Synaptic neuron-astrocyte communication is supported by an order of magnitude analysis of inositol tris-phosphate diffusion at the nanoscale in a model of peri-synaptic astrocyte projection.
BMC Biophys 2018 12;11. Epub 2018 Feb 12.
Unit of Dynamic Neurobiology, Neurochemistry Deprtment Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur #3877, Col. La Fama, C.P. 14269 Ciudad de México, Mexico.
Background: Astrocytes were conceived for decades only as supporting cells of the brain. However, the observation of Ca2+ waves in astrocyte synctitia, their neurotransmitter receptor expression and gliotransmitter secretion suggested a role in information handling, conception that has some controversies.(SN-AmcIP3) is supported by different reports. Read More