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    793 results match your criteria BMC Anesthesiology[Journal]

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    Observations on significant hemodynamic changes caused by a high concentration of epidurally administered ropivacaine: correlation and prediction study of stroke volume variation and central venous pressure in thoracic epidural anesthesia.
    BMC Anesthesiol 2017 Nov 16;17(1):153. Epub 2017 Nov 16.
    Department of Anesthesia and Pain Medicine, Pusan National University Hospital, 179 Gudeok-Ro, Seo-Gu, Busan, 602739, South Korea.
    Background: Thoracic epidural anesthesia (TEA) exacerbates hypotension due to peripheral vasodilator effects following the use of general anesthetics. This study aimed to compare the hemodynamic changes caused by three different concentrations of epidural ropivacaine and to evaluate the performance of the stroke-volume variation (SVV) and central venous pressure (CVP) during TEA with general anesthesia.

    Methods: A total of 120 patients were administered 8 mL of ropivacaine solution via epidural injection, following randomization into one of three groups based on the concentration of ropivacaine in the study solution: 0. Read More

    Chronic administration of parecoxib exerts anxiolytic-like and memory enhancing effects and modulates synaptophysin expression in mice.
    BMC Anesthesiol 2017 Nov 13;17(1):152. Epub 2017 Nov 13.
    Department of Physiology, College of Medicine, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
    Background: Previous studies have shown that cyclooxygenase-2, a key enzyme that converts arachidonic acid to prostaglandins, is involved in anxiety and cognitive processes, but few studies have investigated the effects of chronic administration of cyclooxygenase-2 inhibitors on anxiety, learning and memory under normal physiological conditions. The aim of the study was to investigate the effects of chronic administration of parecoxib, a cyclooxygenase-2 inhibitor, on anxiety behavior and memory performance under normal physiological conditions and to explore the possible neural mechanism underlying parecoxib-mediated effects.

    Methods: Adult male ICR mice were randomly divided into four groups: the control group and three parecoxib groups. Read More

    Mechanical strain to maxillary incisors during direct laryngoscopy.
    BMC Anesthesiol 2017 Nov 7;17(1):151. Epub 2017 Nov 7.
    Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA.
    Background: While most Direct laryngoscopy leads to dental injury in 25-39% of cases. Dental injury occurs when the forces and impacts applied to the teeth exceed the ability of the structures to dissipate energy and stress. The purpose of this study was to measure strain, (which is the change produced in the length of the tooth by a force applied to the tooth) strain rate, and strain-time integral to the maxillary incisors and determine if they varied by experience, type of blade, or use of an alcohol protective pad (APP). Read More

    Membrane protein Nav1.7 contributes to the persistent post-surgical pain regulated by p-p65 in dorsal root ganglion (DRG) of SMIR rats model.
    BMC Anesthesiol 2017 Nov 7;17(1):150. Epub 2017 Nov 7.
    Department of Anesthesiology, the First Affiliated Hospital, Zhengzhou University, No 1, Jianshe Road, Zhengzhou, 450052, People's Republic of China.
    Background: Persistent post-surgical pain is a difficult clinical problem. In this study, we intend to explore the mechanism underlying the persistent post-surgical pain in SMIR (skin/muscle incision and retraction) rats.

    Methods: First of all, the expression of membrane protein Nav1. Read More

    Effects of lung protective mechanical ventilation associated with permissive respiratory acidosis on regional extra-pulmonary blood flow in experimental ARDS.
    BMC Anesthesiol 2017 Oct 27;17(1):149. Epub 2017 Oct 27.
    Department of Anesthesia and Intensive Care Medicine, University Hospital of Bonn, Bonn, Germany.
    Background: Lung protective mechanical ventilation with limited peak inspiratory pressure has been shown to affect cardiac output in patients with ARDS. However, little is known about the impact of lung protective mechanical ventilation on regional perfusion, especially when associated with moderate permissive respiratory acidosis. We hypothesized that lung protective mechanical ventilation with limited peak inspiratory pressure and moderate respiratory acidosis results in an increased cardiac output but unequal distribution of blood flow to the different organs of pigs with oleic-acid induced ARDS. Read More

    Propofol inhibits the release of interleukin-6, 8 and tumor necrosis factor-α correlating with high-mobility group box 1 expression in lipopolysaccharides-stimulated RAW 264.7 cells.
    BMC Anesthesiol 2017 Oct 26;17(1):148. Epub 2017 Oct 26.
    Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
    Background: Studies have found that propofol can inhibit endotoxin-induced monocyte-macrophages to produce various inflammatory factors. This study is to disclose whether the propofol affects the expression of high-mobility group box 1 (HMGB1) in lipopolysaccharides (LPS)-stimulated RAW 264.7 cells and the release of interleukin-6 (IL-6), 8 (IL-8) and tumor necrosis factor-α (TNF-α). Read More

    The obesity conundrum in sepsis.
    BMC Anesthesiol 2017 Oct 25;17(1):147. Epub 2017 Oct 25.
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA.
    While the long-term negative effects of obesity on health is a well-studied phenomenon, its effects on acute illnesses seem to be the contrary. Several studies have indicated the possibility of an 'obesity paradox' in sepsis - where overweight and obese patients have better outcomes than normal weight patients. These meta-analyses including large numbers of patients across different countries raised an interesting but debatable topic. Read More

    Assessment of Haemostasis in patients undergoing emergent neurosurgery by rotational Elastometry and standard coagulation tests: a prospective observational study.
    BMC Anesthesiol 2017 Oct 24;17(1):146. Epub 2017 Oct 24.
    Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, -1211, Geneva, CH, Switzerland.
    Background: Rotational elastometry (ROTEM) has been shown useful to monitor coagulation in trauma patients and in major elective surgery. In this study, we aimed to evaluate the utility of ROTEM to identify hemostatic disturbances and to predict the need for transfusion, compared with standard coagulation tests (SCTs) in patients undergoing emergent neurosurgery.

    Methods: Over a four-year period, adult patients who met criteria for emergent neurosurgery lasting more than 90 min were included in the study. Read More

    Computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in endotoxin-induced shock.
    BMC Anesthesiol 2017 Oct 23;17(1):145. Epub 2017 Oct 23.
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, 565-8565, Japan.
    Background: Hemodynamic resuscitation in septic shock requires aggressive fluid replacement and appropriate use of vasopressors to optimize arterial pressure (AP) and cardiac output (CO). Because responses to these drugs vary between patients and within patient over time, strict monitoring of patient condition and repetitive adjustment of drug dose are required. This task is time and labor consuming, and is associated with poor adherence to resuscitation guidelines. Read More

    Effect of interscalene block on intraocular pressure and ocular perfusion pressure.
    BMC Anesthesiol 2017 Oct 23;17(1):144. Epub 2017 Oct 23.
    Department of Orthopedics and Traumatology, Konya Training and Research Hospital, Konya, Turkey.
    Background: Interscalene block (ISB) is commonly associated with Horner's syndrome due to spread of local anesthetic to the cervical sympathetic chain. Postganglionic neurons that originate from superior cervical ganglia form the sympathetic innervation of eye. Decrease in sympathetic tone may change intraocular pressure (IOP) and ocular perfusion pressure (OPP). Read More

    Perioperative management of paraganglioma and catecholamine-induced cardiomyopathy in child- a case report and review of the literature.
    BMC Anesthesiol 2017 Oct 17;17(1):142. Epub 2017 Oct 17.
    Department of Anesthesiology, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, People's Republic of China.
    Background: Paragangliomas are catecholamine-secreting tumors of the paraganglia. Perioperative mortality of children with paraganglioma is high, but preoperative therapy and anesthetic management of paraganglioma resection are controversial in children. The literatures on catecholamine-induced cardiomyopathy are limited to several case reports,with few reports of studies on children. Read More

    Intraoperative continuous cerebral microcirculation measurement in patients with aneurysmal subarachnoid hemorrhage: preliminary data on the early administration of magnesium sulfate.
    BMC Anesthesiol 2017 Oct 17;17(1):143. Epub 2017 Oct 17.
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstraße 12, 91054, Erlangen, Germany.
    Background: In patients with subarachnoid hemorrhage (SAH), vasospasm remains one of the major complications. The application of intravenous magnesium sulfate (MgSO4) has been under discussion to prevent cerebral ischemia. Our aim was to examine the impact of early MgSO4 administration on local cerebral microcirculation during microsurgical clipping of SAH-related aneurysms. Read More

    Preparing for the unexpected: special considerations and complications after sugammadex administration.
    BMC Anesthesiol 2017 Oct 17;17(1):140. Epub 2017 Oct 17.
    Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, Florida, 32224, USA.
    Sugammadex, a modified gamma-cyclodextrin, has changed clinical practice of neuromuscular reversal dramatically. With the introduction of this selective relaxant binding agent, rapid and reliable neuromuscular reversal from any depth of block became possible. Sugammadex can reverse neuromuscular blockade without the muscarinic side effects typically associated with the administration of acetylcholinesterase inhibitors. Read More

    Role of tube size and intranasal compression of the nasotracheal tube in respiratory pressure loss during nasotracheal intubation: a laboratory study.
    BMC Anesthesiol 2017 Oct 17;17(1):141. Epub 2017 Oct 17.
    Department of Anesthesiology, Nara Hospital, Kindai University Faculty of Medicine, 1248-1 Otodacho, Ikoma, Nara, 630-0293, Japan.
    Background: Small nasotracheal tubes (NTTs) and intranasal compression of the NTT in the nasal cavity may contribute to increasing airway resistance. Since the effects of size, shape, and partial compression of the NTT on airway resistance have not been investigated, values of airway resistance with partial compression of preformed NTTs of various sizes were determined.

    Methods: To determine the factors affecting the respiratory pressure loss during the nasotracheal intubation, physical and fluid dynamics simulations were used. Read More

    Gastrointestinal motility following thoracic surgery: the effect of thoracic epidural analgesia. A randomised controlled trial.
    BMC Anesthesiol 2017 Oct 16;17(1):139. Epub 2017 Oct 16.
    Faculty of Medicine, University of Crete, Stavrakia, 71003, Heraklion, Greece.
    Backgrounds: Impairment of gastrointestinal (GI) motility is an undesirable but inevitable consequence of surgery. This prospective randomised controlled study tested the hypothesis that postoperative thoracic epidural analgesia (TEA) with ropivacaine or a combination of ropivacaine and morphine accelerates postoperative GI function and shortens the duration of postoperative ileus following major thoracic surgery compared to intravenous (IV) morphine.

    Methods: Thirty patients scheduled for major thoracic surgery were randomised to three groups. Read More

    Staggering the dose of sugammadex lowers risks for severe emergence cough: a randomized control trial.
    BMC Anesthesiol 2017 Oct 11;17(1):137. Epub 2017 Oct 11.
    Julius Centre University of Malaya, Department of Social & Preventive Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
    Background: Cough on emergence has been reported as a common adverse reaction with sugammadex reversal. We investigated if staggering the dose of sugammadex will reduce emergence cough in a single-center, randomized, double-blinded study.

    Methods: A hundred and twenty ASA 1-3 adults were randomly reversed with 1 mg/kg sugammadex prior to extubation followed by another 1 mg/kg immediately after extubation (staggered group), single dose of 2 mg/kg sugammadex (single bolus group) or neostigmine 0. Read More

    A comparison of the use of propofol alone and propofol with midazolam for pediatric magnetic resonance imaging sedation - a retrospective cohort study.
    BMC Anesthesiol 2017 Oct 11;17(1):138. Epub 2017 Oct 11.
    Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University school of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul, 06351, Korea.
    Background: Pediatric MRI sedation performed by a variety of specialists such as sedationists and anesthesiologists commonly uses propofol, which has similar effects to an ideal sedative agent for maintaining deep sedation. However, when propofol is used, adverse airway events are relatively more common than when using other sedative agents. The concomitant administration of midazolam and propofol can reduce the dose of propofol needed for adequate sedation and might also reduce the frequency of airway obstruction without affecting the patient's recovery profile. Read More

    The EC90 of remifentanil for blunting cardiovascular responses to head fixation for neurosurgery under total intravenous anesthesia with propofol and remifentanil based on bispectral index monitoring: estimation with the biased coin up-and-down sequential method.
    BMC Anesthesiol 2017 Oct 10;17(1):136. Epub 2017 Oct 10.
    Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
    Background: Head fixation can induce hemodynamic instability. Remifentanil is commonly used with propofol for total intravenous anesthesia (TIVA) during neurosurgery. This study investigated the 90% effective concentration (EC90) of remifentanil for blunting of cardiovascular responses to head fixation during neurosurgery via bispectral index (BIS) monitoring. Read More

    Acute transient spinal paralysis and cardiac symptoms following an accidental epidural potassium infusion - a case report.
    BMC Anesthesiol 2017 Oct 6;17(1):135. Epub 2017 Oct 6.
    Treatment Centre for Spinal Cord Injuries, Trauma Hospital Berlin, Warener Straße 7, 12683, Berlin, Germany.
    Background: To describe a case of an accidental epidural potassium infusion leading to an acute transient spinal paralysis and cardiac symptoms and review the literature on that topic.

    Case Presentation: We report the case of an accidental infusion of 900 mg potassium chloride 7.45% (KCl) into the epidural space, which occurred during epidural analgesia in a 74-year-old patient suffering from immobilization due to lumbar back pain as well as from a paralytic Ileus. Read More

    Patients with glycogen storage diseases undergoing anesthesia: a case series.
    BMC Anesthesiol 2017 Oct 6;17(1):134. Epub 2017 Oct 6.
    Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
    Background: Glycogen storage diseases are rare genetic disorders of glycogen synthesis, degradation, or metabolism regulation. When these patients are subjected to anesthesia, perioperative complications can develop, including hypoglycemia, rhabdomyolysis, myoglobinuria, acute renal failure, and postoperative fatigue. The objective of this study was to describe the perioperative course of a cohort of patients with glycogen storage diseases. Read More

    Bougies as an aid for endotracheal intubation with the Airway Scope: bench and manikin comparison studies.
    BMC Anesthesiol 2017 Oct 2;17(1):133. Epub 2017 Oct 2.
    Department of Anesthesia, Kyushu Rosai Hospital, 1-1 Sonekita, Kokuraminami, Kitakyushu, 800-0296, Japan.
    Background: When encountering a difficult airway with an Airway Scope (AWS) a bougie can be inserted into the endotracheal tube in the AWS channel. The angulated tip of the bougie can be guided toward the glottis by rotating it. We tested the ease of rotating bougies (Venn reusable, Boussignac, Portex single-use, and Frova) in an endotracheal tube when placed in the AWS channel. Read More

    Propofol enhances BCR-ABL TKIs' inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression.
    BMC Anesthesiol 2017 Sep 29;17(1):132. Epub 2017 Sep 29.
    Department of Anesthesiology, Fifth Affiliated Hospital, Southern Medical University, Congcheng Road No. 566, Conghua district, Guangzhou, Guangdong province, 510900, China.
    Background: The anti-cancer activities of intravenous anesthetic drug propofol have been demonstrated in various types of cancers but not in chronic myeloid leukemia (CML).

    Methods: We systematically examined the effect of propofol and its combination with BCR-ABL tyrosine kinase inhibitors (TKIs) in CML cell lines, patient progenitor cells and mouse xenograft model. We analyzed propofol's underlying mechanism focusing on survival pathway in CML cells. Read More

    Validation of the imperial college surgical assessment device for spinal anesthesia.
    BMC Anesthesiol 2017 Sep 29;17(1):131. Epub 2017 Sep 29.
    Anesthesiology Department, School of Medicine, Pontificia Universidad Catolica de Chile, Marcoleta 367, 8330024, Santiago, Chile.
    Background: Traditionally, technical proficiency for spinal anesthesia has been assessed using observational scales such as global rating scales or task specific checklists. However more objective metrics are required in order to improve novice's training programs. The aim of this study is to validate the hand motion analysis of the Imperial College Surgical Assessment Device (ICSAD) in a simulated model of spinal anesthesia. Read More

    Effects of dexmedetomidine on TNF-α and interleukin-2 in serum of rats with severe craniocerebral injury.
    BMC Anesthesiol 2017 Sep 20;17(1):130. Epub 2017 Sep 20.
    Department of Anesthesiology II, Affiliated Zhongshan Hospital of Dalian University, No. 6 of Jiefang Street, Zhongshan District, Dalian, 116001, China.
    Background: Dexmedetomidine is a highly selective adrenergic receptor agonist, which has a dose-dependent sedative hypnotic effect. Furthermore, it also has pharmacological properties, and the ability to inhibit sympathetic activity and improve cardiovascular stability during an operation. However, its protective effect on patients with severe craniocerebral injury in the perioperative period remains unclear. Read More

    Effects of lubrication on air-sealing performance of a pediatric cuffed tracheal tube.
    BMC Anesthesiol 2017 Sep 19;17(1):129. Epub 2017 Sep 19.
    Department of Anesthesiology, Mizonokuchi Hospital, Teikyo University School of Medicine, 3-8-3 Mizonokuchi, Takatsu-ku, Kawasaki, 213-8507, Japan.
    Background: Lubrication of cuffed tracheal tubes (CTTs) reduces liquid leakage. However, it is not clear how cuff lubrication influences air leakage. We aimed to test the hypothesis that pretreatment with K-Y jelly, a water-soluble lubricant, would improve the air-sealing performance of pediatric CTTs in a model study. Read More

    Levosimendan combined with epinephrine improves rescue outcomes in a rat model of lipid-based resuscitation from bupivacaine-induced cardiac arrest.
    BMC Anesthesiol 2017 Sep 15;17(1):128. Epub 2017 Sep 15.
    Department of Anaesthesiology, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang, China.
    Background: The effectiveness of a combination of a lipid emulsion with epinephrine in reversing local anesthetic-induced cardiac arrest has been confirmed. The combination of a lipid emulsion with levosimendan, was shown to be superior to administration of a lipid emulsion alone with regard to successful resuscitation. In this study, we compared the reversal effects of levosimendan, epinephrine, and a combination of the two agents in lipid-based resuscitation in a rat model of bupivacaine-induced cardiac arrest. Read More

    Incidence and severity of postoperative sore throat: a randomized comparison of Glidescope with Macintosh laryngoscope.
    BMC Anesthesiol 2017 Sep 12;17(1):127. Epub 2017 Sep 12.
    Department of Anesthesiology, King Khalid Hospital, Hail, Saudi Arabia.
    Background: Postoperative sore throat (POST) is a common problem following endotracheal (ET) intubation during general anesthesia. The objective was to compare the incidence and severity of POST during routine intubation with Glidescope (GL) and Macintosh laryngoscope (MCL).

    Methods: One hundred forty adult patients ASA I and II with normal airway, scheduled to undergo elective surgery under GA requiring ET intubation were enrolled in this prospective randomized study and were randomly divided in two groups, GL and MCL. Read More

    Determination of the optimal inspiratory pressure providing adequate ventilation while minimizing gastric insufflation using real-time ultrasonography in Chinese children: a prospective, randomized, double-blind study.
    BMC Anesthesiol 2017 Sep 11;17(1):126. Epub 2017 Sep 11.
    Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children Hospital of Wenzhou Medical University, West College Road 109, Wenzhou, 325027, China.
    Background: During facemask ventilation, gastric insufflation is defined as appearance of a comet-tail or an acoustic shadow on ultrasonography. Ultrasonographic measurement of antral cross-section area (CSA) may reflect an insufflated antrum and provide interesting semi-quantitative data in regard to the gastric insufflation. This study aimed to determine the appropriate level of inspiratory pressure sufficient to provide adequate pulmonary ventilation with a lower occurrence of gastric insufflation during facemask pressure-controlled ventilation using real-time ultrasonography in paralyzed children. Read More

    Comparison of the Supreme™ and ProSeal™ laryngeal mask airways in infants: a prospective randomised clinical study.
    BMC Anesthesiol 2017 Sep 5;17(1):125. Epub 2017 Sep 5.
    Department of Paediatric Surgery, Sisli Hamidiye Etfal Education and Research Hospital, Halaskargazi Cad., Etfal Sok, 34377, Istanbul, Turkey.
    Background: The Supreme™ and ProSeal™ laryngeal mask airways (LMAs) are widely used in paediatric anaesthesia; however, LMA use in infants is limited because many anaesthesiologists prefer to use tracheal intubation in infants. In this study, we compared the Supreme and ProSeal LMAs in infants by measuring their performance characteristics, including insertion features, ventilation parameters, induced changes in haemodynamics and rates of postoperative complications.

    Methods: Infants of ASA physical status I scheduled for elective, minor, lower abdominal surgery were divided into two groups: the Supreme LMA group and the ProSeal LMA group. Read More

    TREK-1 mediates isoflurane-induced cytotoxicity in astrocytes.
    BMC Anesthesiol 2017 Sep 5;17(1):124. Epub 2017 Sep 5.
    Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
    Background: There are growing concerns that anaesthetic exposure can cause extensive apoptotic degeneration of neurons and the impairment of normal synaptic development and remodelling. However, little attention has been paid to exploring the possible cytotoxicity of inhalation anaesthetics, such as isoflurane, in astrocytes. In this research, we determined that prolonged exposure to an inhalation anaesthetic caused cytotoxicity in astrocytes, and we identified the underlying molecular mechanism responsible for this process. Read More


    Ten important articles on noninvasive ventilation in critically ill patients and insights for the future: A report of expert opinions.
    BMC Anesthesiol 2017 Sep 4;17(1):122. Epub 2017 Sep 4.
    Department of Biopathology and Medical Biotechnologies (DIBIMED). Section of Anestesia, Analgesia, Intensive Care and Emergency, Policlinico P. Giaccone, University of Palermo, Palermo, Italy.
    Background: Noninvasive ventilation is used worldwide in many settings. Its effectiveness has been proven for common clinical conditions in critical care such as cardiogenic pulmonary edema and chronic obstructive pulmonary disease exacerbations. Since the first pioneering studies of noninvasive ventilation in critical care in the late 1980s, thousands of studies and articles have been published on this topic. Read More

    Hydrogen sulfide attenuates isoflurane-induced neuroapoptosis and cognitive impairment in the developing rat brain.
    BMC Anesthesiol 2017 Sep 5;17(1):123. Epub 2017 Sep 5.
    Department of Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, No. 600 of Changjiang Road, Xiangfang District, Harbin, Heilongjiang Province, China.
    Background: Isoflurane-induced neuroapoptosis and cognitive impairment has been previously reported. Hydrogen sulfide (H2S) has been shown to be a neuromodulator that is thought to have anti-apoptotic, anti-inflammatory, and anti-oxidative benefits. However, it is not known if H2S is protective against anesthesia-induced apoptosis and cognitive defects. Read More

    Pediatric supraglottic airway devices in clinical practice: A prospective observational study.
    BMC Anesthesiol 2017 Sep 2;17(1):119. Epub 2017 Sep 2.
    Department of Anaesthesiology and Pain Therapy, Inselspital, University Hospital Bern, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
    Background: Supraglottic airway devices (SGA) are commonly used in pediatric anesthesia and serve as primary or back-up devices for difficult airway management. Most SGA are marketed without proper clinical evaluation. The purpose of this study was to evaluate the performance of the pediatric LMA Supreme™, Air-Q® and Ambu® Aura-i™. Read More

    Multicenter assessment of sedation and delirium practices in the intensive care units in Poland - is this common practice in Eastern Europe?
    BMC Anesthesiol 2017 Sep 2;17(1):120. Epub 2017 Sep 2.
    Department of Medicine/Allergy, Pulmonary and Critical Care, Vanderbilt University School ofMedicine, Vetaran's Affairs Geriatric Research Education Clinical Center (GRECC) for Tennessee Valley, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, USA.
    Background: The majority of critically ill patients experience distress during their stay in the Intensive Care Unit (ICU), resulting from systemic illness, multiple interventions and environmental factors. Providing humane care should address concomitant treatment of pain, agitation and delirium. The use of sedation and approaches to ICU delirium should be monitored according to structured guidelines. Read More

    The role of increased body mass index in outcomes of sepsis: a systematic review and meta-analysis.
    BMC Anesthesiol 2017 Aug 31;17(1):118. Epub 2017 Aug 31.
    Department of Anesthesiology and Intensive Care Medicine, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310003, China.
    Background: The role of increased body mass index (BMI) in sepsis is controversial. We aimed to evaluate the associations between overweight (25 kg/m(2) < BMI ≤ 29.9 kg/m(2)), obese (30 kg/m(2) < BMI ≤ 39. Read More

    Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia.
    BMC Anesthesiol 2017 Aug 30;17(1):117. Epub 2017 Aug 30.
    Department of Anesthesiology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Jinan, Shandong, 250012, China.
    Background: The present study aims to investigate the protective effects of dexmedetomidine (DMED) on hypoxia ischemia injury induced by oxygen and glucose deprivation (OGD) in PC12 and primary neuronal cells.

    Methods: PC12 cells exposed to OGD was used to establish ischemia model. The OGD-induced cell injury was evaluated by alterations of cell viability, apoptosis and expressions of apoptosis-associated proteins. Read More

    Assessing advances in regional anesthesia by their portrayals in meta-analyses: an alternative view on recent progress.
    BMC Anesthesiol 2017 Aug 29;17(1):112. Epub 2017 Aug 29.
    Department of Anesthesiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA, 20115, USA.
    Background: The aim of this study was to delineate research reflecting advances in regional/local anesthesia where recent clinical progress was clearly defined by meta-analysis.

    Methods: We conducted a search to identify all articles with meta-analyses of randomized clinical trials related to the field of regional/local anesthesia. From 279 titles, after multiple exclusions, 16 meta-analyses on important clinical practice developments with high potential for a positive conclusion on the effectiveness of the treatment were left for the assessment. Read More

    Combined spinal-epidural anesthesia for cesarean delivery in a patient with cor triloculare biventriculare.
    BMC Anesthesiol 2017 Aug 29;17(1):115. Epub 2017 Aug 29.
    Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, NO. 99 Huaihai Road, Quanshan District, Xuzhou city, Jiangsu Province, China.
    Background: Cor triloculare biventriculare accounts for approximately 0.31% of cases of congenital heart disease (CHD). Moreover, people with cor triloculare biventriculare always have shorter life spans, and cases of gestation are rare. Read More

    Influence of the postoperative inflammatory response on cognitive decline in elderly patients undergoing on-pump cardiac surgery: a controlled, prospective observational study.
    BMC Anesthesiol 2017 Aug 29;17(1):113. Epub 2017 Aug 29.
    Department of Anaesthesia and Intensive Therapy, Semmelweis University, P.O.B. 2, Budapest, H-1428, Hungary.
    Background: The role of non-infective inflammatory response (IR) in the aetiology of postoperative cognitive dysfunction (POCD) is still controversial. The aim of this controlled, prospective observational study was to assess the possible relationship between the grade of IR, defined by procalcitonin (PCT) changes, and development of POCD related to cardiac surgery.

    Methods: Forty-two patients, who were ≥ 60 years of age and scheduled for elective cardiac surgery, were separated into the low inflammatory (LIR) and high inflammatory (HIR) response groups based on their PCT levels measured on the first postoperative day. Read More

    Anesthetic management of a pediatric patient with Electron Transfer Flavoprotein Dehydrogenase deficiency (ETFDH) and acute appendicitis: case report and review of the literature.
    BMC Anesthesiol 2017 Aug 29;17(1):116. Epub 2017 Aug 29.
    Department of Pediatric Surgery, University Hospital of Crete, 71110, Herakllion, Greece.
    Background: Mitochondria are the energy producing organelles practically in every human cell except erythrocytes. Indeed mitochondria are widespread in high energy requiring organs like brain, heart and muscles. Currently there are no clinical trials supporting with clear evidence which is the most suitable surgical or anesthetic management of a patient with known mitochondrial disease presenting with surgical disorders. Read More

    Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy.
    BMC Anesthesiol 2017 Aug 29;17(1):114. Epub 2017 Aug 29.
    Department of Anesthesiology, University Hospital of Erlangen, Krankenhausstrasse 12, 91054, Erlangen, Germany.
    Background: Seizure duration in electroconvulsive therapy (ECT) is positively related with patients' outcome. This study sought to investigate the impact of anesthetic management on seizure duration, and the impact of selected drugs (theophylline, remifentanil, S-ketamine) on seizure duration.

    Methods: Retrospective analysis of all patients undergoing ECT at our institution from January 2011 to April 2012 was performed based on electronic medical chart and review of existing quality improvement data. Read More

    Ketamine attenuates the glutamatergic neurotransmission in the ventral posteromedial nucleus slices of rats.
    BMC Anesthesiol 2017 Aug 23;17(1):111. Epub 2017 Aug 23.
    Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Dalian Road, Zunyi, Guizhou, 201, China.
    Background: Ketamine is a frequently used intravenous anesthetic, which can reversibly induce loss of consciousness (LOC). Previous studies have demonstrated that thalamocortical system is critical for information transmission and integration in the brain. The ventral posteromedial nucleus (VPM) is a critical component of thalamocortical system. Read More

    Adequate interval for the monitoring of vital signs during endotracheal intubation.
    BMC Anesthesiol 2017 Aug 22;17(1):110. Epub 2017 Aug 22.
    Department of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
    Background: In the perioperative period, it may be inappropriate to monitor vital signs during endotracheal intubation using the same interval as during a hemodynamically stable period. The aim of the present study was to determine whether it is appropriate to use the same intervals used during the endotracheal intubation and stable periods to monitor vital signs of patients under general anesthesia.

    Methods: The mean arterial pressure (MAP) and heart rate (HR) were continuously measured during endotracheal intubation (15 min after intubation) and hemodynamically stable (15 min before skin incision) periods in 24 general anesthesia patients. Read More

    Minimal shedding of the glycocalyx layer during abdominal hysterectomy.
    BMC Anesthesiol 2017 Aug 22;17(1):107. Epub 2017 Aug 22.
    Department of Anaesthesiology and Intensive Care, Riga Stradins University and Paul Stradins Clinical University Hospital, Riga, Latvia.
    Background: Surgery with and without hypervolaemia may cause shedding (breakdown) of the endothelial glycocalyx layer, but the severity of this problem is unclear.

    Methods: In this preliminary report of a larger clinical trial, the plasma and urine concentrations of three biomarkers of glycocalyx shedding (syndecan-1, hyaluronic acid and heparan sulfate) were measured in seven patients before, during, and after open hysterectomy. The fluid therapy consisted of 25 ml/kg (approximately 2 l) of Ringer's lactate, which was infused over 30 min when the surgery started. Read More

    Recovery and prediction of postoperative muscle power - is it still a problem?
    BMC Anesthesiol 2017 Aug 22;17(1):108. Epub 2017 Aug 22.
    Department of Anaesthesia and Intensive Care Medicine, University of Marburg, Baldinger Strasse, D-35033, Marburg, Germany.
    Background: In the postoperative period, immediate recovery of muscular power is essential for patient safety, but this can be affected by anaesthetic drugs, opioids and neuromuscular blocking agents (NMBA). In this cohort study, we evaluated anaesthetic and patient-related factors contributing to reduced postoperative muscle power and pulse oximetric saturation.

    Methods: We prospectively observed 615 patients scheduled for minor surgery. Read More

    Impact of intrathecal morphine analgesia on the incidence of pulmonary complications after cardiac surgery: a single center propensity-matched cohort study.
    BMC Anesthesiol 2017 Aug 22;17(1):109. Epub 2017 Aug 22.
    Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, Rue Gabrielle-Perret-Gentil 4, -1211, Geneva, CH, Switzerland.
    Background: Acute pain and systemic opioids may both negatively impact respiratory function after cardiac surgery. This study analyzes the local practice of using intrathecal morphine analgesia (ITMA) with minimal parenteral opioid administration in cardiac surgery, specifically the impact on postoperative pulmonary complications (PPCs).

    Methods: Data from adult patients who underwent elective cardiac surgery between January 2002, and December 2013 in a single center were analyzed. Read More

    Comparison of the trapezius and the adductor pollicis muscle as predictor of good intubating conditions: a randomized controlled trial.
    BMC Anesthesiol 2017 Aug 17;17(1):106. Epub 2017 Aug 17.
    Department of Anesthesia and Intensive Care Medicine, University of Rostock, Rostock, Germany.
    Background: Adequate muscle relaxation is important for ensuring optimal conditions for intubation. Although acceleromyography of the adductor pollicis muscle is commonly used to assess conditions for intubation, we hypothesized that acceleromyography of the trapezius is more indicative of optimal intubating conditions. The primary outcome was the difference between both measurement sites with regard to prediction of good or acceptable intubating conditions. Read More

    Systemic LPS resulted in a transient hippocampus malfunction but a prolonged corpus callosum injury.
    BMC Anesthesiol 2017 Aug 14;17(1):105. Epub 2017 Aug 14.
    Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.
    Background: To investigate the effect of systemic lipopolysaccharide (LPS) on function of hippocampus and corpus callosum (CC) in adult rats.

    Methods: Adult rats with mature white matter tract were divided into systemic LPS and saline injection groups. Animal were euthanized following 3 daily injections (day 3) and 3-day after cessation of injections (day 6). Read More

    Incidence and risk factors of chronic pain following hysterectomy among Southern Jiangsu Chinese Women.
    BMC Anesthesiol 2017 Aug 11;17(1):103. Epub 2017 Aug 11.
    The Affiliated Yixing Hospital of Jiangsu University, 75 Tongzhenguan Road, Yixing, Jiangsu, 214200, People's Republic of China.
    Background: Chronic post-surgical pain (CPSP) after hysterectomy has been recognized as a major clinical problem in the Western World. Reports on post-hysterectomy pain are relatively scarce in China. The aim of the current study was to prospectively investigate the incidence and the potential risk factors of CPSP at 3 months following hysterectomy in Chinese population. Read More

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