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    836 results match your criteria BMC Anesthesiology[Journal]

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    Pre-anesthetic assessment with three core questions for the detection of obstructive sleep apnea in childhood: An observational study.
    BMC Anesthesiol 2018 Feb 20;18(1):25. Epub 2018 Feb 20.
    Department of Neuropediatric, University Hospital Leipzig, Liebigstr. 20, 04103, Leipzig, Germany.
    Background: Children with obstructive sleep apnea are at high risk for perioperative airway obstruction. Many "at risk" children may remain unrecognized. The aim of this study is to find a clinically practicable test to identify obstructive sleep apnea in childhood. Read More

    Comparative study of ultrasound-guided paravertebral block versus intravenous tramadol for postoperative pain control in percutaneous nephrolithotomy.
    BMC Anesthesiol 2018 Feb 17;18(1):24. Epub 2018 Feb 17.
    Faculty of Medicine, Department of Anaesthesiology and Reanimation, Cukurova University, 01250, Adana, Turkey.
    Background: Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure for renal calculi, and nephrostomy tubes lead to postoperative pain after PCNL. Regional techniques (e.g. Read More

    The effects of Desflurane and Sevoflurane on Nesfatin-1 levels in laparoscopic Cholecystectomy: a randomized controlled trial.
    BMC Anesthesiol 2018 Feb 16;18(1):23. Epub 2018 Feb 16.
    Yıldırım Beyazıt University Anesthesiology and Reanimation Department, Ankara, Turkey.
    Background: Nesfatin-1 is involved in cardiovascular regulation, stress-related responses. The objective of this study is to investigate the impact of volatile anesthetics on Nesfatin-1 levels.

    Method: Fourty-two patients aged 30-65 years with the American Society Anesthesiology (ASA) Class I-II who were scheduled for laparoscopic cholecystectomy were included in the study Patients were randomized into two group; desflurane administered group (Group I, n = 21) and sevoflurane administered group (Group II, n = 21). Read More

    Use of esophageal balloon pressure-volume curve analysis to determine esophageal wall elastance and calibrate raw esophageal pressure: a bench experiment and clinical study.
    BMC Anesthesiol 2018 Feb 14;18(1):21. Epub 2018 Feb 14.
    Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Address: No 6, Tiantan Xili, Dongcheng district, Beijing, 100050, China.
    Background: Accurate measurement of esophageal pressure (Pes) depends on proper filling of the balloon. Esophageal wall elastance (Ees) may also influence the measurement. We examined the estimation of balloon-surrounding elastance in a bench model and investigated a simplified calibrating procedure of Pes in a balloon with relatively small volume. Read More

    Unusual elevation in Entropy but not in PSI during general anesthesia: a case report.
    BMC Anesthesiol 2018 Feb 14;18(1):22. Epub 2018 Feb 14.
    Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul, 08308, South Korea.
    Background: EEG monitoring is useful for determining an adequate level of anesthesia. However it is sometimes interfered by various reasons. We describe a case in which we successfully confirmed the adequate depth of anesthesia by monitoring the patient state index (PSI), which was computed from the SedLine monitor data in Root (Masimo) during general anesthesia. Read More

    High-fat diet aggravates postoperative cognitive dysfunction in aged mice.
    BMC Anesthesiol 2018 Feb 13;18(1):20. Epub 2018 Feb 13.
    Department of Anesthesia, Zhongshan Hospital affiliated to Fudan University, Shanghai, China.
    Background: Silent Information Regulator 1 (Sirt1) and apoptosis play key roles in postoperative cognitive dysfunction (POCD). Consuming a high-fat diet (HFD), a prevalent type of diet in modern society, has been increasingly recognized as contributing to neurodegenerative diseases. Although Sirt1 and apoptosis are significant responders to HFD in the brain, little is known regarding the functional correlations between HFD and POCD. Read More

    Preoperative versus postoperative ultrasound-guided rectus sheath block for improving pain, sleep quality and cytokine levels in patients with open midline incisions undergoing transabdominal gynecological surgery: a randomized-controlled trial.
    BMC Anesthesiol 2018 02 9;18(1):19. Epub 2018 Feb 9.
    Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, 110001, China.
    Background: Nerve block is usually performed before surgery because it inhibits reflection of the skin incision and reduces the amount of intraoperative anesthetic used. We hypothesized that performing rectus sheath block (RSB) after surgery would result in a longer duration of the analgesic effects and have a subtle influence on sleep time after surgery but that it would not decrease the perioperative cytokine levels of patients undergoing gynecological surgery.

    Methods: A randomized, double-blinded, controlled trial was conducted from October 2015 to June 2016. Read More

    Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry - a prospectively controlled randomized double-blind clinical trial.
    BMC Anesthesiol 2018 02 9;18(1):18. Epub 2018 Feb 9.
    Klinik für Anästhesiologie, Universitätsklinik Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
    Background: Argatroban or lepirudin anticoagulation therapy in patients with heparin induced thrombocytopenia (HIT) or HIT suspect is typically monitored using the activated partial thromboplastin time (aPTT). Although aPTT correlates well with plasma levels of argatroban and lepirudin in healthy volunteers, it might not be the method of choice in critically ill patients. However, in-vivo data is lacking for this patient population. Read More

    Comparison of lumbar plexus block using the short axis in-plane method at the plane of the transverse process and at the articular process: a randomized controlled trial.
    BMC Anesthesiol 2018 02 7;18(1):17. Epub 2018 Feb 7.
    Department of Anesthesia, the First Hospital Affiliated to Army Medical University (Southwest Hospital), Army Medical University, Chongqing, 400038, China.
    Background: Although the safety and effectiveness of the short-axis in-plane method has been confirmed for lumbar plexus block, the operation is difficult and has a high rate of epidural spread at the plane of the articular process. Therefore, we developed a new in-plane technique, called the beach chair method, which displays images from the transverse process. We compared the operative difficulty and incidence of epidural spread of the beach chair method with those of the control method (at the plane of the articular process) in this randomized controlled clinical trial. Read More

    Design of a Novel Multifunction Decision Support Display for Anesthesia Care: AlertWatch® OR.
    BMC Anesthesiol 2018 02 5;18(1):16. Epub 2018 Feb 5.
    Department of Anesthesiology, University of Michigan Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.
    Background: This paper describes the design of a multifunction alerting display for intraoperative anesthetic care. The design was inspired by the multifunction primary flight display used in modern aviation.

    Results: The display retrieves live data from multiple sources; the physiologic monitors, the anesthesia information management system, the laboratory values and comorbidities from patient's problem summary list, medical history or history & physical. Read More

    Hypertension, mitral valve disease, atrial fibrillation and low education level predict delirium and worst outcome after cardiac surgery in older adults.
    BMC Anesthesiol 2018 02 1;18(1):15. Epub 2018 Feb 1.
    Heart Institute (InCor), University of Sao Paulo, Brazil. Av. Dr. Enéas Carvalho de Aguiar 44, Sao Paulo, CEP, São Paulo, 05403-000, Brazil.
    Background: Delirium is a common complication after cardiac surgery in older adult patients. However, risk factors and the influence of delirium on patient outcomes are not well established. We aimed to determine the incidence, predisposing and triggering factors of delirium following cardiac surgery. Read More

    Perioperative incidence of airway obstructive and hypoxemic events in patients with confirmed or suspected sleep apnea - a prospective, randomized pilot study comparing propofol/remifentanil and sevoflurane/remifentanil anesthesia.
    BMC Anesthesiol 2018 01 27;18(1):14. Epub 2018 Jan 27.
    Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg-Essen and Universitätsklinikum Essen, Hufelandstr 55, D-45147, Essen, Germany.
    Background: Obstructive sleep apnea (OSA) is a risk factor for perioperative complications but data on anesthesia regimen are scarce.

    Methods: In patients with established or strongly suspected OSA, we assessed in a prospective, randomized design the effects on nocturnal apnea-hypopnea-index (AHI) and oxygen saturation (SpO) of propofol/remifentanil or sevoflurane/remifentanil based anesthesia. Patients were selected by a history for OSA and / or a positive STOP - questionnaire and received general anesthesia using remifentanil (12 μg/kg/h) combined either with propofol (4-6 mg/kg/h, n = 27) or sevoflurane (approx. Read More

    Associations between intraoperative ventilator settings during one-lung ventilation and postoperative pulmonary complications: a prospective observational study.
    BMC Anesthesiol 2018 01 25;18(1):13. Epub 2018 Jan 25.
    Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
    Background: The interest in perioperative lung protective ventilation has been increasing. However, optimal management during one-lung ventilation (OLV) remains undetermined, which not only includes tidal volume (V) and positive end-expiratory pressure (PEEP) but also inspired oxygen fraction (FO). We aimed to investigate current practice of intraoperative ventilation during OLV, and analyze whether the intraoperative ventilator settings are associated with postoperative pulmonary complications (PPCs) after thoracic surgery. Read More

    Comparison of a loading dose of dexmedetomidine combined with propofol or sevoflurane for hemodynamic changes during anesthesia maintenance: a prospective, randomized, double-blind, controlled clinical trial.
    BMC Anesthesiol 2018 01 24;18(1):12. Epub 2018 Jan 24.
    Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, No.99 Huaihai West Road, Xuzhou, 221002, Jiangsu, China.
    Background: There may be great individual variability in the hemodynamic effects of this dexmedetomidine. For this reason, the dose must be carefully adjusted to achieve the desired clinical effect. Whether a loading dose of dexmedetomidine produces hemodynamic side effects during the anesthesia maintenance is unknown. Read More

    Usefulness of a visual aid in achieving optimal positioning for spinal anesthesia: a randomized trial.
    BMC Anesthesiol 2018 01 20;18(1):11. Epub 2018 Jan 20.
    Department of Anaesthesia and Perfusion services, The Prince Charles Hospital and University of Queensland, Brisbane, Australia.
    Background: Optimal patient positioning is perceived as an essential factor to increase the success of performing neuraxial blockade. The primary objective of this study was to evaluate the benefit of using a visual image in addition to verbal instructions in order to optimize positioning for spinal block.

    Methods: This was a prospective randomized controlled trial on 85 adult patients undergoing lower limb joint replacements at a tertiary academic hospital. Read More

    Semiprone position is superior to supine position for paediatric endotracheal intubation during massive regurgitation, a randomized crossover simulation trial.
    BMC Anesthesiol 2018 01 18;18(1):10. Epub 2018 Jan 18.
    Department of Anesthesiology and Intensive Care, Stavanger University Hospital, Stavanger, Norway.
    Background: Endotracheal intubation of patients with massive regurgitation represents a challenge in emergency airway management. Gastric contents tend to block suction catheters, and few treatment alternatives exist. Based on a technique that was successfully applied in our district, we wanted to examine if endotracheal intubation would be easier and quicker to perform when the patient is turned over to a semiprone position, as compared to the supine position. Read More

    Intravenous dexmedetomidine pre-medication reduces the required minimum alveolar concentration of sevoflurane for smooth tracheal extubation in anesthetized children: a randomized clinical trial.
    BMC Anesthesiol 2018 01 17;18(1). Epub 2018 Jan 17.
    Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of WenZhou Medical University, No. 109 Xueyuan Western Road, Wenzhou, 325027, China.
    Background: It has been known that Dexmedetomidine pre-medication enhances the effects of volatile anesthetics, reduces the need of sevoflurane, and facilitates smooth extubation in anesthetized children. This present study was designed to determine the effects of different doses of intravenous dexmedetomidine pre-medication on minimum alveolar concentration of sevoflurane for smooth tracheal extubation (MAC) in anesthetized children.

    Methods: A total of seventy-five pediatric patients, aged 3-7 years, ASA physical status I and II, and undergoing tonsillectomy were randomized to receive intravenous saline (Group D), dexmedetomidine 1 μg∙kg(Group D), or dexmedetomidine 2 μg∙kg(Group D) approximately 10 min before anesthesia start. Read More

    Dexmedetomidine prevents acute kidney injury after adult cardiac surgery: a meta-analysis of randomized controlled trials.
    BMC Anesthesiol 2018 01 15;18(1). Epub 2018 Jan 15.
    Department of Intensive care unit, Beijing Shijitan Hospital, Capital Medical University, No. 10, Tieyi Road, Haidian District, Beijing, 100038, China.
    Background: Dexmedetomidine has been shown to confer direct renoprotection by stabilizing the sympathetic system, exerting anti-inflammatory effects and attenuating ischemia/reperfusion (I/R) injury in preclinical studies. Results from clinical trials of dexmedetomidine on acute kidney injury (AKI) following adult cardiac surgery are controversial.

    Methods: We searched EMBASE, PubMed, and Cochrane CENTRAL databases for randomized controlled trials (RCTs) comparing the renal effect of dexmedetomidine versus placebo or other anesthetic drugs in adult patients undergoing cardiac surgery. Read More

    Hemodynamic effects of lateral tilt before and after spinal anesthesia during cesarean delivery: an observational study.
    BMC Anesthesiol 2018 01 15;18(1). Epub 2018 Jan 15.
    Department of anesthesia and critical care, Faculty of medicine, Cairo University, 01 elsarayah Street, Elmanyal, Cairo, Egypt.
    Background: Post-spinal hypotension is a common maternal complication during cesarean delivery. Aortocaval compression by the gravid uterus has been assumed as a precipitating factor for post-spinal hypotension. The role of left lateral tilting position in improving maternal cardiac output after subarachnoid block (SAB) is unclear. Read More

    The predictive value of hunger score on gastric evacuation after oral intake of carbohydrate solution.
    BMC Anesthesiol 2018 01 12;18(1). Epub 2018 Jan 12.
    Department of Biostatistics, Shanghai Jiaotong University School of Medicine, 280 South Chongqing Road, Huangpu District, Shanghai, 200025, China.
    Background: Surgical patients are asked to fast for a sufficient duration to ensure that the amount of residual liquid in the stomach is within the safe range, thereby reducing the risk of gastric reflux perioperatively. The authors hypothesized that subjective hunger numerical rating scale (NRS) score could also help assess the process of gastric emptying and determine the amount of fluid remaining in the stomach.

    Methods: The current study consisted of healthy volunteers recruited by advertisement and mutual introduction. Read More

    Influence of isoflurane exposure in pregnant rats on the learning and memory of offsprings.
    BMC Anesthesiol 2018 01 11;18(1). Epub 2018 Jan 11.
    Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 SanHao Street, HePing District, ShenYang, Liaoning Province, People's Republic of China.
    Background: About 2% of pregnant women receive non-obstetric surgery under general anesthesia each year. During pregnancy, general anesthetics may affect brain development of the fetus. This study aimed to investigate safe dosage range of isoflurane. Read More

    Traumatic brain injury (TBI) outcomes in an LMIC tertiary care centre and performance of trauma scores.
    BMC Anesthesiol 2018 01 8;18(1). Epub 2018 Jan 8.
    Network for Improving Critical Care Systems and Training, 2nd Floor, YMBA Building, Colombo, 08, Sri Lanka.
    Background: This study evaluates post-ICU outcomes of patients admitted with moderate and severe Traumatic Brain Injury (TBI) in a tertiary neurocritical care unit in an low middle income country and the performance of trauma scores: A Severity Characterization of Trauma, Trauma and Injury Severity Score, Injury Severity Score and Revised Trauma Score in this setting.

    Methods: Adult patients directly admitted to the neurosurgical intensive care units of the National Hospital of Sri Lanka between 21st July 2014 and 1st October 2014 with moderate or severe TBI were recruited. A telephone administered questionnaire based on the Glasgow Outcome Scale Extended (GOSE) was used to assess functional outcome of patients at 3 and 6 months after injury. Read More

    Effect of single-dose dexmedetomidine on postoperative recovery after ambulatory ureteroscopy and ureteric stenting: a double blind randomized controlled study.
    BMC Anesthesiol 2018 01 5;18(1). Epub 2018 Jan 5.
    Department of Anaesthesia, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia.
    Background: Ambulatory surgery has recently gain popularity, as it is a good method of optimizinghospital resources utilization. To support ambulatory surgery, anaesthetic goals nowrevolve around patients' early recovery with minimal pain and nausea, expedientdischarge home and prompt resumption of activities of daily living. In this study, weevaluated the effect of a single pre-induction dose of dexmedetomidine on anaestheticrequirements, postoperative pain and clinical recovery after ambulatory ureteroscopy andureteric stenting under general anaesthesia. Read More

    The prevention of delirium in elderly with obstructive sleep apnea (PODESA) study: protocol for a multi-centre prospective randomized, controlled trial.
    BMC Anesthesiol 2018 01 3;18(1). Epub 2018 Jan 3.
    Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada.
    Background: Delirium is a common problem that occurs in 5-50% of elderly individuals following surgery. Patients who develop delirium after surgery are at increased risk for serious complications. Recent studies suggest that patients with obstructive sleep apnea (OSA), a sleep disorder characterized by repeated episodes of complete or partial blockage of the upper airway - are at greater risk to develop delirium. Read More

    Hemopexin promotes angiogenesis via up-regulating HO-1 in rats after cerebral ischemia-reperfusion injury.
    BMC Anesthesiol 2018 01 3;18(1). Epub 2018 Jan 3.
    Department of Anesthesiology, Tianjin Institute of Anesthesiology, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, 300052, People's Republic of China.
    Background: Ischemia-reperfusion (I/R) is a critical pathophysiological change of ischemic stroke. Heme-oxygenase-1 (HO-1) is a rate-limiting enzyme of eliminating excessive free heme by combining with hemopexin (HPX), a plasma protein contributing to alleviating infarct size due to ischemia stroke. This study was to investigate whether HPX could improve angiogenesis after cerebral ischemia-reperfusion via up-regulating HO-1. Read More

    Supreme™ laryngeal mask airway use in general Anesthesia for category 2 and 3 Cesarean delivery: a prospective cohort study.
    BMC Anesthesiol 2017 Dec 19;17(1):169. Epub 2017 Dec 19.
    Department of Women's Anaesthesia, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.
    Background: The Supreme™ laryngeal mask airway (SLMA) is a single-use LMA with double lumen design that allows separation of the respiratory and the alimentary tract, hence potentially reducing the gastric volume and risk of aspiration. The purpose of this prospective cohort study is to evaluate the the role of the SLMA as an airway technique for women undergoing category 2 and 3 Cesarean delivery under general anesthesia.

    Methods: We recruited 584 parturients who underwent category 2 or 3 Cesarean delivery under general anesthesia, in which 193 parturients underwent category 2 and 391 parturients underwent category 3 Cesarean delivery. Read More

    The beneficial use of ultramicronized palmitoylethanolamide as add-on therapy to Tapentadol in the treatment of low back pain: a pilot study comparing prospective and retrospective observational arms.
    BMC Anesthesiol 2017 Dec 19;17(1):171. Epub 2017 Dec 19.
    Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.
    Background: This pilot study was designed to compare the efficacy of ultramicronized palmitoylethanolamide (um-PEA) as add-on therapy to tapentadol (TP) with TP therapy only in patients suffering from chronic low back pain (LBP).

    Methods: This pilot observational study consists in two arms: the prospective arm and the retrospective one. In the prospective arm patients consecutively selected received um-PEA as add-on therapy to TP for 6 months; in the retrospective arm patients were treated with TP only for 6 months. Read More

    Long-duration general anesthesia influences the intelligence of school age children.
    BMC Anesthesiol 2017 Dec 19;17(1):170. Epub 2017 Dec 19.
    Department of Anesthesiology, Huashan Hospital Affiliated to Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
    Background: General anesthesia has been linked to impaired brain development in immature animals and young children. In this study the influence of orthopedic surgery under general anesthesia on the intelligence of school age children has been evaluated.

    Methods: A total of 209 subjects aged 6-12 years were recruited and allocated into 4 groups according to the duration of general anesthesia, including a control group (n = 30), short (< 1 h, n = 49), moderate- (1-3 h, n = 51) and long-duration groups (> 3 h, n = 79), respectively. Read More

    Comparison of the effect of different infusion rates of sufentanil on surgical stress index during cranial pinning in children under general anaesthesia: a randomized controlled study.
    BMC Anesthesiol 2017 Dec 8;17(1):167. Epub 2017 Dec 8.
    Department of Anaesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.
    Background: Surgical stress index (SSI) is an established indicator for intraoperative nociception. Opioids are used to block stimulus of cranial pinning in neurosurgery. We investigated the effect of different infusion rates of sufentanil on SSI during cranial pinning in children under general anaesthesia. Read More

    Neuroprotective effects of amiodarone in a mouse model of ischemic stroke.
    BMC Anesthesiol 2017 Dec 8;17(1):168. Epub 2017 Dec 8.
    Department of Anesthesiology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
    Background: Ion channels play a crucial role in the development of ischemic brain injury. Recent studies have reported that the blockade of various types of ion channels improves outcomes in experimental stroke models. Amiodarone, one of the most effective drugs for life-threatening arrhythmia, works as a multiple channel blocker and its characteristics cover all four Vaughan-Williams classes. Read More

    The ability of left ventricular end-diastolic volume variations measured by TEE to monitor fluid responsiveness in high-risk surgical patients during craniotomy: a prospective cohort study.
    BMC Anesthesiol 2017 Dec 4;17(1):165. Epub 2017 Dec 4.
    Department of Anesthesiology, West China Hospital of Sichuan University, No.37, Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
    Background: This study was aimed to evaluate the ability of left ventricular end-diastolic volume variations (LVEDVV) measured by transesophageal echocardiography (TEE) compared with stroke volume variation (SVV) obtained by the FloTrac/Vigileo monitor to predict fluid responsiveness, in patients undergoing craniotomy with goal direct therapy.

    Methods: We used SVV obtained by the FloTrac/Vigileo monitor to manage intraoperative hypotension in adult patients undergoing craniotomy (ASA III - IV) after obtaining IRB approval and informed consent. The LVEDVV were measured by TEE through the changes of left ventricular short diameter of axle simultaneously. Read More

    Effects of sevoflurane and propofol on the development of pneumonia after esophagectomy: a retrospective cohort study.
    BMC Anesthesiol 2017 Dec 4;17(1):164. Epub 2017 Dec 4.
    Department of Anesthesiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuannanli Road, Chaoyang District, Beijing, 100021, China.
    Background: Postoperative pneumonia (PP) is one of the common complications following esophagectomy and associated with poor short- and long-term outcomes. Sevoflurane and propofol, which have inflammatory-modulating effects, are common used general anesthetics. This study aimed to compare the effects of anesthesia with sevoflurane and propofol on the development of PP after esophageal surgery for cancer. Read More

    ROSC rates and live discharge rates after cardiopulmonary resuscitation by different CPR teams - a retrospective cohort study.
    BMC Anesthesiol 2017 Dec 4;17(1):166. Epub 2017 Dec 4.
    Interdepartment of Critical Care Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, South Korea.
    Background: Previous studies have reported that the quality of cardiopulmonary resuscitation (CPR) is closely associated with patient outcomes. The aim of this study was to compare patient CPR outcomes across resident, emergency medicine, and rapid response teams.

    Methods: The records of patients who underwent CPR at the Seoul National University Bundang Hospital from January 1, 2013 to December 31, 2016 were analyzed retrospectively. Read More

    Perioperative Duloxetine and Etoricoxibto improve postoperative pain after lumbar Laminectomy: a randomized, double-blind, controlled study.
    BMC Anesthesiol 2017 Dec 2;17(1):162. Epub 2017 Dec 2.
    Departments of Anesthesiology and I.C.U Al-Minia University, Faculty of Medicine, Minia University, Minia, 61111, Egypt.
    Background: Duloxetine, Etoricoxib and opioid are of the commonly administered drugs in Lumbar laminectomy. The aim of this study is to assess the effect of perioperative use of Duloxetine in combination with Etoricoxib on postoperative pain and opioid requirements.

    Methods: One hundred twenty patients with ASA physical status were enrolled with age between 18 and 70 years. Read More

    Clinical significance and risk factors for new onset and recurring atrial fibrillation following cardiac surgery - a retrospective data analysis.
    BMC Anesthesiol 2017 Dec 2;17(1):163. Epub 2017 Dec 2.
    Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.
    Background: Although mortality after cardiac surgery has significantly decreased in the last decade, patients still experience clinically relevant postoperative complications. Among others, atrial fibrillation (AF) is a common consequence of cardiac surgery, which is associated with prolonged hospitalization and increased mortality.

    Methods: We retrospectively analyzed data from patients who underwent coronary artery bypass grafting, valve surgery or a combination of both at the University Hospital Muenster between April 2014 and July 2015. Read More

    Dose-response studies of Ropivacaine in blood flow of upper extremity after supraclavicular block: a double-blind randomized controlled study.
    BMC Anesthesiol 2017 Dec 2;17(1):161. Epub 2017 Dec 2.
    Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan, China.
    Background: The sympathetic block of upper limb leading to increased blood flow has important clinical implication in microvascular surgery. However, little is known regarding the relationship between concentration of local anesthetic and blood flow of upper limb. The aim of this dose-response study was to determine the EDand EDof ropivacaine in blood flow after supraclavicular block (SB). Read More

    Correction to: Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy.
    BMC Anesthesiol 2017 11 30;17(1):159. Epub 2017 Nov 30.
    Clinical Research, Menarini Ricerche S.p.A - Menarini Group, Florence, Italy.
    Correction: Following publication of the original article [1], the authors reported that additional file 10 contained a typing error in the table "Percentage of responders (≥50% max TOTPAR) over two, four, six and eight hours (single-dose phase) (ITT Population)". The table is to be read as follows. Read More

    The usefulness of the McGrath MAC laryngoscope in comparison with Airwayscope and Macintosh laryngoscope during routine nasotracheal intubation: a randomaized controlled trial.
    BMC Anesthesiol 2017 Dec 1;17(1):160. Epub 2017 Dec 1.
    Department of Anesthesiology and Intensive Care Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
    Background: McGrath MAC video laryngoscope offers excellent laryngosopic views and increases the success rate of orotracheal intubation in some cases. The aim of this study was to determine the usefulness of McGrath MAC for routine nasotracheal intubation by comparing McGrath MAC with Airway scope and Macintosh laryngoscope.

    Methods: A total of 60 adult patients with ASA physical status class 1 or 2, aged 20-70 years were enrolled in this study. Read More

    Pediatric premedication: a double-blind randomized trial of dexmedetomidine or ketamine alone versus a combination of dexmedetomidine and ketamine.
    BMC Anesthesiol 2017 Nov 29;17(1):158. Epub 2017 Nov 29.
    Department of Anesthesiology, The Eye, Ear, Nose and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
    Background: Preoperative anxiety is common in pediatric patients. When dexmedetomidine is used alone for sedation as premedication, children tend to awaken when separated from their parents, and body movements occur during invasive procedures. We tested the hypothesis that the combination of dexmedetomidine and ketamine may be a useful premedication to alleviate preoperative anxiety and improve cooperation during intravenous cannulation in pediatric patients, while producing minimal adverse events. Read More

    Capnography sensor use is associated with reduction of adverse outcomes during gastrointestinal endoscopic procedures with sedation administration.
    BMC Anesthesiol 2017 Nov 28;17(1):157. Epub 2017 Nov 28.
    Health Economics and Outcomes Research, Medtronic, Mansfield, MA, USA.
    Background: Evidence to date suggests that capnography monitoring during gastrointestinal endoscopic procedures (GEP) reduces the incidence of hypoxemia, but the association of capnography monitoring with the incidence of other adverse outcomes surrounding these procedures has not been well studied. Our aims were to estimate the incidence of pharmacological rescue events and death at discharge from an inpatient or outpatient hospitalization where GEP was performed with sedation, and to determine if capnography monitoring was associated with reduced incidence of these adverse outcomes.

    Methods: This retrospective Premier Database analysis included medical inpatients and all outpatients undergoing GEP with sedation. Read More

    The optimum sevoflurane concentration for supraglottic airway device Blockbuster™ insertion with spontaneous breathing in obese patients: a prospective observational study.
    BMC Anesthesiol 2017 Nov 28;17(1):156. Epub 2017 Nov 28.
    Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Background: Airway management of the obese patient presenting for surgery is more likely to be a challenging problem. Supraglottic airway device has been adopted as a bridge to connect ventilation and tracheal intubation in obese patients who would be suffered with difficult intubation. The optimum sevoflurane concentration for supraglottic airway device insertion allowing spontaneous breathing in 50% of obese patients (ED) is not known. Read More

    Low flow extracorporeal COremoval in ARDS patients: a prospective short-term crossover pilot study.
    BMC Anesthesiol 2017 Nov 28;17(1):155. Epub 2017 Nov 28.
    Intensive Care Unit, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
    Background: Lung protective mechanical ventilation (MV) is the corner stone of therapy for ARDS. However, its use may be limited by respiratory acidosis. This study explored feasibility of, effectiveness and safety of low flow extracorporeal COremoval (ECCOR). Read More

    A single dose of dezocine suppresses emergence agitation in preschool children anesthetized with sevoflurane-remifentanil.
    BMC Anesthesiol 2017 Nov 22;17(1):154. Epub 2017 Nov 22.
    Department of Anesthesiology, Shanghai General Hospital of Nanjing Medical University, University, No. 100 Haining Road, Shanghai, 200030, China.
    Background: Emergence agitation (EA) is a common phenomenon in preschool children during emergence from general anesthesia. This study evaluated the safety and efficacy of dezocine for emergence agitation in preschool children anesthetized with sevoflurane-remifentanil.

    Methods: A total of 100 preschool children, scheduled for elective laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia were randomized into two groups: Group C (n = 50) received Ringer's lactate 10 mL and Group D received Ringer's lactate 10 mL containing dezocine 0. Read More

    Observations on significant hemodynamic changes caused by a high concentration of epidurally administered ropivacaine: correlation and prediction study of stroke volume variation and central venous pressure in thoracic epidural anesthesia.
    BMC Anesthesiol 2017 Nov 16;17(1):153. Epub 2017 Nov 16.
    Department of Anesthesia and Pain Medicine, Pusan National University Hospital, 179 Gudeok-Ro, Seo-Gu, Busan, 602739, South Korea.
    Background: Thoracic epidural anesthesia (TEA) exacerbates hypotension due to peripheral vasodilator effects following the use of general anesthetics. This study aimed to compare the hemodynamic changes caused by three different concentrations of epidural ropivacaine and to evaluate the performance of the stroke-volume variation (SVV) and central venous pressure (CVP) during TEA with general anesthesia.

    Methods: A total of 120 patients were administered 8 mL of ropivacaine solution via epidural injection, following randomization into one of three groups based on the concentration of ropivacaine in the study solution: 0. Read More

    Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice.
    BMC Anesthesiol 2017 Nov 13;17(1):152. Epub 2017 Nov 13.
    Department of Physiology, College of Medicine, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
    Background: Previous studies have shown that cyclooxygenase-2, a key enzyme that converts arachidonic acid to prostaglandins, is involved in anxiety and cognitive processes, but few studies have investigated the effects of chronic administration of cyclooxygenase-2 inhibitors on anxiety, learning and memory under normal physiological conditions. The aim of the study was to investigate the effects of chronic administration of parecoxib, a cyclooxygenase-2 inhibitor, on anxiety behavior and memory performance under normal physiological conditions and to explore the possible neural mechanism underlying parecoxib-mediated effects.

    Methods: Adult male ICR mice were randomly divided into four groups: the control group and three parecoxib groups. Read More

    Mechanical strain to maxillary incisors during direct laryngoscopy.
    BMC Anesthesiol 2017 Nov 7;17(1):151. Epub 2017 Nov 7.
    Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA.
    Background: While most Direct laryngoscopy leads to dental injury in 25-39% of cases. Dental injury occurs when the forces and impacts applied to the teeth exceed the ability of the structures to dissipate energy and stress. The purpose of this study was to measure strain, (which is the change produced in the length of the tooth by a force applied to the tooth) strain rate, and strain-time integral to the maxillary incisors and determine if they varied by experience, type of blade, or use of an alcohol protective pad (APP). Read More

    Membrane protein Nav1.7 contributes to the persistent post-surgical pain regulated by p-p65 in dorsal root ganglion (DRG) of SMIR rats model.
    BMC Anesthesiol 2017 Nov 7;17(1):150. Epub 2017 Nov 7.
    Department of Anesthesiology, the First Affiliated Hospital, Zhengzhou University, No 1, Jianshe Road, Zhengzhou, 450052, People's Republic of China.
    Background: Persistent post-surgical pain is a difficult clinical problem. In this study, we intend to explore the mechanism underlying the persistent post-surgical pain in SMIR (skin/muscle incision and retraction) rats.

    Methods: First of all, the expression of membrane protein Nav1. Read More

    Effects of lung protective mechanical ventilation associated with permissive respiratory acidosis on regional extra-pulmonary blood flow in experimental ARDS.
    BMC Anesthesiol 2017 Oct 27;17(1):149. Epub 2017 Oct 27.
    Department of Anesthesia and Intensive Care Medicine, University Hospital of Bonn, Bonn, Germany.
    Background: Lung protective mechanical ventilation with limited peak inspiratory pressure has been shown to affect cardiac output in patients with ARDS. However, little is known about the impact of lung protective mechanical ventilation on regional perfusion, especially when associated with moderate permissive respiratory acidosis. We hypothesized that lung protective mechanical ventilation with limited peak inspiratory pressure and moderate respiratory acidosis results in an increased cardiac output but unequal distribution of blood flow to the different organs of pigs with oleic-acid induced ARDS. Read More

    Propofol inhibits the release of interleukin-6, 8 and tumor necrosis factor-α correlating with high-mobility group box 1 expression in lipopolysaccharides-stimulated RAW 264.7 cells.
    BMC Anesthesiol 2017 Oct 26;17(1):148. Epub 2017 Oct 26.
    Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
    Background: Studies have found that propofol can inhibit endotoxin-induced monocyte-macrophages to produce various inflammatory factors. This study is to disclose whether the propofol affects the expression of high-mobility group box 1 (HMGB1) in lipopolysaccharides (LPS)-stimulated RAW 264.7 cells and the release of interleukin-6 (IL-6), 8 (IL-8) and tumor necrosis factor-α (TNF-α). Read More

    The obesity conundrum in sepsis.
    BMC Anesthesiol 2017 Oct 25;17(1):147. Epub 2017 Oct 25.
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA.
    While the long-term negative effects of obesity on health is a well-studied phenomenon, its effects on acute illnesses seem to be the contrary. Several studies have indicated the possibility of an 'obesity paradox' in sepsis - where overweight and obese patients have better outcomes than normal weight patients. These meta-analyses including large numbers of patients across different countries raised an interesting but debatable topic. Read More

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