11,598 results match your criteria BJU international[Journal]


A Risk Calculator Predicting Recurrence in Lymph Node Metastatic Penile Cancer.

BJU Int 2020 Jul 14. Epub 2020 Jul 14.

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

Objectives: To date, no validated prognostic tool is available in patients with penile squamous cell carcinoma (pSCC) and inguinal lymph node metastases (ILNM). We aimed to develop and externally validate a risk calculator for prediction of any cancer recurrence in ILNM pSCC patients.

Materials And Methods: The development cohort included 234pts from 7 referral centers. Read More

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http://dx.doi.org/10.1111/bju.15177DOI Listing

Comparison of iRECIST with RECIST for capturing treatment response of patients with metastatic urothelial carcinoma treated with pembrolizumab.

BJU Int 2020 Jul 13. Epub 2020 Jul 13.

Department of Urology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, Japan, 105-8461.

Objective: To evaluate the clinical usefulness of Immunotherapy Response Evaluation Criteria in Solid Tumors (iRECIST) in patients with metastatic urothelial carcinoma (UC) treated with pembrolizumab. iRECIST is designed to accurately capture the tumor response treated with immunotherapy.

Patients And Methods: We conducted a multicenter retrospective study evaluating the clinical utility of iRECIST in 91 patients with metastatic UC treated with second-line pembrolizumab. Read More

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http://dx.doi.org/10.1111/bju.15176DOI Listing

Avoiding disruption of timely surgical management of genitourinary cancers during the early phase of COVID-19 pandemic.

BJU Int 2020 Jul 13. Epub 2020 Jul 13.

Uro-Gynecological Department, Fondazione "G. Pascale" IRCCS, Naples, Italy.

As of early July 2020, over 10,000,000 confirmed SARS-CoV-2 (COVID-19) cases and 500,000 deaths have been recorded worldwide. This dramatic surge of the pandemic resulted in hospital overcrowding and shortage of intensive care unit (ICU) beds, creating a global crisis in health care systems. As many other specialties, Urology was impacted at different levels. Read More

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http://dx.doi.org/10.1111/bju.15174DOI Listing

Urinary tract stone deaths: data from the Australian and New Zealand Audits of Surgical Mortality.

BJU Int 2020 Jul 11. Epub 2020 Jul 11.

Victorian Audit of Surgical Mortality, Royal Australasian College of Surgeons, Melbourne, Australia.

Objectives: To analyse all mortalities related to surgery for urinary tract calculi in Australia from 1 January 2009- 31 December 2018, and identify common causes, clinical management issues (CMI) and areas for improvement.

Patients And Methods: All urological related deaths reported to ANZASM from 2009 - 2018 were analysed. The Bi-National Audit of Surgical Mortality (BAS) database was interrogated for any involvement with renal, ureteric or bladder stones and all relevant associated data analysed. Read More

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http://dx.doi.org/10.1111/bju.15171DOI Listing

Complications After Open and Robotic-Assisted Radical Prostatectomy and Association with Post-Operative Opioid Use: An Analysis of Data from the PREVENTER Trial.

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Objective: To evaluate perioperative complications for open and robotic-assisted RP for patients enrolled in the PREVENTER trial to determine predictors and impact on opioid consumption.

Patients And Methods: A prospective cohort of 500 patients undergoing open and robotic-assisted RP were followed to determine rates of complications and opioid use. Complications were classified 30 days post-RP using the Clavien-Dindo system. Read More

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http://dx.doi.org/10.1111/bju.15172DOI Listing

Randomised phase II study comparing alternating cycles of sunitinib and everolimus versus standard sequential administration in first-line metastatic renal carcinoma (SUNRISES study).

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

Hospital del Mar-Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.

Background: Alternating blockade of vascular endothelial growth factor receptor (VEGFR) and mammalian target of rapamycin (mTOR) pathways could potentially prevent the occurrence of resistance to anti-VEGFR therapy in metastatic renal cell carcinoma (mRCC).

Methods: SUNRISES, a randomised open-label phase II study, investigated the efficacy of alternating cycles of sunitinib and everolimus compared to standard sequential treatment of sunitinib followed by everolimus upon progression. Treatment-naïve patients with clear-cell mRCC were included. Read More

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http://dx.doi.org/10.1111/bju.15165DOI Listing

Effect of Low Energy Shock Wave Therapy on Intravesical Epirubicin Delivery in a Rat Model of Bladder Cancer.

BJU Int 2020 Jul 12. Epub 2020 Jul 12.

Department of Urology, Urology and Nephrology Center, Mansoura University, Egypt.

Objectives: To study the efficacy of low energy shock wave (LESW) on enhancing intravesical epirubicin (EPI) delivery in a rat model of bladder cancer (BC).

Materials And Methods: 100 female Fischer rats were randomly allocated into five groups; Control, BC, LESW, EPI and EPI plus LESW groups. After BC induction by N-butyl-N-(4-hydroxybutyl)nitrosamine, EPI (0. Read More

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http://dx.doi.org/10.1111/bju.15173DOI Listing

The meaning of words - closing the gap in understanding between doctors and patients in 21 Century consent.

BJU Int 2020 Jul 10. Epub 2020 Jul 10.

Department of Urology, Nuffield Department of Surgical Sciences, Oxford University NHS Hospitals Trust, UK.

"When I use a word" Humpty Dumpty said, in a rather scornful tone, it means just what I choose it to mean, neither more nor less". "The question is" said Alice "whether you can make words mean so many different things". Through the Looking Glass, Lewis Carroll 1872. Read More

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http://dx.doi.org/10.1111/bju.15167DOI Listing

Prospective evaluation of blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer.

BJU Int 2020 Jul 10. Epub 2020 Jul 10.

Department of Urology, University of Southern California, Los Angeles, CA, United States.

Objectives: To evaluate the utility of blue light flexible cystoscopy (BLFC) for surveillance of non-muscle invasive bladder cancer (NMIBC).

Methods: Prospective cohort of consecutive patients who underwent office BLFC for NMIBC. Clinical information was collected including cystoscopic findings and pathologic data. Read More

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http://dx.doi.org/10.1111/bju.15166DOI Listing

The effect of Losartan on the recoverability of renal function in anuric and oliguric patients with solitary obstructed kidney: A double blind randomized placebo-controlled trial.

BJU Int 2020 Jul 10. Epub 2020 Jul 10.

Urology department. Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Objectives: To assess the role of Angiotensin receptor blockade (ARB), losartan, on the recoverability of renal function after deobstruction in anuric and oliguric patients.

Materials And Methods: This is a double-blind randomized placebo-controlled trial on anuric or oliguric patients with calculuar obstruction of solitary kidney. Patients with anomalous kidney or those with ASA score of >3 were excluded. Read More

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http://dx.doi.org/10.1111/bju.15168DOI Listing

Urology surgical activity and COVID-19: Risk assessment at the epidemic peak the parisian multicenter experience.

BJU Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Urology, UPEC - Henri Mondor , Hospital - AP-HP, Paris, France.

Objectives: To evaluate the risk of contracting severe COVID-19, defined as COVID-19 specific intensive care unit (ICU) admission or death, for patients undergoing urological surgery during the epidemic. To define consequences of receiving surgery for COVID-19 patients.

Patients And Methods: This is a multicenter observational cohort study. Read More

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http://dx.doi.org/10.1111/bju.15164DOI Listing
July 2020
3.533 Impact Factor

The Cancer of the Bladder Risk Assessment (COBRA) score for Estimating Cancer-Specific Survival after Radical Cystectomy: External Validation in a Large Bi-institutional Cohort.

BJU Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Objective: To perform an external validation of the Cancer of the Bladder Risk Assessment (COBRA) score for estimating cancer-specific survival (CSS) after radical cystectomy (RC) in a large bi-institutional cohort of patients.

Patients And Methods: Patients treated with RC and lymph node dissection (LND) between May 1996 and July 2017 were retrieved from the RC databases of Leuven and Turin. Collected variables were age at RC, tumor stage, lymph node (LN) density, neoadjuvant chemotherapy, the extent of LND, and nodal stage. Read More

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http://dx.doi.org/10.1111/bju.15163DOI Listing

Safety and feasibility of early single dose mitomycin-C bladder instillation post robot-assisted radical nephroureterectomy.

BJU Int 2020 Jul 7. Epub 2020 Jul 7.

Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, United Kingdom.

Objectives: To assess the safety and feasibility of early single dose mitomycin-C (MMC) bladder instillation following robot-assisted radical nephroureterectomy (RANU) at a tertiary kidney cancer centre. Radical nephroureterectomy with bladder cuff excision and subsequent mitomycin-C (MMC) bladder instillation to reduce recurrence risk is the gold standard for high risk upper urinary tract urothelial carcinoma (UUTUC). We adapted a robot-assisted nephroureterectomy technique with precise distal ureteric dissection, bladder cuff excision and watertight bladder closure. Read More

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http://dx.doi.org/10.1111/bju.15162DOI Listing

Randomized trial of bipolar resection vs. Holmium laser enucleation vs. Greenlight laser vapo-enucleation of the prostate for treatment of large sized benign prostate obstruction; 3-years outcome.

BJU Int 2020 Jul 6. Epub 2020 Jul 6.

Mansoura Urology and Nephrology Center, Egypt.

Purpose: To assess the non-inferiority of transurethral resection in saline (TURis) and Greenlight laser Vapo-Enucleation of the prostate (GL.PVEP) to Holmium laser enucleation of the prostate (HoLEP) for controlling lower urinary tract symptoms secondary to large sized BPH with comparable 3-years-retreatment rate.

Methods: Eligible patients with BPH (80-150ml) were randomly assigned to one of the intervention groups. Read More

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http://dx.doi.org/10.1111/bju.15161DOI Listing

Prostate Cancer Survivorship Essentials Framework: Guidelines for Practitioners.

BJU Int 2020 Jul 5. Epub 2020 Jul 5.

Division of Research and Innovation, University of Southern Queensland, Springfield, QLD, Australia.

Objective: To develop contemporary and inclusive prostate cancer survivorship guidelines for the Australian setting.

Subjects/patients And Methods: A four round iterative Policy Delphi was utilised with a 47-member expert panel that included leaders from key Australian and New Zealand clinical and community groups and consumers from diverse backgrounds including LGBTQIA, regional, rural and urban settings. The first three rounds were undertaken using an online survey (94% to 96% response) followed by a fourth final face-to-face panel meeting. Read More

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http://dx.doi.org/10.1111/bju.15159DOI Listing

Early outcomes of Single Port Robotic Radical Prostatectomy.Lessons Learned from The learning curve experience.

BJU Int 2020 Jul 4. Epub 2020 Jul 4.

AdventHealth Global Robotics Institute, Celebration, FL, USA.

Objective: To describe the crucial factors related to the implementation of the da Vinci SP system, and the early outcomes after the introduction of this robot for radical prostatectomy (RARP).

Materials And Methods: We prospectively collected the data from 50 consecutive patients with prostate adenocarcinoma who underwent RARP with this robot. The median follow-up was 53 days. Read More

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http://dx.doi.org/10.1111/bju.15158DOI Listing

Survival Following Cytoreductive Nephrectomy: A Comparison of Existing Prognostic Models.

BJU Int 2020 Jul 4. Epub 2020 Jul 4.

The University of Texas, M.D. Anderson Cancer Center, Department of Urology, USA.

Objective: To validate models currently used to predict metastatic renal cell carcinoma (mRCC) outcomes in a cohort of patients undergoing cytoreductive nephrectomy (CN).

Patients And Methods: Ten renal cell carcinoma (RCC) prognostic models (International Metastatic RCC Database Consortium [IMDC]; Memorial Sloan Kettering Cancer Center [MSKCC]; Culp; Leibovich; University of California at Los Angeles Integrated Staging System [UISS]; Stage, Size, Grade, and Necrosis [SSIGN]; Yaycioglu; Karakiewicz; Cindolo; and Margulis) were chosen based on clinical relevance and use in clinical trial design. Model validation was performed using patients who underwent CN at a single institution between 2005 and 2017 and model discrimination (ability to select patients at risk of death) was assessed. Read More

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http://dx.doi.org/10.1111/bju.15160DOI Listing

Super-mini Percutaneous Nephrolithotomy (SMP) vs Standard Percutaneous Nephrolithotomy (sPNL) for the management of renal calculi < 2 cm: a randomized controlled study.

BJU Int 2020 Jul 3. Epub 2020 Jul 3.

Department of Urology, Kasturba Hospital, Manipal, MAHE, India.

Objective: To compare efficacy and safety between standard and super-mini PNL (SMP).

Patients & Methods: 150 patients presenting with renal calculi < 2 cm were randomized to standard (group 1) or SMP group (group 2). Randomization was based on centralized computer-generated numbers. Read More

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http://dx.doi.org/10.1111/bju.15144DOI Listing

Long live the BJUI.

Authors:
Prokar Dasgupta

BJU Int 2020 Jul;126(1):1-2

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http://dx.doi.org/10.1111/bju.15128DOI Listing

HoLEP is the complete technique for treating BPH.

Authors:
Peter J Gilling

BJU Int 2020 Jul;126(1)

Bay of Plenty District Health Board Clinical School, Tauranga, New Zealand.

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http://dx.doi.org/10.1111/bju.15099DOI Listing

Case of the Month from Memorial Sloan Kettering Cancer Center, New York: Managing newly-diagnosed metastatic testicular germ cell tumor in a COVID-19 positive patient.

BJU Int 2020 Jul 1. Epub 2020 Jul 1.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

A 17-year-old young man with history of a congenital solitary left testis presented to our clinic in late April 2020 with left testicular swelling and discomfort over the preceding few weeks. The patient denied unintentional weight loss or nipple tenderness but reported new, mild left-sided back discomfort. His medical history was notable for asthma and a congenitally absent right testis for which he underwent negative surgical exploration in childhood. Read More

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http://dx.doi.org/10.1111/bju.15157DOI Listing

Ethnic and Socioeconomic disparities in Prostate Cancer Screening - Lessons from New Zealand.

BJU Int 2020 Jun 29. Epub 2020 Jun 29.

Department of Surgery, the University of Auckland, New Zealand.

Objectives: To investigate the presence of ethnic and socioeconomic disparities in Prostate cancer screening and identify its impact on cancer outcomes.

Materials And Methods: From January 2008 to December 2017, all men in the Northern region of New Zealand, who had a Prostate Specific Antigen (PSA) test performed in the community, were identified from the electronic laboratory reports database. Asymptomatic men, with no known diagnosis of Prostate cancer, were included. Read More

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http://dx.doi.org/10.1111/bju.15155DOI Listing

The role of novel minimally invasive treatments for lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH).

BJU Int 2020 Jun 29. Epub 2020 Jun 29.

Department of Urology, St. Antonius Hospital, Gronau, Germany.

Objectives: To provide an update on novel minimally invasive LUTS/BPH treatments in a non-systematic review. To define potential target populations for the various new minimally invasive treatments.

Methods: Recent literature, meta-analyses and guideline recommendations for aquablation (AquaBeam ), water vapour thermal therapy (Rezūm ), prostate artery embolization (PAE), prostatic urethral lift (UroLift ) and the nitinol butterfly-like stent (i-TIND ) were reviewed. Read More

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http://dx.doi.org/10.1111/bju.15154DOI Listing

Solitary rib lesions showing PSMA uptake in pre-treatment staging Ga-PSMA-11 PET scans for men with prostate cancer: benign or malignant?

BJU Int 2020 Jun 27. Epub 2020 Jun 27.

Wesley Hospital, Brisbane, Queensland, Australia.

Objectives: To determine the proportion of solitary rib lesions on pre-treatment Gallium-labelled prostate-specific membrane antigen (PSMA)/CT scans in men with prostate cancer that are malignant and examine any predictive factors.

Patients And Methods: This retrospective single tertiary referral institution cohort study of men reviewed the results of Ga-PSMA-11 PET/CT scans performed for primary staging prior to treatment of prostate cancer from July 2014 to September 2019. Men with PSMA uptake outside the prostate in only the rib lesion were included. Read More

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http://dx.doi.org/10.1111/bju.15152DOI Listing

Use of PSMA PET/CT in Response Assessment Following Upfront Chemohormonal Therapy in Metastatic Prostate Cancer.

BJU Int 2020 Jun 24. Epub 2020 Jun 24.

Walter and Eliza Hall Institute, Melbourne, Australia.

Prostate-specific membrane antigen (PSMA) PET/CT imaging is increasingly being utilised in clinical practice, demonstrating greater sensitivity in the detection of metastatic prostate cancer (mPC) compared to conventional imaging [1]. Prior studies have primarily focussed on its use following biochemical recurrence to detect oligometastatic disease potentially amenable to salvage therapies [2-4]. However, the role of PSMA PET/CT in assessing treatment response remains unclear. Read More

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http://dx.doi.org/10.1111/bju.15151DOI Listing
June 2020
3.533 Impact Factor

Transurethral en bloc submucosal hydrodissection versus conventional resection for resection of non-muscle invasive bladder cancer (HYBRIDBLUE): a randomized, multicentre trial.

BJU Int 2020 Jun 23. Epub 2020 Jun 23.

Department of Urology, University Hospital of Tübingen, Tübingen, Germany.

Objective: To determine whether transurethral en bloc submucosal hydrodissection of bladder tumours (TUEB) improves the quality of the resection compared to conventional transurethral resection (TURBT) in patients with NMIBC.

Patients And Methods: A randomized, multicentre trial (HYBRIDBLUE) was conducted in a superiority design. Six German academic centres participated between 09/2012 and 08/2015. Read More

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http://dx.doi.org/10.1111/bju.15150DOI Listing

Non-invasive and surgical interventions of penile enhancement for aesthetic or therapeutic purposes: a systematic review.

BJU Int 2020 Jun 23. Epub 2020 Jun 23.

Urology Department, Hospital Universitario 12 Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.

Introduction: Despite the lack of guidelines, a wide variety of non-invasive and surgical interventions for penile enhancement with aesthetic and therapeutic purposes is available.

Aim: To systematically review the literature in order to investigate the efficacy and safety of surgical and non-invasive penile enhancement procedures for aesthetic and therapeutic purposes.

Methods: A systematic research investigating penile enhancement procedures was performed using the MEDLINE database. Read More

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http://dx.doi.org/10.1111/bju.15145DOI Listing

A prospective, matched comparison of ultra-low and standard-dose computed tomography for assessment of renal colic.

BJU Int 2020 Jun 23. Epub 2020 Jun 23.

Nepean Urology Research Group, Kingswood, NSW, Australia.

Objective: To determine the diagnostic accuracy of ultra-low-dose computed tomography (ULDCT) compared with standard-dose CT (SDCT) in the evaluation of patients with clinically suspected renal colic, in addition to secondary features (hydroureteronephrosis, perinephric stranding) and additional pathological entities (renal masses).

Patients And Methods: A prospective, comparative cohort study was conducted amongst patients presenting to the emergency department with signs and symptoms suggestive of renal or ureteric colic. Patients underwent both SDCT and ULDCT. Read More

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http://dx.doi.org/10.1111/bju.15116DOI Listing

Single-layered versus multiple-layered wound closure for flank incision: Results of a prospective, randomized, double-blinded multicenter study.

BJU Int 2020 Jun 21. Epub 2020 Jun 21.

Department of Urology, University Hospital Manheim, Mannheim, Germany.

Objective: To compare the incidence of postoperative flank bulges between patients with multiple-layer closure and single superficial-layer closure after retroperitoneal surgery via open flank incision.

Patients And Methods: The study was a randomized controlled, patient- and assessor-blinded, multicenter trial. Between May 2015 and February 2017, 225 patients undergoing flank incision were randomized 1:1 to a multiple-layered closure (SIMULAC-I) and a single superficial layered closure (SIMULAC-II) group. Read More

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http://dx.doi.org/10.1111/bju.15148DOI Listing

The recurrence and progression risk after simultaneous endoscopic surgery of urothelial bladder tumor and benign prostatic hyperplasia; a systematic review and meta-analysis.

BJU Int 2020 Jun 21. Epub 2020 Jun 21.

Department of Urology, Medical University of Vienna, Vienna, Austria.

Objectives: A simultaneous surgery for bladder cancer and benign prostatic hyperplasia (BPH) is not an unusual scenario. Theoretically, simultaneous transurethral resection of bladder tumor (TURBT) and transurethral resection of the prostate (TURP) can lead to an increased risk of recurrence in the bladder neck and prostatic urethra (BN/PU). We aimed to evaluate recurrence and progression risk after simultaneous endoscopic surgery of bladder cancer and BPH. Read More

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http://dx.doi.org/10.1111/bju.15146DOI Listing

Are urologists in trouble by SARS-CoV-2? Reflexions and recommendations for specific interventions.

BJU Int 2020 Jun 19. Epub 2020 Jun 19.

Medical University Innsbruck, Department of Urology, Anichstrasse 35, 6020, Innsbruck, Austria.

Objective: We aim to assess the risk of infection during urologic surgeries. Therefore possible hazards in tissue, blood, urine and aerosolized particles generated during surgery, are evaluated. Understanding the risk, recommendations for clinical practice are provided. Read More

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http://dx.doi.org/10.1111/bju.15141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323234PMC

Functional outcomes post pyeloplasty in solitary renal units. Structured analysis with the implication of AKIN staging criteria to predict long term renal function recoverability.

BJU Int 2020 Jun 19. Epub 2020 Jun 19.

Urology department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Objectives: To assess the long-term functional outcomes post pyeloplasty in solitary kidney (SK) models and to define factors affecting postoperative renal function recoverability in adults.

Materials And Methods: A retrospective evaluation of all adult patients who underwent pyeloplasty for UPJO in SK was done. Long term renal function was assessed by diuretic scintigraphy and morphological changes were also determined e. Read More

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http://dx.doi.org/10.1111/bju.15142DOI Listing

PSMA Theranostics in advanced prostate cancer: an evolving option.

BJU Int 2020 Jun 19. Epub 2020 Jun 19.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Australia.

Prostate-specific membrane antigen (PSMA) has significantly altered the global landscape of prostate cancer imaging in recent years due to its reported high sensitivity and specificity. Evidence for the use of PSMA PET at both the staging and restaging settings is promising, and novel applications such as radio-guided surgery add further value to this exciting imaging modality. However, PSMA has yet wider applications that extend away from diagnostics and into therapeutics: the so-called "theranostic" approach. Read More

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http://dx.doi.org/10.1111/bju.15143DOI Listing

Robot-assisted laparoscopic artificial urinary sphincter insertion in women with stress urinary incontinence: a pilot single-center study.

BJU Int 2020 Jun 19. Epub 2020 Jun 19.

Sorbonne Université, Department of Urology, Pitié-Salpêtrière Academic Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Objective: To report the functional outcomes of robot-assisted laparoscopic artificial urinary sphincter (AUS, AMS 800 ) implantation and revision in women with stress urinary incontinence.

Materials And Methods: A pilot prospective monocentric study included all consecutive female patients suffering from stress urinary incontinence and undergoing an AUS surgery (implantation or revision) using a robotic approach between 2012 and 2018. The AUS was implanted through a transperitoneal robotic approach. Read More

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http://dx.doi.org/10.1111/bju.15147DOI Listing

Management of benign prostatic hyperplasia in the 21st century: temporal trends in Australian population-based data.

BJU Int 2020 Jun 17. Epub 2020 Jun 17.

Department of Urology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

Objective: To examine national trends in the medical and surgical treatment of benign prostatic hyperplasia (BPH) using Australian Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS) population data from 2000 to 2018.

Patients And Methods: Annual data was extracted from the MBS, PBS and Australian Institute of Health and Welfare databases for the years 2000-2018. Population-adjusted rates of BPH procedures and medical therapies were calculated and compared in relation to age. Read More

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http://dx.doi.org/10.1111/bju.15098DOI Listing

The Cost-Effectiveness of Transurethral resection of the prostate versus Thulium laser transurethral vaporesection of the prostate in the UNBLOCS randomised controlled trial for benign prostatic obstruction.

BJU Int 2020 Jun 17. Epub 2020 Jun 17.

Bristol Randomised Trials Collaboration (BRTC), Bristol Trials Centre, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.

Objective: To determine the cost-effectiveness of the current gold standard operation of transurethral resection of the prostate (TURP) compared to the new laser technique of thulium laser transurethral vaporesection of the prostate (ThuVARP) in men with benign prostatic obstruction (BPO) within the United Kingdom (UK) National Health Service (NHS).

Patients And Methods: The trial was conducted across seven UK centres (four university teaching hospitals and three district general hospitals). 410 men aged 18 years and older presenting with either bothersome lower urinary tract symptoms (LUTS) or urinary retention secondary to BPO, and suitable for surgery, were randomised (whilst under anaesthetic) 1:1 to receive the TURP or ThuVARP procedure. Read More

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http://dx.doi.org/10.1111/bju.15138DOI Listing

The dramatic COVID-19 outbreak in italy is responsible of a huge drop in urological surgical activity: A multicenter observational study.

BJU Int 2020 Jun 18. Epub 2020 Jun 18.

Azienda Ospedaliero Universitaria Careggi, Firenze, Italy.

Objective: Italy is facing the COVID-19 outbreak with an abrupt reorganization of its national health-system, in order to augment care provision to symptomatic patients. The sudden shift of personnel and resources towards COVID-19 care has led to the reduction of surgery, with possible severe drawbacks. The aim of the study is to describe the trend in surgical volume in urology, in Italy. Read More

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http://dx.doi.org/10.1111/bju.15149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322984PMC

Guidelines for Reporting of Figures and Tables for Clinical Research in Urology.

BJU Int 2020 Jul 15;126(1):14-25. Epub 2020 Jun 15.

Vanderbilt University School of Medicine, Nashville, TN, USA.

In an effort to improve the presentation of and information within tables and figures in clinical urology research, we propose a set of appropriate guidelines. We introduce six principles: (1) include graphs only if they improve the reader's ability to understand the study findings; (2) think through how a graph might best convey information, do not just select a graph from preselected options on statistical software; (3) do not use graphs to replace reporting key numbers in the text of a paper; (4) graphs should give an immediate visual impression of the data; (5) make it beautiful; and (6) make the labels and legend clear and complete. We present a list of quick "dos and don'ts" for both tables and figures. Read More

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http://dx.doi.org/10.1111/bju.15102DOI Listing

A clinical pathway for the management of Peyronie's disease: integrating clinical guidelines from the International Society of Sexual Medicine, American Urological Association and European Urological Association.

BJU Int 2020 Jun 16. Epub 2020 Jun 16.

Urology South, Moorabbin, Vic., Australia.

Objective: To provide a clinical framework and key guideline statements to assist clinicians in the evidence-based management of Peyronie's disease (PD).

Methods: We conducted a review of the published literature relevant to PD management, with an emphasis on published clinical guidelines. References used in the text have been assessed according to their level of evidence, and guideline recommendations have been graded based on the Oxford Centre for Evidence-based Medicine Levels of Evidence. Read More

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http://dx.doi.org/10.1111/bju.15057DOI Listing
June 2020
3.533 Impact Factor

A Systematic Review on Mutation Markers for Bladder Cancer Diagnosis in Urine.

BJU Int 2020 Jun 15. Epub 2020 Jun 15.

Department of Urology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Objectives: To systematically summarize the available evidence on urinary bladder cancer (BC) mutation markers. Gene mutations are expected to provide novel biomarkers for urinary BC diagnosis. So far, evidence on urinary BC mutation markers has not proven sufficient to be adopted by clinical guidelines. Read More

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http://dx.doi.org/10.1111/bju.15137DOI Listing

Personalized Biopsy Schedules Based on Risk of Gleason Upgrading for Low-Risk Prostate Cancer Active Surveillance Patients.

BJU Int 2020 Jun 12. Epub 2020 Jun 12.

Department of Biostatistics, Erasmus University Medical Center, Rotterdam, the Netherlands.

Objective: To develop a model and methodology for predicting the risk of Gleason upgrading in prostate cancer active surveillance (AS) patients, and using the predicted risks to create risk-based personalized biopsy schedules as an alternative to one-size-fits-all schedules (e.g., annually). Read More

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http://dx.doi.org/10.1111/bju.15136DOI Listing

Ga-PSMA-PET/CT helps to select patients for salvage radical prostatectomy with local recurrence after primary radiotherapy for prostate cancer.

BJU Int 2020 Jun 12. Epub 2020 Jun 12.

Department of Urology, Uro-Oncology and robot assisted surgery University Hospital of Cologne, Cologne, Germany.

Objective: To investigate the diagnostic performance of 68Ga-PSMA PET/CT in patients with recurrent prostate cancer with regard to the presence of lymph node metastases and local recurrences after primary radiotherapy.

Subject/patients And Methods: We retrospectively reviewed 142 patients following sRPE, 50 of which had a 68Ga-PSMA PET/CT performed as a preoperative staging module. Predictive clinical parameters were analyzed in a multivariate cox regression analysis. Read More

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http://dx.doi.org/10.1111/bju.15135DOI Listing

Histological comparison between predictive value of pre-operative 3T multiparametric MRI and Ga-PSMA PET/CT scan for pathological outcomes at radical prostatectomy and pelvic lymph node dissection for prostate cancer.

BJU Int 2020 Jun 10. Epub 2020 Jun 10.

The Wesley Hospital.

Objective: To evaluate the ability of pre-operative multiparametric MRI (mpMRI) and a positron emission tomography prostate specific membrane antigen tracer (68Ga-PSMA PET/CT) scan to predict pathological outcomes and also identify a group of men with a <5% risk of histological pelvic lymph node metastasis (LNM) at pelvic lymph node dissection (PLND) performed during a robot assisted laparoscopic radical prostatectomy (RALP) for prostate cancer. We then aimed to compare these results to known risk calculators for LNM, including CAPRA score, MSKCC and Briganti nomograms.

Methods: Between July 2014 and September 2019 only men who had both a pre-operative mpMRI and staging 68Ga-PSMA PET/CT at our institution followed by a radical prostatectomy with PLND referred to a single specialist uro-pathology laboratory were considered for inclusion. Read More

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http://dx.doi.org/10.1111/bju.15134DOI Listing
June 2020
3.533 Impact Factor

Not All Prostate Cancer is the Same - Patient perceptions: An Asia-Pacific study.

BJU Int 2020 Jun 10. Epub 2020 Jun 10.

The Janssen Pharmaceutical Companies of Johnson & Johnson, Asia Pacific, Kowloon, Hong Kong.

Introduction And Objective: While extensive quantitative research has been undertaken into outcomes of treatments for prostate cancer, little in the way of qualitative research has been performed looking at subjective perceptions of patients in regard to their perceived deficits in the treatment of this condition. Such research is particularly lacking in reference to the Asia Pacific Region.

Patients And Methods: Initial 45 minute qualitative research interrogatory interviews were conducted with 12 patients from Australia, China and Japan to identify themes that were significant to patients in the management of prostate cancer. Read More

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http://dx.doi.org/10.1111/bju.15129DOI Listing

Randomized Comparison of Techniques for Control of the Dorsal Venous Complex During Robotic-assisted Laparoscopic Radical Prostatectomy.

BJU Int 2020 Jun 10. Epub 2020 Jun 10.

Swedish Medical Center, Department of Urology, Seattle, WA.

Objective: To prospectively compare the effects of endoscopic stapling, division and suture ligation, and suture ligation with suspension of the dorsal venous complex (DVC) on continence during RARP PATIENTS AND METHODS: 300 consecutive patients undergoing RARP by a single surgeon were randomized to three groups: endoscopic stapling, cut and suture ligation, and suture ligation with suspension. The only difference between the groups was the technique to control the DVC. Pad-free continence (PFC) and overall continence (0 pads/day with or without security pad) was assessed with patient reported pad usage records and validated questionnaires (EPIC) at 3, 12, and 15 months. Read More

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http://dx.doi.org/10.1111/bju.15133DOI Listing

Preoperative frailty and outcome in patients undergoing radical cystectomy.

BJU Int 2020 Jun 8. Epub 2020 Jun 8.

Department of Anesthesiology and Intensive Care, St. Antonius Hospital, Nieuwegein, The Netherlands.

Objective: To determine the value of preoperative frailty screening in predicting postoperative severe complications and 1 year mortality in patients undergoing radical cystectomy.

Methods: Prospective cohort single centre study in patients undergoing radical cystectomy from September 2016-December 2017. Preoperative frailty screening was implemented as standard care and was used to guide shared decision making during multidisciplinary team meeting. Read More

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http://dx.doi.org/10.1111/bju.15132DOI Listing

Comparison of S.T.O.N.E. score vs Guy's stone score vs Clinical Research Office of the Endourological Society (CROES) score as predictive tools of percutaneous nephrolithotomy outcome: a prospective study.

BJU Int 2020 Jun 7. Epub 2020 Jun 7.

Urology Department, Muljibhai Patel Urological Hospital, Dr Virendra Desai Road, Nadiad, Gujarat, India, 387001.

Introduction: Percutaneous nephrolithotomy (PCNL) is a commonly practiced method of renal stone removal. Guy's Stone Score (GSS), S.T. Read More

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http://dx.doi.org/10.1111/bju.15130DOI Listing

Favorable Multi-Institutional Experience with Penoscrotal Decompression for Prolonged Ischemic Priapism.

BJU Int 2020 Jun 5. Epub 2020 Jun 5.

University of Texas Southwestern Medical Center, Department of Urology, Dallas, Texas, United States.

Objectives: To report our multi-institutional experience using penoscrotal decompression (PSD) for surgical treatment of prolonged ischemic priapism (PIP).

Materials And Methods: We retrospectively reviewed clinical records for PIP patients treated with PSD from 2017-2020. Priapisms were confirmed as ischemic based on clinical presentations and cavernosal blood gas abnormalities. Read More

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http://dx.doi.org/10.1111/bju.15127DOI Listing

The Clinical Features and Predictive Factors of Nocturnal Enuresis in Adult Men.

BJU Int 2020 May 31. Epub 2020 May 31.

Bristol Urological Institute, Southmead Hospital, Bristol, UK.

Objectives: To characterize the clinical features and to discover predictive factors of adult male with nocturnal enuresis (NE).

Subjects And Methods: Forty-three eligible adult male subjects (mean age was 57.8 years), were recruited prospectively over a 2-year period. Read More

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http://dx.doi.org/10.1111/bju.15126DOI Listing