10,967 results match your criteria BJU international[Journal]


An Updated Systematic Review and Meta-analysis: Clinical Outcome of Single-Incision Slings Excluding TVT-Secur versus Standard Slings in Surgical Management of Stress Incontinence.

BJU Int 2018 Jun 21. Epub 2018 Jun 21.

Department of Urology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Objectives: To assess and compare the long-term efficacy and safety of single-incision mini-slings (SIMS) except tension-free vaginal tape (TVT)-Secur with standard midurethral slings (SMUS) for female stress urinary incontinence through an updated systematic review and meta-analysis of randomized controlled trials (RCTs) comparing these 2 surgical methods.

Materials And Methods: A literature review of all RCTs comparing SIMS (Mini-Arc, Contasure-Needleless, Ophira, Tissue Fixation System, and Ajust) except TVT-Secur with SMUS was performed. The Medline, Embase, Scopus, Web of Science, and Cochrane Controlled Trial Register databases were reviewed. Read More

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FERTILITY MANAGMENT IN TESTICULAR CANCER- The need for establishing a standardised and evidenced based patient centric pathway.

BJU Int 2018 Jun 19. Epub 2018 Jun 19.

GKT School of Medical Education, King's College London, Great Maze Pond, London, SE1 9RT.

Objectives: To determine the impact of testicular cancer and its treatments on fertility and to review the current management options for the infertile, testicular cancer patient, both before diagnosis and after treatment, with the aim to provide practical recommendations to update contemporary guidelines and standardise clinical practice.

Patients And Methods: Searches for relevant articles on Pubmed and Google Scholar between 2000-2017, with additional articles sourced from reference lists of included publications.

Results: At time of diagnosis, 6%- 24% of testicular cancer patients are azoospermic and 50% are oligozoospermic. Read More

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Penile blood pressure is useful to identify candidates for tadalafil treatment in patients with lower urinary tract symptoms.

BJU Int 2018 Jun 19. Epub 2018 Jun 19.

Tohoku University Graduate School of Medicine.

Objectives: The phosphodiesterase type 5 inhibitor tadalafil is one of the first-choice drugs for benign prostate hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS). However, tadalafil is not always equally beneficial to every patient. In order to determine whether penile blood pressure (PBP) can be used to identify patients who can benefit from tadalafil treatment, the correlation between PBP at baseline and changes in LUTS induced by tadalafil treatment was studied prospectively. Read More

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June 2018
2 Reads

Can surgical reconstruction of vaginal and ligamentous laxity cure over active bladder symptoms in women with pelvic organ prolapse?

BJU Int 2018 Jun 16. Epub 2018 Jun 16.

Member of Ethics Committee, Faculty of Medicine, Ludwig-Maximilian University of Munich.

Objective: The objective of this interventional study was to examine extent and intensity of the coexistence of overactive bladder (OAB) symptoms in women with pelvic organ prolapse (POP) and to evaluate the likelihood of OAB symptom improvement after surgical POP reconstruction in a period of two years.

Patients And Methods: The effectiveness of the transvaginal, single-incision Elevate@ technique for anatomical cure of anterior/apical and posterior/apical vaginal prolapse has been previously reported following a prospective, multicenter study. This technique utilizes mesh arms attached to the sacrospinous ligaments to recreate apical ligamentous support. Read More

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Alpha-blockers as medical expulsive therapy for ureteral stones: a Cochrane Systematic Review.

BJU Int 2018 Jun 16. Epub 2018 Jun 16.

Department of Urology, University Medical Center Utrecht, Utrecht, Netherlands.

Objectives: To assess the effects of alpha-blockers compared to standard therapy or placebo for ureteral stones 1 cm and less confirmed by imaging in adult patients presenting with symptoms of ureteral stone disease.

Patients And Methods: We performed a systematic search in multiple databases and grey literature with no restrictions on the language of publication or publication status, up until November 2017. We included randomised controlled trials evaluating ureteral stone passage in adult patients, that compared alpha-blockers with standard therapy or placebo. Read More

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June 2018
1 Read

Hospitalization and Readmission Costs after Radical Cystectomy in a Nationally Representative Sample: Does Urinary Reconstruction Matter?

BJU Int 2018 Jun 13. Epub 2018 Jun 13.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objectives: To investigate the impact of continent urinary diversion on readmissions and hospital costs in a nationally representative sample of radical cystectomies (RC) performed in the United States.

Materials & Methods: The 2010-2014 Nationwide Readmissions Database was queried for patients with a diagnosis of bladder cancer who underwent RC. We identified patients undergoing continent (neobladder or continent cutaneous reservoir) or incontinent (ileal conduit) diversions. Read More

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The United States Opioid Epidemic: A Review of the Surgeon's Contribution and Health Policy Initiatives.

BJU Int 2018 Jun 13. Epub 2018 Jun 13.

Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213.

Opioid abuse, addiction, and death have reached epidemic proportions in the United States. Communities wear the devastation of the crisis in there pockmarked geography where addiction has increased homelessness and abandoned homes. Rural communities have fractured under the burden while urban centers struggle to contain open market drug dealing. Read More

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June 2018
2 Reads

Can we still recommend tension-free vaginal tape for long-term safety and efficacy?

Authors:
Linda Cardozo

BJU Int 2018 Jul;122(1):5-6

Department of Urogynaecology, King's College Hospital, London, UK.

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The trials of doing trials: will the prostatic stent rise from the dead?

Authors:
Tom McNicholas

BJU Int 2018 Jul;122(1):4-5

Pinehill Hospital, Hitchin, Herts, UK.

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Antibiotics and ureteroscopy: a single prophylactic dose is enough, but could we give even less?

BJU Int 2018 Jul;122(1):3-4

Clinical Microbiology, UCLH NHS Foundation Trust, London, UK.

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Multiparametric magnetic resonance imaging (MRI) with targeted fusion biopsy: is the time now?

BJU Int 2018 Jul;122(1):1-2

Department of Urological Surgery, Vanderbilt University, Nashville, TN, USA.

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Overcoming difficulties with equipoise to enable recruitment to a randomised controlled trial of partial ablation versus radical prostatectomy for unilateral localised prostate cancer.

BJU Int 2018 Jun 11. Epub 2018 Jun 11.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Objective: To describe how clinicians conceptualised equipoise in the PART (Partial prostate Ablation versus Radical prosTatectomy in intermediate risk, unilateral clinically localised prostate cancer) feasibility study and how this affected recruitment.

Subjects And Methods: PART included a QuinteT Recruitment Intervention (QRI) to optimise recruitment. Phase I aimed to understand recruitment, and included scrutinising recruitment data, interviewing the Trial Management Group and recruiters (n=13), and audio-recording recruitment consultations (n=64). Read More

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Phosphodiesterase-5 in men with vasculogenic and post-radical prostatectomy erectile dysfunction: Is there a molecular difference?

BJU Int 2018 Jun 11. Epub 2018 Jun 11.

The James Buchanan Brady Urological Institute, and Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland.

Objectives: To clarify the molecular basis of penile erection at the human level and distinguish mechanisms underlying vasculogenic and post-radical prostatectomy (post-RP) erectile dysfunction (ED) subtypes.

Patients And Methods: Erectile tissue was obtained from men without histories of ED who underwent penile surgery for Peyronie's disease (control, n=5) and with ED who underwent penile prosthesis implantation (n=17). ED was categorized into vasculogenic (n=8) and post-RP (n=9) subtypes. Read More

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The rise of the clinical entrepreneur.

Authors:
Tony Young

BJU Int 2018 Jun;121(6):819

Innovation NHS England, UK.

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The British Association of Urological Surgeons (BAUS) consensus documents on andrology.

Authors:
Prokar Dasgupta

BJU Int 2018 Jun;121(6):820

MRC Centre for Transplantation, King's College London, London, UK.

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Robot-assisted radical prostatectomy and a parachute.

BJU Int 2018 Jun;121(6):820-821

Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA.

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June 2018
1 Read

β -adrenoceptor agonists inhibit calcium oscillations in bladder detrusor.

Authors:
L M McLatchie

BJU Int 2018 Jun;121(6):821-822

Department of Urology, Guy's Hospital, London, UK.

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Time to link compensation to best practice?

BJU Int 2018 May;121 Suppl 3

Department of Surgery, Austin Hospital and Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Vic., Australia.

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Both acute and chronic inflammation are associated with lower perineural invasion in men with prostate cancer on repeat biopsy.

BJU Int 2018 Jun 6. Epub 2018 Jun 6.

Department of Urology, University of Illinois at Chicago, Chicago, IL, USA.

Objectives: To evaluate the association between acute and chronic inflammation with the presence of perineural invasion (PNI) in prostate biopsies positive for prostate cancer (PCa).

Material And Methods: Retrospective analysis of 1399 prostate biopsies positive for PCa in the Reduction by Dutasteride of PCa Events (REDUCE) study. PCa, acute and chronic prostate inflammation, and PNI were assessed by central pathology review. Read More

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Super-mini percutaneous nephrolithotomy (SMP) versus retrograde intrarenal surgery for the treatment of 1-2 cm lower-pole renal calculi: an international multicenter randomized controlled trial.

BJU Int 2018 Jun 6. Epub 2018 Jun 6.

Department of Urology, Dr. Lutfi KIRDAR Kartal Research and Training Hospital, Istanbul, Turkey.

Objectives: To compare the safety and efficacy of super-mini-percutaneous nephrolithotomy (SMP) and retrograde intrarenal surgery (RIRS) for the treatment of 1-2 cm lower-pole renal calculi (LPC).

Patients And Methods: An international multicenter, prospective, randomized, non-blinded controlled study was conducted at 10 academic medical centers in China, India, and Turkey between August 2015 and June 2017. A total of 160 consecutive patients with 1-2 cm LPC were randomized to receive SMP or RIRS. Read More

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June 2018
3 Reads

Combination therapy with clomiphene citrate and anastrozole is a safe and effective alternative for hypoandrogenic subfertile men.

BJU Int 2018 Jun 6. Epub 2018 Jun 6.

Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT, USA.

Objectives: To assess the efficacy and safety of combination therapy with clomiphene citrate (CC) and anastrozole (AZ) for male hypoandrogenism.

Patients And Methods: We identified patients treated with a combination of CC + AZ in the period 2014 to 2017. Data were gathered on patient characteristics and laboratory values at baseline. Read More

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Enhanced taxane uptake into bladder tissues following co-administration with either Mitomycin C, Doxorubicin or Gemcitabine: association to exfoliation processes.

BJU Int 2018 Jun 3. Epub 2018 Jun 3.

Associate Vice President Research & International, The University of British Columbia.

Objective: To investigate the effect of three anticancer drugs (mitomycin c (MMC), doxorubicin or gemcitabine) on bladder wall morphology and the uptake of paclitaxel or docetaxel following co-administration. We have recently shown that the levels of taxane drug uptake into bladder tissues may be significantly increased when the drug is administered in an amine terminated nanoparticulate formulation of the drug due to carrier-initiated exfoliation and increased drug diffusion into the tissue. The primary objective of this study was to measure the uptake of MMC, doxorubicin or gemcitabine with or without exposure of the tissue to amine terminated cationic nanoparticles (CNPs) and to investigate any possible exfoliation effects of the three drugs on intact bladder tissue. Read More

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June 2018
1 Read

Symptom Relief and Anejaculation after Aquablation or TURP: Subgroup Analysis from a Blinded Randomized Trial.

BJU Int 2018 Jun 4. Epub 2018 Jun 4.

UT Southwestern Medical Center, Department of Urology, University of Texas Southwestern, Dallas, TX, US.

Background: Aquablation, a waterjet-based prostate resection, has been used for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia. The hypothesis that BPH surgery standardized with robotic execution may have a more pronounced benefit in certain subgroups such as subjects with more challenging anatomies (e.g. Read More

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A Systematic Review and Meta-Analysis of the impact of Lymphovascular Invasion in Bladder Cancer Transurethral Resection Specimens.

BJU Int 2018 May 28. Epub 2018 May 28.

Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

Objectives: To assess the prognostic impact of lymphovascular invasion (LVI) in transurethral resection (TUR) of bladder cancer specimens on clinical outcomes.

Materials And Methods: A systematic review and meta-analysis of the available literature in the past 10 years was performed using the MEDLINE, EMBASE and Cochrane libraries in August 2017. The protocol for this systematic review was registered on PROSPERO (Central Registration Depository: CRD42018084876) and is available in full on the University of York website. Read More

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May 2018
2 Reads

The diagnostic accuracy of multiparametric MRI prior to biopsy in the detection of prostate cancer.

BJU Int 2018 May 27. Epub 2018 May 27.

Royal Devon and Exeter NHS Foundation Trust, Barrack Road, Exeter, EX2 5DW, UK.

Objectives: To determine the extent to which clinically significant prostate cancer (csPCa) can be detected in a routine NHS setting, in men with no previous biopsy, when mpMRI is introduced into the diagnostic pathway. This was assessed by comparing mpMRI PI-RADS scores to trans-perineal or trans-rectal ultrasound (TRUS) guided-biopsy findings as the reference standard. csPCa was defined as Gleason score of ≥ 3+4. Read More

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Bladder cancer in nonagenarians:a multicenter study of 123 patients.

BJU Int 2018 May 27. Epub 2018 May 27.

Department of Urology, Kaiser-Franz-Josef-Spital, Vienna, Austria.

Introduction: To investigate the oncological outcome of nonagenarians with bladder cancer as a substantial rise of bladder cancer in the old-old age group in the upcoming decades is expected, due to demographic changes and the peak incidence around the age of 85yrs. The paucity of data of nonagenarians prompted us to investigate the outcome of such patients.

Patients And Methods: A retrospective, multicenter study was designed to assess patient demographics, tumor patterns, treatment strategies and outcome in patients equal or older than 90 years treated at participating centers. Read More

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Renal function changes after percutaneous nephrolithotomy in patients with renal calculi with a solitary kidney compared to bilateral kidneys.

BJU Int 2018 May 26. Epub 2018 May 26.

Department of Urology, Shanghai Changhai Hospital, Shanghai, China.

Objective: To evaluate renal function changes and risk factors for acute kidney injury (AKI) after percutaneous nephrolithotomy (PCNL) in patients with renal calculi with a solitary kidney (SK) or normal bilateral kidneys (BKs).

Patients And Methods: Between 2012 and 2016, 859 patients undergoing PCNL were retrospectively reviewed at Changhai Hospital. In all, 53 patients with a SK were paired with 53 patients with normal BKs via a propensity score-matched analysis. Read More

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May 2018
4 Reads

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations.

BJU Int 2018 May 26. Epub 2018 May 26.

Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Objectives: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes.

Particpants And Methods: Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. Read More

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Does mirabegron relieve ureteral stent-related discomfort?: A prospective, randomized, multicenter study.

BJU Int 2018 May 26. Epub 2018 May 26.

Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.

Objectives: To evaluate the effects of 50 mg once daily mirabegron for ureteral stent-related discomfort after ureteroscopic procedures through a multicenter randomized study.

Patients And Methods: One hundred patients with indwelling ureteral stents following ureteroscopic stone removal or retrograde intrarenal surgery (RIRS) were randomized 1:1 to receive either no treatment or mirabegron during the stenting period. At the time of stent removal, the validated Ureteral Stent System Questionnaire (USSQ), International Prostate Symptom Score (IPSS), total amount of analgesics administered, and post voiding residual urine volume were reported for each patient. Read More

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May 2018
1 Read

The Impact of Bowel Management in Alleviating Symptoms of Urinary Incontinence in Spina Bifida Patients with Overactive Bladder and Detrusor Sphincter Dyssynergia.

BJU Int 2018 May 26. Epub 2018 May 26.

University Children's Hospital Belgrade.

Objective: To examine the effects of bowel management on urinary incontinence in spina bifida patients with overactive bladder and detrusor sphincter dyssynergia.

Materials And Method: The research was carried out over the 2014-2017 period. The first group consisted of 35 patients who were administered bowel management combined with anticholinergic medication therapy and clean intermittent catheterization (CIC). Read More

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Matrix metalloproteinase 7, soluble Fas and Fas ligand serum levels for predicting docetaxel resistance and survival in castration-resistant prostate cancer.

BJU Int 2018 May 26. Epub 2018 May 26.

Department of Urology, Vienna General Hospital, Medical University Vienna, Vienna, Austria.

Objective: To assess the predictive value of pre-chemotherapy matrix metalloproteinase 7 (MMP-7), soluble Fas (sFas) and Fas ligand (FasL) serum levels, as well as their changes during therapy.

Patients And Methods: Serum levels of MMP-7, Fas and FasL were determined by ELISA in 96 patients with castration-resistant prostate cancer (CRPC): 21 docetaxel-resistant patients who received one single series and 75 docetaxel-sensitive patients who received repeated series of docetaxel. In addition to the 96 pretreatment serum samples, 987 sera collected during chemotherapy were also analysed. Read More

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May 2018
1 Read

Effects of pathological upstaging or upgrading on metastasis and cancer-specific mortality in men with clinical low-risk prostate cancer.

BJU Int 2018 May 26. Epub 2018 May 26.

Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Objectives: To determine if the presence of adverse pathological features in patients eligible for active surveillance (AS) are prognostic of poor oncological outcomes, independent of pretreatment risk.

Patients And Methods: A retrospective analysis was performed on patients who underwent radical prostatectomy (RP) at two institutions (Cleveland Clinic Foundation and Memorial Sloan Kettering Cancer Center) between 1987 and 2008, and who had subsequent follow-up. Rates of biochemical recurrence, metastasis and death from prostate cancer were compared amongst patients with adverse pathological features (Gleason score ≥7, ≥pT3, or lymph node invasion) based on D'Amico clinical risk (low vs intermediate/high). Read More

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Practice Patterns of Female Urologists in Australia and New Zealand.

BJU Int 2018 May 24. Epub 2018 May 24.

St. Vincent's Health, Melbourne, Australia.

Objective: With more women joining the urology workforce, accurate and contemporary data are required. The objective of this study is to analyse practice patterns of female urologists in Australia and New Zealand.

Subjects And Methods: An electronic survey was sent to female urologists and urology trainees of the Urological Society of Australia and New Zealand in December 2016 with questions on demographics, practice patterns and views on mentorship. Read More

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Contemporary trends in the utilisation of radical prostatectomy.

BJU Int 2018 May 24. Epub 2018 May 24.

Division of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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May 2018
1 Read

Predictors of treatment success after collagenase Clostridium histolyticum injection for Peyronie's disease: development of a nomogram from a multicentre single-arm, non-placebo controlled clinical study.

BJU Int 2018 May 23. Epub 2018 May 23.

Department of Urology, Santa Maria Annunciata Hospital, Florence, Italy.

Objective: To build a nomogram able to predict treatment success after collagenase Clostridium histolyticum (CCH) for Peyronie's disease (PD).

Materials And Methods: Between November 2016 and November 2017, we enrolled 135 patients with PD into a multicentre single-arm prospective study. All patients enrolled received CCH treatment. Read More

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The association of bicycle-related genital numbness and Sexual Health Inventory for Men (SHIM) score: results from a large, multinational, cross-sectional study.

BJU Int 2018 May 23. Epub 2018 May 23.

Department of Urology, University of California San Francisco, San Francisco, CA, USA.

Objective: To assess the association of genital numbness and erectile dysfunction in male cyclists.

Subjects And Methods: Cyclists were recruited through Facebook advertisements and outreach to sporting clubs. This is a secondary analysis of a larger epidemiological population-based study that examined sexual and urinary wellness in athletes. Read More

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Crowdfunding for prostate cancer and breast cancer.

BJU Int 2018 May 22. Epub 2018 May 22.

Department of Urology and Population Health, New York University, New York, NY, USA.

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The serotonin (5-hydroxytryptamine) 5-HT receptor is up-regulated in Onuf's nucleus in rats with chronic spinal cord injury.

BJU Int 2018 May 21. Epub 2018 May 21.

Wake Forest Baptist Medical Center, Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA.

Objectives: To examine the effect of intrathecal (i.t.) serotonin (5-hydroxytryptamine) 5-HT agonist administration on voiding function in the urethane-anesthetised rat, and the change in 5-HT receptor (5-HT R) expression in the lumbosacral cord Onuf's nucleus after spinal cord injury (SCI). Read More

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May 2018
2 Reads

Guideline of guidelines: bladder pain syndrome.

BJU Int 2018 May 19. Epub 2018 May 19.

Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Objectives: Bladder pain syndrome (BPS) is a debilitating condition which can be difficult to diagnose and treat due to the lack of consensus on aetiology, definition, and management. The aim of this review is to summarise the findings from major national and international guidelines on the management of BPS, highlighting areas of disagreement and uncertainty.

Methods: We performed a Medline/PubMed search from 1st January 2000 to 31st December 2017 in order to identify relevant guidelines addressing BPS/interstitial cystitis. Read More

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May 2018
1 Read

Simulation in Urology to Train Non-Technical Skills in Ward Rounds.

BJU Int 2018 May 19. Epub 2018 May 19.

St. James' University Hospital, Leeds.

Objective: We have designed an exercise to train newly appointed Urology trainees in non-technical skills on ward rounds as a part of a simulation 'boot camp'. This paper reports our experience, including a qualitative analysis of participant feedback on the utility of this method of training.

Patients And Methods: The simulations took place in a high-fidelity simulated ward bay. Read More

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Importance of non-regional lymph nodes in assigning risk in primary metastatic prostate cancer.

BJU Int 2018 May 19. Epub 2018 May 19.

Genito-Urinary Cancer Research Group, Division of Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Manchester, UK.

Objective: To determine the prognostic relevance of non-regional lymph node (NRLN) metastases presenting synchronously with bone metastases in metastatic prostate cancer (mPCa) for guiding treatment decisions based on oligometastatic definitions.

Patients And Methods: Patients diagnosed with mPCa between 2004 and 2013 were identified from the Surveillance, Epidemiology and End Results database and were grouped by metastatic sites into only NRLN, only bone, bone + NRLN and other sites ± bone/NRLN metastases. Multivariate Cox and competing risk regression analyses were performed to compare the risks of all-cause mortality (ACM) and prostate cancer-specific mortality (PCSM) associated with bone + NRLN metastases before and after propensity-score matching to patients with only bone metastases. Read More

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Effect of Highly Concentrated Hyaluronic Acid/Chondroitin Sulfate Instillation on Ureteral Stent-induced Discomfort After Ureteroscopic Lithotripsy: A Multicenter Randomized Controlled Pilot Study.

BJU Int 2018 May 17. Epub 2018 May 17.

Department of Urology, Hanyang University Guri Hospital, Guri, Korea.

Objective: To investigate the efficacy and safety of instilling highly concentrated hyaluronic acid (HA)/chondroitin sulfate (CS) on the ureteral stent-related pain, urinary symptoms, and quality of life (QoL) of patients who underwent ureteroscopic lithotripsy for ureter stones followed by ureteral stent placement.

Patients And Methods: Eligible patients were randomly allocated to receive intravesical instillation with HA/CS or normal saline just after ureteral stent placement. Just before stent removal on postoperative day 7, the patients completed the Urinary Stent Symptom Questionnaire (USSQ), International Prostate Symptom Score (IPSS) QoL question, and pain Visual Analogue Scale (VAS). Read More

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Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short-course randomized study.

BJU Int 2018 May 17. Epub 2018 May 17.

King's College Hospital, London, UK.

Objectives: To compare serum testosterone response and symptom improvement in men with hypogonadism in response to treatment with clomiphene citrate (CC), human chorionic gonadotropin (hCG), or a combination of both therapies.

Patients And Methods: A total of 282 men with hypogonadism, wishing to preserve their fertility, were randomized to one of three treatment arms: CC 50 mg (n = 95); 5 000 IU hCG injections twice weekly (n = 94); or a combination of both therapies (CC + hCG; n = 94). All participants had complete medical history and had undergone thorough physical examination, including body mass index (BMI) assessment. Read More

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How can we expand active surveillance criteria in patients with low- and intermediate-risk prostate cancer without increasing the risk of misclassification? Development of a novel risk calculator.

BJU Int 2018 May 17. Epub 2018 May 17.

Department of Urology, Henri Mondor Hospital, Assistance-Publique Hopitaux de Paris, Creteil, France.

Objective: To develop a novel tool to increase the number of patients with prostate cancer eligible for active surveillance (AS) without increasing the risk of unfavourable pathological features (i.e., misclassification) at radical prostatectomy (RP). Read More

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May 2018
5 Reads

Novel nomograms for castration-resistant prostate cancer and survival outcome in patients with de novo bone metastatic prostate cancer.

BJU Int 2018 May 17. Epub 2018 May 17.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Objectives: To develop nomograms predicting the incidence of castration-resistant prostate cancer (CRPC) and overall survival (OS) for de novo metastatic prostate cancer (PCa).

Patients And Methods: Data from 449 patients with de novo metastatic PCa were retrospectively analysed. Patients were randomly divided into a training (n = 314, 70%) and a validation cohort (n = 135, 30%). Read More

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May 2018
1 Read

Computer-aided diagnosis of prostate cancer on magnetic resonance imaging using a convolutional neural network algorithm.

BJU Int 2018 May 17. Epub 2018 May 17.

Department of Urology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.

Objective: To develop a computer-aided diagnosis (CAD) algorithm with a deep learning architecture for detecting prostate cancer on magnetic resonance imaging (MRI) to promote global standardisation and diminish variation in the interpretation of prostate MRI.

Patients And Methods: We retrospectively reviewed data from 335 patients with a prostate-specific antigen level of <20 ng/mL who underwent MRI and extended systematic prostate biopsy with or without MRI-targeted biopsy. The data were divided into a training data set (n = 301), which was used to develop the CAD algorithm, and two evaluation data sets (n = 34). Read More

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May 2018
2 Reads

Radical prostatectomy in T4 prostate cancer after inductive androgen deprivation: results of a single-institution series with long-term follow-up.

BJU Int 2018 May 17. Epub 2018 May 17.

Department of Urology and Pediatric Urology, Saarland University, Homburg/Saar, Germany.

Objectives: To determine the outcomes of complete surgical resection of T4 prostate cancer after inductive androgen-deprivation therapy (ADT), as inductive ADT and subsequent radical prostatectomy (RP) is not recommended by any guideline yet.

Patients And Methods: A monocentric RP database was queried for patients initially diagnosed with T4 prostate cancer, considered primarily as inoperable because of a fixed mass defined by rectal examination in combination with high PSA level and/or large foci of biopsy confirmed undifferentiated prostate cancer. Treatment consisted of primary ADT until PSA nadir with consecutive RP. Read More

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