11,190 results match your criteria BJU international[Journal]


Post-operative complications increase the risk of long-term chronic kidney disease after nephron sparing surgery in renal cancer patients with normal preoperative renal function.

BJU Int 2019 Feb 15. Epub 2019 Feb 15.

Università Vita-Salute San Raffaele, Milan, Italy.

Objectives: To investigate whether post-operative complications may affect long-term functional outcomes of renal patients treated with nephron sparing surgery (NSS).

Materials And Methods: We performed an observational study enrolling 596 patients with pre-operative normal renal function treated with NSS for clinical T1abN0M0 renal mass. Cox regression models estimated hazard ratios (HR) and 95% confidence intervals (CI) for CKD including as covariates age, comorbidity (scored as for the Charlson comorbidity index), hypertension, tumor size, pre-operative eGFR, eGFR<60 ml/min/1. Read More

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http://dx.doi.org/10.1111/bju.14712DOI Listing
February 2019

Taxane-based chemohormonal therapy for metastatic hormone-sensitive prostate cancer: A Cochrane Review.

BJU Int 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University of Minnesota, Minneapolis, USA.

Objectives: Androgen deprivation therapy (ADT) has historically been the main management option for men with metastatic, hormone-sensitive prostate cancer. Over the last two decades, a number of agents have demonstrated a benefit in castration-resistant disease[1] and there has been interest to employ these drugs earlier in the disease course when the cancer is hormone-sensitive. Taxane-based chemotherapy has been utilized in such a manner and we aimed to assess the effects of early taxane-based chemohormonal therapy for newly diagnosed, metastatic, hormone-sensitive prostate cancer. Read More

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http://dx.doi.org/10.1111/bju.14711DOI Listing
February 2019

Palliative Care Use Among Patients with Bladder Cancer.

BJU Int 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Objectives: To describe the rate and determinants of palliative care use among Medicare beneficiaries with bladder cancer and encourage a national dialogue on improving coordinated urologic, oncologic, and palliative care in patients with genitourinary malignancies.

Materials And Methods: Using Surveillance, Epidemiology, and End Results-Medicare data, we identified patients diagnosed with muscle-invasive bladder cancer between 2008-2013. Our primary outcome was receipt of palliative care, defined as the presence of a claim submitted by a Hospice and Palliative Medicine subspecialist. Read More

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http://dx.doi.org/10.1111/bju.14708DOI Listing
February 2019

Medium term oncological outcomes in a large cohort of men treated with either focal or hemi-ablation using HIFU for primary localized prostate cancer.

BJU Int 2019 Feb 12. Epub 2019 Feb 12.

Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK.

Objective: To report medium-term oncological outcomes in patients receiving primary focal treatment with HIFU for PCa.

Patients And Methods: Consecutive men treated by means of primary focal HIFU for PCa at two centres by 6 treating clinicians were assessed. Patients were submitted to either a focal ablation or hemiablation using HIFU (Sonablate 500). Read More

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http://dx.doi.org/10.1111/bju.14710DOI Listing
February 2019

The Landscape of Urologic Retractions: The Prevalence of Reported Research Misconduct.

BJU Int 2019 Feb 12. Epub 2019 Feb 12.

Department of Urology, University of California-San Francisco, San Francisco, California.

Objective: To evaluate the landscape of retractions of literature and determine the prevalence of research misconduct in the field of Urology.

Methods: Three databases (PUBMED, EMBASE, Retraction Watch) were queried for all retracted studies of urologic topics in both urologic and non-urologic journals from April 1999 to March 2018. Two reviewers screened the records and determined the final list of articles to be included in the analysis. Read More

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http://dx.doi.org/10.1111/bju.14706DOI Listing
February 2019

Best practice in Active Surveillance for men with prostate cancer: A Prostate Cancer UK consensus statement.

BJU Int 2019 Feb 11. Epub 2019 Feb 11.

Division of Surgery& Interventional Science, University College London, London, UK.

Objectives: To develop a consensus statement on current best practice of active surveillance (AS) in the UK, informed by patients and clinical experts.

Subjects And Methods: A consensus statement was drafted on the basis of three sources of data: systematic literature search of national and international guidelines; data arising from a Freedom of Information (FOI) Act request to UK urology departments regarding their current practice of AS; survey and interview responses from men with localised prostate cancer regarding their experiences and views of AS. The Prostate Cancer UK Expert Reference Group (ERG) on Active Surveillance was then convened to discuss and refine the statement. Read More

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http://dx.doi.org/10.1111/bju.14707DOI Listing
February 2019

Use of Multi-Parametric Magnetic Resonance Imaging in Prostate Cancer Active Surveillance.

BJU Int 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology and University of California Davis Comprehensive Cancer Center, Sacramento, CA, USA.

Objectives: To review the role of multi-parametric magnetic resonance imaging (mpMRI) for active surveillance of prostate cancer.

Materials And Methods: We performed a comprehensive search of Medline and Embase databases for relevant articles. Search terms included prostate cancer, active surveillance or monitoring, expectant management, and MRI in the English language. Read More

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http://dx.doi.org/10.1111/bju.14705DOI Listing
February 2019

The impact of non-urothelial variant histology on oncological outcomes following radical cystectomy.

BJU Int 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Objectives: To determine if the presence of non-urothelial variant histology (NUVH) is associated with a poorer prognosis following radical cystectomy compared to pure urothelial carcinoma.

Patients And Methods: A prospectively maintained database of all patients undergoing radical cystectomy (RC) at a high-volume regional tertiary bladder cancer service between January 2010 and January 2017 was retrospectively analysed looking for patients displaying NUVH. Multivariate Cox proportional hazards regression analysis was used to determine disease recurrence, overall and bladder cancer specific survival as well as lymph node positivity. Read More

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http://dx.doi.org/10.1111/bju.14704DOI Listing
February 2019

Aquablation for BPH in Large Prostates (80-150cc): 6-Month Results From the WATER II Trial.

BJU Int 2019 Feb 8. Epub 2019 Feb 8.

University of Montreal Hospital Center, Université de Montréal, Montreal, Quebec, CAN.

Background And Aims: The outcomes of Aquablation in men with lower urinary tract symptoms due to benign prostatic hyperplasia (BPH) with prostate volumes between 80-150cc have not been prospectively studied. Present 6-month safety and effectiveness data from a multicenter prospective study of Aquablation.

Methods: Between September and December 2017, 101 men with BPH due to LUTS were prospectively enrolled at 16 centers from Canada and the US. Read More

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http://dx.doi.org/10.1111/bju.14703DOI Listing
February 2019

Prostate cancer screening: where are we now?

BJU Int 2019 Feb 5. Epub 2019 Feb 5.

The Urology Centre, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT.

Screening aims to identify prostate cancer at an early stage where curative treatment can reduce mortality. Given high false positive and false negative rates, however, the use of prostate-specific antigen (PSA) in screening has long been controversial. Recent systematic reviews comprising large randomised-controlled trials (RCTs) with long-term follow-up have demonstrated just modest benefit regarding mortality reduction compared to standard care [1,2]. Read More

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http://dx.doi.org/10.1111/bju.14692DOI Listing
February 2019

How accurate is multi-parametric MRI for predicting prostate cancer pathology and tumour staging in the real world? - An Australian multi-centre study.

BJU Int 2019 Feb 3. Epub 2019 Feb 3.

Gosford Hospital and Gosford Private Hospital, Gosford, Australia.

Objectives: To assess the accuracy of multi-parametric MRI (mpMRI) for the detection of significant prostate cancer in men undergoing radical prostatectomy (RP) in an Australian multi-centre setting. Secondary aims were to assess concordance between mpMRI and RP for local tumour staging and index lesion locations.

Patients And Methods: Patients who had an mpMRI performed within 12 months of RP between January 2013 and August 2016 at 3 Australian Sites were included (Central Coast, NSW, St Vincents Hospital, Melbourne, VIC, and Bendigo Hospital, VIC). Read More

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http://dx.doi.org/10.1111/bju.14696DOI Listing
February 2019

Identification of novel oncogenic events occurring early in prostate carcinogenesis using purified autologous malignant and non-malignant prostate epithelial cells.

BJU Int 2019 Feb 3. Epub 2019 Feb 3.

Eastern Health Clinical School, Faculty of Medicine, Nursing& Health Sciences, Monash University, Melbourne, Australia.

Objective: To interrogate enriched prostate cancer cells and autologous non-malignant prostate epithelial cells from men with localized prostate cancer, in order to identify early oncogenic pathways.

Background: Previous work characterizing early oncogenic changes in prostate cancer, including that of the Cancer Genome Atlas, has used tissue containing cells from non-malignant components as well as from non-epithelial tissue compartments, diluting cancer-related changes.

Patients And Methods: We collected malignant and matched nonmalignant prostatectomy samples from men with adenocarcinoma involving two or more contiguous areas in only one lobe of the prostate. Read More

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http://dx.doi.org/10.1111/bju.14695DOI Listing
February 2019

Segmental resection of distal ureter with termino-terminal ureteral anastomosis vs bladder cuff removal and ureteral re-implantation for upper tract urothelial carcinoma: results of a multicentre study.

BJU Int 2019 Feb 3. Epub 2019 Feb 3.

Department of Surgical, Oncological and Oral Sciences, Section of Urology, University of Palermo, Palermo, Italy.

Objectives: To compare overall (OS), cancer-specific (CSS), recurrence free survival (RFS) and post-operative renal function among patients affected by upper tract urothelial carcinoma (UTUC) of the distal (lower lumbar and pelvic) ureter, electively treated with segmental resection and termino-terminal anastomosis (TT) vs bladder cuff removal and ureteral re-implantation (RR).

Patients And Methods: A multicentre retrospective study, including 84 patients diagnosed with UTUC of the distal ureter and treated with TT or RR, is presented. The primary endpoint was to compare TT and RR in terms of OS, CSS and RFS. Read More

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http://dx.doi.org/10.1111/bju.14697DOI Listing
February 2019

Mix methods approach to explore patients' perspectives on the acceptability of a urinary biomarker test in replacement of cystoscopy in bladder cancer surveillance.

BJU Int 2019 Jan 29. Epub 2019 Jan 29.

Division of Surgery and Interventional Science, University College London, London, UK.

Objective: To determine the minimal accepted sensitivity (MAS) of a urine biomarker that patients are willing to accept to replace cystoscopy and to qualitatively assess their views and reasons.

Patient And Methods: Patients were part of a prospective multi-center observational study recruiting patients with bladder cancer for a urine biomarker study (DETECT II; ClinicalTrials.gov: NCT02781428). Read More

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http://dx.doi.org/10.1111/bju.14690DOI Listing
January 2019

Cancer Core Length from Targeted Biopsy: An Index of Prostate Cancer Volume and Pathologic Stage.

BJU Int 2019 Jan 29. Epub 2019 Jan 29.

Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, 300 Stein Plaza, 3rd Floor, Los Angeles, CA, 90095.

Objective: To study the relationship of maximum cancer core length, on targeted biopsy of MRI-visible index lesions, to volume of that tumor found at prostatectomy.

Patients And Methods: 205 men undergoing fusion biopsy and radical prostatectomy were divided into two groups: 136 in whom the maximum cancer core length came from an index MRI-visible lesion (targeted) and 69 in whom maximum cancer core length came from a non-targeted lesion. MRI was 3T multi-parametric and biopsy was via MRI-US fusion. Read More

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http://dx.doi.org/10.1111/bju.14691DOI Listing
January 2019

Peri-operative and oncological outcomes of radical prostatectomy for high-risk prostate cancer in the UK: an analysis of surgeon reported data.

BJU Int 2019 Jan 25. Epub 2019 Jan 25.

University College London Hospital NHS Foundation Trust, London, UK.

Objectives: To analyse the peri-operative and oncological outcomes of all RPs performed for high risk prostate cancer(PCa) in the British Association of Urological Surgeons (BAUS) national registry from 2014-2015.

Patients And Methods: We identified and analysed outcomes of all RPs performed for high-risk PCa(clinical stage>T2 and/or biopsy Gleason Grade>7 and/or pre-operative PSA≥20) in the national registry for 2014 and 2015. Surgeon reporting of data was mandated during this period. Read More

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http://dx.doi.org/10.1111/bju.14687DOI Listing
January 2019

Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia.

BJU Int 2019 Jan 25. Epub 2019 Jan 25.

Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Lower urinary tract symptoms (LUTS) in a male patient may be due to benign prostatic hyperplasia (BPH-LUTS). In a routine clinical practice, BPH -LUTS is medically managed by Alpha-blockers (ABs) and add-on 5-alpha reductase inhibitors (5-ARIs). Epidemiological studies have shown an association of BPH-LUTS with erectile dysfunction (ED)[1]. Read More

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http://dx.doi.org/10.1111/bju.14689DOI Listing
January 2019
1 Read

Readressing the rationale of irradiation in Stage I seminoma guidelines: A critical essay.

BJU Int 2019 Jan 25. Epub 2019 Jan 25.

Department of Radiation Oncology, Leuven University Hospital, Leuven, Belgium.

Germ cell tumors (GCT), accounting for 95% of malignant testicular tumors, can be divided into two groups: seminoma (SGCT) and non-seminoma (NSGCT). Seminomas typically arise in men in the fourth decade of life, compromising 60% of the GCT. At diagnosis, approximately 75% present with local disease (Stage I); 15% is detected with metastatic regional lymph nodes (Stage II) and 5-10% present with juxtaregional or visceral metastasis (Stage III) . Read More

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http://dx.doi.org/10.1111/bju.14686DOI Listing
January 2019
2 Reads

The Collaborative Management of Late Radiation Urological Complications.

BJU Int 2019 Jan 23. Epub 2019 Jan 23.

Olivia Newton John Cancer Centre, Melbourne, Australia.

The importance of a multi-disciplinary collaborative approach to urological radiation complications is highlighted in a recent study by Ma et al [1]. Their single-centre retrospective study adds to the existing body of knowledge, and the controversy in the field, regarding radiotherapy complications and toxicities from the urological perspective. The work provided some meaningful information about a subsection of patients presenting to one of the largest urology units in Australia. Read More

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http://dx.doi.org/10.1111/bju.14679DOI Listing
January 2019

Chemotherapy regimen is associated with venous thromboembolism risk in urothelial tract cancer patients.

BJU Int 2019 Jan 22. Epub 2019 Jan 22.

University of Washington, Seattle, Washington.

Background: Cisplatin chemotherapy is associated with increased venous thromboembolism (VTE) risk; however, other agents have been hypothesized to increase risk.

Objective: To assess the association of VTE with different chemotherapy regimens in urothelial tract cancer patients.

Design, Setting, And Participants: We identified patients ≥66 year-old diagnosed with urothelial tract cancer from 1998 to 2011 in the Surveillance, Epidemiology, and End Results (SEER) Medicare-linked database. Read More

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http://dx.doi.org/10.1111/bju.14685DOI Listing
January 2019
1 Read

Old instillations and new implications for bladder cancer: the urinary microbiome and intravesical BCG.

BJU Int 2019 Jan 21. Epub 2019 Jan 21.

Department of Urology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.

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http://dx.doi.org/10.1111/bju.14683DOI Listing
January 2019
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External validation of a novel side-specific, multiparametric magnetic resonance imaging-based nomogram for the prediction of extracapsular extension of prostate cancer: preliminary outcomes on a series diagnosed with mpMRI targeted plus systematic saturation biopsy.

BJU Int 2019 Jan 18. Epub 2019 Jan 18.

Department of Urology, University of Modena and Reggio Emilia, Italy.

we read with great interest the article from Martini and Coworkers, who developed a novel side-specific, multiparametric magnetic resonance imaging (mpMRI)-based nomogram for the prediction of extracapsular extension (ECE) of prostate cancer (PCa). The knowledge of the presence of ECE would help surgeons tailor the amount of nerve-sparing and improve the tradeoff between functional and oncological outcomes of radical prostatectomy (RP)[1,2]. Several nomograms aimed to predict ECE have been developed, based on clinical and pathological variables from prostate biopsy. Read More

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http://dx.doi.org/10.1111/bju.14665DOI Listing
January 2019
2 Reads

Daily exercise is daily medicine.

BJU Int 2019 Feb;123(2):200-201

The London Clinic, London, UK.

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http://dx.doi.org/10.1111/bju.14625DOI Listing
February 2019
1 Read

Multiparametric magnetic resonance imaging for prostate cancer detection: do clinical trial findings reflect real-world practice?

BJU Int 2019 Feb;123(2):197-198

Division of Urological Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bju.14614DOI Listing
February 2019
1 Read

Does knowing the risk of relapse in localized renal cell carcinoma matter?

Authors:
Matthew Wszolek

BJU Int 2019 Feb;123(2):201-202

Urology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/bju.14626DOI Listing
February 2019
2 Reads

Postoperative radiation and hormonal therapy for men with node-positive prostate cancer: a new standard?

Authors:
Brent S Rose

BJU Int 2019 Feb;123(2):199-200

Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA, USA.

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http://doi.wiley.com/10.1111/bju.14501
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http://dx.doi.org/10.1111/bju.14501DOI Listing
February 2019
4 Reads

Cytoreductive nephrectomy is dead, long live cytoreductive nephrectomy.

BJU Int 2019 Jan 17. Epub 2019 Jan 17.

Department of Urology, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1111/bju.14675DOI Listing
January 2019
2 Reads

Diagnostic accuracy, clinical utility and influence on decision-making of a methylation urine biomarker test in the surveillance of non-muscle-invasive bladder cancer.

BJU Int 2019 Jan 17. Epub 2019 Jan 17.

Department of Urology, Medical University of Vienna, Vienna, Austria.

Objectives: To investigate prospectively the clinical utility and influence on decision-making of Bladder EpiCheck™, a non-invasive urine test, in the surveillance of non-muscle-invasive bladder cancer (NMIBC).

Materials And Methods: Urine samples from 440 patients undergoing surveillance for NMIBC were prospectively collected at five centres and evaluated using the Bladder EpiCheck test (NCT02647112). A multivariable nomogram and decision-curve analysis (DCA) were used to evaluate the impact of Bladder EpiCheck on decision-making when used in routine clinical practice. Read More

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http://dx.doi.org/10.1111/bju.14673DOI Listing
January 2019
1 Read

Conservative treatment for leg oedema and the effect on nocturnal polyuria in patients with spinal cord injury.

BJU Int 2019 Jan 17. Epub 2019 Jan 17.

Department of Urology, Ghent University Hospital, Ghent University, Gent, Belgium.

Objectives: To evaluate the possible influence of non-pharmacological interventions, such as compressive bandages and intermittent pneumatic compression (IPC), on leg oedema and nocturnal polyuria (NP), and the possible interrelation between both pathologies in patients with spinal cord injury (SCI), as patients with SCI often have leg oedema and during the night the oedema decreases as a result of natural drainage mechanisms that can cause NP.

Patients And Methods: Patients with SCI who followed their first rehabilitation after their SCI with bilateral leg oedema and/or with as much or a larger urine volume at night as during the day. The patients were all wheelchair users and followed the rehabilitation programme daily for 3 weeks. Read More

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http://dx.doi.org/10.1111/bju.14672DOI Listing
January 2019
1 Read

Feasibility of robot-assisted prostatectomy performed at ultra-low pneumoperitoneum pressure of 6 mmHg and comparison of clinical outcomes vs standard pressure of 15 mmHg.

BJU Int 2019 Jan 17. Epub 2019 Jan 17.

OhioHealth Robotic Urologic Surgery, Dublin, OH, USA.

Objectives: To evaluate the feasibility of performing robot-assisted laparoscopic prostatectomy (RALP) at an ultra-low pressure of 6 mmHg and to assess the potential impact on its clinical outcomes, as compared to those of a historical cohort of patients in which RALP was performed at a pressure of 15 mmHg.

Patients And Methods: We evaluated 600 consecutive RALP procedures, performed by a single surgeon, including 300 procedures performed at 6 mmHg and the previous 300 performed at 15 mmHg. We compared preoperative patient characteristics and outcomes including pain scores, morphine equivalents, length of stay (LOS) and complications. Read More

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http://dx.doi.org/10.1111/bju.14682DOI Listing
January 2019
2 Reads

Does time from diagnosis to treatment of high- or very-high-risk prostate cancer affect outcome?

BJU Int 2019 Jan 17. Epub 2019 Jan 17.

University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

Objective: To determine whether time from diagnosis to treatment impacted outcomes in a multicentre cohort of high- and very-high-risk (VHR) patients with prostate cancer undergoing radical prostatectomy (RP).

Patients And Methods: In all, 1392 patients from three tertiary centres who underwent RP for either high-risk or VHR disease, from 2005 to 2015, were identified. The cohort was divided into tertiles based on time from diagnostic biopsy to RP. Read More

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http://dx.doi.org/10.1111/bju.14671DOI Listing
January 2019
1 Read

Consensus statements on the management of clinically localized prostate cancer from the Hong Kong Urological Association and the Hong Kong Society of Uro-Oncology.

BJU Int 2019 Jan 17. Epub 2019 Jan 17.

Department of Clinical Oncology, Queen Mary Hospital, University of Hong Kong, Hong Kong.

Objective: To formulate consensus statements to facilitate physician management strategies for patients with clinically localized prostate cancer (PCa) in Hong Kong by jointly convening a panel of 12 experts from the two local professional organizations representing PCa specialists, who had previously established consensus statements on the management of metastatic PCa for the locality.

Methods: Through a series of meetings, the panellists discussed their clinical experience and the published evidence regarding various areas of the management of localized PCa, then drafted consensus statements. At the final meeting, each drafted statement was voted on by every panellist based on its practicability of recommendation in the locality. Read More

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http://dx.doi.org/10.1111/bju.14681DOI Listing
January 2019
2 Reads
3.533 Impact Factor

The use of the IDEAL framework in the urologic literature: Where are we in 2018?

BJU Int 2019 Jan 17. Epub 2019 Jan 17.

University of Minnesota, Department of Urology, Minneapolis, Minnesota, USA.

Objectives: To assess uptake and application of the IDEAL principles in original surgical procedure or device-related clinical research studies as well as its reported relevance as characterized by secondary publications, editorials and reviews.

Materials And Methods: IDEAL (Idea, Development, Exploration, Assessment, Long-term study) is a framework that provides stage-specific guidance for surgical innovation and represented a major advance towards raising evidentiary standards. We performed a comprehensive literature search of all urology-related publications citing one or more of seven key publications on IDEAL in The Lancet and BMJ using multiple databases up to 31 December 2017. Read More

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http://dx.doi.org/10.1111/bju.14676DOI Listing
January 2019
1 Read

Nomogram for predicting the likelihood of postoperative surgical complications in patients treated with partial nephrectomy: a prospective multicentre observational study (the RECORd 2 project).

BJU Int 2019 Jan 17. Epub 2019 Jan 17.

Unit of Oncologic Minimally-Invasive Urology and Andrology, Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.

Objective: To identify meaningful predictors and to develop a nomogram of postoperative surgical complications in patients treated with partial nephrectomy (PN).

Patients And Methods: We prospectively evaluated 4308 consecutive patients who had surgical treatment for renal tumours, between 2013 and 2016, at 26 Italian urological centres (RECORd 2 project). A multivariable logistic regression for surgical complications was performed. Read More

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http://dx.doi.org/10.1111/bju.14680DOI Listing
January 2019
2 Reads

Androgen deprivation therapy for prostate cancer and risk of dementia.

BJU Int 2019 Jan 13. Epub 2019 Jan 13.

Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Objectives: To study whether androgen deprivation therapy (ADT), the mainstay treatment for advanced and disseminated prostate cancer, is associated with risk of dementia.

Methods: Risk of dementia in men with prostate cancer primarily managed with ADT or watchful waiting (WW) in the Prostate Cancer Database Sweden, PCBaSe, was compared with that in prostate cancer-free men, matched on birth year and county of residency. We used Cox regression to calculate the hazard ratios (HRs) for Alzheimer's and non-Alzheimer's dementia (vascular dementia, dementia secondary to other diseases or unspecified dementias) for different types and duration of ADT and oral antiandrogens (AAs) as well as for men managed with WW. Read More

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http://dx.doi.org/10.1111/bju.14666DOI Listing
January 2019
7 Reads

Sildenafil, a Phosphodiesterase Type 5 Inhibitor, augments sphincter bursting and bladder afferent activity to enhance storage function and voiding efficiency in mice.

BJU Int 2019 Jan 12. Epub 2019 Jan 12.

School of Physiology, Pharmacology and Neuroscience, Faculty of Biomedical Sciences, University of Bristol, Bristol, BS8 1TD.

Objectives: To investigate the influence of low dose phosphodiesterase type 5 inhibitors (PDE5-I) on the function of the mouse lower urinary tract (LUT).

Materials And Methods: Adult male mice were decerebrated and arterially-perfused with a carbogenated Ringer's solution to establish the decerebrate arterially-perfused mouse (DAPM). To allow distinction between central neural and peripheral actions of sildenafil, experiments were conducted in both the DAPM and in a 'pithed' DAPM which has no functional brainstem or spinal cord. Read More

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http://dx.doi.org/10.1111/bju.14664DOI Listing
January 2019
1 Read

Cigarette smoking is associated with adverse pathological response and increased disease recurrence amongst patients with muscle-invasive bladder cancer treated with cisplatin-based neoadjuvant chemotherapy and radical cystectomy: a single-centre experience.

BJU Int 2019 Jan 8. Epub 2019 Jan 8.

Department of Urology, Mayo Clinic, Rochester, MN, USA.

Objective: To investigate the association between smoking status and pathological response to cisplatin-based neoadjuvant chemotherapy (NAC) and survival outcomes in patients with muscle-invasive bladder cancer (MIBC) treated with radical cystectomy (RC).

Patients And Methods: We reviewed 201 patients treated with NAC and RC for cT2-cT4N0M0 BC between 01/1999 and 01/2015. Smoking status was categorised as: 'never', 'former', and 'current' smoker. Read More

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http://doi.wiley.com/10.1111/bju.14612
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http://dx.doi.org/10.1111/bju.14612DOI Listing
January 2019
5 Reads

Corrigendum.

Authors:

BJU Int 2018 Dec 6;122(6):E4. Epub 2018 Nov 6.

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http://dx.doi.org/10.1111/bju.14598DOI Listing
December 2018
1 Read

Effectiveness of a web-based treatment decision aid for men with lower urinary tract symptoms due to benign prostatic hyperplasia.

BJU Int 2018 Dec 27. Epub 2018 Dec 27.

Department of Urology, Elisabeth-Tweesteden Hospital, Hilvarenbeekseweg 60, 5022 GC, Tilburg, The Netherlands.

Objectives: To evaluate the effectiveness of a web-based decision aid (DA) with values clarification exercises (VCEs) compared with usual care for men with lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH).

Subjects/patients And Methods: Between July 2016 and January 2017 all new LUTS/BPH patients who consulted the urologist were invited to use the DA and participate in this prospective questionnaire study. Patients who consulted the urologist between December 2015 and February 2016 served as controls. Read More

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http://dx.doi.org/10.1111/bju.14646DOI Listing
December 2018
1 Read

Effect of preoperative detrusor underactivity on long-term surgical outcomes of photovaporization and holmium laser enucleation in men with benign prostatic hyperplasia: a lesson from 5-year serial follow-up data.

BJU Int 2018 Dec 24. Epub 2018 Dec 24.

Department of Urology, Seoul National University College of Medicine, Seoul, Korea.

Objectives: To investigate the impact of preoperative detrusor underactivity (DU) on serial treatment outcomes over the course of 5 years after photovaporization (PV) or holmium laser enucleation (HoLEP) in patients with benign prostatic hyperplasia (BPH), to compare its impact after PV vs HoLEP, and to identify predictors of long-term lower urinary tract symptoms (LUTS) improvement.

Materials And Methods: This study involved 245 patients with BPH who had complete 5-year follow-up data (PV using 120W-HPS, n = 143, HoLEP, n = 102), grouped as follows: PV-HPS-DU(+), n = 114; PV-HPS-DU(-), n = 29; HoLEP-DU(+), n = 56; and HoLEP-DU(-), n = 46. Bladder contractility index (BCI) < 100 was regarded as DU. Read More

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http://doi.wiley.com/10.1111/bju.14661
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http://dx.doi.org/10.1111/bju.14661DOI Listing
December 2018
9 Reads

Safety and effectiveness of zero antimicrobial prophylaxis protocol for outpatient cystourethroscopy.

BJU Int 2018 Dec 22. Epub 2018 Dec 22.

Department of Urology, Oregon Health and Science University, Portland, OR, USA.

Objectives: To examine compliance and clinical outcomes after implementation of a zero antimicrobial prophylaxis protocol for outpatient cystoscopy in an academic centre.

Patients And Methods: Medical records of all patients who underwent diagnostic cystoscopy in the year preceding and year following protocol implementation were evaluated for urinary tract infection (UTI) diagnosis within 30 days of cystoscopy. Variables compared between groups included age, sex, smoking history, benign prostatic hyperplasia (BPH) diagnosis, diabetes mellitus, immunosuppression, catheter use (indwelling, suprapubic, or intermittent), and previous lower urinary tract reconstruction (augmentation cystoplasty or neobladder). Read More

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http://doi.wiley.com/10.1111/bju.14662
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http://dx.doi.org/10.1111/bju.14662DOI Listing
December 2018
8 Reads

In-hospital cost analysis of prostatic artery embolization compared with transurethral resection of the prostate: post hoc analysis of a randomized controlled trial.

BJU Int 2018 Dec 22. Epub 2018 Dec 22.

Department of Urology, St Gallen Cantonal Hospital, St. Gallen, Switzerland.

Objectives: To perform a post hoc analysis of in-hospital costs incurred in a randomized controlled trial comparing prostatic artery embolization (PAE) and transurethral resection of the prostate (TURP).

Patients And Methods: In-hospital costs arising from PAE and TURP were calculated using detailed expenditure reports provided by the hospital accounts department. Total costs, including those arising from surgical and interventional procedures, consumables, personnel and accommodation, were analysed for all of the study participants and compared between PAE and TURP using descriptive analysis and two-sided t-tests, adjusted for unequal variance within groups (Welch t-test). Read More

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http://dx.doi.org/10.1111/bju.14660DOI Listing
December 2018
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Vitamin D and kidney stones - is there an association?

BJU Int 2018 Dec 21. Epub 2018 Dec 21.

Guy's and St.Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/bju.14658DOI Listing
December 2018
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An updated approach to incremental nerve sparing for robot-assisted radical prostatectomy.

BJU Int 2018 Dec 21. Epub 2018 Dec 21.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Objectives: To update the algorithm for performing incremental nerve sparing (NS) using our multiparametric magnetic resonance imaging (mpMRI)-based nomogram.

Patients And Methods: We applied the coefficients of the nomogram to the observations extracted from our population of patients who underwent robot-assisted radical prostatectomy between February 2014 and October 2015 and who received preoperative mpMRI. The information considered were PSA level, highest side-specific biopsy Gleason grade group, highest ipsilateral percentage core involvement with the highest Gleason grade group, and extracapsular extension (ECE) on mpMRI. Read More

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http://doi.wiley.com/10.1111/bju.14655
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http://dx.doi.org/10.1111/bju.14655DOI Listing
December 2018
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Evaluating the impact of length of time from diagnosis to surgery in patients with unfavourable intermediate-risk to very-high-risk clinically localised prostate cancer.

BJU Int 2018 Dec 20. Epub 2018 Dec 20.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objective: To evaluate the impact of length of time from diagnostic biopsy to radical prostatectomy (RP) on oncological outcomes amongst men diagnosed with unfavourable intermediate- to very-high-risk clinically localised prostate cancer.

Patients And Methods: We performed a retrospective review of men with a diagnosis of grade group (GG) ≥3 prostate cancer on biopsy, who underwent RP within 6 months of diagnosis, at our institution between 2005 and 2018. We assessed patient demographics, pre-biopsy disease characteristics, and receipt of neoadjuvant therapy. Read More

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December 2018
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Aquablating urological skills.

Authors:
Peter Chin

BJU Int 2019 Jan;123(1):2-3

South Coast Urology, Wollongong, NSW, Australia.

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http://dx.doi.org/10.1111/bju.14559DOI Listing
January 2019
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