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    877 results match your criteria BMC Anesthesiology[Journal]

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    Paravertebral dexmedetomidine as an adjuvant to ropivacaine protects against independent lung injury during one-lung ventilation: a preliminary randomized clinical trial.
    BMC Anesthesiol 2018 Jun 15;18(1):67. Epub 2018 Jun 15.
    Department of Anesthesiology, Henan Provincial People's Hospital, No. 7, Weiwu Road, Zhengzhou City, Henan Province, China.
    Background: To investigate the effect of paravertebral dexmedetomidine as an adjuvant to ropivacaine on independent lung injury during one-lung ventilation.

    Methods: In total, 120 patients who underwent elective radical resection of pulmonary carcinoma were randomly assigned to one of six groups (n = 20): normal saline (C group), ropivacaine (R group), intravenous dexmedetomidine (Div group), 0.5 μg/kg paravertebral dexmedetomidine as an adjuvant to ropivacaine (RD0. Read More

    Bispectral index to guide induction of anesthesia: a randomized controlled study.
    BMC Anesthesiol 2018 Jun 15;18(1):66. Epub 2018 Jun 15.
    Department of Anesthesia and Intensive Care, University Hospital Giessen-Marburg, Marburg Campus, Baldingerstraße, 35033, Marburg, Germany.
    Background: It is unknown to what extent hypotension frequently observed following administration of propofol for induction of general anesthesia is caused by overdosing propofol. Unlike clinical signs, electroencephalon-based cerebral monitoring allows to detect and quantify an overdose of hypnotics. Therefore, we tested whether the use of an electroencephalon-based cerebral monitoring will cause less hypotension following induction with propofol. Read More

    Decannulation of tracheotomized patients after long-term mechanical ventilation - results of a prospective multicentric study in German neurological early rehabilitation hospitals.
    BMC Anesthesiol 2018 Jun 13;18(1):65. Epub 2018 Jun 13.
    University of Potsdam, Center of Rehabilitation Research, Am Neuen Palais 10, 14469, Potsdam, Germany.
    Background: In the course of neurological early rehabilitation, decannulation is attempted in tracheotomized patients after weaning due to its considerable prognostic significance. We aimed to identify predictors of a successful tracheostomy decannulation.

    Methods: From 09/2014 to 03/2016, 831 tracheotomized and weaned patients (65. Read More

    Does implementation of an enhanced recovery after surgery program for hip replacement improve quality of recovery in an Australian private hospital: a quality improvement study.
    BMC Anesthesiol 2018 Jun 13;18(1):64. Epub 2018 Jun 13.
    Epworth HealthCare, 89 Bridge Rd, Richmond, Vic, 3121, Australia.
    Background: Enhanced recovery after surgery programs may improve recovery and reduce duration of hospital stay after joint replacement surgery. However, uptake is incomplete, and the relative importance of program components is unknown. This before-and-after quality improvement study was designed to determine whether adding 'non-surgical' components, to pre-existing 'surgical' components, in an Australian private healthcare setting, would improve patient recovery after total hip replacement. Read More

    Evaluation of hemodynamic goal-directed therapy to reduce the incidence of bone cement implantation syndrome in patients undergoing cemented hip arthroplasty - a randomized parallel-arm trial.
    BMC Anesthesiol 2018 Jun 6;18(1):63. Epub 2018 Jun 6.
    Department of Anaesthesiology and Critical Care, Medical Center - University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
    Background: The bone cement implantation syndrome (BCIS) is a frequent and potentially disastrous intraoperative complication in patients undergoing cemented hip arthroplasty. Several risk factors have been identified, however randomized controlled trials to reduce the incidence of BCIS are still pending. We hypothesized that goal-directed hemodynamic therapy guided by esophageal Doppler monitoring (EDM) may reduce the incidence of BCIS in a randomized, controlled parallel-arm trial. Read More

    Comparative addition of dexmedetomidine and fentanyl to intrathecal bupivacaine in orthopedic procedure in lower limbs.
    BMC Anesthesiol 2018 Jun 6;18(1):62. Epub 2018 Jun 6.
    Rasoul-e-Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran.
    Background: Spinal block is a common procedure for lower limbs surgery. Fentanyl, a synthetic opioid and dexmedetomidine, a selective α2 agonist have been used as adjuvants in spinal anesthesia to prolong intraoperative and postoperative analgesia. The aim of current study is to compare the efficacy of dexmedetomidine and fentanyl added to intrathecal bupivacaine in orthopedic procedures in lower limbs. Read More

    Evaluation of small intestinal damage in a rat model of 6 Minutes cardiac arrest.
    BMC Anesthesiol 2018 Jun 5;18(1):61. Epub 2018 Jun 5.
    Experimental Medicine, University Hospital of Cologne, Robert-Koch-Str.10, Cologne, Germany.
    Background: Contribution of the small intestine to systemic inflammation after cardiac arrest (CA) is poorly understood. The objective was to evaluate whether an in vivo rat model of 6 min CA is suitable to initiate intestinal ischaemia-reperfusion-injury and to evaluate histomorphological changes and inflammatory processes in the small intestinal mucosa resp. in sera. Read More

    Entrapment of a laryngotracheal topical anesthesia kit during tracheobronchial foreign body removal: a case report.
    BMC Anesthesiol 2018 Jun 1;18(1):60. Epub 2018 Jun 1.
    Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
    Background: In order to reduce the irritation of the airway during tracheobronchial foreign body (TFB) removal, tracheal surface anesthesia is usually performed using a laryngotracheal topical anesthesia (LTA) kit (LTA20, Highgreen Medical Technology Company, China), but difficulty in withdrawing the LTA kit is rarely reported. We present a case of a difficulty to withdraw the LTA kit due to its entrapment by the movement of a TFB.

    Case Presentation: A 1-year-old girl was undergoing TFB removal. Read More

    Association between the use of a stylet in endotracheal intubation and postoperative arytenoid dislocation: a case-control study.
    BMC Anesthesiol 2018 May 31;18(1):59. Epub 2018 May 31.
    Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Backgrounds: Arytenoid dislocation (AD) is a rare but severe complication after general anesthesia with endotracheal intubation. We conducted a case-control study at Peking Union Medical College Hospital to identify risk factors associated with AD, including the use of an intubation stylet.

    Methods: Patients who experienced AD were matched 1:3 with controls based on gender, age and type of surgery. Read More

    Correction to: Advances in anesthesia technology are improving patient care, but many challenges remain.
    BMC Anesthesiol 2018 May 30;18(1):58. Epub 2018 May 30.
    Departments of Anesthesia and Health Research Methods, Evidence, and Impact, Michael DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West Hamilton, Hamilton, ON, L8S 4L8, Canada.
    Unfortunately, after publication of this article [1], it was noticed that the name of Ashraf A. Dahaba is incorrectly displayed as Ashraf Dahaba. The full, corrected author list can be seen here. Read More

    Anaesthesia for chest wall reconstruction in a patient with Poland syndrome: CARE-compliant case report and literature review.
    BMC Anesthesiol 2018 May 24;18(1):57. Epub 2018 May 24.
    Department of Anesthesiology and Pain medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, 430030, People's Republic of China.
    Background: Poland syndrome is a rare congenital disease, characterized by agenesis/hypoplasia of the pectoralis major muscle, usually associated with variable thoracic anomalies that needed chest wall reconstruction under general anesthesia. Anaesthetic management in Poland syndrome has scarcely been described.

    Case Presentation: Here, we present our anaesthetic management of Nuss procedure for chest wall correction in a 5 years old patient with Poland syndrome. Read More

    In vitro investigation of the effects of exogenous sugammadex on coagulation in orthopedic surgical patients.
    BMC Anesthesiol 2018 May 24;18(1):56. Epub 2018 May 24.
    Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
    Background: Previous studies have shown that sugammadex resulted in the prolongation of prothrombin time and activated partial thromboplastin time. In this study, we aimed to investigate the in vitro effects of exogenous sugammadex on the coagulation variables of whole blood in healthy patients who underwent orthopedic surgery.

    Methods: The effects of sugammadex on coagulations were assessed using thromboelastography (TEG) in kaolin-activated citrated blood samples taken from 14 healthy patients who underwent orthopedic surgery. Read More

    Prediction of fluid responsiveness in mechanically ventilated cardiac surgical patients: the performance of seven different functional hemodynamic parameters.
    BMC Anesthesiol 2018 May 22;18(1):55. Epub 2018 May 22.
    Institute of Anesthesiology and Intensive Care Medicine, Triemli City Hospital Zurich, Birmensdorferstr. 497, 8063, Zurich, Switzerland.
    Background: Functional hemodynamic parameters such as stroke volume and pulse pressure variation (SVV and PPV) have been shown to be reliable predictors of fluid responsiveness in mechanically ventilated patients. Today, different minimally- and non-invasive hemodynamic monitoring systems measure functional hemodynamic parameters. Although some of these parameters are described by the same name, they differ in their measurement technique and thus may provide different results. Read More

    Association between troponin-I levels and outcome in critically ill patients admitted to non-cardiac intensive care unit with high prevalence of cardiovascular risk factors.
    BMC Anesthesiol 2018 May 22;18(1):54. Epub 2018 May 22.
    Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
    Background: The association of troponin-I levels and outcome in medical-surgical ICU patients has been studied before in populations with low to moderate prevalence of cardiovascular risk factors. The objective in this article is to examine the association of troponin-I levels with hospital mortality in patients with high prevalence of cardiovascular risk factors who were admitted with medical-surgical indications to a non-cardiac intensive care unit.

    Methods: This was a retrospective study of adult patients admitted to a tertiary medical-surgical ICU between July 2001 and November 2011. Read More

    Role of ultrasound guided transversus abdominis plane block as a component of multimodal analgesic regimen for lower segment caesarean section: a randomized double blind clinical study.
    BMC Anesthesiol 2018 May 14;18(1):53. Epub 2018 May 14.
    Department of Anaesthesia and Pain Relief Service, Tata Motors Hospital, Telco Colony, Jamshedpur, Jharkhand, 831004, India.
    Background: While opioids are the mainstay for post-operative analgesia after lower segment caesarean section, they are associated with various untoward effects. Ultrasound guided transversus abdominis plane (TAP) block has been postulated to provide effective analgesia for caesarean section. We evaluated the analgesic efficacy of this block for post caesarean analgesia in a randomised controlled trial. Read More

    Ketamine exacerbates cortical neuroapoptosis under hyperoxic conditions by upregulating expression of the N-methyl-D-aspartate receptor subunit NR1 in the developing rat brain.
    BMC Anesthesiol 2018 May 10;18(1):52. Epub 2018 May 10.
    Department of Rehabilitation, China Rehabilitation Research Center, Boai Hospital, School of Rehabilitation Medicine, Capital Medical University, 10 North Road, Fengtai District, Beijing, 100077, People's Republic of China.
    Background: Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory upregulation of the N-methyl-D-aspartate (NMDA) receptor NR1 subunit. This study investigated the impact of ketamine administration under hyperoxic conditions on cortical neuroapoptosis and NR1 subunit expression in the infant rat brain. Read More

    Investigating determinants for patient satisfaction in women receiving epidural analgesia for labour pain: a retrospective cohort study.
    BMC Anesthesiol 2018 May 9;18(1):50. Epub 2018 May 9.
    Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
    Background: Epidural analgesia is a popular choice for labour pain relief. Patient satisfaction is an important patient-centric outcome because it can significantly influence both mother and child. However, there is limited evidence in the correlations between clinical determinants and patient satisfaction. Read More

    Predictors of major complications after elective abdominal surgery in cancer patients.
    BMC Anesthesiol 2018 May 9;18(1):49. Epub 2018 May 9.
    Anesthesia Department, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    Background: Patients undergoing abdominal surgery for solid tumours frequently develop major postoperative complications, which negatively affect quality of life, costs of care and survival. Few studies have identified the determinants of perioperative complications in this group.

    Methods: We performed a prospective observational study including all patients (age > 18) undergoing abdominal surgery for cancer at a single institution between June 2011 and August 2013. Read More

    Procaine and saline have similar effects on articular cartilage and synovium in rat knee.
    BMC Anesthesiol 2018 May 9;18(1):51. Epub 2018 May 9.
    Department of Anesthesiology and Reanimation, Hacettepe University, Faculty of Medicine, Sıhhiye, Ankara, Turkey.
    Background: Intra-articular local anaesthetics are widely used for providing postoperative analgesia and decreasing the need for opioids. Procaine has proven positive effects in carpal tunnel syndrome and chondromalacia patella. However, the effect of procaine on articular cartilage has not yet been studied. Read More

    Deletion of soluble epoxide hydrolase attenuates mice Hyperoxic acute lung injury.
    BMC Anesthesiol 2018 Apr 27;18(1):48. Epub 2018 Apr 27.
    The Second Clinical Medical College of Lanzhou University & Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou, Gansu, 730030, China.
    Background: Recent studies reported that soluble epoxide hydrolase (sEH) plays an important role in lung diseases. However, the role of sEH in hyperoxia-induced ALI is unclear.

    Methods: ALI was induced by exposure to 100% oxygen in an airtight cage for 72 h in wild-type (WT) and sEH gene deletion (EPHX2) mice. Read More

    Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice.
    BMC Anesthesiol 2018 Apr 25;18(1):47. Epub 2018 Apr 25.
    Wicking Dementia Research and Education Centre , University of Tasmania, Hobart, Australia.
    Background: There is increasing interest in whether anesthetic agents affect the risk or progression of Alzheimer's disease (AD). To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a transgenic model of AD to investigate the effect of propofol on AD pathology.

    Methods: Six month-old amyloid precursor protein/presenilin 1 (APP/PS1) transgenic AD mice and control mice were exposed to 3 doses of propofol (200 mg/kg) or vehicle, delivered at monthly intervals. Read More

    Effects of bacterial translocation on hemodynamic and coagulation parameters during living-donor liver transplant.
    BMC Anesthesiol 2018 Apr 25;18(1):46. Epub 2018 Apr 25.
    Department of Anesthesia, Surgical Intensive Care and Pain Management, Faculty of Medicine, Cairo University, 1 Alsaray st, Almanial, Cairo, Egypt.
    Background: Bacterial translocation (BT) has been proposed as a trigger for stimulation of the immune system with consequent hemodynamic alteration in patients with liver cirrhosis. However, no information is available regarding its hemodynamic and coagulation consequences during liver transplantation.

    Methods: We screened 30 consecutive adult patients undergoing living-donor liver transplant for the presence of BT. Read More

    Dexmedetomidine infusion as an analgesic adjuvant during laparoscopic сholecystectomy: a randomized controlled study.
    BMC Anesthesiol 2018 Apr 20;18(1):44. Epub 2018 Apr 20.
    Department of Surgery, Anesthesiology and Intensive Care, Postgraduate Institute of Bogomolets National Medical University, 36 Peremohy avenue, Kiev, 03055, Ukraine.
    Background: Dexmedetomidine (DEX) has sedative, sympatholytic and analgesic effects and might be beneficial if used as an adjuvant to: improve analgesia; modulate haemodynamic responses to intubation and pneumoperitoneum and; reduce the number of opioid-associated adverse events. The aim of this study was to evaluate the efficacy and safety of DEX infusion during elective laparoscopic cholecystectomy (LC).

    Methods: A randomized, single-centre, parallel-group, placebo-controlled study was carried out between May 2016 and June 2017. Read More

    Protocol based evaluation for feasibility of extubation compared to clinical scoring systems after major oral cancer surgery safely reduces the need for tracheostomy: a retrospective cohort study.
    BMC Anesthesiol 2018 Apr 20;18(1):43. Epub 2018 Apr 20.
    Department of Anaesthesiology and Critical Care Medicine, Medical Center, University of Freiburg, Faculty of Medicine, Hugstetter Strasse 55, 79106, Freiburg, Germany.
    Background: Despite risks, complications and negative impact to quality of life, tracheostomy is widely used to bypass upper airway obstruction after major oral cancer surgery (MOCS). Decision to tracheostomy is frequently based on clinical scoring systems which mainly have not been validated by different cohorts. Delayed extubation in the Intensive Care Unit (ICU) may be a suitable alternative in selected cases. Read More

    Abnormally low Bispectral index and severe hypoglycemia during maintenance of and recovery from general anesthesia in diabetic retinopathy surgery: two case reports.
    BMC Anesthesiol 2018 Apr 20;18(1):45. Epub 2018 Apr 20.
    Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Tieyilu 10, Yangfangdian, Haidian District, Beijing, 100038, China.
    Background: Hypoglycemia is one of the most fatal complications during the perioperative period. General anesthesia or sedation can mask a hypoglycemia-altered mental status. Acute hypoglycemia might result in permanent brain injury. Read More

    Use, applicability and reliability of depth of hypnosis monitors in children - a survey among members of the European Society for Paediatric Anaesthesiology.
    BMC Anesthesiol 2018 Apr 16;18(1):40. Epub 2018 Apr 16.
    Department of Anaesthesiology, Erasmus University Medical Centre - Sophia Children's Hospital, Room H-1273, P.O. box 2040, 3000, CA, Rotterdam, the Netherlands.
    Background: To assess the thoughts of practicing anaesthesiologists about the use of depth of hypnosis monitors in children.

    Methods: Members of the European Society for Paediatric Anaesthesiology were invited to participate in an online survey about their thoughts regarding the use, applicability and reliability of hypnosis monitoring in children.

    Results: The survey achieved a response rate of 30% (N = 168). Read More

    Improved analgesia and reduced post-operative nausea and vomiting after implementation of an enhanced recovery after surgery (ERAS) pathway for total mastectomy.
    BMC Anesthesiol 2018 Apr 16;18(1):41. Epub 2018 Apr 16.
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 513 Parnassus Ave, S436, Box 0427, San Francisco, CA, 94143, USA.
    Background: Enhanced Recovery After Surgery (ERAS) pathways have been shown in multiple surgical disciplines to improve outcomes, including reduced opioid consumption, length of stay, and post-operative nausea and vomiting (PONV). However, very few studies describe the application of ERAS to breast surgery and even fewer describe ERAS for outpatient surgery. We describe the implementation and efficacy of an Enhanced Recovery After Surgery (ERAS) pathway for total skin-sparing mastectomy with immediate reconstruction in an outpatient setting. Read More

    Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats.
    BMC Anesthesiol 2018 Apr 16;18(1):42. Epub 2018 Apr 16.
    Department of Anesthesiology, the Third Hospital of Hebei Medical University, No. 139, Ziqiang Road, Shijiazhuang City, 050051, Hebei, China.
    Background: Calcineurin (CaN) having a high expression in hippocampal neurons is closely related to apoptosis. Pretreatment with nimodipine can lower the apoptosis rate of hippocampal neuron to reduce the incidence of postoperative cognitive dysfunction (POCD). However, the relationship between cerebral protective effect of pretreatment with nimodipine and CaN is controversial in the literature. Read More

    Advances in anesthesia technology are improving patient care, but many challenges remain.
    BMC Anesthesiol 2018 Apr 13;18(1):39. Epub 2018 Apr 13.
    Departments of Anesthesia & Health Research Methods, Evidence, and Impact, Michael DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, 1280 Main Street West Hamilton, Hamilton, ON, L8S 4L8, Canada.
    Although significant advances in clinical monitoring technology and clinical practice development have taken place in the last several decades, in this editorial we argue that much more still needs to be done. We begin by identifying many of the improvements in perioperative technology that have become available in recent years; these include electroencephalographic depth of anesthesia monitoring, bedside ultrasonography, advanced neuromuscular transmission monitoring systems, and other developments. We then discuss some of the perioperative technical challenges that remain to be satisfactorily addressed, such as products that incorporate poor software design or offer a confusing user interface. Read More

    Prospective investigation of intravenous patient-controlled analgesia with hydromorphone or sufentanil: impact on mood, opioid adverse effects, and recovery.
    BMC Anesthesiol 2018 Apr 10;18(1):37. Epub 2018 Apr 10.
    Department of Anesthesiology & Pain Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qing Chun Road, Hangzhou, Zhejiang, 310003, People's Republic of China.
    Background: Radical surgery for colorectal cancer, associated with moderate to severe postoperative pain, needs multimodal analgesia with opioid for analgesia. Despite considerable advancements, the psychological implications and other side effects with opioid remain substantially unresolved. This study aimed to investigate the impact on mood, side effects relative to opioid, and recovery of the patients with hydromorphone or sufentanil intravenous patient-controlled analgesia (IV-PCA) in a multimodal perioperative analgesia regimen undergoing radical surgery for colorectal cancer. Read More

    Dose selection of central or peripheral administration of sufentanil affect opioid induced cough?: a prospective, randomized, controlled trial.
    BMC Anesthesiol 2018 Apr 10;18(1):38. Epub 2018 Apr 10.
    Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
    Background: Opioid-induced cough (OIC) is one of the most common complications of opioids during anesthesia induction. This study was designed to assess the incidence of OIC mediated by different intravenous route.

    Methods: A total of 102(ASA I-II) scheduled for elective surgery under general anesthesia were randomly allocated into two groups: central vein group (group CV, n = 51) and peripheral vein group (group PV, n = 51). Read More

    The analgesic efficacy of subcostal transversus abdominis plane block with Mercedes incision.
    BMC Anesthesiol 2018 Apr 10;18(1):36. Epub 2018 Apr 10.
    Department of Anesthesiology and Pain Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qing Chun Road, Hangzhou, 310003, People's Republic of China.
    Background: Conventional perioperative analgesic modalities (e.g. opioids, epidural analgesia) have their own drawbacks, which limit their clinical application. Read More

    The interplay of BDNF-TrkB with NMDA receptor in propofol-induced cognition dysfunction : Mechanism for the effects of propofol on cognitive function.
    BMC Anesthesiol 2018 Apr 5;18(1):35. Epub 2018 Apr 5.
    Department of Pain, The Second Affiliated Hospital of Zhengzhou University, College of Medicine, No. 2 Jingba Road, Zhengzhou, 450003, China.
    Background: The aim of the present study was to verify whether propofol impaired learning and memory through the interplay of N-methyl-D-aspartate (NMDA) receptor with brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) signaling pathway.

    Methods: 120 Sprague-Dawley (SD) rats were randomly assigned into eight groups. Experimental drugs including saline, intralipid, propofol, N-methyl-D-aspartate (NMDA), 7,8-dihydroxyflavone (7,8-DHF), K252a and MK-801. Read More

    High-frequency power of heart rate variability can predict the outcome of thoracic surgical patients with acute respiratory distress syndrome on admission to the intensive care unit: a prospective, single-centric, case-controlled study.
    BMC Anesthesiol 2018 Apr 2;18(1):34. Epub 2018 Apr 2.
    Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
    Background: The morbidity and mortality of acute respiratory distress syndrome (ARDS) remains high, and the strategic focus of ARDS research has shifted toward identifying patients at high risk of mortality early in the course of illness. This study intended to identify the heart rate variability (HRV) measure that can predict the outcome of patients with ARDS on admission to the surgical intensive care unit (SICU).

    Methods: Patients who had lung or esophageal cancer surgery were included either in the ARDS group (n = 21) if they developed ARDS after surgery or in the control group (n = 11) if they did not. Read More

    Application of intraoperative lung-protective ventilation varies in accordance with the knowledge of anaesthesiologists: a single-Centre questionnaire study and a retrospective observational study.
    BMC Anesthesiol 2018 Apr 2;18(1):33. Epub 2018 Apr 2.
    Department of anesthesiology and Pain Medicine, anaesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
    Background: The benefits of lung-protective ventilation (LPV) with a low tidal volume (6 mL/kg of ideal body weight [IBW]), limited plateau pressure (< 28-30 cm HO), and appropriate positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome have become apparent and it is now widely adopted in intensive care units. Recently evidence for LPV in general anaesthesia has been accumulated, but it is not yet generally applied by anaesthesiologists in the operating room.

    Methods: This study investigated the perception about intraoperative LPV among 82 anaesthesiologists through a questionnaire survey and identified the differences in ventilator settings according to recognition of lung-protective ventilation. Read More

    Impedance cardiography as tool for continuous hemodynamic monitoring during cesarean section: randomized, prospective double blind study.
    BMC Anesthesiol 2018 Mar 27;18(1):32. Epub 2018 Mar 27.
    Department of Anesthesia, Intensive Care and Pain Therapy, University of Foggia, University Hospital Foggia, Foggia, Italy.
    Background: Impedance Cardiography (ICG) is a non-invasive tool for continuous hemodynamic monitoring. Aims of our study were to assess the utility of ICG to evaluate the hemodynamic impact of 6 mg (GL6) vs 8 mg (GL8) levobupivacaine combined with fentanyl in healthy patients undergoing elective cesarean section; secondary, to compare the duration and quality of analgesia and anesthesia.

    Methods: Sixty-two women receiving combined spinal-epidural (CSE) for elective cesarean delivery were randomly allocated to GL6 or GL8 groups. Read More

    The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats.
    BMC Anesthesiol 2018 Mar 27;18(1):31. Epub 2018 Mar 27.
    Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, South Korea.
    Background: Spinal cord ischemic injury remains a serious complication of open surgical and endovascular aortic procedures. Simvastatin has been reported to be associated with neuroprotective effect after spinal cord ischemia-reperfusion (IR) injury. The aim of this study was to determine the therapeutic efficacy of starting simvastatin after spinal cord IR injury in a rat model. Read More

    Experiences of ICU survivors in a low middle income country- a multicenter study.
    BMC Anesthesiol 2018 Mar 21;18(1):30. Epub 2018 Mar 21.
    Network for Improving Critical care Systems and Training, Colombo, Sri Lanka.
    Background: Stressful patient experiences during the intensive care unit (ICU) stay is associated with reduced satisfaction in High Income Countries (HICs) but has not been explored in Lower and Middle Income Countries (LMICs). This study describes the recalled experiences, stress and satisfaction as perceived by survivors of ICUs in a LMIC.

    Methods: This follow-up study was carried out in 32 state ICUs in Sri Lanka between July and December 2015. Read More

    Visual quality assessment of the liver graft by the transplanting surgeon predicts postreperfusion syndrome after liver transplantation: a retrospective cohort study.
    BMC Anesthesiol 2018 Mar 9;18(1):29. Epub 2018 Mar 9.
    Department of Anaesthesiology, Medical Faculty, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.
    Background: The discrepancy between demand and supply for liver transplants (LT) has led to an increased transplantation of organs from extended criteria donors (ECD).

    Methods: In this single center retrospective analysis of 122 cadaveric LT recipients, we investigated predictors of postreperfusion syndrome (PRS) including transplant liver quality categorized by both histological assessment of steatosis and subjective visual assessment by the transplanting surgeon using multivariable regression analysis. Furthermore, we describe the relevance of PRS during the intraoperative and postoperative course of LT recipients. Read More

    Grade III bone cement implantation syndrome in malignant lung cancer patient: a case report.
    BMC Anesthesiol 2018 Mar 2;18(1):28. Epub 2018 Mar 2.
    National Academy of Medical Sciences, National Trauma Center, Kathmandu, Nepal.
    Background: Bone cement implantation syndrome is a known complication causing mortality during perioperative period particularly in patients with malignancy. With rise in aging population with malignancy in low income country, the syndrome is more likely to be encountered.

    Case Presentation: We present a case of 66 years old male patient with metastatic bronchogenic carcinoma of lung with pathological proximal femur fracture of left hip that underwent a cemented endoprosthesis under combined spinal epidural anesthesia who succumbed to intraoperative mortality due to grade III bone cement implantation syndrome even after aggressive fluid resuscitation, vasopressor use, and mechanical ventilation. Read More

    Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial.
    BMC Anesthesiol 2018 Feb 27;18(1):27. Epub 2018 Feb 27.
    Department of Anesthesiology, Yale University, New Haven, CT, USA.
    Background: The primary goal of this study was to determine whether administration of intrathecal morphine reduces postoperative pain. The secondary goal was to determine the effect of intrathecal morphine upon circulating levels of the weakly analgesic endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and the related lipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA).

    Methods: Forty two total knee arthroplasty (TKA) patients were enrolled in a prospective, double-blinded, randomized study. Read More

    Consequences of continuing renin angiotensin aldosterone system antagonists in the preoperative period: a systematic review and meta-analysis.
    BMC Anesthesiol 2018 Feb 26;18(1):26. Epub 2018 Feb 26.
    Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, Guangdong Province, 510630, People's Republic of China.
    Background: Patients who use angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin II receptor blockers (ARBs) are prone to developing side effects like hypotension and even refractory hypotension during anesthesia use, and whether ACEIs/ARBs should be continued or discontinued in such patients remains debatable. The present systematic review and meta-analysis was conducted to clarify the consequences of continuing or withholding these drugs, especially with regards to the incidence of intraoperative hypotension, in patients who continue to use ACEIs/ARBs on the day of their scheduled surgery.

    Methods: Studies with data pertinent to the incidence of intraoperative hypotension during anesthesia use in patients who continued the use of ACEIs/ARBs on the day of their scheduled surgery were considered for inclusion. Read More

    Pre-anesthetic assessment with three core questions for the detection of obstructive sleep apnea in childhood: An observational study.
    BMC Anesthesiol 2018 Feb 20;18(1):25. Epub 2018 Feb 20.
    Department of Neuropediatric, University Hospital Leipzig, Liebigstr. 20, 04103, Leipzig, Germany.
    Background: Children with obstructive sleep apnea are at high risk for perioperative airway obstruction. Many "at risk" children may remain unrecognized. The aim of this study is to find a clinically practicable test to identify obstructive sleep apnea in childhood. Read More

    Comparative study of ultrasound-guided paravertebral block versus intravenous tramadol for postoperative pain control in percutaneous nephrolithotomy.
    BMC Anesthesiol 2018 Feb 17;18(1):24. Epub 2018 Feb 17.
    Faculty of Medicine, Department of Anaesthesiology and Reanimation, Cukurova University, 01250, Adana, Turkey.
    Background: Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure for renal calculi, and nephrostomy tubes lead to postoperative pain after PCNL. Regional techniques (e.g. Read More

    The effects of Desflurane and Sevoflurane on Nesfatin-1 levels in laparoscopic Cholecystectomy: a randomized controlled trial.
    BMC Anesthesiol 2018 Feb 16;18(1):23. Epub 2018 Feb 16.
    Yıldırım Beyazıt University Anesthesiology and Reanimation Department, Ankara, Turkey.
    Background: Nesfatin-1 is involved in cardiovascular regulation, stress-related responses. The objective of this study is to investigate the impact of volatile anesthetics on Nesfatin-1 levels.

    Method: Fourty-two patients aged 30-65 years with the American Society Anesthesiology (ASA) Class I-II who were scheduled for laparoscopic cholecystectomy were included in the study Patients were randomized into two group; desflurane administered group (Group I, n = 21) and sevoflurane administered group (Group II, n = 21). Read More

    Use of esophageal balloon pressure-volume curve analysis to determine esophageal wall elastance and calibrate raw esophageal pressure: a bench experiment and clinical study.
    BMC Anesthesiol 2018 Feb 14;18(1):21. Epub 2018 Feb 14.
    Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Address: No 6, Tiantan Xili, Dongcheng district, Beijing, 100050, China.
    Background: Accurate measurement of esophageal pressure (Pes) depends on proper filling of the balloon. Esophageal wall elastance (Ees) may also influence the measurement. We examined the estimation of balloon-surrounding elastance in a bench model and investigated a simplified calibrating procedure of Pes in a balloon with relatively small volume. Read More

    Unusual elevation in Entropy but not in PSI during general anesthesia: a case report.
    BMC Anesthesiol 2018 Feb 14;18(1):22. Epub 2018 Feb 14.
    Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul, 08308, South Korea.
    Background: EEG monitoring is useful for determining an adequate level of anesthesia. However it is sometimes interfered by various reasons. We describe a case in which we successfully confirmed the adequate depth of anesthesia by monitoring the patient state index (PSI), which was computed from the SedLine monitor data in Root (Masimo) during general anesthesia. Read More

    High-fat diet aggravates postoperative cognitive dysfunction in aged mice.
    BMC Anesthesiol 2018 Feb 13;18(1):20. Epub 2018 Feb 13.
    Department of Anesthesia, Zhongshan Hospital affiliated to Fudan University, Shanghai, China.
    Background: Silent Information Regulator 1 (Sirt1) and apoptosis play key roles in postoperative cognitive dysfunction (POCD). Consuming a high-fat diet (HFD), a prevalent type of diet in modern society, has been increasingly recognized as contributing to neurodegenerative diseases. Although Sirt1 and apoptosis are significant responders to HFD in the brain, little is known regarding the functional correlations between HFD and POCD. Read More

    Preoperative versus postoperative ultrasound-guided rectus sheath block for improving pain, sleep quality and cytokine levels in patients with open midline incisions undergoing transabdominal gynecological surgery: a randomized-controlled trial.
    BMC Anesthesiol 2018 02 9;18(1):19. Epub 2018 Feb 9.
    Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, 110001, China.
    Background: Nerve block is usually performed before surgery because it inhibits reflection of the skin incision and reduces the amount of intraoperative anesthetic used. We hypothesized that performing rectus sheath block (RSB) after surgery would result in a longer duration of the analgesic effects and have a subtle influence on sleep time after surgery but that it would not decrease the perioperative cytokine levels of patients undergoing gynecological surgery.

    Methods: A randomized, double-blinded, controlled trial was conducted from October 2015 to June 2016. Read More

    Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry - a prospectively controlled randomized double-blind clinical trial.
    BMC Anesthesiol 2018 02 9;18(1):18. Epub 2018 Feb 9.
    Klinik für Anästhesiologie, Universitätsklinik Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
    Background: Argatroban or lepirudin anticoagulation therapy in patients with heparin induced thrombocytopenia (HIT) or HIT suspect is typically monitored using the activated partial thromboplastin time (aPTT). Although aPTT correlates well with plasma levels of argatroban and lepirudin in healthy volunteers, it might not be the method of choice in critically ill patients. However, in-vivo data is lacking for this patient population. Read More

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