BMC Bioinformatics 2018 Jun 15;19(1):227. Epub 2018 Jun 15.
Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Background: What is a healthy microbiome? The pursuit of this and many related questions, especially in light of the recently recognized microbial component in a wide range of diseases has sparked a surge in metagenomic studies. They are often not simply attributable to a single pathogen but rather are the result of complex ecological processes. Relatedly, the increasing DNA sequencing depth and number of samples in metagenomic case-control studies enabled the applicability of powerful statistical methods, e. Read More