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    Tension-free vaginal tape for treatment of pure urodynamic stress urinary incontinence: efficacy and adverse effects at 17-year follow-up.
    BJU Int 2018 Feb 22. Epub 2018 Feb 22.
    Department of Obstetrics and Gynecology, University of Insubria, Varese, Italy.
    Objective: To assess the efficacy and safety of retropubic tension-free vaginal tape (TVT) 17 years after implantation for the treatment of female pure stress urinary incontinence (SUI).

    Patients And Methods: A prospective study was conducted in two urogynaecological units in two countries. All consecutive women with urodynamically proven pure SUI treated by TVT were included. Read More

    Testicular asymmetry in healthy adolescent boys.
    BJU Int 2018 Feb 20. Epub 2018 Feb 20.
    University of Antwerp, Faculty of medicine and health sciences, Antwerp, Belgium.
    Objectives: To assess the presence of testicular asymmetry and its currently used cut-off values in varicocele management in a healthy adolescent population.

    Patients And Methods: We conducted an observational cross-sectional study from April 2015 until December 2016 in which we recruited 539 adolescent boys aged 11 to 16 years. A clinical examination including testicular size measurement by ultrasonography was performed. Read More

    Computer Vision Detects Subtle Histological Effects of Dutasteride on Benign Prostate.
    BJU Int 2018 Feb 20. Epub 2018 Feb 20.
    Department of Pathology, College of Medicine, University of Illinois at Chicago.
    Objective: To determine whether a computer vision-based approach applied to H&E prostate biopsy images can distinguish dutasteride-treated tissue from placebo, and identify features associated with degree of responsiveness to 5α-reductase inhibitor (5ARI) therapy.

    Subjects And Methods: Our study population comprised 100 treatment-compliant men without prostate cancer assigned to dutasteride or placebo in the REDUCE trial who had slides available from mandatory Year 4 biopsies. Half the subjects also provided slides from a Year 2 biopsy. Read More

    Time trends and occupational variation in the incidence of testicular cancer in the Nordic countries.
    BJU Int 2018 Feb 20. Epub 2018 Feb 20.
    University Hospital of Turku, Department of Urology, Turku, Finland.
    Objective: To describe the trends and occupational variation in the incidence of testicular cancer in the Nordic countries utilising national cancer registries, NORDCAN (NORDCAN project/database presents the incidence, mortality, prevalence and survival from 50 major cancers in the Nordic countries) and NOCCA (Nordic Occupational Cancer) databases PATIENTS AND METHODS: We obtained the incidence data of testicular cancer for five-year periods from 1960-1964 to 2000-2014 and for five-year age-groups from NORDCAN database. Morphologic data on incident cases of seminoma and non-seminoma were obtained from national cancer registries. Age-standardised incidence rates (ASR) were calculated per 100 000 person-years (World Standard). Read More

    Peri-Prostatic Adipose Tissue: The metabolic microenvironment of prostate cancer.
    BJU Int 2018 Feb 20. Epub 2018 Feb 20.
    University of Adelaide Medical School, Adelaide, SA, 5005, Australia.
    Emerging data has linked certain features of clinical prostate cancer (PCa) to obesity and, more specifically, increased adiposity. Whereas the large number of clinical studies and meta-analyses that have explored the associations between PCa and obesity have shown considerable variability, particularly in relation to prostate cancer risk, there is an accumulating weight of evidence consistently linking obesity to greater aggressiveness of disease. In probing this association mechanistically, it has been posited that the peri-prostatic adipose tissue (PPAT), a significant component of the prostate microenvironment, may be a critical source of fatty acids and other mitogens and thereby influences PCa pathogenesis and progression. Read More

    Perioperative outcome and complications following laparoscopic versus robotic-assisted dismembered pyeloplasty: a systematic review and meta-analysis.
    BJU Int 2018 Feb 17. Epub 2018 Feb 17.
    Department of Urology, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT.
    Objective: To analyse the current difference between dismembered robotic-assisted pyeloplasty (RP) and laparoscopic pyeloplasty (LP) in the treatment of pelvi-ureteric junction obstruction (PUJO) patients as of June 26 2017, focusing on operative time, length of hospital stay, complication rate, and success rate.

    Patients And Methods: We searched PubMed, Medline, and Embase databases, consulted experts, reviewed reference lists, used the related articles PubMed feature, and reviewed scientific meeting abstracts for eligible articles from 1993 to June 26 2017. A modified Newcastle-Ottawa scale was used to assess study quality. Read More

    Shortcomings in the management of undescended testis: guideline intention vs. reality and the underlying causes - insights from the biggest German cohort.
    BJU Int 2018 Feb 16. Epub 2018 Feb 16.
    Centre for Clinical and Translational Research (CCTR), Centre of Paediatrics and Adolescent Medicine, HELIOS University Hospital Wuppertal, Faculty of Health, Witten/Herdecke University.
    Objectives: To assess the implementation of the current guideline and identify potential underlying causes for late surgery in children with Undescended testis (UDT) in Germany. UDT is the most common surgical issue in paediatric urology. To avoid malignant degeneration and subfertility current guidelines recommend orchidopexy during the first year of life. Read More

    Surgeon-Led Prostate Cancer Lymph Node Staging: Pathologic Outcomes Stratified by Robot-Assisted Dissection Templates and Patient Selection.
    BJU Int 2018 Feb 15. Epub 2018 Feb 15.
    Departments of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Objectives: To evaluate the peri-operative, pathologic, and oncologic outcomes from surgeon led pathologic staging of pelvic lymph node metastases at the time of robot-assisted radical prostatectomy (RARP).

    Patients And Methods: Over the 6-year period of 2006-2012, three distinct pelvic lymph node dissection strategies were utilized in chronologic order at a single cancer referral hospital. Strategies were characterized by both a 1) omission of PLND versus inclusion decision threshold, and 2) standard versus extended templates for patients selected for PLND. Read More

    Are all gonadotropin-releasing hormone agonists equivalent for the treatment of prostate cancer? A systematic review.
    BJU Int 2018 Feb 13. Epub 2018 Feb 13.
    Department of Urology, St James's Hospital, Dublin 8, Ireland.
    Objectives: To review comparative studies of the gonadotropin-releasing hormone (GnRH) agonists goserelin, triptorelin, and leuprorelin for the treatment of prostate cancer, and identify whether there are meaningful clinical differences between these agents.

    Methods: In June 2017, the following searches were performed independently by two reviewers in PubMed: (i) 'prostate cancer' and 'triptorelin' and 'leuprorelin', (ii) 'prostate cancer' and 'triptorelin' and 'goserelin', and (iii) 'prostate cancer' and 'goserelin' and 'leuprorelin', without time restriction. Duplicates were deleted. Read More

    BAUS Consensus Document for the Management of Male Genital Emergencies - Penile Fracture.
    BJU Int 2018 Feb 13. Epub 2018 Feb 13.
    University College London Hospital.
    Male genital emergencies relating to the penis and scrotum are rare and require prompt investigation and surgical intervention. Clinicians are often unfamiliar with the management of these conditions and may not work in a specialist centre with on-site expertise in genitourethral surgery available. The aim of these consensus statements is to provide a best practice guidance for urological surgeons based in the UK and developed by an expert consensus. Read More

    Managing penetrating renal trauma: Experience from two UK major trauma centres.
    BJU Int 2018 Feb 13. Epub 2018 Feb 13.
    Department of Urology, St George's Hospital, London, UK.
    Objectives: To present our series of patients with penetrating renal trauma from two urban major trauma centres and discuss contemporary management of these injuries.

    Methods: We reviewed prospective urological trauma databases for all patients presenting with penetrating renal trauma between January 2005 and October 2016. Patient demographics, clinical characteristics, imaging, management and follow-up data were analysed. Read More

    Progression and treatment rates using an active surveillance protocol incorporating image guided baseline biopsies and multi-parametric MRI monitoring for men with favourable risk prostate cancer.
    BJU Int 2018 Feb 13. Epub 2018 Feb 13.
    Academic Urology Group, University of Cambridge, UK.
    Objective: To assess early outcomes since the introduction of an active surveillance (AS) protocol incorporating mpMRI guided baseline biopsies and image based surveillance.

    Patients And Methods: A new AS protocol mandating image-guided baseline biopsies, annual mpMRI and 3 monthly PSA but which retained protocol re-biopsies was tested. Pathological progression, treatment conversion and triggers for non-protocol biopsy were recorded prospectively. Read More

    Incidence and immediate management of genitourinary injuries in pelvic and acetabular trauma: A 10-year retrospective study.
    BJU Int 2018 Feb 8. Epub 2018 Feb 8.
    Department of Trauma and Orthopaedics, Tallaght hospital, Dublin, Ireland.
    Objective: To report the incidence of genito-urinary (GU) injuries in pelvic and acetabular (P + A) fractures and to investigate associations between P + A fractures and GU injury patterns. We also prospectively evaluated P + A fracture referrals for adherence to the British Orthopaedic Association Standards for Trauma (BOAST) guidelines over a 12-month period.

    Methods: A retrospective review of genitourinary injuries associated with P + A fractures was performed from January 2006 to December 2016 in a national pelvic trauma centre in Ireland. Read More

    Contemporary Surgical Management of Renal Oncocytoma: A nation's outcome.
    BJU Int 2018 Feb 3. Epub 2018 Feb 3.
    Consultant urological surgeon, Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.
    Objectives: To report on the contemporary UK experience of surgical management of renal oncocytomas.

    Subjects And Methods: Descriptive analysis of practice and postoperative outcomes of cases with a final histological diagnosis of oncocytoma included in The British Association of Urological Surgeons (BAUS) nephrectomy registry from 01/01/2013 to 31/12/2016. Short term outcomes were assessed over a follow-up of 30 days. Read More

    A multicentre integration of a computer led follow up in surgical oncology is valid and safe.
    BJU Int 2018 Feb 2. Epub 2018 Feb 2.
    University of Nottingham, The Medical School, Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3DT.
    Background: Prostate cancer (CaP) has a rising number of patients requiring routine follow up. In this study, we aimed to test a computer led follow up service for prostate cancer in two UK hospitals. The testing aimed to validate the computer Expert system in making clinical decisions according to the individual patient's clinical need. Read More

    Cost-Effectiveness of Magnetic Resonance Imaging and Targeted Fusion Biopsy for Early Detection of Prostate Cancer.
    BJU Int 2018 Feb 1. Epub 2018 Feb 1.
    Department of Industrial and Operations Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
    Objective: To determine how best to use MRI and targeted MR/ultrasound fusion biopsy for early detection of prostate cancer in men with elevated PSA and whether it can be cost-effective.

    Methods: A Markov model of prostate cancer onset and progression was developed to estimate health and economic consequences of prostate cancer screening with MRI. Men were screened with prostate-specific antigen (PSA) from ages 55 to 69. Read More

    Variability and Interpretation of Communication Taxonomy during Robot-assisted Surgery: Do We All Speak the Same Language?
    BJU Int 2018 Feb 1. Epub 2018 Feb 1.
    Department of Urology, Roswell Park Cancer Institute, Buffalo, NY.
    Introduction: To investigate and analyze the different ways surgeons communicate with bedside assistants during robot-assisted surgery (RAS).

    Methods: We retrospectively reviewed video and audio recordings of 26 RAS (23 prostatectomies and 3 cystectomies). Three cameras and 8 lapel microphones were utilized to record the OR environment. Read More

    Ileal vaginoplasty as vaginal reconstruction in transgender women and patients with disorders of sex development: An international, multicenter, retrospective study on surgical characteristics and outcomes.
    BJU Int 2018 Feb 1. Epub 2018 Feb 1.
    Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, Netherlands.
    Objectives: To describe surgical outcomes of ileal vaginoplasty in transgender women and patients with disorders of sex development (DSD).

    Patients And Methods: Transgender women and DSD patients, who underwent ileal vaginoplasty at the VU University Medical Center Amsterdam, University Hospital Trieste, University Hospital Essen and Belgrade University Hospital, were retrospectively identified. A chart review was performed, recording surgical technique, intraoperative characteristics, complications and reoperations. Read More

    Transdermal Oestradiol as a method of androgen suppression for Prostate Cancer within the STAMPEDE Trial Platform.
    BJU Int 2018 Feb 1. Epub 2018 Feb 1.
    MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, 90 High Holborn, London, WC1V 6LJ.
    Androgen deprivation therapy (ADT) remains a cornerstone of the management of prostate cancer. The addition of ADT to radiotherapy improves disease-free and overall survival in the locally advanced setting and ADT forms the backbone onto which additional treatments may be added (either initially at first presentation or sequentially at disease progression). ADT is most commonly achieved with Gonadotrophin Releasing Hormone analogues (GnRHa) that act through the hypothalamic-pituitary-gonadal axis to prevent testicular production of testosterone. Read More

    Taxane chemotherapy versus anti-androgen agents as first-line therapy for metastatic castration-resistant prostate cancer.
    BJU Int 2018 Feb 1. Epub 2018 Feb 1.
    Sanofi, Bridgewater, NJ, USA.
    Objectives: To assess treatment patterns and outcomes of patients with metastatic castration-resistant prostate cancer (mCRPC) receiving first-line chemotherapy or anti-androgen therapy.

    Patients And Methods: Patients initiating first-line anti-androgen therapy (abiraterone, enzalutamide) or chemotherapy (taxane) from Oct/2012-Sept/2014 were retrospectively identified in the US Veterans Health Administration (VHA) database. The impact of anti-androgen therapy versus chemotherapy on overall survival (OS) and time to discontinuation was assessed using Cox proportional hazard models, adjusting for prior androgen deprivation therapy (ADT) duration and available prognostic factors. Read More

    The BAUS radical prostatectomy audit 2014/2015 - an update on current practice and outcomes by centre and surgeon case volume.
    BJU Int 2018 Feb 1. Epub 2018 Feb 1.
    British Association of Urological Surgeons.
    Objectives: To describe contemporary radical prostatectomy (RP) practice using the British Association of Urological Surgeons (BAUS) data and audit project and to observe differences in practice in relation to surgeon or centre case volume.

    Patients And Methods: Data on 13,920 Radical Prostatectomy (RP) procedures performed by 178 surgeons across 86 centres were recorded on the BAUS data and audit platform between 1st January 2014 and 31st December 2015. This equates to approximately 95% of total RPs performed over this period when compared to HES (Hospital Episode Statistics) data. Read More

    Impact of testosterone replacement therapy on thromboembolism, heart disease, and obstructive sleep apnea in men.
    BJU Int 2018 Jan 30. Epub 2018 Jan 30.
    Center for Surgery and Public Health, Brigham and Women's Hospital Harvard Medical School, Boston, Massachusetts, USA.
    Objectives: To assess the association of TRT with thromboembolism, cardiovascular disease (stroke, coronary artery disease, and heart failure) and obstructive sleep apnea (OSA).

    Methods: A cohort of 3,422 male United States military service members, retirees and their dependents, aged 40-64 was identified, who were prescribed TRT between 2006-2010 for low testosterone. Men in this cohort were matched on a 1:1 basis by age and comorbidities to men without a prescription for TRT. Read More

    Radiotherapy-related complications presenting to a urology department - a more common problem than previously thought?
    BJU Int 2018 Jan 23. Epub 2018 Jan 23.
    Department of Urology, Austin Health, Heidelberg, Victoria, Australia.
    Objective: Complications are an undesired side effect of any treatment and radiotherapy is no different. The aim of this study was to quantify the burden of these side effects in a tertiary referral urology department.

    Patients And Methods: A prospective study of all urology admissions in a six-month period to a public urology department at a tertiary hospital was performed. Read More

    Performance comparison of two androgen receptor splice variant 7 (AR-V7) detection methods.
    BJU Int 2018 Jan 23. Epub 2018 Jan 23.
    Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
    Objectives: To compare the performance of two established androgen receptor splice variant 7 (AR-V7) mRNA detection systems, as paradoxical responses to next-generation androgen-deprivation therapy in AR-V7 mRNA-positive circulating tumour cells (CTC) of patients with castration-resistant prostate cancer (CRPC) could be related to false-positive classification using detection systems with different sensitivities.

    Materials And Methods: We compared the performance of two established mRNA-based AR-V7 detection technologies using either SYBR Green or TaqMan chemistries. We assessed in vitro performance using eight genitourinary cancer cell lines and serial dilutions in three AR-V7-positive prostate cancer cell lines, as well as in 32 blood samples from patients with CRPC. Read More

    Management of paediatric high-grade blunt renal trauma: a 10-year single-centre UK experience.
    BJU Int 2018 Jan 23. Epub 2018 Jan 23.
    Department of Paediatric Surgery, Alder Hey Children's Hospital, Liverpool, UK.
    Objective: To report the management and outcome of paediatric patients sustaining high-grade blunt renal trauma.

    Patients And Methods: Medical records were examined for all American Association for the Surgery of Trauma (AAST) grade III-V blunt renal trauma cases admitted to a paediatric trauma centre from 2005 to 2015. Data collected and analysed included: demographics, imaging modalities, management, length of hospital stay (LOS), complications, and follow-up outcomes. Read More

    A clinician-centred programme for behaviour change in the optimal use of staging investigations for newly diagnosed prostate cancer.
    BJU Int 2018 Jan 23. Epub 2018 Jan 23.
    School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
    Objectives: To improve imaging utilisation and reduce the widespread overuse of staging investigations, in the form of computed tomography (CT) and whole-body bone scans for men with newly diagnosed prostate cancer in the Hunter region of NSW, Australia, by implementation of a multifaceted clinician-centred behaviour change programme.

    Patients And Methods: Records of all patients with a new diagnosis of prostate cancer were reviewed prior to the intervention (July 2014 to July 2015), and the results of this audit were presented to participating urologists by a clinical champion. Urologists then underwent focused education based on current guidelines. Read More

    Open radical cystectomy in England: the current standard of care - an analysis of the British Association of Urological Surgeons (BAUS) cystectomy audit and Hospital Episodes Statistics (HES) data.
    BJU Int 2018 Jan 23. Epub 2018 Jan 23.
    Bristol Urological Institute, Southmead Hospital, Bristol, UK.
    Objective: To establish the current standard for open radical cystectomy (ORC) in England, as data entry by surgeons performing RC to the British Association of Urological Surgeons (BAUS) database was mandated in 2013 and combining this with Hospital Episodes Statistics (HES) data has allowed comprehensive outcome analysis for the first time.

    Patients And Methods: All patients were included in this analysis if they were uploaded to the BAUS data registry and reported to have been performed in the 2 years between 1 January 2014 and 31 December 2015 in England (from mandate onwards) and had been documented as being performed in an open fashion (not laparoscopic, robot assisted or the technique field left blank). The HES data were accessed via the HES website. Read More

    3-Year follow-up of temporary implantable nitinol device implantation for the treatment of benign prostatic obstruction.
    BJU Int 2018 Jan 23. Epub 2018 Jan 23.
    Division of Urology, Department of Oncology - School of Medicine, San Luigi Hospital, University of Turin, Orbassano (Turin), Italy.
    Objectives: To report 3-year follow-up results of the first implantations with a temporary implantable nitinol device (TIND; Medi-Tate Ltd., Or Akiva, Israel) for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).

    Patients And Methods: In all, 32 patients with LUTS were enrolled in this prospective study. Read More

    External validation of the prostascore model in patients with metastatic hormone-sensitive prostate cancer recruited to the CHAARTED study.
    BJU Int 2018 Jan 23. Epub 2018 Jan 23.
    Department of Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
    Objective: To externally validate 'prostascore' in patients with metastatic hormone-sensitive prostate cancer recruited to the phase III CHAARTED study.

    Methods: We conducted a retrospective analysis of the prospectively collected data from patients with metastatic hormone-sensitive prostate cancer in the CHAARTED study, a phase III multicentre study conducted between 2006 and 2014. The main outcome of the present analysis was overall survival, assessed using Kaplan-Meier analysis or log-rank testing, in the whole cohort according to different prostascores. Read More

    Robotic Partial Nephrectomy for Large Renal Masses: A Multi-institutional Series.
    BJU Int 2018 Jan 22. Epub 2018 Jan 22.
    Mount Sinai Medical Center, Miami, FL.
    Objectives: To compare perioperative outcomes after RPN for cT2a (7 to <10cm) to cT1 tumors. Robotic partial nephrectomy (RPN) for T1 tumors has been shown to be safe, however, evaluation of PN for larger, complex tumors is lacking.

    Materials And Methods: Patients with a cT1a (n=1358, 76. Read More

    BAUS Consensus Document for the Management of Male Genital Emergencies - Priapism.
    BJU Int 2018 Jan 22. Epub 2018 Jan 22.
    Department of Urology, Leicester General Hospital, Leicester, Leicestershire, United Kingdom of Great Britain and Northern Ireland.
    Male genital emergencies relating to the penis and scrotum are rare and require prompt investigation and surgical intervention. Clinicians are often unfamiliar with the management of these conditions and may not work in a specialist centre with on-site expertise in genitourethral surgery available. A series of consensus statements have been developed by an expert consensus comprising BAUS Section of Andrology and Genitourethral Surgery together with experts from units throughout the UK. Read More

    Microdenervation of the spermatic cord for post-vasectomy pain syndrome.
    BJU Int 2018 Jan 20. Epub 2018 Jan 20.
    Division of Urology, Rush University Medical Center, Chicago, IL, USA.
    Objective: To evaluate the outcomes of patients who underwent microdenervation of the spermatic cord (MDSC) for post-vasectomy pain syndrome (PVPS) at our institution.

    Methods: A retrospective study of all patients who underwent MDSC for PVPS by a single surgeon between March 2002 and October 2016 was performed. Pain was documented using the numerical rating scale (NRS). Read More

    BAUS Consensus Document for the Management of Male Genital Emergencies - Penile Amputation.
    BJU Int 2018 Jan 13. Epub 2018 Jan 13.
    University College London Hospital, London, United Kingdom of Great Britain and Northern Ireland.
    Male genital emergencies relating to the penis and scrotum are rare and require prompt investigation and surgical intervention. Clinicians are often unfamiliar with the management of these conditions and may not work in a specialist centre with on-site expertise in genitourethral surgery available. A series of consensus statements have been developed by an expert consensus comprising BAUS Section of Andrology and Genitourethral Surgery together with experts from units throughout the UK. Read More

    Outcomes of more than 1 000 percutaneous nephrolithotomies and validation of Guy's stone score.
    BJU Int 2018 Jan 11. Epub 2018 Jan 11.
    Division of Urology, Men's Health Centre, Hospital Brigadeiro, Sao Paulo, SP, Brazil.
    Objective: To present the experience with percutaneous nephrolithotomy (PCNL) at a high-volume Brazilian centre and to evaluate Guy's stone score (GSS) as a predictor of success and complications in PCNL.

    Patients And Methods: We prospectively evaluated patients who underwent PCNL between June 2011 and October 2016. Indications for PCNL included renal stones >2 cm in size and stones <2 cm in size in which first-line techniques had failed. Read More

    Low-dose-rate brachytherapy for prostate cancer: outcomes at >10 years of follow-up.
    BJU Int 2018 Jan 10. Epub 2018 Jan 10.
    Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Objective: To examine biochemical control, survival, and late morbidity with definitive low-dose-rate brachytherapy (LDR-BT) for patients with prostate cancer surviving for >10 years after treatment.

    Patients And Methods: We identified 757 men with localised prostate cancer who underwent definitive LDR-BT in the period 1990-2006 and were followed for >10 years at our institution. Biochemical failure-free survival (BFFS), distant metastases-free survival (DMFS), prostate cancer-specific survival (PCSS), and overall survival (OS) were selected as study endpoints. Read More

    Which outcome measures should be used in stress urinary incontinence trials?
    BJU Int 2018 Jan 10. Epub 2018 Jan 10.
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
    Objective: To review measures used in recent randomised controlled trials (RCTs) evaluating stress urinary incontinence (SUI) treatments and to propose the most relevant outcome measure that should be included in future trials.

    Materials And Methods: We identified RCTs for SUI interventions published between January 2015 and July 2017. We listed the objective and subjective outcome measures used in eligible trials in the literature search. Read More

    The Role of Lymph Node Dissection in the Management of Renal Cell Carcinoma: A Systematic Review and Meta-Analysis.
    BJU Int 2018 Jan 10. Epub 2018 Jan 10.
    Division of Urology, Rhode Island Hospital, The Miriam Hospital, Providence, RI.
    Objectives: To evaluate the role of retroperitoneal lymph node dissection (LND) in non-metastatic (M0) and metastatic (M1) renal cell carcinoma (RCC).

    Patients And Methods: We searched Medline, EMBASE, Web of Science, and Scopus from database inception to August 29, 2017 for studies of patients who underwent partial or radical nephrectomy for M0 or M1 RCC. Two investigators independently selected studies for inclusion. Read More

    The effect of timing of an immediate instillation of mitomycin C after transurethral resection in 941 patients with non-muscle-invasive bladder cancer.
    BJU Int 2018 Jan 10. Epub 2018 Jan 10.
    Department of Urology, VU university Medical Center, Amsterdam, The Netherlands.
    Objective: To investigate whether the timing of an immediate instillation of mitomycin C (on the day of transurethral resection of bladder tumour [TURBT] or 1 day later) has an impact on time to recurrence of non-muscle-invasive bladder cancer (NMIBC).

    Patients And Methods: All patients with NMIBC who were enrolled in a prospective trial between 1998 and 2003, and treated with an early mitomycin C instillation (on the day of TURBT or 1 day later), were selected. Statistical analysis was performed with Kaplan-Meier curves and multivariable Cox regression. Read More

    Outcomes and toxicities in patients with intermediate-risk prostate cancer treated with brachytherapy alone or brachytherapy and supplemental external beam radiation therapy.
    BJU Int 2018 Jan 10. Epub 2018 Jan 10.
    Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Objective: To evaluate the cancer control outcomes and long-term treatment-related morbidity of brachytherapy as well as combination brachytherapy and external beam radiation therapy (EBRT) in patients with intermediate-risk prostate cancer.

    Materials And Methods: A retrospective review was conducted in a prospectively collected database of patients with intermediate-risk prostate cancer who were treated either with brachytherapy or brachytherapy and EBRT, with or without androgen deprivation therapy (ADT), in the period 1990-2014. Urinary and erectile dysfunction symptoms were measured using the International Prostate Symptom Score (IPSS), the Mount Sinai erectile function scale and the Sexual Health Inventory for Men (SHIM). Read More

    Nerve-sparing radical cystectomy has a beneficial impact on urinary continence after orthotopic bladder substitution, which becomes even more apparent over time.
    BJU Int 2018 Jan 10. Epub 2018 Jan 10.
    Department of Urology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    Objective: To analyse urinary continence in long-term survivors after radical cystectomy (RC) and orthotopic bladder substitution (OBS) according to attempted nerve-sparing (NS) status.

    Patients And Methods: We analysed 180 consecutive patients treated at our department between 1985 and 2007, who underwent RC with OBS, and survived ≥10 years after RC. We stratified patients by attempted NS status and evaluated continence outcomes using descriptive statistics and Cox proportional hazards regression models. Read More

    Aquablation therapy for symptomatic benign prostatic hyperplasia: a single-centre experience in 47 patients.
    BJU Int 2018 Jan 10. Epub 2018 Jan 10.
    Department of Urology, Muljibhai Patel Urological Hospital, Nadiad, India.
    Objective: To report procedure process improvements and confirm the preserved safety and short-term effectiveness of a second-generation Aquablation device for the treatment of lower urinary tract symptoms (LUTS) attributable to benign prostatic hyperplasia (BPH) in 47 consecutive patients at a single institution.

    Patients And Methods: Aquablation was performed in 47 patients with symptomatic BPH at a single institution. Baseline, peri-operative and 3-month urinary function data were collected. Read More

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