156,693 results match your criteria BMC Biology [Journal]
BMC Neurol 2018 Dec 15;18(1):207. Epub 2018 Dec 15.
Department of Medical Biology, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey.
Background: Alpha-dystroglycan (αDG) is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin globular domains and certain arenaviruses. An important enzyme, known as Like-acetylglucosaminyltransferase (LARGE), has been shown to transfer repeating units of -glucuronic acid-β1,3-xylose-α1,3- (matriglycan) to αDG that is required for functional receptor as an extracellular matrix protein scaffold. The reduction in the amount of LARGE-dependent matriglycan result in heterogeneous forms of dystroglycanopathy that is associated with hypoglycosylation of αDG and a consequent lack of ligand-binding activity. Read More
BMC Pediatr 2018 Dec 15;18(1):388. Epub 2018 Dec 15.
Children's Hospital of Michigan, Detroit, MI, USA.
Background: There have been few studies focused on the prevalence, bacterial etiology, antibiotic resistance, and genetic background of Staphylococcus aureus (S. aureus) in children with acute otitis media (AOM) in China.
Methods: A retrospective study was conducted in Liuzhou Maternity and Child Healthcare Hospital. Read More
BMC Neurol 2018 Dec 15;18(1):206. Epub 2018 Dec 15.
Department of Radiology, China-Japan Friendship Hospital, 2 Yinghuayuan Dongjie, Beijing, China.
Background: Two-dimensional high-resolution MRI (2D HRMRI) faces many technical challenges for fully assessing morphologic characteristics of inherent tortuous basilar arteries. Our aim was to investigate remodeling mechanisms and plaque distribution in symptomatic patients with basilar artery stenosis on three-dimensional (3D) HRMRI.
Methods: Forty-six consecutive patients with symptomatic basilar artery atherosclerotic stenosis on MRA (70-99%) were enrolled. Read More
BMC Res Notes 2018 Dec 14;11(1):898. Epub 2018 Dec 14.
Unité d'Immunologie, Institut Pasteur de Madagascar, Ambatofotsikely, P.O. Box 1274, Antananarivo, Madagascar.
Objectives: In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. Read More
BMC Infect Dis 2018 Dec 14;18(1):664. Epub 2018 Dec 14.
Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, 518112, China.
Background: Bacterial co-infection of patients suffering from influenza pneumonia is a key element that increases morbidity and mortality. The occurrence of Acinetobacter baumannii co-infection in patients with avian influenza A (H7N9) virus infection has been described as one of the most prevalent bacterial co-infections. However, the clinical and laboratory features of this entity of H7N9 and A. Read More
BMC Psychiatry 2018 Dec 14;18(1):389. Epub 2018 Dec 14.
Klinik für Psychiatrie und Psychotherapie, Zentrum für Psychosoziale, Medizin, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20, ,246, Hamburg, Germany.
Following publication of the original article. Read More
BMC Med Inform Decis Mak 2018 Dec 14;18(1):132. Epub 2018 Dec 14.
Department of Epidemiology and Biostatistics, Amsterdam UMC, location VUMC, F-wing Medical Faculty building, PO Box 7057 1007, MB, Amsterdam, The Netherlands.
Background: Decision-making about palliative care for metastatic colorectal cancer (mCRC) consists of many different treatment-related decisions, and there generally is no best treatment option. Decision support systems (DSS), e.g. Read More
BMC Public Health 2018 Dec 14;18(1):1374. Epub 2018 Dec 14.
Centre for Ergonomics and Human Factors, School of Psychology and Public Health, College of Science, Health and Engineering, Latrobe University, Melbourne, Australia.
Background: Many workplaces have implemented sit-stand workstations (SSW), which enable a worker to transition between sitting and standing as they perform their work activities. The factors which determine the initial adoption, sustainability or cessation of use for a SSW, remain largely unexamined. This study investigates the experiences of workers who had previously used or were currently using a SSW. Read More
Biomed Chromatogr 2018 Dec 13:e4467. Epub 2018 Dec 13.
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China.
To characterize the preclinical plasma pharmacokinetics of entrectinib, a reproducible and precise assay is necessary. In this study, we developed and validated a simple ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the measurement of entrectinib using carbamazepine as the internal standard (IS) in rat plasma. Sample preparation was a simple protein precipitation with acetonitrile, then entrectinib was eluted on an Acquity UPLC BEH C18 column (2. Read More
Biomed Chromatogr 2018 Dec 13:e4469. Epub 2018 Dec 13.
Drug Metabolism and Interactions Research Lab, Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Green tea extracts (GTE) has been reported to be a kinase inhibitor and modulator for various drug metabolizing enzymes. It may give synergetic antioncogenic effect, but with a possibility of pharmacokinetic interactions with various co-administered anticancer agents like palbociclib (PAL), a selective inhibitor of CDK-4/6 primarily metabolized by CYP3A4 enzyme. To explore the impact of GTE on PAL pharmacokinetics in Sprague Dawley rats, a rapid and sensitive UHPLC-QTOF-MS method was established. Read More
Biomed Chromatogr 2018 Dec 13:e4468. Epub 2018 Dec 13.
Department of Psychiatry, İzmir Katip Çelebi University, Ataturk Training and Research Hospital, İzmir, Turkey.
Olanzapine is an atypical antipsychotic drug from thienobenzodiazepine family which displays efficacy in patients with schizophrenia and related psychoses. A novel LC/MS method was developed and validated for determination of olanzapine in schizophrenia patients plasma. A liquid-liquid extraction procedure carried out by using 5 mL diethyl ether-diisopropyl ether mixture (1:1, v/v). Read More
Biomed Chromatogr 2018 Dec 13:e4471. Epub 2018 Dec 13.
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre-RS, Brazil.
Carbapenems show recognized instability in aqueous solutions, therefore some care must be taken from its handling and preparation to its use in the hospital environment. Here, the stability and degradation products of imipenem were investigated from conditions that simulate its clinical use. For this, a simple stability-indicating method by HPLC-DAD was validated with focus on quantitation of drug concentration remaining from infusion solutions (sodium chloride 0. Read More
Biomed Chromatogr 2018 Dec 12:e4461. Epub 2018 Dec 12.
Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Compound 27 [1, 12-bis(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)dodecane-1,12-dione ] is a novel small molecule agonist of EphA2 receptor Tyrosine Kinase. It showed much improved activity for the activation of EphA2 receptor compared to the parental compound Doxazosin. To support further pharmacological and toxicological studies of the compound, a method using liquid chromatography and electrospray ionization tandem mass spectrometry (LC- MS/MS) has been developed for the quantification of this compound. Read More
Biomed Chromatogr 2018 Dec 11:e4465. Epub 2018 Dec 11.
Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Carbenoxolone is a derivative of glycyrrhetinic acid found in the root of Glycyrrhiza glabra, colloquially known as licorice. It has been used as a treatment for peptic and oral ulcers. In recent years, carbenoxolone has been utilized in basic research for its ability to block gap junctional communication. Read More
BMC Res Notes 2018 Dec 14;11(1):895. Epub 2018 Dec 14.
Virus and Prion Research Unit, National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, IA, 50010, USA.
Objective: Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the misfolding of the cellular prion protein (PrP) into a pathogenic form (PrP) that accumulates in the brain and lymphatic tissue. Amplification based assays such as real-time quaking induced conversion allow us to assess the conversion of PrP to PrP. Read More
BMC Res Notes 2018 Dec 14;11(1):893. Epub 2018 Dec 14.
Health and Human (2HD) Research Network, Douala, Cameroon.
Objectives: Burnout syndrome is common amongst medical personnel. The objective of this study was to identify determinants of burnout syndrome among nurses in the north west and south west regions of Cameroon.
Results: A cross-sectional analysis during the months of January-June 2018 was carried out recruiting nurses consecutively after consent from state-owned and private hospitals in the English-speaking regions of Cameroon. Read More
BMC Res Notes 2018 Dec 14;11(1):897. Epub 2018 Dec 14.
School of Mathematics and Statistics, University College Dublin, Belfield, Dublin 4, Dublin, Ireland.
Objectives: Neural networks are a powerful statistical tool that use nonlinear regression type models to obtain predictions. Their use in the Lifeways cross-generation study that examined body mass index (BMI) of children, among other measures, is explored here. Our aim is to predict the BMI of children from that of their parents and maternal and paternal grandparents. Read More
BMC Syst Biol 2018 Dec 14;12(Suppl 7):91. Epub 2018 Dec 14.
Department of Genetics and Biochemistry, Clemson University, Clemson, SC, 29646, USA.
Background: Autism Spectrum Disorder (ASD) is the umbrella term for a group of neurodevelopmental disorders convergent on behavioral phenotypes. While many genes have been implicated in the disorder, the predominant focus of previous research has been on protein coding genes. This leaves a vast number of long non-coding RNAs (lncRNAs) not characterized for their role in the disorder although lncRNAs have been shown to play important roles in development and are highly represented in the brain. Read More
BMC Psychol 2018 Dec 14;6(1):58. Epub 2018 Dec 14.
Department of Psychology, University of Bielefeld, Bielefeld, Germany.
Background: Disorders-of-consciousness (DOC) are rare conditions leading to very severe physical and mental disabilities. Providing care for DOC patients has been described as a stressful experience, eroding the physical and psychological health of the caregiver. Different forms of care may have different impacts on the caregivers and institutionalized care has been suggested to have an unburdening effect, but this possibility has never been empirically studied. Read More
BMC Res Notes 2018 Dec 14;11(1):891. Epub 2018 Dec 14.
Department of Reproductive Health, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Objective: The objective of this study was to determine the prevalence and determinants of unintended pregnancy among reproductive age women in Bahir Dar town, Northwest Ethiopia.
Result: The prevalence of unintended pregnancy was 15.8% (95% CI 13. Read More
BMC Ophthalmol 2018 Dec 14;18(1):322. Epub 2018 Dec 14.
Department of Ophthalmology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
Background: This study aimed to investigate patient adherence to face-down positioning (FDP) and non-supine positioning (NSP) following vitrectomy with gas tamponade for treating macular holes (MHs).
Methods: Nursing records of 92 patients who underwent vitrectomy with gas tamponade for small-diameter (diameter < 400 μm) MHs during April 2016-June 2017 were examined. Forty-seven and 45 patients were instructed to maintain FDP and NSP (FDP and NSP groups), respectively. Read More
BMC Res Notes 2018 Dec 14;11(1):892. Epub 2018 Dec 14.
Department of Reproductive Health, Institute of Public Health, College of Medicine and Health Science, University of Gondar, 196, Gondar, Ethiopia.
Objective: The objective of the study was to assess prevalence low dietary diversity and associated factors among lactating mother in Angecha district, Southern Ethiopia.
Results: The magnitude of low dietary diversity was 52.2%, 95% confidence interval (47. Read More
BMC Res Notes 2018 Dec 14;11(1):896. Epub 2018 Dec 14.
University Obstetrics Unit, De Soysa Hospital for Women, Colombo, Sri Lanka.
Objectives: Data was gathered to study the impact of a context-specific modified WHO Safe Childbirth Checklist (mSCC) at two tertiary care settings in Sri Lanka, as a part of an implementation program.
Data Description: We provide data sets of a prospective observational study which was conducted in the University Obstetrics Unit at De Soysa Hospital for Women (DSHW), Colombo and two Obstetric Units at Teaching Hospital, Mahamodara, Galle (THMG), Sri Lanka. These consist of demographic and checklist implementation details and data on the level of acceptance. Read More
Addict Sci Clin Pract 2018 Dec 14;13(1):26. Epub 2018 Dec 14.
Department of Pediatrics, Boston University School of Medicine, Boston Medical Center, Boston, MA, 02118, USA.
Background: Little is known about opioid overdose or naloxone access among pregnant women.
Objectives: The objectives of this study were to determine the prevalence of non-fatal overdose, risk factors for overdose, and naloxone access among third trimester women in treatment for opioid use disorder.
Methods: We collected baseline data from a case management parental-support intervention study. Read More
BMC Res Notes 2018 Dec 14;11(1):894. Epub 2018 Dec 14.
Sir William Dunn School of Pathology, University of Oxford, South Park Roads, Oxford, OX1 3RE, UK.
Objectives: Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is a highly regulated process. Most human genes have multiple poly(A) sites, which define different possible mRNA ends, suggesting the existence of mechanisms that regulate which poly(A) site is used. Poly(A) site selection may be mediated by cleavage factor I (CFIm), which is part of the cleavage and polyadenylation (CPA) complex. Read More
BMC Pregnancy Childbirth 2018 Dec 14;18(1):496. Epub 2018 Dec 14.
AP-HP Health Economics Clinical Research Platform (URCEco), Hotel Dieu, Place de Parvis, 75004, Paris, France.
Background: The determination of foetal Rhesus D (RHD) status allows appropriate use of IgRh prophylaxis by restricting its use to cases of RHD feto-maternal incompatibilities. There is a degree of uncertainty about the cost-effectiveness of foetal RHD determination, yet screening programs are being introduced into clinical practice in many countries. This paper evaluates the impact of non-invasive foetal Rhesus D (RHD) status determination on the costs of managing RHD-negative pregnant women and on the appropriate use of anti-D prophylaxis in a large sample of RHD-negative pregnant women using individual prospectively collected clinical and economic data. Read More
BMC Syst Biol 2018 Dec 14;12(Suppl 7):117. Epub 2018 Dec 14.
MidSouth Bioinformatics Center and Joint Bioinformatics Ph.D. Program, University of Arkansas at Little Rock and University of Arkansas for Medical Sciences, 2801 S. University Avenue, Little Rock, AR, 72204, USA.
Background: Adenocarcinoma in situ (AIS) is a pre-invasive lesion in the lung and a subtype of lung adenocarcinoma. The patients with AIS can be cured by resecting the lesion completely. In contrast, the patients with invasive lung adenocarcinoma have very poor 5-year survival rate. Read More
BMC Syst Biol 2018 Dec 14;12(Suppl 7):116. Epub 2018 Dec 14.
Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun, 130012, China.
Background: Nowadays, because of the huge economic burden on society causing by obesity and diabetes, they turn into the most serious public health challenges in the world. To reveal the close and complex relationships between diabetes, obesity and other diseases, search the effective treatment for them, a novel model named as representative latent Dirichlet allocation (RLDA) topic model is presented.
Results: RLDA was applied to a corpus of more than 337,000 literatures of diabetes and obesity which were published from 2007 to 2016. Read More
BMC Syst Biol 2018 Dec 14;12(Suppl 7):92. Epub 2018 Dec 14.
Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, MS, 39180, USA.
Background: Ecotoxicological studies on the insensitive munitions formulation IMX-101 and its components 2,4-dinitroanisole (DNAN), nitroguanidine (NQ) and nitrotriazolone (NTO) in various organisms showed that DNAN was the main contributor to the overall toxicity of IMX-101 and suggested that the three compounds acted independently. These results motivated this toxicogenomics study to discern toxicological mechanisms for these compounds at the molecular level.
Methods: Here we used the soil nematode Caenorhabditis elegans, a well-characterized genomics model, as the test organism and a species-specific, transcriptome-wide 44 K-oligo probe microarray for gene expression analysis. Read More
BMC Neurol 2018 Dec 14;18(1):205. Epub 2018 Dec 14.
Department of Neurology, University of Kansas Medical Center, Kansas City, USA.
Background: To assess the feasibility of using automated capture of Electronic Medical Record (EMR) data to build predictive models for amyotrophic lateral sclerosis (ALS) outcomes.
Methods: We used an Informatics for Integrating Biology and the Bedside search discovery tool to identify and extract data from 354 ALS patients from the University of Kansas Medical Center EMR. The completeness and integrity of the data extraction were verified by manual chart review. Read More
BMC Oral Health 2018 Dec 14;18(1):218. Epub 2018 Dec 14.
Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, P.O. Box 7804, N-5020, Bergen, Norway.
Background: Family physicians are in frequent contact with patients, and their contribution to oral health promotion programs could be utilized more effectively. We implemented an oral health care (OHC) educational seminar for physicians and evaluated its impact on their knowledge retention in OHC.
Methods: We conducted an educational trial for primary care physicians (n = 106) working in Public Health Centers in Tehran city. Read More
BMC Syst Biol 2018 Dec 14;12(Suppl 7):114. Epub 2018 Dec 14.
Joint Bioinformatics Program, University of Arkansas Little Rock George Washington Donaghey College of Engineering & IT and University of Arkansas for Medical Sciences, Little Rock, AR, 72204, USA.
Background: Single-cell RNA sequencing (scRNA-seq) technology provides an effective way to study cell heterogeneity. However, due to the low capture efficiency and stochastic gene expression, scRNA-seq data often contains a high percentage of missing values. It has been showed that the missing rate can reach approximately 30% even after noise reduction. Read More
BMC Health Serv Res 2018 Dec 14;18(1):968. Epub 2018 Dec 14.
Health Management Unit, Open University of Cyprus, Nicosia, Cyprus.
Background: Family-centered care has been receiving increased attention during the last decades and health professionals recognize family satisfaction with care as an important health indicator. The Empowerment of Parents in The Intensive Care-Neonatology (EMPATHIC-N) is a newly developed, yet empirically reliable and valid measure for the assessment of parental satisfaction with the care provided by Neonatal Intensive Care Units (NICU). The present study aims to present the Greek version of the EMPATHIC-N and to confirm its factorial structure. Read More
BMC Syst Biol 2018 Dec 14;12(Suppl 7):115. Epub 2018 Dec 14.
School of Computing, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Background: Reconstruction of gene regulatory networks (GRNs), also known as reverse engineering of GRNs, aims to infer the potential regulation relationships between genes. With the development of biotechnology, such as gene chip microarray and RNA-sequencing, the high-throughput data generated provide us with more opportunities to infer the gene-gene interaction relationships using gene expression data and hence understand the underlying mechanism of biological processes. Gene regulatory networks are known to exhibit a multiplicity of interaction mechanisms which include functional and non-functional, and linear and non-linear relationships. Read More
BMC Vet Res 2018 Dec 14;14(1):400. Epub 2018 Dec 14.
College of Veterinary Medicine, Hebei Agricultural University, Baoding, 071001, Hebei, China.
Background: Since July in 2015, an emerging infectious disease, Fowl adenovirus (FAdV) species C infection with Hepatitis-Hydropericardium syndrome was prevalent in chicken flocks in China. In our study, one FAdV strain was isolated from commercial broiler chickens and was designated as SDSX1.The phylogenetic information, genetic mutations and pathogenicity of SDSX1 were evaluated. Read More
BMC Health Serv Res 2018 Dec 14;18(1):965. Epub 2018 Dec 14.
Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177, Stockholm, Sweden.
Background: Clinical practice guidelines risk having little impact on healthcare if not effectively implemented. Theory informed, targeted implementation may maximise their impact. Our study explored barriers to and facilitators of guideline implementation and use by South African primary care nurses and allied healthcare workers in four provinces in South Africa. Read More
BMC Med Educ 2018 Dec 14;18(1):307. Epub 2018 Dec 14.
Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
Background: Including content on Indigenous health in medical school curricula has become a widely-acknowledged prerequisite to reducing the health disparities experienced by Indigenous peoples in Canada. However, little is known about what levels of awareness and interest medical students have about Indigenous peoples when they enter medical school. Additionally, it is unclear whether current Indigenous health curricula ultimately improve students' beliefs and behaviours. Read More
BMC Public Health 2018 Dec 14;18(1):1373. Epub 2018 Dec 14.
Department of Health, Behaviour and Society, Jimma University, Jimma, Ethiopia.
Background: Ethiopia is currently facing new challenges related to food insecurity among the urban poor. Pensioners are segments of the population with reduced income and working capacity because of advancement of age and other related problems. There is no empirical evidence on Jimma Town pensioner's household food insecurity and coping strategies. Read More
BMC Health Serv Res 2018 Dec 14;18(1):967. Epub 2018 Dec 14.
Institute for Choice, University of South Australia Business School, Adelaide, SA, Australia.
Background: This paper reports the methods and findings from a systematic review of economic evaluations conducted in the community aged care sector between 2000 and 2016.
Methods: Online databases searched were PubMed, Medline, Scopus, and web of science, CINAHL and informit. Studies were included if they 1) were full economic evaluations that compared both the costs and outcomes of two or more interventions 2) in study population of people aged 65 years and over 3) dependent older people living in the community 4) alternatives being compared were care models or service delivery interventions in the community aged care sector (a group of programs that have been established as a support system to allow older people to remain living in their own homes for as long as possible, as an alternative to institutional or residential care) and 5) published in the English language between 2000 and November 2016. Read More
BMC Ecol 2018 Dec 14;18(1):57. Epub 2018 Dec 14.
Limnological Institute, University of Konstanz, Mainaustrasse 252, 78464, Constance, Germany.
Background: The relative importance of nutrients derived from different sources for tissue synthesis is crucial for predicting a species responds to changes in food availability. The ecological and physiological strategies that govern the incorporation and routing of nutrients for reproduction are often well understood. However, the role and adaptive value of both species and individual variation during early life-stage remain elusive. Read More
BMC Med Genomics 2018 Dec 14;11(1):111. Epub 2018 Dec 14.
Centre for Pharmacology and Toxicology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Background: Non-alcoholic fatty liver disease (NAFLD) is a major health burden in need for new medication. To identify potential drug targets a genomic study was performed in lipid-laden primary human hepatocyte (PHH) and human hepatoma cell cultures.
Methods: PHH, HuH7 and HepG2 hepatoma cell cultures were treated with lipids and/or TNFα. Read More
BMC Complement Altern Med 2018 Dec 14;18(1):335. Epub 2018 Dec 14.
Department of Rural Health, University of South Australia, North Terrace, Adelaide, SA, 5000, Australia.
Background: As Complementary and Alternative medicine (CAM) grows in popularity, there is overt recognition for research evidence to inform clinical practice. While various strategies have been trialed to overcome the barriers to such progress, it is important to first understand the extent to which these barriers impact the conduct and application of CAM research. This study aimed to garner consensus and agreement among CAM researchers and practitioners in refining and validating a preliminary survey instrument for measuring these barriers. Read More
BMC Syst Biol 2018 Dec 14;12(Suppl 7):118. Epub 2018 Dec 14.
National Medical Centre of Colorectal Disease, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001, China.
Background: Bladder cancer (BC) is the most common cancer of the urinary bladder and upper tract, in which the clinical management is limited. AURKA (aurora kinase A) has been identified as an oncogene in cancer development; however, its potential role and underlying mechanisms in the progression of BC remain unknown.
Results: In this study, we evaluated Aurora kinase A (AURKA) expression in patient samples by performing gene expression profiling, and found that AURKA expression levels were significantly higher in BC tissues than in normal tissues. Read More
BMC Med Educ 2018 Dec 14;18(1):308. Epub 2018 Dec 14.
Department of Oral and Maxillofacial Surgery, Erlangen University Hospital, Friedrich-Alexander University Erlangen-Nuremberg, Glückstrasse 11, 91054, Erlangen, Germany.
Background: Local anesthesia is an important skill and a prerequisite for most dental treatments. However, the step from theory to application on the patient is huge for the novice. Hence, a mannequin training model course was developed and implemented into the existing local anesthesia curriculum in undergraduate dental students. Read More
BMC Health Serv Res 2018 Dec 14;18(1):966. Epub 2018 Dec 14.
Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Al-Hodeida University, Al-Hodeida, Yemen.
Background: Medication discrepancies are seen frequently in hospital setting upon admission or discharge. Medication Reconciliation service is a practice designed to ensure that patients' medications are ordered in a correct manner upon hospital admission, thus reducing the risk of having medication discrepancies. This study aimed to determine the prevalence of medication discrepancies and their clinical seriousness in pediatric patients at the time of hospital admission. Read More
BMC Vet Res 2018 Dec 14;14(1):397. Epub 2018 Dec 14.
Institute of Veterinary Science, University of Liverpool, Neston, UK.
Background: The most common approach for controlled weight loss in cats is dietary caloric restriction, using a purpose-formulated diet. Most previous studies have only assessed short-term outcomes, and no previous study has examined overall success (i.e. Read More
BMC Biotechnol 2018 Dec 14;18(1):80. Epub 2018 Dec 14.
Liaoning Province Key Laboratory of Agricultural Technology, College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, 110866, China.
Background: More than a dozen of fungal immunomodulatory proteins (FIPs) have been identified to date, most of which are from Ganoderma species. However, little is known about the similarities and differences between different Ganoderma FIPs' bioactivities. In the current study, two FIP genes termed FIP-gap1 and FIP-gap2 from G. Read More
BMC Health Serv Res 2018 Dec 14;18(1):969. Epub 2018 Dec 14.
Research Department of Practice and Policy, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Background: A previous census of electronic prescribing (EP) systems in England showed that more than half of hospitals with EP reported more than one EP system within the same hospital. Our objectives were to describe the rationale for having multiple EP systems within a single hospital, and to explore perceptions of stakeholders about the advantages and disadvantages of multiple systems including any impact on patient safety.
Methods: Hospitals were selected from previous census respondents. Read More
BMC Complement Altern Med 2018 Dec 14;18(1):334. Epub 2018 Dec 14.
Africa Mental Health Foundation and Department of Psychiatry, University of Nairobi, Mawensi Road, Off Elgon road, Mawensi Garden, P.O. BOX 48423-00100, Nairobi, Kenya.
Background: Involvement of traditional health practitioners (THPs) in the form of collaboration with the formal health care system is suggested to improve the pathways to mental health care in Kenya, yet understanding of the current traditional practice and THPs' perspectives is lacking. The aim of this study was to explore the views of THPs with respect to their mental health practice.
Methods: This study qualitatively explored the views of THPs, using four focus group discussions (FDGs) each consisting of 8-10 traditional and faith healers, resulting in a total of 36 participants. Read More
BMC Pregnancy Childbirth 2018 Dec 14;18(1):495. Epub 2018 Dec 14.
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Firouzeh St., South Vali- Asr Ave., Vali- Asr Sq., Tehran, 15937-16615, Iran.
Background: Growing evidence indicates that the risk of obstetric and perinatal outcomes is higher in women with assisted reproductive technology (ART). However, there is little known about pregnancy related complications and co-morbidity in gestational diabetes mellitus (GDM) following singleton pregnancies achieved by ART in comparison with spontaneous conception (SC).
Methods: Two hundred sixty singleton pregnant women conceived by ART and 314 pregnant women conceived by spontaneous conception (SC) were participated in this prospective cohort study. Read More