aim was to examine the association of sociodemographic factors, personality traits, and depressive symptoms with HRQoL and QoL in patients with advanced-stage lung cancer at the start of chemotherapy. Read More

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http://dx.doi.org/10.1186/s12885-020-06823-3DOI Listing